WFDC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)8.35200699
2regulation of transforming growth factor beta1 production (GO:0032908)8.16210956
3keratinocyte differentiation (GO:0030216)8.05982510
4linoleic acid metabolic process (GO:0043651)7.59019487
5keratinocyte proliferation (GO:0043616)7.53276244
6positive regulation of glomerulus development (GO:0090193)7.31309910
7fatty acid elongation (GO:0030497)6.83484510
8peptide cross-linking (GO:0018149)6.81664086
9regulation of cell proliferation involved in kidney development (GO:1901722)6.77893545
10epidermal cell differentiation (GO:0009913)6.45547151
11lipoxygenase pathway (GO:0019372)6.18209981
12sphingoid metabolic process (GO:0046519)6.15476532
13hair cycle (GO:0042633)6.07781169
14molting cycle (GO:0042303)6.07781169
15gap junction assembly (GO:0016264)5.73486676
16regulation of natural killer cell differentiation (GO:0032823)5.39182323
17chemical homeostasis within a tissue (GO:0048875)5.38440896
18sphingosine metabolic process (GO:0006670)5.31126990
19regulation of ruffle assembly (GO:1900027)5.24164558
20skin morphogenesis (GO:0043589)5.23267588
21bundle of His cell to Purkinje myocyte communication (GO:0086069)5.22351122
22epidermis development (GO:0008544)5.16536660
23positive regulation of interleukin-8 secretion (GO:2000484)4.89616928
24surfactant homeostasis (GO:0043129)4.85099681
25regulation of glomerulus development (GO:0090192)4.71847061
26diol metabolic process (GO:0034311)4.70866920
27phospholipid scrambling (GO:0017121)4.63572215
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.61964786
29polarized epithelial cell differentiation (GO:0030859)4.58582634
30G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.55403300
31glucosamine-containing compound catabolic process (GO:1901072)4.45062944
32lateral sprouting from an epithelium (GO:0060601)4.41446483
33hemidesmosome assembly (GO:0031581)4.28816775
34phospholipid efflux (GO:0033700)4.21015103
35ectoderm development (GO:0007398)4.18510502
36intermediate filament organization (GO:0045109)4.12085983
37cyclooxygenase pathway (GO:0019371)4.11687934
38detection of bacterium (GO:0016045)4.07256089
39phosphatidylinositol acyl-chain remodeling (GO:0036149)3.99252244
40positive regulation of transforming growth factor beta production (GO:0071636)3.99200359
41transepithelial transport (GO:0070633)3.95306707
42phosphatidylserine metabolic process (GO:0006658)3.93199884
43fatty-acyl-CoA metabolic process (GO:0035337)3.88663636
44epithelial cell differentiation involved in prostate gland development (GO:0060742)3.85594423
45epithelium development (GO:0060429)3.76436562
46positive regulation of cholesterol efflux (GO:0010875)3.67619802
47positive regulation of monocyte chemotaxis (GO:0090026)3.59084539
48detection of external biotic stimulus (GO:0098581)3.58222014
49phospholipid catabolic process (GO:0009395)3.57788711
50detection of other organism (GO:0098543)3.56473773
51regulation of interleukin-8 secretion (GO:2000482)3.55188218
52long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.55169045
53prostanoid biosynthetic process (GO:0046457)3.46323086
54prostaglandin biosynthetic process (GO:0001516)3.46323086
55unsaturated fatty acid biosynthetic process (GO:0006636)3.45865756
56regulation of keratinocyte differentiation (GO:0045616)3.41817511
57sphingolipid biosynthetic process (GO:0030148)3.35691121
58positive regulation of cholesterol transport (GO:0032376)3.32416980
59positive regulation of sterol transport (GO:0032373)3.32416980
60ceramide biosynthetic process (GO:0046513)3.31924085
61phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.30767542
62regulation of T cell chemotaxis (GO:0010819)3.30513378
63positive regulation of T cell chemotaxis (GO:0010820)3.30513378
64phosphatidylserine acyl-chain remodeling (GO:0036150)3.30015610
65hair follicle morphogenesis (GO:0031069)3.24800187
66negative regulation of interleukin-17 production (GO:0032700)3.21502531
67alditol phosphate metabolic process (GO:0052646)3.20527973
68fatty-acyl-CoA biosynthetic process (GO:0046949)3.20500768
69phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.19562990
70retinal metabolic process (GO:0042574)3.19429715
71glutathione biosynthetic process (GO:0006750)3.12737853
72regulation of hypersensitivity (GO:0002883)3.12138143
73regulation of phospholipase A2 activity (GO:0032429)3.10458285
74sequestering of metal ion (GO:0051238)3.09286290
75regulation of keratinocyte proliferation (GO:0010837)3.09094295
76detection of biotic stimulus (GO:0009595)3.05859994
77intestinal epithelial cell development (GO:0060576)3.01572189
78cardiolipin metabolic process (GO:0032048)3.00253668
79phosphatidylcholine acyl-chain remodeling (GO:0036151)2.99966823
80positive regulation of collagen biosynthetic process (GO:0032967)2.98419330
81very long-chain fatty acid metabolic process (GO:0000038)2.92649302
82one-carbon compound transport (GO:0019755)2.91729308
83copper ion transport (GO:0006825)2.87317130
84positive regulation of collagen metabolic process (GO:0010714)2.87200098
85nonribosomal peptide biosynthetic process (GO:0019184)2.87052297
86positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.84679882
87regulation of neuron projection regeneration (GO:0070570)2.83232887
88regulation of axon regeneration (GO:0048679)2.83232887
89arachidonic acid metabolic process (GO:0019369)2.82021094
90regulation of transforming growth factor beta production (GO:0071634)2.82005776
91keratinocyte development (GO:0003334)2.81656955
92eyelid development in camera-type eye (GO:0061029)2.79845350
93viral transcription (GO:0019083)2.78369364
94polyol transport (GO:0015791)2.77051373
95prostaglandin metabolic process (GO:0006693)2.76756108
96prostanoid metabolic process (GO:0006692)2.76756108
97intermediate filament cytoskeleton organization (GO:0045104)2.75417400
98regulation of protein localization to cell surface (GO:2000008)2.75342276
99negative regulation of stress fiber assembly (GO:0051497)2.73784380
100ventricular cardiac muscle cell action potential (GO:0086005)2.70191748
101intermediate filament-based process (GO:0045103)2.69349113
102positive regulation of epidermis development (GO:0045684)2.67421106
103fatty acid derivative metabolic process (GO:1901568)2.67360667
104icosanoid metabolic process (GO:0006690)2.67360667
105establishment of planar polarity (GO:0001736)2.66868236
106establishment of tissue polarity (GO:0007164)2.66868236
107regulation of epidermis development (GO:0045682)2.66453619
108regulation of natural killer cell activation (GO:0032814)2.65752554
109phosphatidylglycerol metabolic process (GO:0046471)2.63869546
110negative regulation of acute inflammatory response (GO:0002674)2.62990673
111regulation of collagen biosynthetic process (GO:0032965)2.61639139
112arachidonic acid secretion (GO:0050482)2.60599936
113icosanoid secretion (GO:0032309)2.60599936
114hair cycle process (GO:0022405)2.59278927
115molting cycle process (GO:0022404)2.59278927
116G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.58946824
117negative regulation of keratinocyte proliferation (GO:0010839)2.58532362
118planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58189744
119genitalia morphogenesis (GO:0035112)2.57953532
120negative regulation of interferon-gamma production (GO:0032689)2.57429308
121regulation of monocyte chemotaxis (GO:0090025)2.57342239
122translational termination (GO:0006415)2.55598596
123regulation of cholesterol efflux (GO:0010874)2.53297096
124positive regulation of epidermal cell differentiation (GO:0045606)2.51896112
125negative regulation of cell fate specification (GO:0009996)2.47821284
126regulation of epidermal cell differentiation (GO:0045604)2.46650583
127epithelial cell differentiation (GO:0030855)2.44573121
128negative regulation of epidermal cell differentiation (GO:0045605)2.42575301
129defense response to fungus (GO:0050832)2.41208763
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40504620
131regulation of heart rate by cardiac conduction (GO:0086091)2.39368354
132skin development (GO:0043588)2.33933909
133atrioventricular valve morphogenesis (GO:0003181)2.33158088
134negative regulation of epidermis development (GO:0045683)2.31723030
135regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.31535306
136epithelial cell proliferation (GO:0050673)2.31189502
137regulation of cholesterol homeostasis (GO:2000188)2.28700955
138cell communication involved in cardiac conduction (GO:0086065)2.17912056
139mitotic G1 DNA damage checkpoint (GO:0031571)2.14675647
140cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.12696140
141imidazole-containing compound metabolic process (GO:0052803)2.11491221
142cell-cell junction assembly (GO:0007043)2.09363000
143cardiac muscle cell action potential involved in contraction (GO:0086002)2.08549660
144establishment of skin barrier (GO:0061436)17.2673196
145regulation of water loss via skin (GO:0033561)15.1013311
146keratinization (GO:0031424)14.9177291
147desmosome organization (GO:0002934)12.4948745
148long-chain fatty acid biosynthetic process (GO:0042759)10.5720362
149multicellular organismal water homeostasis (GO:0050891)10.0276818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.69082556
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.39406019
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.84979269
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.68317668
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.64653740
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.48042165
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.45893574
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39344919
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.25518677
10TP63_17297297_ChIP-ChIP_HaCaT_Human12.6561299
11FOXO3_23340844_ChIP-Seq_DLD1_Human1.93752340
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76814695
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76814695
14TCF4_18268006_ChIP-ChIP_LS174T_Human1.76100962
15ZNF263_19887448_ChIP-Seq_K562_Human1.64839104
16SOX2_20726797_ChIP-Seq_SW620_Human1.63264959
17TP63_23658742_ChIP-Seq_EP156T_Human1.61294947
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59307722
19GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.59042762
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51490231
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50036239
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49752127
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46433810
24EGR1_19032775_ChIP-ChIP_M12_Human1.44528395
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42188741
26GATA6_21074721_ChIP-Seq_CACO-2_Human1.40806121
27TP53_18474530_ChIP-ChIP_U2OS_Human1.35979149
28* TP63_22573176_ChIP-Seq_HFKS_Human1.34159065
29GATA3_24758297_ChIP-Seq_MCF-7_Human1.34086573
30CJUN_26792858_Chip-Seq_BT549_Human1.33439247
31KLF5_25053715_ChIP-Seq_YYC3_Human1.28552592
32CEBPB_22108803_ChIP-Seq_LS180_Human1.25457555
33GATA4_25053715_ChIP-Seq_YYC3_Human1.24426899
34RXR_22108803_ChIP-Seq_LS180_Human1.24264338
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.23981569
36ERG_20517297_ChIP-Seq_VCAP_Human1.23581947
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23087518
38CTCF_27219007_Chip-Seq_Bcells_Human1.17541245
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16806078
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15007231
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12912600
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.12832845
43RACK7_27058665_Chip-Seq_MCF-7_Human1.11133965
44BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10811324
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09846845
46ATF3_27146783_Chip-Seq_COLON_Human1.09515125
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08091060
48CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05957064
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.05080752
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03761464
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01721947
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99985721
53RBPJ_21746931_ChIP-Seq_IB4_Human0.99938351
54EZH2_27294783_Chip-Seq_ESCs_Mouse0.98976893
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98074379
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98036072
57UBF1/2_26484160_Chip-Seq_HMECs_Human0.97934101
58SA1_27219007_Chip-Seq_ERYTHROID_Human0.97630410
59BCAT_22108803_ChIP-Seq_LS180_Human0.97493302
60DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97151777
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96874786
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96390857
63PIAS1_25552417_ChIP-Seq_VCAP_Human0.95711586
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95481394
65PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95339256
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95189058
67P53_21459846_ChIP-Seq_SAOS-2_Human0.92805546
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91168807
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90510136
70TCF4_22108803_ChIP-Seq_LS180_Human0.89058062
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88216987
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88216987
73HNFA_21074721_ChIP-Seq_CACO-2_Human0.88055179
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87320108
75ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85140736
76VDR_22108803_ChIP-Seq_LS180_Human0.84767524
77EZH2_27304074_Chip-Seq_ESCs_Mouse0.84088028
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82861866
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82287742
80TP53_20018659_ChIP-ChIP_R1E_Mouse0.82212499
81P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81977378
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81304263
83CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80774883
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80516773
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79960129
86EED_16625203_ChIP-ChIP_MESCs_Mouse0.79818464
87GATA3_21867929_ChIP-Seq_TH1_Mouse0.79419641
88AR_21572438_ChIP-Seq_LNCaP_Human0.79363174
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79070297
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78995920
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78868777
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78820494
93CTCF_20526341_ChIP-Seq_ESCs_Human0.78693667
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77743391
95SMAD4_21799915_ChIP-Seq_A2780_Human0.77689559
96JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77609575
97SA1_27219007_Chip-Seq_Bcells_Human0.77327822
98PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77278856
99CDX2_22108803_ChIP-Seq_LS180_Human0.76380164
100* LXR_22292898_ChIP-Seq_THP-1_Human0.75602785
101AR_25329375_ChIP-Seq_VCAP_Human0.74244007
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74036829
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73663976
104CBX2_22325352_ChIP-Seq_293T-Rex_Human0.73156013
105SMC4_20622854_ChIP-Seq_HELA_Human0.73018026
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72918594
107AHR_22903824_ChIP-Seq_MCF-7_Human0.72853169
108NANOG_20526341_ChIP-Seq_ESCs_Human0.72469956
109E2F1_20622854_ChIP-Seq_HELA_Human0.72419261
110BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72380872
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72024412
112KDM2B_26808549_Chip-Seq_K562_Human0.71840022
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71208354
114BCOR_27268052_Chip-Seq_Bcells_Human0.71157002
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.70902825
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.70671459
117NCOR_22424771_ChIP-Seq_293T_Human0.70652363
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.70634875
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.70467041
120* GATA6_25053715_ChIP-Seq_YYC3_Human0.69713660
121P68_20966046_ChIP-Seq_HELA_Human0.69097330
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69068377
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68763243
124OCT1_27270436_Chip-Seq_PROSTATE_Human0.68688633
125PHF8_20622853_ChIP-Seq_HELA_Human0.68037834
126* TAF2_19829295_ChIP-Seq_ESCs_Human0.67698157
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67189833
128HTT_18923047_ChIP-ChIP_STHdh_Human0.66974094
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.65202585
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.64926848
131GATA1_22025678_ChIP-Seq_K562_Human0.64082802
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.63961492
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.63961492
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63937737
135TP53_16413492_ChIP-PET_HCT116_Human0.63779622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.26636402
2MP0010234_abnormal_vibrissa_follicle6.52402129
3MP0003941_abnormal_skin_development6.08278388
4MP0005275_abnormal_skin_tensile6.04221142
5MP0005501_abnormal_skin_physiology5.69089669
6MP0005451_abnormal_body_composition5.41117696
7MP0004381_abnormal_hair_follicle3.71610175
8MP0001216_abnormal_epidermal_layer3.32816540
9MP0002060_abnormal_skin_morphology3.27792617
10MP0010771_integument_phenotype3.24167719
11MP0004947_skin_inflammation2.96403005
12MP0000579_abnormal_nail_morphology2.61166446
13MP0010678_abnormal_skin_adnexa2.60075601
14MP0003191_abnormal_cellular_cholesterol2.55619788
15MP0003453_abnormal_keratinocyte_physiol2.54846570
16MP0000647_abnormal_sebaceous_gland2.46161774
17MP0002098_abnormal_vibrissa_morphology2.37990532
18MP0003878_abnormal_ear_physiology2.34806162
19MP0005377_hearing/vestibular/ear_phenot2.34806162
20MP0004885_abnormal_endolymph2.28649187
21MP0000377_abnormal_hair_follicle2.07453754
22MP0002254_reproductive_system_inflammat1.98866216
23MP0000383_abnormal_hair_follicle1.93716691
24MP0000467_abnormal_esophagus_morphology1.93019831
25MP0000427_abnormal_hair_cycle1.82761443
26MP0009931_abnormal_skin_appearance1.79534125
27MP0001191_abnormal_skin_condition1.74250521
28MP0004185_abnormal_adipocyte_glucose1.70445746
29MP0004782_abnormal_surfactant_physiolog1.55227354
30MP0003705_abnormal_hypodermis_morpholog1.52929175
31MP0000566_synostosis1.36804888
32MP0000762_abnormal_tongue_morphology1.26025095
33MP0001243_abnormal_dermal_layer1.23592943
34MP0003566_abnormal_cell_adhesion1.22249646
35MP0000367_abnormal_coat/_hair1.21938800
36MP0000015_abnormal_ear_pigmentation1.02054318
37MP0005174_abnormal_tail_pigmentation0.96407932
38MP0001346_abnormal_lacrimal_gland0.95688317
39MP0003136_yellow_coat_color0.94960933
40MP0001851_eye_inflammation0.92385603
41MP0003011_delayed_dark_adaptation0.85207474
42MP0000465_gastrointestinal_hemorrhage0.85144859
43MP0008004_abnormal_stomach_pH0.84111369
44MP0003950_abnormal_plasma_membrane0.83099774
45MP0002009_preneoplasia0.81086976
46MP0002234_abnormal_pharynx_morphology0.80819869
47MP0001340_abnormal_eyelid_morphology0.72815026
48MP0009379_abnormal_foot_pigmentation0.71351871
49MP0001784_abnormal_fluid_regulation0.66542970
50MP0006054_spinal_hemorrhage0.65205080
51MP0004019_abnormal_vitamin_homeostasis0.61571829
52MP0001984_abnormal_olfaction0.56521322
53MP0005666_abnormal_adipose_tissue0.56394508
54MP0002877_abnormal_melanocyte_morpholog0.50318400
55MP0010352_gastrointestinal_tract_polyps0.48958884
56MP0009780_abnormal_chondrocyte_physiolo0.46306707
57MP0003763_abnormal_thymus_physiology0.45759945
58MP0001177_atelectasis0.45168337
59MP0002138_abnormal_hepatobiliary_system0.44723348
60MP0010386_abnormal_urinary_bladder0.44302369
61MP0002177_abnormal_outer_ear0.43579020
62MP0002249_abnormal_larynx_morphology0.43372948
63MP0008961_abnormal_basal_metabolism0.43294908
64MP0008789_abnormal_olfactory_epithelium0.42928782
65MP0003329_amyloid_beta_deposits0.42249842
66MP0002090_abnormal_vision0.41668950
67MP0005499_abnormal_olfactory_system0.41433090
68MP0005394_taste/olfaction_phenotype0.41433090
69MP0005076_abnormal_cell_differentiation0.41174455
70MP0005187_abnormal_penis_morphology0.40953566
71MP0000516_abnormal_urinary_system0.40173255
72MP0005367_renal/urinary_system_phenotyp0.40173255
73MP0005375_adipose_tissue_phenotype0.39237319
74MP0005023_abnormal_wound_healing0.36687939
75MP0000428_abnormal_craniofacial_morphol0.35909626
76MP0005075_abnormal_melanosome_morpholog0.34929299
77MP0000685_abnormal_immune_system0.34725753
78MP0003315_abnormal_perineum_morphology0.33809331
79MP0002095_abnormal_skin_pigmentation0.32251016
80MP0009672_abnormal_birth_weight0.32082281
81MP0000569_abnormal_digit_pigmentation0.31060194
82MP0000627_abnormal_mammary_gland0.30068975
83MP0001853_heart_inflammation0.28075056
84MP0001485_abnormal_pinna_reflex0.27880301
85MP0000013_abnormal_adipose_tissue0.27217934
86MP0004264_abnormal_extraembryonic_tissu0.26384622
87MP0001299_abnormal_eye_distance/0.25967498
88MP0005503_abnormal_tendon_morphology0.25512271
89MP0009053_abnormal_anal_canal0.24976684
90MP0003638_abnormal_response/metabolism_0.24222944
91MP0002233_abnormal_nose_morphology0.22353120
92MP0001542_abnormal_bone_strength0.20902349
93MP0001666_abnormal_nutrient_absorption0.20842954
94MP0002166_altered_tumor_susceptibility0.20741761
95MP0009333_abnormal_splenocyte_physiolog0.20637985
96MP0010030_abnormal_orbit_morphology0.20601785
97MP0009384_cardiac_valve_regurgitation0.20469787
98MP0002971_abnormal_brown_adipose0.19811916
99MP0005409_darkened_coat_color0.19809822
100MP0001186_pigmentation_phenotype0.19391258
101MP0005508_abnormal_skeleton_morphology0.18929542
102MP0002006_tumorigenesis0.18725289
103MP0003252_abnormal_bile_duct0.18523040
104MP0003195_calcinosis0.17815621
105MP0000372_irregular_coat_pigmentation0.17156909
106MP0000470_abnormal_stomach_morphology0.16720136
107MP0001849_ear_inflammation0.16237955
108MP0002111_abnormal_tail_morphology0.16127486
109MP0004043_abnormal_pH_regulation0.15162139
110MP0001765_abnormal_ion_homeostasis0.15084156
111MP0002697_abnormal_eye_size0.14867535
112MP0005193_abnormal_anterior_eye0.14707649
113MP0003755_abnormal_palate_morphology0.14313274
114MP0000462_abnormal_digestive_system0.14206178
115MP0000747_muscle_weakness0.14154007
116MP0008569_lethality_at_weaning0.13800429
117MP0003279_aneurysm0.13722069
118MP0004197_abnormal_fetal_growth/weight/0.13635541
119MP0005257_abnormal_intraocular_pressure0.13491439
120MP0001188_hyperpigmentation0.12556224
121MP0003436_decreased_susceptibility_to0.11746665
122MP0002118_abnormal_lipid_homeostasis0.11612118
123MP0005165_increased_susceptibility_to0.11600208
124MP0000432_abnormal_head_morphology0.11593994
125MP0002133_abnormal_respiratory_system0.11549814
126MP0005388_respiratory_system_phenotype0.11549814
127MP0003828_pulmonary_edema0.11132723
128MP0002282_abnormal_trachea_morphology0.11064675
129MP0003300_gastrointestinal_ulcer0.09856408
130MP0006138_congestive_heart_failure0.09183592

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.03855260
2Abnormality of nail color (HP:0100643)7.44251419
3Hypotrichosis (HP:0001006)6.76413136
4Erythroderma (HP:0001019)6.14393654
5Ectropion (HP:0000656)6.12592583
6Gangrene (HP:0100758)6.11169631
7Parakeratosis (HP:0001036)5.73387766
8Right ventricular cardiomyopathy (HP:0011663)5.56639683
9Corneal erosion (HP:0200020)5.34310484
10Erythema (HP:0010783)5.30615930
11Palmoplantar hyperkeratosis (HP:0000972)5.17743762
12Woolly hair (HP:0002224)5.11437878
13Plantar hyperkeratosis (HP:0007556)4.89017602
14Onycholysis (HP:0001806)4.86476207
15Palmar hyperkeratosis (HP:0010765)4.85269265
16Lip pit (HP:0100267)4.80329657
17Hypohidrosis (HP:0000966)4.52394907
18Hyporeflexia of lower limbs (HP:0002600)4.39142979
19Pruritus (HP:0000989)4.16009397
20Conjunctival hamartoma (HP:0100780)4.06532224
21Absent eyelashes (HP:0000561)3.88493903
22Palmoplantar keratoderma (HP:0000982)3.82626281
23Lack of skin elasticity (HP:0100679)3.76279381
24Curly hair (HP:0002212)3.62628691
25Fragile nails (HP:0001808)3.41444395
26Absent hair (HP:0002298)3.36697418
27Distal lower limb muscle weakness (HP:0009053)3.25080386
28Areflexia of lower limbs (HP:0002522)3.20942547
29Abnormal blistering of the skin (HP:0008066)3.19950555
30Paralysis (HP:0003470)3.15763062
31Thick nail (HP:0001805)3.12229579
32Dehydration (HP:0001944)3.09166504
33Acanthosis nigricans (HP:0000956)2.97349859
34Ventricular tachycardia (HP:0004756)2.92387810
35Pili torti (HP:0003777)2.90930211
36Sparse scalp hair (HP:0002209)2.90192543
37Concave nail (HP:0001598)2.83180888
38Hypergammaglobulinemia (HP:0010702)2.81337281
39Natal tooth (HP:0000695)2.79187365
40Nail dystrophy (HP:0008404)2.75154081
41Selective tooth agenesis (HP:0001592)2.73322724
42Dry skin (HP:0000958)2.73158469
43Brittle hair (HP:0002299)2.72606794
44Sparse eyelashes (HP:0000653)2.66863888
45Popliteal pterygium (HP:0009756)2.66412484
46Malignant hyperthermia (HP:0002047)2.61257620
47Slow-growing hair (HP:0002217)2.58405477
48Abnormality of hair growth rate (HP:0011363)2.58405477
49Furrowed tongue (HP:0000221)2.51927125
50Advanced eruption of teeth (HP:0006288)2.50479510
51Abnormality of the salivary glands (HP:0010286)2.49800779
52Abnormality of placental membranes (HP:0011409)2.48502355
53Amniotic constriction ring (HP:0009775)2.48502355
54Milia (HP:0001056)2.45562548
55Blepharitis (HP:0000498)2.44059399
56Sepsis (HP:0100806)2.37355914
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34044730
58Hamartoma of the eye (HP:0010568)2.31128796
59Abnormality of the axillary hair (HP:0100134)2.25888752
60Abnormality of secondary sexual hair (HP:0009888)2.25888752
61Split foot (HP:0001839)2.24800880
62Abnormality of permanent molar morphology (HP:0011071)2.20908744
63Abnormality of the dental root (HP:0006486)2.20908744
64Taurodontia (HP:0000679)2.20908744
65Follicular hyperkeratosis (HP:0007502)2.20433938
66Aplasia involving bones of the extremities (HP:0009825)2.20131323
67Aplasia involving bones of the upper limbs (HP:0009823)2.20131323
68Aplasia of the phalanges of the hand (HP:0009802)2.20131323
69Chronic bronchitis (HP:0004469)2.19557061
70Autoamputation (HP:0001218)2.16502111
71Nasolacrimal duct obstruction (HP:0000579)2.15237291
72Eczematoid dermatitis (HP:0000976)2.09336826
73Abnormality of molar morphology (HP:0011070)2.08743055
74Abnormality of molar (HP:0011077)2.08743055
75Oligodontia (HP:0000677)2.08635794
76Oral leukoplakia (HP:0002745)2.07318863
77Recurrent corneal erosions (HP:0000495)2.07202406
78Dry hair (HP:0011359)2.06695452
79Abnormal hair laboratory examination (HP:0003328)2.05293002
80Melanocytic nevus (HP:0000995)2.03992010
81Sensory axonal neuropathy (HP:0003390)2.03456966
82Hypoplastic labia majora (HP:0000059)2.03047781
83Xerostomia (HP:0000217)2.00651172
84Congenital nonbullous ichthyosiform erythroderma (HP:0007479)11.5308015
85Congenital ichthyosiform erythroderma (HP:0007431)11.2008570
86Pustule (HP:0200039)1.97578499
87Abnormality of the dental pulp (HP:0006479)1.97073759
88Duplicated collecting system (HP:0000081)1.95237165
89Septate vagina (HP:0001153)1.91553564
90Villous atrophy (HP:0011473)1.90648587
91Abnormality of small intestinal villus morphology (HP:0011472)1.90648587
92Premature ovarian failure (HP:0008209)1.87501810
93Laryngomalacia (HP:0001601)1.85582214
94Ventricular fibrillation (HP:0001663)1.84713112
95Severe Myopia (HP:0011003)1.83378839
96Abnormality of the labia majora (HP:0012881)1.82063552
97Everted lower lip vermilion (HP:0000232)1.80098506
98Congenital, generalized hypertrichosis (HP:0004540)1.80031043
99Exercise-induced myalgia (HP:0003738)1.79710352
100Depressed nasal tip (HP:0000437)1.79474186
101Hamartoma (HP:0010566)1.78668680
102Alopecia of scalp (HP:0002293)1.78093019
103Asthma (HP:0002099)1.74886918
104Multifactorial inheritance (HP:0001426)1.74833310
105Fine hair (HP:0002213)1.71917425
106Round ear (HP:0100830)1.71523489
107Abnormality of the lacrimal duct (HP:0011481)1.70898807
108Urticaria (HP:0001025)1.65822546
109Abnormality of the renal collecting system (HP:0004742)1.65619664
110Skin ulcer (HP:0200042)1.65117226
111Achilles tendon contracture (HP:0001771)1.63855570
112Anonychia (HP:0001798)1.62316560
113Abnormality of the gastric mucosa (HP:0004295)1.61019236
114Anhidrosis (HP:0000970)1.58760169
115Muscle fiber inclusion bodies (HP:0100299)1.58439493
116Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.58230819
117Difficulty running (HP:0009046)1.57532777
118Increased connective tissue (HP:0009025)1.57170588
119Myopathic facies (HP:0002058)1.57091107
120Breast hypoplasia (HP:0003187)1.55126232
121Hyperhidrosis (HP:0000975)1.54998707
122Carious teeth (HP:0000670)1.53904711
123Fasciculations (HP:0002380)1.53681542
124Distal arthrogryposis (HP:0005684)1.53649893
125Abnormality of the nasolacrimal system (HP:0000614)1.53577145
126Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.53550187
127Stenosis of the external auditory canal (HP:0000402)1.53355246
128Sudden death (HP:0001699)1.53310262
129Ulnar claw (HP:0001178)1.52958705
130Abnormality of the Achilles tendon (HP:0005109)1.51841965
131Labial hypoplasia (HP:0000066)1.50481693
132Distal lower limb amyotrophy (HP:0008944)1.50361134
133Corneal dystrophy (HP:0001131)1.49932507
134Ridged nail (HP:0001807)1.49713762
135Nemaline bodies (HP:0003798)1.48275516
136Pterygium (HP:0001059)1.46301037
137Type 1 muscle fiber predominance (HP:0003803)1.41711355
138Skin pits (HP:0100276)1.40760938
139Steppage gait (HP:0003376)1.40355286
140Conical tooth (HP:0000698)1.39873808
141Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.37047553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR16.78184301
2MAPKAPK35.46268338
3MST44.46572617
4MAP3K23.41628627
5MST1R3.19667802
6FER2.81901109
7MAP3K32.80219104
8EPHB22.38946955
9RPS6KB22.36184724
10PIK3CG2.33261678
11MAPK72.18574748
12TTN2.17947360
13ERN11.88863214
14TRPM71.80807534
15MAP3K91.78698163
16PIM21.76174608
17SGK2231.74147456
18SGK4941.74147456
19LATS11.72427537
20MAP3K111.65140061
21TESK11.65137281
22BLK1.65071190
23BCR1.57214774
24LRRK21.53569809
25MAPKAPK51.49060042
26STK101.46675876
27PTK61.40599323
28ERBB31.40307488
29FRK1.38404609
30MAP3K121.37747465
31FGFR11.35814302
32ITK1.35632114
33MAP3K71.26833734
34FGFR41.24130838
35MAP2K41.24031727
36NLK1.23572666
37IKBKB1.21642356
38TAOK11.20532132
39TYRO31.17222161
40ACVR1B1.16752250
41MAP2K61.16242211
42DYRK1B1.15557223
43LIMK11.13633049
44OBSCN1.12651671
45PRPF4B1.12590322
46NTRK21.12244211
47SYK1.06909657
48CDK191.05710759
49WNK11.04080374
50MAP3K141.01461243
51FGFR21.01330094
52MAP2K30.99562851
53GRK60.99306158
54RPS6KB10.99024178
55BMPR1B0.98459043
56SRPK10.97926041
57MET0.97857283
58RIPK10.96644132
59GRK50.96633595
60SGK20.96237001
61KIT0.95453100
62MAP3K10.91679943
63EPHA30.90875180
64NME20.90615619
65MAP3K60.86779872
66AKT30.86282830
67MARK20.85192634
68STK38L0.83755265
69TGFBR20.82005786
70IRAK10.80651079
71PRKCE0.79382711
72CDK30.79103041
73MAPKAPK20.78786670
74STK380.78395432
75DMPK0.78180847
76BRD40.76551487
77PAK30.75386756
78EPHA40.73576021
79EPHB10.72296614
80CDK120.71390891
81STK110.71335220
82PKN10.70568219
83LATS20.68777422
84GRK10.68716424
85GRK70.67686931
86PBK0.67131983
87PRKD10.66313430
88SGK30.65360646
89CDK60.64439795
90EIF2AK20.63023907
91ADRBK10.61974729
92MAP3K50.61967169
93BMPR20.61597982
94SIK10.61317719
95FLT30.60728274
96PRKAA20.59251923
97RIPK40.58522678
98EEF2K0.56749282
99TAOK30.54334811
100EPHA20.52066592
101FGFR30.50169492
102CSNK1D0.50020903
103STK240.49953526
104SGK10.49841231
105CASK0.48764768
106MAP2K10.47673949
107MTOR0.47099511
108PHKG20.45422668
109PHKG10.45422668
110FGR0.44891870
111MOS0.44621635
112MINK10.42008098
113GSK3A0.41466007
114PDGFRA0.40091238
115PRKCI0.39858716
116CAMK1G0.38693442
117RET0.38685677
118ROCK10.37073050
119MAPK40.36906018
120ABL10.36545151
121PRKD20.35106960
122IGF1R0.34122230
123ILK0.32961801
124TYK20.31861840
125JAK30.31366451
126ERBB40.31190456
127TRIB30.30036394
128MAPK120.29839457
129STK30.29603475
130ICK0.28464449
131SRC0.28450953
132CAMK1D0.28300213
133MAP2K20.27129563
134BRAF0.26952756
135RPS6KA10.26031463
136TTK0.25489615
137TNK20.24850838
138PTK20.24802464
139MAPK90.23982757
140JAK10.23886811
141PDGFRB0.23808925
142TAF10.23586186
143KSR20.21671060
144CHUK0.21577616
145MELK0.20189705
146IRAK20.19872683
147TXK0.19141293

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.16511352
2Sphingolipid metabolism_Homo sapiens_hsa006004.03030443
3Fatty acid elongation_Homo sapiens_hsa000623.98351970
4Arachidonic acid metabolism_Homo sapiens_hsa005903.49710668
5Linoleic acid metabolism_Homo sapiens_hsa005913.44900669
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.44673708
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.29234512
8Ether lipid metabolism_Homo sapiens_hsa005652.27531067
9Histidine metabolism_Homo sapiens_hsa003402.19636344
10ABC transporters_Homo sapiens_hsa020102.11801544
11Ribosome_Homo sapiens_hsa030102.04445618
12Retinol metabolism_Homo sapiens_hsa008301.67225222
13Fat digestion and absorption_Homo sapiens_hsa049751.57867072
14Phenylalanine metabolism_Homo sapiens_hsa003601.53081097
15Tight junction_Homo sapiens_hsa045301.50638131
16Collecting duct acid secretion_Homo sapiens_hsa049661.48555521
17Serotonergic synapse_Homo sapiens_hsa047261.42995700
18Amoebiasis_Homo sapiens_hsa051461.42749736
19Choline metabolism in cancer_Homo sapiens_hsa052311.38890118
20VEGF signaling pathway_Homo sapiens_hsa043701.38582565
21Fatty acid biosynthesis_Homo sapiens_hsa000611.31158980
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30527468
23Steroid biosynthesis_Homo sapiens_hsa001001.30055200
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22886135
25Sphingolipid signaling pathway_Homo sapiens_hsa040711.15182502
26Glycerolipid metabolism_Homo sapiens_hsa005611.14005976
27Phototransduction_Homo sapiens_hsa047441.08854161
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.08022069
29Staphylococcus aureus infection_Homo sapiens_hsa051501.07996536
30GnRH signaling pathway_Homo sapiens_hsa049121.07050802
31Axon guidance_Homo sapiens_hsa043601.06442126
32Renin secretion_Homo sapiens_hsa049241.01008241
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99063946
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96238915
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95419677
36Adherens junction_Homo sapiens_hsa045200.95288965
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86259869
38Chemical carcinogenesis_Homo sapiens_hsa052040.85657389
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85369751
40Phospholipase D signaling pathway_Homo sapiens_hsa040720.83063525
41Long-term depression_Homo sapiens_hsa047300.82077349
42Fatty acid metabolism_Homo sapiens_hsa012120.81281361
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81159369
44Salivary secretion_Homo sapiens_hsa049700.79994184
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.79788935
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78970014
47Olfactory transduction_Homo sapiens_hsa047400.78810987
48Glutathione metabolism_Homo sapiens_hsa004800.78026407
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76936922
50Pertussis_Homo sapiens_hsa051330.76378738
51Melanogenesis_Homo sapiens_hsa049160.76366260
52Mineral absorption_Homo sapiens_hsa049780.76251489
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.74636655
54MicroRNAs in cancer_Homo sapiens_hsa052060.71888729
55Ras signaling pathway_Homo sapiens_hsa040140.71171360
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70618782
57Tyrosine metabolism_Homo sapiens_hsa003500.70315785
58Acute myeloid leukemia_Homo sapiens_hsa052210.69970753
59Fatty acid degradation_Homo sapiens_hsa000710.64876367
60Gastric acid secretion_Homo sapiens_hsa049710.63882495
61beta-Alanine metabolism_Homo sapiens_hsa004100.63735654
62Vibrio cholerae infection_Homo sapiens_hsa051100.63013684
63Pancreatic secretion_Homo sapiens_hsa049720.59960920
64ErbB signaling pathway_Homo sapiens_hsa040120.59559141
65Basal cell carcinoma_Homo sapiens_hsa052170.59516134
66Hepatitis C_Homo sapiens_hsa051600.58661630
67PPAR signaling pathway_Homo sapiens_hsa033200.58540715
68Thyroid cancer_Homo sapiens_hsa052160.58147312
69Inositol phosphate metabolism_Homo sapiens_hsa005620.57427693
70Platelet activation_Homo sapiens_hsa046110.56202108
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54787262
72Oxytocin signaling pathway_Homo sapiens_hsa049210.53639721
73MAPK signaling pathway_Homo sapiens_hsa040100.53179009
74Hedgehog signaling pathway_Homo sapiens_hsa043400.51812112
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51315462
76Proteoglycans in cancer_Homo sapiens_hsa052050.50798050
77Long-term potentiation_Homo sapiens_hsa047200.50797180
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.50694396
79Ovarian steroidogenesis_Homo sapiens_hsa049130.49031182
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48124720
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47521731
82p53 signaling pathway_Homo sapiens_hsa041150.46531647
83Glutamatergic synapse_Homo sapiens_hsa047240.45991133
84ECM-receptor interaction_Homo sapiens_hsa045120.43393354
85Taste transduction_Homo sapiens_hsa047420.43387004
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42345599
87Arginine biosynthesis_Homo sapiens_hsa002200.42241329
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41803784
89Notch signaling pathway_Homo sapiens_hsa043300.40595038
90Oxidative phosphorylation_Homo sapiens_hsa001900.40261645
91Alzheimers disease_Homo sapiens_hsa050100.39991583
92Lysosome_Homo sapiens_hsa041420.39396837
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38886437
94Hippo signaling pathway_Homo sapiens_hsa043900.38227787
95Estrogen signaling pathway_Homo sapiens_hsa049150.37193831
96Calcium signaling pathway_Homo sapiens_hsa040200.35812688
97Endocytosis_Homo sapiens_hsa041440.35194399
98Other glycan degradation_Homo sapiens_hsa005110.34989595
99Bladder cancer_Homo sapiens_hsa052190.34833737
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34234329
101cAMP signaling pathway_Homo sapiens_hsa040240.33270937
102Glioma_Homo sapiens_hsa052140.33248604
103Renal cell carcinoma_Homo sapiens_hsa052110.32750363
104Protein digestion and absorption_Homo sapiens_hsa049740.32609272
105Circadian entrainment_Homo sapiens_hsa047130.32546916
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.32477389
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32275174
108Influenza A_Homo sapiens_hsa051640.32128176
109Rheumatoid arthritis_Homo sapiens_hsa053230.31328695
110Insulin signaling pathway_Homo sapiens_hsa049100.31068221
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30917263
112Circadian rhythm_Homo sapiens_hsa047100.30864197
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30660348
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30643352
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30029308
116Dorso-ventral axis formation_Homo sapiens_hsa043200.29795504
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29526525
118Pathways in cancer_Homo sapiens_hsa052000.28448973
119Toxoplasmosis_Homo sapiens_hsa051450.27592933
120Peroxisome_Homo sapiens_hsa041460.27269193
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.27068735
122Pancreatic cancer_Homo sapiens_hsa052120.26848604
123Rap1 signaling pathway_Homo sapiens_hsa040150.26837597
124Small cell lung cancer_Homo sapiens_hsa052220.26239290
125Phagosome_Homo sapiens_hsa041450.26134677
126Tuberculosis_Homo sapiens_hsa051520.25698162
127Glucagon signaling pathway_Homo sapiens_hsa049220.25266891
128TGF-beta signaling pathway_Homo sapiens_hsa043500.23027322
129Wnt signaling pathway_Homo sapiens_hsa043100.21752805
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21427336

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