WFDC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.41426703
2regulation of cilium movement (GO:0003352)8.56990254
3left/right axis specification (GO:0070986)7.40482871
4ventricular system development (GO:0021591)6.99856662
5vitamin transmembrane transport (GO:0035461)6.97621484
6primary alcohol catabolic process (GO:0034310)6.87949873
7microtubule bundle formation (GO:0001578)6.67128695
8intraciliary transport (GO:0042073)6.25760558
9ethanol metabolic process (GO:0006067)6.09814228
10cilium organization (GO:0044782)6.04057953
11cilium assembly (GO:0042384)5.84548691
12diterpenoid biosynthetic process (GO:0016102)5.42474684
13response to xenobiotic stimulus (GO:0009410)5.37734254
14centriole assembly (GO:0098534)5.23290022
15tolerance induction (GO:0002507)5.19013774
16one-carbon compound transport (GO:0019755)5.13275012
17pyrimidine-containing compound transmembrane transport (GO:0072531)5.12144794
18regulation of microtubule-based movement (GO:0060632)4.97545536
19lung epithelium development (GO:0060428)4.96446764
20sperm capacitation (GO:0048240)4.84569534
21regulation of interleukin-5 production (GO:0032674)4.82048922
22microtubule-based movement (GO:0007018)4.81991206
23protein localization to cilium (GO:0061512)4.79896823
24negative regulation of T cell differentiation in thymus (GO:0033085)4.65194546
25cellular component assembly involved in morphogenesis (GO:0010927)4.65006098
26establishment of apical/basal cell polarity (GO:0035089)4.63375504
27negative regulation of immunoglobulin mediated immune response (GO:0002890)4.60635581
28negative regulation of B cell mediated immunity (GO:0002713)4.60635581
29glomerular epithelial cell development (GO:0072310)4.43572334
30negative regulation of humoral immune response (GO:0002921)4.39464326
31regulation of interleukin-13 production (GO:0032656)4.32720787
32cell projection assembly (GO:0030031)4.28830578
33regulation of germinal center formation (GO:0002634)4.26585098
34ethanol oxidation (GO:0006069)4.22847906
35cilium morphogenesis (GO:0060271)4.19628838
36positive regulation of tolerance induction (GO:0002645)4.11967502
37establishment or maintenance of monopolar cell polarity (GO:0061339)3.99114582
38establishment of monopolar cell polarity (GO:0061162)3.99114582
39cytoplasmic microtubule organization (GO:0031122)3.98208638
40nucleoside diphosphate phosphorylation (GO:0006165)3.95716236
41negative regulation of inclusion body assembly (GO:0090084)3.92100378
42exogenous drug catabolic process (GO:0042738)3.84615073
43terpenoid biosynthetic process (GO:0016114)3.84153204
44lateral ventricle development (GO:0021670)3.77082857
45microtubule depolymerization (GO:0007019)3.69443979
46microtubule polymerization or depolymerization (GO:0031109)3.62576900
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.57566307
48retinoic acid metabolic process (GO:0042573)3.56433101
49establishment of tissue polarity (GO:0007164)3.29747438
50establishment of planar polarity (GO:0001736)3.29747438
51aldehyde catabolic process (GO:0046185)3.23593681
52primary alcohol metabolic process (GO:0034308)3.16298176
53positive regulation of smoothened signaling pathway (GO:0045880)3.14014403
54regulation of microtubule depolymerization (GO:0031114)3.13268644
55O-glycan processing (GO:0016266)3.11072508
56regulation of tolerance induction (GO:0002643)3.10136010
57multicellular organismal water homeostasis (GO:0050891)3.07217896
58determination of left/right symmetry (GO:0007368)3.01786779
59carnitine metabolic process (GO:0009437)3.01365874
60axonemal dynein complex assembly (GO:0070286)22.6962563
61sperm motility (GO:0030317)2.99522187
62glutathione derivative metabolic process (GO:1901685)2.98777254
63glutathione derivative biosynthetic process (GO:1901687)2.98777254
64drug catabolic process (GO:0042737)2.97801161
65phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.94148162
66hypotonic response (GO:0006971)2.93214163
67hydrogen peroxide biosynthetic process (GO:0050665)2.89747087
68determination of bilateral symmetry (GO:0009855)2.89522563
69microtubule-based process (GO:0007017)2.86268527
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83647952
71specification of symmetry (GO:0009799)2.82909175
72hydrogen peroxide catabolic process (GO:0042744)2.82797130
73retinal rod cell development (GO:0046548)2.80890860
74centriole replication (GO:0007099)2.79100060
75retinol metabolic process (GO:0042572)2.76178638
76regulation of response to osmotic stress (GO:0047484)2.71279587
77calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.67813027
78iron ion import (GO:0097286)2.61396637
79organelle assembly (GO:0070925)2.61261466
80water homeostasis (GO:0030104)2.60824708
81lateral sprouting from an epithelium (GO:0060601)2.59976034
82smoothened signaling pathway (GO:0007224)2.59742461
83excretion (GO:0007588)2.58746944
84regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.58287181
85reactive oxygen species biosynthetic process (GO:1903409)2.57250271
86carnitine transmembrane transport (GO:1902603)2.56825420
87apical protein localization (GO:0045176)2.55635703
88regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.55207250
89negative regulation of microtubule depolymerization (GO:0007026)2.52874720
90phosphatidylcholine biosynthetic process (GO:0006656)2.52616997
91regulation of autophagic vacuole assembly (GO:2000785)2.52499197
92heart looping (GO:0001947)2.51903848
93regulation of apoptotic cell clearance (GO:2000425)2.47065508
94polyol transport (GO:0015791)2.45537416
95cilium or flagellum-dependent cell motility (GO:0001539)19.2104897
96cilium movement (GO:0003341)16.4781746
97motile cilium assembly (GO:0044458)15.5029218
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.2249697
99epithelial cilium movement (GO:0003351)13.9505199
100axoneme assembly (GO:0035082)10.5227455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.70714777
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.59645081
3DROSHA_22980978_ChIP-Seq_HELA_Human3.47627331
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.31425997
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.28977271
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.81260313
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.69875150
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69762417
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.46280640
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94110248
11RUNX1_27514584_Chip-Seq_MCF-7_Human1.93518532
12SMC4_20622854_ChIP-Seq_HELA_Human1.92071304
13FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.88952186
14AHR_22903824_ChIP-Seq_MCF-7_Human1.88497380
15STAT1_20625510_ChIP-Seq_HELA_Human1.88393627
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.85866249
17SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85036141
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.83476303
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.75535296
20VDR_22108803_ChIP-Seq_LS180_Human1.74590145
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.71633041
22TP63_23658742_ChIP-Seq_EP156T_Human1.68832682
23AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.67485461
24ARNT_22903824_ChIP-Seq_MCF-7_Human1.63032643
25P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62723845
26PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.56630801
27KLF5_25053715_ChIP-Seq_YYC3_Human1.56044527
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55763049
29TP63_22573176_ChIP-Seq_HFKS_Human1.55727617
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54989615
31TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54278521
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50489012
33CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50271174
34RAD21_21589869_ChIP-Seq_MESCs_Mouse1.48077244
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48029292
36SOX2_20726797_ChIP-Seq_SW620_Human1.46372617
37ETV1_20927104_ChIP-Seq_GIST48_Human1.46328448
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44337952
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.44112361
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42962429
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42173650
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41748740
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40764550
44FOXA1_25552417_ChIP-Seq_VCAP_Human1.40325630
45PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.40127266
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.37720808
47SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37609676
48SMRT_27268052_Chip-Seq_Bcells_Human1.37480906
49GATA1_19941826_ChIP-Seq_K562_Human1.34849489
50PHF8_20622853_ChIP-Seq_HELA_Human1.34042328
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.32932475
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32813007
53TP53_18474530_ChIP-ChIP_U2OS_Human1.32394815
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31691416
55RBPJ_21746931_ChIP-Seq_IB4_Human1.24404881
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.24259233
57GATA4_25053715_ChIP-Seq_YYC3_Human1.22362393
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20319478
59CTCF_20526341_ChIP-Seq_ESCs_Human1.15960326
60CTCF_27219007_Chip-Seq_Bcells_Human1.15755276
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.15212422
62P68_20966046_ChIP-Seq_HELA_Human1.14859045
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14391485
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.13920536
65SMAD3_21741376_ChIP-Seq_HESCs_Human1.13910855
66GATA6_21074721_ChIP-Seq_CACO-2_Human1.11746243
67PHF8_20622854_ChIP-Seq_HELA_Human1.11671880
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11487922
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09842662
70RACK7_27058665_Chip-Seq_MCF-7_Human1.08934974
71FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07383513
72CREB1_26743006_Chip-Seq_LNCaP_Human1.07331228
73NFYA_21822215_ChIP-Seq_K562_Human1.06843812
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06183003
75P300_27268052_Chip-Seq_Bcells_Human1.02691761
76CEBPB_22108803_ChIP-Seq_LS180_Human1.02319743
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02271494
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.01562283
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01073421
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99771809
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99308772
82NFYB_21822215_ChIP-Seq_K562_Human0.98681368
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97356496
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96437207
85TBL1_22424771_ChIP-Seq_293T_Human0.94091374
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93128537
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93061980
88TP53_16413492_ChIP-PET_HCT116_Human0.90670740
89GATA2_19941826_ChIP-Seq_K562_Human0.90119577
90FLI1_21867929_ChIP-Seq_CD8_Mouse0.89266758
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88902523
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87869901
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87347417
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87027948
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86115746
96E2F1_20622854_ChIP-Seq_HELA_Human0.85880395
97* SOX2_21211035_ChIP-Seq_LN229_Human0.84810194
98SMAD4_21799915_ChIP-Seq_A2780_Human0.84299551
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83111258
100AR_21572438_ChIP-Seq_LNCaP_Human0.82275267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.72988132
2MP0008875_abnormal_xenobiotic_pharmacok6.43840040
3MP0002132_abnormal_respiratory_system6.08492492
4MP0002277_abnormal_respiratory_mucosa4.15470337
5MP0004043_abnormal_pH_regulation4.13747208
6MP0001984_abnormal_olfaction4.02178753
7MP0005623_abnormal_meninges_morphology3.74299674
8MP0009780_abnormal_chondrocyte_physiolo3.69324120
9MP0004133_heterotaxia3.56765806
10MP0008789_abnormal_olfactory_epithelium3.39627628
11MP0000566_synostosis2.65603201
12MP0000383_abnormal_hair_follicle2.29554884
13MP0005394_taste/olfaction_phenotype2.22804484
14MP0005499_abnormal_olfactory_system2.22804484
15MP0005377_hearing/vestibular/ear_phenot2.17257849
16MP0003878_abnormal_ear_physiology2.17257849
17MP0002168_other_aberrant_phenotype2.14380188
18MP0002282_abnormal_trachea_morphology2.10653962
19MP0003656_abnormal_erythrocyte_physiolo2.04221051
20MP0010678_abnormal_skin_adnexa2.01035517
21MP0005083_abnormal_biliary_tract1.93499485
22MP0001765_abnormal_ion_homeostasis1.90063552
23MP0002160_abnormal_reproductive_system1.84016110
24MP0004019_abnormal_vitamin_homeostasis1.78667363
25MP0000678_abnormal_parathyroid_gland1.70471137
26MP0001346_abnormal_lacrimal_gland1.63954003
27MP0002909_abnormal_adrenal_gland1.46507613
28MP0005395_other_phenotype1.41611810
29MP0005636_abnormal_mineral_homeostasis1.34255191
30MP0010234_abnormal_vibrissa_follicle1.33877196
31MP0005248_abnormal_Harderian_gland1.32532977
32MP0009379_abnormal_foot_pigmentation1.31341860
33MP0005165_increased_susceptibility_to1.30329734
34MP0010155_abnormal_intestine_physiology1.30173796
35MP0002249_abnormal_larynx_morphology1.23874429
36MP0000465_gastrointestinal_hemorrhage1.22928687
37MP0010030_abnormal_orbit_morphology1.11411691
38MP0002735_abnormal_chemical_nociception1.09190227
39MP0002734_abnormal_mechanical_nocicepti1.07842659
40MP0004264_abnormal_extraembryonic_tissu1.05898247
41MP0001849_ear_inflammation1.01977096
42MP0002876_abnormal_thyroid_physiology1.01780475
43MP0002233_abnormal_nose_morphology0.98998711
44MP0003303_peritoneal_inflammation0.94923689
45MP0002638_abnormal_pupillary_reflex0.93648689
46MP0005408_hypopigmentation0.93570659
47MP0000681_abnormal_thyroid_gland0.92236017
48MP0009643_abnormal_urine_homeostasis0.91338493
49MP0005365_abnormal_bile_salt0.89723888
50MP0005164_abnormal_response_to0.87035654
51MP0005389_reproductive_system_phenotype0.85017339
52MP0002136_abnormal_kidney_physiology0.84752126
53MP0003453_abnormal_keratinocyte_physiol0.82235329
54MP0001929_abnormal_gametogenesis0.80332393
55MP0001485_abnormal_pinna_reflex0.77703398
56MP0005310_abnormal_salivary_gland0.75734266
57MP0003698_abnormal_male_reproductive0.74488132
58MP0005220_abnormal_exocrine_pancreas0.74213178
59MP0002405_respiratory_system_inflammati0.72746071
60MP0001293_anophthalmia0.70452971
61MP0005085_abnormal_gallbladder_physiolo0.69468748
62MP0002098_abnormal_vibrissa_morphology0.69280321
63MP0002139_abnormal_hepatobiliary_system0.66746154
64MP0009765_abnormal_xenobiotic_induced0.63709998
65MP0003890_abnormal_embryonic-extraembry0.62838803
66MP0004883_abnormal_blood_vessel0.62827661
67MP0000467_abnormal_esophagus_morphology0.62315618
68MP0009046_muscle_twitch0.62093734
69MP0003075_altered_response_to0.61760215
70MP0001270_distended_abdomen0.61497232
71MP0008004_abnormal_stomach_pH0.59367423
72MP0003136_yellow_coat_color0.57473814
73MP0009703_decreased_birth_body0.57173193
74MP0006082_CNS_inflammation0.56442782
75MP0009763_increased_sensitivity_to0.55643029
76MP0003866_abnormal_defecation0.55078027
77MP0001664_abnormal_digestion0.54344538
78MP0001324_abnormal_eye_pigmentation0.53819934
79MP0001790_abnormal_immune_system0.53312422
80MP0005387_immune_system_phenotype0.53312422
81MP0002133_abnormal_respiratory_system0.53311388
82MP0005388_respiratory_system_phenotype0.53311388
83MP0001663_abnormal_digestive_system0.51248962
84MP0005023_abnormal_wound_healing0.50948641
85MP0005503_abnormal_tendon_morphology0.49672062
86MP0003941_abnormal_skin_development0.49242177
87MP0003950_abnormal_plasma_membrane0.48398375
88MP0005409_darkened_coat_color0.48220921
89MP0000858_altered_metastatic_potential0.47799491
90MP0000026_abnormal_inner_ear0.45164341
91MP0006036_abnormal_mitochondrial_physio0.44774472
92MP0002084_abnormal_developmental_patter0.44001504
93MP0001879_abnormal_lymphatic_vessel0.43791561
94MP0005253_abnormal_eye_physiology0.43670513
95MP0005166_decreased_susceptibility_to0.43193141
96MP0001299_abnormal_eye_distance/0.43115260
97MP0001666_abnormal_nutrient_absorption0.42307896
98MP0002116_abnormal_craniofacial_bone0.42056175
99MP0001944_abnormal_pancreas_morphology0.42032303
100MP0002135_abnormal_kidney_morphology0.41873077

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.94461874
2Bronchiectasis (HP:0002110)7.56409092
3Nasal polyposis (HP:0100582)6.85374472
4Abnormality of the nasal mucosa (HP:0000433)5.70255601
5Bronchitis (HP:0012387)4.46013343
6Recurrent sinusitis (HP:0011108)4.44648177
7Infertility (HP:0000789)4.29639005
8Chronic sinusitis (HP:0011109)4.17123914
9Male infertility (HP:0003251)4.06468934
10Recurrent otitis media (HP:0000403)3.99824523
11Occipital encephalocele (HP:0002085)3.48932750
12Pancreatic fibrosis (HP:0100732)3.30351298
13True hermaphroditism (HP:0010459)3.20600484
14Chronic otitis media (HP:0000389)3.11635386
15Atelectasis (HP:0100750)2.97117384
16Hyperactive renin-angiotensin system (HP:0000841)2.93771318
17Cystic liver disease (HP:0006706)2.70973375
18Molar tooth sign on MRI (HP:0002419)2.64938392
19Abnormality of midbrain morphology (HP:0002418)2.64938392
20Pancreatic cysts (HP:0001737)2.64678050
21Nephronophthisis (HP:0000090)2.55503746
22Postaxial foot polydactyly (HP:0001830)2.32380340
23Chronic hepatic failure (HP:0100626)2.30264476
24Bell-shaped thorax (HP:0001591)2.11581594
25Tubulointerstitial nephritis (HP:0001970)2.08952242
26Recurrent bronchitis (HP:0002837)2.06454977
27Absent frontal sinuses (HP:0002688)2.00131926
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6579693
29Abnormal respiratory motile cilium morphology (HP:0005938)11.4242156
30Abnormal respiratory epithelium morphology (HP:0012253)11.4242156
31Abnormal respiratory motile cilium physiology (HP:0012261)11.2279153
32Absent/shortened dynein arms (HP:0200106)11.0967857
33Dynein arm defect of respiratory motile cilia (HP:0012255)11.0967857
34Abnormal ciliary motility (HP:0012262)11.0264722
35Rhinitis (HP:0012384)10.2953868
36Abnormality of the renal medulla (HP:0100957)1.97343931
37Congenital hepatic fibrosis (HP:0002612)1.94660014
38Anencephaly (HP:0002323)1.89579446
39Aplasia/Hypoplasia of the tongue (HP:0010295)1.86081692
40Male pseudohermaphroditism (HP:0000037)1.79215122
41Asplenia (HP:0001746)1.78605328
42Medial flaring of the eyebrow (HP:0010747)1.75673298
43Renal salt wasting (HP:0000127)1.75664559
44Aplasia/Hypoplasia of the spleen (HP:0010451)1.75205167
45Decreased circulating renin level (HP:0003351)1.72353438
46Congenital primary aphakia (HP:0007707)1.64556494
47Gait imbalance (HP:0002141)1.61161431
48Oculomotor apraxia (HP:0000657)1.58361205
49Nephropathy (HP:0000112)1.58332530
50Hyperkalemia (HP:0002153)1.56127027
51Furrowed tongue (HP:0000221)1.55516662
52Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53304015
53Sclerocornea (HP:0000647)1.52916763
54Tubular atrophy (HP:0000092)1.50170347
55Postaxial hand polydactyly (HP:0001162)1.45672755
56Hyperaldosteronism (HP:0000859)1.43592503
57Nephrogenic diabetes insipidus (HP:0009806)1.42011649
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.35250968
59Abnormality of the distal phalanges of the toes (HP:0010182)1.29146131
60Abnormality of renin-angiotensin system (HP:0000847)1.29097159
61Abnormality of chloride homeostasis (HP:0011422)1.28267262
62Median cleft lip (HP:0000161)1.26719405
63Short thorax (HP:0010306)1.24807584
64Hand muscle atrophy (HP:0009130)1.24302275
65Glucose intolerance (HP:0000833)1.23540607
66Preaxial hand polydactyly (HP:0001177)1.22619034
67Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.21697557
68Abnormality of the frontal sinuses (HP:0002687)1.21523865
69Hypokalemic alkalosis (HP:0001949)1.19152286
70Short nail (HP:0001799)1.18799179
71Decreased central vision (HP:0007663)1.18433489
72Cone-rod dystrophy (HP:0000548)1.17568799
73Abnormality of permanent molar morphology (HP:0011071)1.17368533
74Abnormality of the dental root (HP:0006486)1.17368533
75Taurodontia (HP:0000679)1.17368533
76Fetal akinesia sequence (HP:0001989)1.14076706
77Vaginal atresia (HP:0000148)1.12745805
78Poor coordination (HP:0002370)1.12660307
79Tubulointerstitial abnormality (HP:0001969)1.12002904
80Genital tract atresia (HP:0001827)1.11526209
81Hyponatremia (HP:0002902)1.10580849
82Bifid scrotum (HP:0000048)1.08608842
83Abnormality of molar morphology (HP:0011070)1.07554054
84Abnormality of molar (HP:0011077)1.07554054
85Obstructive sleep apnea (HP:0002870)1.06488688
86Stage 5 chronic kidney disease (HP:0003774)1.06416807
87Muscle fiber splitting (HP:0003555)1.05578374
88Popliteal pterygium (HP:0009756)1.04747487
89Aplasia of the musculature (HP:0100854)1.04615202
90Abnormality of the dental pulp (HP:0006479)1.04015045
91Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.02809379
92Lip pit (HP:0100267)0.99406542
93Carpal bone hypoplasia (HP:0001498)0.99301743
94Flat acetabular roof (HP:0003180)0.98526848
95Short femoral neck (HP:0100864)0.98486840
96Spinal muscular atrophy (HP:0007269)0.98229478
97Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)0.97165073
98Abnormality of monocarboxylic acid metabolism (HP:0010996)0.96392560
99Facial cleft (HP:0002006)0.94192856
100Stridor (HP:0010307)0.93280099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.02834990
2EPHA24.75454385
3MAPKAPK32.33670312
4NME12.28572723
5SMG12.26798258
6MAP3K22.06204029
7STK242.05660895
8MAPK1511.8943873
9TTK1.92160719
10EEF2K1.87672093
11MAP3K31.64504680
12CSK1.53373264
13BCR1.53355680
14PTK2B1.45253286
15ERBB41.32537957
16STK101.30025652
17LRRK21.24496308
18MST1R1.15333276
19TESK11.12018201
20NEK61.10736775
21TLK11.08950910
22MAP3K71.08605613
23EPHB11.08113154
24RIPK40.98789334
25TRPM70.96827528
26TBK10.90492240
27PNCK0.88455499
28MARK20.88280534
29PRKCI0.81949373
30MAP3K120.75284184
31BRSK20.65968810
32ERBB20.65930621
33TRIB30.64482065
34CAMKK10.63531589
35EPHA30.63290170
36STK380.61363134
37ERBB30.60572654
38MYLK0.59560889
39ICK0.58618135
40CAMK2G0.58060050
41STK160.56513147
42GRK60.50701149
43PRKCQ0.49762082
44NLK0.48119476
45RPS6KB20.47868290
46PDPK10.45342899
47AURKA0.43011225
48PRKCD0.42901910
49RIPK10.41835084
50PBK0.41584184
51SGK10.41496998
52HIPK20.38668203
53PRKAA20.38533086
54PAK40.34941971
55DYRK1B0.34603036
56CDC42BPA0.34413197
57MAP3K40.31922009
58LATS10.30967212
59IRAK10.30469958
60STK38L0.28748971
61ROCK20.27642270
62TAOK10.26224004
63MAPKAPK50.25236725
64MAP2K20.24186247
65CDK60.23738183
66PLK10.23337463
67ROCK10.23003665
68INSRR0.22876089
69ABL10.22114370
70MET0.22034293
71TYK20.21656398
72FER0.21655733
73MELK0.21370903
74PAK10.21012876
75FGFR30.20707603
76LMTK20.20473588
77AKT20.19776896
78ILK0.19325725
79PRKACA0.19185628
80NEK90.18813183
81PRKCA0.18531366
82ADRBK10.17983737
83OXSR10.17915142
84FYN0.17394385
85ACVR1B0.17010327
86MAP2K40.16679286
87PASK0.16600714
88GRK10.15843607
89SRC0.14599620
90RPS6KA20.14584145
91PTK60.13405136
92DYRK1A0.12995547
93CAMK2A0.12082857
94TSSK60.11709098
95MAP3K80.11550428
96EGFR0.11168858
97PDK10.11168271
98ZAP700.11062066
99PRKDC0.09579773
100CHEK20.08633976

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.72477897
2Phenylalanine metabolism_Homo sapiens_hsa003604.94212534
3Histidine metabolism_Homo sapiens_hsa003404.70550206
4Chemical carcinogenesis_Homo sapiens_hsa052044.50918677
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.33594496
6Tyrosine metabolism_Homo sapiens_hsa003503.66535342
7beta-Alanine metabolism_Homo sapiens_hsa004103.14202311
8Huntingtons disease_Homo sapiens_hsa050163.09517286
9Glutathione metabolism_Homo sapiens_hsa004802.73021681
10Caffeine metabolism_Homo sapiens_hsa002322.72511581
11Retinol metabolism_Homo sapiens_hsa008302.29817180
12Linoleic acid metabolism_Homo sapiens_hsa005912.05715017
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94581934
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.88148201
15Sphingolipid metabolism_Homo sapiens_hsa006001.77552671
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.69358379
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69042471
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59560518
19Tight junction_Homo sapiens_hsa045301.57584254
20ABC transporters_Homo sapiens_hsa020101.52116080
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46797459
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.29600508
23Fatty acid degradation_Homo sapiens_hsa000711.28325424
24Peroxisome_Homo sapiens_hsa041461.26910254
25Starch and sucrose metabolism_Homo sapiens_hsa005001.08681974
26Salivary secretion_Homo sapiens_hsa049701.06356946
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06353639
28Arachidonic acid metabolism_Homo sapiens_hsa005901.04703642
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99558234
30Circadian rhythm_Homo sapiens_hsa047100.95710381
31Drug metabolism - other enzymes_Homo sapiens_hsa009830.91878573
32Leukocyte transendothelial migration_Homo sapiens_hsa046700.85449284
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80426698
34Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78283502
35Choline metabolism in cancer_Homo sapiens_hsa052310.75071763
36Hepatitis C_Homo sapiens_hsa051600.74993066
37Notch signaling pathway_Homo sapiens_hsa043300.72615042
38Adherens junction_Homo sapiens_hsa045200.68329712
39Glycerophospholipid metabolism_Homo sapiens_hsa005640.65297711
40Hematopoietic cell lineage_Homo sapiens_hsa046400.61509693
41Taste transduction_Homo sapiens_hsa047420.60573731
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58235364
43Complement and coagulation cascades_Homo sapiens_hsa046100.56254810
44PPAR signaling pathway_Homo sapiens_hsa033200.52420302
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51613368
46Olfactory transduction_Homo sapiens_hsa047400.51042238
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.50208175
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50164251
49Collecting duct acid secretion_Homo sapiens_hsa049660.50010090
50Hedgehog signaling pathway_Homo sapiens_hsa043400.46635744
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.45199588
52Vitamin digestion and absorption_Homo sapiens_hsa049770.43821819
53Amoebiasis_Homo sapiens_hsa051460.43539783
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39269854
55Basal cell carcinoma_Homo sapiens_hsa052170.35586952
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34636509
57Pyruvate metabolism_Homo sapiens_hsa006200.32451262
58Arginine and proline metabolism_Homo sapiens_hsa003300.31171812
59cAMP signaling pathway_Homo sapiens_hsa040240.30668823
60Metabolic pathways_Homo sapiens_hsa011000.28961808
61Type I diabetes mellitus_Homo sapiens_hsa049400.27346074
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26841247
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26082165
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25811286
65Calcium signaling pathway_Homo sapiens_hsa040200.25691756
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25148473
67Lysosome_Homo sapiens_hsa041420.24858192
68Allograft rejection_Homo sapiens_hsa053300.24344776
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.24110346
70Autoimmune thyroid disease_Homo sapiens_hsa053200.22457871
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.22064790
72Serotonergic synapse_Homo sapiens_hsa047260.21921698
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21569185
74Glycerolipid metabolism_Homo sapiens_hsa005610.21394133
75Cocaine addiction_Homo sapiens_hsa050300.20875259
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20116466
77Phototransduction_Homo sapiens_hsa047440.18547022
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18376592
79Fatty acid biosynthesis_Homo sapiens_hsa000610.18257751
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16519937
81Graft-versus-host disease_Homo sapiens_hsa053320.16379060
82Hippo signaling pathway_Homo sapiens_hsa043900.16099074
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15893920
84Pancreatic secretion_Homo sapiens_hsa049720.15739176
85Asthma_Homo sapiens_hsa053100.15705432
86Insulin resistance_Homo sapiens_hsa049310.15528247
87Endocytosis_Homo sapiens_hsa041440.11577438
88Dilated cardiomyopathy_Homo sapiens_hsa054140.11009850
89Nicotine addiction_Homo sapiens_hsa050330.10363860
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.10205607
91Phagosome_Homo sapiens_hsa041450.09173570
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08790482
93Amphetamine addiction_Homo sapiens_hsa050310.07986277
94Antigen processing and presentation_Homo sapiens_hsa046120.07505988
95Butanoate metabolism_Homo sapiens_hsa006500.06474228
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06315566
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05141418
98Tryptophan metabolism_Homo sapiens_hsa003800.05067187
99Gastric acid secretion_Homo sapiens_hsa049710.04459717
100Bile secretion_Homo sapiens_hsa049760.03936962

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »