WFDC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.72574373
2fusion of sperm to egg plasma membrane (GO:0007342)9.27815528
3positive regulation of antigen processing and presentation (GO:0002579)8.93974066
4regulation of acrosome reaction (GO:0060046)8.86052265
5regulation of clathrin-mediated endocytosis (GO:2000369)7.38497417
6regulation of antigen processing and presentation (GO:0002577)7.22884344
7plasma membrane fusion (GO:0045026)7.11170024
8regulation of T cell tolerance induction (GO:0002664)6.57251417
9production of molecular mediator involved in inflammatory response (GO:0002532)6.23900269
10behavioral response to nicotine (GO:0035095)5.88665129
11kynurenine metabolic process (GO:0070189)5.70877228
12positive regulation of tolerance induction (GO:0002645)5.66532647
13complement activation, alternative pathway (GO:0006957)5.53706172
14regulation of tolerance induction (GO:0002643)4.87329343
15DNA deamination (GO:0045006)4.72007088
16negative regulation of receptor-mediated endocytosis (GO:0048261)4.65898508
17sperm capacitation (GO:0048240)4.57857284
18platelet dense granule organization (GO:0060155)4.48030326
19sulfur amino acid catabolic process (GO:0000098)4.32374077
20indole-containing compound catabolic process (GO:0042436)4.22474206
21indolalkylamine catabolic process (GO:0046218)4.22474206
22tryptophan catabolic process (GO:0006569)4.22474206
23macroautophagy (GO:0016236)4.16856448
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.15121869
25cellular ketone body metabolic process (GO:0046950)4.05337370
26regulation of chronic inflammatory response (GO:0002676)3.83759429
27L-fucose catabolic process (GO:0042355)3.79964906
28fucose catabolic process (GO:0019317)3.79964906
29L-fucose metabolic process (GO:0042354)3.79964906
30pyrimidine ribonucleoside catabolic process (GO:0046133)3.67408256
31tryptophan metabolic process (GO:0006568)3.63417617
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60213651
33eye photoreceptor cell differentiation (GO:0001754)3.58234468
34photoreceptor cell differentiation (GO:0046530)3.58234468
35ketone body metabolic process (GO:1902224)3.56568652
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53449594
37nephron tubule morphogenesis (GO:0072078)3.48944250
38nephron epithelium morphogenesis (GO:0072088)3.48944250
39mannosylation (GO:0097502)3.47502138
40regulation of calcium ion-dependent exocytosis (GO:0017158)3.46666146
41alpha-linolenic acid metabolic process (GO:0036109)3.42138847
42negative regulation of telomere maintenance (GO:0032205)3.41622570
43cellular sodium ion homeostasis (GO:0006883)3.38247096
44NADH dehydrogenase complex assembly (GO:0010257)3.38227529
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38227529
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.38227529
47single fertilization (GO:0007338)3.36467744
48epithelial cilium movement (GO:0003351)3.36173494
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32087686
50ATP synthesis coupled proton transport (GO:0015986)3.32087686
51negative regulation of interleukin-10 production (GO:0032693)3.31824108
52regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.29704665
53protein complex biogenesis (GO:0070271)3.29630977
54epithelial cell differentiation involved in kidney development (GO:0035850)3.28529761
55regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.27449755
56response to misfolded protein (GO:0051788)3.25748755
57piRNA metabolic process (GO:0034587)3.25315966
58preassembly of GPI anchor in ER membrane (GO:0016254)3.22215116
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20337487
60kidney morphogenesis (GO:0060993)3.19142845
61regulation of hexokinase activity (GO:1903299)3.18944084
62regulation of glucokinase activity (GO:0033131)3.18944084
63positive regulation of type 2 immune response (GO:0002830)3.17471070
64regulation of Cdc42 GTPase activity (GO:0043088)3.17015263
65cytolysis (GO:0019835)3.14801319
66water-soluble vitamin biosynthetic process (GO:0042364)3.13948036
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13653863
68regulation of complement activation (GO:0030449)3.13073803
69negative regulation of protein autophosphorylation (GO:0031953)3.10650996
70cytidine metabolic process (GO:0046087)3.09807456
71cytidine catabolic process (GO:0006216)3.09807456
72cytidine deamination (GO:0009972)3.09807456
73protein-cofactor linkage (GO:0018065)3.09642833
74neuron fate determination (GO:0048664)3.06928307
75* negative regulation of endopeptidase activity (GO:0010951)3.06728233
76benzene-containing compound metabolic process (GO:0042537)3.06548107
77indole-containing compound metabolic process (GO:0042430)3.04142813
78heterotypic cell-cell adhesion (GO:0034113)3.03681387
79detection of light stimulus involved in visual perception (GO:0050908)3.02922784
80detection of light stimulus involved in sensory perception (GO:0050962)3.02922784
81regulation of protein activation cascade (GO:2000257)3.02078814
82aromatic amino acid family catabolic process (GO:0009074)3.00435594
83regulation of activation of Janus kinase activity (GO:0010533)2.99566050
84positive regulation of defense response to virus by host (GO:0002230)2.99427156
85cilium or flagellum-dependent cell motility (GO:0001539)2.98681325
86valine metabolic process (GO:0006573)2.98256280
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97651798
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97651798
89mitochondrial respiratory chain complex assembly (GO:0033108)2.97174839
90phospholipid homeostasis (GO:0055091)2.97132509
91regulation of cilium movement (GO:0003352)2.94445541
92multicellular organism reproduction (GO:0032504)2.94168629
93* negative regulation of peptidase activity (GO:0010466)2.93910172
94respiratory chain complex IV assembly (GO:0008535)2.91702078
95protein K6-linked ubiquitination (GO:0085020)2.91611802
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84292064
97synaptic transmission, cholinergic (GO:0007271)2.82470804
98protein polyglutamylation (GO:0018095)2.80402379
99sulfation (GO:0051923)2.80386637
100primary amino compound metabolic process (GO:1901160)2.79339015
101positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.78959757
102cilium movement (GO:0003341)2.77845198
103gamma-aminobutyric acid transport (GO:0015812)2.77686888
104mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77318066
105negative regulation of mast cell activation (GO:0033004)2.74730728
106reverse cholesterol transport (GO:0043691)2.74361052
107positive regulation of fatty acid transport (GO:2000193)2.73918987
108dopamine transport (GO:0015872)2.72357739
109behavioral response to ethanol (GO:0048149)2.70900177
110regulation of action potential (GO:0098900)2.70586546
111cysteine metabolic process (GO:0006534)2.70563067
112ubiquinone biosynthetic process (GO:0006744)2.69764110
113amine catabolic process (GO:0009310)2.69457958
114cellular biogenic amine catabolic process (GO:0042402)2.69457958
115serotonin metabolic process (GO:0042428)2.66240224
116GPI anchor biosynthetic process (GO:0006506)2.65827118
117regulation of mesoderm development (GO:2000380)2.65555133
118regulation of lipoprotein metabolic process (GO:0050746)2.64490805
119cAMP catabolic process (GO:0006198)2.63635085
120axonemal dynein complex assembly (GO:0070286)2.63034743
121RNA destabilization (GO:0050779)2.61752716
122sequestering of actin monomers (GO:0042989)2.61705835
123axoneme assembly (GO:0035082)2.61591447
124GPI anchor metabolic process (GO:0006505)2.60498330
125amino acid salvage (GO:0043102)2.58632251
126L-methionine salvage (GO:0071267)2.58632251
127L-methionine biosynthetic process (GO:0071265)2.58632251
128regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57170363
129rhodopsin mediated signaling pathway (GO:0016056)2.57108438
130indolalkylamine metabolic process (GO:0006586)2.57011182
131somite development (GO:0061053)2.56826803
132cilium morphogenesis (GO:0060271)2.55427506
133nonmotile primary cilium assembly (GO:0035058)2.55201336
134cornea development in camera-type eye (GO:0061303)2.54943423
135ubiquinone metabolic process (GO:0006743)2.54335042
136ethanol oxidation (GO:0006069)2.54205028
137neuronal action potential (GO:0019228)2.53426858
138negative regulation by host of viral transcription (GO:0043922)2.53215426
139response to nitrosative stress (GO:0051409)2.52390707
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.51871788
141regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.51487308
142renal tubule morphogenesis (GO:0061333)2.51367193
143S-adenosylmethionine metabolic process (GO:0046500)2.51005440
144cytochrome complex assembly (GO:0017004)2.50423195
145positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.49915421
146electron transport chain (GO:0022900)2.47166691
147male meiosis I (GO:0007141)2.46772360
148endoderm formation (GO:0001706)2.46316933
149regulation of hydrogen peroxide metabolic process (GO:0010310)2.44573763
150triglyceride catabolic process (GO:0019433)2.43091616
151proton transport (GO:0015992)2.43074372
152regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.42993756
153binding of sperm to zona pellucida (GO:0007339)2.42028515
154low-density lipoprotein particle clearance (GO:0034383)2.41874074
155linoleic acid metabolic process (GO:0043651)2.41076790
156negative regulation of metanephros development (GO:0072217)2.40692240
157high-density lipoprotein particle remodeling (GO:0034375)2.36080920
158sodium ion homeostasis (GO:0055078)2.34480302
159aromatic amino acid family metabolic process (GO:0009072)2.34211917
160acylglycerol catabolic process (GO:0046464)2.29362326
161neutral lipid catabolic process (GO:0046461)2.29362326
162complement activation, classical pathway (GO:0006958)2.28513893
163fertilization (GO:0009566)2.28361827
164positive regulation of cholesterol transport (GO:0032376)2.27387551
165positive regulation of sterol transport (GO:0032373)2.27387551
166negative regulation of lipase activity (GO:0060192)2.25218094
167negative regulation of endocytosis (GO:0045806)2.23155189
168collecting duct development (GO:0072044)2.22038614
169metanephric tubule development (GO:0072170)2.19118863
170metanephric nephron tubule development (GO:0072234)2.19118863
171nerve growth factor signaling pathway (GO:0038180)2.17636685
172complement activation (GO:0006956)2.15044712
173nucleoside diphosphate catabolic process (GO:0009134)2.13427024
174mannose metabolic process (GO:0006013)2.13155758
175regulation of hydrogen peroxide-induced cell death (GO:1903205)2.12670723
176negative regulation of T cell apoptotic process (GO:0070233)2.05836758
177* negative regulation of proteolysis (GO:0045861)2.05634308
178Golgi transport vesicle coating (GO:0048200)2.05267877
179COPI coating of Golgi vesicle (GO:0048205)2.05267877
180respiratory burst (GO:0045730)2.04473516
181positive regulation of glomerulus development (GO:0090193)2.03867826
182antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)19.6887677
183antigen processing and presentation of endogenous peptide antigen (GO:0002483)19.6887677
184antigen processing and presentation via MHC class Ib (GO:0002475)18.8620649
185regulation of antigen processing and presentation of peptide antigen (GO:0002583)18.1833035
186antigen processing and presentation of endogenous antigen (GO:0019883)16.3331296
187ethanol metabolic process (GO:0006067)1.98400357
188regulation of lipoprotein particle clearance (GO:0010984)1.98085225
189metanephric nephron epithelium development (GO:0072243)1.98016733
190* negative regulation of protein processing (GO:0010955)1.97846248
191* negative regulation of protein maturation (GO:1903318)1.97846248
192negative regulation of glycogen biosynthetic process (GO:0045719)1.97328336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.56502234
2AR_21572438_ChIP-Seq_LNCaP_Human3.44046353
3EZH2_22144423_ChIP-Seq_EOC_Human3.37753882
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.21683125
5VDR_22108803_ChIP-Seq_LS180_Human3.17592772
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.89371029
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75063434
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.65904115
9ZNF263_19887448_ChIP-Seq_K562_Human2.54925424
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.41432224
11GBX2_23144817_ChIP-Seq_PC3_Human2.39019480
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38877839
13IGF1R_20145208_ChIP-Seq_DFB_Human2.36271682
14FUS_26573619_Chip-Seq_HEK293_Human2.26593470
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19022306
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11236211
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06845480
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03248551
19GATA1_22025678_ChIP-Seq_K562_Human12.1429807
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98595937
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.94783391
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.94414857
23P300_19829295_ChIP-Seq_ESCs_Human1.93071631
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91213528
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86397748
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85590307
27IRF1_19129219_ChIP-ChIP_H3396_Human1.85155936
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.83123738
29EWS_26573619_Chip-Seq_HEK293_Human1.79627272
30CLOCK_20551151_ChIP-Seq_293T_Human1.78973426
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72715332
32ER_23166858_ChIP-Seq_MCF-7_Human1.70041060
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.69398926
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67697104
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66293981
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65399123
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.62068441
38BCAT_22108803_ChIP-Seq_LS180_Human1.57763862
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55731722
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.53562716
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.52994910
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52196821
43TP53_22573176_ChIP-Seq_HFKS_Human1.50812465
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48935751
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48699925
46MYC_19915707_ChIP-ChIP_AK7_Human1.48602966
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48289245
48NANOG_19829295_ChIP-Seq_ESCs_Human1.48165963
49SOX2_19829295_ChIP-Seq_ESCs_Human1.48165963
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42034784
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41497968
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39344468
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38596119
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.38322864
55MYC_18940864_ChIP-ChIP_HL60_Human1.37589306
56* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37356791
57REST_21632747_ChIP-Seq_MESCs_Mouse1.36040276
58ZNF274_21170338_ChIP-Seq_K562_Hela1.33866738
59STAT1_17558387_ChIP-Seq_HELA_Human1.32673498
60SMAD4_21741376_ChIP-Seq_HESCs_Human1.31894695
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.31416188
62RNF2_27304074_Chip-Seq_NSC_Mouse1.31387311
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30763313
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.30763313
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30640781
66AR_25329375_ChIP-Seq_VCAP_Human1.30067145
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29929079
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29905941
69ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26818673
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25980957
71AR_20517297_ChIP-Seq_VCAP_Human1.25323748
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24797535
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22561008
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22443978
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22394457
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22394457
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.21708743
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.20797017
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20503618
80AHR_22903824_ChIP-Seq_MCF-7_Human1.20416887
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.20069622
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19534730
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19312527
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18625350
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.18592974
86TCF4_22108803_ChIP-Seq_LS180_Human1.17347793
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.17014043
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16839245
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16839245
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16011256
91STAT3_23295773_ChIP-Seq_U87_Human1.15798056
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15204879
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15081160
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14986891
95CBP_20019798_ChIP-Seq_JUKART_Human1.14986891
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13935697
97SOX2_20726797_ChIP-Seq_SW620_Human1.13854093
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.12978547
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12592862
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11551242
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11003550
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.10735076
103VDR_24787735_ChIP-Seq_THP-1_Human1.10334896
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06487482
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06270055
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.05530107
107VDR_23849224_ChIP-Seq_CD4+_Human1.05132847
108NCOR_22424771_ChIP-Seq_293T_Human1.04906271
109TCF4_23295773_ChIP-Seq_U87_Human1.04536463
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03852736
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03555239
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03448112
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02618002
114RUNX2_22187159_ChIP-Seq_PCA_Human1.02554250
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02469223
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02446822
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02091085
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02059886
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.01764224
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00900206
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00858085
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.99531193
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.99460376
124P53_22387025_ChIP-Seq_ESCs_Mouse0.97631713
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97443967
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97293455
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97029031
128FOXH1_21741376_ChIP-Seq_ESCs_Human0.96987614
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.96478366
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96348008
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96129178
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.95893230
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95744215
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95610245
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94990988
136SALL1_21062744_ChIP-ChIP_HESCs_Human0.94971441
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.94925278
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94226535
139SMAD4_21799915_ChIP-Seq_A2780_Human0.94082054
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93436966
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92572090
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90506678
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.89556092
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89404411
145LXR_22292898_ChIP-Seq_THP-1_Human0.89167875
146* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89049418
147NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88690827
148KDM2B_26808549_Chip-Seq_REH_Human0.88262410
149OCT1_27270436_Chip-Seq_PROSTATE_Human0.87818041
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.87382719
151SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87337544
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87021350
153TAF15_26573619_Chip-Seq_HEK293_Human0.86408967
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84709794
155GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84200623
156DROSHA_22980978_ChIP-Seq_HELA_Human0.83960867
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83288179
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83254290
159HTT_18923047_ChIP-ChIP_STHdh_Human0.83187635
160CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82866778
161PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82783828
162OCT4_20526341_ChIP-Seq_ESCs_Human0.82122510
163MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81328010
164BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81217745
165CEBPB_22108803_ChIP-Seq_LS180_Human0.81131826
166GATA3_21867929_ChIP-Seq_TH1_Mouse0.80545104
167SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80271221
168SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79948256
169P68_20966046_ChIP-Seq_HELA_Human0.78659100
170TAF2_19829295_ChIP-Seq_ESCs_Human0.77567267
171PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77443932
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.77086867
173MYC_27129775_Chip-Seq_CORNEA_Mouse0.76501536
174PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76500470
175SMC4_20622854_ChIP-Seq_HELA_Human0.75643986
176EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75643760
177FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75329396
178RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74159899
179RAC3_21632823_ChIP-Seq_H3396_Human0.72823404
180SMAD4_21741376_ChIP-Seq_EPCs_Human0.71679208
181TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.71060042
182SMRT_27268052_Chip-Seq_Bcells_Human0.70325148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.21357268
2MP0002139_abnormal_hepatobiliary_system4.05410285
3MP0003195_calcinosis4.02654056
4MP0010234_abnormal_vibrissa_follicle3.51480647
5MP0003300_gastrointestinal_ulcer3.21581903
6MP0008877_abnormal_DNA_methylation3.04339406
7MP0002254_reproductive_system_inflammat2.90217222
8MP0004043_abnormal_pH_regulation2.87197567
9MP0005410_abnormal_fertilization2.83946675
10MP0003878_abnormal_ear_physiology2.81233987
11MP0005377_hearing/vestibular/ear_phenot2.81233987
12MP0006072_abnormal_retinal_apoptosis2.67597100
13MP0005551_abnormal_eye_electrophysiolog2.53486265
14MP0002102_abnormal_ear_morphology2.50895164
15MP0002638_abnormal_pupillary_reflex2.48986527
16MP0005670_abnormal_white_adipose2.46626358
17MP0002138_abnormal_hepatobiliary_system2.39807865
18MP0005275_abnormal_skin_tensile2.37302274
19MP0003136_yellow_coat_color2.24911715
20MP0003303_peritoneal_inflammation2.23930892
21MP0010329_abnormal_lipoprotein_level2.21341663
22MP0001968_abnormal_touch/_nociception2.16271624
23MP0005084_abnormal_gallbladder_morpholo2.11398832
24MP0003705_abnormal_hypodermis_morpholog2.08540464
25MP0008438_abnormal_cutaneous_collagen2.08109747
26MP0000003_abnormal_adipose_tissue2.07247956
27MP0008872_abnormal_physiological_respon2.06618545
28MP0005645_abnormal_hypothalamus_physiol2.05332252
29MP0001986_abnormal_taste_sensitivity2.01510579
30MP0005375_adipose_tissue_phenotype1.96994899
31MP0006292_abnormal_olfactory_placode1.96197388
32MP0003880_abnormal_central_pattern1.92415312
33MP0004019_abnormal_vitamin_homeostasis1.88860886
34MP0005253_abnormal_eye_physiology1.88376545
35MP0001765_abnormal_ion_homeostasis1.86804105
36MP0005365_abnormal_bile_salt1.86586053
37MP0009745_abnormal_behavioral_response1.86576042
38MP0004142_abnormal_muscle_tone1.85510420
39MP0005666_abnormal_adipose_tissue1.81093879
40MP0002277_abnormal_respiratory_mucosa1.80668133
41MP0004147_increased_porphyrin_level1.79810283
42MP0000569_abnormal_digit_pigmentation1.79719389
43MP0004858_abnormal_nervous_system1.74083158
44MP0005646_abnormal_pituitary_gland1.73278411
45MP0004130_abnormal_muscle_cell1.68020611
46MP0005636_abnormal_mineral_homeostasis1.67628203
47MP0009379_abnormal_foot_pigmentation1.65808669
48MP0003252_abnormal_bile_duct1.63488401
49MP0003646_muscle_fatigue1.63410063
50MP0004133_heterotaxia1.61358258
51MP0002168_other_aberrant_phenotype1.60838038
52MP0002272_abnormal_nervous_system1.58532682
53MP0004145_abnormal_muscle_electrophysio1.58329864
54MP0002928_abnormal_bile_duct1.54587759
55MP0004185_abnormal_adipocyte_glucose1.54581780
56MP0010386_abnormal_urinary_bladder1.50213690
57MP0009046_muscle_twitch1.49318245
58MP0006276_abnormal_autonomic_nervous1.48625046
59MP0001486_abnormal_startle_reflex1.45287909
60MP0004885_abnormal_endolymph1.45021323
61MP0002876_abnormal_thyroid_physiology1.44678261
62MP0001756_abnormal_urination1.44479975
63MP0009643_abnormal_urine_homeostasis1.43889667
64MP0003011_delayed_dark_adaptation1.43170217
65MP0009384_cardiac_valve_regurgitation1.37793857
66MP0005360_urolithiasis1.37619199
67MP0001919_abnormal_reproductive_system1.37198724
68MP0000631_abnormal_neuroendocrine_gland1.36170074
69MP0009780_abnormal_chondrocyte_physiolo1.35954019
70MP0003045_fibrosis1.35777333
71MP0003183_abnormal_peptide_metabolism1.35382234
72MP0003698_abnormal_male_reproductive1.34730725
73MP0000427_abnormal_hair_cycle1.34139068
74MP0003787_abnormal_imprinting1.33354186
75MP0002572_abnormal_emotion/affect_behav1.32267638
76MP0005389_reproductive_system_phenotype1.32214890
77MP0001529_abnormal_vocalization1.31781303
78MP0001984_abnormal_olfaction1.31669602
79MP0005174_abnormal_tail_pigmentation1.31612503
80MP0002938_white_spotting1.30648252
81MP0001501_abnormal_sleep_pattern1.29375844
82MP0001958_emphysema1.28946948
83MP0001502_abnormal_circadian_rhythm1.28059910
84MP0002118_abnormal_lipid_homeostasis1.28000986
85MP0005085_abnormal_gallbladder_physiolo1.26821470
86MP0008004_abnormal_stomach_pH1.26094780
87MP0002095_abnormal_skin_pigmentation1.24811749
88MP0005332_abnormal_amino_acid1.24221946
89MP0010678_abnormal_skin_adnexa1.23428217
90MP0003879_abnormal_hair_cell1.21595294
91MP0001485_abnormal_pinna_reflex1.21229546
92MP0000537_abnormal_urethra_morphology1.20785711
93MP0002557_abnormal_social/conspecific_i1.19508328
94MP0000372_irregular_coat_pigmentation1.19294886
95MP0002064_seizures1.19111853
96MP0005195_abnormal_posterior_eye1.18988050
97MP0003566_abnormal_cell_adhesion1.18583082
98MP0004272_abnormal_basement_membrane1.15355927
99MP0001970_abnormal_pain_threshold1.14566349
100MP0009763_increased_sensitivity_to1.14223322
101MP0003191_abnormal_cellular_cholesterol1.14020077
102MP0002009_preneoplasia1.13392091
103MP0003283_abnormal_digestive_organ1.11108842
104MP0002735_abnormal_chemical_nociception1.10693106
105MP0005584_abnormal_enzyme/coenzyme_acti1.09505907
106MP0001764_abnormal_homeostasis1.09415280
107MP0001177_atelectasis1.09379160
108MP0004742_abnormal_vestibular_system1.08700967
109MP0001905_abnormal_dopamine_level1.05942718
110MP0001188_hyperpigmentation1.05780815
111MP0002733_abnormal_thermal_nociception1.05412542
112MP0005423_abnormal_somatic_nervous1.04541042
113MP0003690_abnormal_glial_cell1.03940358
114MP0005167_abnormal_blood-brain_barrier1.02417449
115MP0001666_abnormal_nutrient_absorption1.02311932
116MP0002063_abnormal_learning/memory/cond1.00964919
117MP0002837_dystrophic_cardiac_calcinosis0.99512808
118MP0004270_analgesia0.99479138
119MP0000026_abnormal_inner_ear0.99334857
120MP0002136_abnormal_kidney_physiology0.98990646
121MP0002295_abnormal_pulmonary_circulatio0.97445343
122MP0003119_abnormal_digestive_system0.97276293
123MP0002166_altered_tumor_susceptibility0.97070024
124MP0003638_abnormal_response/metabolism_0.96585612
125MP0009764_decreased_sensitivity_to0.95833690
126MP0002160_abnormal_reproductive_system0.95629914
127MP0000609_abnormal_liver_physiology0.94406427
128MP0002971_abnormal_brown_adipose0.92533401
129MP0000604_amyloidosis0.91498628
130MP0005671_abnormal_response_to0.91078038
131MP0002282_abnormal_trachea_morphology0.89633415
132MP0000383_abnormal_hair_follicle0.89055074
133MP0002163_abnormal_gland_morphology0.88927089
134MP0003632_abnormal_nervous_system0.88790343
135MP0003635_abnormal_synaptic_transmissio0.87722960
136MP0001440_abnormal_grooming_behavior0.87378248
137MP0008995_early_reproductive_senescence0.87012200
138MP0003075_altered_response_to0.86394959
139MP0000647_abnormal_sebaceous_gland0.85823783
140MP0002752_abnormal_somatic_nervous0.84438257
141MP0003866_abnormal_defecation0.84082739
142MP0002067_abnormal_sensory_capabilities0.83869071
143MP0002184_abnormal_innervation0.83739137
144MP0002653_abnormal_ependyma_morphology0.82573782
145MP0002796_impaired_skin_barrier0.82376949
146MP0005379_endocrine/exocrine_gland_phen0.82055110
147MP0008058_abnormal_DNA_repair0.81793310
148MP0000462_abnormal_digestive_system0.81530521
149MP0002751_abnormal_autonomic_nervous0.81182777
150MP0005334_abnormal_fat_pad0.81169374
151MP0003329_amyloid_beta_deposits0.80415007
152MP0004264_abnormal_extraembryonic_tissu0.80306434
153MP0008775_abnormal_heart_ventricle0.79593115
154MP0002909_abnormal_adrenal_gland0.79429059
155MP0002896_abnormal_bone_mineralization0.77695212
156MP0001293_anophthalmia0.76804073
157MP0008875_abnormal_xenobiotic_pharmacok0.76337648
158MP0005319_abnormal_enzyme/_coenzyme0.75522581
159MP0005386_behavior/neurological_phenoty0.75250323
160MP0004924_abnormal_behavior0.75250323
161MP0001963_abnormal_hearing_physiology0.75161795
162MP0001661_extended_life_span0.71911269
163MP0004036_abnormal_muscle_relaxation0.70887866
164MP0002693_abnormal_pancreas_physiology0.70181716
165MP0005408_hypopigmentation0.68290172
166MP0001853_heart_inflammation0.68154181
167MP0000467_abnormal_esophagus_morphology0.66306208
168MP0000534_abnormal_ureter_morphology0.66183597
169MP0000230_abnormal_systemic_arterial0.65427016
170MP0002234_abnormal_pharynx_morphology0.64234816
171MP0002736_abnormal_nociception_after0.63648868
172MP0000538_abnormal_urinary_bladder0.62530314
173MP0002006_tumorigenesis0.59842739
174MP0005395_other_phenotype0.59725439
175MP0000751_myopathy0.59488066
176MP0006138_congestive_heart_failure0.59409041
177MP0009115_abnormal_fat_cell0.59319939
178MP0002229_neurodegeneration0.57179285
179MP0002161_abnormal_fertility/fecundity0.56720362
180MP0003959_abnormal_lean_body0.55410763

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)7.56001332
2Choroideremia (HP:0001139)6.05801313
3Recurrent gram-negative bacterial infections (HP:0005420)5.74538250
4Potter facies (HP:0002009)5.73066419
5Facial shape deformation (HP:0011334)5.73066419
6Abnormality of complement system (HP:0005339)5.36240711
7Abnormality of the fovea (HP:0000493)5.23156957
8Central scotoma (HP:0000603)5.11442830
9Vascular calcification (HP:0004934)4.86127878
10Abnormal rod and cone electroretinograms (HP:0008323)4.73888751
11Action tremor (HP:0002345)4.65567893
12Pancreatic cysts (HP:0001737)4.60872442
13Cardiovascular calcification (HP:0011915)4.58408205
14Abnormality of macular pigmentation (HP:0008002)4.46316768
15Hypophosphatemic rickets (HP:0004912)4.31340529
16Vacuolated lymphocytes (HP:0001922)4.30062078
17Bony spicule pigmentary retinopathy (HP:0007737)4.26717682
18Type II lissencephaly (HP:0007260)4.24167788
19Myocardial infarction (HP:0001658)4.16714556
20Congenital stationary night blindness (HP:0007642)4.14252250
21Pancreatic fibrosis (HP:0100732)4.13468003
22True hermaphroditism (HP:0010459)4.03063993
23Cone-rod dystrophy (HP:0000548)3.95767817
24Intention tremor (HP:0002080)3.91135460
25Dyschromatopsia (HP:0007641)3.87700409
2611 pairs of ribs (HP:0000878)3.85065032
27Molar tooth sign on MRI (HP:0002419)3.84420060
28Abnormality of midbrain morphology (HP:0002418)3.84420060
29Hypopigmentation of the fundus (HP:0007894)3.78124697
30Tubulointerstitial fibrosis (HP:0005576)3.61784365
31Proximal tubulopathy (HP:0000114)3.61390796
32Metaphyseal cupping (HP:0003021)3.46045487
33Nephronophthisis (HP:0000090)3.41034156
34Osteomalacia (HP:0002749)3.19168781
35Hand muscle atrophy (HP:0009130)3.17590683
36Pendular nystagmus (HP:0012043)3.13425793
37Keratoconus (HP:0000563)3.00838102
38Increased corneal curvature (HP:0100692)3.00838102
39Degeneration of the lateral corticospinal tracts (HP:0002314)3.00084347
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.00084347
41Hyperphosphatemia (HP:0002905)2.98248045
42Congenital, generalized hypertrichosis (HP:0004540)2.92650374
43Abnormality of the renal medulla (HP:0100957)2.84805719
44Chronic hepatic failure (HP:0100626)2.84327224
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.82778911
46Absent/shortened dynein arms (HP:0200106)2.82778911
47Infantile muscular hypotonia (HP:0008947)2.80426483
48Cystic liver disease (HP:0006706)2.77493644
49Medial flaring of the eyebrow (HP:0010747)2.74769586
50Abnormality of the renal cortex (HP:0011035)2.73852129
51Abnormal drinking behavior (HP:0030082)2.72542245
52Polydipsia (HP:0001959)2.72542245
53Macular degeneration (HP:0000608)2.72425185
54Decreased central vision (HP:0007663)2.71960909
55Focal segmental glomerulosclerosis (HP:0000097)2.71555435
56Missing ribs (HP:0000921)2.70964469
57Facial diplegia (HP:0001349)2.70154076
58Attenuation of retinal blood vessels (HP:0007843)2.67329650
59Scotoma (HP:0000575)2.67309209
60Lipid accumulation in hepatocytes (HP:0006561)2.65892923
61Thin bony cortex (HP:0002753)2.61012230
62Abnormal respiratory epithelium morphology (HP:0012253)2.60724460
63Abnormal respiratory motile cilium morphology (HP:0005938)2.60724460
64Abnormality of the calcaneus (HP:0008364)2.59781100
65Sclerocornea (HP:0000647)2.57421361
66Upper limb amyotrophy (HP:0009129)2.57346758
67Distal upper limb amyotrophy (HP:0007149)2.57346758
68Polar cataract (HP:0010696)2.57175454
69Bicornuate uterus (HP:0000813)2.54462383
70Lissencephaly (HP:0001339)2.52624250
71Duplicated collecting system (HP:0000081)2.48337793
72Rickets (HP:0002748)2.47983316
73Acute necrotizing encephalopathy (HP:0006965)2.47612837
74Hyperglycinuria (HP:0003108)2.47579273
75Mitochondrial inheritance (HP:0001427)2.46401312
76Cerebellar dysplasia (HP:0007033)2.44851148
77Neurofibrillary tangles (HP:0002185)2.44127086
78Agitation (HP:0000713)2.43697429
79Stridor (HP:0010307)2.43670697
80Large for gestational age (HP:0001520)2.39420268
81Chorioretinal atrophy (HP:0000533)2.39089107
82Abnormality of alanine metabolism (HP:0010916)2.37930227
83Hyperalaninemia (HP:0003348)2.37930227
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37930227
85Cerebral inclusion bodies (HP:0100314)2.35425642
86Abnormality of the pons (HP:0007361)2.34039536
87Tubular atrophy (HP:0000092)2.33095094
88Aplasia/hypoplasia of the uterus (HP:0008684)2.32355824
89Progressive visual loss (HP:0000529)2.30355288
90Subcapsular cataract (HP:0000523)2.30175803
91Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29612407
92Increased hepatocellular lipid droplets (HP:0006565)2.29456889
93Stomach cancer (HP:0012126)2.29446099
94Hypothermia (HP:0002045)2.29013958
95Increased CSF lactate (HP:0002490)2.27548968
96Hyperglycinemia (HP:0002154)2.25922282
97Malnutrition (HP:0004395)2.20786455
98Acute encephalopathy (HP:0006846)2.19958971
99Skin nodule (HP:0200036)2.19751276
100Abnormal ciliary motility (HP:0012262)2.19598357
101Pachygyria (HP:0001302)2.19270329
102Hemiplegia (HP:0002301)2.18625477
103Ketoacidosis (HP:0001993)2.18176492
104Retinal dysplasia (HP:0007973)2.17566731
105Anencephaly (HP:0002323)2.16680967
106Bile duct proliferation (HP:0001408)2.16514406
107Abnormal biliary tract physiology (HP:0012439)2.16514406
108Concave nail (HP:0001598)2.16239231
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.14849665
110Diaphragmatic weakness (HP:0009113)2.14744195
111Dysostosis multiplex (HP:0000943)2.14545036
112Glomerulosclerosis (HP:0000096)2.14372813
113Progressive macrocephaly (HP:0004481)2.13992959
114Aortic aneurysm (HP:0004942)2.13887107
115Abolished electroretinogram (ERG) (HP:0000550)2.13223340
116Abnormality of serine family amino acid metabolism (HP:0010894)2.12992083
117Abnormality of glycine metabolism (HP:0010895)2.12992083
118Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12847394
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11334052
120Acanthosis nigricans (HP:0000956)2.10305453
121Hypoplasia of the pons (HP:0012110)2.08853430
122Optic nerve hypoplasia (HP:0000609)2.08370072
123Abnormality of the corticospinal tract (HP:0002492)2.08102714
124Furrowed tongue (HP:0000221)2.07624803
125Tubulointerstitial abnormality (HP:0001969)2.07224015
126Abnormal number of erythroid precursors (HP:0012131)2.05115558
127Abnormal respiratory motile cilium physiology (HP:0012261)2.04814122
128Abnormal mitochondria in muscle tissue (HP:0008316)2.04691043
129Neoplasm of the heart (HP:0100544)2.02604624
130Severe muscular hypotonia (HP:0006829)2.02209611
131Inability to walk (HP:0002540)2.01178047
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.99325930
133Deep venous thrombosis (HP:0002625)1.99126542
134Optic disc pallor (HP:0000543)1.98844337
135Clumsiness (HP:0002312)1.98426658
136Abnormal hemoglobin (HP:0011902)1.97541865
137Male pseudohermaphroditism (HP:0000037)1.97447503
138Delayed CNS myelination (HP:0002188)1.97131374
139Abnormality of the renal collecting system (HP:0004742)1.97091348
140Renal cortical cysts (HP:0000803)1.96308425
141Aplasia involving bones of the upper limbs (HP:0009823)1.94355787
142Aplasia of the phalanges of the hand (HP:0009802)1.94355787
143Aplasia involving bones of the extremities (HP:0009825)1.94355787
144Polyuria (HP:0000103)1.94345976
145Gait imbalance (HP:0002141)1.94289491
146Broad-based gait (HP:0002136)1.93464118
147Hemiparesis (HP:0001269)1.91515293
148Oligomenorrhea (HP:0000876)1.90327647
149Congenital primary aphakia (HP:0007707)1.89410137
150Macroorchidism (HP:0000053)1.87485889
151Hypoplasia of the iris (HP:0007676)1.87200615
152Hyperventilation (HP:0002883)1.86907257
153Ectopia lentis (HP:0001083)1.86451426
154Hypoventilation (HP:0002791)1.86425975
155Hemorrhage of the eye (HP:0011885)1.86026075
156Postaxial foot polydactyly (HP:0001830)1.85163525
157Aplasia/Hypoplasia of the tibia (HP:0005772)1.83984822
1583-Methylglutaconic aciduria (HP:0003535)1.82925557
159Aortic dissection (HP:0002647)1.82798965
160Occipital encephalocele (HP:0002085)1.82565936
161Hypertriglyceridemia (HP:0002155)1.81609553
162Asplenia (HP:0001746)1.81452120
163Myopathic facies (HP:0002058)1.81347852
164Constricted visual fields (HP:0001133)1.81159224
165Ankle clonus (HP:0011448)1.79910794
166Congenital hepatic fibrosis (HP:0002612)1.78908123
167Hypoplasia of the uterus (HP:0000013)1.78638159
168Patellar aplasia (HP:0006443)1.76704538
169Renal Fanconi syndrome (HP:0001994)1.76536416
170Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75963060
171Restlessness (HP:0000711)1.75903256
172Abnormality of secondary sexual hair (HP:0009888)1.73773086
173Abnormality of the axillary hair (HP:0100134)1.73773086
174Nephrogenic diabetes insipidus (HP:0009806)1.72925535
175Genital tract atresia (HP:0001827)1.72354539
176Hepatocellular necrosis (HP:0001404)1.72110468
177Hypercholesterolemia (HP:0003124)1.71623287
178Increased connective tissue (HP:0009025)1.70708390
179Hypophosphatemia (HP:0002148)1.70586170
180Esophageal varix (HP:0002040)1.69636432
181Ketosis (HP:0001946)1.69162930
182Hepatic necrosis (HP:0002605)1.68817384
183Aplasia/Hypoplasia of the patella (HP:0006498)1.68637636
184Systemic lupus erythematosus (HP:0002725)1.68076877
185Abnormality of the labia minora (HP:0012880)1.67478406
186Muscle fiber splitting (HP:0003555)1.67313790
187Decreased circulating renin level (HP:0003351)1.66375238
188Tibial bowing (HP:0002982)1.65589444
189Anterior segment dysgenesis (HP:0007700)1.65431005
190Hyporeflexia of lower limbs (HP:0002600)1.63086216
191Aplasia of the musculature (HP:0100854)1.61278992
192Abnormality of purine metabolism (HP:0004352)1.60726596
193Nonprogressive disorder (HP:0003680)1.59091248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.12705294
2TAOK33.80716050
3ADRBK23.67214913
4LMTK23.36188860
5FRK3.25763811
6MYLK2.93391436
7TLK12.92356264
8INSRR2.87765533
9MST42.87615725
10GRK12.73413650
11ZAK2.66979583
12TRIB32.66163622
13PINK12.62701205
14SIK12.55061593
15WNK42.45037346
16BMPR1B2.42722666
17RIPK12.21895791
18WNK32.20813435
19TIE12.15681887
20ERN12.11032956
21TSSK62.11026436
22IRAK32.03054717
23MAPK151.99980407
24MAP4K21.96350057
25FER1.93518068
26OXSR11.92372528
27PRKD31.88991868
28TXK1.79575978
29LATS11.76877590
30FGFR21.75327621
31ACVR1B1.73620173
32CAMK1D1.72240491
33TTN1.70281991
34PKN21.63292357
35DYRK21.61612914
36IRAK21.60267516
37MAPK131.58595708
38CASK1.57838132
39PDGFRA1.56976699
40STK391.45743249
41ERBB21.45648139
42PAK21.43188575
43EPHB11.42901915
44NUAK11.38946853
45LRRK21.35579043
46STK38L1.35103870
47DDR21.28362404
48CAMK1G1.27913042
49TGFBR11.23455654
50CAMKK21.23390864
51TNK21.22239965
52MAP3K21.19492061
53VRK11.17998879
54ADRBK11.17739713
55RET1.14885101
56PTK21.13543089
57PAK31.10809718
58RIPK41.10254320
59STK381.10080904
60MAP2K41.08859540
61IKBKB1.06039427
62BMX1.05693548
63PNCK1.05417114
64MAPKAPK31.05198025
65VRK21.04642061
66DYRK1B1.04505724
67TRIM281.02553311
68TESK10.99448536
69MAP3K110.99390251
70EPHB20.98373022
71FGFR40.96738273
72PRKCE0.95639667
73WNK10.94110307
74MAP3K40.94071846
75EPHA30.92587373
76PTK60.90349052
77PIK3CA0.90041482
78MKNK20.88461721
79MAP2K70.87994310
80MAP3K60.83164777
81IRAK10.81656558
82PRKCH0.80892710
83SRPK10.80663750
84BRSK20.79679241
85NME10.79553094
86PRKCQ0.79109728
87NTRK20.78734167
88MARK10.76963399
89WEE10.75658285
90MAP2K20.74913835
91KIT0.74909005
92PHKG10.74762461
93PHKG20.74762461
94DMPK0.74075971
95TNIK0.72131535
96CHUK0.71246270
97INSR0.70618445
98DAPK20.69494683
99JAK20.69446769
100TEC0.69194427
101ITK0.69017818
102PAK60.68988675
103CDC42BPA0.68541968
104RPS6KA50.68130133
105PDK40.68123875
106PDK30.68123875
107EGFR0.66981701
108GRK60.64917494
109MATK0.63748040
110LATS20.63296659
111IKBKE0.62803374
112NTRK10.62691622
113EEF2K0.62176284
114CAMK2A0.61895993
115FYN0.61405259
116JAK10.60914306
117CSNK1G10.60301487
118SIK20.60262332
119DAPK30.60244836
120MAP4K10.59697820
121PKN10.58361725
122PTK2B0.58180188
123BCKDK0.57530886
124SYK0.56252824
125MAP2K60.55721600
126PDK20.55334246
127PRKCI0.55216463
128CSNK1G20.55173907
129PIK3CG0.54993230
130STK100.54123786
131MET0.52210391
132CSNK1G30.52176757
133MAPKAPK50.51514833
134GRK70.50463597
135TYRO30.50426081
136PRKCZ0.49736430
137PRKACA0.48961978
138FGFR30.47346523
139SRC0.46962260
140MAP3K120.46554709
141PLK30.46212577
142EPHA40.45819160
143SGK10.45706095
144FLT30.45614741
145IRAK40.45082910
146RPS6KA60.44934558
147MAP3K70.44291224
148CSNK1A10.43978296
149MST1R0.43842050
150PDGFRB0.42245934
151PLK20.40816769
152PDPK10.38681577
153SCYL20.37821428
154ROCK10.37684911
155PRKCA0.37357995
156NTRK30.36961030
157PDK10.36112472
158PASK0.35087886
159PRKD10.35003555
160NLK0.34717581
161CDK190.34692512
162LCK0.34519670
163MUSK0.34102853
164GSK3A0.33212314
165GRK50.33017757
166OBSCN0.32953717
167CAMK40.32898655
168MTOR0.32484611
169MAP2K10.31696536
170IGF1R0.31084972
171CAMK10.30231455
172PRKCG0.28680340
173PRKACG0.28028715
174ICK0.27516124
175CSNK1D0.26837952
176CDK50.26728168

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.39906764
2ABC transporters_Homo sapiens_hsa020103.65299844
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.38555825
4Oxidative phosphorylation_Homo sapiens_hsa001902.92981048
5Phototransduction_Homo sapiens_hsa047442.86322085
6Fatty acid degradation_Homo sapiens_hsa000712.59581574
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56735214
8Sulfur metabolism_Homo sapiens_hsa009202.52130126
9Fatty acid metabolism_Homo sapiens_hsa012122.49170975
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32802347
11PPAR signaling pathway_Homo sapiens_hsa033202.30618718
12Thyroid hormone synthesis_Homo sapiens_hsa049182.30053233
13Parkinsons disease_Homo sapiens_hsa050122.30045109
14Tryptophan metabolism_Homo sapiens_hsa003802.27332243
15Glutathione metabolism_Homo sapiens_hsa004802.26769364
16Arachidonic acid metabolism_Homo sapiens_hsa005902.24225022
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.24012212
18Protein export_Homo sapiens_hsa030602.05975764
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02203268
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96008584
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95451505
22Caffeine metabolism_Homo sapiens_hsa002321.93268863
23Glycerolipid metabolism_Homo sapiens_hsa005611.91307981
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.90615338
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88650486
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87654230
27Complement and coagulation cascades_Homo sapiens_hsa046101.75747088
28RNA polymerase_Homo sapiens_hsa030201.73065342
29Nicotine addiction_Homo sapiens_hsa050331.70436599
30Fatty acid biosynthesis_Homo sapiens_hsa000611.69772336
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.62499076
32Huntingtons disease_Homo sapiens_hsa050161.62367967
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60541854
34Alzheimers disease_Homo sapiens_hsa050101.60210402
35Arginine biosynthesis_Homo sapiens_hsa002201.58031057
36Cardiac muscle contraction_Homo sapiens_hsa042601.57464501
37Ribosome_Homo sapiens_hsa030101.55766635
38Salivary secretion_Homo sapiens_hsa049701.54296756
39Other glycan degradation_Homo sapiens_hsa005111.50966800
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.48397019
41Ether lipid metabolism_Homo sapiens_hsa005651.47317081
42Prion diseases_Homo sapiens_hsa050201.46281309
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43997315
44African trypanosomiasis_Homo sapiens_hsa051431.42373729
45Tyrosine metabolism_Homo sapiens_hsa003501.39589279
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39344583
47Homologous recombination_Homo sapiens_hsa034401.38979956
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36424116
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35599502
50One carbon pool by folate_Homo sapiens_hsa006701.35142374
51Primary immunodeficiency_Homo sapiens_hsa053401.34710229
52Basal transcription factors_Homo sapiens_hsa030221.33833842
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31165956
54Fat digestion and absorption_Homo sapiens_hsa049751.28305476
55Morphine addiction_Homo sapiens_hsa050321.27815825
56Taste transduction_Homo sapiens_hsa047421.26242729
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23305675
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22451561
59Propanoate metabolism_Homo sapiens_hsa006401.21536513
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20786365
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20608780
62Fanconi anemia pathway_Homo sapiens_hsa034601.19973640
63Phenylalanine metabolism_Homo sapiens_hsa003601.15327398
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15166532
65Asthma_Homo sapiens_hsa053101.13966922
66Olfactory transduction_Homo sapiens_hsa047401.13744684
67Vitamin B6 metabolism_Homo sapiens_hsa007501.12190221
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11513044
69Sulfur relay system_Homo sapiens_hsa041221.06222235
70Staphylococcus aureus infection_Homo sapiens_hsa051501.03343023
71Pyruvate metabolism_Homo sapiens_hsa006201.02643620
72RNA degradation_Homo sapiens_hsa030181.00214306
73Lysosome_Homo sapiens_hsa041420.99981848
74Graft-versus-host disease_Homo sapiens_hsa053320.99627174
75Vitamin digestion and absorption_Homo sapiens_hsa049770.99492463
76beta-Alanine metabolism_Homo sapiens_hsa004100.98225196
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.97638619
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96257545
79Type I diabetes mellitus_Homo sapiens_hsa049400.95896056
80Bile secretion_Homo sapiens_hsa049760.94683877
81Proteasome_Homo sapiens_hsa030500.93354326
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92459112
83Butanoate metabolism_Homo sapiens_hsa006500.91488602
84Renin secretion_Homo sapiens_hsa049240.90211688
85Carbon metabolism_Homo sapiens_hsa012000.90043341
86Protein digestion and absorption_Homo sapiens_hsa049740.89773240
87Biosynthesis of amino acids_Homo sapiens_hsa012300.89562742
88Serotonergic synapse_Homo sapiens_hsa047260.88943813
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88158161
90Starch and sucrose metabolism_Homo sapiens_hsa005000.83025817
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82944874
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82764510
93Allograft rejection_Homo sapiens_hsa053300.80625910
94Chemical carcinogenesis_Homo sapiens_hsa052040.80622895
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80534159
96Gastric acid secretion_Homo sapiens_hsa049710.79858091
97Autoimmune thyroid disease_Homo sapiens_hsa053200.73210857
98Retinol metabolism_Homo sapiens_hsa008300.73012656
99Rheumatoid arthritis_Homo sapiens_hsa053230.69448915
100Purine metabolism_Homo sapiens_hsa002300.69227889
101Peroxisome_Homo sapiens_hsa041460.67842089
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66864162
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65808245
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.65365666
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.64718811
106ECM-receptor interaction_Homo sapiens_hsa045120.63539854
107Glutamatergic synapse_Homo sapiens_hsa047240.62785804
108Arginine and proline metabolism_Homo sapiens_hsa003300.59670811
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59546588
110Mineral absorption_Homo sapiens_hsa049780.58569786
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56798433
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56071871
113Collecting duct acid secretion_Homo sapiens_hsa049660.55339466
114Type II diabetes mellitus_Homo sapiens_hsa049300.53028092
115Estrogen signaling pathway_Homo sapiens_hsa049150.52723356
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50521292
117Metabolic pathways_Homo sapiens_hsa011000.50291398
118Dorso-ventral axis formation_Homo sapiens_hsa043200.48928702
119Hedgehog signaling pathway_Homo sapiens_hsa043400.47504637
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45819981
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45234698
122Ovarian steroidogenesis_Homo sapiens_hsa049130.44871712
123Pancreatic secretion_Homo sapiens_hsa049720.44579178
124Amphetamine addiction_Homo sapiens_hsa050310.43318191
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42979431
126Histidine metabolism_Homo sapiens_hsa003400.41714511
127Basal cell carcinoma_Homo sapiens_hsa052170.40417715
128GABAergic synapse_Homo sapiens_hsa047270.39286705
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39077472
130Cocaine addiction_Homo sapiens_hsa050300.38533630
131Antigen processing and presentation_Homo sapiens_hsa046120.37429722
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36710424
133cAMP signaling pathway_Homo sapiens_hsa040240.36017104
134Circadian entrainment_Homo sapiens_hsa047130.34538453
135AMPK signaling pathway_Homo sapiens_hsa041520.34006898
136Insulin resistance_Homo sapiens_hsa049310.33751244
137Cholinergic synapse_Homo sapiens_hsa047250.33722337
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32600455
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.32401072
140Vibrio cholerae infection_Homo sapiens_hsa051100.31796128
141Pyrimidine metabolism_Homo sapiens_hsa002400.31628290
142Synaptic vesicle cycle_Homo sapiens_hsa047210.30584640
143Steroid biosynthesis_Homo sapiens_hsa001000.29321699
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.28955902
145Insulin secretion_Homo sapiens_hsa049110.28926497
146Linoleic acid metabolism_Homo sapiens_hsa005910.28383712
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28283279
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28130629
149Calcium signaling pathway_Homo sapiens_hsa040200.27888709
150Focal adhesion_Homo sapiens_hsa045100.27161812
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27000065
152Sphingolipid metabolism_Homo sapiens_hsa006000.26710306
153Glucagon signaling pathway_Homo sapiens_hsa049220.26029629
154GnRH signaling pathway_Homo sapiens_hsa049120.23427369
155Tight junction_Homo sapiens_hsa045300.22919039
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22737054
157Selenocompound metabolism_Homo sapiens_hsa004500.19682537
158Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19426607
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19300395
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.18882012
161Regulation of autophagy_Homo sapiens_hsa041400.18408544

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