WFDC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen processing and presentation (GO:0002579)9.54358004
2fusion of sperm to egg plasma membrane (GO:0007342)8.74658222
3regulation of acrosome reaction (GO:0060046)8.01649482
4seminiferous tubule development (GO:0072520)7.76272545
5regulation of antigen processing and presentation (GO:0002577)7.75959007
6plasma membrane fusion (GO:0045026)6.66345358
7regulation of clathrin-mediated endocytosis (GO:2000369)6.24309251
8complement activation, alternative pathway (GO:0006957)5.68930271
9regulation of T cell tolerance induction (GO:0002664)5.38244815
10production of molecular mediator involved in inflammatory response (GO:0002532)5.36668548
11kynurenine metabolic process (GO:0070189)4.99042303
12positive regulation of tolerance induction (GO:0002645)4.40486516
13negative regulation of receptor-mediated endocytosis (GO:0048261)4.06071670
14sperm capacitation (GO:0048240)3.95907282
15indolalkylamine catabolic process (GO:0046218)3.91282877
16tryptophan catabolic process (GO:0006569)3.91282877
17indole-containing compound catabolic process (GO:0042436)3.91282877
18regulation of tolerance induction (GO:0002643)3.88726197
19eye photoreceptor cell differentiation (GO:0001754)3.82112500
20photoreceptor cell differentiation (GO:0046530)3.82112500
21sulfur amino acid catabolic process (GO:0000098)3.81719548
22response to nitrosative stress (GO:0051409)3.77399058
23macroautophagy (GO:0016236)3.61699772
24tryptophan metabolic process (GO:0006568)3.54246227
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49189383
26regulation of chronic inflammatory response (GO:0002676)3.48321974
27alpha-linolenic acid metabolic process (GO:0036109)3.46756126
28negative regulation of interleukin-10 production (GO:0032693)3.43853833
29valine metabolic process (GO:0006573)3.41625216
30growth hormone receptor signaling pathway (GO:0060396)3.28317393
31benzene-containing compound metabolic process (GO:0042537)3.26206760
32negative regulation of endopeptidase activity (GO:0010951)3.17445109
33positive regulation of natural killer cell differentiation (GO:0032825)3.14333986
34regulation of calcium ion-dependent exocytosis (GO:0017158)3.12574684
35sexual reproduction (GO:0019953)3.11870437
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.11567002
37regulation of complement activation (GO:0030449)3.10162583
38epithelial cell differentiation involved in kidney development (GO:0035850)3.07256923
39keratan sulfate catabolic process (GO:0042340)3.05033082
40negative regulation of peptidase activity (GO:0010466)3.03284123
41positive regulation of type 2 immune response (GO:0002830)2.99842315
42regulation of protein activation cascade (GO:2000257)2.98828574
43response to misfolded protein (GO:0051788)2.96458869
44cellular sodium ion homeostasis (GO:0006883)2.85329856
45xenobiotic catabolic process (GO:0042178)2.82018445
46aromatic amino acid family catabolic process (GO:0009074)2.79422302
47cellular response to growth hormone stimulus (GO:0071378)2.77084858
48mannose metabolic process (GO:0006013)2.73298633
49phospholipid homeostasis (GO:0055091)2.73094270
50negative regulation of protein autophosphorylation (GO:0031953)2.69726386
51regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.68440206
52heterotypic cell-cell adhesion (GO:0034113)2.67267490
53hypotonic response (GO:0006971)2.64406083
54cytolysis (GO:0019835)2.62135400
55single fertilization (GO:0007338)2.61681880
56reverse cholesterol transport (GO:0043691)2.57479409
57regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.56223676
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48840562
59cellular biogenic amine catabolic process (GO:0042402)2.47221703
60amine catabolic process (GO:0009310)2.47221703
61respiratory burst (GO:0045730)2.45905647
62indolalkylamine metabolic process (GO:0006586)2.45156282
63regulation of Cdc42 GTPase activity (GO:0043088)2.44688486
64regulation of hydrogen peroxide-induced cell death (GO:1903205)2.44183615
65cysteine metabolic process (GO:0006534)2.42037005
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39711966
67negative regulation of interleukin-8 production (GO:0032717)2.30293174
68linoleic acid metabolic process (GO:0043651)2.29932748
69striated muscle atrophy (GO:0014891)2.29337948
70natural killer cell mediated immunity (GO:0002228)2.27439180
71natural killer cell mediated cytotoxicity (GO:0042267)2.27439180
72nucleoside diphosphate catabolic process (GO:0009134)2.25370738
73negative regulation of erythrocyte differentiation (GO:0045647)2.24389099
74high-density lipoprotein particle remodeling (GO:0034375)2.22706383
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.22207157
76nerve growth factor signaling pathway (GO:0038180)2.13665477
77aromatic amino acid family metabolic process (GO:0009072)2.13584791
78ethanol oxidation (GO:0006069)2.11957548
79regulation of lipoprotein metabolic process (GO:0050746)2.11012689
80cellular response to interferon-alpha (GO:0035457)2.10178129
81negative regulation of T cell apoptotic process (GO:0070233)2.07169764
82complement activation (GO:0006956)2.02676310
83myeloid cell homeostasis (GO:0002262)2.01194609
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)18.7748086
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)18.7748086
86antigen processing and presentation via MHC class Ib (GO:0002475)17.8979992
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)17.3670151
88antigen processing and presentation of endogenous antigen (GO:0019883)15.8677217
89regulation of humoral immune response (GO:0002920)1.98821583
90response to hydroperoxide (GO:0033194)1.98381787
91negative regulation of proteolysis (GO:0045861)1.98073567
92sulfur compound catabolic process (GO:0044273)1.97422643
93skeletal muscle adaptation (GO:0043501)1.96673674
94regulation of hydrogen peroxide metabolic process (GO:0010310)1.95840475
95fibroblast migration (GO:0010761)1.95724040
96negative regulation of reactive oxygen species metabolic process (GO:2000378)1.95642156
97negative regulation of endocytosis (GO:0045806)1.93735943
98GPI anchor biosynthetic process (GO:0006506)1.92994979
99T-helper 1 type immune response (GO:0042088)1.92337346
100positive regulation of cholesterol transport (GO:0032376)1.92190659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.37453819
2AR_21572438_ChIP-Seq_LNCaP_Human2.81504100
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.60220533
4IGF1R_20145208_ChIP-Seq_DFB_Human2.58311670
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.51419436
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.28539204
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17788210
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17063495
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.09291058
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08588463
11GATA1_22025678_ChIP-Seq_K562_Human11.6594530
12ZNF263_19887448_ChIP-Seq_K562_Human1.98916294
13LXR_22158963_ChIP-Seq_LIVER_Mouse1.98346862
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88728311
15RXR_22158963_ChIP-Seq_LIVER_Mouse1.77392982
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73499126
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65910900
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64651298
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60807351
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60579019
21VDR_24787735_ChIP-Seq_THP-1_Human1.53069180
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47191343
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46425041
24CLOCK_20551151_ChIP-Seq_293T_Human1.45408804
25SOX2_20726797_ChIP-Seq_SW620_Human1.40500517
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39433210
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.39327697
28MYC_19915707_ChIP-ChIP_AK7_Human1.34664444
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.27811094
30EGR1_19032775_ChIP-ChIP_M12_Human1.27697562
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27128614
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25370100
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22608307
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22430070
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20044348
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19147484
37STAT1_17558387_ChIP-Seq_HELA_Human1.18417982
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15338333
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13158285
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11668898
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10802644
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.08542397
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07960202
44CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07643655
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.07235195
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06527674
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06034034
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.01733057
49SMAD4_21741376_ChIP-Seq_HESCs_Human0.99572018
50ELF1_20517297_ChIP-Seq_JURKAT_Human0.99517025
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98512700
52ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96849115
53SMRT_27268052_Chip-Seq_Bcells_Human0.95298567
54ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93634057
55CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93017702
56EP300_21415370_ChIP-Seq_HL-1_Mouse0.92835276
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92315772
58ZNF274_21170338_ChIP-Seq_K562_Hela0.92251962
59AHR_22903824_ChIP-Seq_MCF-7_Human0.90818915
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90355294
61LXR_22292898_ChIP-Seq_THP-1_Human0.89958362
62STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86882095
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86839766
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85365901
65TP63_23658742_ChIP-Seq_EP156T_Human0.85035939
66FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84630520
67IRF8_21731497_ChIP-ChIP_J774_Mouse0.84532243
68PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83992424
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83533790
70FOXO3_23340844_ChIP-Seq_DLD1_Human0.83425652
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83237895
72TAF2_19829295_ChIP-Seq_ESCs_Human0.82690115
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80807496
74TBX20_22328084_ChIP-Seq_HEART_Mouse0.80430691
75TBX20_22080862_ChIP-Seq_HEART_Mouse0.80430691
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80351961
77CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80071274
78FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79287458
79RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78628387
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78224856
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78146203
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77866452
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76868618
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76809539
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76200458
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76106559
87IRF8_27001747_Chip-Seq_BMDM_Mouse0.75406634
88OCT4_20526341_ChIP-Seq_ESCs_Human0.75115100
89KDM2B_26808549_Chip-Seq_REH_Human0.73490325
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73417454
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73417454
92SMAD4_21799915_ChIP-Seq_A2780_Human0.73391335
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72735445
94SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72563333
95GATA2_19941826_ChIP-Seq_K562_Human0.72262747
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71609948
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71081400
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.70507286
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69369961
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.69238359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.45996191
2MP0010234_abnormal_vibrissa_follicle4.35152464
3MP0003300_gastrointestinal_ulcer4.20475539
4MP0002139_abnormal_hepatobiliary_system3.54147369
5MP0003195_calcinosis3.07732885
6MP0005410_abnormal_fertilization2.71842699
7MP0002254_reproductive_system_inflammat2.66919546
8MP0003303_peritoneal_inflammation2.54540463
9MP0005275_abnormal_skin_tensile2.41825827
10MP0003436_decreased_susceptibility_to2.35619305
11MP0003172_abnormal_lysosome_physiology2.28579003
12MP0005377_hearing/vestibular/ear_phenot2.27583302
13MP0003878_abnormal_ear_physiology2.27583302
14MP0008438_abnormal_cutaneous_collagen2.24253410
15MP0003566_abnormal_cell_adhesion2.15706530
16MP0002138_abnormal_hepatobiliary_system2.14309997
17MP0003045_fibrosis2.09579081
18MP0001835_abnormal_antigen_presentation1.96655160
19MP0009763_increased_sensitivity_to1.89249155
20MP0001533_abnormal_skeleton_physiology1.83239293
21MP0000685_abnormal_immune_system1.69228564
22MP0010329_abnormal_lipoprotein_level1.63900868
23MP0009384_cardiac_valve_regurgitation1.62030634
24MP0003075_altered_response_to1.60489893
25MP0010678_abnormal_skin_adnexa1.53488202
26MP0000569_abnormal_digit_pigmentation1.51708467
27MP0002166_altered_tumor_susceptibility1.51282165
28MP0003091_abnormal_cell_migration1.50924031
29MP0004043_abnormal_pH_regulation1.49782775
30MP0003705_abnormal_hypodermis_morpholog1.48663688
31MP0002168_other_aberrant_phenotype1.47541886
32MP0003656_abnormal_erythrocyte_physiolo1.46915203
33MP0002148_abnormal_hypersensitivity_rea1.39940729
34MP0004947_skin_inflammation1.38649376
35MP0002282_abnormal_trachea_morphology1.38361698
36MP0005636_abnormal_mineral_homeostasis1.36676462
37MP0009643_abnormal_urine_homeostasis1.36416686
38MP0002876_abnormal_thyroid_physiology1.26870201
39MP0002006_tumorigenesis1.25614287
40MP0004858_abnormal_nervous_system1.23559160
41MP0004019_abnormal_vitamin_homeostasis1.22167432
42MP0009785_altered_susceptibility_to1.20270490
43MP0003191_abnormal_cellular_cholesterol1.19299918
44MP0008995_early_reproductive_senescence1.16900503
45MP0005365_abnormal_bile_salt1.16564565
46MP0001765_abnormal_ion_homeostasis1.16231060
47MP0010386_abnormal_urinary_bladder1.15897153
48MP0002896_abnormal_bone_mineralization1.14295940
49MP0005584_abnormal_enzyme/coenzyme_acti1.13025033
50MP0004272_abnormal_basement_membrane1.12102829
51MP0005085_abnormal_gallbladder_physiolo1.11000232
52MP0002933_joint_inflammation1.09959467
53MP0002009_preneoplasia1.09738441
54MP0000003_abnormal_adipose_tissue1.08186629
55MP0009765_abnormal_xenobiotic_induced1.01832761
56MP0001845_abnormal_inflammatory_respons1.01252971
57MP0003690_abnormal_glial_cell1.00468228
58MP0005310_abnormal_salivary_gland1.00309490
59MP0005464_abnormal_platelet_physiology0.98896022
60MP0001853_heart_inflammation0.98691607
61MP0002118_abnormal_lipid_homeostasis0.97738754
62MP0003448_altered_tumor_morphology0.97175793
63MP0001348_abnormal_lacrimal_gland0.96473162
64MP0005375_adipose_tissue_phenotype0.93169312
65MP0002419_abnormal_innate_immunity0.92771673
66MP0000343_altered_response_to0.92324536
67MP0001666_abnormal_nutrient_absorption0.92049796
68MP0001881_abnormal_mammary_gland0.91929252
69MP0005408_hypopigmentation0.91540775
70MP0002693_abnormal_pancreas_physiology0.90480668
71MP0000604_amyloidosis0.90358540
72MP0010352_gastrointestinal_tract_polyps0.89957801
73MP0003252_abnormal_bile_duct0.89918556
74MP0005503_abnormal_tendon_morphology0.88717085
75MP0001849_ear_inflammation0.87052683
76MP0005166_decreased_susceptibility_to0.85834637
77MP0006082_CNS_inflammation0.85700025
78MP0002136_abnormal_kidney_physiology0.85285611
79MP0008004_abnormal_stomach_pH0.83816785
80MP0004264_abnormal_extraembryonic_tissu0.83403312
81MP0002295_abnormal_pulmonary_circulatio0.82919018
82MP0003183_abnormal_peptide_metabolism0.82708453
83MP0005025_abnormal_response_to0.82648970
84MP0003329_amyloid_beta_deposits0.82579394
85MP0005360_urolithiasis0.82317088
86MP0002998_abnormal_bone_remodeling0.82110193
87MP0000249_abnormal_blood_vessel0.79947415
88MP0003698_abnormal_male_reproductive0.79230183
89MP0002796_impaired_skin_barrier0.78398995
90MP0005390_skeleton_phenotype0.77983416
91MP0003866_abnormal_defecation0.77572677
92MP0000609_abnormal_liver_physiology0.77547762
93MP0005666_abnormal_adipose_tissue0.75893478
94MP0004130_abnormal_muscle_cell0.75520324
95MP0003186_abnormal_redox_activity0.74408916
96MP0008469_abnormal_protein_level0.74320746
97MP0009780_abnormal_chondrocyte_physiolo0.74125077
98MP0005319_abnormal_enzyme/_coenzyme0.71884068
99MP0005332_abnormal_amino_acid0.70768697
100MP0004134_abnormal_chest_morphology0.70138103

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)5.88434642
2Abnormality of complement system (HP:0005339)5.03541630
3Recurrent gram-negative bacterial infections (HP:0005420)5.00553964
4Cervical subluxation (HP:0003308)4.75170869
5Myocardial infarction (HP:0001658)4.43881417
6Facial shape deformation (HP:0011334)4.27067280
7Potter facies (HP:0002009)4.27067280
8Choroideremia (HP:0001139)4.26772270
9Vacuolated lymphocytes (HP:0001922)4.21932774
10Vascular calcification (HP:0004934)3.92239414
11Hand muscle atrophy (HP:0009130)3.89315160
12Ulnar deviation of the wrist (HP:0003049)3.88258846
13Abnormality of the fovea (HP:0000493)3.75206174
14Abnormal rod and cone electroretinograms (HP:0008323)3.74146806
15Cardiovascular calcification (HP:0011915)3.69290201
16Central scotoma (HP:0000603)3.68519377
1711 pairs of ribs (HP:0000878)3.64252710
18Metaphyseal cupping (HP:0003021)3.55513409
19Proximal tubulopathy (HP:0000114)3.51980526
20Cone-rod dystrophy (HP:0000548)3.50280358
21Stridor (HP:0010307)3.42998179
22Loss of speech (HP:0002371)3.31392529
23Abnormality of macular pigmentation (HP:0008002)3.26456242
24Epiphyseal dysplasia (HP:0002656)3.19908884
25Upper limb amyotrophy (HP:0009129)3.18387083
26Distal upper limb amyotrophy (HP:0007149)3.18387083
27Hypophosphatemic rickets (HP:0004912)3.16873268
28Hypopigmentation of the fundus (HP:0007894)3.10265284
29Diaphragmatic weakness (HP:0009113)2.99626728
30Urinary glycosaminoglycan excretion (HP:0003541)2.96549764
31Mucopolysacchariduria (HP:0008155)2.96549764
32Hypoplasia of the odontoid process (HP:0003311)2.95797344
33Disproportionate short-trunk short stature (HP:0003521)2.93530097
34Bony spicule pigmentary retinopathy (HP:0007737)2.88156561
35Intention tremor (HP:0002080)2.85469786
36Tubulointerstitial fibrosis (HP:0005576)2.76539800
37Dyschromatopsia (HP:0007641)2.74616280
38Osteomalacia (HP:0002749)2.69766498
39Spontaneous abortion (HP:0005268)2.69261317
40Progressive visual loss (HP:0000529)2.66079544
41Abnormality of polysaccharide metabolism (HP:0011012)2.59421658
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59421658
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59421658
44Gastrointestinal infarctions (HP:0005244)2.58522480
45Agitation (HP:0000713)2.58178781
46Action tremor (HP:0002345)2.57649612
47Mutism (HP:0002300)2.52457395
48Macular degeneration (HP:0000608)2.51911338
49Muscle fiber splitting (HP:0003555)2.50801906
50Abnormality of the odontoid process (HP:0003310)2.49310492
51Flat acetabular roof (HP:0003180)2.42066707
52Osteolytic defects of the hand bones (HP:0009699)2.39567058
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.39567058
54Delayed epiphyseal ossification (HP:0002663)2.31265984
55Facial diplegia (HP:0001349)2.28787888
56Ectopia lentis (HP:0001083)2.27161033
57Missing ribs (HP:0000921)2.25755167
58Abolished electroretinogram (ERG) (HP:0000550)2.23568380
59Hyperphosphatemia (HP:0002905)2.20578635
60Abnormality of the calcaneus (HP:0008364)2.19634905
61Infantile muscular hypotonia (HP:0008947)2.19353008
62Duplicated collecting system (HP:0000081)2.14383956
63Thin bony cortex (HP:0002753)2.10628868
64Restlessness (HP:0000711)2.08260080
65Eczematoid dermatitis (HP:0000976)2.07606131
66Dysostosis multiplex (HP:0000943)2.05056694
67Ovoid vertebral bodies (HP:0003300)2.03463934
68Clumsiness (HP:0002312)2.01745490
69Esophageal varix (HP:0002040)2.01461035
70Right ventricular cardiomyopathy (HP:0011663)2.00891584
71Abnormality of macrophages (HP:0004311)1.98649576
72Decreased central vision (HP:0007663)1.94802811
73Impulsivity (HP:0100710)1.93983611
74Rickets (HP:0002748)1.88275330
75Focal segmental glomerulosclerosis (HP:0000097)1.87721081
76Enlarged epiphyses (HP:0010580)1.87602074
77Beaking of vertebral bodies (HP:0004568)1.86810720
78Bicornuate uterus (HP:0000813)1.84257035
79Abnormality of the lumbar spine (HP:0100712)1.82794074
80Gingivitis (HP:0000230)1.82482659
81Proximal amyotrophy (HP:0007126)1.81543616
82Aneurysm (HP:0002617)1.81187420
83Scotoma (HP:0000575)1.80386342
84Glomerulosclerosis (HP:0000096)1.78910375
85Neurofibrillary tangles (HP:0002185)1.78397381
86Increased connective tissue (HP:0009025)1.76701640
87Abnormality of the vocal cords (HP:0008777)1.76681690
88Aplasia of the musculature (HP:0100854)1.76113582
89Deep venous thrombosis (HP:0002625)1.75664612
90Thin ribs (HP:0000883)1.74107112
91Metaphyseal irregularity (HP:0003025)1.73892818
92Vitreoretinal degeneration (HP:0000655)1.73209079
93Tetraparesis (HP:0002273)1.72227671
94Increased IgE level (HP:0003212)1.72186755
95Scanning speech (HP:0002168)1.71555710
96Interstitial pulmonary disease (HP:0006530)1.70456940
97Aortic aneurysm (HP:0004942)1.69668678
98Gingival bleeding (HP:0000225)1.68984402
99Hypercortisolism (HP:0001578)1.68423695
100Barrel-shaped chest (HP:0001552)1.68175031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.72053690
2EPHA34.00649303
3MST43.71627954
4EPHB13.57775987
5PBK2.92611295
6MAP3K92.76772905
7AKT32.57369412
8SIK12.57032041
9TAOK32.56286834
10FGFR42.46263292
11FER2.23935465
12ARAF2.23530585
13MAP3K142.23487913
14ERN12.15588613
15LATS11.98452464
16WNK41.97752687
17MYLK1.93141489
18FRK1.84950087
19KSR21.55639359
20WNK31.55280794
21JAK11.53981690
22ERBB31.53225647
23INSRR1.46608796
24LMTK21.46552522
25DDR21.42064585
26IRAK11.41565258
27MAP3K31.30272529
28TRIB31.28397503
29NEK91.20805809
30JAK31.15870773
31MATK1.13987226
32PAK31.06950990
33TTN1.05621610
34FGFR31.02070050
35TYK21.00773309
36TNK21.00597624
37JAK20.97946263
38PKN20.95630897
39ERBB20.95304509
40IRAK30.94490635
41FGFR20.92540707
42LRRK20.90855890
43CAMK1D0.90513389
44RET0.86310427
45MAP3K10.85444597
46PTK60.82985000
47STK390.81993364
48RIPK40.81718816
49TBK10.79521774
50MAP2K10.75880329
51MAP3K70.75623350
52MOS0.74999747
53WNK10.74896319
54DAPK20.73363728
55HIPK20.72009875
56PTK20.67177747
57PDGFRA0.66896569
58PTK2B0.66016231
59PAK20.65536607
60EGFR0.63882842
61MAP3K20.62951154
62RPS6KA40.61272577
63ALK0.60474350
64DYRK1B0.56818111
65MAPKAPK30.56428405
66TYRO30.55908661
67NTRK10.55420563
68STK40.51884848
69TRPM70.50208468
70PRKD30.50072178
71RIPK10.49364642
72PIK3CG0.49127068
73KSR10.47154472
74SRC0.46869393
75RAF10.46566589
76DAPK30.44836151
77MAP2K40.43237756
78FYN0.40914029
79BMPR20.40681268
80INSR0.39830261
81STK30.38946874
82CAMK1G0.38415235
83PRKCQ0.37605587
84IRAK40.36328190
85NLK0.35629593
86HCK0.34235863
87SGK10.31659829
88MAP2K30.31594638
89MAPKAPK50.30841424
90SYK0.30765995
91BMX0.28110588
92CHUK0.26268394
93GSK3A0.26093292
94LCK0.25960351
95EEF2K0.23723407
96MTOR0.23088195
97PDPK10.22374165
98CDK190.21195228
99TESK10.20951019
100MAPK120.20594127

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.86003287
2ABC transporters_Homo sapiens_hsa020103.60476942
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.52128381
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83862022
5Sulfur metabolism_Homo sapiens_hsa009202.65827586
6Fatty acid degradation_Homo sapiens_hsa000712.39691626
7Fatty acid metabolism_Homo sapiens_hsa012122.29761443
8African trypanosomiasis_Homo sapiens_hsa051432.28103047
9Glutathione metabolism_Homo sapiens_hsa004802.13054325
10Tryptophan metabolism_Homo sapiens_hsa003802.09015170
11Arachidonic acid metabolism_Homo sapiens_hsa005901.93589365
12Complement and coagulation cascades_Homo sapiens_hsa046101.86477637
13PPAR signaling pathway_Homo sapiens_hsa033201.78555475
14Other glycan degradation_Homo sapiens_hsa005111.77676857
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.72673560
16Thyroid hormone synthesis_Homo sapiens_hsa049181.68397209
17Prion diseases_Homo sapiens_hsa050201.56133944
18Lysosome_Homo sapiens_hsa041421.55626127
19Arginine biosynthesis_Homo sapiens_hsa002201.48742891
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44806776
21Glycerolipid metabolism_Homo sapiens_hsa005611.42016848
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.41993940
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37736479
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36538489
25Protein digestion and absorption_Homo sapiens_hsa049741.32502033
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23588048
27Staphylococcus aureus infection_Homo sapiens_hsa051501.22968325
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22185170
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19368727
30Vitamin digestion and absorption_Homo sapiens_hsa049771.18672090
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17349891
32Fatty acid biosynthesis_Homo sapiens_hsa000611.05649893
33Chemical carcinogenesis_Homo sapiens_hsa052040.97705712
34Salivary secretion_Homo sapiens_hsa049700.97101728
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96829579
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96150464
37ECM-receptor interaction_Homo sapiens_hsa045120.95185093
38Fatty acid elongation_Homo sapiens_hsa000620.94398487
39Fat digestion and absorption_Homo sapiens_hsa049750.91848404
40Tyrosine metabolism_Homo sapiens_hsa003500.91578398
41Leishmaniasis_Homo sapiens_hsa051400.88880816
42Pertussis_Homo sapiens_hsa051330.86995522
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86012888
44Graft-versus-host disease_Homo sapiens_hsa053320.85376781
45Propanoate metabolism_Homo sapiens_hsa006400.83905694
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82475484
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81564096
48Starch and sucrose metabolism_Homo sapiens_hsa005000.78304917
49Phenylalanine metabolism_Homo sapiens_hsa003600.72554191
50Toxoplasmosis_Homo sapiens_hsa051450.70316676
51Peroxisome_Homo sapiens_hsa041460.68144059
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65711436
53Influenza A_Homo sapiens_hsa051640.64272433
54Platelet activation_Homo sapiens_hsa046110.62508367
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59918326
56TNF signaling pathway_Homo sapiens_hsa046680.59661307
57Pyruvate metabolism_Homo sapiens_hsa006200.58706020
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58169310
59Legionellosis_Homo sapiens_hsa051340.57944932
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.57880509
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54435890
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54413082
63Amoebiasis_Homo sapiens_hsa051460.53050658
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52778903
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.51584031
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51168260
67beta-Alanine metabolism_Homo sapiens_hsa004100.49879411
68Mineral absorption_Homo sapiens_hsa049780.49386821
69Carbon metabolism_Homo sapiens_hsa012000.49324707
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49023959
71Antigen processing and presentation_Homo sapiens_hsa046120.48018852
72Butanoate metabolism_Homo sapiens_hsa006500.47969365
73Bile secretion_Homo sapiens_hsa049760.42284564
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41601086
75Prolactin signaling pathway_Homo sapiens_hsa049170.39797804
76Dorso-ventral axis formation_Homo sapiens_hsa043200.39517553
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.39064853
78Focal adhesion_Homo sapiens_hsa045100.38531528
79Collecting duct acid secretion_Homo sapiens_hsa049660.37402648
80Renin secretion_Homo sapiens_hsa049240.37169890
81Steroid biosynthesis_Homo sapiens_hsa001000.35969626
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35490880
83Ovarian steroidogenesis_Homo sapiens_hsa049130.34334712
84Measles_Homo sapiens_hsa051620.34186485
85Osteoclast differentiation_Homo sapiens_hsa043800.33017313
86Type II diabetes mellitus_Homo sapiens_hsa049300.32783657
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32541067
88Gastric acid secretion_Homo sapiens_hsa049710.32159018
89Arginine and proline metabolism_Homo sapiens_hsa003300.31784797
90Estrogen signaling pathway_Homo sapiens_hsa049150.31216049
91Salmonella infection_Homo sapiens_hsa051320.30619450
92Insulin resistance_Homo sapiens_hsa049310.30168472
93Renin-angiotensin system_Homo sapiens_hsa046140.29540717
94Phagosome_Homo sapiens_hsa041450.28965354
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28790838
96Vibrio cholerae infection_Homo sapiens_hsa051100.28423509
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28013832
98Hepatitis C_Homo sapiens_hsa051600.27742243
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27704302
100Pancreatic secretion_Homo sapiens_hsa049720.26773921

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