WFIKKN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.74566437
2antigen processing and presentation of endogenous antigen (GO:0019883)7.28006256
3regulation of phospholipase A2 activity (GO:0032429)6.65084938
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.57094987
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.16284905
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.16284905
7peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.14639453
8virion attachment to host cell (GO:0019062)6.11984739
9adhesion of symbiont to host cell (GO:0044650)6.11984739
10coenzyme catabolic process (GO:0009109)5.80513686
11mRNA cleavage (GO:0006379)5.67673021
12positive regulation of natural killer cell differentiation (GO:0032825)5.49731830
13activation of protein kinase B activity (GO:0032148)5.48590834
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.37758255
15mesenchymal-epithelial cell signaling (GO:0060638)5.23318221
16regulation of secondary heart field cardioblast proliferation (GO:0003266)5.03809051
17regulation of cardioblast proliferation (GO:0003264)5.03809051
18adhesion of symbiont to host (GO:0044406)5.00418389
19regulation of autophagic vacuole assembly (GO:2000785)4.99735453
20paraxial mesoderm development (GO:0048339)4.98065260
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.86987350
22negative regulation of defense response to virus (GO:0050687)4.76899330
23cGMP-mediated signaling (GO:0019934)4.75441903
24eosinophil chemotaxis (GO:0048245)4.74185747
25negative regulation of striated muscle cell apoptotic process (GO:0010664)4.65878441
26regulation of somitogenesis (GO:0014807)4.63566069
27cellular response to interferon-alpha (GO:0035457)4.38700495
28diacylglycerol metabolic process (GO:0046339)4.29391852
29eosinophil migration (GO:0072677)4.23131521
30androgen biosynthetic process (GO:0006702)4.16440909
31thyroid gland development (GO:0030878)4.15851731
32ganglion development (GO:0061548)4.12554388
33thymic T cell selection (GO:0045061)4.11534882
34mesenchymal cell differentiation involved in renal system development (GO:2001012)4.10696171
35mesenchymal cell differentiation involved in kidney development (GO:0072161)4.10696171
36relaxation of smooth muscle (GO:0044557)4.10112718
37protein localization to cell surface (GO:0034394)4.04495523
38regulation of protein kinase C signaling (GO:0090036)3.99422118
39regulation of vacuole organization (GO:0044088)3.95589167
40positive regulation of catecholamine secretion (GO:0033605)3.95191169
41otic vesicle formation (GO:0030916)3.94279054
42positive regulation of protein kinase C signaling (GO:0090037)3.93982770
43barbed-end actin filament capping (GO:0051016)3.93139159
44desmosome organization (GO:0002934)3.91188874
45lateral sprouting from an epithelium (GO:0060601)3.86906672
46muscle cell fate commitment (GO:0042693)3.85979621
47regulation of natural killer cell differentiation (GO:0032823)3.85202388
48axon extension involved in axon guidance (GO:0048846)3.78267690
49neuron projection extension involved in neuron projection guidance (GO:1902284)3.78267690
50regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.76354656
51cellular response to vitamin (GO:0071295)3.75851647
52motile cilium assembly (GO:0044458)3.74608469
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.74040726
54positive regulation of antigen processing and presentation (GO:0002579)3.73502957
55negative regulation of smooth muscle cell proliferation (GO:0048662)3.64960848
56positive thymic T cell selection (GO:0045059)3.64104544
57regulation of transforming growth factor beta2 production (GO:0032909)3.61686216
58negative T cell selection (GO:0043383)3.60370396
59thymus development (GO:0048538)3.59862351
60response to interferon-alpha (GO:0035455)3.57714870
61T cell selection (GO:0045058)3.54324519
62response to type I interferon (GO:0034340)3.53162422
63type I interferon signaling pathway (GO:0060337)3.51990622
64cellular response to type I interferon (GO:0071357)3.51990622
65positive regulation of myoblast differentiation (GO:0045663)3.51788029
66negative regulation of inclusion body assembly (GO:0090084)3.49912000
67glucocorticoid biosynthetic process (GO:0006704)3.47981556
68negative thymic T cell selection (GO:0045060)3.47540817
69sulfation (GO:0051923)3.44480453
70regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.40887406
71cellular response to zinc ion (GO:0071294)3.39418424
72cell differentiation involved in metanephros development (GO:0072202)3.38515585
73histone H3-K36 demethylation (GO:0070544)3.35920516
74positive T cell selection (GO:0043368)3.35654785
75regulation of cardiac muscle cell apoptotic process (GO:0010665)3.32259411
76response to muscle activity (GO:0014850)3.29259751
77middle ear morphogenesis (GO:0042474)3.26075631
78cranial nerve morphogenesis (GO:0021602)3.25692011
79myelination in peripheral nervous system (GO:0022011)3.24337268
80peripheral nervous system axon ensheathment (GO:0032292)3.24337268
81cell-cell junction maintenance (GO:0045217)3.23627193
82regulation of phosphoprotein phosphatase activity (GO:0043666)3.21843914
83regulation of ARF GTPase activity (GO:0032312)3.20170537
84negative regulation of leukocyte apoptotic process (GO:2000107)3.20147518
85CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.15522464
86presynaptic membrane assembly (GO:0097105)3.15243402
87collecting duct development (GO:0072044)3.12958354
88multicellular organism reproduction (GO:0032504)3.12409356
89epithelial cell fate commitment (GO:0072148)3.07319758
90interferon-gamma-mediated signaling pathway (GO:0060333)3.07269799
91neuromuscular synaptic transmission (GO:0007274)3.05434897
92regulation of antigen processing and presentation (GO:0002577)3.04117056
93regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.01946521
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00909901
95negative regulation of T cell apoptotic process (GO:0070233)2.99301504
96urinary tract smooth muscle contraction (GO:0014848)2.98515417
97negative regulation of osteoblast proliferation (GO:0033689)2.97848669
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.97664086
99cell migration involved in heart development (GO:0060973)2.96572152
100peroxisome fission (GO:0016559)2.96284489
101mesonephros development (GO:0001823)2.95783532
102embryonic camera-type eye development (GO:0031076)2.95590185
103cell-substrate junction assembly (GO:0007044)2.94870004
104positive regulation of embryonic development (GO:0040019)2.94831875
105positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.94120581
106regulation of striated muscle cell apoptotic process (GO:0010662)2.94059495
107oligosaccharide biosynthetic process (GO:0009312)2.93971941
108regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.93146256
109postsynaptic membrane organization (GO:0001941)2.93090177
110tongue development (GO:0043586)2.92537621
111genitalia morphogenesis (GO:0035112)2.91418022
112embryonic skeletal system morphogenesis (GO:0048704)2.91253374
113T cell lineage commitment (GO:0002360)2.90045534
114positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.89851622
115myofibril assembly (GO:0030239)2.89025572
116negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.88069820
117NIK/NF-kappaB signaling (GO:0038061)2.84957031
118aorta morphogenesis (GO:0035909)2.84437339
119CD4-positive, alpha-beta T cell activation (GO:0035710)2.84359739
120branching involved in labyrinthine layer morphogenesis (GO:0060670)2.84302446
121adult heart development (GO:0007512)2.82879639
122negative regulation of fibroblast apoptotic process (GO:2000270)2.81106689
123bone morphogenesis (GO:0060349)2.80302904
124myoblast migration (GO:0051451)2.79092488
125cofactor catabolic process (GO:0051187)2.78952948
126vitamin A metabolic process (GO:0006776)2.77949010
127axonemal dynein complex assembly (GO:0070286)2.77482381
128regulation of glomerular filtration (GO:0003093)2.75278857
129cellular zinc ion homeostasis (GO:0006882)2.75026687
130regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74001893
131establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.73047363
132regulation of chemokine-mediated signaling pathway (GO:0070099)2.72562980
133negative regulation of response to biotic stimulus (GO:0002832)2.72260721
134positive regulation of response to cytokine stimulus (GO:0060760)2.71809780
135cGMP biosynthetic process (GO:0006182)2.70192970
136detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.69501085
137JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.69380210
138positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.68261595
139C21-steroid hormone biosynthetic process (GO:0006700)2.68213735
140antigen processing and presentation via MHC class Ib (GO:0002475)2.68022377
141outer ear morphogenesis (GO:0042473)2.65283132
142relaxation of muscle (GO:0090075)2.64453227
143negative regulation of activin receptor signaling pathway (GO:0032926)2.64214477
144ventricular cardiac muscle cell action potential (GO:0086005)2.63973426
145presynaptic membrane organization (GO:0097090)2.63604539
146type B pancreatic cell development (GO:0003323)2.63580496
147heterochromatin organization (GO:0070828)2.63334395
148muscle filament sliding (GO:0030049)2.62893877
149actin-myosin filament sliding (GO:0033275)2.62893877
150regulation of cellular extravasation (GO:0002691)2.62164973
151regulation of keratinocyte proliferation (GO:0010837)2.62054231
152striated muscle hypertrophy (GO:0014897)2.61944002
153lung epithelium development (GO:0060428)2.60267857
154cell junction maintenance (GO:0034331)2.60252786
155notochord development (GO:0030903)2.59620973
156potassium ion export (GO:0071435)2.59458239
157limb bud formation (GO:0060174)2.58577636
158embryonic cranial skeleton morphogenesis (GO:0048701)2.57775887
159negative regulation of muscle cell apoptotic process (GO:0010656)2.57638726
160negative regulation of macroautophagy (GO:0016242)2.57329232
161muscle contraction (GO:0006936)2.56899595
162cell proliferation involved in metanephros development (GO:0072203)2.56516267
163locomotory exploration behavior (GO:0035641)2.56394501
164actin-mediated cell contraction (GO:0070252)2.56092086
165gland morphogenesis (GO:0022612)2.55100471
166smooth muscle cell differentiation (GO:0051145)2.54776525
167muscle system process (GO:0003012)2.54639083
168mesenchymal cell differentiation (GO:0048762)2.54269691
169alpha-beta T cell differentiation (GO:0046632)2.54022038
170regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.53607110
171positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.53419039
172cardiac muscle adaptation (GO:0014887)2.52028172
173cardiac muscle hypertrophy in response to stress (GO:0014898)2.52028172
174muscle hypertrophy in response to stress (GO:0003299)2.52028172
175receptor recycling (GO:0001881)2.51683850
176ADP metabolic process (GO:0046031)2.50873029
177metanephric mesenchyme development (GO:0072075)2.50640925
178bone resorption (GO:0045453)2.49642972
179epithelial cilium movement (GO:0003351)2.49348274
180pharyngeal system development (GO:0060037)2.49119211
181regulation of hair follicle development (GO:0051797)2.47581274
182chaperone mediated protein folding requiring cofactor (GO:0051085)2.46916130
183positive regulation of gamma-delta T cell activation (GO:0046645)2.46842460
184pyrimidine nucleobase catabolic process (GO:0006208)2.46838568
185lymphocyte chemotaxis (GO:0048247)2.46711123
186chronic inflammatory response (GO:0002544)2.46303401
187substrate-independent telencephalic tangential migration (GO:0021826)2.46141131
188substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.46141131
189regulation of myoblast differentiation (GO:0045661)2.45969051
190regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45820528
191positive regulation of natural killer cell activation (GO:0032816)2.45638588
192organ growth (GO:0035265)2.45341174
193negative regulation of lymphocyte apoptotic process (GO:0070229)2.44992077
194Notch receptor processing (GO:0007220)2.43383015
195cell proliferation involved in kidney development (GO:0072111)2.42936574
196regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.39713706
197regulation of monocyte differentiation (GO:0045655)2.36266903
198regulation of RIG-I signaling pathway (GO:0039535)2.33723513
199cellular response to vitamin D (GO:0071305)2.32169868
200regulation of heart rate by cardiac conduction (GO:0086091)2.31084016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.72036215
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.71554949
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse5.08726322
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.87352623
5GBX2_23144817_ChIP-Seq_PC3_Human4.23007447
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68496031
7EZH2_22144423_ChIP-Seq_EOC_Human3.61900003
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35306586
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.31437638
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.72232772
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70916567
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64400146
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55949518
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.54641805
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.12563578
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.10261191
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09410615
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.07457489
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94827981
20SOX9_24532713_ChIP-Seq_HFSC_Mouse1.85005028
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.84635222
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82604260
23AR_21572438_ChIP-Seq_LNCaP_Human1.77133812
24RUNX_20019798_ChIP-Seq_JUKART_Human1.76725550
25VDR_22108803_ChIP-Seq_LS180_Human1.74551394
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73502810
27IGF1R_20145208_ChIP-Seq_DFB_Human1.72914151
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.72641480
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72216147
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.70920345
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69781524
32RXR_22108803_ChIP-Seq_LS180_Human1.67739179
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67011746
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67011746
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66988527
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66988527
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.66946412
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.66809093
39* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63905274
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63214291
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.61685739
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59592414
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56900934
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.56695236
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55769854
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.55026650
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54029706
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53168673
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49532175
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49434423
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48101909
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.44965414
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44578835
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.43674656
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43623881
56* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42678928
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35871523
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34884020
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34702520
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34644808
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.33915845
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33818244
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33626941
64ER_23166858_ChIP-Seq_MCF-7_Human1.31598334
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28854431
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26899622
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.26170417
68AHR_22903824_ChIP-Seq_MCF-7_Human1.25572973
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25313556
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24211442
71CJUN_26792858_Chip-Seq_BT549_Human1.24117728
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.23960187
73TP53_18474530_ChIP-ChIP_U2OS_Human1.23713188
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23017591
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.22674621
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22605608
77SMAD4_21799915_ChIP-Seq_A2780_Human1.21313906
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.21284479
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20139752
80CLOCK_20551151_ChIP-Seq_293T_Human1.19573318
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19076826
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18922709
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17163284
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16378918
85* P300_19829295_ChIP-Seq_ESCs_Human1.13408098
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13156472
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13064614
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13047696
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11670376
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11598143
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10758288
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10523475
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09463494
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06944077
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06376912
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.04800129
97CTCF_27219007_Chip-Seq_Bcells_Human1.04477296
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04223097
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02868078
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.02639766
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02416885
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02342265
103* TBX20_22080862_ChIP-Seq_HEART_Mouse1.02153890
104* TBX20_22328084_ChIP-Seq_HEART_Mouse1.02153890
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01605369
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01605369
107SOX2_20726797_ChIP-Seq_SW620_Human1.01308901
108TP53_16413492_ChIP-PET_HCT116_Human1.00481269
109VDR_24787735_ChIP-Seq_THP-1_Human0.97769689
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97458424
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.97438864
112* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97123714
113RUNX1_27514584_Chip-Seq_MCF-7_Human0.96817100
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96684897
115* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95698430
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.93399843
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93224213
118VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92897515
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.91541660
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91286554
121CBP_20019798_ChIP-Seq_JUKART_Human0.91286554
122DROSHA_22980978_ChIP-Seq_HELA_Human0.90776004
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90541191
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90381295
125* RING1B_27294783_Chip-Seq_ESCs_Mouse0.90239367
126BCAT_22108803_ChIP-Seq_LS180_Human0.89920363
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.89453338
128P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88241043
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.87563972
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87101601
131RUNX2_22187159_ChIP-Seq_PCA_Human0.86358597
132NANOG_20526341_ChIP-Seq_ESCs_Human0.85159490
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84432743
134RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84152145
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83303774
136TBL1_22424771_ChIP-Seq_293T_Human0.82346895
137TP63_23658742_ChIP-Seq_EP156T_Human0.82319402
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82136503
139OCT1_27270436_Chip-Seq_PROSTATE_Human0.81522579
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.81248956
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80710682
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80680024
143IRF8_27001747_Chip-Seq_BMDM_Mouse0.80262974
144SALL1_21062744_ChIP-ChIP_HESCs_Human0.79999378
145RACK7_27058665_Chip-Seq_MCF-7_Human0.79904513
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78912979
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78907982
148* SOX2_21211035_ChIP-Seq_LN229_Gbm0.78625172
149AR_25329375_ChIP-Seq_VCAP_Human0.78561712
150IRF8_21731497_ChIP-ChIP_J774_Mouse0.78361936
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78179720
152IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77935747
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77860001
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77437278
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76665018
156ERA_21632823_ChIP-Seq_H3396_Human0.75820663
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.75682609
158REST_21632747_ChIP-Seq_MESCs_Mouse0.74525488
159ERG_21242973_ChIP-ChIP_JURKAT_Human0.72966258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.98517080
2MP0001346_abnormal_lacrimal_gland4.38432718
3MP0005367_renal/urinary_system_phenotyp3.79473907
4MP0000516_abnormal_urinary_system3.79473907
5MP0002132_abnormal_respiratory_system3.44534215
6MP0008004_abnormal_stomach_pH3.15410472
7MP0003136_yellow_coat_color3.12060613
8MP0005248_abnormal_Harderian_gland2.98598610
9MP0004084_abnormal_cardiac_muscle2.96171673
10MP0000685_abnormal_immune_system2.92461365
11MP0010368_abnormal_lymphatic_system2.91705942
12MP0002234_abnormal_pharynx_morphology2.84207430
13MP0000383_abnormal_hair_follicle2.78870349
14MP0003453_abnormal_keratinocyte_physiol2.45889166
15MP0008789_abnormal_olfactory_epithelium2.43998403
16MP0001984_abnormal_olfaction2.36579035
17MP0009697_abnormal_copulation2.31200706
18MP0001835_abnormal_antigen_presentation2.30558066
19MP0000678_abnormal_parathyroid_gland2.27891484
20MP0001986_abnormal_taste_sensitivity2.23067152
21MP0010678_abnormal_skin_adnexa2.22568951
22MP0003724_increased_susceptibility_to2.21832330
23MP0003315_abnormal_perineum_morphology2.21115980
24MP0001849_ear_inflammation2.17937280
25MP0002127_abnormal_cardiovascular_syste2.11993764
26MP0000733_abnormal_muscle_development2.11646970
27MP0009278_abnormal_bone_marrow2.10196923
28MP0002102_abnormal_ear_morphology2.05741909
29MP0000579_abnormal_nail_morphology2.01710791
30MP0002938_white_spotting1.98825782
31MP0000762_abnormal_tongue_morphology1.98656227
32MP0003763_abnormal_thymus_physiology1.97745752
33MP0005671_abnormal_response_to1.95477190
34MP0010386_abnormal_urinary_bladder1.93229310
35MP0005387_immune_system_phenotype1.88617653
36MP0001790_abnormal_immune_system1.88617653
37MP0000749_muscle_degeneration1.86877790
38MP0000566_synostosis1.86003237
39MP0004264_abnormal_extraembryonic_tissu1.83942616
40MP0002098_abnormal_vibrissa_morphology1.80801478
41MP0002160_abnormal_reproductive_system1.74266065
42MP0000467_abnormal_esophagus_morphology1.73982223
43MP0004510_myositis1.73844513
44MP0001188_hyperpigmentation1.63031912
45MP0003938_abnormal_ear_development1.62584861
46MP0001664_abnormal_digestion1.61301071
47MP0010234_abnormal_vibrissa_follicle1.59848793
48MP0005646_abnormal_pituitary_gland1.58476701
49MP0010030_abnormal_orbit_morphology1.58078391
50MP0001348_abnormal_lacrimal_gland1.57543220
51MP0008007_abnormal_cellular_replicative1.54212379
52MP0000613_abnormal_salivary_gland1.51490333
53MP0009250_abnormal_appendicular_skeleto1.50891592
54MP0005503_abnormal_tendon_morphology1.47463006
55MP0004859_abnormal_synaptic_plasticity1.46451011
56MP0005187_abnormal_penis_morphology1.46237559
57MP0002638_abnormal_pupillary_reflex1.44803257
58MP0001502_abnormal_circadian_rhythm1.40914482
59MP0009780_abnormal_chondrocyte_physiolo1.39202799
60MP0002932_abnormal_joint_morphology1.37530678
61MP0005310_abnormal_salivary_gland1.33940919
62MP0002295_abnormal_pulmonary_circulatio1.32090077
63MP0005620_abnormal_muscle_contractility1.30739715
64MP0002277_abnormal_respiratory_mucosa1.29837280
65MP0004272_abnormal_basement_membrane1.27056532
66MP0001485_abnormal_pinna_reflex1.26162483
67MP0001661_extended_life_span1.25142008
68MP0005595_abnormal_vascular_smooth1.24712588
69MP0001486_abnormal_startle_reflex1.24550653
70MP0000538_abnormal_urinary_bladder1.23568217
71MP0002184_abnormal_innervation1.22973909
72MP0000049_abnormal_middle_ear1.22822929
73MP0002233_abnormal_nose_morphology1.21794735
74MP0005377_hearing/vestibular/ear_phenot1.20449841
75MP0003878_abnormal_ear_physiology1.20449841
76MP0005508_abnormal_skeleton_morphology1.19799575
77MP0006072_abnormal_retinal_apoptosis1.19648123
78MP0003941_abnormal_skin_development1.17936919
79MP0003635_abnormal_synaptic_transmissio1.16905889
80MP0005409_darkened_coat_color1.16854111
81MP0004145_abnormal_muscle_electrophysio1.16001368
82MP0009785_altered_susceptibility_to1.14995338
83MP0006276_abnormal_autonomic_nervous1.14779021
84MP0001270_distended_abdomen1.14706420
85MP0003806_abnormal_nucleotide_metabolis1.13148085
86MP0005253_abnormal_eye_physiology1.12327896
87MP0000747_muscle_weakness1.11118395
88MP0003755_abnormal_palate_morphology1.10301170
89MP0002060_abnormal_skin_morphology1.09930070
90MP0005623_abnormal_meninges_morphology1.04859978
91MP0000026_abnormal_inner_ear1.04832658
92MP0000703_abnormal_thymus_morphology1.03823963
93MP0000759_abnormal_skeletal_muscle1.01408324
94MP0005023_abnormal_wound_healing1.00392719
95MP0001299_abnormal_eye_distance/0.97609256
96MP0001873_stomach_inflammation0.96966257
97MP0004085_abnormal_heartbeat0.96429173
98MP0006138_congestive_heart_failure0.95487774
99MP0005410_abnormal_fertilization0.94789010
100MP0002269_muscular_atrophy0.94381453
101MP0002009_preneoplasia0.94018652
102MP0003011_delayed_dark_adaptation0.93930785
103MP0003942_abnormal_urinary_system0.93917899
104MP0002166_altered_tumor_susceptibility0.93684000
105MP0002177_abnormal_outer_ear0.91816153
106MP0003632_abnormal_nervous_system0.91331098
107MP0003045_fibrosis0.91325323
108MP0001851_eye_inflammation0.90507229
109MP0003385_abnormal_body_wall0.90232895
110MP0000537_abnormal_urethra_morphology0.88759944
111MP0002752_abnormal_somatic_nervous0.88028082
112MP0005394_taste/olfaction_phenotype0.87762620
113MP0005499_abnormal_olfactory_system0.87762620
114MP0000428_abnormal_craniofacial_morphol0.87675194
115MP0001216_abnormal_epidermal_layer0.87221209
116MP0000163_abnormal_cartilage_morphology0.86649124
117MP0000534_abnormal_ureter_morphology0.86369917
118MP0001529_abnormal_vocalization0.86361082
119MP0002837_dystrophic_cardiac_calcinosis0.86099249
120MP0000751_myopathy0.85360699
121MP0005390_skeleton_phenotype0.85200457
122MP0003880_abnormal_central_pattern0.84366250
123MP0002114_abnormal_axial_skeleton0.84241013
124MP0008438_abnormal_cutaneous_collagen0.84156015
125MP0004087_abnormal_muscle_fiber0.83914375
126MP0006082_CNS_inflammation0.82908238
127MP0003868_abnormal_feces_composition0.82325162
128MP0010155_abnormal_intestine_physiology0.81966024
129MP0000681_abnormal_thyroid_gland0.81419414
130MP0002116_abnormal_craniofacial_bone0.81092349
131MP0009046_muscle_twitch0.78858166
132MP0001963_abnormal_hearing_physiology0.78713070
133MP0000858_altered_metastatic_potential0.78490797
134MP0001756_abnormal_urination0.78487393
135MP0005025_abnormal_response_to0.78479069
136MP0000377_abnormal_hair_follicle0.78064115
137MP0001905_abnormal_dopamine_level0.78014170
138MP0000230_abnormal_systemic_arterial0.77803561
139MP0002148_abnormal_hypersensitivity_rea0.76400999
140MP0002249_abnormal_larynx_morphology0.76141582
141MP0002006_tumorigenesis0.74352221
142MP0002572_abnormal_emotion/affect_behav0.74034022
143MP0002282_abnormal_trachea_morphology0.74007981
144MP0005391_vision/eye_phenotype0.73845580
145MP0005000_abnormal_immune_tolerance0.73684752
146MP0001853_heart_inflammation0.72739610
147MP0004036_abnormal_muscle_relaxation0.72430740
148MP0003303_peritoneal_inflammation0.71665586
149MP0003935_abnormal_craniofacial_develop0.70837560
150MP0004947_skin_inflammation0.69978309
151MP0002111_abnormal_tail_morphology0.69284971
152MP0003879_abnormal_hair_cell0.68999416
153MP0002115_abnormal_skeleton_extremities0.68499380
154MP0001340_abnormal_eyelid_morphology0.68122882
155MP0004215_abnormal_myocardial_fiber0.67968444
156MP0002405_respiratory_system_inflammati0.67308236
157MP0005275_abnormal_skin_tensile0.66482626
158MP0002933_joint_inflammation0.66335970
159MP0000470_abnormal_stomach_morphology0.66300084
160MP0001800_abnormal_humoral_immune0.65855328
161MP0000462_abnormal_digestive_system0.65389765
162MP0002109_abnormal_limb_morphology0.65322778
163MP0002108_abnormal_muscle_morphology0.64498968
164MP0002972_abnormal_cardiac_muscle0.64180883
165MP0003566_abnormal_cell_adhesion0.62401252

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)7.04372131
2Onycholysis (HP:0001806)6.75192432
3Atrophic scars (HP:0001075)6.07370519
4Nasolacrimal duct obstruction (HP:0000579)5.78533769
5Right ventricular cardiomyopathy (HP:0011663)5.77634001
6Alacrima (HP:0000522)5.37864392
7Abnormality of the columella (HP:0009929)5.30490730
8Abnormality of the lacrimal duct (HP:0011481)5.05826013
9Lip pit (HP:0100267)4.92783506
10Aortic aneurysm (HP:0004942)4.90443608
11Fragile nails (HP:0001808)4.84891431
12Plantar hyperkeratosis (HP:0007556)4.68240908
13Preauricular pit (HP:0004467)4.60876828
14Periauricular skin pits (HP:0100277)4.60876828
15Chronic otitis media (HP:0000389)4.53935065
16Mixed hearing impairment (HP:0000410)4.51332639
17Abnormality of the nasolacrimal system (HP:0000614)4.48204983
18Decreased lacrimation (HP:0000633)4.44884212
19Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.40890139
20Centrally nucleated skeletal muscle fibers (HP:0003687)4.28143543
21Scapular winging (HP:0003691)4.04165855
22Aplasia involving bones of the upper limbs (HP:0009823)4.03887434
23Aplasia of the phalanges of the hand (HP:0009802)4.03887434
24Aplasia involving bones of the extremities (HP:0009825)4.03887434
25Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.00517777
26Reduced antithrombin III activity (HP:0001976)3.69229334
27Microretrognathia (HP:0000308)3.67314793
28Type 1 muscle fiber predominance (HP:0003803)3.62926974
29Fatigable weakness (HP:0003473)3.59437237
30Abnormality of the neuromuscular junction (HP:0003398)3.59437237
31Thoracic kyphosis (HP:0002942)3.52144927
32Abnormality of the frontal sinuses (HP:0002687)3.47263297
33Partial duplication of thumb phalanx (HP:0009944)3.40865778
34Abnormal ciliary motility (HP:0012262)3.37411310
35Pili torti (HP:0003777)3.36760167
36Skin pits (HP:0100276)3.35489419
37Recurrent corneal erosions (HP:0000495)3.30741110
38Atonic seizures (HP:0010819)3.23709745
39Weak cry (HP:0001612)3.23497062
40Partial duplication of the phalanx of hand (HP:0009999)3.21425640
41Chronic mucocutaneous candidiasis (HP:0002728)3.17386904
42Recurrent cutaneous fungal infections (HP:0011370)3.17386904
43Hypoplasia of dental enamel (HP:0006297)3.14613865
44Nail dystrophy (HP:0008404)3.10806374
45High anterior hairline (HP:0009890)3.10365449
46Ventricular tachycardia (HP:0004756)3.04746322
47Sensory axonal neuropathy (HP:0003390)3.02753436
48Aplasia cutis congenita (HP:0001057)3.01376896
49Papilledema (HP:0001085)2.96562475
50Eczematoid dermatitis (HP:0000976)2.96108720
51Selective tooth agenesis (HP:0001592)2.92495616
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.89723315
53Natal tooth (HP:0000695)2.88640412
54Abnormality of the incisor (HP:0000676)2.83393325
55Esophageal atresia (HP:0002032)2.81371372
56Spinal rigidity (HP:0003306)2.80419194
57Abnormal respiratory motile cilium physiology (HP:0012261)2.76634544
58Nasal polyposis (HP:0100582)2.76574455
59Retinal dysplasia (HP:0007973)2.71424553
60Distal lower limb muscle weakness (HP:0009053)2.69903001
61Follicular hyperkeratosis (HP:0007502)2.61798034
62Ureteral stenosis (HP:0000071)2.60187765
63Nonprogressive disorder (HP:0003680)2.55948677
64Abnormality of the gastric mucosa (HP:0004295)2.53893732
65Palmoplantar hyperkeratosis (HP:0000972)2.52702078
66Turricephaly (HP:0000262)2.51776371
67Vitreoretinal degeneration (HP:0000655)2.51508853
68Bifid scrotum (HP:0000048)2.51293522
69Abnormality of incisor morphology (HP:0011063)2.47829241
70Abnormality of the calf musculature (HP:0001430)2.46864165
71Cutaneous finger syndactyly (HP:0010554)2.46344520
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44888903
73Abnormality of the antihelix (HP:0009738)2.44525584
74Fragile skin (HP:0001030)2.43191763
75Type 2 muscle fiber atrophy (HP:0003554)2.42772744
76Abnormality of the shoulder girdle musculature (HP:0001435)2.39685136
77Taurodontia (HP:0000679)2.38218758
78Abnormality of permanent molar morphology (HP:0011071)2.38218758
79Abnormality of the dental root (HP:0006486)2.38218758
80Abnormal respiratory epithelium morphology (HP:0012253)2.37616278
81Abnormal respiratory motile cilium morphology (HP:0005938)2.37616278
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.35968773
83Absent/shortened dynein arms (HP:0200106)2.35968773
84Abnormality of the intrinsic pathway (HP:0010989)2.35206156
85Intellectual disability, moderate (HP:0002342)2.34133050
86Palmar hyperkeratosis (HP:0010765)2.33408333
87Ureteral obstruction (HP:0006000)2.32796888
88Pterygium (HP:0001059)2.32226038
89Hypoplastic nipples (HP:0002557)2.32117486
90Muscle hypertrophy of the lower extremities (HP:0008968)2.30564851
91Self-mutilation (HP:0000742)2.29507771
92Thick nail (HP:0001805)2.26209946
93Hypoventilation (HP:0002791)2.23719376
94Ventricular fibrillation (HP:0001663)2.23228008
95Abnormality of molar (HP:0011077)2.23000524
96Abnormality of molar morphology (HP:0011070)2.23000524
97Sprengel anomaly (HP:0000912)2.22308288
98EMG: myopathic abnormalities (HP:0003458)2.20808727
99Buphthalmos (HP:0000557)2.20156581
100Aortic dissection (HP:0002647)2.19998649
101Hyporeflexia of lower limbs (HP:0002600)2.19396844
102Ankle contracture (HP:0006466)2.18573717
103Muscle fiber atrophy (HP:0100295)2.17758689
104Short 4th metacarpal (HP:0010044)2.17650108
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17650108
106Panhypogammaglobulinemia (HP:0003139)2.15551822
107Abnormality of the thoracic spine (HP:0100711)2.14751645
108Abnormality of the nasal mucosa (HP:0000433)2.14743635
109Advanced eruption of teeth (HP:0006288)2.14247120
110Postural instability (HP:0002172)2.13935503
111Facial hemangioma (HP:0000329)2.13690350
112Hypotrichosis (HP:0001006)2.13412958
113Resting tremor (HP:0002322)2.12910426
114Abnormality of the dental pulp (HP:0006479)2.11728129
115Ventricular arrhythmia (HP:0004308)2.10898850
116Calf muscle hypertrophy (HP:0008981)2.10147816
117Periodontitis (HP:0000704)2.08893348
118Palpitations (HP:0001962)2.08153357
119Muscular dystrophy (HP:0003560)2.07832011
120Cutaneous syndactyly (HP:0012725)2.07481375
121Bulbar palsy (HP:0001283)2.06089182
122Rhinitis (HP:0012384)2.04984548
123Thoracolumbar scoliosis (HP:0002944)2.04973056
124Benign neoplasm of the central nervous system (HP:0100835)2.04156289
125Sudden death (HP:0001699)2.04046162
126Chronic sinusitis (HP:0011109)2.03242998
127Hypoplasia of the maxilla (HP:0000327)2.00742568
128Woolly hair (HP:0002224)1.99921055
129Exercise-induced myalgia (HP:0003738)1.99312171
130Median cleft lip (HP:0000161)1.98779049
131Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98123309
132Difficulty running (HP:0009046)1.97822478
133Ridged nail (HP:0001807)1.97460625
134Atresia of the external auditory canal (HP:0000413)1.95592100
135Cupped ear (HP:0000378)1.95348783
136Renal dysplasia (HP:0000110)1.95232374
137Abnormal hair laboratory examination (HP:0003328)1.94788781
138Recurrent fungal infections (HP:0002841)1.92821881
139Exercise-induced muscle cramps (HP:0003710)1.92306552
140Colitis (HP:0002583)1.91875566
141Muscle fiber inclusion bodies (HP:0100299)1.91700130
142Preaxial foot polydactyly (HP:0001841)1.90982690
143Recurrent bronchitis (HP:0002837)1.90186740
144Capillary hemangiomas (HP:0005306)1.89623296
145Unsteady gait (HP:0002317)1.89619769
146Nemaline bodies (HP:0003798)1.87768797
147Hypoplasia of the iris (HP:0007676)1.87761864
148Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86989754
149Premature skin wrinkling (HP:0100678)1.86917658
150Growth hormone excess (HP:0000845)1.86907913
151Absent speech (HP:0001344)1.86685594
152Retinal detachment (HP:0000541)1.83807308
153Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.82725022
154Sparse scalp hair (HP:0002209)1.82689506
155Congenital sensorineural hearing impairment (HP:0008527)1.82685439
156Hypodontia (HP:0000668)1.82048023
157Midline defect of the nose (HP:0004122)1.77589068
158Rimmed vacuoles (HP:0003805)1.74749894
159Unilateral renal agenesis (HP:0000122)1.73802863
160Hyperphosphatemia (HP:0002905)1.73411219
161Male pseudohermaphroditism (HP:0000037)1.72320863
162Congenital glaucoma (HP:0001087)1.71309450
163Inflammation of the large intestine (HP:0002037)1.70196461
164Xerostomia (HP:0000217)1.70144237
165Clumsiness (HP:0002312)1.70099918
166Abnormality of the parietal bone (HP:0002696)1.69490942
167Sudden cardiac death (HP:0001645)1.66941397
168Abnormal blistering of the skin (HP:0008066)1.66710203
169Asymmetry of the thorax (HP:0001555)1.66564085
170Amelogenesis imperfecta (HP:0000705)1.66535024
171Morphological abnormality of the middle ear (HP:0008609)1.65559274
172Slender build (HP:0001533)1.64039751
173Abnormality of skeletal muscle fiber size (HP:0012084)1.62398475
174Round ear (HP:0100830)1.62350673
175Gastrointestinal atresia (HP:0002589)1.60708689
176Myotonia (HP:0002486)1.58668322
177Overriding aorta (HP:0002623)1.58434736
178Shallow orbits (HP:0000586)1.58416960
179Increased variability in muscle fiber diameter (HP:0003557)1.58099641
180Syncope (HP:0001279)1.57115876
181Stomach cancer (HP:0012126)1.54960503
182Mildly elevated creatine phosphokinase (HP:0008180)1.54724854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.05378684
2PINK14.87152930
3TSSK64.53004492
4LATS24.02295581
5NEK23.63266266
6STK38L3.24295928
7EPHA33.06800521
8FGFR42.89698596
9MAP3K142.76926799
10TTN2.75664594
11MARK32.44851228
12JAK32.43715214
13EPHB12.38696239
14ITK2.25093600
15TYK22.17959335
16MAP2K72.09273497
17TNIK2.04763492
18BTK1.96658047
19IKBKE1.90581098
20SGK2231.86045724
21SGK4941.86045724
22RPS6KB21.85150296
23EEF2K1.83111285
24NME11.82910122
25MOS1.78119219
26FGFR31.72477558
27JAK11.71322396
28RIPK11.67530082
29VRK11.54017612
30NME21.50279186
31ERBB31.49573412
32LATS11.46453895
33DMPK1.45221272
34PIK3CG1.43451646
35MAP3K91.42747432
36STK381.39640624
37OBSCN1.39620633
38BMPR1B1.37470553
39FGFR21.34189619
40MARK11.29767041
41DDR21.29263469
42PTK61.28771347
43SGK21.28009282
44CDC42BPA1.27213890
45TGFBR11.26906149
46MST41.26340071
47MAPKAPK31.26269077
48CLK11.25220286
49SIK31.25034875
50MAPK121.24613239
51TIE11.24015599
52NLK1.21854667
53MAPKAPK51.20581294
54ARAF1.20282455
55PTK21.19729880
56DYRK21.15618158
57CDK31.12110170
58DYRK31.09763815
59TBK11.08797242
60MAP3K101.08684263
61DAPK31.08352800
62CHUK1.07788290
63TXK1.03860945
64JAK21.02905024
65FRK1.00167451
66SIK10.98179842
67TLK10.97642907
68MAP3K130.93536992
69TEC0.90642996
70MYLK0.90561228
71CASK0.89655979
72MAPKAPK20.89615435
73FER0.89560053
74STK30.87907497
75NEK60.87334632
76EPHB20.84945822
77RPS6KB10.84474414
78CSNK1A1L0.84032266
79CDK120.82083295
80MELK0.80470794
81PAK20.79166978
82TRPM70.79028693
83HIPK20.75907391
84PHKG20.75319819
85PHKG10.75319819
86MAP3K70.75265769
87PAK10.75106999
88TAOK10.73372835
89MAP2K20.73125388
90ICK0.72880425
91CAMK10.72679177
92IRAK20.72131789
93IKBKB0.69918149
94TGFBR20.69685313
95MAP3K10.69606086
96SGK30.68021751
97CAMK2G0.67858553
98EIF2AK30.65586734
99ERBB20.64792515
100AKT20.64772045
101AKT30.64578087
102ROCK10.63417041
103MAPK130.63357898
104LCK0.61906769
105MKNK20.59729264
106PAK60.59043108
107MAP2K60.55827675
108DAPK20.55769845
109MTOR0.55711877
110ZAK0.54787944
111TRIB30.53947062
112MAP3K30.53827300
113NTRK20.53287391
114NUAK10.53155174
115PIK3CA0.52773304
116GRK50.52575290
117CSK0.52006740
118PRKCQ0.51847507
119RET0.51398964
120ADRBK20.49666480
121CSNK1G30.48559032
122CDK50.48126623
123CDK80.45521409
124CSNK1G10.45243742
125PDGFRA0.45034775
126PKN10.44626072
127PDPK10.43605375
128ILK0.43521786
129RPS6KA20.43259850
130RPS6KC10.42725413
131RPS6KL10.42725413
132RPS6KA60.42200052
133KIT0.41223841
134CSNK1G20.39612933
135EGFR0.39474133
136MAP3K120.39065484
137NTRK10.38879470
138SIK20.38795059
139MKNK10.38762323
140CDK140.38022994
141GSK3A0.37214100
142ROCK20.36450460
143PRKD10.36240079
144PRKG10.36109877
145GRK10.34953798
146INSRR0.34768369
147PTK2B0.34685761
148MAPK30.31976200
149PKN20.31806360
150MINK10.29642555
151RPS6KA10.29016596
152CAMK2B0.28952211
153IRAK10.27855941
154MAPK70.27211425
155BCR0.27201950
156CAMK40.26946053
157SRC0.26637414
158PRKG20.26025568
159LRRK20.25861514
160EIF2AK20.25469234
161MAP3K50.25038371
162RPS6KA40.24879058
163PAK30.24013539
164INSR0.23501382
165LMTK20.23296321
166IGF1R0.23180704
167CSNK1D0.21552782

Predicted pathways (KEGG)

RankGene SetZ-score
1Antigen processing and presentation_Homo sapiens_hsa046123.54561196
2Olfactory transduction_Homo sapiens_hsa047403.45495112
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.86593806
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.60309805
5Primary immunodeficiency_Homo sapiens_hsa053402.32782125
6Graft-versus-host disease_Homo sapiens_hsa053322.25928260
7Toxoplasmosis_Homo sapiens_hsa051452.24574308
8Butanoate metabolism_Homo sapiens_hsa006502.21902537
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20300849
10Asthma_Homo sapiens_hsa053102.19968800
11Vascular smooth muscle contraction_Homo sapiens_hsa042702.17298445
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.12383215
13Nitrogen metabolism_Homo sapiens_hsa009102.06402837
14Leishmaniasis_Homo sapiens_hsa051402.03163935
15cGMP-PKG signaling pathway_Homo sapiens_hsa040222.01374986
16Circadian entrainment_Homo sapiens_hsa047132.00478264
17ECM-receptor interaction_Homo sapiens_hsa045121.96540695
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.87652781
19Chemical carcinogenesis_Homo sapiens_hsa052041.87125009
20Renin secretion_Homo sapiens_hsa049241.86889672
21Measles_Homo sapiens_hsa051621.86547000
22Circadian rhythm_Homo sapiens_hsa047101.80526710
23TNF signaling pathway_Homo sapiens_hsa046681.78729610
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77827910
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75574524
26Gap junction_Homo sapiens_hsa045401.74862758
27Osteoclast differentiation_Homo sapiens_hsa043801.74660745
28Influenza A_Homo sapiens_hsa051641.73262968
29Oxytocin signaling pathway_Homo sapiens_hsa049211.73260362
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.72929373
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72755056
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.72303268
33Legionellosis_Homo sapiens_hsa051341.70357392
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67834307
35Salivary secretion_Homo sapiens_hsa049701.62106115
36Notch signaling pathway_Homo sapiens_hsa043301.58986441
37Arginine biosynthesis_Homo sapiens_hsa002201.58267285
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56381712
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.53096807
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52006750
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46675742
42Dilated cardiomyopathy_Homo sapiens_hsa054141.46530405
43Viral myocarditis_Homo sapiens_hsa054161.45738376
44Calcium signaling pathway_Homo sapiens_hsa040201.42741196
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.42332792
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40206620
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39050710
48Allograft rejection_Homo sapiens_hsa053301.38365554
49T cell receptor signaling pathway_Homo sapiens_hsa046601.37602880
50Herpes simplex infection_Homo sapiens_hsa051681.36410657
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35684994
52Focal adhesion_Homo sapiens_hsa045101.35009003
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29094061
54Phenylalanine metabolism_Homo sapiens_hsa003601.28909128
55beta-Alanine metabolism_Homo sapiens_hsa004101.28440583
56Amoebiasis_Homo sapiens_hsa051461.25798653
57Ovarian steroidogenesis_Homo sapiens_hsa049131.24578217
58Small cell lung cancer_Homo sapiens_hsa052221.21946464
59Chemokine signaling pathway_Homo sapiens_hsa040621.21788046
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20914224
61Rheumatoid arthritis_Homo sapiens_hsa053231.20178461
62NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19607462
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14539462
64GABAergic synapse_Homo sapiens_hsa047271.14038790
65Basal cell carcinoma_Homo sapiens_hsa052171.09744358
66Cholinergic synapse_Homo sapiens_hsa047251.08185342
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07953571
68Prolactin signaling pathway_Homo sapiens_hsa049171.07443139
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07313525
70Leukocyte transendothelial migration_Homo sapiens_hsa046701.07254614
71Endometrial cancer_Homo sapiens_hsa052131.05908146
72Insulin secretion_Homo sapiens_hsa049111.05438624
73Hippo signaling pathway_Homo sapiens_hsa043901.03682473
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03179366
75Pertussis_Homo sapiens_hsa051331.03054753
76Melanoma_Homo sapiens_hsa052181.02768144
77Type I diabetes mellitus_Homo sapiens_hsa049401.01700561
78cAMP signaling pathway_Homo sapiens_hsa040241.00307043
79Autoimmune thyroid disease_Homo sapiens_hsa053200.98325830
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97809624
81Glutamatergic synapse_Homo sapiens_hsa047240.94403860
82Insulin resistance_Homo sapiens_hsa049310.94206286
83ABC transporters_Homo sapiens_hsa020100.91682517
84Estrogen signaling pathway_Homo sapiens_hsa049150.90878163
85Adherens junction_Homo sapiens_hsa045200.90579251
86Hepatitis B_Homo sapiens_hsa051610.90495276
87Tuberculosis_Homo sapiens_hsa051520.87588906
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.87468877
89Hepatitis C_Homo sapiens_hsa051600.86005259
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85898451
91Bile secretion_Homo sapiens_hsa049760.85745468
92Hematopoietic cell lineage_Homo sapiens_hsa046400.84328425
93Nicotine addiction_Homo sapiens_hsa050330.83015045
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82126735
95Prostate cancer_Homo sapiens_hsa052150.81718668
96HTLV-I infection_Homo sapiens_hsa051660.81224749
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80562215
98Malaria_Homo sapiens_hsa051440.79299251
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78537714
100Apoptosis_Homo sapiens_hsa042100.77331258
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77279004
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76333616
103Pancreatic cancer_Homo sapiens_hsa052120.75563272
104Dorso-ventral axis formation_Homo sapiens_hsa043200.75204520
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74787525
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73859234
107Proteoglycans in cancer_Homo sapiens_hsa052050.72844335
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72686995
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71866807
110Pancreatic secretion_Homo sapiens_hsa049720.71740895
111African trypanosomiasis_Homo sapiens_hsa051430.71574853
112AMPK signaling pathway_Homo sapiens_hsa041520.71558829
113Morphine addiction_Homo sapiens_hsa050320.71365024
114Histidine metabolism_Homo sapiens_hsa003400.70551468
115Pathways in cancer_Homo sapiens_hsa052000.70505271
116Salmonella infection_Homo sapiens_hsa051320.70306200
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68917689
118Tyrosine metabolism_Homo sapiens_hsa003500.68679838
119B cell receptor signaling pathway_Homo sapiens_hsa046620.68260702
120Type II diabetes mellitus_Homo sapiens_hsa049300.67716704
121Axon guidance_Homo sapiens_hsa043600.67217875
122Long-term potentiation_Homo sapiens_hsa047200.67154942
123Mineral absorption_Homo sapiens_hsa049780.66700761
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66698386
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65681667
126Cocaine addiction_Homo sapiens_hsa050300.65187821
127MAPK signaling pathway_Homo sapiens_hsa040100.64757344
128PPAR signaling pathway_Homo sapiens_hsa033200.64484058
129Colorectal cancer_Homo sapiens_hsa052100.63908566
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63571672
131Hedgehog signaling pathway_Homo sapiens_hsa043400.60906170
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60406449
133Taste transduction_Homo sapiens_hsa047420.58269756
134Prion diseases_Homo sapiens_hsa050200.58022006
135Glucagon signaling pathway_Homo sapiens_hsa049220.57259127
136Melanogenesis_Homo sapiens_hsa049160.56964203
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56193107
138Platelet activation_Homo sapiens_hsa046110.56061080
139Arginine and proline metabolism_Homo sapiens_hsa003300.55474657
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.55225714
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55171821
142Starch and sucrose metabolism_Homo sapiens_hsa005000.54942965
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53171354
144Tight junction_Homo sapiens_hsa045300.53019259
145Rap1 signaling pathway_Homo sapiens_hsa040150.52130987
146Chronic myeloid leukemia_Homo sapiens_hsa052200.51517928
147Renal cell carcinoma_Homo sapiens_hsa052110.51080813
148FoxO signaling pathway_Homo sapiens_hsa040680.50910305
149Dopaminergic synapse_Homo sapiens_hsa047280.50909402
150TGF-beta signaling pathway_Homo sapiens_hsa043500.50402618
151Alcoholism_Homo sapiens_hsa050340.50181903
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.50158186
153Shigellosis_Homo sapiens_hsa051310.48762578
154Retinol metabolism_Homo sapiens_hsa008300.47770180
155Amphetamine addiction_Homo sapiens_hsa050310.47071043
156Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46484087
157Protein digestion and absorption_Homo sapiens_hsa049740.45491626
158Epstein-Barr virus infection_Homo sapiens_hsa051690.44224417
159Acute myeloid leukemia_Homo sapiens_hsa052210.43739568
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42128028
161Purine metabolism_Homo sapiens_hsa002300.42079061
162Cardiac muscle contraction_Homo sapiens_hsa042600.41559546
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41299164
164Gastric acid secretion_Homo sapiens_hsa049710.41127058
165Wnt signaling pathway_Homo sapiens_hsa043100.40450505
166Sphingolipid signaling pathway_Homo sapiens_hsa040710.38399403
167Long-term depression_Homo sapiens_hsa047300.36803492
168Choline metabolism in cancer_Homo sapiens_hsa052310.36691772
169Ras signaling pathway_Homo sapiens_hsa040140.35554022
170Oocyte meiosis_Homo sapiens_hsa041140.33628695
171Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33421492
172Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32858794

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »