WHAMM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.71971957
2L-phenylalanine catabolic process (GO:0006559)6.71971957
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.49164457
4L-phenylalanine metabolic process (GO:0006558)6.49164457
5aromatic amino acid family catabolic process (GO:0009074)6.22502926
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.89253822
7indole-containing compound catabolic process (GO:0042436)5.85594214
8indolalkylamine catabolic process (GO:0046218)5.85594214
9tryptophan catabolic process (GO:0006569)5.85594214
10kynurenine metabolic process (GO:0070189)5.71331019
11urea cycle (GO:0000050)5.61779552
12urea metabolic process (GO:0019627)5.61779552
13sulfur amino acid catabolic process (GO:0000098)5.59836530
14cysteine metabolic process (GO:0006534)5.46796503
15tryptophan metabolic process (GO:0006568)5.42243637
16bile acid biosynthetic process (GO:0006699)5.32433996
17nitrogen cycle metabolic process (GO:0071941)5.20897419
18glyoxylate metabolic process (GO:0046487)5.18268437
19complement activation, alternative pathway (GO:0006957)5.02961314
20serine family amino acid catabolic process (GO:0009071)5.02471807
21alpha-linolenic acid metabolic process (GO:0036109)5.00839541
22regulation of protein activation cascade (GO:2000257)4.99301152
23high-density lipoprotein particle remodeling (GO:0034375)4.95023295
24protein carboxylation (GO:0018214)4.93678500
25peptidyl-glutamic acid carboxylation (GO:0017187)4.93678500
26bile acid metabolic process (GO:0008206)4.87952287
27negative regulation of fibrinolysis (GO:0051918)4.78358139
28tolerance induction (GO:0002507)4.76351069
29regulation of triglyceride catabolic process (GO:0010896)4.73435489
30regulation of fibrinolysis (GO:0051917)4.73317079
31regulation of complement activation (GO:0030449)4.69427936
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.61525326
33plasma lipoprotein particle remodeling (GO:0034369)4.60230477
34protein-lipid complex remodeling (GO:0034368)4.60230477
35macromolecular complex remodeling (GO:0034367)4.60230477
36homocysteine metabolic process (GO:0050667)4.55146219
37aromatic amino acid family metabolic process (GO:0009072)4.53386114
38bile acid and bile salt transport (GO:0015721)4.50890157
39phospholipid efflux (GO:0033700)4.45298044
40regulation of cholesterol esterification (GO:0010872)4.42444740
41acylglycerol homeostasis (GO:0055090)4.37403983
42triglyceride homeostasis (GO:0070328)4.37403983
43amino-acid betaine metabolic process (GO:0006577)4.34531649
44negative regulation of cholesterol transport (GO:0032375)4.33097502
45negative regulation of sterol transport (GO:0032372)4.33097502
46reverse cholesterol transport (GO:0043691)4.30226240
47coenzyme catabolic process (GO:0009109)4.25920969
48alpha-amino acid catabolic process (GO:1901606)4.22688936
49plasma lipoprotein particle clearance (GO:0034381)4.19506796
50low-density lipoprotein particle remodeling (GO:0034374)4.19387897
51tyrosine metabolic process (GO:0006570)4.12531176
52glycine metabolic process (GO:0006544)4.11884689
53plasma lipoprotein particle assembly (GO:0034377)4.06888577
54indolalkylamine metabolic process (GO:0006586)4.05190531
55lysine metabolic process (GO:0006553)4.03033201
56lysine catabolic process (GO:0006554)4.03033201
57amine catabolic process (GO:0009310)3.96309032
58cellular biogenic amine catabolic process (GO:0042402)3.96309032
59cholesterol efflux (GO:0033344)3.96002988
60serine family amino acid metabolic process (GO:0009069)3.92781842
61cellular amino acid catabolic process (GO:0009063)3.92646316
62regulation of cholesterol homeostasis (GO:2000188)3.91195438
63cellular modified amino acid catabolic process (GO:0042219)3.90969775
64ethanol oxidation (GO:0006069)3.87262176
65glutamate metabolic process (GO:0006536)3.85986156
66imidazole-containing compound metabolic process (GO:0052803)3.85913427
67cellular glucuronidation (GO:0052695)3.83037686
68arginine metabolic process (GO:0006525)3.81743135
69complement activation, classical pathway (GO:0006958)3.77694738
70very-low-density lipoprotein particle assembly (GO:0034379)3.76954536
71plasma lipoprotein particle organization (GO:0071827)3.74953538
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74163923
73protein K11-linked deubiquitination (GO:0035871)3.71270638
74positive regulation of lipid catabolic process (GO:0050996)3.71158136
75regulation of bile acid biosynthetic process (GO:0070857)3.70901527
76protein-lipid complex assembly (GO:0065005)3.68789626
77activated T cell proliferation (GO:0050798)3.68625966
78dicarboxylic acid biosynthetic process (GO:0043650)3.68281288
79positive regulation of lipoprotein lipase activity (GO:0051006)3.67233950
80positive regulation of triglyceride lipase activity (GO:0061365)3.67233950
81fucose catabolic process (GO:0019317)3.66781775
82L-fucose metabolic process (GO:0042354)3.66781775
83L-fucose catabolic process (GO:0042355)3.66781775
84benzene-containing compound metabolic process (GO:0042537)3.66644835
85NAD biosynthetic process (GO:0009435)3.66043950
86complement activation (GO:0006956)3.65734202
87cofactor catabolic process (GO:0051187)3.63979850
88pyridine nucleotide biosynthetic process (GO:0019363)3.63979647
89nicotinamide nucleotide biosynthetic process (GO:0019359)3.63979647
90cholesterol homeostasis (GO:0042632)3.63755006
91phospholipid homeostasis (GO:0055091)3.62580938
92drug catabolic process (GO:0042737)3.60765777
93sterol homeostasis (GO:0055092)3.59027941
94protein activation cascade (GO:0072376)3.58691500
95cytolysis (GO:0019835)3.58027770
96cellular ketone body metabolic process (GO:0046950)3.57173311
97acute-phase response (GO:0006953)3.56035247
98protein-lipid complex subunit organization (GO:0071825)3.54891891
99fibrinolysis (GO:0042730)3.54104661
100blood coagulation, intrinsic pathway (GO:0007597)3.53765068
101positive regulation of gamma-delta T cell activation (GO:0046645)3.53066513
102serine family amino acid biosynthetic process (GO:0009070)3.50184601
103intestinal cholesterol absorption (GO:0030299)3.49961915
104acetyl-CoA metabolic process (GO:0006084)3.48345400
105regulation of memory T cell differentiation (GO:0043380)3.44947996
106organic acid catabolic process (GO:0016054)3.43125149
107carboxylic acid catabolic process (GO:0046395)3.43125149
108interferon-gamma production (GO:0032609)3.40444844
109flavonoid metabolic process (GO:0009812)3.39703673
110negative T cell selection (GO:0043383)3.37647887
111short-chain fatty acid metabolic process (GO:0046459)3.34195074
112behavioral response to nicotine (GO:0035095)3.24590165
113positive regulation of defense response to virus by host (GO:0002230)3.20999236
114regulation of gamma-delta T cell activation (GO:0046643)3.19147700
115negative thymic T cell selection (GO:0045060)3.18950851
116regulation of B cell receptor signaling pathway (GO:0050855)3.16731154
117regulation of gamma-delta T cell differentiation (GO:0045586)3.13801858
118regulation of MHC class I biosynthetic process (GO:0045343)3.09107556
119regulation of germinal center formation (GO:0002634)3.05727561
120positive T cell selection (GO:0043368)3.04422011
121protein K63-linked deubiquitination (GO:0070536)3.02941542
122negative regulation of cell killing (GO:0031342)2.97892817
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97892817
124alpha-beta T cell differentiation (GO:0046632)2.95690853
125DNA deamination (GO:0045006)2.93201287
126negative regulation of interleukin-1 beta production (GO:0032691)2.89921883
127negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89402174
128positive regulation of mRNA catabolic process (GO:0061014)2.87666077
129alpha-beta T cell activation (GO:0046631)2.76225771
130CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.75620759
131T-helper cell differentiation (GO:0042093)2.75620759
132cellular response to exogenous dsRNA (GO:0071360)2.74761409
133histone H3-K4 trimethylation (GO:0080182)2.73168103
134CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.72154902
135regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71454094
136negative regulation of bone resorption (GO:0045779)2.70495110
137negative regulation of interleukin-1 production (GO:0032692)2.68549088
138establishment of protein localization to Golgi (GO:0072600)2.66444096
139positive regulation of granulocyte differentiation (GO:0030854)2.64565282
140regulation of defense response to virus by host (GO:0050691)2.64290931
141RNA destabilization (GO:0050779)2.63154140
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60151606
143cellular response to interleukin-15 (GO:0071350)2.58420647
144T cell selection (GO:0045058)2.58327277
145negative regulation of T cell mediated immunity (GO:0002710)2.56046962
146regulation of T cell receptor signaling pathway (GO:0050856)2.55881451
147regulation of alpha-beta T cell proliferation (GO:0046640)2.54500556
148negative regulation of cAMP-mediated signaling (GO:0043951)2.54145987
149positive regulation of protein homooligomerization (GO:0032464)2.53278291
150purinergic nucleotide receptor signaling pathway (GO:0035590)2.53028774
151regulation of interleukin-12 biosynthetic process (GO:0045075)2.52382054
152cAMP catabolic process (GO:0006198)2.50375411
153negative regulation of mast cell activation (GO:0033004)2.50300004
154pyrimidine ribonucleoside catabolic process (GO:0046133)2.49775404
155T cell differentiation involved in immune response (GO:0002292)2.48813233
156alpha-beta T cell differentiation involved in immune response (GO:0002293)2.48813233
157alpha-beta T cell activation involved in immune response (GO:0002287)2.48813233
158monoubiquitinated protein deubiquitination (GO:0035520)2.48550688
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45152245
160cellular response to interferon-beta (GO:0035458)2.44802155
161positive thymic T cell selection (GO:0045059)2.44275052
162response to interleukin-15 (GO:0070672)2.43621731
163regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.43190019
164positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.43190019
165negative regulation of telomere maintenance (GO:0032205)2.41164435
166negative regulation of interleukin-6 production (GO:0032715)2.40640399
167defense response to protozoan (GO:0042832)2.39230088
168cytidine deamination (GO:0009972)2.39180360
169cytidine metabolic process (GO:0046087)2.39180360
170cytidine catabolic process (GO:0006216)2.39180360
171protein targeting to Golgi (GO:0000042)2.38875567
172regulation of T-helper 1 type immune response (GO:0002825)2.38763639
173regulation of regulatory T cell differentiation (GO:0045589)2.38605332
174CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.38260644
175CD4-positive, alpha-beta T cell activation (GO:0035710)2.37106355
176antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36831699
177organelle membrane fusion (GO:0090174)2.36552372
178regulation of T cell mediated cytotoxicity (GO:0001914)2.36381472
179platelet dense granule organization (GO:0060155)2.36319418
180response to muramyl dipeptide (GO:0032495)2.36263264
181T cell migration (GO:0072678)2.35888993
182positive regulation of natural killer cell differentiation (GO:0032825)2.35172678
183regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35138784
184negative regulation of T-helper cell differentiation (GO:0045623)2.35054039
185negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.35054039
186protein K48-linked deubiquitination (GO:0071108)2.34880532
187positive regulation of alpha-beta T cell proliferation (GO:0046641)2.34203819
188detection of light stimulus involved in sensory perception (GO:0050962)2.33708647
189detection of light stimulus involved in visual perception (GO:0050908)2.33708647
190regulation of chronic inflammatory response (GO:0002676)2.33262146
191mast cell activation (GO:0045576)2.33069623
192antigen processing and presentation of endogenous antigen (GO:0019883)2.32778446
193B cell homeostasis (GO:0001782)2.31441408
194regulation of mRNA catabolic process (GO:0061013)2.30793908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.27229833
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.41222561
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.79021438
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.60764707
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63960850
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.45105816
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.22676131
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.06466141
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60175325
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.33562829
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31830452
12ZNF274_21170338_ChIP-Seq_K562_Hela2.77780435
13VDR_22108803_ChIP-Seq_LS180_Human2.63518916
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.55623379
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.47522286
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44191796
17RUNX_20019798_ChIP-Seq_JUKART_Human2.37680949
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20019372
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10335960
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01049974
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0554810
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99679722
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.99496693
24* MYB_26560356_Chip-Seq_TH2_Human1.93034982
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90865362
26ER_23166858_ChIP-Seq_MCF-7_Human1.89548480
27GBX2_23144817_ChIP-Seq_PC3_Human1.80561034
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.75882219
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75670653
30* GATA3_26560356_Chip-Seq_TH2_Human1.73716391
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70949531
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69714426
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67207032
34GATA1_22025678_ChIP-Seq_K562_Human1.60432498
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56825720
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54292275
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53987902
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53502427
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52613779
40BCAT_22108803_ChIP-Seq_LS180_Human1.51584028
41IGF1R_20145208_ChIP-Seq_DFB_Human1.50424044
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47935201
43GATA3_27048872_Chip-Seq_THYMUS_Human1.46495770
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46306010
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44923177
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43155545
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40637999
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37888974
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.32831830
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32593171
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.32264089
52* VDR_24787735_ChIP-Seq_THP-1_Human1.30587574
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27202703
54RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25997020
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25859794
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25042086
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24968820
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.22884828
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.21637791
60TAF15_26573619_Chip-Seq_HEK293_Human1.21555771
61TP53_22573176_ChIP-Seq_HFKS_Human1.21201597
62SMRT_27268052_Chip-Seq_Bcells_Human1.20550513
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19840362
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18247063
65ZNF263_19887448_ChIP-Seq_K562_Human1.17226807
66STAT3_23295773_ChIP-Seq_U87_Human1.17091096
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16247098
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14638212
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13699379
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13699379
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.13616061
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.13547220
73TCF4_23295773_ChIP-Seq_U87_Human1.12932646
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12893041
75* IRF8_27001747_Chip-Seq_BMDM_Mouse1.12538315
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11930608
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10340758
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10147443
79* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10119239
80CLOCK_20551151_ChIP-Seq_293T_Human1.09998879
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09749586
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.09749586
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.09555541
84LXR_22292898_ChIP-Seq_THP-1_Human1.08599278
85P300_19829295_ChIP-Seq_ESCs_Human1.08277536
86CBP_20019798_ChIP-Seq_JUKART_Human1.07829461
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07829461
88VDR_23849224_ChIP-Seq_CD4+_Human1.07814449
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.07195580
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05670365
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05572372
92AR_25329375_ChIP-Seq_VCAP_Human1.04270551
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03758187
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03431740
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03337207
96* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03165849
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03126883
98EWS_26573619_Chip-Seq_HEK293_Human1.03068905
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02566971
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02249533
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.01299103
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00849052
103GATA3_26560356_Chip-Seq_TH1_Human1.00607186
104GATA4_25053715_ChIP-Seq_YYC3_Human0.99590383
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98597673
106CRX_20693478_ChIP-Seq_RETINA_Mouse0.98194121
107FUS_26573619_Chip-Seq_HEK293_Human0.97884012
108EZH2_22144423_ChIP-Seq_EOC_Human0.97831243
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97639075
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96756976
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95726109
112GATA1_19941826_ChIP-Seq_K562_Human0.95547254
113MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95308804
114AR_20517297_ChIP-Seq_VCAP_Human0.94061376
115OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92872649
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92662367
117TCF4_22108803_ChIP-Seq_LS180_Human0.92486456
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92177199
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91926064
120SOX2_19829295_ChIP-Seq_ESCs_Human0.90589553
121NANOG_19829295_ChIP-Seq_ESCs_Human0.90589553
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89491826
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88880823
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88832048
125TP53_16413492_ChIP-PET_HCT116_Human0.88798161
126NCOR_22424771_ChIP-Seq_293T_Human0.88355567
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88241821
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87653159
129GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87496631
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87280421
131RARA_24833708_ChIP-Seq_LIVER_Mouse0.87124963
132GATA6_25053715_ChIP-Seq_YYC3_Human0.87009146
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86562229
134RACK7_27058665_Chip-Seq_MCF-7_Human0.86447683
135HOXB7_26014856_ChIP-Seq_BT474_Human0.85977493
136BP1_19119308_ChIP-ChIP_Hs578T_Human0.85954510
137MAF_26560356_Chip-Seq_TH1_Human0.85703103
138IRF8_21731497_ChIP-ChIP_J774_Mouse0.85610577
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85587058
140* TCF7_22412390_ChIP-Seq_EML_Mouse0.85550931
141VDR_21846776_ChIP-Seq_THP-1_Human0.84603831
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.84396622
143NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83940719
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81169167
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80623647
146GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79501135
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79206296
148SCL_19346495_ChIP-Seq_HPC-7_Human0.78671772
149RARB_24833708_ChIP-Seq_LIVER_Mouse0.78602894
150BCOR_27268052_Chip-Seq_Bcells_Human0.75484445
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74852961
152FOXO3_23340844_ChIP-Seq_DLD1_Human0.74616284
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74592741
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74281190
155KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72039074
156SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71499108
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.71475778
158PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70418935
159* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70073802
160GATA2_19941826_ChIP-Seq_K562_Human0.69669394
161ELK3_25401928_ChIP-Seq_HUVEC_Human0.69645964
162* MYB_26560356_Chip-Seq_TH1_Human0.69297485
163BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68891241
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.68735287
165* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68508699
166* MAF_26560356_Chip-Seq_TH2_Human0.68378416
167TET1_21451524_ChIP-Seq_MESCs_Mouse0.68090506
168NCOR1_26117541_ChIP-Seq_K562_Human0.67599007
169SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67391590
170CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66713604
171CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66284783
172KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66190207
173E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.65914617
174FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65913954
175PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65832471
176SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65104665
177MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.64383002
178* ATF3_27146783_Chip-Seq_COLON_Human0.63221164
179ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62868547
180UTX_26944678_Chip-Seq_JUKART_Human0.62356950
181* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62269213
182CEBPB_22108803_ChIP-Seq_LS180_Human0.62103745
183SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61477535
184RARG_19884340_ChIP-ChIP_MEFs_Mouse0.60483084
185* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.59879355
186MYC_22102868_ChIP-Seq_BL_Human0.59722285
187CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58339971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.06333302
2MP0005360_urolithiasis6.66309727
3MP0005085_abnormal_gallbladder_physiolo5.75988241
4MP0005365_abnormal_bile_salt5.51076979
5MP0008875_abnormal_xenobiotic_pharmacok4.33175780
6MP0003806_abnormal_nucleotide_metabolis3.79437467
7MP0003252_abnormal_bile_duct3.74002667
8MP0009840_abnormal_foam_cell3.42566920
9MP0010329_abnormal_lipoprotein_level3.25423179
10MP0005083_abnormal_biliary_tract3.18385532
11MP0000569_abnormal_digit_pigmentation3.07600850
12MP0003763_abnormal_thymus_physiology2.67488363
13MP0002138_abnormal_hepatobiliary_system2.56884736
14MP0001666_abnormal_nutrient_absorption2.56784844
15MP0005332_abnormal_amino_acid2.39753711
16MP0003191_abnormal_cellular_cholesterol2.28126457
17MP0000609_abnormal_liver_physiology2.25149485
18MP0003195_calcinosis2.23699423
19MP0008877_abnormal_DNA_methylation2.21633792
20MP0003868_abnormal_feces_composition2.08389300
21MP0004019_abnormal_vitamin_homeostasis2.03507818
22MP0002118_abnormal_lipid_homeostasis2.03494321
23MP0001501_abnormal_sleep_pattern1.94590001
24MP0002148_abnormal_hypersensitivity_rea1.93363446
25MP0003787_abnormal_imprinting1.87211649
26MP0005319_abnormal_enzyme/_coenzyme1.87056613
27MP0002420_abnormal_adaptive_immunity1.86622814
28MP0001819_abnormal_immune_cell1.85227290
29MP0005310_abnormal_salivary_gland1.84223672
30MP0003656_abnormal_erythrocyte_physiolo1.80805268
31MP0001986_abnormal_taste_sensitivity1.76245187
32MP0005075_abnormal_melanosome_morpholog1.72775793
33MP0005174_abnormal_tail_pigmentation1.72654205
34MP0003646_muscle_fatigue1.72423897
35MP0000015_abnormal_ear_pigmentation1.66313760
36MP0005451_abnormal_body_composition1.63082230
37MP0008961_abnormal_basal_metabolism1.56205334
38MP0001764_abnormal_homeostasis1.52288688
39MP0003705_abnormal_hypodermis_morpholog1.49953254
40MP0002405_respiratory_system_inflammati1.48944657
41MP0005584_abnormal_enzyme/coenzyme_acti1.45930604
42MP0000716_abnormal_immune_system1.40787962
43MP0000689_abnormal_spleen_morphology1.37866369
44MP0005551_abnormal_eye_electrophysiolog1.37327774
45MP0002693_abnormal_pancreas_physiology1.36012539
46MP0003186_abnormal_redox_activity1.35001684
47MP0002277_abnormal_respiratory_mucosa1.34575314
48MP0008872_abnormal_physiological_respon1.34393310
49MP0003172_abnormal_lysosome_physiology1.34366782
50MP0002398_abnormal_bone_marrow1.34016442
51MP0009764_decreased_sensitivity_to1.33380795
52MP0002163_abnormal_gland_morphology1.32767530
53MP0002837_dystrophic_cardiac_calcinosis1.30772931
54MP0005670_abnormal_white_adipose1.30680597
55MP0004142_abnormal_muscle_tone1.29883283
56MP0009333_abnormal_splenocyte_physiolog1.27110566
57MP0009643_abnormal_urine_homeostasis1.26694668
58MP0004043_abnormal_pH_regulation1.24964162
59MP0002254_reproductive_system_inflammat1.23430352
60MP0000598_abnormal_liver_morphology1.22735478
61MP0003436_decreased_susceptibility_to1.22544370
62MP0008469_abnormal_protein_level1.21400961
63MP0002876_abnormal_thyroid_physiology1.18283714
64MP0002009_preneoplasia1.16572216
65MP0009763_increased_sensitivity_to1.15238866
66MP0009046_muscle_twitch1.14079992
67MP0000703_abnormal_thymus_morphology1.13530824
68MP0002933_joint_inflammation1.13389195
69MP0003866_abnormal_defecation1.11455446
70MP0000685_abnormal_immune_system1.10371413
71MP0000427_abnormal_hair_cycle1.09907020
72MP0005647_abnormal_sex_gland1.09541407
73MP0002722_abnormal_immune_system1.09173229
74MP0001533_abnormal_skeleton_physiology1.06885068
75MP0002971_abnormal_brown_adipose1.04776691
76MP0006082_CNS_inflammation1.03992688
77MP0003724_increased_susceptibility_to1.03016645
78MP0001919_abnormal_reproductive_system0.98962420
79MP0002429_abnormal_blood_cell0.96527653
80MP0005666_abnormal_adipose_tissue0.96377805
81MP0009745_abnormal_behavioral_response0.95935513
82MP0005379_endocrine/exocrine_gland_phen0.95925675
83MP0005646_abnormal_pituitary_gland0.95913079
84MP0001663_abnormal_digestive_system0.95645967
85MP0005334_abnormal_fat_pad0.95503884
86MP0002638_abnormal_pupillary_reflex0.94301263
87MP0001968_abnormal_touch/_nociception0.92332569
88MP0001502_abnormal_circadian_rhythm0.91501736
89MP0000371_diluted_coat_color0.91224435
90MP0002095_abnormal_skin_pigmentation0.90182337
91MP0001835_abnormal_antigen_presentation0.90118275
92MP0008995_early_reproductive_senescence0.89117417
93MP0009765_abnormal_xenobiotic_induced0.88653325
94MP0004742_abnormal_vestibular_system0.88475137
95MP0005636_abnormal_mineral_homeostasis0.87213223
96MP0004130_abnormal_muscle_cell0.87009005
97MP0009642_abnormal_blood_homeostasis0.85759925
98MP0000604_amyloidosis0.84865240
99MP0005464_abnormal_platelet_physiology0.84663453
100MP0002166_altered_tumor_susceptibility0.84251755
101MP0005645_abnormal_hypothalamus_physiol0.84073823
102MP0005025_abnormal_response_to0.83347797
103MP0000230_abnormal_systemic_arterial0.81109597
104MP0009785_altered_susceptibility_to0.80938704
105MP0001853_heart_inflammation0.80623022
106MP0005387_immune_system_phenotype0.80465731
107MP0001790_abnormal_immune_system0.80465731
108MP0001944_abnormal_pancreas_morphology0.80361658
109MP0003011_delayed_dark_adaptation0.79072588
110MP0010155_abnormal_intestine_physiology0.77822454
111MP0001845_abnormal_inflammatory_respons0.77619979
112MP0004924_abnormal_behavior0.77248975
113MP0005386_behavior/neurological_phenoty0.77248975
114MP0006036_abnormal_mitochondrial_physio0.77238474
115MP0005376_homeostasis/metabolism_phenot0.76883156
116MP0005389_reproductive_system_phenotype0.76257244
117MP0001800_abnormal_humoral_immune0.76242041
118MP0005058_abnormal_lysosome_morphology0.75682871
119MP0002653_abnormal_ependyma_morphology0.75474356
120MP0002078_abnormal_glucose_homeostasis0.75414133
121MP0005535_abnormal_body_temperature0.75033107
122MP0003075_altered_response_to0.74358465
123MP0003303_peritoneal_inflammation0.70916686
124MP0004947_skin_inflammation0.70394349
125MP0003300_gastrointestinal_ulcer0.70267785
126MP0004264_abnormal_extraembryonic_tissu0.69955481
127MP0003453_abnormal_keratinocyte_physiol0.68968531
128MP0002796_impaired_skin_barrier0.68418850
129MP0002419_abnormal_innate_immunity0.66582095
130MP0005266_abnormal_metabolism0.66549750
131MP0009115_abnormal_fat_cell0.66230759
132MP0010352_gastrointestinal_tract_polyps0.63560957
133MP0010368_abnormal_lymphatic_system0.62999785
134MP0004185_abnormal_adipocyte_glucose0.62772866
135MP0002136_abnormal_kidney_physiology0.59961191
136MP0005448_abnormal_energy_balance0.58522612
137MP0004510_myositis0.58144730
138MP0002723_abnormal_immune_serum0.57655622
139MP0005166_decreased_susceptibility_to0.56046718
140MP0009697_abnormal_copulation0.55977020
141MP0001545_abnormal_hematopoietic_system0.55837780
142MP0005397_hematopoietic_system_phenotyp0.55837780
143MP0003718_maternal_effect0.55087470
144MP0008874_decreased_physiological_sensi0.54973760
145MP0005084_abnormal_gallbladder_morpholo0.53676474
146MP0005220_abnormal_exocrine_pancreas0.51643259
147MP0008873_increased_physiological_sensi0.51553184
148MP0005395_other_phenotype0.51244312
149MP0002970_abnormal_white_adipose0.50609610
150MP0001873_stomach_inflammation0.49742657
151MP0005000_abnormal_immune_tolerance0.49585458
152MP0002928_abnormal_bile_duct0.48412486
153MP0003690_abnormal_glial_cell0.48381827
154MP0001756_abnormal_urination0.48021397
155MP0002452_abnormal_antigen_presenting0.47023468
156MP0005671_abnormal_response_to0.45795580
157MP0001881_abnormal_mammary_gland0.45021343
158MP0006035_abnormal_mitochondrial_morpho0.44388132
159MP0004381_abnormal_hair_follicle0.44160187

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.78671235
2Deep venous thrombosis (HP:0002625)6.57475791
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.46436601
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20303323
5Xanthomatosis (HP:0000991)5.89452244
6Prolonged partial thromboplastin time (HP:0003645)5.79184369
7Hypobetalipoproteinemia (HP:0003563)5.46697785
8Hyperlipoproteinemia (HP:0010980)5.34574127
9Complement deficiency (HP:0004431)5.10284983
10Joint hemorrhage (HP:0005261)4.48244989
11Hypolipoproteinemia (HP:0010981)4.24151935
12Stomatitis (HP:0010280)4.16389644
13Hyperammonemia (HP:0001987)4.12568773
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.10232744
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.00820905
16Hyperglycinemia (HP:0002154)3.97774965
17Abnormality of the common coagulation pathway (HP:0010990)3.94763857
18Hypoalphalipoproteinemia (HP:0003233)3.88787625
19Ketosis (HP:0001946)3.85217711
20Abnormality of complement system (HP:0005339)3.84338710
21Hyperglycinuria (HP:0003108)3.83755269
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83304914
23Epidermoid cyst (HP:0200040)3.80916554
24Fat malabsorption (HP:0002630)3.80596317
25Abnormality of methionine metabolism (HP:0010901)3.76595892
26Abnormality of serine family amino acid metabolism (HP:0010894)3.63982494
27Abnormality of glycine metabolism (HP:0010895)3.63982494
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61621623
29Myocardial infarction (HP:0001658)3.60358245
30Elevated erythrocyte sedimentation rate (HP:0003565)3.56595989
31Pancreatic cysts (HP:0001737)3.52773405
32Hypochromic microcytic anemia (HP:0004840)3.50630984
33Hypoglycemic coma (HP:0001325)3.50053941
34Congenital stationary night blindness (HP:0007642)3.49807199
35Hypercholesterolemia (HP:0003124)3.48130422
36Stomach cancer (HP:0012126)3.46373269
37Abnormality of pyrimidine metabolism (HP:0004353)3.39398817
38Genetic anticipation (HP:0003743)3.34839049
39Abnormality of the intrinsic pathway (HP:0010989)3.34240988
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.32466484
41Hyperventilation (HP:0002883)3.25474948
42Systemic lupus erythematosus (HP:0002725)3.12161148
43Recurrent gram-negative bacterial infections (HP:0005420)3.08457987
44Conjugated hyperbilirubinemia (HP:0002908)3.07197447
45IgG deficiency (HP:0004315)3.06886680
46Hyperbilirubinemia (HP:0002904)3.05811052
47Pancreatic fibrosis (HP:0100732)3.04546975
48Abnormality of fatty-acid metabolism (HP:0004359)3.00306034
49Large for gestational age (HP:0001520)2.95001687
50Abnormality of nucleobase metabolism (HP:0010932)2.93676271
51Molar tooth sign on MRI (HP:0002419)2.92645528
52Abnormality of midbrain morphology (HP:0002418)2.92645528
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.90809291
54Steatorrhea (HP:0002570)2.84284921
55Ketoacidosis (HP:0001993)2.84179566
56Spontaneous abortion (HP:0005268)2.83278308
57Abnormality of the renal cortex (HP:0011035)2.82609528
58Progressive cerebellar ataxia (HP:0002073)2.79752295
59Acanthocytosis (HP:0001927)2.75940730
60Recurrent fungal infections (HP:0002841)2.72196319
61Type II lissencephaly (HP:0007260)2.71943823
62True hermaphroditism (HP:0010459)2.71747442
63Abnormality of B cell number (HP:0010975)2.71071110
64Abnormality of purine metabolism (HP:0004352)2.70814997
65Abnormality of serum amino acid levels (HP:0003112)2.67556446
66Attenuation of retinal blood vessels (HP:0007843)2.67333282
67Abnormality of T cell physiology (HP:0011840)2.64844713
68Esophageal varix (HP:0002040)2.63903403
69Poikilocytosis (HP:0004447)2.61725621
70Panhypogammaglobulinemia (HP:0003139)2.60866865
71Gingival bleeding (HP:0000225)2.57971107
72Nephronophthisis (HP:0000090)2.57731862
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56167688
74Dicarboxylic aciduria (HP:0003215)2.56167688
75Abnormal rod and cone electroretinograms (HP:0008323)2.55750864
76Malnutrition (HP:0004395)2.55495863
77Albinism (HP:0001022)2.51993001
78Hepatocellular carcinoma (HP:0001402)2.51301075
79Delayed CNS myelination (HP:0002188)2.50857902
80Retrobulbar optic neuritis (HP:0100654)2.50662822
81Optic neuritis (HP:0100653)2.50662822
82Myositis (HP:0100614)2.49913282
83Abnormality of T cells (HP:0002843)2.49483860
84Fair hair (HP:0002286)2.49253481
85Gaze-evoked nystagmus (HP:0000640)2.48277377
86Hyperalaninemia (HP:0003348)2.46131563
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46131563
88Abnormality of alanine metabolism (HP:0010916)2.46131563
89Clumsiness (HP:0002312)2.44523236
90Vascular calcification (HP:0004934)2.44243476
91Metabolic acidosis (HP:0001942)2.43099474
92Chronic mucocutaneous candidiasis (HP:0002728)2.42113275
93Recurrent cutaneous fungal infections (HP:0011370)2.42113275
94Hemorrhage of the eye (HP:0011885)2.41102968
95Lethargy (HP:0001254)2.39718434
96Abnormality of T cell number (HP:0011839)2.39208686
97Glomerulonephritis (HP:0000099)2.38858456
98Skin nodule (HP:0200036)2.37586599
99Amyloidosis (HP:0011034)2.37563119
100Abnormality of the renal medulla (HP:0100957)2.37193252
101Abnormality of the prostate (HP:0008775)2.35564943
102Autoimmune hemolytic anemia (HP:0001890)2.35109123
103Cholelithiasis (HP:0001081)2.34180479
104Gout (HP:0001997)2.34004033
105Abnormal gallbladder morphology (HP:0012437)2.30992984
106Prostate neoplasm (HP:0100787)2.29217464
107Polycythemia (HP:0001901)2.28730846
108Febrile seizures (HP:0002373)2.28438089
109Polydipsia (HP:0001959)2.24733942
110Abnormal drinking behavior (HP:0030082)2.24733942
111Reticulocytosis (HP:0001923)2.23760202
112Medial flaring of the eyebrow (HP:0010747)2.23267414
113B lymphocytopenia (HP:0010976)2.22342026
114Severe combined immunodeficiency (HP:0004430)2.21702396
115Irritability (HP:0000737)2.21606352
116Alveolar cell carcinoma (HP:0006519)2.21537577
117Recurrent bronchitis (HP:0002837)2.21105364
118Autoimmune thrombocytopenia (HP:0001973)2.20982402
119Protruding tongue (HP:0010808)2.20146304
120Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19993002
121Menorrhagia (HP:0000132)2.19498953
122Abnormality of iron homeostasis (HP:0011031)2.19270460
123Pancreatitis (HP:0001733)2.19121634
124Abnormality of eosinophils (HP:0001879)2.18622465
125Spastic diplegia (HP:0001264)2.17567507
126Orchitis (HP:0100796)2.16446808
127T lymphocytopenia (HP:0005403)2.16439215
128Pulmonary infiltrates (HP:0002113)2.15641598
129Chronic hepatic failure (HP:0100626)2.14449864
130Hypochromic anemia (HP:0001931)2.14362034
131Thrombophlebitis (HP:0004418)2.13930380
132Vasculitis (HP:0002633)2.13518553
133Generalized hypopigmentation of hair (HP:0011358)2.13084390
134Cholecystitis (HP:0001082)2.12774471
135Abnormal gallbladder physiology (HP:0012438)2.12774471
136Eosinophilia (HP:0001880)2.10670715
137Abnormality of transition element cation homeostasis (HP:0011030)2.10338647
138Neoplasm of the tracheobronchial system (HP:0100552)2.10199035
139Absent/shortened dynein arms (HP:0200106)2.07799573
140Dynein arm defect of respiratory motile cilia (HP:0012255)2.07799573
141Cardiovascular calcification (HP:0011915)2.06726411
142Widely spaced teeth (HP:0000687)2.06007640
143Thyroiditis (HP:0100646)2.03150156
144Furrowed tongue (HP:0000221)2.02761593
145Neonatal onset (HP:0003623)2.01959742
146Mitral stenosis (HP:0001718)2.01719301
147Encephalitis (HP:0002383)2.01310047
148Increased serum ferritin (HP:0003281)1.99565721
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99491280
150Renal cortical cysts (HP:0000803)1.97972113
151Tubular atrophy (HP:0000092)1.97225490
152Late onset (HP:0003584)1.96384641
153Hypoglycemic seizures (HP:0002173)1.95911308
154Abolished electroretinogram (ERG) (HP:0000550)1.95809514
155Hemoptysis (HP:0002105)1.94823021
156Generalized aminoaciduria (HP:0002909)1.93847214
157Sensorimotor neuropathy (HP:0007141)1.93106686
158Inability to walk (HP:0002540)1.92166356
159Mediastinal lymphadenopathy (HP:0100721)1.91404315
160Vomiting (HP:0002013)1.90897368
161Hypertriglyceridemia (HP:0002155)1.89716749
162Brushfield spots (HP:0001088)1.88328787
163Pustule (HP:0200039)1.88097918
164Rickets (HP:0002748)1.87780153
165Abnormal enzyme/coenzyme activity (HP:0012379)1.87563707
166Nephritis (HP:0000123)1.87386795
167Hematochezia (HP:0002573)1.87329704
168Abnormality of the pons (HP:0007361)1.87313157
169Eczematoid dermatitis (HP:0000976)1.85964774
170Abnormality of the gallbladder (HP:0005264)1.85652454
171Nausea (HP:0002018)1.84550741
172Recurrent bacterial skin infections (HP:0005406)1.84492168
173Cystic liver disease (HP:0006706)1.84217799
174Leukocytosis (HP:0001974)1.83241071
175Hydroxyprolinuria (HP:0003080)1.83146610
176Abnormality of proline metabolism (HP:0010907)1.83146610
177Status epilepticus (HP:0002133)1.82691019
178Decreased circulating renin level (HP:0003351)1.80186980
179Cerebral edema (HP:0002181)1.80173642
180Epistaxis (HP:0000421)1.79822120
181Microcytic anemia (HP:0001935)1.79364599
182Abnormal cartilage morphology (HP:0002763)1.78581582
183Chronic diarrhea (HP:0002028)1.75501605
184Chronic otitis media (HP:0000389)1.75243522
185Severe visual impairment (HP:0001141)1.75156129
186Granulocytopenia (HP:0001913)1.74344259
187Keratoconjunctivitis (HP:0001096)1.74097150
188Recurrent skin infections (HP:0001581)1.72679202
189Hypoplastic iliac wings (HP:0002866)1.72509994
190Meningitis (HP:0001287)1.71957600
191Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71092320
192Decreased central vision (HP:0007663)1.69781209
193Parakeratosis (HP:0001036)1.69115484
194Polyuria (HP:0000103)1.66461470
195Progressive inability to walk (HP:0002505)1.65214178
196Absence seizures (HP:0002121)1.64960672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.79437413
2ERN14.74796605
3FGFR43.78017685
4TXK3.65182242
5BCKDK3.56523662
6TAOK33.53783861
7SIK13.03801020
8ADRBK22.74914721
9TYK22.51914138
10TRIB32.49769840
11ACVR1B2.30323187
12CAMKK22.12240888
13TBK12.08788282
14MAP4K12.02097612
15MAP3K141.93346191
16IRAK31.87002464
17BMPR1B1.82640859
18MAP3K101.79276208
19TEC1.77269747
20ITK1.76767183
21GRK61.76716603
22GRK11.72526207
23CDK121.71272258
24EPHB11.69525486
25TNK21.66579629
26MAPK111.59706360
27MAPK151.50656635
28ERBB41.50598165
29MAP3K111.48464206
30NUAK11.48442945
31JAK11.48127496
32PKN21.45165205
33IKBKE1.40643533
34MAP3K131.40601338
35CSK1.39598046
36MST1R1.37693642
37LATS11.37247302
38MAP2K31.36563955
39TLK11.34362105
40JAK21.32708369
41JAK31.32337973
42ZAK1.30752319
43MARK31.30546521
44CSF1R1.28036888
45MAP3K61.25094559
46WNK41.23761824
47SIK31.23582827
48NLK1.21251984
49PTK61.18608166
50ICK1.18205726
51OXSR11.16834642
52IRAK11.16077686
53PRKAA21.15963381
54ABL21.15823767
55BLK1.13186072
56IRAK41.12168677
57STK31.08499245
58TAOK11.05853413
59LCK1.03796350
60EPHA31.03002235
61FES1.02360397
62MAP3K31.02321363
63RIPK11.00297188
64PASK0.97903479
65IKBKB0.97079751
66STK160.95806430
67ADRBK10.91768536
68INSRR0.88778057
69MAP4K20.88583671
70SGK20.88320217
71NME20.88188886
72MAPK130.87835925
73LYN0.87063102
74DAPK20.86768046
75CDK60.86706163
76NEK90.85979902
77MST40.84036238
78DYRK1B0.82535690
79CAMK1D0.81090159
80MAP3K10.81012477
81MAP2K60.80731703
82CDK40.79936458
83PTK2B0.79078675
84PIK3CA0.78366938
85AKT30.77936273
86PAK30.77810313
87PIM10.77426627
88MAP3K70.76534930
89MAP2K40.75282283
90CAMKK10.74418716
91PINK10.73976537
92WNK30.73455176
93CHUK0.70755809
94PRKAA10.70096747
95BMX0.68783629
96MAPK40.68498232
97ZAP700.68342130
98CDK190.64841931
99FGFR30.64532341
100GRK70.64061558
101MAP2K20.63345506
102KIT0.63313167
103SIK20.62912169
104MTOR0.62673219
105STK100.60448084
106MAPK70.60276215
107TRPM70.60051474
108OBSCN0.59966757
109BMPR20.59479655
110MKNK20.59223194
111PRKD20.59127538
112GSK3A0.59118750
113HCK0.58887607
114PDPK10.57923857
115FLT30.57142585
116MAPKAPK30.55774270
117MATK0.55302706
118STK110.55231775
119IRAK20.53504849
120MAP3K50.51121419
121TIE10.51104952
122EPHA20.50752168
123KDR0.50631895
124TGFBR10.49977765
125SGK30.49845796
126PDK10.48196452
127PIM20.47538622
128CAMK40.47290611
129TNIK0.47012987
130STK40.46865574
131RPS6KA60.46568695
132MOS0.45193717
133RIPK40.44930173
134MAPK120.44843360
135HIPK20.44712072
136EGFR0.44476221
137TGFBR20.43030945
138PRKCH0.42939676
139BTK0.42238831
140PIK3CG0.41957626
141ERBB20.41794551
142PRKCQ0.41678085
143EEF2K0.41552555
144SYK0.39802052
145PRKCZ0.39755998
146PRKCE0.39344567
147MAP3K80.38673252
148CAMK1G0.38224672
149PRKCI0.37933771
150ABL10.37852696
151RPS6KB20.37242287
152SGK4940.36623052
153SGK2230.36623052
154RPS6KA50.34756714
155WNK10.34550706

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48632520
2Nitrogen metabolism_Homo sapiens_hsa009103.32743918
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31941149
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27345408
5Arginine biosynthesis_Homo sapiens_hsa002203.14925978
6Complement and coagulation cascades_Homo sapiens_hsa046102.78622791
7Tryptophan metabolism_Homo sapiens_hsa003802.64507875
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52189726
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49122864
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43914373
11Fatty acid degradation_Homo sapiens_hsa000712.43481147
12Graft-versus-host disease_Homo sapiens_hsa053322.27182602
13Allograft rejection_Homo sapiens_hsa053302.24444723
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24368838
15Phototransduction_Homo sapiens_hsa047442.20530172
16Staphylococcus aureus infection_Homo sapiens_hsa051502.18466633
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13683717
18Autoimmune thyroid disease_Homo sapiens_hsa053202.11397924
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10652467
20PPAR signaling pathway_Homo sapiens_hsa033202.06670836
21Peroxisome_Homo sapiens_hsa041462.04533204
22T cell receptor signaling pathway_Homo sapiens_hsa046602.00160020
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96614783
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93983444
25Type I diabetes mellitus_Homo sapiens_hsa049401.93235060
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93004221
27Asthma_Homo sapiens_hsa053101.87267764
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82236810
29Chemical carcinogenesis_Homo sapiens_hsa052041.82163649
30Histidine metabolism_Homo sapiens_hsa003401.80863668
31Caffeine metabolism_Homo sapiens_hsa002321.79084203
32Selenocompound metabolism_Homo sapiens_hsa004501.78301046
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76030514
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.75268261
35Propanoate metabolism_Homo sapiens_hsa006401.75024888
36Butanoate metabolism_Homo sapiens_hsa006501.73320526
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.72636501
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70752383
39Fatty acid metabolism_Homo sapiens_hsa012121.68823295
40beta-Alanine metabolism_Homo sapiens_hsa004101.64128521
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54622314
42Retinol metabolism_Homo sapiens_hsa008301.53255868
43ABC transporters_Homo sapiens_hsa020101.50369978
44Bile secretion_Homo sapiens_hsa049761.49840525
45Osteoclast differentiation_Homo sapiens_hsa043801.46285473
46Fat digestion and absorption_Homo sapiens_hsa049751.46079890
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45819666
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45476887
49Ether lipid metabolism_Homo sapiens_hsa005651.41814776
50Circadian rhythm_Homo sapiens_hsa047101.41143852
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40668062
52Folate biosynthesis_Homo sapiens_hsa007901.40642883
53Phenylalanine metabolism_Homo sapiens_hsa003601.36424067
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30531644
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30410797
56Starch and sucrose metabolism_Homo sapiens_hsa005001.29106061
57TNF signaling pathway_Homo sapiens_hsa046681.29097295
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29066325
59Sulfur relay system_Homo sapiens_hsa041221.27233366
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.27023764
61Vitamin B6 metabolism_Homo sapiens_hsa007501.26811806
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24494636
63Tyrosine metabolism_Homo sapiens_hsa003501.23867616
64Hematopoietic cell lineage_Homo sapiens_hsa046401.22430558
65Sulfur metabolism_Homo sapiens_hsa009201.20822455
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19439319
67Dorso-ventral axis formation_Homo sapiens_hsa043201.18737039
68Rheumatoid arthritis_Homo sapiens_hsa053231.17700337
69Pyruvate metabolism_Homo sapiens_hsa006201.15491373
70Biosynthesis of amino acids_Homo sapiens_hsa012301.10566078
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08746838
72Maturity onset diabetes of the young_Homo sapiens_hsa049501.07176225
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06715229
74Carbon metabolism_Homo sapiens_hsa012001.00331352
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98199124
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95772463
77Lysine degradation_Homo sapiens_hsa003100.95534579
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92838935
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.91933895
80Antigen processing and presentation_Homo sapiens_hsa046120.90432840
81Herpes simplex infection_Homo sapiens_hsa051680.88836995
82Arginine and proline metabolism_Homo sapiens_hsa003300.88250394
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86253795
84Glycerolipid metabolism_Homo sapiens_hsa005610.85678785
85Tuberculosis_Homo sapiens_hsa051520.84778916
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84756430
87Fatty acid biosynthesis_Homo sapiens_hsa000610.81126347
88Vitamin digestion and absorption_Homo sapiens_hsa049770.80967209
89Olfactory transduction_Homo sapiens_hsa047400.80245313
90Steroid biosynthesis_Homo sapiens_hsa001000.80092219
91Fatty acid elongation_Homo sapiens_hsa000620.77503755
92FoxO signaling pathway_Homo sapiens_hsa040680.77350487
93Pentose phosphate pathway_Homo sapiens_hsa000300.76110300
94Morphine addiction_Homo sapiens_hsa050320.72887494
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72474846
96Chemokine signaling pathway_Homo sapiens_hsa040620.72251933
97Basal transcription factors_Homo sapiens_hsa030220.70333788
98RNA polymerase_Homo sapiens_hsa030200.70249886
99Toxoplasmosis_Homo sapiens_hsa051450.69873648
100One carbon pool by folate_Homo sapiens_hsa006700.66822460
101MAPK signaling pathway_Homo sapiens_hsa040100.65526290
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63775214
103Type II diabetes mellitus_Homo sapiens_hsa049300.63266057
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62744955
105Homologous recombination_Homo sapiens_hsa034400.61171546
106Glutathione metabolism_Homo sapiens_hsa004800.59162904
107Protein export_Homo sapiens_hsa030600.57688948
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55504808
109Calcium signaling pathway_Homo sapiens_hsa040200.54107214
110RNA degradation_Homo sapiens_hsa030180.53056628
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.50900332
112Insulin secretion_Homo sapiens_hsa049110.50627142
113Linoleic acid metabolism_Homo sapiens_hsa005910.50589131
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50468015
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49820110
116Hepatitis B_Homo sapiens_hsa051610.48774427
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48697143
118Serotonergic synapse_Homo sapiens_hsa047260.48444433
119Ovarian steroidogenesis_Homo sapiens_hsa049130.48118830
120Insulin resistance_Homo sapiens_hsa049310.47887517
121Platelet activation_Homo sapiens_hsa046110.47333450
122Epstein-Barr virus infection_Homo sapiens_hsa051690.46174441
123Fructose and mannose metabolism_Homo sapiens_hsa000510.46155561
124Taste transduction_Homo sapiens_hsa047420.44269056
125Fanconi anemia pathway_Homo sapiens_hsa034600.42181683
126Galactose metabolism_Homo sapiens_hsa000520.39946375
127Metabolic pathways_Homo sapiens_hsa011000.39268684
128Prolactin signaling pathway_Homo sapiens_hsa049170.38232867
129Nicotine addiction_Homo sapiens_hsa050330.37511994
130Collecting duct acid secretion_Homo sapiens_hsa049660.37027891
131Oxytocin signaling pathway_Homo sapiens_hsa049210.36378017
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.36358742
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.35456923
134Prion diseases_Homo sapiens_hsa050200.35343381
135Lysosome_Homo sapiens_hsa041420.34523404
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26083332
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.18487140
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.15774084
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.15216114
140AMPK signaling pathway_Homo sapiens_hsa041520.12038910
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11685663
142Glucagon signaling pathway_Homo sapiens_hsa049220.10577650
143Hepatitis C_Homo sapiens_hsa051600.08879956
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06988142
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.06486602
146African trypanosomiasis_Homo sapiens_hsa051430.01246158
147Arachidonic acid metabolism_Homo sapiens_hsa005900.01190727
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.00920689
149Acute myeloid leukemia_Homo sapiens_hsa052210.00639114
150Primary immunodeficiency_Homo sapiens_hsa05340-0.0563410
151Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0468929
152Measles_Homo sapiens_hsa05162-0.0367339
153B cell receptor signaling pathway_Homo sapiens_hsa04662-0.0348795
154Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0330486
155Insulin signaling pathway_Homo sapiens_hsa04910-0.0234026
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0233350
157Influenza A_Homo sapiens_hsa05164-0.0217568
158Leishmaniasis_Homo sapiens_hsa05140-0.0152344
159Regulation of autophagy_Homo sapiens_hsa04140-0.0122266
160Legionellosis_Homo sapiens_hsa05134-0.0098986

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