ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indole-containing compound catabolic process (GO:0042436)	4.23520880
2	indolalkylamine catabolic process (GO:0046218)	4.23520880
3	tryptophan catabolic process (GO:0006569)	4.23520880
4	indolalkylamine metabolic process (GO:0006586)	4.17547807
5	regulation of memory T cell differentiation (GO:0043380)	4.14711751
6	behavioral response to nicotine (GO:0035095)	4.13485280
7	L-fucose catabolic process (GO:0042355)	4.04103612
8	fucose catabolic process (GO:0019317)	4.04103612
9	L-fucose metabolic process (GO:0042354)	4.04103612
10	tryptophan metabolic process (GO:0006568)	3.69958459
11	cellular ketone body metabolic process (GO:0046950)	3.64690429
12	kynurenine metabolic process (GO:0070189)	3.61836770
13	detection of light stimulus involved in visual perception (GO:0050908)	3.60341664
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.60341664
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.58442299
16	amine catabolic process (GO:0009310)	3.41925734
17	cellular biogenic amine catabolic process (GO:0042402)	3.41925734
18	protein K11-linked deubiquitination (GO:0035871)	3.27182843
19	cilium or flagellum-dependent cell motility (GO:0001539)	3.26212284
20	ketone body metabolic process (GO:1902224)	3.23336557
21	platelet dense granule organization (GO:0060155)	3.23128633
22	neural tube formation (GO:0001841)	3.16813093
23	thrombin receptor signaling pathway (GO:0070493)	3.16618281
24	sulfation (GO:0051923)	3.07959682
25	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.07860942
26	dopamine transport (GO:0015872)	3.05383467
27	signal peptide processing (GO:0006465)	3.02884272
28	piRNA metabolic process (GO:0034587)	3.02178808
29	indole-containing compound metabolic process (GO:0042430)	2.92190399
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.91560411
31	NAD biosynthetic process (GO:0009435)	2.87771165
32	negative regulation of response to food (GO:0032096)	2.87669807
33	negative regulation of appetite (GO:0032099)	2.87669807
34	photoreceptor cell maintenance (GO:0045494)	2.86984862
35	protein neddylation (GO:0045116)	2.86794085
36	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.86445713
37	axoneme assembly (GO:0035082)	2.86309344
38	negative regulation of mast cell activation (GO:0033004)	2.84088202
39	aromatic amino acid family catabolic process (GO:0009074)	2.83122771
40	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.82595921
41	benzene-containing compound metabolic process (GO:0042537)	2.82077847
42	establishment of protein localization to Golgi (GO:0072600)	2.80901703
43	multicellular organism reproduction (GO:0032504)	2.72415254
44	DNA methylation involved in gamete generation (GO:0043046)	2.72396194
45	DNA deamination (GO:0045006)	2.65820527
46	tachykinin receptor signaling pathway (GO:0007217)	2.63935711
47	negative regulation of heart rate (GO:0010459)	2.63107813
48	regulation of MHC class II biosynthetic process (GO:0045346)	2.62518696
49	positive regulation of cAMP-mediated signaling (GO:0043950)	2.61085742
50	adaptation of signaling pathway (GO:0023058)	2.60976917
51	interkinetic nuclear migration (GO:0022027)	2.59045297
52	protein K63-linked deubiquitination (GO:0070536)	2.58335926
53	neuronal action potential (GO:0019228)	2.56804217
54	thyroid hormone metabolic process (GO:0042403)	2.56200289
55	adenosine metabolic process (GO:0046085)	2.55378523
56	response to pheromone (GO:0019236)	2.53847350
57	retinal cone cell development (GO:0046549)	2.52151274
58	positive regulation of developmental pigmentation (GO:0048087)	2.50940613
59	reflex (GO:0060004)	2.50028298
60	reciprocal meiotic recombination (GO:0007131)	2.48089557
61	reciprocal DNA recombination (GO:0035825)	2.48089557
62	gamma-aminobutyric acid transport (GO:0015812)	2.46929082
63	rRNA catabolic process (GO:0016075)	2.44305035
64	regulation of establishment of cell polarity (GO:2000114)	2.44246942
65	regulation of B cell receptor signaling pathway (GO:0050855)	2.40925253
66	regulation of skeletal muscle contraction (GO:0014819)	2.39267872
67	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.38890321
68	rhodopsin mediated signaling pathway (GO:0016056)	2.38075272
69	xenobiotic catabolic process (GO:0042178)	2.37827719
70	positive regulation of granulocyte differentiation (GO:0030854)	2.37733668
71	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.37222656
72	epithelial cilium movement (GO:0003351)	2.36457290
73	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.36057495
74	auditory receptor cell stereocilium organization (GO:0060088)	2.35430017
75	positive regulation of defense response to virus by host (GO:0002230)	2.34383976
76	drug catabolic process (GO:0042737)	2.34168986
77	aromatic amino acid family metabolic process (GO:0009072)	2.34082992
78	behavioral response to ethanol (GO:0048149)	2.34031166
79	autophagic vacuole fusion (GO:0000046)	2.33357691
80	regulation of hippo signaling (GO:0035330)	2.32407127
81	regulation of cilium movement (GO:0003352)	2.31492307
82	endosome to melanosome transport (GO:0035646)	2.30666560
83	endosome to pigment granule transport (GO:0043485)	2.30666560
84	cilium movement (GO:0003341)	2.30586164
85	double-strand break repair via homologous recombination (GO:0000724)	2.27776654
86	parental behavior (GO:0060746)	2.27689678
87	regulation of transmission of nerve impulse (GO:0051969)	2.26494912
88	sperm motility (GO:0030317)	2.25328825
89	regulation of pigment cell differentiation (GO:0050932)	2.24871000
90	protein K48-linked deubiquitination (GO:0071108)	2.24731147
91	cilium morphogenesis (GO:0060271)	2.24604631
92	activated T cell proliferation (GO:0050798)	2.24569969
93	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.24547710
94	recombinational repair (GO:0000725)	2.24383185
95	cilium organization (GO:0044782)	2.23428553
96	regulation of female receptivity (GO:0045924)	2.23394113
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.22521151
98	protein prenylation (GO:0018342)	2.22414431
99	prenylation (GO:0097354)	2.22414431
100	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.21346144

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.32500264
2	VDR_22108803_ChIP-Seq_LS180_Human	3.02267365
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93739859
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80488657
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76852314
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56074594
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30319492
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.29793517
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.23521602
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18033728
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.11943856
12	EWS_26573619_Chip-Seq_HEK293_Human	2.07388836
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05786001
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.05046088
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.94809369
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92181298
17	P300_19829295_ChIP-Seq_ESCs_Human	1.91671212
18	FUS_26573619_Chip-Seq_HEK293_Human	1.80945159
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.76334375
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.73410129
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.73274780
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72831824
23	STAT3_23295773_ChIP-Seq_U87_Human	1.72238514
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69440115
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67634884
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.66236703
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63957205
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61963783
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.61859897
30	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61497018
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59767491
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58559431
33	TCF4_23295773_ChIP-Seq_U87_Human	1.51734770
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51443060
35	AR_25329375_ChIP-Seq_VCAP_Human	1.50668355
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44559509
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.44559509
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40502932
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38778621
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35785956
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35534043
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35534043
43	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34783850
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34714316
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.33571609
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.31596795
47	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.31292298
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31127404
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30733834
50	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.30051055
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29015523
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29015523
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28260232
54	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27871154
55	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.27624196
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26420455
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.25698156
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25433129
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24680510
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24340351
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24082320
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23827629
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.23811204
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22914699
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22021419
66	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.21520279
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20605449
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18782743
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18702486
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18702486
71	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18595339
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.18513619
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17152537
74	SCL_19346495_ChIP-Seq_HPC-7_Human	1.16858214
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16410579
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15618162
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14199975
78	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.14146523
79	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13671912
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13599528
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13264861
82	GATA3_26560356_Chip-Seq_TH2_Human	1.12869177
83	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.12748124
84	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.11917343
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11665541
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09882595
87	TP53_16413492_ChIP-PET_HCT116_Human	1.09872060
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09192303
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08448423
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.08415350
91	AR_20517297_ChIP-Seq_VCAP_Human	1.07518382
92	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.06899450
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05397624
94	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03004471
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01058462
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00695999
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00138677
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99706031
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98590933
100	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.97797085

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.77730529
2	MP0005464_abnormal_platelet_physiology	2.98244857
3	MP0003195_calcinosis	2.63940259
4	MP0001968_abnormal_touch/_nociception	2.62976217
5	MP0008877_abnormal_DNA_methylation	2.49996097
6	MP0002736_abnormal_nociception_after	2.35578866
7	MP0005551_abnormal_eye_electrophysiolog	2.29398386
8	MP0008872_abnormal_physiological_respon	2.18943089
9	MP0005646_abnormal_pituitary_gland	2.13575339
10	MP0002102_abnormal_ear_morphology	2.09138528
11	MP0005645_abnormal_hypothalamus_physiol	2.01057458
12	MP0001501_abnormal_sleep_pattern	2.00404132
13	MP0009046_muscle_twitch	1.97546799
14	MP0005174_abnormal_tail_pigmentation	1.97225293
15	MP0003646_muscle_fatigue	1.96289315
16	MP0002876_abnormal_thyroid_physiology	1.86222046
17	MP0001986_abnormal_taste_sensitivity	1.85839718
18	MP0010386_abnormal_urinary_bladder	1.76760639
19	MP0003724_increased_susceptibility_to	1.70555468
20	MP0004142_abnormal_muscle_tone	1.69016575
21	MP0004043_abnormal_pH_regulation	1.67446885
22	MP0005084_abnormal_gallbladder_morpholo	1.63230955
23	MP0000230_abnormal_systemic_arterial	1.62459313
24	MP0006276_abnormal_autonomic_nervous	1.56444784
25	MP0002837_dystrophic_cardiac_calcinosis	1.54507566
26	MP0002138_abnormal_hepatobiliary_system	1.51726883
27	MP0005410_abnormal_fertilization	1.51281987
28	MP0008875_abnormal_xenobiotic_pharmacok	1.49116639
29	MP0003787_abnormal_imprinting	1.48130270
30	MP0009745_abnormal_behavioral_response	1.44063627
31	MP0000372_irregular_coat_pigmentation	1.42512583
32	MP0004130_abnormal_muscle_cell	1.41821266
33	MP0000427_abnormal_hair_cycle	1.40090164
34	MP0000015_abnormal_ear_pigmentation	1.39561045
35	MP0002638_abnormal_pupillary_reflex	1.39280585
36	MP0003136_yellow_coat_color	1.38474924
37	MP0003252_abnormal_bile_duct	1.37523246
38	MP0005167_abnormal_blood-brain_barrier	1.36075484
39	MP0001835_abnormal_antigen_presentation	1.35442467
40	MP0002733_abnormal_thermal_nociception	1.35339274
41	MP0005253_abnormal_eye_physiology	1.32879726
42	MP0005671_abnormal_response_to	1.30075292
43	MP0001970_abnormal_pain_threshold	1.28571701
44	MP0010329_abnormal_lipoprotein_level	1.27815535
45	MP0004147_increased_porphyrin_level	1.27768415
46	MP0008004_abnormal_stomach_pH	1.26508525
47	MP0002735_abnormal_chemical_nociception	1.23636175
48	MP0008775_abnormal_heart_ventricle	1.20526619
49	MP0000383_abnormal_hair_follicle	1.18531248
50	MP0002272_abnormal_nervous_system	1.17813500
51	MP0006072_abnormal_retinal_apoptosis	1.17461155
52	MP0001984_abnormal_olfaction	1.16683226
53	MP0001486_abnormal_startle_reflex	1.15507437
54	MP0008057_abnormal_DNA_replication	1.15473840
55	MP0004215_abnormal_myocardial_fiber	1.12254994
56	MP0003718_maternal_effect	1.10197566
57	MP0009764_decreased_sensitivity_to	1.09339879
58	MP0002693_abnormal_pancreas_physiology	1.08911494
59	MP0005085_abnormal_gallbladder_physiolo	1.05810215
60	MP0001485_abnormal_pinna_reflex	1.04812667
61	MP0005075_abnormal_melanosome_morpholog	1.01638461
62	MP0005389_reproductive_system_phenotype	0.98646614
63	MP0002928_abnormal_bile_duct	0.98531145
64	MP0008961_abnormal_basal_metabolism	0.97798196
65	MP0001800_abnormal_humoral_immune	0.96683928
66	MP0003045_fibrosis	0.95276414
67	MP0005310_abnormal_salivary_gland	0.95214078
68	MP0005386_behavior/neurological_phenoty	0.94536911
69	MP0004924_abnormal_behavior	0.94536911
70	MP0000685_abnormal_immune_system	0.94328811
71	MP0002160_abnormal_reproductive_system	0.92434646
72	MP0002067_abnormal_sensory_capabilities	0.92191051
73	MP0002653_abnormal_ependyma_morphology	0.91793128
74	MP0002095_abnormal_skin_pigmentation	0.91761100
75	MP0002064_seizures	0.91332658
76	MP0001756_abnormal_urination	0.89838602
77	MP0002572_abnormal_emotion/affect_behav	0.89049692
78	MP0005647_abnormal_sex_gland	0.87386335
79	MP0005448_abnormal_energy_balance	0.87090922
80	MP0000631_abnormal_neuroendocrine_gland	0.86196053
81	MP0004084_abnormal_cardiac_muscle	0.85455771
82	MP0003950_abnormal_plasma_membrane	0.85157412
83	MP0003698_abnormal_male_reproductive	0.83000504
84	MP0001664_abnormal_digestion	0.82860125
85	MP0002148_abnormal_hypersensitivity_rea	0.82499135
86	MP0005083_abnormal_biliary_tract	0.81346979
87	MP0000465_gastrointestinal_hemorrhage	0.80639146
88	MP0005535_abnormal_body_temperature	0.79161234
89	MP0005266_abnormal_metabolism	0.78143028
90	MP0004484_altered_response_of	0.76377406
91	MP0006054_spinal_hemorrhage	0.76364143
92	MP0005332_abnormal_amino_acid	0.76244790
93	MP0003638_abnormal_response/metabolism_	0.75965810
94	MP0002723_abnormal_immune_serum	0.75202384
95	MP0001905_abnormal_dopamine_level	0.74250576
96	MP0001764_abnormal_homeostasis	0.72786854
97	MP0004085_abnormal_heartbeat	0.71381474
98	MP0001765_abnormal_ion_homeostasis	0.69938653
99	MP0001919_abnormal_reproductive_system	0.69396298
100	MP0000538_abnormal_urinary_bladder	0.69261125

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.47425672
2	Congenital stationary night blindness (HP:0007642)	4.04392369
3	Prolonged bleeding time (HP:0003010)	3.93554828
4	Pancreatic fibrosis (HP:0100732)	3.79194170
5	True hermaphroditism (HP:0010459)	3.68174356
6	Attenuation of retinal blood vessels (HP:0007843)	3.57699756
7	Molar tooth sign on MRI (HP:0002419)	3.49482736
8	Abnormality of midbrain morphology (HP:0002418)	3.49482736
9	Hyperventilation (HP:0002883)	3.45537611
10	Abnormality of the renal cortex (HP:0011035)	3.39960835
11	Gaze-evoked nystagmus (HP:0000640)	3.31120411
12	Nephronophthisis (HP:0000090)	3.16248295
13	Genetic anticipation (HP:0003743)	3.09995764
14	Progressive cerebellar ataxia (HP:0002073)	2.92628008
15	Abnormality of the renal medulla (HP:0100957)	2.89986015
16	Menorrhagia (HP:0000132)	2.86487823
17	Abolished electroretinogram (ERG) (HP:0000550)	2.84456876
18	Medial flaring of the eyebrow (HP:0010747)	2.81926885
19	Large for gestational age (HP:0001520)	2.79448242
20	Stomatitis (HP:0010280)	2.75050602
21	Febrile seizures (HP:0002373)	2.74197438
22	Decreased central vision (HP:0007663)	2.71428037
23	Clumsiness (HP:0002312)	2.67229025
24	Cystic liver disease (HP:0006706)	2.66358903
25	Petechiae (HP:0000967)	2.62359753
26	Type II lissencephaly (HP:0007260)	2.59725350
27	Abnormal drinking behavior (HP:0030082)	2.59386621
28	Polydipsia (HP:0001959)	2.59386621
29	Congenital sensorineural hearing impairment (HP:0008527)	2.57465446
30	Renal cortical cysts (HP:0000803)	2.56987641
31	Abnormality of alanine metabolism (HP:0010916)	2.54266272
32	Hyperalaninemia (HP:0003348)	2.54266272
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54266272
34	Epistaxis (HP:0000421)	2.48067341
35	Fair hair (HP:0002286)	2.45198866
36	Chronic hepatic failure (HP:0100626)	2.43433012
37	Inability to walk (HP:0002540)	2.42105807
38	Increased mean platelet volume (HP:0011877)	2.42067034
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.39944683
40	Tubular atrophy (HP:0000092)	2.39055503
41	Hypothermia (HP:0002045)	2.37322916
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.30270595
43	Hyperlipoproteinemia (HP:0010980)	2.28069535
44	Absent speech (HP:0001344)	2.27153145
45	Progressive inability to walk (HP:0002505)	2.22049340
46	Congenital hepatic fibrosis (HP:0002612)	2.22012668
47	Decreased circulating renin level (HP:0003351)	2.21826098
48	Abnormal platelet volume (HP:0011876)	2.21582180
49	Furrowed tongue (HP:0000221)	2.21127855
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21037758
51	Absent/shortened dynein arms (HP:0200106)	2.21037758
52	Protruding tongue (HP:0010808)	2.19580130
53	Gingival bleeding (HP:0000225)	2.15431193
54	Widely spaced teeth (HP:0000687)	2.13676264
55	Polyuria (HP:0000103)	2.11590710
56	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.10358566
57	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10184839
58	Bony spicule pigmentary retinopathy (HP:0007737)	2.09583188
59	Increased corneal curvature (HP:0100692)	2.08386151
60	Keratoconus (HP:0000563)	2.08386151
61	Ketoacidosis (HP:0001993)	2.08140352
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08018367
63	Abnormal ciliary motility (HP:0012262)	2.05211915
64	Male pseudohermaphroditism (HP:0000037)	2.03522676
65	Congenital primary aphakia (HP:0007707)	2.02947739
66	Gait imbalance (HP:0002141)	2.02932414
67	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97887133
68	Sclerocornea (HP:0000647)	1.97019646
69	Stomach cancer (HP:0012126)	1.95728185
70	Ketosis (HP:0001946)	1.93310472
71	Thyroid-stimulating hormone excess (HP:0002925)	1.92604984
72	Congenital, generalized hypertrichosis (HP:0004540)	1.91856393
73	Generalized hypopigmentation of hair (HP:0011358)	1.90456992
74	Nephrogenic diabetes insipidus (HP:0009806)	1.90431249
75	Dialeptic seizures (HP:0011146)	1.90349340
76	Lissencephaly (HP:0001339)	1.89594043
77	Bile duct proliferation (HP:0001408)	1.89051220
78	Abnormal biliary tract physiology (HP:0012439)	1.89051220
79	3-Methylglutaconic aciduria (HP:0003535)	1.81719511
80	Bulbous nose (HP:0000414)	1.81031063
81	Cerebellar dysplasia (HP:0007033)	1.79559525
82	Poikilocytosis (HP:0004447)	1.79327854
83	Dyschromatopsia (HP:0007641)	1.79059634
84	Purpura (HP:0000979)	1.77933642
85	Thyroiditis (HP:0100646)	1.77692076
86	Pendular nystagmus (HP:0012043)	1.76817424
87	Facial diplegia (HP:0001349)	1.75819034
88	Hypoplasia of the fovea (HP:0007750)	1.74866269
89	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.74866269
90	Albinism (HP:0001022)	1.74304427
91	Anencephaly (HP:0002323)	1.74135960
92	Hemiparesis (HP:0001269)	1.73742670
93	IgG deficiency (HP:0004315)	1.71999437
94	Tinnitus (HP:0000360)	1.70529122
95	Atonic seizures (HP:0010819)	1.68378822
96	Constricted visual fields (HP:0001133)	1.67758023
97	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.67315588
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.66709876
99	Abnormal respiratory epithelium morphology (HP:0012253)	1.66709876
100	Abnormal urine output (HP:0012590)	1.66236532

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.62067550
2	ADRBK2	3.17360977
3	ACVR1B	3.07792694
4	BMPR1B	3.00800370
5	TAOK3	2.88372694
6	MAP4K2	2.36480873
7	TXK	2.16856839
8	NUAK1	2.03928979
9	PINK1	2.01301030
10	TEC	1.93469183
11	GRK1	1.89601419
12	PIK3CG	1.83604795
13	ZAK	1.81940780
14	MST4	1.69698085
15	WNK3	1.57249166
16	MAPK13	1.56169658
17	PTK2B	1.54428023
18	TLK1	1.53874374
19	INSRR	1.52620110
20	ADRBK1	1.47250727
21	OXSR1	1.41151534
22	DAPK2	1.21137267
23	BTK	1.21087915
24	WNK4	1.18606311
25	MAPKAPK3	1.16285025
26	CASK	1.11491559
27	SYK	1.11018340
28	RIPK4	1.09022138
29	AKT3	1.07313183
30	IKBKB	1.06552162
31	TNK2	1.05266065
32	ITK	1.04830923
33	STK3	1.03818725
34	CAMKK2	0.97034582
35	STK39	0.96971224
36	NTRK3	0.95442482
37	MAP3K4	0.94905123
38	GRK5	0.94441875
39	BMPR2	0.92924700
40	TRPM7	0.91143581
41	MYLK	0.90861953
42	PAK3	0.89411332
43	MKNK2	0.89203236
44	PLK2	0.88578526
45	TNIK	0.87419803
46	TGFBR1	0.84571380
47	GRK7	0.82028528
48	PRKCE	0.81309868
49	STK38L	0.77233395
50	MAP4K1	0.73293318
51	CSF1R	0.69036657
52	IRAK1	0.68339287
53	KIT	0.65844700
54	MAP3K7	0.63577654
55	BLK	0.62470176
56	PIK3CA	0.61681518
57	PNCK	0.61497402
58	MAP2K6	0.60816106
59	GRK6	0.60681619
60	FLT3	0.59290261
61	MARK3	0.58727110
62	NLK	0.58147339
63	PRKCQ	0.57872193
64	LYN	0.56818655
65	PRKCG	0.56767944
66	FES	0.56256935
67	BRSK2	0.54775938
68	PKN1	0.54002629
69	TRIM28	0.53003668
70	FER	0.51032754
71	PRKAA2	0.50674694
72	HCK	0.50369976
73	BMX	0.50319261
74	MAPK15	0.48321445
75	TIE1	0.48183056
76	CAMK1	0.47353491
77	OBSCN	0.46862920
78	SGK2	0.44763596
79	MAP2K1	0.42202301
80	PHKG2	0.41410343
81	PHKG1	0.41410343
82	PRKG1	0.41107281
83	ERBB3	0.40979094
84	STK11	0.39768585
85	CAMK2A	0.39336399
86	ERBB2	0.39334807
87	PDK1	0.38220069
88	LCK	0.37727167
89	CHUK	0.36525242
90	PRKACA	0.35396271
91	MUSK	0.35194772
92	IGF1R	0.34255470
93	DYRK1A	0.33606008
94	EPHA3	0.31933387
95	ABL1	0.31783243
96	VRK1	0.30105161
97	FGFR2	0.29482411
98	CSNK1D	0.29300306
99	PRKCA	0.29281073
100	RPS6KA5	0.28913830

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	2.70185153
2	Phototransduction_Homo sapiens_hsa04744	2.69201514
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.61640346
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.61120890
5	Butanoate metabolism_Homo sapiens_hsa00650	2.39738350
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.08533932
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00179086
8	Platelet activation_Homo sapiens_hsa04611	1.94855185
9	Olfactory transduction_Homo sapiens_hsa04740	1.87869775
10	Tryptophan metabolism_Homo sapiens_hsa00380	1.78301812
11	ABC transporters_Homo sapiens_hsa02010	1.77942551
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.77164534
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77066549
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.68369670
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.68291344
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.63740304
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.60569315
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.58911431
19	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.58479133
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.56929770
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51258041
22	Serotonergic synapse_Homo sapiens_hsa04726	1.49745286
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.47012260
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.46551467
25	Asthma_Homo sapiens_hsa05310	1.45176086
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44483694
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.42686783
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42630806
29	Nicotine addiction_Homo sapiens_hsa05033	1.40382996
30	Morphine addiction_Homo sapiens_hsa05032	1.40210670
31	Taste transduction_Homo sapiens_hsa04742	1.37025682
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.35934782
33	Circadian entrainment_Homo sapiens_hsa04713	1.30952924
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25031672
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23413820
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.21512463
37	Homologous recombination_Homo sapiens_hsa03440	1.18947587
38	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.18696362
39	Graft-versus-host disease_Homo sapiens_hsa05332	1.18254729
40	Primary immunodeficiency_Homo sapiens_hsa05340	1.13857992
41	Regulation of autophagy_Homo sapiens_hsa04140	1.13439514
42	Calcium signaling pathway_Homo sapiens_hsa04020	1.09656720
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09622310
44	Basal transcription factors_Homo sapiens_hsa03022	1.09296309
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08935003
46	Salivary secretion_Homo sapiens_hsa04970	1.05595056
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.04681651
48	Type I diabetes mellitus_Homo sapiens_hsa04940	1.01449151
49	Retinol metabolism_Homo sapiens_hsa00830	0.98922759
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.98787418
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96232351
52	GABAergic synapse_Homo sapiens_hsa04727	0.95368388
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.95346094
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94446882
55	Caffeine metabolism_Homo sapiens_hsa00232	0.94396707
56	Allograft rejection_Homo sapiens_hsa05330	0.92755972
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92631745
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91357544
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.90182167
60	Circadian rhythm_Homo sapiens_hsa04710	0.90172273
61	Long-term depression_Homo sapiens_hsa04730	0.89354752
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84575968
63	Insulin secretion_Homo sapiens_hsa04911	0.79819242
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77980896
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77500465
66	Renin secretion_Homo sapiens_hsa04924	0.76367273
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.75950177
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75356303
69	Peroxisome_Homo sapiens_hsa04146	0.75239733
70	Propanoate metabolism_Homo sapiens_hsa00640	0.74005494
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.68385268
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67542188
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67029689
74	Cholinergic synapse_Homo sapiens_hsa04725	0.63446373
75	Pancreatic secretion_Homo sapiens_hsa04972	0.60158027
76	RNA polymerase_Homo sapiens_hsa03020	0.59775570
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59135416
78	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.57968723
79	One carbon pool by folate_Homo sapiens_hsa00670	0.56968170
80	Histidine metabolism_Homo sapiens_hsa00340	0.56117196
81	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.55766454
82	Sulfur metabolism_Homo sapiens_hsa00920	0.53988143
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53622660
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53566740
85	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.51699020
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.51453767
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50703553
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.49133559
89	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48781101
90	Purine metabolism_Homo sapiens_hsa00230	0.47266623
91	Gastric acid secretion_Homo sapiens_hsa04971	0.46252911
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45808560
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.41837682
94	RNA degradation_Homo sapiens_hsa03018	0.41814743
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.38040780
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36427805
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36280007
98	Chemokine signaling pathway_Homo sapiens_hsa04062	0.34023253
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.33420628
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.29840985

WHAMMP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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