WHSC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.40662329
2DNA unwinding involved in DNA replication (GO:0006268)4.76483878
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.74669238
4sister chromatid segregation (GO:0000819)4.44481747
5DNA strand elongation involved in DNA replication (GO:0006271)4.24799989
6DNA strand elongation (GO:0022616)4.15919267
7meiotic chromosome segregation (GO:0045132)4.12708410
8mitotic chromosome condensation (GO:0007076)4.09065669
9DNA replication initiation (GO:0006270)4.04870063
10nuclear pore complex assembly (GO:0051292)4.04203368
11pre-miRNA processing (GO:0031054)3.91298390
12heterochromatin organization (GO:0070828)3.84139119
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.81429122
14protein localization to kinetochore (GO:0034501)3.77641762
15regulation of DNA endoreduplication (GO:0032875)3.74708567
16nuclear pore organization (GO:0006999)3.70829900
17telomere maintenance via semi-conservative replication (GO:0032201)3.69545548
18mitotic sister chromatid segregation (GO:0000070)3.66837394
19DNA synthesis involved in DNA repair (GO:0000731)3.62934944
20regulation of sister chromatid cohesion (GO:0007063)3.59696419
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52994886
22layer formation in cerebral cortex (GO:0021819)3.52883751
23mRNA splice site selection (GO:0006376)3.50421323
24peptidyl-lysine dimethylation (GO:0018027)3.48985109
25mitotic nuclear envelope disassembly (GO:0007077)3.47127341
26mitotic metaphase plate congression (GO:0007080)3.45890972
27regulation of mitotic spindle organization (GO:0060236)3.43415699
28DNA topological change (GO:0006265)3.42725732
29negative regulation of histone methylation (GO:0031061)3.37384198
30regulation of RNA export from nucleus (GO:0046831)3.36577299
31microtubule depolymerization (GO:0007019)3.35780237
32nuclear envelope disassembly (GO:0051081)3.35240151
33membrane disassembly (GO:0030397)3.35240151
34kinetochore organization (GO:0051383)3.31884154
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31010582
36regulation of spindle organization (GO:0090224)3.30760553
37protein localization to chromosome, centromeric region (GO:0071459)3.27280057
38establishment of mitotic spindle localization (GO:0040001)3.26339574
39translesion synthesis (GO:0019985)3.25762700
40regulation of histone H3-K9 methylation (GO:0051570)3.23595315
41positive regulation of DNA-dependent DNA replication (GO:2000105)3.23389320
42regulation of centriole replication (GO:0046599)3.23151817
43mitotic recombination (GO:0006312)3.22645355
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21610978
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21610978
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.21610978
47establishment of nucleus localization (GO:0040023)3.19400827
48regulation of translational fidelity (GO:0006450)3.16695156
49negative regulation of RNA splicing (GO:0033119)3.16402316
50telomere maintenance via recombination (GO:0000722)3.14666908
51DNA replication checkpoint (GO:0000076)3.14450069
52cytoplasmic mRNA processing body assembly (GO:0033962)3.09694130
53establishment of spindle localization (GO:0051293)3.08761391
54metaphase plate congression (GO:0051310)3.08431660
55alternative mRNA splicing, via spliceosome (GO:0000380)3.07761152
56V(D)J recombination (GO:0033151)3.04654182
57chromosome condensation (GO:0030261)2.93834313
58negative regulation of DNA repair (GO:0045738)2.93463676
59DNA duplex unwinding (GO:0032508)2.93307343
60DNA geometric change (GO:0032392)2.93187855
61nucleosome disassembly (GO:0006337)2.92066590
62protein-DNA complex disassembly (GO:0032986)2.92066590
63pore complex assembly (GO:0046931)2.91785823
64nucleotide-excision repair, DNA gap filling (GO:0006297)2.89420147
65negative regulation of mRNA processing (GO:0050686)2.89246329
66spindle organization (GO:0007051)2.86576395
67positive regulation of RNA splicing (GO:0033120)2.85918104
68establishment of chromosome localization (GO:0051303)2.85888767
69glucocorticoid receptor signaling pathway (GO:0042921)2.84189737
70positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.82107545
71dosage compensation (GO:0007549)2.81942453
72regulation of chromosome segregation (GO:0051983)2.81408531
73chromatin assembly (GO:0031497)2.80022179
74double-strand break repair via nonhomologous end joining (GO:0006303)2.79776815
75non-recombinational repair (GO:0000726)2.79776815
76chromatin assembly or disassembly (GO:0006333)2.79653051
77DNA replication-dependent nucleosome assembly (GO:0006335)2.79245008
78DNA replication-dependent nucleosome organization (GO:0034723)2.79245008
79nuclear envelope organization (GO:0006998)2.78416428
80establishment of spindle orientation (GO:0051294)2.77958705
81paraxial mesoderm development (GO:0048339)2.77305594
82regulation of histone H3-K4 methylation (GO:0051569)2.77013075
83positive regulation of gene expression, epigenetic (GO:0045815)2.76981701
84positive regulation of cell cycle checkpoint (GO:1901978)2.75854061
85regulation of histone H3-K27 methylation (GO:0061085)2.75437528
86stress granule assembly (GO:0034063)2.73570512
87positive regulation of chromosome segregation (GO:0051984)2.73218759
88spindle assembly checkpoint (GO:0071173)2.73016657
89central nervous system projection neuron axonogenesis (GO:0021952)2.72568659
90regulation of histone methylation (GO:0031060)2.71795802
91DNA ligation (GO:0006266)2.71535906
92regulation of nucleobase-containing compound transport (GO:0032239)2.71478786
93positive regulation of dendritic spine morphogenesis (GO:0061003)2.69438371
94spindle assembly (GO:0051225)2.69132501
95axonal fasciculation (GO:0007413)2.68712642
96spindle checkpoint (GO:0031577)2.68470546
97peptidyl-arginine omega-N-methylation (GO:0035247)2.68293206
98peptidyl-arginine methylation (GO:0018216)2.68012032
99peptidyl-arginine N-methylation (GO:0035246)2.68012032
100regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67073849
101DNA packaging (GO:0006323)2.67018429
102negative regulation of mRNA metabolic process (GO:1903312)2.66797332
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66765108
104regulation of NFAT protein import into nucleus (GO:0051532)2.66120042
105chromosome segregation (GO:0007059)2.65282097
106spliceosomal tri-snRNP complex assembly (GO:0000244)2.65256559
107regulation of mitotic sister chromatid segregation (GO:0033047)2.65102822
108regulation of sister chromatid segregation (GO:0033045)2.65102822
109regulation of mitotic sister chromatid separation (GO:0010965)2.65102822
110chromosome organization (GO:0051276)2.64902310
111ATP-dependent chromatin remodeling (GO:0043044)2.64096860
112protein localization to chromosome (GO:0034502)2.64069739
113regulation of centrosome duplication (GO:0010824)2.62928341
114dendritic spine morphogenesis (GO:0060997)2.61718355
115establishment of mitotic spindle orientation (GO:0000132)2.61049660
116RNA stabilization (GO:0043489)2.60665944
117mRNA stabilization (GO:0048255)2.60665944
118establishment of integrated proviral latency (GO:0075713)2.60114360
119monoubiquitinated protein deubiquitination (GO:0035520)2.59894551
120mitotic cytokinesis (GO:0000281)2.59821086
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59752975
122sister chromatid cohesion (GO:0007062)2.59456578
123histone H3-K9 methylation (GO:0051567)2.58978053
124regulation of double-strand break repair (GO:2000779)2.58378603
125DNA conformation change (GO:0071103)2.57688448
126nucleosome organization (GO:0034728)2.57575879
127cell migration in hindbrain (GO:0021535)2.56031843
128mitotic spindle assembly checkpoint (GO:0007094)2.55604425
129mRNA transport (GO:0051028)2.55549557
130regulation of DNA damage checkpoint (GO:2000001)2.55436572
131attachment of spindle microtubules to kinetochore (GO:0008608)2.54704640
132DNA replication-independent nucleosome assembly (GO:0006336)2.53352320
133DNA replication-independent nucleosome organization (GO:0034724)2.53352320
134nucleus localization (GO:0051647)2.52962933
135negative regulation of chromosome segregation (GO:0051985)2.52206164
136regulation of centrosome cycle (GO:0046605)2.51593509
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.51105258
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.51105258
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.51105258
140negative regulation of sister chromatid segregation (GO:0033046)2.51105258
141regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.50748988
142mitotic spindle checkpoint (GO:0071174)2.49481148
143negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.49265936
144resolution of meiotic recombination intermediates (GO:0000712)2.48535902
145positive regulation of histone H3-K4 methylation (GO:0051571)2.47907089
146postreplication repair (GO:0006301)2.46594617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.28707850
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.19552119
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90880575
4EZH2_22144423_ChIP-Seq_EOC_Human3.51867276
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25442934
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.92570037
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.86952779
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.83352247
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.78821913
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.75990131
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.60064801
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49317736
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39382001
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35974019
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26597936
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.10031572
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06376907
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.02790431
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01179426
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00230604
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99992036
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76233869
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74731764
24* TP63_19390658_ChIP-ChIP_HaCaT_Human1.71467333
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69674322
26MYC_22102868_ChIP-Seq_BL_Human1.68736382
27* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65565701
28ZNF274_21170338_ChIP-Seq_K562_Hela1.65035794
29XRN2_22483619_ChIP-Seq_HELA_Human1.64175473
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59595868
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55934307
32EWS_26573619_Chip-Seq_HEK293_Human1.55830255
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55400132
34FUS_26573619_Chip-Seq_HEK293_Human1.53915899
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52315389
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51809608
37* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50326734
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50075125
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48313953
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47318498
41IGF1R_20145208_ChIP-Seq_DFB_Human1.46864364
42AR_21909140_ChIP-Seq_LNCAP_Human1.44463870
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44243344
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44034608
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42950368
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41538900
47GBX2_23144817_ChIP-Seq_PC3_Human1.41174684
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36527390
49KDM5A_27292631_Chip-Seq_BREAST_Human1.34142220
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33429754
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30823226
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29438274
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29071725
54* TTF2_22483619_ChIP-Seq_HELA_Human1.28971885
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28829071
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28423658
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26472435
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25081388
59VDR_21846776_ChIP-Seq_THP-1_Human1.24897155
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24415773
61CIITA_25753668_ChIP-Seq_RAJI_Human1.24163074
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23818801
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.18091932
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18013398
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17319259
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16928051
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.16709108
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16290777
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15433071
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14247332
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.12685090
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12102097
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11504325
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10770850
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09278338
76* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09267742
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.08864032
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07371067
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06692159
80SOX9_26525672_Chip-Seq_HEART_Mouse1.06198481
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05907873
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04538015
83CHD1_26751641_Chip-Seq_LNCaP_Human1.04446486
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.04176649
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04096361
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.03578555
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03306914
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01859761
89TCF7_22412390_ChIP-Seq_EML_Mouse1.01547794
90REST_21632747_ChIP-Seq_MESCs_Mouse1.01020977
91P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99568673
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98989499
93WT1_19549856_ChIP-ChIP_CCG9911_Human0.97852492
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97796694
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97409200
96RING1B_27294783_Chip-Seq_NPCs_Mouse0.97125099
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96999630
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96494079
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96494079
100KDM2B_26808549_Chip-Seq_K562_Human0.96098885
101RNF2_27304074_Chip-Seq_ESCs_Mouse0.95473199
102TP53_16413492_ChIP-PET_HCT116_Human0.93088295
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92771533
104AR_21572438_ChIP-Seq_LNCaP_Human0.92649510
105RNF2_27304074_Chip-Seq_NSC_Mouse0.91658302
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91438541
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.91045950
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90947206
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.90165320
110DROSHA_22980978_ChIP-Seq_HELA_Human0.89303468
111KDM2B_26808549_Chip-Seq_DND41_Human0.87170406
112ZNF263_19887448_ChIP-Seq_K562_Human0.86810108
113AR_19668381_ChIP-Seq_PC3_Human0.86440075
114DCP1A_22483619_ChIP-Seq_HELA_Human0.85268845
115* STAT3_23295773_ChIP-Seq_U87_Human0.85215747
116SMAD4_21799915_ChIP-Seq_A2780_Human0.85036132
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84880611
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84677688
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83876287
120TCF4_23295773_ChIP-Seq_U87_Human0.83339561
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82975989
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82800021
123MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82680315
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82339217
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82176168
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81614561
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.81508251
128GATA1_26923725_Chip-Seq_HPCs_Mouse0.79599769
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79449773
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.76912286
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76707406
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76620190
133CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76162273
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76014523
135POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.75235679
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75070653
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74950680
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74860750
139GABP_19822575_ChIP-Seq_HepG2_Human0.74622710
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74445702
141KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73739914
142ELK3_25401928_ChIP-Seq_HUVEC_Human0.73093027
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.72739662
144EZH2_18974828_ChIP-Seq_MESCs_Mouse0.72739662
145TAF15_26573619_Chip-Seq_HEK293_Human0.72703555
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.71834633
147* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.70310917
148E2F1_18555785_ChIP-Seq_MESCs_Mouse0.68798904
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.67974042
150NCOR1_26117541_ChIP-Seq_K562_Human0.67542663
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66621739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.97219156
2MP0003121_genomic_imprinting2.97008501
3MP0003787_abnormal_imprinting2.73747220
4MP0010094_abnormal_chromosome_stability2.72555610
5MP0003123_paternal_imprinting2.23041737
6MP0003122_maternal_imprinting2.22306388
7MP0003111_abnormal_nucleus_morphology2.22059628
8MP0000537_abnormal_urethra_morphology2.20418070
9MP0004859_abnormal_synaptic_plasticity2.17113812
10MP0008877_abnormal_DNA_methylation2.13056298
11MP0005076_abnormal_cell_differentiation2.03091354
12MP0003890_abnormal_embryonic-extraembry2.02978851
13MP0000778_abnormal_nervous_system2.00534556
14MP0000566_synostosis2.00034592
15MP0002009_preneoplasia1.81849675
16MP0003077_abnormal_cell_cycle1.75481453
17MP0008057_abnormal_DNA_replication1.74185066
18MP0005187_abnormal_penis_morphology1.66684246
19MP0003861_abnormal_nervous_system1.59929177
20MP0002877_abnormal_melanocyte_morpholog1.59012406
21MP0010307_abnormal_tumor_latency1.52902902
22MP0004185_abnormal_adipocyte_glucose1.47217777
23MP0004197_abnormal_fetal_growth/weight/1.47167830
24MP0006292_abnormal_olfactory_placode1.46228523
25MP0000631_abnormal_neuroendocrine_gland1.44631739
26MP0003635_abnormal_synaptic_transmissio1.43998348
27MP0002084_abnormal_developmental_patter1.42468004
28MP0001299_abnormal_eye_distance/1.40434150
29MP0001346_abnormal_lacrimal_gland1.40174388
30MP0002184_abnormal_innervation1.36774320
31MP0004811_abnormal_neuron_physiology1.34688737
32MP0001730_embryonic_growth_arrest1.33584932
33MP0002063_abnormal_learning/memory/cond1.33093438
34MP0000350_abnormal_cell_proliferation1.33057308
35MP0010352_gastrointestinal_tract_polyps1.31464149
36MP0003937_abnormal_limbs/digits/tail_de1.30810107
37MP0005409_darkened_coat_color1.30071399
38MP0003935_abnormal_craniofacial_develop1.28730239
39MP0004808_abnormal_hematopoietic_stem1.28277531
40MP0002085_abnormal_embryonic_tissue1.27179565
41MP0002249_abnormal_larynx_morphology1.26488791
42MP0003385_abnormal_body_wall1.26436104
43MP0003115_abnormal_respiratory_system1.26054854
44MP0001286_abnormal_eye_development1.25770089
45MP0004957_abnormal_blastocyst_morpholog1.25086442
46MP0010030_abnormal_orbit_morphology1.23959568
47MP0009703_decreased_birth_body1.23463058
48MP0003567_abnormal_fetal_cardiomyocyte1.21705566
49MP0002152_abnormal_brain_morphology1.21156854
50MP0005423_abnormal_somatic_nervous1.19505972
51MP0000015_abnormal_ear_pigmentation1.16990689
52MP0003119_abnormal_digestive_system1.16313247
53MP0008007_abnormal_cellular_replicative1.16254455
54MP0009278_abnormal_bone_marrow1.16108441
55MP0001672_abnormal_embryogenesis/_devel1.15850772
56MP0005380_embryogenesis_phenotype1.15850772
57MP0002751_abnormal_autonomic_nervous1.14163987
58MP0000534_abnormal_ureter_morphology1.13289507
59* MP0001697_abnormal_embryo_size1.12108946
60MP0004270_analgesia1.10519567
61MP0005174_abnormal_tail_pigmentation1.08508658
62MP0003984_embryonic_growth_retardation1.08012886
63MP0002088_abnormal_embryonic_growth/wei1.07469410
64MP0002081_perinatal_lethality1.07441633
65MP0008932_abnormal_embryonic_tissue1.07220173
66MP0003693_abnormal_embryo_hatching1.07203838
67MP0001348_abnormal_lacrimal_gland1.06767641
68MP0000955_abnormal_spinal_cord1.06668381
69MP0009672_abnormal_birth_weight1.06387791
70MP0005248_abnormal_Harderian_gland1.05586595
71MP0000428_abnormal_craniofacial_morphol1.04290179
72MP0009697_abnormal_copulation1.00858985
73MP0003880_abnormal_central_pattern1.00777424
74MP0000313_abnormal_cell_death0.99554596
75MP0008058_abnormal_DNA_repair0.99485494
76MP0002557_abnormal_social/conspecific_i0.99057195
77MP0002095_abnormal_skin_pigmentation0.98917529
78MP0001849_ear_inflammation0.98815670
79MP0002086_abnormal_extraembryonic_tissu0.98088306
80MP0009780_abnormal_chondrocyte_physiolo0.97081887
81* MP0003755_abnormal_palate_morphology0.96996038
82MP0002089_abnormal_postnatal_growth/wei0.96952925
83MP0008789_abnormal_olfactory_epithelium0.95971177
84MP0002697_abnormal_eye_size0.95444401
85MP0000733_abnormal_muscle_development0.95077682
86MP0001929_abnormal_gametogenesis0.94593658
87* MP0002116_abnormal_craniofacial_bone0.94010227
88MP0004233_abnormal_muscle_weight0.94009893
89MP0004924_abnormal_behavior0.93507286
90MP0005386_behavior/neurological_phenoty0.93507286
91MP0002111_abnormal_tail_morphology0.92554461
92MP0002080_prenatal_lethality0.92429034
93MP0002938_white_spotting0.92291117
94MP0005499_abnormal_olfactory_system0.91821627
95MP0005394_taste/olfaction_phenotype0.91821627
96MP0002572_abnormal_emotion/affect_behav0.91653906
97MP0003942_abnormal_urinary_system0.91407448
98MP0003705_abnormal_hypodermis_morpholog0.90803954
99MP0002234_abnormal_pharynx_morphology0.90709967
100MP0003943_abnormal_hepatobiliary_system0.89630341
101MP0001293_anophthalmia0.89598556
102MP0005257_abnormal_intraocular_pressure0.88527597
103MP0002102_abnormal_ear_morphology0.88439862
104MP0003283_abnormal_digestive_organ0.87965489
105MP0000432_abnormal_head_morphology0.87750420
106MP0002882_abnormal_neuron_morphology0.86613338
107MP0000049_abnormal_middle_ear0.85931441
108MP0003718_maternal_effect0.85588059
109MP0009053_abnormal_anal_canal0.84145757
110MP0005623_abnormal_meninges_morphology0.83650523
111MP0001145_abnormal_male_reproductive0.82993834
112MP0002233_abnormal_nose_morphology0.82588252
113MP0003315_abnormal_perineum_morphology0.82542211
114* MP0002114_abnormal_axial_skeleton0.82519507
115MP0009745_abnormal_behavioral_response0.82375920
116MP0010678_abnormal_skin_adnexa0.81588922
117MP0002396_abnormal_hematopoietic_system0.80906864
118MP0002210_abnormal_sex_determination0.80710108
119MP0008770_decreased_survivor_rate0.79576927
120MP0002092_abnormal_eye_morphology0.79182742
121MP0003938_abnormal_ear_development0.78658236
122MP0003698_abnormal_male_reproductive0.78338476
123MP0002067_abnormal_sensory_capabilities0.77775127
124MP0003699_abnormal_female_reproductive0.74328977
125MP0002161_abnormal_fertility/fecundity0.71698712
126MP0000653_abnormal_sex_gland0.71423124
127MP0005621_abnormal_cell_physiology0.70948402
128MP0000762_abnormal_tongue_morphology0.68369108
129MP0010234_abnormal_vibrissa_follicle0.67018400

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.85822343
2Short 4th metacarpal (HP:0010044)3.76614574
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.76614574
4Increased nuchal translucency (HP:0010880)3.16997906
5Hyperacusis (HP:0010780)3.13255096
6Macroorchidism (HP:0000053)2.91031922
7Elfin facies (HP:0004428)2.75049705
8Obsessive-compulsive behavior (HP:0000722)2.74282772
9Renal duplication (HP:0000075)2.73185066
10Abnormality of the 4th metacarpal (HP:0010012)2.71668661
11Renovascular hypertension (HP:0100817)2.68467653
12Overriding aorta (HP:0002623)2.56106883
13Heterotopia (HP:0002282)2.55400387
14Aqueductal stenosis (HP:0002410)2.53839649
15Cortical dysplasia (HP:0002539)2.50782659
16Abnormality of the astrocytes (HP:0100707)2.46535309
17Astrocytoma (HP:0009592)2.46535309
18Inappropriate behavior (HP:0000719)2.41589961
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.39741792
20Pointed chin (HP:0000307)2.39272464
21Meckel diverticulum (HP:0002245)2.38033020
22Termporal pattern (HP:0011008)2.35944249
23Insidious onset (HP:0003587)2.35944249
24Abnormality of the fingertips (HP:0001211)2.35119057
25Absent frontal sinuses (HP:0002688)2.34407399
26Subacute progressive viral hepatitis (HP:0006572)2.33817219
27Shoulder girdle muscle weakness (HP:0003547)2.29436857
28Abnormality of the ileum (HP:0001549)2.26549022
29Colon cancer (HP:0003003)2.25070024
30Insomnia (HP:0100785)2.24870094
31Birth length less than 3rd percentile (HP:0003561)2.22497140
32Duplication of thumb phalanx (HP:0009942)2.18847008
3311 pairs of ribs (HP:0000878)2.16761010
34Missing ribs (HP:0000921)2.15707629
35Trigonocephaly (HP:0000243)2.13766676
36Abnormality of chromosome segregation (HP:0002916)2.12883402
37Facial hemangioma (HP:0000329)2.11567718
38Deep palmar crease (HP:0006191)2.10316194
39* High anterior hairline (HP:0009890)2.09065150
40Abnormality of the calcaneus (HP:0008364)2.08814874
41Patellar aplasia (HP:0006443)2.08001068
42Vertebral arch anomaly (HP:0008438)2.07850946
43Sandal gap (HP:0001852)2.07193525
44Abnormality of the preputium (HP:0100587)2.06909833
45Urethral obstruction (HP:0000796)2.04513147
46Pelvic girdle muscle weakness (HP:0003749)2.04416056
47Asymmetry of the thorax (HP:0001555)2.03781769
48Ankyloglossia (HP:0010296)2.02319514
49Overlapping toe (HP:0001845)2.01561449
50Amyotrophic lateral sclerosis (HP:0007354)2.01452925
51Absent radius (HP:0003974)2.00863941
52Broad distal phalanx of finger (HP:0009836)2.00331458
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.00130559
54* Sacral dimple (HP:0000960)1.98888334
55Reticulocytopenia (HP:0001896)1.98732476
56Ulnar bowing (HP:0003031)1.97225623
57Small intestinal stenosis (HP:0012848)1.97085345
58Duodenal stenosis (HP:0100867)1.97085345
59Medulloblastoma (HP:0002885)1.97053159
60Papillary thyroid carcinoma (HP:0002895)1.96685159
61Excessive salivation (HP:0003781)1.96347123
62Drooling (HP:0002307)1.96347123
63Flat cornea (HP:0007720)1.96328034
64Abnormality of the phalanges of the hallux (HP:0010057)1.95716625
65Proximal placement of thumb (HP:0009623)1.94431809
66Glioma (HP:0009733)1.94042237
67Midline defect of the nose (HP:0004122)1.93677017
68Bowel diverticulosis (HP:0005222)1.93073969
69Abnormality of the musculature of the pelvis (HP:0001469)1.92808096
70Abnormality of the hip-girdle musculature (HP:0001445)1.92808096
71Truncal obesity (HP:0001956)1.92122313
72Abnormality of cochlea (HP:0000375)1.92115813
73Abnormality of oral frenula (HP:0000190)1.88294788
74Aplasia/Hypoplasia of the patella (HP:0006498)1.87779079
75Papilledema (HP:0001085)1.86859437
76Aplasia involving forearm bones (HP:0009822)1.86126574
77Absent forearm bone (HP:0003953)1.86126574
78Deviation of the thumb (HP:0009603)1.85025223
79Atresia of the external auditory canal (HP:0000413)1.84457540
80Ependymoma (HP:0002888)1.84071288
81Disinhibition (HP:0000734)1.83743064
82Transitional cell carcinoma of the bladder (HP:0006740)1.82657369
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.82390454
84Abnormality of the carotid arteries (HP:0005344)1.82052687
85Neoplasm of the adrenal cortex (HP:0100641)1.81165034
86Abnormality of the diencephalon (HP:0010662)1.79962728
87Ectopic kidney (HP:0000086)1.78950373
88Abnormality of the labia minora (HP:0012880)1.78687619
89Cutis marmorata (HP:0000965)1.77437052
90Oligodactyly (hands) (HP:0001180)1.77336541
91Spina bifida occulta (HP:0003298)1.77294106
92Narrow palate (HP:0000189)1.76752001
93Limited elbow extension (HP:0001377)1.76008890
94Broad face (HP:0000283)1.75095419
95Chromsome breakage (HP:0040012)1.74980055
96Large earlobe (HP:0009748)1.74517911
97Abnormality of the lower motor neuron (HP:0002366)1.73496011
98Short thumb (HP:0009778)1.73410807
99Arteriovenous malformation (HP:0100026)1.70611371
100Dysmetric saccades (HP:0000641)1.70269610
101Oligodactyly (HP:0012165)1.70266886
102Long palpebral fissure (HP:0000637)1.70245127
103Myelodysplasia (HP:0002863)1.70186042
104Tented upper lip vermilion (HP:0010804)1.69930824
105Deep philtrum (HP:0002002)1.69656529
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69519696
107Abnormality of the duodenum (HP:0002246)1.69398464
108Attention deficit hyperactivity disorder (HP:0007018)1.69212847
109Urinary urgency (HP:0000012)1.69204323
110Broad thumb (HP:0011304)1.69010786
111Uterine leiomyosarcoma (HP:0002891)1.68182640
112Leiomyosarcoma (HP:0100243)1.68182640
113Abnormal number of incisors (HP:0011064)1.68095384
114Shallow orbits (HP:0000586)1.68036322
115Acute lymphatic leukemia (HP:0006721)1.67715119
116Breast hypoplasia (HP:0003187)1.67570202
117Bladder neoplasm (HP:0009725)1.67346111
118Bladder carcinoma (HP:0002862)1.67346111
119Hepatoblastoma (HP:0002884)1.66377753
120Hypopigmentation of the fundus (HP:0007894)1.65391735
121Thick eyebrow (HP:0000574)1.64920134
122Capillary hemangiomas (HP:0005306)1.64311500
123Abnormality of DNA repair (HP:0003254)1.63326282
124Vesicoureteral reflux (HP:0000076)1.63150795
125Patellar dislocation (HP:0002999)1.62485970
126Protruding tongue (HP:0010808)1.61907943
127Embryonal neoplasm (HP:0002898)1.61412139
128Hypoplasia of the maxilla (HP:0000327)1.60522867
129Smooth philtrum (HP:0000319)1.60315118
130Broad palm (HP:0001169)1.59417918
131Broad phalanges of the hand (HP:0009768)1.58923508
132Increased density of long bones (HP:0006392)1.58876435
133Long eyelashes (HP:0000527)1.58001383
134Nephroblastoma (Wilms tumor) (HP:0002667)1.57744292
135Flat acetabular roof (HP:0003180)1.57457403
136Abnormality of chromosome stability (HP:0003220)1.57357966
137Pseudobulbar signs (HP:0002200)1.56202985
138Broad finger (HP:0001500)1.55928593
139Malignant gastrointestinal tract tumors (HP:0006749)1.55738717
140Gastrointestinal carcinoma (HP:0002672)1.55738717
141Relative macrocephaly (HP:0004482)1.55735326
142Autism (HP:0000717)1.55657865
143Cafe-au-lait spot (HP:0000957)1.54506325
144Flared metaphyses (HP:0003015)1.54480152
145Embryonal renal neoplasm (HP:0011794)1.54220720
146Thin upper lip vermilion (HP:0000219)1.54140560
147Impulsivity (HP:0100710)1.53486530
148Impaired vibration sensation in the lower limbs (HP:0002166)1.53088045
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.52985760
150Choanal atresia (HP:0000453)1.52500119
151Enlarged penis (HP:0000040)1.52061980
152High pitched voice (HP:0001620)1.51969391
153Horseshoe kidney (HP:0000085)1.51654302
154Fibrous tissue neoplasm (HP:0012316)1.51564420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.62043564
2MARK13.87897129
3SMG12.48790422
4CDK122.43813516
5BUB12.30199416
6EEF2K2.20565683
7NEK22.13126155
8ERBB32.12294724
9MAP3K102.06584579
10SIK22.00198149
11KSR11.92260453
12MAP3K41.85842439
13PASK1.85061400
14BRD41.77063316
15NTRK21.75050441
16MKNK11.73280624
17PKN21.72496398
18SCYL21.68557957
19MAPK131.60572105
20CAMK1G1.54267795
21SRPK11.54228555
22CDK71.49392970
23CDK81.46789564
24NTRK31.42449040
25MKNK21.41714746
26CDK61.36769140
27UHMK11.35535571
28MINK11.35075822
29ATR1.34846378
30LATS21.30679408
31CCNB11.28535710
32PNCK1.22236173
33PLK31.19064435
34CHEK21.18902624
35MET1.15954862
36CHEK11.13958332
37CAMKK11.13534516
38TRIB31.12707933
39TYRO31.12534498
40FGFR21.12248514
41CAMK1D1.09580744
42PLK21.08398065
43SIK11.04138458
44EIF2AK11.03154801
45CSNK1A1L1.02395735
46ICK1.02299449
47TAF11.01851124
48ALK1.01241515
49AURKA1.00559990
50MAP3K90.98312356
51PRPF4B0.95865966
52CSNK1G20.95804066
53* ATM0.92147305
54BRAF0.91807215
55PDGFRA0.91454439
56CDK10.90000829
57BRSK10.89601376
58CDK90.88376438
59CDK40.88149471
60PLK10.88021017
61CDK20.87949912
62MAP3K80.86891705
63PTK60.86132072
64PAK60.85677172
65IRAK30.85630460
66MST1R0.84494167
67LATS10.84015284
68AURKB0.83582222
69NEK10.83152040
70MTOR0.82437175
71PTK20.82337121
72CSNK1G30.82124807
73MAPK110.80749320
74PRKD30.80675716
75NTRK10.80490435
76FGFR10.78077285
77TTK0.76875685
78EPHB20.76077995
79TSSK60.74667286
80TTN0.73344154
81MELK0.70277938
82CDK180.68852295
83DYRK20.68743037
84STK40.68494231
85CDK150.67332798
86KSR20.66714718
87PRKDC0.66594786
88ERBB20.65376498
89CSNK1D0.65325034
90PDGFRB0.65114262
91RET0.64760624
92TGFBR10.63672173
93WEE10.63320951
94CDK140.62423900
95EPHA20.61645549
96PBK0.59519691
97MAP2K70.59154608
98RPS6KA20.58652613
99MAPK140.58652126
100WNK10.57504044
101GSK3B0.57189196
102DYRK1A0.56843533
103DYRK1B0.56756768
104SGK30.56556081
105CDK11A0.55338077
106CSNK1G10.54996314
107MAPK90.53936627
108FGFR40.53725336
109SGK20.52746637
110CDK50.52453290
111STK30.52001374
112CSNK1E0.51938423
113PLK40.50887857
114PAK20.50886031
115STK110.50849006
116ACVR1B0.49928984
117FGFR30.49500611
118MAPK100.49410492
119DMPK0.49258317
120MAPK80.48939290
121RPS6KB10.48850363
122RPS6KB20.48404031
123BRSK20.47793087
124HIPK20.47528285
125CLK10.47253496
126RIPK10.46816468
127CASK0.46304703
128SGK10.44616011
129AKT20.43651348
130AKT10.40116308
131BMX0.38314000
132EIF2AK20.38033713
133NEK90.36372055
134ERBB40.35209404

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.09206197
2DNA replication_Homo sapiens_hsa030301.94302064
3mRNA surveillance pathway_Homo sapiens_hsa030151.93186439
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75525412
5Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70801965
6Thyroid cancer_Homo sapiens_hsa052161.67645944
7Oocyte meiosis_Homo sapiens_hsa041141.67564075
8Colorectal cancer_Homo sapiens_hsa052101.66181390
9Alcoholism_Homo sapiens_hsa050341.55165738
10Spliceosome_Homo sapiens_hsa030401.54631964
11Long-term potentiation_Homo sapiens_hsa047201.52837111
12Glioma_Homo sapiens_hsa052141.52297176
13Mismatch repair_Homo sapiens_hsa034301.52044148
14Endometrial cancer_Homo sapiens_hsa052131.50750442
15Axon guidance_Homo sapiens_hsa043601.49765985
16One carbon pool by folate_Homo sapiens_hsa006701.48898649
17Chronic myeloid leukemia_Homo sapiens_hsa052201.45449397
18Nicotine addiction_Homo sapiens_hsa050331.44428347
19Systemic lupus erythematosus_Homo sapiens_hsa053221.44154850
20MicroRNAs in cancer_Homo sapiens_hsa052061.43989927
21RNA transport_Homo sapiens_hsa030131.35340202
22Non-small cell lung cancer_Homo sapiens_hsa052231.33826045
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32796027
24Fanconi anemia pathway_Homo sapiens_hsa034601.30662585
25Dopaminergic synapse_Homo sapiens_hsa047281.28927966
26mTOR signaling pathway_Homo sapiens_hsa041501.27815039
27Basal cell carcinoma_Homo sapiens_hsa052171.24399870
28Bladder cancer_Homo sapiens_hsa052191.21712313
29Dorso-ventral axis formation_Homo sapiens_hsa043201.17140571
30ErbB signaling pathway_Homo sapiens_hsa040121.16654961
31Circadian entrainment_Homo sapiens_hsa047131.13827156
32Pancreatic cancer_Homo sapiens_hsa052121.11851180
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11145825
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10801467
35Glutamatergic synapse_Homo sapiens_hsa047241.10797825
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.09733506
37Estrogen signaling pathway_Homo sapiens_hsa049151.09147741
38Olfactory transduction_Homo sapiens_hsa047401.09017338
39Wnt signaling pathway_Homo sapiens_hsa043101.08483491
40Gap junction_Homo sapiens_hsa045401.07879564
41Base excision repair_Homo sapiens_hsa034101.07670238
42Viral carcinogenesis_Homo sapiens_hsa052031.06453294
43Amphetamine addiction_Homo sapiens_hsa050311.05004793
44Long-term depression_Homo sapiens_hsa047301.04881265
45Type II diabetes mellitus_Homo sapiens_hsa049301.04176336
46Renal cell carcinoma_Homo sapiens_hsa052111.03967872
47Hippo signaling pathway_Homo sapiens_hsa043901.02540366
48HTLV-I infection_Homo sapiens_hsa051661.01042058
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00078369
50Hedgehog signaling pathway_Homo sapiens_hsa043400.99334715
51Morphine addiction_Homo sapiens_hsa050320.98093672
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97760709
53Cholinergic synapse_Homo sapiens_hsa047250.97104736
54Viral myocarditis_Homo sapiens_hsa054160.96668968
55Melanogenesis_Homo sapiens_hsa049160.96421037
56Biosynthesis of amino acids_Homo sapiens_hsa012300.96219219
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95775890
58GnRH signaling pathway_Homo sapiens_hsa049120.94644422
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93653164
60p53 signaling pathway_Homo sapiens_hsa041150.93369988
61Oxytocin signaling pathway_Homo sapiens_hsa049210.92658090
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92507099
63Basal transcription factors_Homo sapiens_hsa030220.92502010
64Small cell lung cancer_Homo sapiens_hsa052220.91435153
65Renin secretion_Homo sapiens_hsa049240.90915825
66Pyrimidine metabolism_Homo sapiens_hsa002400.89763157
67VEGF signaling pathway_Homo sapiens_hsa043700.89673242
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89402463
69Non-homologous end-joining_Homo sapiens_hsa034500.88660257
70Prostate cancer_Homo sapiens_hsa052150.88143197
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87314361
72Adherens junction_Homo sapiens_hsa045200.86480493
73Proteoglycans in cancer_Homo sapiens_hsa052050.85473845
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83774015
75GABAergic synapse_Homo sapiens_hsa047270.82430087
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82145641
77AMPK signaling pathway_Homo sapiens_hsa041520.81977755
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81300527
79Acute myeloid leukemia_Homo sapiens_hsa052210.80641499
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.79641637
81* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78890999
82Homologous recombination_Homo sapiens_hsa034400.78153533
83RNA degradation_Homo sapiens_hsa030180.77461536
84T cell receptor signaling pathway_Homo sapiens_hsa046600.76057001
85Nucleotide excision repair_Homo sapiens_hsa034200.75542523
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75476924
87Inositol phosphate metabolism_Homo sapiens_hsa005620.74591960
88Cocaine addiction_Homo sapiens_hsa050300.74427703
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74171311
90FoxO signaling pathway_Homo sapiens_hsa040680.73469479
91MAPK signaling pathway_Homo sapiens_hsa040100.73137774
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72918864
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71986273
94Hepatitis B_Homo sapiens_hsa051610.71592942
95Notch signaling pathway_Homo sapiens_hsa043300.71520671
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70972757
97B cell receptor signaling pathway_Homo sapiens_hsa046620.70465392
98TGF-beta signaling pathway_Homo sapiens_hsa043500.68367621
99Melanoma_Homo sapiens_hsa052180.68003948
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67660871
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67170723
102Synaptic vesicle cycle_Homo sapiens_hsa047210.66599586
103Pathways in cancer_Homo sapiens_hsa052000.66254825
104Prolactin signaling pathway_Homo sapiens_hsa049170.65519787
105* Lysine degradation_Homo sapiens_hsa003100.65195822
106Gastric acid secretion_Homo sapiens_hsa049710.64246714
107Choline metabolism in cancer_Homo sapiens_hsa052310.64225788
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.64113442
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62771581
110Tight junction_Homo sapiens_hsa045300.62770477
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62379974
112Focal adhesion_Homo sapiens_hsa045100.62028275
113Insulin signaling pathway_Homo sapiens_hsa049100.61371450
114Rap1 signaling pathway_Homo sapiens_hsa040150.61123709
115Pentose phosphate pathway_Homo sapiens_hsa000300.57937397
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55243313
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52570101
118N-Glycan biosynthesis_Homo sapiens_hsa005100.49673563
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49481051
120Vitamin B6 metabolism_Homo sapiens_hsa007500.46517196
121Selenocompound metabolism_Homo sapiens_hsa004500.42902957
122Thyroid hormone synthesis_Homo sapiens_hsa049180.40893836
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.40503649
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39061131
125Glucagon signaling pathway_Homo sapiens_hsa049220.38786244
126HIF-1 signaling pathway_Homo sapiens_hsa040660.38480150
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38309111
128Apoptosis_Homo sapiens_hsa042100.37073734
129ECM-receptor interaction_Homo sapiens_hsa045120.35384037

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