WHSC1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.28491647
2positive regulation of gamma-delta T cell activation (GO:0046645)4.85695884
3negative T cell selection (GO:0043383)4.33202979
4negative thymic T cell selection (GO:0045060)4.26136009
5nucleobase catabolic process (GO:0046113)4.13841089
6presynaptic membrane assembly (GO:0097105)4.03764864
7negative regulation of cell killing (GO:0031342)3.99181583
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99181583
9presynaptic membrane organization (GO:0097090)3.91533553
10positive T cell selection (GO:0043368)3.88716432
11peptidyl-lysine trimethylation (GO:0018023)3.84229767
12establishment of nucleus localization (GO:0040023)3.83513078
13histone H3-K4 trimethylation (GO:0080182)3.81405533
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80247838
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.80247838
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.79958352
17cytoplasmic mRNA processing body assembly (GO:0033962)3.78324825
18antigen processing and presentation of endogenous antigen (GO:0019883)3.75100170
19neural tube formation (GO:0001841)3.74072866
20interferon-gamma production (GO:0032609)3.73185957
21T cell selection (GO:0045058)3.72065406
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69091964
23establishment of mitochondrion localization (GO:0051654)3.69014508
24axonal fasciculation (GO:0007413)3.68615720
25regulation of T cell tolerance induction (GO:0002664)3.64526065
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.61291052
27regulation of translation, ncRNA-mediated (GO:0045974)3.61291052
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.61291052
29positive thymic T cell selection (GO:0045059)3.59502044
30central nervous system projection neuron axonogenesis (GO:0021952)3.58679756
31postsynaptic membrane organization (GO:0001941)3.58379632
32neuron cell-cell adhesion (GO:0007158)3.48419155
33neuron recognition (GO:0008038)3.47568769
34regulation of gamma-delta T cell differentiation (GO:0045586)3.44822737
35response to interleukin-15 (GO:0070672)3.44007043
36negative regulation of neurotransmitter secretion (GO:0046929)3.42249315
37mitochondrion transport along microtubule (GO:0047497)3.41762797
38establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41762797
39thymic T cell selection (GO:0045061)3.41307731
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41256992
41regulation of gamma-delta T cell activation (GO:0046643)3.40759730
42hindbrain development (GO:0030902)3.40242788
43histone H3-K9 methylation (GO:0051567)3.33573806
44establishment of protein localization to Golgi (GO:0072600)3.33431573
45nucleus localization (GO:0051647)3.32286925
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32270154
47leukocyte aggregation (GO:0070486)3.32028934
48histone H3-K9 modification (GO:0061647)3.31228635
49tolerance induction (GO:0002507)3.30366501
50regulation of B cell receptor signaling pathway (GO:0050855)3.30274952
51cellular response to interleukin-15 (GO:0071350)3.28656568
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.27637971
53phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.26247786
54histone mRNA catabolic process (GO:0071044)3.23110469
55response to type I interferon (GO:0034340)3.18482946
56cerebellar Purkinje cell differentiation (GO:0021702)3.17166076
57dendritic spine morphogenesis (GO:0060997)3.12633054
58type I interferon signaling pathway (GO:0060337)3.11056626
59cellular response to type I interferon (GO:0071357)3.11056626
60protein targeting to Golgi (GO:0000042)3.11030874
61T cell migration (GO:0072678)3.09444606
62central nervous system neuron axonogenesis (GO:0021955)3.09171115
63regulation of interleukin-12 biosynthetic process (GO:0045075)3.08098715
64mRNA splice site selection (GO:0006376)3.06247288
65retrograde transport, vesicle recycling within Golgi (GO:0000301)3.06170174
66positive regulation of interleukin-2 production (GO:0032743)3.02619370
67cell migration in hindbrain (GO:0021535)3.01356504
68mechanosensory behavior (GO:0007638)3.00552747
69regulation of alpha-beta T cell proliferation (GO:0046640)2.99901060
70regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.94410309
71positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.94410309
72positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.93882661
73regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.93882661
74regulation of regulatory T cell differentiation (GO:0045589)2.93741393
75regulation of interleukin-2 biosynthetic process (GO:0045076)2.92651862
76protein localization to synapse (GO:0035418)2.92481482
77interkinetic nuclear migration (GO:0022027)2.92313483
78dendrite morphogenesis (GO:0048813)2.92156860
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91998561
80negative regulation of neurotransmitter transport (GO:0051589)2.91900912
81alpha-beta T cell activation (GO:0046631)2.89571667
82CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.88962258
83alpha-beta T cell differentiation (GO:0046632)2.87962555
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87055607
85* histone lysine methylation (GO:0034968)2.87028911
86regulation of B cell differentiation (GO:0045577)2.84139085
87positive regulation of B cell differentiation (GO:0045579)2.83201731
88cerebral cortex radially oriented cell migration (GO:0021799)2.82771523
89peptidyl-lysine methylation (GO:0018022)2.80892689
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79996323
91B cell homeostasis (GO:0001782)2.79815434
92regulation of isotype switching to IgG isotypes (GO:0048302)2.78940693
93mast cell activation (GO:0045576)2.77948133
94nerve growth factor signaling pathway (GO:0038180)2.77809391
95behavioral response to nicotine (GO:0035095)2.76646445
96regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.76466186
97spinal cord development (GO:0021510)2.76424638
98synaptic vesicle maturation (GO:0016188)2.75336117
99regulation of NFAT protein import into nucleus (GO:0051532)2.74999213
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74786515
101T-helper cell differentiation (GO:0042093)2.74351994
102CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.74351994
103T cell receptor signaling pathway (GO:0050852)2.73091886
104B cell receptor signaling pathway (GO:0050853)2.71402109
105antigen receptor-mediated signaling pathway (GO:0050851)2.69617174
106organelle transport along microtubule (GO:0072384)2.69426452
107synapse assembly (GO:0007416)2.69156506
108negative regulation of T cell mediated immunity (GO:0002710)2.68367988
109regulation of T cell receptor signaling pathway (GO:0050856)2.68027386
110startle response (GO:0001964)2.64883815
111auditory behavior (GO:0031223)2.64274152
112nonmotile primary cilium assembly (GO:0035058)2.63467535
113vocalization behavior (GO:0071625)2.62397066
114T-helper 1 type immune response (GO:0042088)2.60626175
115dendritic cell chemotaxis (GO:0002407)2.60239190
116microtubule anchoring (GO:0034453)2.59926711
117myeloid dendritic cell activation (GO:0001773)2.58773244
118positive regulation of mRNA processing (GO:0050685)2.58253817
119interferon-gamma-mediated signaling pathway (GO:0060333)2.57293120
120regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.56349305
121positive regulation of B cell proliferation (GO:0030890)2.56250910
122positive regulation of mRNA catabolic process (GO:0061014)2.56078982
123glutamate receptor signaling pathway (GO:0007215)2.55723362
124monoubiquitinated protein deubiquitination (GO:0035520)2.55622006
125regulation of tolerance induction (GO:0002643)2.55272659
126positive regulation of natural killer cell differentiation (GO:0032825)2.54042559
127positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53768092
128cilium or flagellum-dependent cell motility (GO:0001539)2.53638475
129histone H3-K9 demethylation (GO:0033169)2.53186357
130JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.53019915
131microtubule nucleation (GO:0007020)2.52817558
132T cell costimulation (GO:0031295)2.52426607
133histone H4-K16 acetylation (GO:0043984)2.52065626
134T cell homeostasis (GO:0043029)2.50038447
135CD4-positive, alpha-beta T cell activation (GO:0035710)2.49711294
136regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49334285
137cell differentiation involved in metanephros development (GO:0072202)2.48455306
138lymphocyte costimulation (GO:0031294)2.48228627
139mature B cell differentiation (GO:0002335)2.47973823
140NIK/NF-kappaB signaling (GO:0038061)2.47298012
141limb bud formation (GO:0060174)2.46998394
142positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46947129
143regulation of respiratory system process (GO:0044065)2.46689073
144lymphocyte homeostasis (GO:0002260)2.45684510
145cell differentiation in hindbrain (GO:0021533)2.44362723
146exploration behavior (GO:0035640)2.43860629
147definitive hemopoiesis (GO:0060216)2.43617656
148activated T cell proliferation (GO:0050798)2.43452941
149positive regulation of humoral immune response (GO:0002922)2.43183069
150negative regulation of dendrite development (GO:2000171)2.43126189
151forebrain neuron differentiation (GO:0021879)2.42751652
152positive regulation of interleukin-17 production (GO:0032740)2.42653721
153positive regulation of tolerance induction (GO:0002645)2.42198211
154positive regulation of mRNA metabolic process (GO:1903313)2.41925363
155defense response to protozoan (GO:0042832)2.41866627
156regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41844702
157myeloid dendritic cell differentiation (GO:0043011)2.41191050
158vesicle transport along microtubule (GO:0047496)2.41054527
159dosage compensation (GO:0007549)2.40685943
160positive regulation of B cell activation (GO:0050871)2.40507452
161regulation of synaptic vesicle exocytosis (GO:2000300)2.40030314
162adult walking behavior (GO:0007628)2.39666010
163neurotransmitter-gated ion channel clustering (GO:0072578)2.38614317
164modulation by virus of host process (GO:0019054)2.38145141
165neuron-neuron synaptic transmission (GO:0007270)2.37972590
166appendage development (GO:0048736)2.37695200
167limb development (GO:0060173)2.37695200
168synaptic transmission, glutamatergic (GO:0035249)2.37669722
169olfactory bulb development (GO:0021772)2.37648005
170modulation by symbiont of host cellular process (GO:0044068)2.37402739
171regulation of growth hormone secretion (GO:0060123)2.37253843
172protein K11-linked deubiquitination (GO:0035871)2.37231290
173regulation of interferon-beta biosynthetic process (GO:0045357)2.37182961
174response to muramyl dipeptide (GO:0032495)2.37111148
175regulation of mRNA splicing, via spliceosome (GO:0048024)2.37089927
176T cell differentiation (GO:0030217)2.37025705
177positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.36647870
178lymph node development (GO:0048535)2.36602834
179regulation of telomere maintenance (GO:0032204)2.36421508
180positive regulation of granulocyte differentiation (GO:0030854)2.36288813
181positive regulation of interferon-alpha production (GO:0032727)2.35703591
182histone H3-K4 methylation (GO:0051568)2.35203774
183fibroblast migration (GO:0010761)2.34898551
184response to protozoan (GO:0001562)2.34808520
185head development (GO:0060322)2.34765982
186regulation of mRNA catabolic process (GO:0061013)2.34430860
187positive regulation of cytokine biosynthetic process (GO:0042108)2.33058757
188regulation of B cell proliferation (GO:0030888)2.32999058
189regulation of interferon-alpha production (GO:0032647)2.32826413
190T cell differentiation involved in immune response (GO:0002292)2.32098494
191alpha-beta T cell differentiation involved in immune response (GO:0002293)2.32098494
192alpha-beta T cell activation involved in immune response (GO:0002287)2.32098494
193positive regulation of isotype switching (GO:0045830)2.31186826
194regulation of alpha-beta T cell activation (GO:0046634)2.29953656
195response to interferon-alpha (GO:0035455)2.29944515
196regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.29607854
197regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.29448482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.77054871
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.48422154
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.08487058
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.17628330
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08760997
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91838725
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89422273
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73998235
9RUNX_20019798_ChIP-Seq_JUKART_Human2.64020887
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.51377547
11IGF1R_20145208_ChIP-Seq_DFB_Human2.48008578
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43699228
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.34399009
14GBX2_23144817_ChIP-Seq_PC3_Human2.31719453
15SCL_19346495_ChIP-Seq_HPC-7_Human2.30325979
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30158081
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.25170700
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22931245
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20883702
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.19050008
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.09884612
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05581699
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97415897
24FUS_26573619_Chip-Seq_HEK293_Human1.96437864
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96329144
26GATA1_22025678_ChIP-Seq_K562_Human1.92668163
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.90923946
28EWS_26573619_Chip-Seq_HEK293_Human1.90314516
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89426271
30REST_21632747_ChIP-Seq_MESCs_Mouse1.87724177
31* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79354640
32AR_21572438_ChIP-Seq_LNCaP_Human1.78245589
33ZNF274_21170338_ChIP-Seq_K562_Hela1.76086046
34RNF2_27304074_Chip-Seq_NSC_Mouse1.75439589
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75015676
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74755646
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74755646
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73702998
39MYB_26560356_Chip-Seq_TH2_Human1.71481559
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71086706
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70723421
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60182096
43VDR_24787735_ChIP-Seq_THP-1_Human1.59112307
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.56898792
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.56184448
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56166494
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54004221
48TAF15_26573619_Chip-Seq_HEK293_Human1.53844818
49* TCF4_23295773_ChIP-Seq_U87_Human1.51574635
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50746915
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48724719
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48114738
53ER_23166858_ChIP-Seq_MCF-7_Human1.42561144
54MYB_26560356_Chip-Seq_TH1_Human1.42541840
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42378526
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42036246
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.38825043
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38720048
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38457601
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38365068
61MAF_26560356_Chip-Seq_TH1_Human1.35547135
62VDR_22108803_ChIP-Seq_LS180_Human1.35303528
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33241494
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.31037033
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.30753945
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.30696460
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29448914
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29217734
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28128800
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26730841
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25555884
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24079119
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.23585591
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23280839
75PU_27001747_Chip-Seq_BMDM_Mouse1.21060196
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.20599969
77CBP_20019798_ChIP-Seq_JUKART_Human1.20409626
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20409626
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20086569
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19991747
81VDR_24763502_ChIP-Seq_THP-1_Human1.18592589
82EZH2_22144423_ChIP-Seq_EOC_Human1.18290853
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17786325
84RUNX2_22187159_ChIP-Seq_PCA_Human1.17573829
85AR_19668381_ChIP-Seq_PC3_Human1.17259589
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.16059341
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15723533
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14918008
89SOX9_26525672_Chip-Seq_HEART_Mouse1.14768494
90SPI1_23127762_ChIP-Seq_K562_Human1.13607171
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13540663
92GATA3_27048872_Chip-Seq_THYMUS_Human1.12895001
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12448733
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12236489
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11024197
96TP53_16413492_ChIP-PET_HCT116_Human1.10806150
97UTX_26944678_Chip-Seq_JUKART_Human1.10746724
98* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10724338
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09236693
100BCAT_22108803_ChIP-Seq_LS180_Human1.08613814
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08201643
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08044061
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.07876306
104SMAD4_21799915_ChIP-Seq_A2780_Human1.07817053
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07733281
106DROSHA_22980978_ChIP-Seq_HELA_Human1.06713885
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05981305
108IRF1_19129219_ChIP-ChIP_H3396_Human1.05128550
109JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05044476
110AHR_22903824_ChIP-Seq_MCF-7_Human1.04948823
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04165179
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04021862
113KDM2B_26808549_Chip-Seq_REH_Human1.03845072
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03461110
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03239870
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02372144
117P300_19829295_ChIP-Seq_ESCs_Human1.02340437
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02293239
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02007041
120TCF7_22412390_ChIP-Seq_EML_Mouse1.00690388
121RXR_22108803_ChIP-Seq_LS180_Human0.99570106
122EED_16625203_ChIP-ChIP_MESCs_Mouse0.99095869
123EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98416528
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.98352365
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.96513507
126* GATA1_19941827_ChIP-Seq_MEL_Mouse0.93981237
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93795044
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.93624111
129BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93209181
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92840003
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.90700591
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90222871
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90186299
134STAT3_23295773_ChIP-Seq_U87_Human0.89469112
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88628874
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87610674
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87498560
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.87191865
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87089975
140JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86945863
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.86735369
142KDM2B_26808549_Chip-Seq_JURKAT_Human0.86720619
143GATA3_26560356_Chip-Seq_TH2_Human0.86478701
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.86311254
145MYC_22102868_ChIP-Seq_BL_Human0.86006617
146* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85695769
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83978040
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.83911138
149AR_25329375_ChIP-Seq_VCAP_Human0.83102816
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.81929444
151TP53_18474530_ChIP-ChIP_U2OS_Human0.81529906
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81276833
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80642529
154P53_22387025_ChIP-Seq_ESCs_Mouse0.80290785
155ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80219829
156KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79741976
157E2F1_18555785_Chip-Seq_ESCs_Mouse0.79702684
158SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.79690770
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79598682
160KDM2B_26808549_Chip-Seq_DND41_Human0.79316558
161GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78582734
162GATA2_19941826_ChIP-Seq_K562_Human0.78432001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.88286296
2MP0000569_abnormal_digit_pigmentation3.45888226
3MP0001835_abnormal_antigen_presentation3.45118139
4MP0008057_abnormal_DNA_replication3.44484150
5MP0003763_abnormal_thymus_physiology3.31683339
6MP0005671_abnormal_response_to3.27050803
7MP0004859_abnormal_synaptic_plasticity3.25601846
8MP0000778_abnormal_nervous_system2.93295898
9MP0001790_abnormal_immune_system2.86707224
10MP0005387_immune_system_phenotype2.86707224
11MP0008877_abnormal_DNA_methylation2.83233738
12MP0005409_darkened_coat_color2.82414597
13MP0002166_altered_tumor_susceptibility2.76007025
14MP0003122_maternal_imprinting2.73627826
15MP0003880_abnormal_central_pattern2.69340793
16MP0003121_genomic_imprinting2.69267004
17MP0003724_increased_susceptibility_to2.59628262
18MP0001800_abnormal_humoral_immune2.58833993
19MP0005000_abnormal_immune_tolerance2.54996895
20MP0005174_abnormal_tail_pigmentation2.45148408
21MP0000685_abnormal_immune_system2.37745979
22MP0002822_catalepsy2.37635179
23MP0005423_abnormal_somatic_nervous2.37437677
24MP0003436_decreased_susceptibility_to2.27765278
25MP0009785_altered_susceptibility_to2.25702902
26MP0002723_abnormal_immune_serum2.23990367
27MP0003303_peritoneal_inflammation2.23967475
28MP0002006_tumorigenesis2.23297535
29MP0003635_abnormal_synaptic_transmissio2.19110910
30MP0002452_abnormal_antigen_presenting2.16790293
31MP0001819_abnormal_immune_cell2.14685170
32MP0002420_abnormal_adaptive_immunity2.13784935
33MP0003300_gastrointestinal_ulcer2.12479246
34MP0005025_abnormal_response_to2.12206274
35MP0002148_abnormal_hypersensitivity_rea2.11778972
36MP0000015_abnormal_ear_pigmentation2.04454850
37MP0002419_abnormal_innate_immunity2.01617595
38MP0002638_abnormal_pupillary_reflex1.97654641
39MP0002063_abnormal_learning/memory/cond1.95225203
40MP0002398_abnormal_bone_marrow1.90174291
41MP0004270_analgesia1.90040135
42MP0004510_myositis1.86668416
43MP0002405_respiratory_system_inflammati1.77471067
44MP0002396_abnormal_hematopoietic_system1.76941003
45MP0000716_abnormal_immune_system1.75079095
46MP0003890_abnormal_embryonic-extraembry1.74931137
47MP0000955_abnormal_spinal_cord1.71959647
48MP0005464_abnormal_platelet_physiology1.71458228
49MP0009046_muscle_twitch1.70829971
50MP0004381_abnormal_hair_follicle1.69372597
51MP0003183_abnormal_peptide_metabolism1.68560891
52MP0001984_abnormal_olfaction1.68231311
53MP0006292_abnormal_olfactory_placode1.67144953
54MP0001873_stomach_inflammation1.66164563
55MP0002009_preneoplasia1.65833381
56MP0001486_abnormal_startle_reflex1.65596456
57MP0010155_abnormal_intestine_physiology1.65525727
58MP0005646_abnormal_pituitary_gland1.65471459
59MP0004808_abnormal_hematopoietic_stem1.65180400
60MP0002735_abnormal_chemical_nociception1.64167838
61MP0006082_CNS_inflammation1.63656910
62MP0009745_abnormal_behavioral_response1.63622820
63MP0000703_abnormal_thymus_morphology1.61288484
64MP0004811_abnormal_neuron_physiology1.60071243
65MP0006276_abnormal_autonomic_nervous1.59304788
66MP0002572_abnormal_emotion/affect_behav1.58022078
67MP0002184_abnormal_innervation1.54594694
68MP0001853_heart_inflammation1.54131354
69MP0008995_early_reproductive_senescence1.54029098
70MP0004885_abnormal_endolymph1.53686424
71MP0003866_abnormal_defecation1.53026537
72MP0002064_seizures1.52192400
73MP0000631_abnormal_neuroendocrine_gland1.51204332
74MP0002557_abnormal_social/conspecific_i1.50807125
75MP0009333_abnormal_splenocyte_physiolog1.48406932
76MP0002734_abnormal_mechanical_nocicepti1.48403937
77MP0001968_abnormal_touch/_nociception1.47020088
78MP0005645_abnormal_hypothalamus_physiol1.45661007
79MP0002272_abnormal_nervous_system1.45602376
80MP0005394_taste/olfaction_phenotype1.45124201
81MP0005499_abnormal_olfactory_system1.45124201
82MP0002067_abnormal_sensory_capabilities1.44620479
83MP0002095_abnormal_skin_pigmentation1.42907016
84MP0002722_abnormal_immune_system1.39839143
85MP0000427_abnormal_hair_cycle1.37236340
86MP0001845_abnormal_inflammatory_respons1.36275019
87MP0000689_abnormal_spleen_morphology1.35836689
88MP0002882_abnormal_neuron_morphology1.35149387
89MP0002653_abnormal_ependyma_morphology1.34999996
90MP0004947_skin_inflammation1.33607705
91MP0004924_abnormal_behavior1.28875892
92MP0005386_behavior/neurological_phenoty1.28875892
93MP0002429_abnormal_blood_cell1.27915297
94MP0002152_abnormal_brain_morphology1.27483735
95MP0002102_abnormal_ear_morphology1.26878465
96MP0001188_hyperpigmentation1.25117308
97MP0002998_abnormal_bone_remodeling1.24418457
98MP0005187_abnormal_penis_morphology1.23358349
99MP0002909_abnormal_adrenal_gland1.22698484
100MP0000465_gastrointestinal_hemorrhage1.20947244
101MP0001533_abnormal_skeleton_physiology1.20937795
102MP0009764_decreased_sensitivity_to1.18196751
103MP0002933_joint_inflammation1.17856068
104MP0003861_abnormal_nervous_system1.17847421
105MP0009278_abnormal_bone_marrow1.15647658
106MP0004742_abnormal_vestibular_system1.14935970
107MP0001851_eye_inflammation1.12763725
108MP0005310_abnormal_salivary_gland1.12549048
109MP0003941_abnormal_skin_development1.09409532
110MP0002736_abnormal_nociception_after1.09330309
111MP0005397_hematopoietic_system_phenotyp1.09225173
112MP0001545_abnormal_hematopoietic_system1.09225173
113MP0003045_fibrosis1.09152556
114MP0004142_abnormal_muscle_tone1.08810487
115MP0009780_abnormal_chondrocyte_physiolo1.08606006
116MP0003943_abnormal_hepatobiliary_system1.04993395
117MP0003091_abnormal_cell_migration1.01267104
118MP0002751_abnormal_autonomic_nervous1.01147264
119MP0002928_abnormal_bile_duct0.99642716
120MP0001970_abnormal_pain_threshold0.99601095
121MP0002752_abnormal_somatic_nervous0.99393501
122MP0001440_abnormal_grooming_behavior0.97276746
123MP0008789_abnormal_olfactory_epithelium0.96301875
124MP0008469_abnormal_protein_level0.94113133
125MP0003938_abnormal_ear_development0.93799195
126MP0009379_abnormal_foot_pigmentation0.90630416
127MP0002877_abnormal_melanocyte_morpholog0.89987729
128MP0002733_abnormal_thermal_nociception0.89879379
129MP0001501_abnormal_sleep_pattern0.87189427
130MP0005551_abnormal_eye_electrophysiolog0.85776802
131MP0002693_abnormal_pancreas_physiology0.85579002
132MP0002066_abnormal_motor_capabilities/c0.84321805
133MP0002081_perinatal_lethality0.83978299
134MP0001529_abnormal_vocalization0.83809311
135MP0003633_abnormal_nervous_system0.81912003
136MP0003172_abnormal_lysosome_physiology0.81078986
137MP0002177_abnormal_outer_ear0.80285363
138MP0001177_atelectasis0.80197024
139MP0003448_altered_tumor_morphology0.79653134
140MP0005253_abnormal_eye_physiology0.79191136
141MP0009703_decreased_birth_body0.79085169
142MP0005075_abnormal_melanosome_morpholog0.77869450
143MP0002138_abnormal_hepatobiliary_system0.77747604
144MP0003631_nervous_system_phenotype0.76641590
145MP0010770_preweaning_lethality0.76530856
146MP0002082_postnatal_lethality0.76530856
147MP0000371_diluted_coat_color0.76484857
148MP0001286_abnormal_eye_development0.75793622
149MP0000383_abnormal_hair_follicle0.74829206
150MP0001879_abnormal_lymphatic_vessel0.74738960
151MP0004133_heterotaxia0.74188547
152MP0001943_abnormal_respiration0.73186071
153MP0002233_abnormal_nose_morphology0.73126483
154MP0010769_abnormal_survival0.72585272
155MP0010768_mortality/aging0.72267673
156MP0008569_lethality_at_weaning0.72043721
157MP0006072_abnormal_retinal_apoptosis0.70605168
158MP0008007_abnormal_cellular_replicative0.70526639
159MP0008961_abnormal_basal_metabolism0.70470103
160MP0005248_abnormal_Harderian_gland0.69765295
161MP0004043_abnormal_pH_regulation0.69486441
162MP0002069_abnormal_eating/drinking_beha0.69398733
163MP0005390_skeleton_phenotype0.69395394
164MP0001485_abnormal_pinna_reflex0.68697824
165MP0003868_abnormal_feces_composition0.68151205
166MP0000767_abnormal_smooth_muscle0.66857302
167MP0004134_abnormal_chest_morphology0.65755205
168MP0000858_altered_metastatic_potential0.65450577
169MP0001958_emphysema0.65091072
170MP0003935_abnormal_craniofacial_develop0.64354434
171MP0003632_abnormal_nervous_system0.63740052
172MP0005379_endocrine/exocrine_gland_phen0.63480755
173MP0003937_abnormal_limbs/digits/tail_de0.63031241
174MP0003828_pulmonary_edema0.62285398
175MP0003123_paternal_imprinting0.62213552
176MP0002163_abnormal_gland_morphology0.61094430
177MP0009763_increased_sensitivity_to0.58991521
178MP0002876_abnormal_thyroid_physiology0.57159287
179MP0003252_abnormal_bile_duct0.54643503
180MP0003795_abnormal_bone_structure0.53444342
181MP0005257_abnormal_intraocular_pressure0.53292380
182MP0000920_abnormal_myelination0.52393638
183MP0000249_abnormal_blood_vessel0.51874009
184MP0005076_abnormal_cell_differentiation0.50948962
185MP0001191_abnormal_skin_condition0.49844276
186MP0001502_abnormal_circadian_rhythm0.49717466

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.25089854
2Hyperventilation (HP:0002883)3.70480665
3Recurrent viral infections (HP:0004429)3.49777805
4Elevated erythrocyte sedimentation rate (HP:0003565)3.44969598
5T lymphocytopenia (HP:0005403)3.44398286
6Abnormality of T cell number (HP:0011839)3.42749248
7Pulmonary infiltrates (HP:0002113)3.41905118
8Autoimmune thrombocytopenia (HP:0001973)3.39595292
9Chronic otitis media (HP:0000389)3.36793707
10Recurrent fungal infections (HP:0002841)3.35728440
11Eosinophilia (HP:0001880)3.35015174
12Volvulus (HP:0002580)3.33087110
13Myositis (HP:0100614)3.31549649
14Agammaglobulinemia (HP:0004432)3.31002825
15Optic neuritis (HP:0100653)3.28521260
16Retrobulbar optic neuritis (HP:0100654)3.28521260
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.24903645
18Drooling (HP:0002307)3.22101972
19Recurrent cutaneous fungal infections (HP:0011370)3.21748246
20Chronic mucocutaneous candidiasis (HP:0002728)3.21748246
21Febrile seizures (HP:0002373)3.18576414
22Genetic anticipation (HP:0003743)3.10604693
23Papilledema (HP:0001085)3.09147904
24Excessive salivation (HP:0003781)3.07446886
25Eczematoid dermatitis (HP:0000976)3.06732322
26Meningitis (HP:0001287)3.00116236
27Recurrent abscess formation (HP:0002722)2.98206805
28Panhypogammaglobulinemia (HP:0003139)2.96546690
29Abnormality of eosinophils (HP:0001879)2.96341772
30Stomatitis (HP:0010280)2.96025591
31Vasculitis (HP:0002633)2.95495770
32Progressive cerebellar ataxia (HP:0002073)2.92279646
33Periodontitis (HP:0000704)2.90822914
34Protruding tongue (HP:0010808)2.87095043
35Orchitis (HP:0100796)2.86670549
36Aqueductal stenosis (HP:0002410)2.86133739
37Obstructive lung disease (HP:0006536)2.85633183
38Chronic obstructive pulmonary disease (HP:0006510)2.85633183
39Focal seizures (HP:0007359)2.82609996
40Leukocytosis (HP:0001974)2.80727627
41Thyroiditis (HP:0100646)2.80473118
42Mediastinal lymphadenopathy (HP:0100721)2.79363731
43Focal motor seizures (HP:0011153)2.79016322
44Recurrent bacterial skin infections (HP:0005406)2.77673110
45Gait imbalance (HP:0002141)2.75585558
46Granulocytopenia (HP:0001913)2.74070177
47Broad-based gait (HP:0002136)2.59915089
48Gastrointestinal stroma tumor (HP:0100723)2.53987065
49Severe combined immunodeficiency (HP:0004430)2.53546766
50Chronic hepatic failure (HP:0100626)2.52482628
51Recurrent skin infections (HP:0001581)2.50162839
52Abnormality of T cells (HP:0002843)2.47717595
53Poor coordination (HP:0002370)2.44688830
54Abnormality of the corticospinal tract (HP:0002492)2.42664354
55Truncal obesity (HP:0001956)2.42043046
56Hip dysplasia (HP:0001385)2.41828886
57Papillary thyroid carcinoma (HP:0002895)2.41222128
58Chronic diarrhea (HP:0002028)2.41083914
59Gingival bleeding (HP:0000225)2.39098263
60Tented upper lip vermilion (HP:0010804)2.38641817
61Myocardial infarction (HP:0001658)2.37736510
62Exotropia (HP:0000577)2.37195312
63Abnormality of the ischium (HP:0003174)2.37167397
64Oligodactyly (hands) (HP:0001180)2.35942911
65IgM deficiency (HP:0002850)2.35805851
66Medial flaring of the eyebrow (HP:0010747)2.35722182
67Hepatoblastoma (HP:0002884)2.33559233
68Arterial thrombosis (HP:0004420)2.33012759
69Epileptic encephalopathy (HP:0200134)2.30570967
70Hemoptysis (HP:0002105)2.29035116
71Recurrent bronchitis (HP:0002837)2.29033314
72Congenital primary aphakia (HP:0007707)2.27899865
73Hypoplasia of the thymus (HP:0000778)2.26702962
74Keratoconjunctivitis sicca (HP:0001097)2.26563577
75Hypoplastic ischia (HP:0003175)2.25211119
76High anterior hairline (HP:0009890)2.23197559
77Joint swelling (HP:0001386)2.21481259
78Abnormality of the nasal septum (HP:0000419)2.21435383
79Abnormality of the endocardium (HP:0004306)2.21284255
80B lymphocytopenia (HP:0010976)2.21136258
81Abnormality of B cell number (HP:0010975)2.21136258
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.19691427
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19691427
84Gastrointestinal infarctions (HP:0005244)2.18495331
85Spinal cord lesions (HP:0100561)2.18356795
86Syringomyelia (HP:0003396)2.18356795
87Recurrent gram-negative bacterial infections (HP:0005420)2.17955431
88Limb dystonia (HP:0002451)2.17560453
89Prolonged bleeding time (HP:0003010)2.16621975
90Heterotopia (HP:0002282)2.15983532
91Atonic seizures (HP:0010819)2.15868189
92Nephronophthisis (HP:0000090)2.14134690
93Epistaxis (HP:0000421)2.12961737
94Nephrogenic diabetes insipidus (HP:0009806)2.11762409
95Inflammation of the large intestine (HP:0002037)2.11491317
96Narrow palate (HP:0000189)2.11187558
97Lissencephaly (HP:0001339)2.08841452
98Colitis (HP:0002583)2.07031443
99Acute lymphatic leukemia (HP:0006721)2.05985379
100Pancreatic cysts (HP:0001737)2.05773681
101Lymphopenia (HP:0001888)2.05337860
102Absent speech (HP:0001344)2.04350547
103Gaze-evoked nystagmus (HP:0000640)2.04254234
104Absent frontal sinuses (HP:0002688)2.03104071
105Genital tract atresia (HP:0001827)2.02874628
106Abnormality of the pleura (HP:0002103)2.02503740
107Gingivitis (HP:0000230)2.02031910
108Keratoconjunctivitis (HP:0001096)2.01798041
109Autoimmune hemolytic anemia (HP:0001890)2.01636915
110Abnormality of the renal medulla (HP:0100957)1.99736407
111Vaginal atresia (HP:0000148)1.99618805
112Chronic sinusitis (HP:0011109)1.98400198
113Abnormality of the renal cortex (HP:0011035)1.98250581
114Encephalitis (HP:0002383)1.98035821
115Abnormality of the prostate (HP:0008775)1.97471479
116Lip pit (HP:0100267)1.96841577
117Neoplasm of the tracheobronchial system (HP:0100552)1.96544807
118Widely spaced teeth (HP:0000687)1.95919056
119Hypothermia (HP:0002045)1.95325422
120IgA deficiency (HP:0002720)1.93929379
121Pancreatic fibrosis (HP:0100732)1.93474452
122Abnormal hair whorl (HP:0010721)1.93251971
123Chest pain (HP:0100749)1.93000837
124Abnormality of cells of the lymphoid lineage (HP:0012140)1.92546602
125Submucous cleft hard palate (HP:0000176)1.92473037
126Combined immunodeficiency (HP:0005387)1.92156477
127Abnormality of T cell physiology (HP:0011840)1.91365556
128Abnormality of midbrain morphology (HP:0002418)1.90022073
129Molar tooth sign on MRI (HP:0002419)1.90022073
130Cellulitis (HP:0100658)1.89776634
131Glomerulopathy (HP:0100820)1.89710166
132Tubulointerstitial nephritis (HP:0001970)1.88769113
133Midline defect of the nose (HP:0004122)1.88715775
134Gastrointestinal inflammation (HP:0004386)1.87233287
135Macroorchidism (HP:0000053)1.86212035
136Short foot (HP:0001773)1.85640384
137Pachygyria (HP:0001302)1.85279819
138Pheochromocytoma (HP:0002666)1.85226358
139Cystic hygroma (HP:0000476)1.84719228
140IgG deficiency (HP:0004315)1.84048458
141Persistence of primary teeth (HP:0006335)1.83953132
142Recurrent sinusitis (HP:0011108)1.83591455
143Abnormality of salivation (HP:0100755)1.83096969
144Shawl scrotum (HP:0000049)1.82523097
145Tapered finger (HP:0001182)1.82392987
146Specific learning disability (HP:0001328)1.81569313
147Cupped ear (HP:0000378)1.80710439
148Renal cortical cysts (HP:0000803)1.80436637
149Urinary bladder sphincter dysfunction (HP:0002839)1.79319108
150Intestinal atresia (HP:0011100)1.79268676
151Thick eyebrow (HP:0000574)1.78458994
152Spondylolisthesis (HP:0003302)1.77228086
153Polyphagia (HP:0002591)1.76286255
154Alveolar cell carcinoma (HP:0006519)1.75807956
155Hypsarrhythmia (HP:0002521)1.75611432
156Highly arched eyebrow (HP:0002553)1.75347167
157Mitral stenosis (HP:0001718)1.75330773
158Osteomyelitis (HP:0002754)1.74660249
159Epileptiform EEG discharges (HP:0011182)1.74305798
160EEG with generalized epileptiform discharges (HP:0011198)1.73587256
161Neoplasm of the adrenal cortex (HP:0100641)1.73515256
162Myokymia (HP:0002411)1.71530789
163Emphysema (HP:0002097)1.71487988
164Ureteral obstruction (HP:0006000)1.70931117
165Spontaneous hematomas (HP:0007420)1.70859479
166Narrow forehead (HP:0000341)1.70451847
167Ureteral stenosis (HP:0000071)1.70443763
168Dialeptic seizures (HP:0011146)1.70223705
169True hermaphroditism (HP:0010459)1.70062522
170Morphological abnormality of the pyramidal tract (HP:0002062)1.69703336
171Curly hair (HP:0002212)1.69049376
172Abnormality of the labia minora (HP:0012880)1.68612362
173Hypoplastic iliac wings (HP:0002866)1.68331649
174Agitation (HP:0000713)1.68238772
175Increased IgM level (HP:0003496)1.67242167
176Obsessive-compulsive behavior (HP:0000722)1.66445746
177Vitreoretinal degeneration (HP:0000655)1.66059415
178Sepsis (HP:0100806)1.65195811
179Failure to thrive in infancy (HP:0001531)1.64557234
180Keratitis (HP:0000491)1.64348725
181Amyotrophic lateral sclerosis (HP:0007354)1.64326507
182Pulmonary embolism (HP:0002204)1.63953756
183Abnormality of incisor morphology (HP:0011063)1.62590034
184Fair hair (HP:0002286)1.61277291
185Intellectual disability, moderate (HP:0002342)1.61114128
186Oligodactyly (HP:0012165)1.61021287
187Retinal dysplasia (HP:0007973)1.60956744
188Medulloblastoma (HP:0002885)1.60556860
189Action tremor (HP:0002345)1.58764803
190Abnormal pancreas size (HP:0012094)1.58279109
191Intellectual disability, severe (HP:0010864)1.57667742
192Postaxial hand polydactyly (HP:0001162)1.55672632
193Thin upper lip vermilion (HP:0000219)1.55116886
194Astrocytoma (HP:0009592)1.54300153
195Abnormality of the astrocytes (HP:0100707)1.54300153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.02051951
2TXK3.58286906
3MAP3K143.04961004
4MAP4K12.95994550
5TNIK2.57868652
6JAK32.48369733
7TAOK32.29472973
8IKBKE2.27832900
9IRAK42.27123603
10JAK12.24740665
11MAP3K122.22343357
12TYK22.15774747
13NTRK22.14958498
14MAP3K42.05882965
15PNCK2.04378157
16MAP3K131.97437744
17NLK1.93430679
18IRAK31.93282944
19FGFR31.85293148
20TEC1.79909393
21BCR1.79866411
22FGFR41.79628177
23ITK1.74314598
24INSRR1.69245383
25SGK21.59446257
26CASK1.56170541
27FES1.54861176
28PAK31.54043131
29PDGFRA1.53342470
30MKNK21.47957325
31ZAP701.44588635
32KIT1.40916234
33CHUK1.36900767
34DYRK21.33981642
35IKBKB1.32795725
36SYK1.29963405
37PRKCH1.29871846
38SIK21.26417450
39DYRK1A1.26095223
40SGK31.25920976
41BMPR1B1.24785718
42LCK1.24191947
43RIPK41.23952339
44HIPK21.23593220
45LATS11.22528373
46BRD41.20547847
47YES11.20118880
48HCK1.17537261
49BTK1.16709726
50MAP4K21.14358580
51TBK11.14224435
52PDGFRB1.12925359
53PRKCQ1.12155989
54MAP3K101.11489421
55SIK31.08962906
56EPHA31.08131877
57TYRO31.07724593
58EPHA41.05758294
59KSR11.05633901
60MAPK151.03731078
61WNK31.03682646
62CSK1.02707154
63PRKD21.02612193
64JAK21.01686479
65CAMKK10.97868886
66MAP3K70.95554017
67STK240.95407351
68CAMK1G0.95334636
69MINK10.94640006
70UHMK10.94499689
71MAP2K70.94415497
72STK110.87878896
73MUSK0.87478131
74CSF1R0.84779281
75CDK190.84723657
76PIK3CA0.82729334
77PRPF4B0.81074382
78TNK20.78766372
79DYRK30.78053708
80PIM10.76497402
81IRAK10.75728875
82CDK120.74436364
83EIF2AK20.74258027
84EPHB10.73701613
85LYN0.71995887
86SGK4940.71906227
87SGK2230.71906227
88MAP2K40.71315284
89STK100.70578760
90SIK10.70231935
91SCYL20.70111678
92IRAK20.69430832
93BMPR20.68789898
94CDK50.68678011
95CLK10.67847241
96GRK60.65887349
97RPS6KB10.65008701
98NUAK10.64365621
99DYRK1B0.62670078
100PRKAA10.62507405
101TRIM280.62037660
102NEK60.61451318
103ICK0.61171748
104CAMK1D0.61011907
105MAPK70.60577679
106TGFBR20.59975942
107NTRK30.59934616
108ERN10.59930729
109SGK10.59037514
110RET0.58920186
111MAPK130.58424760
112AKT30.58380190
113CSNK1G20.56978031
114PLK20.56096619
115CAMKK20.56072553
116EIF2AK30.55900992
117FGFR20.55517468
118MAP3K20.55511051
119MAP3K10.55015166
120FRK0.54948253
121PRKCZ0.54851662
122PRKCG0.53607711
123TRPM70.53310180
124MKNK10.52416841
125MAPK100.51906464
126CAMK10.51234956
127CDK60.50260373
128CDK30.49495674
129PINK10.49259524
130BLK0.46792568
131EEF2K0.46625744
132IGF1R0.45769562
133CSNK1E0.44361076
134ERBB30.44242528
135MAPK80.43780071
136MARK30.43720323
137MAP3K50.43372808
138MAP3K90.43232760
139PRKAA20.42643490
140OXSR10.42081842
141GSK3B0.41983216
142WNK10.41875506
143RPS6KA40.41788268
144CAMK40.41644833
145ABL10.41214753
146BRSK20.40075795
147ATM0.39911824
148FYN0.38705240
149CSNK1D0.37871641
150PASK0.35159255
151ERBB20.35061548
152RPS6KA30.34245421
153ATR0.34180867
154RPS6KA20.33019237
155RPS6KA60.32083530
156MARK20.32075776

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.88545420
2Primary immunodeficiency_Homo sapiens_hsa053402.75211762
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.29069384
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.11937510
5Measles_Homo sapiens_hsa051622.11135627
6T cell receptor signaling pathway_Homo sapiens_hsa046602.09354689
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08161251
8Allograft rejection_Homo sapiens_hsa053301.95260220
9Osteoclast differentiation_Homo sapiens_hsa043801.94749172
10Leishmaniasis_Homo sapiens_hsa051401.90465981
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89156679
12Dopaminergic synapse_Homo sapiens_hsa047281.80610613
13Amphetamine addiction_Homo sapiens_hsa050311.79906976
14B cell receptor signaling pathway_Homo sapiens_hsa046621.78046196
15Glutamatergic synapse_Homo sapiens_hsa047241.77800340
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76828100
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69609295
18Graft-versus-host disease_Homo sapiens_hsa053321.69236428
19Axon guidance_Homo sapiens_hsa043601.59791011
20Cocaine addiction_Homo sapiens_hsa050301.58071787
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.52200014
22GABAergic synapse_Homo sapiens_hsa047271.51381671
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51052001
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50263969
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47396971
26Long-term depression_Homo sapiens_hsa047301.43175747
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42509258
28Hematopoietic cell lineage_Homo sapiens_hsa046401.41406377
29Taste transduction_Homo sapiens_hsa047421.39125129
30Influenza A_Homo sapiens_hsa051641.37370858
31Circadian rhythm_Homo sapiens_hsa047101.36081719
32Chemokine signaling pathway_Homo sapiens_hsa040621.31782622
33Toxoplasmosis_Homo sapiens_hsa051451.29337681
34TNF signaling pathway_Homo sapiens_hsa046681.29101276
35Autoimmune thyroid disease_Homo sapiens_hsa053201.28239974
36Hepatitis B_Homo sapiens_hsa051611.25692084
37mTOR signaling pathway_Homo sapiens_hsa041501.23601008
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22433652
39Type I diabetes mellitus_Homo sapiens_hsa049401.22318610
40Oxytocin signaling pathway_Homo sapiens_hsa049211.17256536
41Renal cell carcinoma_Homo sapiens_hsa052111.14681723
42Phototransduction_Homo sapiens_hsa047441.14589627
43Olfactory transduction_Homo sapiens_hsa047401.13365303
44Chronic myeloid leukemia_Homo sapiens_hsa052201.13157392
45Herpes simplex infection_Homo sapiens_hsa051681.11882410
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11186217
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10404436
48Acute myeloid leukemia_Homo sapiens_hsa052211.10327543
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08007253
50mRNA surveillance pathway_Homo sapiens_hsa030151.05910356
51Prostate cancer_Homo sapiens_hsa052151.04575146
52Estrogen signaling pathway_Homo sapiens_hsa049151.04324219
53Type II diabetes mellitus_Homo sapiens_hsa049301.02622156
54Staphylococcus aureus infection_Homo sapiens_hsa051501.02518282
55Prolactin signaling pathway_Homo sapiens_hsa049171.02512881
56Tuberculosis_Homo sapiens_hsa051521.02026882
57Malaria_Homo sapiens_hsa051441.01363762
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99552337
59African trypanosomiasis_Homo sapiens_hsa051430.99249598
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98985525
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98329954
62Serotonergic synapse_Homo sapiens_hsa047260.97859441
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97560558
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96949376
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96055556
66Pertussis_Homo sapiens_hsa051330.95435035
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94799455
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94728900
69Hepatitis C_Homo sapiens_hsa051600.94624859
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94103359
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94021137
72Salivary secretion_Homo sapiens_hsa049700.92528792
73Gap junction_Homo sapiens_hsa045400.92416724
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.92266427
75Ras signaling pathway_Homo sapiens_hsa040140.91598381
76Wnt signaling pathway_Homo sapiens_hsa043100.91056258
77Antigen processing and presentation_Homo sapiens_hsa046120.90473577
78GnRH signaling pathway_Homo sapiens_hsa049120.90433818
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.89706582
80Glioma_Homo sapiens_hsa052140.89412759
81Asthma_Homo sapiens_hsa053100.88664354
82Synaptic vesicle cycle_Homo sapiens_hsa047210.88513115
83Hedgehog signaling pathway_Homo sapiens_hsa043400.87470284
84Pancreatic cancer_Homo sapiens_hsa052120.86198673
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86046597
86* Lysine degradation_Homo sapiens_hsa003100.84154887
87Gastric acid secretion_Homo sapiens_hsa049710.83864159
88Fanconi anemia pathway_Homo sapiens_hsa034600.82161917
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81853207
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81771864
91Sulfur relay system_Homo sapiens_hsa041220.81457739
92Melanogenesis_Homo sapiens_hsa049160.81196725
93Viral myocarditis_Homo sapiens_hsa054160.80589439
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79971890
95Platelet activation_Homo sapiens_hsa046110.79954992
96ABC transporters_Homo sapiens_hsa020100.78860128
97Rap1 signaling pathway_Homo sapiens_hsa040150.77948927
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77717031
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77620650
100Regulation of autophagy_Homo sapiens_hsa041400.76595635
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75172219
102Calcium signaling pathway_Homo sapiens_hsa040200.75164548
103Non-small cell lung cancer_Homo sapiens_hsa052230.71590329
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70881527
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69573599
106Inositol phosphate metabolism_Homo sapiens_hsa005620.69505779
107Oocyte meiosis_Homo sapiens_hsa041140.68665678
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.67605470
109Hippo signaling pathway_Homo sapiens_hsa043900.67273579
110Insulin resistance_Homo sapiens_hsa049310.66722501
111Alcoholism_Homo sapiens_hsa050340.66336697
112ErbB signaling pathway_Homo sapiens_hsa040120.65755106
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65374271
114Endometrial cancer_Homo sapiens_hsa052130.64971710
115RNA degradation_Homo sapiens_hsa030180.63844998
116MAPK signaling pathway_Homo sapiens_hsa040100.63809823
117Adherens junction_Homo sapiens_hsa045200.63661570
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63636275
119MicroRNAs in cancer_Homo sapiens_hsa052060.63575896
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63527297
121Non-homologous end-joining_Homo sapiens_hsa034500.62755659
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62697721
123Apoptosis_Homo sapiens_hsa042100.62608052
124Salmonella infection_Homo sapiens_hsa051320.62280956
125FoxO signaling pathway_Homo sapiens_hsa040680.62080949
126VEGF signaling pathway_Homo sapiens_hsa043700.61701046
127HTLV-I infection_Homo sapiens_hsa051660.60874865
128AMPK signaling pathway_Homo sapiens_hsa041520.60725526
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.59522655
130Choline metabolism in cancer_Homo sapiens_hsa052310.59221253
131Basal cell carcinoma_Homo sapiens_hsa052170.58699641
132Rheumatoid arthritis_Homo sapiens_hsa053230.57415814
133Insulin secretion_Homo sapiens_hsa049110.56704941
134Melanoma_Homo sapiens_hsa052180.55263061
135Notch signaling pathway_Homo sapiens_hsa043300.54172773
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53479031
137Small cell lung cancer_Homo sapiens_hsa052220.52632776
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.52024006
139Colorectal cancer_Homo sapiens_hsa052100.50395881
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50039165
141Long-term potentiation_Homo sapiens_hsa047200.47906298
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46705512
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46693792
144Morphine addiction_Homo sapiens_hsa050320.45802540
145Cholinergic synapse_Homo sapiens_hsa047250.43747946
146cAMP signaling pathway_Homo sapiens_hsa040240.43355073
147Dorso-ventral axis formation_Homo sapiens_hsa043200.42961864
148Renin secretion_Homo sapiens_hsa049240.41935535
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40310192
150Shigellosis_Homo sapiens_hsa051310.39960975
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39202167
152Legionellosis_Homo sapiens_hsa051340.39183731
153Pancreatic secretion_Homo sapiens_hsa049720.37428409
154Circadian entrainment_Homo sapiens_hsa047130.37311175

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »