WIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kidney mesenchyme development (GO:0072074)9.41970971
2artery smooth muscle contraction (GO:0014824)9.06389141
3regulation of transforming growth factor beta2 production (GO:0032909)8.80488475
4myoblast migration (GO:0051451)8.56540494
5head development (GO:0060322)8.45114763
6glomerular filtration (GO:0003094)8.35571076
7positive regulation of odontogenesis (GO:0042482)8.33830897
8regulation of branching involved in prostate gland morphogenesis (GO:0060687)8.29910759
9histamine secretion (GO:0001821)8.22568999
10renal filtration (GO:0097205)7.48483961
11muscle cell proliferation (GO:0033002)7.48072269
12lateral sprouting from an epithelium (GO:0060601)7.31638737
13regulation of cardioblast differentiation (GO:0051890)7.30088885
14prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.06150698
15enteric nervous system development (GO:0048484)6.73275600
16histamine transport (GO:0051608)6.52554621
17mesenchymal-epithelial cell signaling (GO:0060638)6.51347075
18bone trabecula formation (GO:0060346)6.30767384
19regulation of secondary heart field cardioblast proliferation (GO:0003266)6.27372106
20regulation of cardioblast proliferation (GO:0003264)6.27372106
21segment specification (GO:0007379)5.81738039
22regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.63536992
23branching involved in prostate gland morphogenesis (GO:0060442)5.51151570
24positive regulation of hair follicle development (GO:0051798)5.50315191
25positive regulation of hair cycle (GO:0042635)5.50315191
26cranial nerve morphogenesis (GO:0021602)5.46038452
27vascular smooth muscle contraction (GO:0014829)5.45730293
28hemidesmosome assembly (GO:0031581)5.43922843
29regulation of alkaline phosphatase activity (GO:0010692)5.43428547
30nephron tubule formation (GO:0072079)5.38605428
31peripheral nervous system neuron development (GO:0048935)5.16809973
32tooth mineralization (GO:0034505)5.11581476
33planar cell polarity pathway involved in neural tube closure (GO:0090179)5.11534656
34cochlea morphogenesis (GO:0090103)5.09021187
35cell proliferation involved in metanephros development (GO:0072203)5.07668213
36regulation of hair follicle development (GO:0051797)5.02952386
37craniofacial suture morphogenesis (GO:0097094)5.00288472
38cardiac muscle cell proliferation (GO:0060038)4.93101722
39branching involved in salivary gland morphogenesis (GO:0060445)4.90350700
40positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.88750482
41limb development (GO:0060173)4.85296974
42appendage development (GO:0048736)4.85296974
43regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.80180756
44gland morphogenesis (GO:0022612)4.78426142
45cell proliferation involved in kidney development (GO:0072111)4.76496115
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.75534112
47mesenchymal cell proliferation (GO:0010463)4.72679307
48dopamine biosynthetic process (GO:0042416)4.69955676
49keratinocyte proliferation (GO:0043616)4.65121913
50glomerular visceral epithelial cell development (GO:0072015)4.60042555
51regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.58304750
52positive regulation of T cell apoptotic process (GO:0070234)4.57663578
53regulation of non-canonical Wnt signaling pathway (GO:2000050)4.52833530
54regulation of macrophage cytokine production (GO:0010935)4.52553683
55embryonic digestive tract development (GO:0048566)4.50507870
56regulation of heart morphogenesis (GO:2000826)4.49062533
57dorsal/ventral axis specification (GO:0009950)4.23452018
58cellular response to vitamin D (GO:0071305)4.22388639
59muscle cell migration (GO:0014812)4.21233203
60smooth muscle cell differentiation (GO:0051145)4.19762774
61radial glial cell differentiation (GO:0060019)4.19550827
62striated muscle cell proliferation (GO:0014855)4.13419885
63cranial suture morphogenesis (GO:0060363)4.12856035
64neural crest cell development (GO:0014032)4.11102770
65positive regulation of embryonic development (GO:0040019)4.10233057
66positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)4.08189045
67prostate gland epithelium morphogenesis (GO:0060740)4.05752892
68neurogenesis (GO:0022008)4.04531797
69renal system development (GO:0072001)4.03927025
70negative regulation of osteoblast proliferation (GO:0033689)4.03575029
71glomerular epithelial cell development (GO:0072310)4.00728482
72skeletal muscle tissue development (GO:0007519)3.94649561
73protein heterotrimerization (GO:0070208)3.94189994
74branching involved in labyrinthine layer morphogenesis (GO:0060670)3.93604889
75thyroid gland development (GO:0030878)3.90562534
76negative regulation of catenin import into nucleus (GO:0035414)3.86984693
77aorta morphogenesis (GO:0035909)3.83901020
78positive regulation of kidney development (GO:0090184)3.83878441
79negative regulation of kidney development (GO:0090185)3.82301841
80pathway-restricted SMAD protein phosphorylation (GO:0060389)3.80909956
81mesenchymal cell development (GO:0014031)3.79121038
82glomerular basement membrane development (GO:0032836)3.71336714
83Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.70989767
84neuron fate specification (GO:0048665)3.68517872
85somatic stem cell division (GO:0048103)3.68087422
86middle ear morphogenesis (GO:0042474)3.67183760
87collagen catabolic process (GO:0030574)3.62193993
88axis elongation (GO:0003401)3.60104333
89somite development (GO:0061053)3.58380244
90maternal placenta development (GO:0001893)3.58056616
91digestive tract morphogenesis (GO:0048546)3.56393991
92limb bud formation (GO:0060174)3.56375992
93odontogenesis of dentin-containing tooth (GO:0042475)3.55911737
94regulation of establishment of planar polarity (GO:0090175)3.55187040
95azole transport (GO:0045117)3.55111756
96outer ear morphogenesis (GO:0042473)3.53848955
97collagen metabolic process (GO:0032963)3.53201024
98convergent extension (GO:0060026)3.52749817
99branch elongation of an epithelium (GO:0060602)3.52359536
100collagen fibril organization (GO:0030199)3.50102459
101regulation of hair cycle (GO:0042634)3.46381418
102lung-associated mesenchyme development (GO:0060484)3.46290467
103hair follicle morphogenesis (GO:0031069)3.46057235
104multicellular organismal catabolic process (GO:0044243)3.45898021
105positive regulation of neutrophil migration (GO:1902624)3.43350057
106positive regulation of neutrophil chemotaxis (GO:0090023)3.43350057
107multicellular organismal macromolecule metabolic process (GO:0044259)3.42924141
108sequestering of extracellular ligand from receptor (GO:0035581)3.41647214
109odontogenesis (GO:0042476)3.40681895
110regulation of extracellular matrix disassembly (GO:0010715)3.38253038
111non-canonical Wnt signaling pathway (GO:0035567)3.36234743
112positive regulation of mesonephros development (GO:0061213)3.35651490
113otic vesicle formation (GO:0030916)3.35541133
114regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.33352899
115positive regulation of lymphocyte apoptotic process (GO:0070230)3.31982482
116axon extension (GO:0048675)3.30416007
117positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.30263957
118intracellular estrogen receptor signaling pathway (GO:0030520)3.30204941
119glial cell migration (GO:0008347)3.29881402
120striated muscle tissue development (GO:0014706)3.29564948
121neuron projection extension involved in neuron projection guidance (GO:1902284)3.27130996
122axon extension involved in axon guidance (GO:0048846)3.27130996
123positive regulation of gastrulation (GO:2000543)3.26998777
124extracellular matrix disassembly (GO:0022617)3.26446236
125mesodermal cell differentiation (GO:0048333)3.25581196
126negative regulation of chondrocyte differentiation (GO:0032331)3.24030383
127regulation of keratinocyte proliferation (GO:0010837)3.23984055
128outflow tract morphogenesis (GO:0003151)3.22950847
129multicellular organismal metabolic process (GO:0044236)3.22559530
130organ formation (GO:0048645)3.22323380
131embryonic cranial skeleton morphogenesis (GO:0048701)3.17632358
132regulation of morphogenesis of a branching structure (GO:0060688)3.15702170
133positive regulation of vesicle fusion (GO:0031340)3.14382526
134regulation of osteoblast proliferation (GO:0033688)3.14137474
135regulation of kidney development (GO:0090183)3.13596691
136stem cell development (GO:0048864)3.13579791
137negative regulation of osteoblast differentiation (GO:0045668)3.12980965
138chondrocyte differentiation (GO:0002062)3.10771532
139mesenchyme morphogenesis (GO:0072132)3.10647550
140cardiac epithelial to mesenchymal transition (GO:0060317)3.10637139
141hindlimb morphogenesis (GO:0035137)3.08163681
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07455598
143regulation of chondrocyte differentiation (GO:0032330)3.07356062
144organ induction (GO:0001759)3.07340080
145muscle tissue development (GO:0060537)3.06864420
146cellular response to vitamin (GO:0071295)3.06841024
147developmental induction (GO:0031128)3.05140283
148lymph vessel development (GO:0001945)3.04689772
149mesonephros development (GO:0001823)3.03811146
150lung epithelium development (GO:0060428)3.03744947
151regulation of cartilage development (GO:0061035)3.02710812
152positive regulation of granulocyte chemotaxis (GO:0071624)3.02243846
153regulation of odontogenesis (GO:0042481)3.00994738
154mesenchymal cell differentiation (GO:0048762)3.00439376
155embryonic skeletal system morphogenesis (GO:0048704)2.99367793
156biomineral tissue development (GO:0031214)2.94351507
157cellular response to prostaglandin stimulus (GO:0071379)2.91757848
158ureteric bud development (GO:0001657)2.88957725
159protein localization to cell surface (GO:0034394)2.87950830
160tonic smooth muscle contraction (GO:0014820)2.87384394
161embryonic skeletal joint morphogenesis (GO:0060272)2.87157693
162endodermal cell differentiation (GO:0035987)2.86752156
163mesonephric tubule development (GO:0072164)2.84943531
164muscle cell fate commitment (GO:0042693)2.84633590
165morphogenesis of an epithelial fold (GO:0060571)2.84561931
166chondrocyte development (GO:0002063)2.84018497
167positive regulation of mesenchymal cell proliferation (GO:0002053)2.83774438
168pharyngeal system development (GO:0060037)2.79083476
169mesonephric epithelium development (GO:0072163)2.78951833
170negative regulation of cartilage development (GO:0061037)2.77144502
171genitalia morphogenesis (GO:0035112)2.77114375
172cellular response to cholesterol (GO:0071397)2.76918372
173type B pancreatic cell development (GO:0003323)2.76636902
174G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.76416736
175regulation of organ formation (GO:0003156)2.75322047
176anatomical structure regression (GO:0060033)2.74906256
177negative regulation of fibroblast apoptotic process (GO:2000270)2.74066991
178regulation of mesenchymal cell proliferation (GO:0010464)2.73929593
179regulation of catenin import into nucleus (GO:0035412)2.73714342
180proximal/distal pattern formation (GO:0009954)2.73331656
181positive regulation of cartilage development (GO:0061036)2.72629162
182generation of neurons (GO:0048699)11.8830477
183metanephric mesenchyme development (GO:0072075)10.5941835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57137886
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.89812559
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.95613167
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.41053007
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.84830845
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.84552995
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81212115
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59260555
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.54325117
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.39254930
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33371185
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15194565
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.13794292
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06416918
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05029375
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03889202
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03889202
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.02014992
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96431836
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95881471
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.81331149
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81330396
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79483507
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.79267584
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78594221
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76907151
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.75907348
28* FUS_26573619_Chip-Seq_HEK293_Human1.75902711
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75451581
30AR_21572438_ChIP-Seq_LNCaP_Human1.74031774
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72707161
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71395852
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.71219873
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70749805
35AHR_22903824_ChIP-Seq_MCF-7_Human1.70652752
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66992307
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64971894
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.62941519
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62699438
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.61856712
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61365224
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.60034323
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59808923
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59781576
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.59366468
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58167323
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.55404692
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55402696
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.52954789
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51072130
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50609922
52CJUN_26792858_Chip-Seq_BT549_Human1.50338206
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47969407
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47807006
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.47736936
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45950916
57* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45462265
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44434396
59CLOCK_20551151_ChIP-Seq_293T_Human1.43684063
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42517709
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40304893
62TP53_18474530_ChIP-ChIP_U2OS_Human1.38502003
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37512257
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37512257
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37512257
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34634570
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.34184623
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.33588729
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.33407474
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33054155
71* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.32905057
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32443394
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32269690
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32105194
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.30780518
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30753906
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.30220033
78RNF2_27304074_Chip-Seq_NSC_Mouse1.29843210
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28879153
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25104914
81RXR_22108803_ChIP-Seq_LS180_Human1.23965275
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22581835
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20994071
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20994071
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20268247
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19637058
87BRD4_25478319_ChIP-Seq_HGPS_Human1.17932446
88* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17931928
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17720641
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.17349889
91CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16679968
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16391323
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16317539
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16256912
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15676820
96SOX2_20726797_ChIP-Seq_SW620_Human1.14655521
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.13672978
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.11729168
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11095497
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10158667
101* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10063197
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.09337693
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07408425
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06763498
105* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06409355
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.06308973
107BCAT_22108803_ChIP-Seq_LS180_Human1.05280352
108* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02368793
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01330736
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01324492
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00766255
112EGR1_19374776_ChIP-ChIP_THP-1_Human1.00729560
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99948624
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99542748
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99163227
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97837675
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97837675
118SMAD4_21799915_ChIP-Seq_A2780_Human0.97677340
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.96730466
120TP53_16413492_ChIP-PET_HCT116_Human0.96575042
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.96177083
122* SMAD3_21741376_ChIP-Seq_EPCs_Human0.95893372
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95860213
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95664230
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94367040
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94091785
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93780732
128KDM2B_26808549_Chip-Seq_K562_Human0.86052606
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.83513385
130E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79460895
131* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79400684
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77906437
133HTT_18923047_ChIP-ChIP_STHdh_Human0.75759303
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75632457
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75154434
136DROSHA_22980978_ChIP-Seq_HELA_Human0.73583720
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72545160
138LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71397131
139* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.70796337
140SOX9_26525672_Chip-Seq_HEART_Mouse0.70526664
141* SA1_22415368_ChIP-Seq_MEFs_Mouse0.69397071
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.69097940
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68681163
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67445187
145* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.66167017
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.65741023
147SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.65366933
148KDM2B_26808549_Chip-Seq_REH_Human0.64765998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.18703135
2MP0004272_abnormal_basement_membrane3.81950685
3MP0005187_abnormal_penis_morphology3.81057160
4MP0005275_abnormal_skin_tensile3.50479941
5MP0008789_abnormal_olfactory_epithelium3.35565011
6MP0000537_abnormal_urethra_morphology3.10845789
7MP0008438_abnormal_cutaneous_collagen3.07275795
8MP0002396_abnormal_hematopoietic_system2.99833957
9MP0009250_abnormal_appendicular_skeleto2.81224807
10MP0005248_abnormal_Harderian_gland2.73256626
11MP0010030_abnormal_orbit_morphology2.72606095
12MP0001299_abnormal_eye_distance/2.59780887
13MP0000566_synostosis2.57217291
14MP0002938_white_spotting2.45800786
15MP0004133_heterotaxia2.29611855
16MP0000579_abnormal_nail_morphology2.24071403
17MP0002282_abnormal_trachea_morphology2.23849826
18MP0000462_abnormal_digestive_system2.17744049
19MP0001485_abnormal_pinna_reflex2.13030868
20MP0009053_abnormal_anal_canal2.12323247
21MP0000762_abnormal_tongue_morphology2.12187665
22MP0005257_abnormal_intraocular_pressure2.09910893
23MP0002277_abnormal_respiratory_mucosa2.08570326
24MP0002108_abnormal_muscle_morphology2.03752674
25MP0005508_abnormal_skeleton_morphology2.02114693
26MP0003705_abnormal_hypodermis_morpholog1.97298097
27MP0002896_abnormal_bone_mineralization1.96531429
28MP0000428_abnormal_craniofacial_morphol1.94733219
29MP0004134_abnormal_chest_morphology1.92891300
30MP0010234_abnormal_vibrissa_follicle1.92724951
31MP0003942_abnormal_urinary_system1.88541054
32MP0006072_abnormal_retinal_apoptosis1.84864358
33MP0003935_abnormal_craniofacial_develop1.77652525
34MP0006054_spinal_hemorrhage1.77331423
35MP0000163_abnormal_cartilage_morphology1.73001634
36MP0001879_abnormal_lymphatic_vessel1.72740425
37MP0002098_abnormal_vibrissa_morphology1.72277822
38MP0003385_abnormal_body_wall1.71953241
39MP0002133_abnormal_respiratory_system1.71841429
40MP0005388_respiratory_system_phenotype1.71841429
41MP0004742_abnormal_vestibular_system1.71570341
42MP0003878_abnormal_ear_physiology1.71331901
43MP0005377_hearing/vestibular/ear_phenot1.71331901
44MP0001849_ear_inflammation1.69677906
45MP0000516_abnormal_urinary_system1.68550310
46MP0005367_renal/urinary_system_phenotyp1.68550310
47MP0002115_abnormal_skeleton_extremities1.65447433
48MP0000432_abnormal_head_morphology1.64587980
49MP0000647_abnormal_sebaceous_gland1.64284982
50MP0002116_abnormal_craniofacial_bone1.60514662
51MP0003941_abnormal_skin_development1.60332294
52MP0001661_extended_life_span1.60116491
53MP0000751_myopathy1.56279663
54MP0001293_anophthalmia1.50057609
55MP0003937_abnormal_limbs/digits/tail_de1.49697156
56MP0000427_abnormal_hair_cycle1.49038306
57MP0002109_abnormal_limb_morphology1.46375272
58MP0002932_abnormal_joint_morphology1.45740083
59MP0010678_abnormal_skin_adnexa1.42842973
60MP0003755_abnormal_palate_morphology1.41511873
61MP0002060_abnormal_skin_morphology1.39385203
62MP0000534_abnormal_ureter_morphology1.38960070
63MP0000049_abnormal_middle_ear1.38792577
64MP0001286_abnormal_eye_development1.36066413
65MP0000383_abnormal_hair_follicle1.35633535
66MP0002295_abnormal_pulmonary_circulatio1.31130793
67MP0009384_cardiac_valve_regurgitation1.30764642
68MP0005197_abnormal_uvea_morphology1.30295783
69MP0000026_abnormal_inner_ear1.27946457
70MP0001243_abnormal_dermal_layer1.27942301
71MP0010368_abnormal_lymphatic_system1.27463453
72MP0002113_abnormal_skeleton_development1.26747146
73MP0001346_abnormal_lacrimal_gland1.25495288
74MP0004147_increased_porphyrin_level1.23549377
75MP0002249_abnormal_larynx_morphology1.21240576
76MP0002233_abnormal_nose_morphology1.18630184
77MP0002234_abnormal_pharynx_morphology1.17914765
78MP0008775_abnormal_heart_ventricle1.17308306
79MP0002184_abnormal_innervation1.17144195
80MP0003938_abnormal_ear_development1.15297101
81MP0001943_abnormal_respiration1.14840029
82MP0002998_abnormal_bone_remodeling1.11230881
83MP0001502_abnormal_circadian_rhythm1.09375404
84MP0002752_abnormal_somatic_nervous1.07891572
85MP0002177_abnormal_outer_ear1.07496254
86MP0001958_emphysema1.06601793
87MP0000759_abnormal_skeletal_muscle1.05995829
88MP0003566_abnormal_cell_adhesion1.05972444
89MP0001542_abnormal_bone_strength1.05496949
90MP0002090_abnormal_vision1.03176854
91MP0000733_abnormal_muscle_development1.02879361
92MP0002085_abnormal_embryonic_tissue0.97434757
93MP0001963_abnormal_hearing_physiology0.97289255
94MP0003115_abnormal_respiratory_system0.97256196
95MP0005390_skeleton_phenotype0.95210152
96MP0009780_abnormal_chondrocyte_physiolo0.90757063
97MP0000955_abnormal_spinal_cord0.89427455
98MP0000613_abnormal_salivary_gland0.89164008
99MP0003567_abnormal_fetal_cardiomyocyte0.88913849
100MP0001340_abnormal_eyelid_morphology0.88066395
101MP0003279_aneurysm0.88024997
102MP0002009_preneoplasia0.87268448
103MP0000377_abnormal_hair_follicle0.86635707
104MP0000639_abnormal_adrenal_gland0.85856905
105MP0002089_abnormal_postnatal_growth/wei0.85612271
106MP0000538_abnormal_urinary_bladder0.84835985
107MP0003300_gastrointestinal_ulcer0.84501823
108MP0002092_abnormal_eye_morphology0.83294150
109MP0005023_abnormal_wound_healing0.81757870
110MP0002111_abnormal_tail_morphology0.80252379
111MP0005623_abnormal_meninges_morphology0.79995992
112MP0002114_abnormal_axial_skeleton0.79722068
113MP0003795_abnormal_bone_structure0.76689358
114MP0003861_abnormal_nervous_system0.76023242
115MP0005076_abnormal_cell_differentiation0.75972371
116MP0001270_distended_abdomen0.75076403
117MP0001614_abnormal_blood_vessel0.72895481
118MP0000750_abnormal_muscle_regeneration0.72331790
119MP0005381_digestive/alimentary_phenotyp0.72033606
120MP0003119_abnormal_digestive_system0.71599765
121MP0002081_perinatal_lethality0.70088771
122MP0003890_abnormal_embryonic-extraembry0.69579117
123MP0000631_abnormal_neuroendocrine_gland0.69354014
124MP0000778_abnormal_nervous_system0.68078582
125MP0005220_abnormal_exocrine_pancreas0.67949653
126MP0002102_abnormal_ear_morphology0.67233456
127MP0001216_abnormal_epidermal_layer0.66093293
128MP0001177_atelectasis0.65359774
129MP0009703_decreased_birth_body0.63594693
130MP0002925_abnormal_cardiovascular_devel0.60882346
131MP0004185_abnormal_adipocyte_glucose0.60864080
132MP0001175_abnormal_lung_morphology0.60577438
133MP0004859_abnormal_synaptic_plasticity0.59708059
134MP0005193_abnormal_anterior_eye0.59567230
135MP0002168_other_aberrant_phenotype0.58177563
136MP0004264_abnormal_extraembryonic_tissu0.58120632
137MP0001188_hyperpigmentation0.57964174
138MP0002882_abnormal_neuron_morphology0.57476278
139MP0000467_abnormal_esophagus_morphology0.52796492
140MP0000266_abnormal_heart_morphology0.50933696
141MP0004087_abnormal_muscle_fiber0.49233948
142MP0002084_abnormal_developmental_patter0.46623682
143MP0002877_abnormal_melanocyte_morpholog0.46104167
144MP0010630_abnormal_cardiac_muscle0.45965526
145MP0003879_abnormal_hair_cell0.45269595
146MP0005253_abnormal_eye_physiology0.43964429

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)8.29052830
2Lip pit (HP:0100267)7.45477049
3Vascular tortuosity (HP:0004948)7.41667129
4Spondylolisthesis (HP:0003302)7.00670656
5Calcaneovalgus deformity (HP:0001848)6.77282738
6Deformed tarsal bones (HP:0008119)5.98594372
7Abnormality of the parietal bone (HP:0002696)5.88325193
8Nausea (HP:0002018)5.64356910
9Mitral valve prolapse (HP:0001634)4.91170538
10Midline defect of the nose (HP:0004122)4.86702711
11Short 4th metacarpal (HP:0010044)4.74427592
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.74427592
13Milia (HP:0001056)4.73665649
14Atrophic scars (HP:0001075)4.59900270
15Abnormality of the calcaneus (HP:0008364)4.56370341
16Amelogenesis imperfecta (HP:0000705)4.40568981
17Broad metatarsal (HP:0001783)4.02694639
18Shallow orbits (HP:0000586)3.79859712
19Spinal cord lesions (HP:0100561)3.79084147
20Syringomyelia (HP:0003396)3.79084147
21Vitreoretinal degeneration (HP:0000655)3.77412630
22Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.75281137
23Onycholysis (HP:0001806)3.68274479
24Abnormality of the 4th metacarpal (HP:0010012)3.66817689
25Atrioventricular block (HP:0001678)3.66260297
26Trigonocephaly (HP:0000243)3.54824160
27Protrusio acetabuli (HP:0003179)3.40097807
28Bladder diverticulum (HP:0000015)3.31736101
29Down-sloping shoulders (HP:0200021)3.23682528
30Hypoplastic ischia (HP:0003175)3.20557645
31Abnormality of the distal phalanx of the thumb (HP:0009617)3.20045535
32Nasolacrimal duct obstruction (HP:0000579)3.18219704
33Peritonitis (HP:0002586)3.14824360
34Neoplasm of the heart (HP:0100544)3.12788754
35Abnormality of the diencephalon (HP:0010662)3.03554534
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.03018167
37Abnormality of the nasal septum (HP:0000419)3.00579122
38Exostoses (HP:0100777)3.00414298
39Short phalanx of the thumb (HP:0009660)2.99222664
40Periauricular skin pits (HP:0100277)2.95944757
41Preauricular pit (HP:0004467)2.95944757
42Aplasia involving bones of the extremities (HP:0009825)2.95372175
43Aplasia involving bones of the upper limbs (HP:0009823)2.95372175
44Aplasia of the phalanges of the hand (HP:0009802)2.95372175
45Coronal craniosynostosis (HP:0004440)2.90369116
46Fragile nails (HP:0001808)2.86044823
47Abnormality of the ischium (HP:0003174)2.84516920
48Genu recurvatum (HP:0002816)2.84055518
49Bicuspid aortic valve (HP:0001647)2.78727545
50Abnormality of the nasolacrimal system (HP:0000614)2.76269816
51Rectal prolapse (HP:0002035)2.72791873
52Abnormality of the lacrimal duct (HP:0011481)2.70896920
53Toxemia of pregnancy (HP:0100603)2.66006894
54Enlarged epiphyses (HP:0010580)2.64085186
55Aplasia cutis congenita (HP:0001057)2.61477089
56Partial duplication of the phalanx of hand (HP:0009999)2.60013177
57Emphysema (HP:0002097)2.58848322
58Turricephaly (HP:0000262)2.58351175
59Premature rupture of membranes (HP:0001788)2.52154196
60Epiphyseal dysplasia (HP:0002656)2.48968783
61Bell-shaped thorax (HP:0001591)2.44114177
62Broad face (HP:0000283)2.41710836
63Abnormality of the middle phalanges of the hand (HP:0009833)2.41253807
64Broad toe (HP:0001837)2.40944613
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40454476
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.38027687
67Ankle contracture (HP:0006466)2.37435573
68Abnormality of the middle phalanges of the toes (HP:0010183)2.37373552
69Hypoplastic labia majora (HP:0000059)2.36787935
70Sparse lateral eyebrow (HP:0005338)2.36571694
71Scanning speech (HP:0002168)2.35984524
72Skin pits (HP:0100276)2.33812116
73Concave nail (HP:0001598)2.33332873
74Prolonged QT interval (HP:0001657)2.33288243
75Abnormal hand bone ossification (HP:0010660)2.32362723
76Anteriorly placed anus (HP:0001545)2.32174093
77Humeroradial synostosis (HP:0003041)2.32031526
78Synostosis involving the elbow (HP:0003938)2.32031526
79Abnormality of dentin (HP:0010299)2.31387955
80Abnormal ossification of hand bones (HP:0005921)2.30812006
81Alacrima (HP:0000522)2.30323660
82Mesomelia (HP:0003027)2.27188247
83Flat capital femoral epiphysis (HP:0003370)2.27167395
84Aortic dissection (HP:0002647)2.26887463
85Supernumerary ribs (HP:0005815)2.26790395
86Broad hallux (HP:0010055)2.25953500
87Bilateral microphthalmos (HP:0007633)2.23504038
88Abnormality of the 2nd finger (HP:0004100)2.23127456
89Metaphyseal cupping (HP:0003021)2.22387059
90Follicular hyperkeratosis (HP:0007502)2.20170748
91Osteoarthritis (HP:0002758)2.18020890
92Aplasia/Hypoplasia of the lens (HP:0008063)2.16776524
93Flared metaphyses (HP:0003015)2.16098821
94Bronchomalacia (HP:0002780)2.16093996
95Absent epiphyses (HP:0010577)2.15196774
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15196774
97Partial duplication of thumb phalanx (HP:0009944)2.14903171
98Heart block (HP:0012722)2.13229496
99Abnormality of incisor morphology (HP:0011063)2.11385967
100Short middle phalanx of finger (HP:0005819)2.10816076
101Coarctation of aorta (HP:0001680)2.09935617
102Abnormality of the labia majora (HP:0012881)2.08767400
103Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.08447164
104Sprengel anomaly (HP:0000912)2.07452973
105Hypoplastic left heart (HP:0004383)2.07005038
106Neonatal short-limb short stature (HP:0008921)2.06523285
107Shawl scrotum (HP:0000049)2.06228223
108Infantile muscular hypotonia (HP:0008947)2.05447358
109Inguinal hernia (HP:0000023)2.05383912
110Abnormality of the peritoneum (HP:0002585)2.05022037
111Cubitus valgus (HP:0002967)2.05006059
112Narrow palate (HP:0000189)2.04379787
113Fragile skin (HP:0001030)2.02340864
114Recurrent corneal erosions (HP:0000495)2.01270769
115Wide anterior fontanel (HP:0000260)2.01077014
116Bowel diverticulosis (HP:0005222)1.99297249
117Short hallux (HP:0010109)1.98570516
118Synostosis of carpal bones (HP:0005048)1.97951597
119Bulbous nose (HP:0000414)1.97225715
120Supernumerary bones of the axial skeleton (HP:0009144)1.96501733
121Rhizomelia (HP:0008905)1.95801117
122Depressed nasal tip (HP:0000437)1.95572835
123Abnormality of the incisor (HP:0000676)1.95286872
124Plagiocephaly (HP:0001357)1.93329582
125Atresia of the external auditory canal (HP:0000413)1.92677188
126Abnormal atrioventricular conduction (HP:0005150)1.92393294
127Mixed hearing impairment (HP:0000410)1.91883543
128Large earlobe (HP:0009748)1.90775482
129Short palm (HP:0004279)1.90680627
130Decreased skull ossification (HP:0004331)1.89250609
131Short middle phalanx of the 5th finger (HP:0004220)1.89102956
132Microglossia (HP:0000171)1.88580449
133Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87197493
134Macroorchidism (HP:0000053)1.87069088
135Deviation of the hallux (HP:0010051)1.86241321
136Mild short stature (HP:0003502)1.84686310
137Abnormality of the pubic bones (HP:0003172)1.84245575
138Type 1 muscle fiber predominance (HP:0003803)1.83901859
139Ulnar bowing (HP:0003031)1.83357991
140Vertebral clefting (HP:0008428)1.82519573
141Short ribs (HP:0000773)1.82425395
142Soft skin (HP:0000977)1.81723795
143Abnormal number of incisors (HP:0011064)1.81614255
144Choanal stenosis (HP:0000452)1.81022058
145Skin tags (HP:0010609)1.79876029
146Hyperextensible skin (HP:0000974)1.79277684
147Preaxial foot polydactyly (HP:0001841)1.78585035
148Glossoptosis (HP:0000162)1.77711047
149Cervical subluxation (HP:0003308)1.76872054
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.75917184
151Arachnodactyly (HP:0001166)1.75608360
152Renal duplication (HP:0000075)1.75587223
153Blue sclerae (HP:0000592)1.72353817
154Preauricular skin tag (HP:0000384)1.71775851
155Abnormality of the fingertips (HP:0001211)1.71334662
156Vertebral compression fractures (HP:0002953)1.71007734
157Protuberant abdomen (HP:0001538)1.70655981
158Irregular epiphyses (HP:0010582)1.69164352
159Ectopia lentis (HP:0001083)1.69081331
160Overgrowth (HP:0001548)1.68123513
161Heterotopia (HP:0002282)1.66777508
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66400374
163Hallux valgus (HP:0001822)1.65750360
164Carpal synostosis (HP:0009702)1.65076010
165Pectus excavatum (HP:0000767)1.61607919
166Atrioventricular canal defect (HP:0006695)1.59805160
167Elbow flexion contracture (HP:0002987)1.55070020
168Hypoplastic heart (HP:0001961)1.54481171
169Round face (HP:0000311)1.51837783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.82191435
2DDR25.75322088
3FGFR24.45074106
4MKNK23.59369602
5MKNK13.33094520
6EPHB22.92235088
7EPHA22.66986737
8PIK3CA2.65217975
9EPHA32.49688620
10SIK12.48902796
11PDGFRA2.35882832
12FER2.30567375
13FGFR12.04293973
14TRIB32.02443135
15RIPK11.88967582
16STK31.87186565
17PAK61.73693334
18NUAK11.68180934
19LMTK21.65447327
20PRPF4B1.61819804
21MOS1.56327886
22MYLK1.54632416
23LATS21.52853429
24AKT31.52838799
25NLK1.49708025
26TTN1.49322465
27BMX1.48828710
28PTK61.37467475
29EPHB11.35773717
30CDK121.34532911
31DMPK1.30216736
32STK38L1.28920633
33BRD41.27792970
34NTRK31.27278161
35FRK1.26211128
36PDGFRB1.24008498
37MST1R1.22372534
38MAP3K31.20548407
39MET1.18754708
40TGFBR21.16790731
41PAK41.15000177
42PASK1.14859023
43MST41.09486057
44CDK61.09119858
45MAP3K71.05406390
46PAK21.04900392
47TGFBR11.03435457
48STK381.03100551
49ERBB41.00252308
50PKN20.99602691
51ERN10.95465424
52DYRK1A0.94487162
53TAF10.94419117
54CDK80.92509339
55PTK20.92231610
56FLT30.89790711
57TRPM70.87287606
58NTRK20.86211830
59FGFR40.84991187
60GSK3A0.81799090
61UHMK10.80290463
62CAMK1G0.77719336
63ROCK10.77155374
64CSNK1A1L0.75567573
65STK390.74897288
66PRKCE0.73961262
67RET0.73474452
68FGFR30.73448857
69PAK30.73348210
70SMG10.70819429
71ILK0.69263594
72ERBB20.68301762
73CDK30.68110370
74LRRK20.62301290
75PRKD10.61880504
76NEK20.61476161
77CAMK40.61284562
78ERBB30.59359369
79NME10.58039060
80MAPK150.57888957
81MAP2K10.55985468
82MAP3K20.55522661
83MAPK100.55245338
84MTOR0.54535805
85NTRK10.51390882
86GRK50.50408524
87CLK10.49226227
88WNK40.48281343
89PHKG20.48111470
90PHKG10.48111470
91CAMK1D0.48039923
92BMPR1B0.47921016
93MARK20.47899091
94CDC42BPA0.47619152
95PRKCI0.45632906
96STK240.44862329
97TIE10.44459454
98SGK20.43412499
99MAP2K20.43066104
100MELK0.42723978
101RPS6KL10.42047444
102RPS6KC10.42047444
103CDK50.41598831
104PRKCH0.39525105
105CDK70.39308501
106ICK0.39300590
107EEF2K0.39085799
108KSR10.38834289
109MAP3K100.38696916
110ROCK20.38335825
111CHUK0.37956096
112PRKD30.37582698
113CDK90.37414123
114CDK150.35797461
115PLK20.35711178
116IGF1R0.35464847
117MAP3K60.34958525
118ALK0.34868584
119SGK30.34214712
120MAP3K120.32330605
121CDK11A0.31903112
122TYRO30.31377084
123CDK180.31268608
124NEK90.30567019
125SRC0.30307249
126RPS6KA60.29624556
127JAK10.29508321
128WNK10.28901635
129YES10.28556039
130INSR0.27872249
131PRKG20.27812191
132AKT20.26496141
133PNCK0.25667858
134MAPK90.25214473
135HIPK20.24845537
136MAPK10.24843309
137MAPK70.24582251
138CSNK1G10.24191985
139DYRK1B0.24046450
140CSNK1D0.22767881
141MAPK80.22589055
142PDK20.21915562
143PTK2B0.21446489
144CDK20.20609334
145VRK20.19893578
146FYN0.19450635
147SGK4940.18593262
148SGK2230.18593262
149CDK10.17825604
150CDK40.17658995

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.71763134
2Basal cell carcinoma_Homo sapiens_hsa052174.64186643
3Hedgehog signaling pathway_Homo sapiens_hsa043403.90245528
4Protein digestion and absorption_Homo sapiens_hsa049743.19006278
5Focal adhesion_Homo sapiens_hsa045102.55342556
6Hippo signaling pathway_Homo sapiens_hsa043902.39570669
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28223669
8Amoebiasis_Homo sapiens_hsa051462.16631279
9Adherens junction_Homo sapiens_hsa045202.14564487
10TGF-beta signaling pathway_Homo sapiens_hsa043502.13395371
11Small cell lung cancer_Homo sapiens_hsa052222.11276342
12* Wnt signaling pathway_Homo sapiens_hsa043102.11035485
13Proteoglycans in cancer_Homo sapiens_hsa052052.02507498
14Dilated cardiomyopathy_Homo sapiens_hsa054141.78261100
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74284230
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71508463
17Melanoma_Homo sapiens_hsa052181.71148446
18Pathways in cancer_Homo sapiens_hsa052001.68907310
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51429304
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49705555
21Axon guidance_Homo sapiens_hsa043601.44438843
22Colorectal cancer_Homo sapiens_hsa052101.39776015
23Prostate cancer_Homo sapiens_hsa052151.39007788
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33148800
25Toxoplasmosis_Homo sapiens_hsa051451.31065887
26Endometrial cancer_Homo sapiens_hsa052131.30592477
27Melanogenesis_Homo sapiens_hsa049161.29344939
28Hepatitis B_Homo sapiens_hsa051611.22522366
29Tight junction_Homo sapiens_hsa045301.14300678
30Calcium signaling pathway_Homo sapiens_hsa040201.13728170
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07827492
32Selenocompound metabolism_Homo sapiens_hsa004501.07475916
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05734422
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03423212
35Bladder cancer_Homo sapiens_hsa052191.02683334
36Renin-angiotensin system_Homo sapiens_hsa046140.99670843
37Glycosaminoglycan degradation_Homo sapiens_hsa005310.99410882
38Chronic myeloid leukemia_Homo sapiens_hsa052200.97658604
39MicroRNAs in cancer_Homo sapiens_hsa052060.96358497
40Rap1 signaling pathway_Homo sapiens_hsa040150.94699855
41Cell cycle_Homo sapiens_hsa041100.92737442
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92647596
43Viral myocarditis_Homo sapiens_hsa054160.90481986
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87955983
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85209009
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85132635
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.84300455
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84089867
49Circadian entrainment_Homo sapiens_hsa047130.82392210
50Pancreatic cancer_Homo sapiens_hsa052120.81867963
51cAMP signaling pathway_Homo sapiens_hsa040240.80519046
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79518558
53Renin secretion_Homo sapiens_hsa049240.78682367
54Renal cell carcinoma_Homo sapiens_hsa052110.75084930
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73186000
56Ribosome_Homo sapiens_hsa030100.72471193
57Leishmaniasis_Homo sapiens_hsa051400.71784356
58Thyroid cancer_Homo sapiens_hsa052160.70738441
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.69933826
60Thyroid hormone synthesis_Homo sapiens_hsa049180.69921384
61Inositol phosphate metabolism_Homo sapiens_hsa005620.69897704
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69537850
63Glioma_Homo sapiens_hsa052140.69204385
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68663988
65ErbB signaling pathway_Homo sapiens_hsa040120.68491243
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.68487027
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68038076
68Estrogen signaling pathway_Homo sapiens_hsa049150.67827885
69Ras signaling pathway_Homo sapiens_hsa040140.67553150
70Long-term potentiation_Homo sapiens_hsa047200.66904618
71Lysine degradation_Homo sapiens_hsa003100.65545570
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64874341
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62243187
74Platelet activation_Homo sapiens_hsa046110.61892078
75Insulin resistance_Homo sapiens_hsa049310.61675810
76Mineral absorption_Homo sapiens_hsa049780.60421893
77Amphetamine addiction_Homo sapiens_hsa050310.60284878
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.58536137
79GnRH signaling pathway_Homo sapiens_hsa049120.58005256
80Sulfur metabolism_Homo sapiens_hsa009200.57744059
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.57690669
82Gap junction_Homo sapiens_hsa045400.55903249
83mRNA surveillance pathway_Homo sapiens_hsa030150.54948524
84Gastric acid secretion_Homo sapiens_hsa049710.54516941
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53925199
86HTLV-I infection_Homo sapiens_hsa051660.53657870
87Prolactin signaling pathway_Homo sapiens_hsa049170.52985131
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52370796
89AMPK signaling pathway_Homo sapiens_hsa041520.52131820
90MAPK signaling pathway_Homo sapiens_hsa040100.51274751
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50605833
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49976964
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48641313
94Taste transduction_Homo sapiens_hsa047420.47837321
95Endocytosis_Homo sapiens_hsa041440.47534565
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46136157
97Type II diabetes mellitus_Homo sapiens_hsa049300.45550655
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44988633
99Notch signaling pathway_Homo sapiens_hsa043300.43287020
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42981859
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42889091
102Glutamatergic synapse_Homo sapiens_hsa047240.41890653
103Morphine addiction_Homo sapiens_hsa050320.40659609
104Acute myeloid leukemia_Homo sapiens_hsa052210.39957943
105mTOR signaling pathway_Homo sapiens_hsa041500.39055904
106Dorso-ventral axis formation_Homo sapiens_hsa043200.38979082
107Oxytocin signaling pathway_Homo sapiens_hsa049210.38551194
108Glucagon signaling pathway_Homo sapiens_hsa049220.38303301
109Folate biosynthesis_Homo sapiens_hsa007900.38059421
110FoxO signaling pathway_Homo sapiens_hsa040680.35120159
111Malaria_Homo sapiens_hsa051440.34747498
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34186559
113Insulin signaling pathway_Homo sapiens_hsa049100.33876577
114Ovarian steroidogenesis_Homo sapiens_hsa049130.33691804
115Non-small cell lung cancer_Homo sapiens_hsa052230.33212706
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32843703
117Cocaine addiction_Homo sapiens_hsa050300.32401416
118Cholinergic synapse_Homo sapiens_hsa047250.31949793
119Vibrio cholerae infection_Homo sapiens_hsa051100.31562113
120Dopaminergic synapse_Homo sapiens_hsa047280.31477118
121Choline metabolism in cancer_Homo sapiens_hsa052310.31349683
122Salivary secretion_Homo sapiens_hsa049700.31112954
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.28889655
124VEGF signaling pathway_Homo sapiens_hsa043700.26901838
125Phenylalanine metabolism_Homo sapiens_hsa003600.26623378
126TNF signaling pathway_Homo sapiens_hsa046680.26592126

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