WIPI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)4.69365787
2central nervous system myelination (GO:0022010)4.63071245
3axon ensheathment in central nervous system (GO:0032291)4.63071245
4creatine metabolic process (GO:0006600)4.40231832
5negative regulation of protein localization to cell surface (GO:2000009)4.26213349
6cardiac myofibril assembly (GO:0055003)4.09484172
7muscle filament sliding (GO:0030049)3.95455776
8actin-myosin filament sliding (GO:0033275)3.95455776
9myofibril assembly (GO:0030239)3.91097912
10regulation of skeletal muscle contraction (GO:0014819)3.90687608
11plasma membrane repair (GO:0001778)3.72664311
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.65407058
13heart trabecula formation (GO:0060347)3.63290245
14extracellular fibril organization (GO:0043206)3.61341688
15regulation of integrin-mediated signaling pathway (GO:2001044)3.57478015
16myelin maintenance (GO:0043217)3.55649401
17actin-mediated cell contraction (GO:0070252)3.49561465
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.42489251
19response to hepatocyte growth factor (GO:0035728)3.38683487
20cellular response to hepatocyte growth factor stimulus (GO:0035729)3.38683487
21actomyosin structure organization (GO:0031032)3.31053860
22ensheathment of neurons (GO:0007272)3.25789788
23axon ensheathment (GO:0008366)3.25789788
24fibril organization (GO:0097435)3.24124253
25myelination (GO:0042552)3.17065285
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.14222437
27fatty acid elongation (GO:0030497)3.11543093
28calcium-mediated signaling using intracellular calcium source (GO:0035584)3.11296154
29macroautophagy (GO:0016236)3.09826148
30regulation of actin filament-based movement (GO:1903115)3.09456835
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.08779693
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.07264936
33cell migration involved in heart development (GO:0060973)3.06276671
34trabecula formation (GO:0060343)3.04554126
35protein hydroxylation (GO:0018126)3.04382401
36eye photoreceptor cell differentiation (GO:0001754)3.03674151
37photoreceptor cell differentiation (GO:0046530)3.03674151
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.00597279
39sarcoplasmic reticulum calcium ion transport (GO:0070296)3.00108835
40negative regulation of calcium ion transport into cytosol (GO:0010523)2.98902023
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.91639928
42regulation of hypersensitivity (GO:0002883)2.90938141
43cardiac muscle tissue morphogenesis (GO:0055008)2.90394557
44keratan sulfate catabolic process (GO:0042340)2.87015020
45ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.85571321
46skeletal muscle adaptation (GO:0043501)2.84152038
47response to methylmercury (GO:0051597)2.82532383
48striated muscle atrophy (GO:0014891)2.81419617
49adult heart development (GO:0007512)2.81403317
50cardiac muscle contraction (GO:0060048)2.80687942
51negative regulation of protein localization to plasma membrane (GO:1903077)2.80390529
52endocardial cushion development (GO:0003197)2.77952788
53positive regulation of macrophage differentiation (GO:0045651)2.75041847
54sequestering of extracellular ligand from receptor (GO:0035581)2.73874030
55regulation of relaxation of muscle (GO:1901077)2.73695245
56adhesion of symbiont to host cell (GO:0044650)2.72006041
57virion attachment to host cell (GO:0019062)2.72006041
58cardiac muscle cell development (GO:0055013)2.71223748
59ventricular cardiac muscle cell action potential (GO:0086005)2.71192142
60muscle tissue morphogenesis (GO:0060415)2.69614805
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.69326891
62bundle of His cell to Purkinje myocyte communication (GO:0086069)2.67924534
63negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.66975189
64negative regulation of platelet activation (GO:0010544)2.66645890
65regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.66435976
66endodermal cell differentiation (GO:0035987)2.65972478
67UDP-N-acetylglucosamine metabolic process (GO:0006047)2.64826938
68import into cell (GO:0098657)2.63701082
69regulation of membrane repolarization (GO:0060306)2.62733079
70myelination in peripheral nervous system (GO:0022011)2.62687282
71peripheral nervous system axon ensheathment (GO:0032292)2.62687282
72regulation of striated muscle contraction (GO:0006942)2.62450439
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62345512
74actin filament-based movement (GO:0030048)2.61606278
75positive regulation of receptor recycling (GO:0001921)2.60908253
76negative regulation of homotypic cell-cell adhesion (GO:0034111)2.59491623
77natural killer cell mediated cytotoxicity (GO:0042267)2.57789323
78natural killer cell mediated immunity (GO:0002228)2.57789323
79response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.56514403
80L-serine transport (GO:0015825)2.54229859
81extracellular matrix assembly (GO:0085029)2.52307548
82cardiac cell development (GO:0055006)2.51666467
83regulation of lipoprotein metabolic process (GO:0050746)2.51208709
84regulation of cell communication by electrical coupling (GO:0010649)2.50790002
85retina vasculature morphogenesis in camera-type eye (GO:0061299)2.50656884
86G-protein coupled receptor internalization (GO:0002031)2.48995290
87response to muscle activity (GO:0014850)2.48301243
88positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.48124571
89collagen fibril organization (GO:0030199)2.44476805
90tooth mineralization (GO:0034505)2.43547503
91regulation of metalloenzyme activity (GO:0048552)2.43079557
92response to redox state (GO:0051775)2.41067384
93phagocytosis, recognition (GO:0006910)2.40891780
94Golgi transport vesicle coating (GO:0048200)2.40365007
95COPI coating of Golgi vesicle (GO:0048205)2.40365007
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.39217280
97basement membrane organization (GO:0071711)2.38622919
98blood vessel maturation (GO:0001955)2.38556111
99peptidyl-proline hydroxylation (GO:0019511)2.37831147
100striated muscle contraction (GO:0006941)2.36359337
101protein heterotrimerization (GO:0070208)2.35688926
102negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.35530083
103peptidyl-tyrosine autophosphorylation (GO:0038083)2.35403373
104regulation of sequestering of triglyceride (GO:0010889)2.35262372
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.31722619
106regulation of cardioblast differentiation (GO:0051890)2.31692897
107regulation of cardiac muscle cell contraction (GO:0086004)2.31467124
1084-hydroxyproline metabolic process (GO:0019471)2.30439069
109negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.30333804
110barbed-end actin filament capping (GO:0051016)2.29870856
111membrane tubulation (GO:0097320)2.29705037
112anterior/posterior axis specification, embryo (GO:0008595)2.29651025
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.28945372
114neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.27982359
115tricarboxylic acid cycle (GO:0006099)2.27409319
116skin morphogenesis (GO:0043589)2.27125040
117negative regulation of acute inflammatory response (GO:0002674)2.26330604
118carnitine shuttle (GO:0006853)2.26097295
119astrocyte differentiation (GO:0048708)2.26077379
120regulation of cardiac muscle contraction (GO:0055117)2.25371427
121protein targeting to plasma membrane (GO:0072661)2.25089576
122positive regulation of glycogen biosynthetic process (GO:0045725)2.23459204
123acyl-CoA biosynthetic process (GO:0071616)2.22753027
124thioester biosynthetic process (GO:0035384)2.22753027
125platelet degranulation (GO:0002576)2.22705318
126bone trabecula formation (GO:0060346)2.22131445
127adhesion of symbiont to host (GO:0044406)2.22115030
128positive regulation of Rho protein signal transduction (GO:0035025)2.21741815
129skeletal muscle contraction (GO:0003009)2.21702661
130cellular response to interleukin-6 (GO:0071354)2.21055401
131decidualization (GO:0046697)2.19961845
132purine nucleotide transport (GO:0015865)2.19367519
133negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.18219281
134regulation of receptor recycling (GO:0001919)2.17655205
135muscle contraction (GO:0006936)2.16418936
136regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.16242890
137cardiac muscle hypertrophy (GO:0003300)2.16145926
138muscle atrophy (GO:0014889)2.15136907
139regulation of platelet aggregation (GO:0090330)2.13684883
140serine transport (GO:0032329)2.12961906
141fatty acid beta-oxidation (GO:0006635)2.12701796
142atrioventricular valve morphogenesis (GO:0003181)2.12588416
143protein localization to endosome (GO:0036010)2.11877223
144striated muscle hypertrophy (GO:0014897)2.11661394
145regulation of sarcomere organization (GO:0060297)2.11395475
146regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.11031796
147asymmetric protein localization (GO:0008105)2.10957576
148negative regulation of striated muscle cell apoptotic process (GO:0010664)2.10897190
149substrate-dependent cell migration (GO:0006929)2.10658819
150cellular response to epinephrine stimulus (GO:0071872)2.10507112
151astrocyte development (GO:0014002)2.10189564
152protein targeting to Golgi (GO:0000042)2.10027413
153cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.09574486
154aspartate family amino acid catabolic process (GO:0009068)2.09359221
155outflow tract septum morphogenesis (GO:0003148)2.08712765
156negative regulation of leukocyte chemotaxis (GO:0002689)2.08633368
157type B pancreatic cell proliferation (GO:0044342)2.08146689
158regulation of necroptotic process (GO:0060544)2.06844448
159maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.06010206
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.05287780
161protein maturation by protein folding (GO:0022417)2.03870653
162cell migration involved in sprouting angiogenesis (GO:0002042)2.02760235
163regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.01736162
164apoptotic cell clearance (GO:0043277)2.01699633
165regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.01634481
166negative regulation of viral entry into host cell (GO:0046597)2.01498627
167heart process (GO:0003015)2.01396711
168heart contraction (GO:0060047)2.01396711
169fibroblast migration (GO:0010761)2.01147469
170platelet dense granule organization (GO:0060155)2.01133653
171amino sugar catabolic process (GO:0046348)2.00897037
172response to magnesium ion (GO:0032026)2.00249753
173pericardium development (GO:0060039)1.99228345
174cell adhesion mediated by integrin (GO:0033627)1.97733376
175regulation of platelet activation (GO:0010543)1.96416706
176melanin biosynthetic process (GO:0042438)1.95563761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.67978273
2EP300_21415370_ChIP-Seq_HL-1_Mouse2.84793948
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51621828
4* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33249876
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23514798
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22237972
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21241304
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10496387
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96212239
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95681762
11* TBX20_22080862_ChIP-Seq_HEART_Mouse1.93723975
12* TBX20_22328084_ChIP-Seq_HEART_Mouse1.93723975
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87877475
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86699787
15CLOCK_20551151_ChIP-Seq_293T_Human1.84732684
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.83959431
17ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.80212302
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79685734
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76234514
20NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75452156
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75452156
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72098204
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.70726384
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65732755
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65732755
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.65228235
27* ESR2_21235772_ChIP-Seq_MCF-7_Human1.63208122
28* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60470381
29* ESR1_20079471_ChIP-ChIP_T-47D_Human1.60466307
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59907473
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.59697055
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58028161
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.57239717
34CJUN_26792858_Chip-Seq_BT549_Human1.49873534
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49586865
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47362663
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45357563
38* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44983879
39* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43585335
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43317592
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.43071290
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.42226039
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40267906
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39448523
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36848651
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35128307
47BRD4_25478319_ChIP-Seq_HGPS_Human1.34453261
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34020783
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.33375288
50* GATA1_19941827_ChIP-Seq_MEL_Mouse1.32400094
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32105045
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31835626
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31225783
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.27364104
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27221453
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.27053373
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.26477149
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25572551
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24854804
60DROSHA_22980978_ChIP-Seq_HELA_Human1.24292964
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23952040
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21916382
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.20701513
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19771000
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19364949
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18826126
67* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18563663
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.18547185
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18512598
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17851404
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17683212
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17415780
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.16723668
74* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15966290
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15886174
76GBX2_23144817_ChIP-Seq_PC3_Human1.15852240
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15827893
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15401954
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15240268
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14778316
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.14483962
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14321018
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13207222
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12771259
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10949716
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10727490
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10309605
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08693169
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.08519794
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.07345207
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07075904
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06852991
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06416777
94SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06282778
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05735242
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05074908
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04955459
98SOX2_20726797_ChIP-Seq_SW620_Human1.04762166
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03961146
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03655730
101GATA2_19941826_ChIP-Seq_K562_Human1.03628217
102AR_21572438_ChIP-Seq_LNCaP_Human1.03109406
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.02804664
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02040374
105EOMES_21245162_ChIP-Seq_HESCs_Human1.01926156
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99027676
107TP53_16413492_ChIP-PET_HCT116_Human0.99017751
108* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98879590
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98803790
110* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98685824
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98364114
112* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97904326
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97725137
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.97339513
115* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97167440
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96685950
117GATA1_19941826_ChIP-Seq_K562_Human0.95592870
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95448757
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95133722
120STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94313528
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.93925161
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93788491
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93345092
124RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92288653
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91906335
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91767840
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.91435603
128ATF3_27146783_Chip-Seq_COLON_Human0.90819088
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90660245
130TP53_22127205_ChIP-Seq_IMR90_Human0.90450410
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89930345
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89930345
133* SPI1_23127762_ChIP-Seq_K562_Human0.89696630
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89475345
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88789004
136TP53_18474530_ChIP-ChIP_U2OS_Human0.88692550
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88007828
138AHR_22903824_ChIP-Seq_MCF-7_Human0.87710670
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87270619
140SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86963746
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86563296
142ZNF263_19887448_ChIP-Seq_K562_Human0.85886770
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.85682707
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85666455
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84988753
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84979053
147EZH2_22144423_ChIP-Seq_EOC_Human0.84342030
148VDR_24787735_ChIP-Seq_THP-1_Human0.84212863
149SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83643561
150RUNX_20019798_ChIP-Seq_JUKART_Human0.83477592
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82603665
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.81276781
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.81248965
154GATA4_25053715_ChIP-Seq_YYC3_Human0.81202359
155EGR1_19032775_ChIP-ChIP_M12_Human0.81014461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.59623487
2MP0008438_abnormal_cutaneous_collagen4.57188789
3MP0000751_myopathy3.59805326
4MP0000749_muscle_degeneration3.18603276
5MP0004084_abnormal_cardiac_muscle3.08162012
6MP0003950_abnormal_plasma_membrane2.84538502
7MP0004036_abnormal_muscle_relaxation2.83436762
8MP0009840_abnormal_foam_cell2.56108663
9MP0005503_abnormal_tendon_morphology2.52536586
10MP0005330_cardiomyopathy2.44377040
11MP0004215_abnormal_myocardial_fiber2.40608296
12MP0005275_abnormal_skin_tensile2.40290067
13MP0003646_muscle_fatigue2.37675723
14MP0000747_muscle_weakness2.30092938
15MP0004087_abnormal_muscle_fiber2.22518818
16MP0000372_irregular_coat_pigmentation2.09478162
17MP0004145_abnormal_muscle_electrophysio2.01906474
18MP0001542_abnormal_bone_strength2.01520505
19MP0000750_abnormal_muscle_regeneration1.99069066
20MP0005083_abnormal_biliary_tract1.98982218
21MP0005464_abnormal_platelet_physiology1.95989898
22MP0002972_abnormal_cardiac_muscle1.95396246
23MP0006138_congestive_heart_failure1.94363056
24MP0004272_abnormal_basement_membrane1.92365226
25MP0005623_abnormal_meninges_morphology1.91922009
26MP0003279_aneurysm1.90995888
27MP0005620_abnormal_muscle_contractility1.88600149
28MP0000920_abnormal_myelination1.84578156
29MP0000013_abnormal_adipose_tissue1.80103442
30MP0000759_abnormal_skeletal_muscle1.79159166
31MP0004043_abnormal_pH_regulation1.79082049
32MP0009384_cardiac_valve_regurgitation1.75234873
33MP0008775_abnormal_heart_ventricle1.74252300
34MP0002106_abnormal_muscle_physiology1.73487965
35MP0002108_abnormal_muscle_morphology1.72740325
36MP0003172_abnormal_lysosome_physiology1.72509491
37MP0002269_muscular_atrophy1.70374329
38MP0005369_muscle_phenotype1.70000541
39MP0005408_hypopigmentation1.66609814
40MP0003137_abnormal_impulse_conducting1.65734265
41MP0000003_abnormal_adipose_tissue1.63829550
42MP0000371_diluted_coat_color1.60489394
43MP0005075_abnormal_melanosome_morpholog1.59775878
44MP0004130_abnormal_muscle_cell1.59061180
45MP0003705_abnormal_hypodermis_morpholog1.58115418
46MP0004233_abnormal_muscle_weight1.54076590
47MP0009780_abnormal_chondrocyte_physiolo1.53664000
48MP0001958_emphysema1.51443140
49MP0010630_abnormal_cardiac_muscle1.50586809
50MP0005385_cardiovascular_system_phenoty1.48665905
51MP0001544_abnormal_cardiovascular_syste1.48665905
52MP0003191_abnormal_cellular_cholesterol1.48021530
53MP0004510_myositis1.47086716
54MP0002877_abnormal_melanocyte_morpholog1.44847097
55MP0003724_increased_susceptibility_to1.44600419
56MP0005375_adipose_tissue_phenotype1.41965836
57MP0004484_altered_response_of1.37044699
58MP0001299_abnormal_eye_distance/1.34408171
59MP0003136_yellow_coat_color1.33548751
60MP0004185_abnormal_adipocyte_glucose1.33458545
61MP0003195_calcinosis1.33178082
62MP0005666_abnormal_adipose_tissue1.30115320
63MP0003186_abnormal_redox_activity1.28679882
64MP0003011_delayed_dark_adaptation1.28486352
65MP0004085_abnormal_heartbeat1.27257734
66MP0002254_reproductive_system_inflammat1.25090803
67MP0000733_abnormal_muscle_development1.23709957
68MP0002295_abnormal_pulmonary_circulatio1.23408829
69MP0008260_abnormal_autophagy1.22166531
70MP0002998_abnormal_bone_remodeling1.18084958
71MP0005164_abnormal_response_to1.17346422
72MP0000015_abnormal_ear_pigmentation1.16434615
73MP0005451_abnormal_body_composition1.16214420
74MP0002332_abnormal_exercise_endurance1.14273733
75MP0002148_abnormal_hypersensitivity_rea1.13472523
76MP0008004_abnormal_stomach_pH1.08400310
77MP0005023_abnormal_wound_healing1.07586356
78MP0001533_abnormal_skeleton_physiology1.06958340
79MP0009764_decreased_sensitivity_to1.05463510
80MP0005171_absent_coat_pigmentation1.05170410
81MP0000462_abnormal_digestive_system1.03918679
82MP0005670_abnormal_white_adipose1.03470057
83MP0003634_abnormal_glial_cell1.02491548
84MP0005508_abnormal_skeleton_morphology1.00836027
85MP0002896_abnormal_bone_mineralization1.00386160
86MP0003329_amyloid_beta_deposits1.00044585
87MP0009250_abnormal_appendicular_skeleto0.99956443
88MP0002933_joint_inflammation0.99354472
89MP0003283_abnormal_digestive_organ0.99072525
90MP0006082_CNS_inflammation0.92255151
91MP0006054_spinal_hemorrhage0.91186212
92MP0003828_pulmonary_edema0.90658421
93MP0003806_abnormal_nucleotide_metabolis0.88890317
94MP0003436_decreased_susceptibility_to0.88037229
95MP0010368_abnormal_lymphatic_system0.88018398
96MP0002909_abnormal_adrenal_gland0.85951765
97MP0003183_abnormal_peptide_metabolism0.83901556
98MP0004134_abnormal_chest_morphology0.83670965
99MP0005390_skeleton_phenotype0.82064044
100MP0003091_abnormal_cell_migration0.81714144
101MP0002234_abnormal_pharynx_morphology0.81246914
102MP0002132_abnormal_respiratory_system0.80801849
103MP0003300_gastrointestinal_ulcer0.80784435
104MP0003690_abnormal_glial_cell0.79345667
105MP0000762_abnormal_tongue_morphology0.77854278
106MP0000230_abnormal_systemic_arterial0.77820033
107MP0003566_abnormal_cell_adhesion0.77221075
108MP0000249_abnormal_blood_vessel0.76901778
109MP0000858_altered_metastatic_potential0.76813143
110MP0000579_abnormal_nail_morphology0.76733927
111MP0003045_fibrosis0.75892171
112MP0001243_abnormal_dermal_layer0.74426523
113MP0004885_abnormal_endolymph0.74206472
114MP0005165_increased_susceptibility_to0.73760662
115MP0005595_abnormal_vascular_smooth0.73617616
116MP0003656_abnormal_erythrocyte_physiolo0.73347821
117MP0002419_abnormal_innate_immunity0.73172221
118MP0001324_abnormal_eye_pigmentation0.71885039
119MP0005058_abnormal_lysosome_morphology0.71388808
120MP0002060_abnormal_skin_morphology0.71123429
121MP0003795_abnormal_bone_structure0.69866781
122MP0000604_amyloidosis0.69241641
123MP0006072_abnormal_retinal_apoptosis0.69058570
124MP0002127_abnormal_cardiovascular_syste0.68219692
125MP0000767_abnormal_smooth_muscle0.67885456
126MP0002128_abnormal_blood_circulation0.67619052
127MP0001661_extended_life_span0.67445521
128MP0000266_abnormal_heart_morphology0.66923062
129MP0001485_abnormal_pinna_reflex0.65469871
130MP0000163_abnormal_cartilage_morphology0.64332687
131MP0004147_increased_porphyrin_level0.62381286
132MP0003385_abnormal_body_wall0.62150993
133MP0001879_abnormal_lymphatic_vessel0.61641220
134MP0005257_abnormal_intraocular_pressure0.60954233
135MP0002090_abnormal_vision0.59343605
136MP0010386_abnormal_urinary_bladder0.55213449
137MP0000428_abnormal_craniofacial_morphol0.54616281
138MP0002168_other_aberrant_phenotype0.54494118
139MP0000343_altered_response_to0.54287597
140MP0005388_respiratory_system_phenotype0.53995591
141MP0002133_abnormal_respiratory_system0.53995591
142MP0003221_abnormal_cardiomyocyte_apopto0.53469899

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.04060283
2Premature rupture of membranes (HP:0001788)4.59387655
3Hyporeflexia of lower limbs (HP:0002600)4.49661082
4Sudden death (HP:0001699)4.21929137
5Muscle hypertrophy of the lower extremities (HP:0008968)4.20770476
6Calf muscle hypertrophy (HP:0008981)4.14036796
7Abnormality of the calf musculature (HP:0001430)3.84773987
8Exercise-induced myalgia (HP:0003738)3.83292038
9Exercise-induced muscle cramps (HP:0003710)3.78103182
10Ventricular tachycardia (HP:0004756)3.74028214
11Abnormality of liposaccharide metabolism (HP:0010968)3.66069468
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.66069468
13Abnormality of glycolipid metabolism (HP:0010969)3.66069468
14Type 1 muscle fiber predominance (HP:0003803)3.58926194
15Atrial fibrillation (HP:0005110)3.41184693
16Right ventricular cardiomyopathy (HP:0011663)3.39708795
17Protrusio acetabuli (HP:0003179)3.39175183
18Ulnar deviation of the wrist (HP:0003049)3.35390887
19Aortic aneurysm (HP:0004942)3.34794759
20Broad metatarsal (HP:0001783)3.31348408
21Vascular tortuosity (HP:0004948)3.22024844
22Lipoatrophy (HP:0100578)3.21987986
23EMG: myopathic abnormalities (HP:0003458)3.20929702
24Cervical subluxation (HP:0003308)3.20726870
25Vertebral compression fractures (HP:0002953)3.19179819
26Difficulty running (HP:0009046)3.15857100
27Primary atrial arrhythmia (HP:0001692)3.06558218
28Increased variability in muscle fiber diameter (HP:0003557)3.01750673
29Hyperinsulinemic hypoglycemia (HP:0000825)2.97752252
30Increased connective tissue (HP:0009025)2.97205473
31Distal lower limb muscle weakness (HP:0009053)2.96042118
32Myoglobinuria (HP:0002913)2.93856742
33Peritonitis (HP:0002586)2.88476894
34Dilated cardiomyopathy (HP:0001644)2.86892663
35Supraventricular tachycardia (HP:0004755)2.85726907
36Slender build (HP:0001533)2.85710561
37Supraventricular arrhythmia (HP:0005115)2.84949890
38Prolonged QT interval (HP:0001657)2.84742461
39Arterial tortuosity (HP:0005116)2.82151035
40Menorrhagia (HP:0000132)2.77965702
41Ovoid vertebral bodies (HP:0003300)2.71629115
42Spinal rigidity (HP:0003306)2.70058794
43Dysostosis multiplex (HP:0000943)2.68404617
44Hypoglycemic coma (HP:0001325)2.68253201
45Asymmetric septal hypertrophy (HP:0001670)2.66131979
46Prolonged bleeding time (HP:0003010)2.66104065
47Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.63165845
48Scapular winging (HP:0003691)2.62890435
49Abnormality of the left ventricular outflow tract (HP:0011103)2.62608590
50Subaortic stenosis (HP:0001682)2.62608590
51Muscle fiber inclusion bodies (HP:0100299)2.60727853
52Syncope (HP:0001279)2.60412249
53Gowers sign (HP:0003391)2.60158830
54Abnormality of skeletal muscle fiber size (HP:0012084)2.56250390
55Increased serum ferritin (HP:0003281)2.52273938
56Purpura (HP:0000979)2.50513553
57Pheochromocytoma (HP:0002666)2.49436661
58Spondylolisthesis (HP:0003302)2.49111037
59Hypoplastic ischia (HP:0003175)2.49080249
60Large for gestational age (HP:0001520)2.46803531
61Mildly elevated creatine phosphokinase (HP:0008180)2.46721333
62Myotonia (HP:0002486)2.45803322
63Fragile skin (HP:0001030)2.42640032
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.42558677
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42558677
66Atrophic scars (HP:0001075)2.42333228
67Round ear (HP:0100830)2.40832652
68Bundle branch block (HP:0011710)2.40366693
69Neurofibrillary tangles (HP:0002185)2.40301063
70Increased mean platelet volume (HP:0011877)2.38622232
71Distal arthrogryposis (HP:0005684)2.38517729
72Shallow orbits (HP:0000586)2.38391761
73Gingival bleeding (HP:0000225)2.35392606
74Cerebral aneurysm (HP:0004944)2.35088579
75Petechiae (HP:0000967)2.32630749
76Mitral stenosis (HP:0001718)2.31588014
77Aortic dissection (HP:0002647)2.30384048
78Ketoacidosis (HP:0001993)2.27776526
79Centrally nucleated skeletal muscle fibers (HP:0003687)2.27045379
80Myocardial infarction (HP:0001658)2.26958206
81Palpitations (HP:0001962)2.26875032
82Cardiovascular calcification (HP:0011915)2.26829296
83Abnormal platelet volume (HP:0011876)2.24073212
84Bell-shaped thorax (HP:0001591)2.23750280
85Infantile muscular hypotonia (HP:0008947)2.22721437
86Onion bulb formation (HP:0003383)2.22492262
87Nemaline bodies (HP:0003798)2.21614248
88Soft skin (HP:0000977)2.21380757
89Abnormality of the ischium (HP:0003174)2.21131778
90Abnormality of iron homeostasis (HP:0011031)2.20788672
91Neck muscle weakness (HP:0000467)2.20388515
92Foot dorsiflexor weakness (HP:0009027)2.20145931
93Difficulty climbing stairs (HP:0003551)2.19136714
94Ventricular arrhythmia (HP:0004308)2.17799091
95Abnormality of polysaccharide metabolism (HP:0011012)2.16278531
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16278531
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16278531
98Mucopolysacchariduria (HP:0008155)2.10272788
99Urinary glycosaminoglycan excretion (HP:0003541)2.10272788
100Vacuolated lymphocytes (HP:0001922)2.08318980
101Abnormality of the foot musculature (HP:0001436)2.06810861
102Aneurysm (HP:0002617)2.06776509
103Hypoplasia of the iris (HP:0007676)2.06748906
104Abnormality of transition element cation homeostasis (HP:0011030)2.05698270
105Segmental peripheral demyelination/remyelination (HP:0003481)2.05490628
106Neuroendocrine neoplasm (HP:0100634)2.03580776
107Epistaxis (HP:0000421)2.02477704
108Abnormal atrioventricular conduction (HP:0005150)2.00949296
109Muscle stiffness (HP:0003552)2.00877215
110Ankle contracture (HP:0006466)1.98645203
111Heart block (HP:0012722)1.94896707
112Hyperlipoproteinemia (HP:0010980)1.93063302
113Diaphragmatic weakness (HP:0009113)1.92506812
114Joint stiffness (HP:0001387)1.91976277
115Abnormality of macrophages (HP:0004311)1.91006787
116Aplasia of the musculature (HP:0100854)1.90922402
117Dilatation of the ascending aorta (HP:0005111)1.89114163
118Hypoglycemic seizures (HP:0002173)1.87968224
119Abnormality of dentin (HP:0010299)1.86101949
120Bladder diverticulum (HP:0000015)1.85443300
121Myopathic facies (HP:0002058)1.82760762
122Wormian bones (HP:0002645)1.82294913
123Vascular calcification (HP:0004934)1.81763092
124Spontaneous hematomas (HP:0007420)1.81211010
125Muscular dystrophy (HP:0003560)1.81149652
126Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79033273
127Hyperextensible skin (HP:0000974)1.78831798
128Distal upper limb amyotrophy (HP:0007149)1.77384488
129Upper limb amyotrophy (HP:0009129)1.77384488
130Cerebral inclusion bodies (HP:0100314)1.77142761
131Aortic regurgitation (HP:0001659)1.76771743
132Stridor (HP:0010307)1.76239313
133Abnormal gallbladder morphology (HP:0012437)1.76185749
134Hyperglycemia (HP:0003074)1.75740981
135Pancreatic islet-cell hyperplasia (HP:0004510)1.75467277
136Buphthalmos (HP:0000557)1.75364285
137Skin nodule (HP:0200036)1.74599901
138Abnormality of the neuromuscular junction (HP:0003398)1.74396471
139Fatigable weakness (HP:0003473)1.74396471
140Bruising susceptibility (HP:0000978)1.74234460
141Bradycardia (HP:0001662)1.72784365
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.72254444
143Hypoplasia of the fovea (HP:0007750)1.72254444
144Elbow flexion contracture (HP:0002987)1.71638333
145Hip contracture (HP:0003273)1.71336679
146Xanthomatosis (HP:0000991)1.71222780
147Rhabdomyolysis (HP:0003201)1.70914741
148Abnormal EKG (HP:0003115)1.70781801
149Congenital glaucoma (HP:0001087)1.70728979
150Atrioventricular block (HP:0001678)1.70638522
151Follicular hyperkeratosis (HP:0007502)1.70288795
152Ileus (HP:0002595)1.69028436
153Overgrowth (HP:0001548)1.68421432
154Hydroxyprolinuria (HP:0003080)1.67120740
155Abnormality of proline metabolism (HP:0010907)1.67120740
156Blue sclerae (HP:0000592)1.66498256
157Limb-girdle muscle atrophy (HP:0003797)1.65729361
158Aplasia involving bones of the extremities (HP:0009825)1.63454637
159Aplasia of the phalanges of the hand (HP:0009802)1.63454637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.67282601
2STK393.50241916
3TRIB33.29385456
4TIE13.02221016
5EPHB12.94693131
6MAPKAPK32.75890465
7WNK42.49101136
8LMTK22.46542616
9OBSCN2.37349411
10PHKG12.34792249
11PHKG22.34792249
12DMPK2.30821396
13MUSK2.08461835
14ADRBK22.03926081
15PIK3CA2.02247541
16TGFBR21.90034155
17PKN21.86149135
18MYLK1.83939347
19PAK31.80392869
20DDR21.78096513
21MET1.75612262
22MAP3K31.73355103
23ZAP701.69906347
24LATS11.67202043
25MAPKAPK51.63350049
26OXSR11.61072836
27PKN11.60041512
28INSRR1.56528368
29WNK11.56299712
30BCKDK1.50693205
31MAP2K31.48743285
32LIMK11.48182108
33TESK11.45797542
34CAMK1G1.44419737
35NTRK11.44059188
36GRK61.38660120
37TBK11.36503065
38PRKD11.33073271
39PDGFRA1.32681683
40CAMK2D1.30710798
41TRPM71.29796022
42SIK11.28869461
43PRKD31.28096115
44CAMK1D1.26057747
45ICK1.25549306
46GRK11.22326276
47SGK4941.17725731
48SGK2231.17725731
49BLK1.15347421
50PINK11.13396530
51ROCK21.13091608
52PDK41.12826921
53PDK31.12826921
54PDK21.11736060
55EPHA31.11264414
56NEK91.10098640
57BMX1.08533687
58IRAK30.99539240
59ABL20.98619442
60JAK10.97516335
61ADRBK10.97009763
62ILK0.96748651
63FER0.96217174
64PIM20.93956408
65FGFR20.93706829
66PRKCE0.93407788
67CDC42BPA0.92904274
68MAP3K110.91812568
69MAP3K120.91712054
70PIK3CG0.90641622
71MST40.90063645
72PTK20.87598099
73TYK20.85052538
74IRAK10.84778441
75ROCK10.84760092
76KDR0.84016240
77ERN10.83186732
78GRK50.80768327
79MAP3K50.80285455
80PTK60.77841635
81STK380.75058017
82CSK0.73343788
83MAPK150.71322698
84PTK2B0.69226107
85UHMK10.68606864
86IKBKB0.68559674
87PBK0.67390655
88TXK0.66418735
89IRAK40.65029917
90BMPR20.64771081
91PAK20.63988871
92KIT0.63280409
93MOS0.63102929
94MAP2K20.62477798
95CAMK2G0.62071839
96PDPK10.61172261
97MARK30.61101559
98MAP3K70.60429500
99PAK40.59703641
100TAOK20.59412461
101HIPK20.58727147
102CAMK2A0.58627548
103JAK30.57978448
104PDGFRB0.57192328
105FGFR40.56870236
106RET0.56617666
107PRKAA20.54761424
108EPHB20.54726078
109CAMK2B0.54684560
110BCR0.54233636
111PAK60.54047926
112MAPKAPK20.53698800
113IRAK20.52321772
114NEK60.51795329
115MAP3K10.51680255
116AKT30.51338509
117MARK20.51064808
118LATS20.49405275
119MAPK110.49068836
120PRKAA10.48365319
121RPS6KA20.48112620
122CHUK0.46536082
123JAK20.45862578
124MAP2K10.45571972
125LRRK20.44745861
126MTOR0.43849967
127KSR20.43282322
128PRKCH0.42230206
129RIPK10.41979413
130MAPK120.41349299
131DAPK30.40902542
132PRKD20.39791534
133GSK3A0.38122702
134TESK20.38083561
135DYRK1B0.37543237
136PRKACB0.37167711
137GRK70.36181321
138PRKG10.35893244
139FLT30.34842895
140NME10.32508134
141CSNK1A1L0.32188082
142SGK30.31972627
143STK38L0.31794028
144TAOK30.31106218
145PRKG20.30585572

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.92853741
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.75858168
3Fatty acid elongation_Homo sapiens_hsa000622.72627224
4Nitrogen metabolism_Homo sapiens_hsa009102.62174286
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.58395169
6Dilated cardiomyopathy_Homo sapiens_hsa054142.53086724
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49632601
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.44739482
9Propanoate metabolism_Homo sapiens_hsa006402.29216673
10Sulfur metabolism_Homo sapiens_hsa009202.26186101
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21702639
12Cardiac muscle contraction_Homo sapiens_hsa042602.17563209
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14988539
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14546334
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.98005748
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.97421704
17Protein export_Homo sapiens_hsa030601.96378719
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.95135203
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87776042
20Fatty acid metabolism_Homo sapiens_hsa012121.86109261
21Fatty acid degradation_Homo sapiens_hsa000711.79017606
22Oxidative phosphorylation_Homo sapiens_hsa001901.78040585
23Glutathione metabolism_Homo sapiens_hsa004801.76874944
24ECM-receptor interaction_Homo sapiens_hsa045121.74635455
25Butanoate metabolism_Homo sapiens_hsa006501.68377923
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64943999
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63725692
28Complement and coagulation cascades_Homo sapiens_hsa046101.62221446
29Steroid biosynthesis_Homo sapiens_hsa001001.61551705
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.59362499
31Parkinsons disease_Homo sapiens_hsa050121.58134909
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53876021
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49163898
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48197260
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45801604
36Malaria_Homo sapiens_hsa051441.45047998
37Alzheimers disease_Homo sapiens_hsa050101.41275092
38Focal adhesion_Homo sapiens_hsa045101.27836307
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21788493
40Pyruvate metabolism_Homo sapiens_hsa006201.20075506
41Arginine and proline metabolism_Homo sapiens_hsa003301.19888394
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19221326
43Platelet activation_Homo sapiens_hsa046111.19124967
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15825311
45Galactose metabolism_Homo sapiens_hsa000521.12259034
46PPAR signaling pathway_Homo sapiens_hsa033201.06011977
47Carbon metabolism_Homo sapiens_hsa012001.05958061
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05150570
49Phagosome_Homo sapiens_hsa041451.03976247
50Tight junction_Homo sapiens_hsa045301.02935419
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02159782
52Collecting duct acid secretion_Homo sapiens_hsa049661.01628651
53Ether lipid metabolism_Homo sapiens_hsa005651.01517712
54Protein digestion and absorption_Homo sapiens_hsa049741.00697688
55Hematopoietic cell lineage_Homo sapiens_hsa046400.99621939
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98344320
57Rheumatoid arthritis_Homo sapiens_hsa053230.95888699
58Mineral absorption_Homo sapiens_hsa049780.95290390
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89946669
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89167651
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.88037873
62Osteoclast differentiation_Homo sapiens_hsa043800.87157486
63Insulin secretion_Homo sapiens_hsa049110.85898745
64Renal cell carcinoma_Homo sapiens_hsa052110.84252810
65TNF signaling pathway_Homo sapiens_hsa046680.83262350
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83252973
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81765600
68Linoleic acid metabolism_Homo sapiens_hsa005910.81649282
69Vibrio cholerae infection_Homo sapiens_hsa051100.80998514
70Ovarian steroidogenesis_Homo sapiens_hsa049130.80432155
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80349773
72Staphylococcus aureus infection_Homo sapiens_hsa051500.79276679
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78128407
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.77745314
75Pertussis_Homo sapiens_hsa051330.77135102
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75222725
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75079016
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72882489
79N-Glycan biosynthesis_Homo sapiens_hsa005100.71609116
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.71533715
81Tryptophan metabolism_Homo sapiens_hsa003800.70359296
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70214370
83Shigellosis_Homo sapiens_hsa051310.70132804
84Pancreatic secretion_Homo sapiens_hsa049720.70029626
85Huntingtons disease_Homo sapiens_hsa050160.69858243
86Tuberculosis_Homo sapiens_hsa051520.69684754
87Chemical carcinogenesis_Homo sapiens_hsa052040.69106245
88Regulation of autophagy_Homo sapiens_hsa041400.68451335
89Histidine metabolism_Homo sapiens_hsa003400.67915129
90Legionellosis_Homo sapiens_hsa051340.67120902
91Insulin resistance_Homo sapiens_hsa049310.66666943
92Lysosome_Homo sapiens_hsa041420.66288697
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66146444
94Fatty acid biosynthesis_Homo sapiens_hsa000610.65547807
95Peroxisome_Homo sapiens_hsa041460.64412917
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63161032
97Amoebiasis_Homo sapiens_hsa051460.62486076
98Bladder cancer_Homo sapiens_hsa052190.61892479
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.61876976
100AMPK signaling pathway_Homo sapiens_hsa041520.61568986
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61561421
102Starch and sucrose metabolism_Homo sapiens_hsa005000.61164358
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60200782
104Sphingolipid metabolism_Homo sapiens_hsa006000.59895419
105Pentose phosphate pathway_Homo sapiens_hsa000300.59545279
106Salmonella infection_Homo sapiens_hsa051320.59070732
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57998000
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57969278
109Proteoglycans in cancer_Homo sapiens_hsa052050.57794584
110Fructose and mannose metabolism_Homo sapiens_hsa000510.57638225
111Axon guidance_Homo sapiens_hsa043600.57000299
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56054346
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55943034
114Adherens junction_Homo sapiens_hsa045200.55514221
115Dorso-ventral axis formation_Homo sapiens_hsa043200.53109010
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52221592
117Hedgehog signaling pathway_Homo sapiens_hsa043400.52201649
118Glucagon signaling pathway_Homo sapiens_hsa049220.52189334
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50382810
120Gastric acid secretion_Homo sapiens_hsa049710.50126955
121Apoptosis_Homo sapiens_hsa042100.49647788
122Cocaine addiction_Homo sapiens_hsa050300.47899928
123Viral myocarditis_Homo sapiens_hsa054160.45778114
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45652201
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44486172
126Toxoplasmosis_Homo sapiens_hsa051450.43133011
127Phenylalanine metabolism_Homo sapiens_hsa003600.42593907
128Phototransduction_Homo sapiens_hsa047440.41889624
129Type II diabetes mellitus_Homo sapiens_hsa049300.41827429
130Insulin signaling pathway_Homo sapiens_hsa049100.41245874
131Small cell lung cancer_Homo sapiens_hsa052220.40861432
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40420509
133Tyrosine metabolism_Homo sapiens_hsa003500.40228692
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39323719
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.39274076
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39205013
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.37980875
138Chemokine signaling pathway_Homo sapiens_hsa040620.37675495
139ABC transporters_Homo sapiens_hsa020100.37278141
140Hippo signaling pathway_Homo sapiens_hsa043900.37118603
141beta-Alanine metabolism_Homo sapiens_hsa004100.37106842
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36692704
143Ras signaling pathway_Homo sapiens_hsa040140.36303554
144Endocytosis_Homo sapiens_hsa041440.36193672
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35978764
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.35087864
147Arachidonic acid metabolism_Homo sapiens_hsa005900.34732559
148cAMP signaling pathway_Homo sapiens_hsa040240.34232594
149Basal cell carcinoma_Homo sapiens_hsa052170.33958977
150Bile secretion_Homo sapiens_hsa049760.33948744
151Circadian rhythm_Homo sapiens_hsa047100.32983429
152Thyroid hormone synthesis_Homo sapiens_hsa049180.32001334
153Melanogenesis_Homo sapiens_hsa049160.31514224
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31355350
155Gap junction_Homo sapiens_hsa045400.31214100
156Cholinergic synapse_Homo sapiens_hsa047250.31190061
157Fat digestion and absorption_Homo sapiens_hsa049750.31111376

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