WIPI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.01599451
2negative regulation of erythrocyte differentiation (GO:0045647)4.58117757
3viral transcription (GO:0019083)4.50551626
4CDP-diacylglycerol metabolic process (GO:0046341)4.25738500
5mitotic chromosome condensation (GO:0007076)4.22830882
6translational termination (GO:0006415)4.14576174
7vitamin transmembrane transport (GO:0035461)4.06970060
8serine family amino acid catabolic process (GO:0009071)4.03342340
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.94726204
10L-phenylalanine metabolic process (GO:0006558)3.94726204
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.92682914
12L-phenylalanine catabolic process (GO:0006559)3.92682914
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.81794884
14CDP-diacylglycerol biosynthetic process (GO:0016024)3.78677533
15regulation of early endosome to late endosome transport (GO:2000641)3.73141221
16regulation of chromatin binding (GO:0035561)3.71741525
17cysteine metabolic process (GO:0006534)3.68424623
18folic acid metabolic process (GO:0046655)3.64659487
19glycine metabolic process (GO:0006544)3.61366801
20biotin metabolic process (GO:0006768)3.61181102
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59634042
22viral life cycle (GO:0019058)3.53437889
23modulation by virus of host process (GO:0019054)3.52015551
24translational elongation (GO:0006414)3.42822589
25pentose-phosphate shunt (GO:0006098)3.41954090
26serine family amino acid metabolic process (GO:0009069)3.38958665
27folic acid transport (GO:0015884)3.35574066
28cellular protein complex disassembly (GO:0043624)3.33474790
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30965615
30modulation by symbiont of host cellular process (GO:0044068)3.27707672
313-UTR-mediated mRNA stabilization (GO:0070935)3.20781594
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18497156
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.18497156
34modulation by symbiont of host immune response (GO:0052553)3.18497156
35positive regulation by symbiont of host defense response (GO:0052509)3.18497156
36modulation by symbiont of host defense response (GO:0052031)3.18497156
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18497156
38mannose metabolic process (GO:0006013)3.15942873
39pantothenate metabolic process (GO:0015939)3.15460914
40homocysteine metabolic process (GO:0050667)3.12418087
41protein complex disassembly (GO:0043241)3.10674673
42serine family amino acid biosynthetic process (GO:0009070)3.07979932
43heterochromatin organization (GO:0070828)3.06602700
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06521910
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01857121
46heme transport (GO:0015886)3.01014932
47ribosomal small subunit assembly (GO:0000028)3.00389656
48positive regulation of Cdc42 GTPase activity (GO:0043089)2.98213210
49protein localization to endosome (GO:0036010)2.97326437
50regulation of retinoic acid receptor signaling pathway (GO:0048385)2.96745804
51histone H3-K36 demethylation (GO:0070544)2.96707250
52protein targeting to ER (GO:0045047)2.96592125
53regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96543583
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96223757
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93426676
56cotranslational protein targeting to membrane (GO:0006613)2.92155658
57L-serine metabolic process (GO:0006563)2.92031996
58cellular protein complex localization (GO:0034629)2.91805784
59sulfur amino acid catabolic process (GO:0000098)2.91534884
60negative regulation of macroautophagy (GO:0016242)2.90689027
61lung-associated mesenchyme development (GO:0060484)2.89059312
62histone H4-K12 acetylation (GO:0043983)2.88530529
63apoptotic process involved in morphogenesis (GO:0060561)2.87171772
64translational initiation (GO:0006413)2.85552348
65regulation of RNA export from nucleus (GO:0046831)2.85426425
66purine nucleobase biosynthetic process (GO:0009113)2.84261612
67response to muramyl dipeptide (GO:0032495)2.84219683
68regulation of nucleobase-containing compound transport (GO:0032239)2.83488368
69NADPH regeneration (GO:0006740)2.82893733
70establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82218614
71aromatic amino acid family catabolic process (GO:0009074)2.81562965
72negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80769963
73histone H4 deacetylation (GO:0070933)2.80139974
74regulation of cholesterol homeostasis (GO:2000188)2.79934697
75pyrimidine-containing compound transmembrane transport (GO:0072531)2.78390059
76neurotransmitter catabolic process (GO:0042135)2.77234217
77macromolecular complex disassembly (GO:0032984)2.76953342
78negative regulation of histone methylation (GO:0031061)2.72773062
79protein complex localization (GO:0031503)2.72518641
80protein localization to endoplasmic reticulum (GO:0070972)2.71514053
81iron coordination entity transport (GO:1901678)2.68438177
82G1 DNA damage checkpoint (GO:0044783)2.67815737
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67805240
84regulation of response to osmotic stress (GO:0047484)2.67024817
85regulation of leukocyte degranulation (GO:0043300)2.66590514
86DNA unwinding involved in DNA replication (GO:0006268)2.66515727
87triglyceride biosynthetic process (GO:0019432)2.66415801
88focal adhesion assembly (GO:0048041)2.66242032
89cell-substrate adherens junction assembly (GO:0007045)2.66242032
90histone H3-K9 demethylation (GO:0033169)2.65981664
91positive regulation of synapse maturation (GO:0090129)2.65786185
92vitamin transport (GO:0051180)2.65517225
93receptor recycling (GO:0001881)2.65159298
94regulation of histone H3-K9 methylation (GO:0051570)2.65116617
95modified amino acid transport (GO:0072337)2.63727388
96response to peptidoglycan (GO:0032494)2.62780908
97negative regulation of fibrinolysis (GO:0051918)2.60060659
98cellular hyperosmotic response (GO:0071474)2.60036223
99negative regulation of skeletal muscle tissue development (GO:0048642)2.59638751
100intracellular estrogen receptor signaling pathway (GO:0030520)2.59536484
101neutral lipid biosynthetic process (GO:0046460)2.59111511
102acylglycerol biosynthetic process (GO:0046463)2.59111511
103adherens junction assembly (GO:0034333)2.58558755
104regulation of actin cytoskeleton reorganization (GO:2000249)2.58219482
105amino-acid betaine metabolic process (GO:0006577)2.56776837
106cofactor transport (GO:0051181)2.56281401
107regulation of bile acid biosynthetic process (GO:0070857)2.55163022
108aromatic amino acid family metabolic process (GO:0009072)2.54107993
109mitotic G1 DNA damage checkpoint (GO:0031571)2.53280875
110alpha-amino acid catabolic process (GO:1901606)2.49601057
111regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.49270708
112mitotic G1/S transition checkpoint (GO:0044819)2.49261490
113glutamate metabolic process (GO:0006536)2.48734322
114neuromuscular process controlling posture (GO:0050884)2.48335432
115protein targeting to membrane (GO:0006612)2.47835733
116regulation of mast cell degranulation (GO:0043304)2.45583545
117stress fiber assembly (GO:0043149)2.44948509
118cortical actin cytoskeleton organization (GO:0030866)2.43872389
119cellular amino acid catabolic process (GO:0009063)2.43673886
120NADH metabolic process (GO:0006734)2.43673052
121glucose catabolic process (GO:0006007)2.42771727
122negative regulation of DNA repair (GO:0045738)2.41614276
123positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.41439376
124regulation of fibrinolysis (GO:0051917)2.40895706
125regulation of superoxide anion generation (GO:0032928)2.39285224
126histone H4-K5 acetylation (GO:0043981)2.38145599
127histone H4-K8 acetylation (GO:0043982)2.38145599
128positive regulation of protein dephosphorylation (GO:0035307)2.37112257
129regulation of translational termination (GO:0006449)2.36843062
130establishment of mitochondrion localization (GO:0051654)2.36198346
131coenzyme catabolic process (GO:0009109)2.35997558
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.35967639
133pinocytosis (GO:0006907)2.35944818
134mRNA stabilization (GO:0048255)2.35932411
135RNA stabilization (GO:0043489)2.35932411
136macroautophagy (GO:0016236)2.34896539
137epithelial cell differentiation involved in prostate gland development (GO:0060742)2.34544870
138angiogenesis involved in wound healing (GO:0060055)2.34431190
139viral protein processing (GO:0019082)2.31862577
140bile acid biosynthetic process (GO:0006699)2.31400241
141erythrocyte maturation (GO:0043249)2.31367250
142virion assembly (GO:0019068)2.30863477
143maternal placenta development (GO:0001893)2.30202843
144amino sugar catabolic process (GO:0046348)2.29928379
145regulation of regulated secretory pathway (GO:1903305)2.29653991
146zinc ion transmembrane transport (GO:0071577)2.29593465
147barbed-end actin filament capping (GO:0051016)2.29490036
148maturation of SSU-rRNA (GO:0030490)2.29355341
149protein retention in ER lumen (GO:0006621)2.28764619
150modulation by virus of host morphology or physiology (GO:0019048)2.28254281
151protoporphyrinogen IX metabolic process (GO:0046501)2.27514413
152retrograde transport, endosome to Golgi (GO:0042147)2.26359284
153histone H4-K16 acetylation (GO:0043984)2.26302681
154aspartate family amino acid catabolic process (GO:0009068)2.26146251
155fructose metabolic process (GO:0006000)2.23187582
156alpha-linolenic acid metabolic process (GO:0036109)2.22818794
157* autophagic vacuole assembly (GO:0000045)2.22029278
158acetyl-CoA metabolic process (GO:0006084)2.21893167
159S-adenosylmethionine metabolic process (GO:0046500)2.21659154
160short-chain fatty acid metabolic process (GO:0046459)2.21524881
161tyrosine metabolic process (GO:0006570)2.20514282
162lysine metabolic process (GO:0006553)2.20476281
163lysine catabolic process (GO:0006554)2.20476281
164establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.19368398
165mitochondrion transport along microtubule (GO:0047497)2.19368398
166anterior/posterior axis specification, embryo (GO:0008595)2.19358098
167glutamate secretion (GO:0014047)2.19023734
168nucleobase biosynthetic process (GO:0046112)2.18765933
169phosphate ion transmembrane transport (GO:0035435)2.18728571
170bile acid metabolic process (GO:0008206)2.17802383
171fatty-acyl-CoA biosynthetic process (GO:0046949)2.17711680
172glyoxylate metabolic process (GO:0046487)2.17621230
173kynurenine metabolic process (GO:0070189)2.17532449
174intestinal epithelial cell development (GO:0060576)2.17368093
175neuronal action potential propagation (GO:0019227)2.17364090
176triglyceride homeostasis (GO:0070328)2.17253777
177acylglycerol homeostasis (GO:0055090)2.17253777
178GMP metabolic process (GO:0046037)2.17197917
179drug transmembrane transport (GO:0006855)2.16990835
180dicarboxylic acid catabolic process (GO:0043649)2.16204224
181water-soluble vitamin biosynthetic process (GO:0042364)2.14829334
182response to methylmercury (GO:0051597)2.13785651
183alditol metabolic process (GO:0019400)2.13456907
184labyrinthine layer development (GO:0060711)2.12058654
185positive regulation of autophagy (GO:0010508)2.10710057
186response to dietary excess (GO:0002021)2.10426602
187thioester biosynthetic process (GO:0035384)2.08085806
188acyl-CoA biosynthetic process (GO:0071616)2.08085806
189long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.08043933
190bile acid and bile salt transport (GO:0015721)2.06120135
191organic acid catabolic process (GO:0016054)2.06019430
192carboxylic acid catabolic process (GO:0046395)2.06019430
193fatty acid elongation (GO:0030497)2.05911260
194water-soluble vitamin metabolic process (GO:0006767)2.04417797
195phosphate ion transport (GO:0006817)2.04199433
196apical protein localization (GO:0045176)2.01925494
197sulfur amino acid metabolic process (GO:0000096)2.01656892
198cell migration in hindbrain (GO:0021535)2.00375592
199triglyceride metabolic process (GO:0006641)1.99700148
200sulfur amino acid biosynthetic process (GO:0000097)1.99370596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.03992128
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65045936
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34347838
4VDR_21846776_ChIP-Seq_THP-1_Human2.94038959
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.90675244
6MYC_22102868_ChIP-Seq_BL_Human2.88275119
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85038961
8ZNF263_19887448_ChIP-Seq_K562_Human2.63905225
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52832513
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.52295340
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48319707
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38883955
13E2F7_22180533_ChIP-Seq_HELA_Human2.36143649
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28839737
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25526785
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.23889149
17LXR_22292898_ChIP-Seq_THP-1_Human2.23458540
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.22015038
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20220972
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17872479
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.16709524
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15016393
23TCF7_22412390_ChIP-Seq_EML_Mouse2.01222697
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99433107
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98464171
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.95832412
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92969679
28* KDM2B_26808549_Chip-Seq_DND41_Human1.88629264
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.85248444
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72344728
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72274357
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71025959
33VDR_24763502_ChIP-Seq_THP-1_Human1.70786370
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.68386962
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66519448
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66117692
37* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66046440
38CLOCK_20551151_ChIP-Seq_293T_Human1.65235077
39* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59664083
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56938714
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.54229201
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51205014
43* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51038214
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49328553
45CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44342645
46* P68_20966046_ChIP-Seq_HELA_Human1.41798154
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.41419608
48SCL_19346495_ChIP-Seq_HPC-7_Human1.36491838
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35921987
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.35884869
51* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35494148
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35204725
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35105424
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32862890
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.30885560
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30072459
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28155312
58NCOR1_26117541_ChIP-Seq_K562_Human1.27856151
59XRN2_22483619_ChIP-Seq_HELA_Human1.27788180
60MAF_26560356_Chip-Seq_TH1_Human1.27526705
61EZH2_22144423_ChIP-Seq_EOC_Human1.26940830
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26577549
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.26350847
64MAF_26560356_Chip-Seq_TH2_Human1.25612491
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.23565367
66* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23287866
67ZNF274_21170338_ChIP-Seq_K562_Hela1.22144458
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21573783
69UTX_26944678_Chip-Seq_JUKART_Human1.20175100
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20024493
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19766313
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19066570
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19026259
74* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18970557
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18340064
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17925223
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17446600
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16059566
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16043129
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15691147
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15414655
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.15072224
83CREB1_26743006_Chip-Seq_LNCaP_Human1.14555257
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13316582
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13045401
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12828957
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12593531
88REST_21632747_ChIP-Seq_MESCs_Mouse1.11952066
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11423511
90* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10991229
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10673833
92* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09979673
93TFEB_21752829_ChIP-Seq_HELA_Human1.09866750
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09254922
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09228422
96CTCF_27219007_Chip-Seq_Bcells_Human1.08913713
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08801501
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08738580
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08516705
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08516705
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08516705
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08416125
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07907853
104KDM2B_26808549_Chip-Seq_K562_Human1.05796731
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05395170
106RACK7_27058665_Chip-Seq_MCF-7_Human1.04469892
107* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04298834
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.04201532
109* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03783784
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03465603
111* BCOR_27268052_Chip-Seq_Bcells_Human1.03405744
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02587151
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01503223
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01479743
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01329144
116* REST_18959480_ChIP-ChIP_MESCs_Mouse1.01116829
117TET1_21490601_ChIP-Seq_MESCs_Mouse1.00481558
118CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99740735
119* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99559395
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99417272
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99396320
122GATA1_19941826_ChIP-Seq_K562_Human0.98657480
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98507590
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97011105
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95686313
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95292701
127ATF3_27146783_Chip-Seq_COLON_Human0.95002234
128AR_21909140_ChIP-Seq_LNCAP_Human0.94704755
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94626772
130KLF4_19829295_ChIP-Seq_ESCs_Human0.93807526
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92375840
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92359167
133TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92194331
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91972098
135FOXP1_21924763_ChIP-Seq_HESCs_Human0.89595517
136GATA1_26923725_Chip-Seq_HPCs_Mouse0.89163068
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.89151385
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88433049
139MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88299363
140* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88059057
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87641305
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87350155
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.85974137
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85582990
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84640745
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.84638344
147SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84002146
148SMC4_20622854_ChIP-Seq_HELA_Human0.83981990
149* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83951253
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82808315
151SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82805650
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82779626
153EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81886015
154TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81751967
155AR_21572438_ChIP-Seq_LNCaP_Human0.81679924
156NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.81337240
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81249698
158TET1_21451524_ChIP-Seq_MESCs_Mouse0.80827004
159EZH2_27294783_Chip-Seq_ESCs_Mouse0.80625067
160SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79599414
161EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78673633
162SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78211188
163RUNX1_27514584_Chip-Seq_MCF-7_Human0.77308766
164RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76525901
165EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76525901
166JARID2_20075857_ChIP-Seq_MESCs_Mouse0.76453340
167POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.75371004
168FOXH1_21741376_ChIP-Seq_ESCs_Human0.74925081
169DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74904565
170* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73390361
171* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72949753
172SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.72886170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.96776011
2MP0002139_abnormal_hepatobiliary_system3.25513696
3MP0010030_abnormal_orbit_morphology2.93138623
4MP0005085_abnormal_gallbladder_physiolo2.83576759
5MP0005360_urolithiasis2.81607832
6MP0005058_abnormal_lysosome_morphology2.80879352
7MP0003283_abnormal_digestive_organ2.75780578
8MP0005365_abnormal_bile_salt2.69165441
9MP0010234_abnormal_vibrissa_follicle2.68070643
10MP0009278_abnormal_bone_marrow2.63007364
11MP0002877_abnormal_melanocyte_morpholog2.43175872
12MP0009840_abnormal_foam_cell2.39240863
13MP0005076_abnormal_cell_differentiation2.30855170
14MP0008260_abnormal_autophagy2.19677556
15MP0003329_amyloid_beta_deposits2.15303620
16MP0002396_abnormal_hematopoietic_system2.15261856
17MP0005409_darkened_coat_color2.08861523
18MP0000015_abnormal_ear_pigmentation2.07388073
19MP0004270_analgesia2.06728521
20MP0003172_abnormal_lysosome_physiology2.04912199
21MP0004859_abnormal_synaptic_plasticity2.03299764
22MP0005332_abnormal_amino_acid1.96704235
23MP0002254_reproductive_system_inflammat1.95428761
24MP0003111_abnormal_nucleus_morphology1.90328648
25MP0008875_abnormal_xenobiotic_pharmacok1.87348525
26MP0002089_abnormal_postnatal_growth/wei1.86705812
27MP0003136_yellow_coat_color1.83418529
28MP0003183_abnormal_peptide_metabolism1.82623046
29MP0003303_peritoneal_inflammation1.73386384
30MP0010329_abnormal_lipoprotein_level1.72167515
31MP0001545_abnormal_hematopoietic_system1.71664739
32MP0005397_hematopoietic_system_phenotyp1.71664739
33MP0004019_abnormal_vitamin_homeostasis1.67094959
34MP0003453_abnormal_keratinocyte_physiol1.63308771
35MP0004381_abnormal_hair_follicle1.62150547
36MP0003566_abnormal_cell_adhesion1.59590130
37MP0004885_abnormal_endolymph1.57934924
38MP0002822_catalepsy1.48209942
39MP0000350_abnormal_cell_proliferation1.47845646
40MP0001666_abnormal_nutrient_absorption1.46786461
41MP0001661_extended_life_span1.46225757
42MP0000013_abnormal_adipose_tissue1.46020129
43MP0003195_calcinosis1.45036802
44MP0005083_abnormal_biliary_tract1.43094442
45MP0002234_abnormal_pharynx_morphology1.42669446
46MP0001851_eye_inflammation1.42440260
47MP0005377_hearing/vestibular/ear_phenot1.41006494
48MP0003878_abnormal_ear_physiology1.41006494
49MP0001730_embryonic_growth_arrest1.39655918
50MP0005501_abnormal_skin_physiology1.37209468
51MP0002653_abnormal_ependyma_morphology1.36502283
52MP0003718_maternal_effect1.35431257
53MP0003635_abnormal_synaptic_transmissio1.35279499
54MP0003252_abnormal_bile_duct1.33817145
55MP0001348_abnormal_lacrimal_gland1.32732753
56MP0009333_abnormal_splenocyte_physiolog1.32712905
57MP0003077_abnormal_cell_cycle1.30822585
58MP0002734_abnormal_mechanical_nocicepti1.30100228
59MP0009053_abnormal_anal_canal1.29618629
60MP0002249_abnormal_larynx_morphology1.28639844
61MP0006292_abnormal_olfactory_placode1.28049554
62MP0002118_abnormal_lipid_homeostasis1.27449818
63MP0001849_ear_inflammation1.26490022
64MP0002796_impaired_skin_barrier1.25252708
65MP0003123_paternal_imprinting1.24474229
66MP0000462_abnormal_digestive_system1.22978498
67MP0003828_pulmonary_edema1.22953505
68MP0005464_abnormal_platelet_physiology1.21469770
69MP0005174_abnormal_tail_pigmentation1.20931085
70MP0000678_abnormal_parathyroid_gland1.20453373
71MP0000566_synostosis1.18179316
72MP0003091_abnormal_cell_migration1.17638262
73MP0003806_abnormal_nucleotide_metabolis1.17106205
74MP0005171_absent_coat_pigmentation1.17105108
75MP0004233_abnormal_muscle_weight1.15158797
76MP0009046_muscle_twitch1.14718211
77MP0001756_abnormal_urination1.14336729
78MP0003436_decreased_susceptibility_to1.14192085
79MP0004043_abnormal_pH_regulation1.14013523
80MP0000747_muscle_weakness1.13958469
81MP0005257_abnormal_intraocular_pressure1.13538992
82MP0003693_abnormal_embryo_hatching1.13195674
83MP0001915_intracranial_hemorrhage1.12842857
84MP0004808_abnormal_hematopoietic_stem1.11695821
85MP0000858_altered_metastatic_potential1.08769184
86MP0008438_abnormal_cutaneous_collagen1.07077889
87MP0002272_abnormal_nervous_system1.06717694
88MP0004272_abnormal_basement_membrane1.06686301
89MP0003119_abnormal_digestive_system1.05650522
90MP0001440_abnormal_grooming_behavior1.05294462
91MP0005023_abnormal_wound_healing1.04468420
92MP0002132_abnormal_respiratory_system1.03548010
93MP0000428_abnormal_craniofacial_morphol1.03304502
94MP0005621_abnormal_cell_physiology1.02890322
95MP0002064_seizures1.02299884
96MP0000537_abnormal_urethra_morphology1.01196501
97MP0001346_abnormal_lacrimal_gland0.99630822
98MP0009384_cardiac_valve_regurgitation0.99284084
99MP0002909_abnormal_adrenal_gland0.99020686
100MP0010678_abnormal_skin_adnexa0.99015771
101MP0004957_abnormal_blastocyst_morpholog0.97939543
102MP0002080_prenatal_lethality0.97865004
103MP0000313_abnormal_cell_death0.96994593
104MP0002998_abnormal_bone_remodeling0.96979608
105MP0005220_abnormal_exocrine_pancreas0.96854307
106MP0001299_abnormal_eye_distance/0.96713446
107MP0003300_gastrointestinal_ulcer0.96457470
108MP0003937_abnormal_limbs/digits/tail_de0.95525503
109MP0005408_hypopigmentation0.95070600
110MP0005394_taste/olfaction_phenotype0.94485695
111MP0005499_abnormal_olfactory_system0.94485695
112MP0000490_abnormal_crypts_of0.93503687
113MP0000534_abnormal_ureter_morphology0.93045352
114MP0001501_abnormal_sleep_pattern0.92463571
115MP0003938_abnormal_ear_development0.92026594
116MP0009672_abnormal_birth_weight0.91752100
117MP0010307_abnormal_tumor_latency0.91304409
118MP0003656_abnormal_erythrocyte_physiolo0.91259400
119MP0005248_abnormal_Harderian_gland0.90463300
120MP0003705_abnormal_hypodermis_morpholog0.89593620
121MP0002184_abnormal_innervation0.89444195
122MP0003984_embryonic_growth_retardation0.89398846
123MP0004858_abnormal_nervous_system0.89261941
124MP0002063_abnormal_learning/memory/cond0.88503718
125MP0000703_abnormal_thymus_morphology0.88438483
126MP0001672_abnormal_embryogenesis/_devel0.88270835
127MP0005380_embryogenesis_phenotype0.88270835
128MP0001968_abnormal_touch/_nociception0.87540729
129MP0005670_abnormal_white_adipose0.87310541
130MP0004947_skin_inflammation0.87257579
131MP0005451_abnormal_body_composition0.86986266
132MP0002085_abnormal_embryonic_tissue0.86895977
133MP0000955_abnormal_spinal_cord0.86830515
134MP0000778_abnormal_nervous_system0.85852536
135MP0000003_abnormal_adipose_tissue0.83877408
136MP0002088_abnormal_embryonic_growth/wei0.83188149
137MP0001697_abnormal_embryo_size0.82741109
138MP0005395_other_phenotype0.82465441
139MP0009931_abnormal_skin_appearance0.80575663
140MP0009745_abnormal_behavioral_response0.79491985
141MP0005384_cellular_phenotype0.79033695
142MP0002419_abnormal_innate_immunity0.78541972
143MP0004185_abnormal_adipocyte_glucose0.78279586
144MP0002398_abnormal_bone_marrow0.78176433
145MP0005666_abnormal_adipose_tissue0.76748655
146MP0003191_abnormal_cellular_cholesterol0.76431641
147MP0000685_abnormal_immune_system0.75993802
148MP0000604_amyloidosis0.75824891
149MP0001765_abnormal_ion_homeostasis0.75440311
150MP0001944_abnormal_pancreas_morphology0.75090881
151MP0001186_pigmentation_phenotype0.74460033
152MP0005508_abnormal_skeleton_morphology0.73727298
153MP0005375_adipose_tissue_phenotype0.73575841
154MP0002733_abnormal_thermal_nociception0.73498801
155MP0002086_abnormal_extraembryonic_tissu0.71214057
156MP0003763_abnormal_thymus_physiology0.70789140
157MP0002229_neurodegeneration0.70638570
158MP0009643_abnormal_urine_homeostasis0.70564797
159MP0001486_abnormal_startle_reflex0.70549976
160MP0002066_abnormal_motor_capabilities/c0.70425956
161MP0002075_abnormal_coat/hair_pigmentati0.70145486
162MP0002078_abnormal_glucose_homeostasis0.69104142
163MP0003690_abnormal_glial_cell0.69090053
164MP0002152_abnormal_brain_morphology0.68837309
165MP0000609_abnormal_liver_physiology0.68184234
166MP0001542_abnormal_bone_strength0.67896729
167MP0001177_atelectasis0.67870645
168MP0008789_abnormal_olfactory_epithelium0.67810621
169MP0003632_abnormal_nervous_system0.67801720
170MP0002084_abnormal_developmental_patter0.67712693
171MP0002882_abnormal_neuron_morphology0.67410411
172MP0005410_abnormal_fertilization0.66906329
173MP0000681_abnormal_thyroid_gland0.66300901
174MP0009780_abnormal_chondrocyte_physiolo0.66122097
175MP0005623_abnormal_meninges_morphology0.65700328
176MP0003861_abnormal_nervous_system0.65197816
177MP0009703_decreased_birth_body0.64912222
178MP0002269_muscular_atrophy0.64642075
179MP0000762_abnormal_tongue_morphology0.64564719
180MP0000467_abnormal_esophagus_morphology0.64325549
181MP0002067_abnormal_sensory_capabilities0.64295121
182MP0002160_abnormal_reproductive_system0.64170344
183MP0002009_preneoplasia0.63626559
184MP0003941_abnormal_skin_development0.62733608

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)4.91205622
2Hyperglycinuria (HP:0003108)4.04199982
3Abnormality of serine family amino acid metabolism (HP:0010894)4.01776095
4Abnormality of glycine metabolism (HP:0010895)4.01776095
5Hyperacusis (HP:0010780)3.74123582
6Gout (HP:0001997)3.66035740
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.45627663
8Xanthomatosis (HP:0000991)3.22438227
9Overriding aorta (HP:0002623)3.04302308
10Hyperlipoproteinemia (HP:0010980)3.00700892
11Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86890841
12Cellulitis (HP:0100658)2.86804682
13Premature rupture of membranes (HP:0001788)2.85335951
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83033184
15Protrusio acetabuli (HP:0003179)2.79322309
16Intrahepatic cholestasis (HP:0001406)2.79036652
17Vertebral compression fractures (HP:0002953)2.78547186
18Obstructive sleep apnea (HP:0002870)2.77408689
19Eczematoid dermatitis (HP:0000976)2.74364803
20Deep palmar crease (HP:0006191)2.73303493
21Hypertensive crisis (HP:0100735)2.71772369
22Shallow orbits (HP:0000586)2.70903433
23Deep venous thrombosis (HP:0002625)2.60200799
24Tetraplegia (HP:0002445)2.58624434
25Syringomyelia (HP:0003396)2.57681251
26Spinal cord lesions (HP:0100561)2.57681251
27Abnormality of serum amino acid levels (HP:0003112)2.50284091
28Bowel incontinence (HP:0002607)2.46802343
29Broad distal phalanx of finger (HP:0009836)2.46139024
30Disproportionate tall stature (HP:0001519)2.42087143
31Hyperthyroidism (HP:0000836)2.40204258
32Breast hypoplasia (HP:0003187)2.38596794
33Abnormal large intestine physiology (HP:0012700)2.37059599
34Arnold-Chiari malformation (HP:0002308)2.34313295
35Hyperammonemia (HP:0001987)2.33893556
36Partial duplication of the phalanx of hand (HP:0009999)2.33426639
37Cerebral inclusion bodies (HP:0100314)2.32437411
38Partial duplication of thumb phalanx (HP:0009944)2.32408046
39Hypoalphalipoproteinemia (HP:0003233)2.28436807
40Atelectasis (HP:0100750)2.27568826
41Ankle clonus (HP:0011448)2.27564038
42Hyperglycemia (HP:0003074)2.26546021
43Abnormality of the corticospinal tract (HP:0002492)2.26060046
44Abnormality of the lower motor neuron (HP:0002366)2.25380079
45Delusions (HP:0000746)2.24619985
46Premature skin wrinkling (HP:0100678)2.24550905
47Cerebral hypomyelination (HP:0006808)2.22402598
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22239056
49Global brain atrophy (HP:0002283)2.20297513
50Seborrheic dermatitis (HP:0001051)2.20118113
51Slow saccadic eye movements (HP:0000514)2.19662978
52Truncus arteriosus (HP:0001660)2.15453236
53Abnormality of cells of the erythroid lineage (HP:0012130)2.15293839
54Increased IgE level (HP:0003212)2.15150831
55Ketosis (HP:0001946)2.13871993
56Neurofibrillary tangles (HP:0002185)2.13479879
57Abnormality of macrophages (HP:0004311)2.11835760
58Genu recurvatum (HP:0002816)2.11012156
59Segmental peripheral demyelination/remyelination (HP:0003481)2.08363691
60Restlessness (HP:0000711)2.08320527
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.08135703
62Broad metatarsal (HP:0001783)2.08005419
63Difficulty climbing stairs (HP:0003551)2.07952788
64Patellar dislocation (HP:0002999)2.07867986
65Long palpebral fissure (HP:0000637)2.07866493
66Distal lower limb amyotrophy (HP:0008944)2.07800309
67Chronic obstructive pulmonary disease (HP:0006510)2.07696772
68Obstructive lung disease (HP:0006536)2.07696772
69Hypercortisolism (HP:0001578)2.05893986
70Termporal pattern (HP:0011008)2.04649369
71Insidious onset (HP:0003587)2.04649369
72Carpal bone hypoplasia (HP:0001498)2.04419085
73Abnormal cartilage morphology (HP:0002763)2.04274302
74Morphological abnormality of the pyramidal tract (HP:0002062)2.03849890
75Coronal craniosynostosis (HP:0004440)2.01726844
76Confusion (HP:0001289)2.01027010
77Abnormal gallbladder physiology (HP:0012438)2.00398369
78Cholecystitis (HP:0001082)2.00398369
79Abnormality of the parietal bone (HP:0002696)1.99086570
80Turricephaly (HP:0000262)1.97887520
81Cerebral aneurysm (HP:0004944)1.96811680
82Distal lower limb muscle weakness (HP:0009053)1.95367499
83Irritability (HP:0000737)1.94992714
84Degeneration of the lateral corticospinal tracts (HP:0002314)1.94870259
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94870259
86Focal seizures (HP:0007359)1.93537496
87Delayed cranial suture closure (HP:0000270)1.93442197
88Elfin facies (HP:0004428)1.93404715
89Hypolipoproteinemia (HP:0010981)1.93030203
90Abnormality of the tricuspid valve (HP:0001702)1.92514083
91Ulnar bowing (HP:0003031)1.91273092
92Spastic gait (HP:0002064)1.90982721
93Bundle branch block (HP:0011710)1.90549769
94Glucose intolerance (HP:0000833)1.89919241
95Abnormality of the thoracic spine (HP:0100711)1.88575603
96Hyperinsulinemic hypoglycemia (HP:0000825)1.87939865
97Abnormality of the Achilles tendon (HP:0005109)1.85429932
98Gastrointestinal inflammation (HP:0004386)1.82770771
99Pointed chin (HP:0000307)1.82123432
100Thoracic kyphosis (HP:0002942)1.82046022
101Status epilepticus (HP:0002133)1.81207655
102Renal duplication (HP:0000075)1.80579231
103Abnormality of glycolipid metabolism (HP:0010969)1.79941001
104Abnormality of liposaccharide metabolism (HP:0010968)1.79941001
105Abnormality of glycosphingolipid metabolism (HP:0004343)1.79941001
106Dysphonia (HP:0001618)1.79428407
107Increased connective tissue (HP:0009025)1.78905595
108Vertebral arch anomaly (HP:0008438)1.78776816
109Recurrent abscess formation (HP:0002722)1.78728124
110Dysautonomia (HP:0002459)1.78516549
111Clonus (HP:0002169)1.78293005
112Focal motor seizures (HP:0011153)1.78216798
113Abnormality of the phalanges of the hallux (HP:0010057)1.78153086
114Flat acetabular roof (HP:0003180)1.77964285
115Nuclear cataract (HP:0100018)1.77535928
116Hypoglycemic coma (HP:0001325)1.76440716
117Abnormal number of erythroid precursors (HP:0012131)1.76392846
118Ketoacidosis (HP:0001993)1.75050009
119Brushfield spots (HP:0001088)1.74588499
120Natal tooth (HP:0000695)1.74150179
121Hypobetalipoproteinemia (HP:0003563)1.74040699
122Supranuclear gaze palsy (HP:0000605)1.73711297
123Recurrent bacterial skin infections (HP:0005406)1.73530601
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.73043781
125Thrombocytosis (HP:0001894)1.72853541
126Malnutrition (HP:0004395)1.71805906
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71083693
128Dysostosis multiplex (HP:0000943)1.71042290
129Posterior subcapsular cataract (HP:0007787)1.70430480
130Neuronal loss in central nervous system (HP:0002529)1.70360544
131Ankle contracture (HP:0006466)1.69848695
132Progressive muscle weakness (HP:0003323)1.69448962
133Increased purine levels (HP:0004368)1.68578511
134Hyperuricemia (HP:0002149)1.68578511
135Abnormality of sulfur amino acid metabolism (HP:0004339)1.68578465
136CNS hypomyelination (HP:0003429)1.68479654
137Bladder diverticulum (HP:0000015)1.68191490
138Hypoglycemic seizures (HP:0002173)1.67795603
139Hypercalcemia (HP:0003072)1.67099023
140Athetosis (HP:0002305)1.66905831
141Reticulocytosis (HP:0001923)1.66222499
142Nasolacrimal duct obstruction (HP:0000579)1.65885537
143Elevated alkaline phosphatase (HP:0003155)1.65614851
144Loss of speech (HP:0002371)1.65487497
145EEG with generalized epileptiform discharges (HP:0011198)1.64998481
146Visual hallucinations (HP:0002367)1.64788262
147Ileus (HP:0002595)1.64783129
148Achilles tendon contracture (HP:0001771)1.64569584
149Upper limb amyotrophy (HP:0009129)1.64446567
150Distal upper limb amyotrophy (HP:0007149)1.64446567
151Ventricular fibrillation (HP:0001663)1.64036635
152Increased cerebral lipofuscin (HP:0011813)1.63951820
153Colitis (HP:0002583)1.63744166
154Submucous cleft hard palate (HP:0000176)1.62870055
155Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62670587
156Facial hemangioma (HP:0000329)1.62527114
157Distal sensory impairment (HP:0002936)1.61536424
158Back pain (HP:0003418)1.61394096
159Abnormality of the heme biosynthetic pathway (HP:0010472)1.61351115
160Abnormality of the fetal cardiovascular system (HP:0010948)1.61346452
161Abnormal umbilical cord blood vessels (HP:0011403)1.61346452
162Single umbilical artery (HP:0001195)1.61346452
163Abnormal enzyme/coenzyme activity (HP:0012379)1.60971467
164Increased serum ferritin (HP:0003281)1.60895494
165Hand muscle atrophy (HP:0009130)1.60883670
166Hypsarrhythmia (HP:0002521)1.60608800
167Long eyelashes (HP:0000527)1.60208451
168Myokymia (HP:0002411)1.60100161
169Thickened nuchal skin fold (HP:0000474)1.60040797
170Short nail (HP:0001799)1.59459984
171Atrioventricular block (HP:0001678)1.59209410
172Bronchomalacia (HP:0002780)1.58921114
173Shawl scrotum (HP:0000049)1.58882439
174Oligodactyly (hands) (HP:0001180)1.58404763
175Split foot (HP:0001839)1.58176553
176Ureteral duplication (HP:0000073)1.57219190
177Insomnia (HP:0100785)1.57091091
178Abnormality of the distal phalanges of the toes (HP:0010182)1.57089748
179Lethargy (HP:0001254)1.55279753
180Epileptiform EEG discharges (HP:0011182)1.54970608
181Prolonged partial thromboplastin time (HP:0003645)1.54798573
182Abnormal delivery (HP:0001787)1.53270259
183Spastic paraparesis (HP:0002313)1.53003067
184Megaloblastic anemia (HP:0001889)1.52806873
185Spastic tetraparesis (HP:0001285)1.52775329
186Spastic tetraplegia (HP:0002510)1.52331939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.79484636
2AKT33.40061329
3BUB12.94717781
4SMG12.92001615
5TAOK32.80160051
6MAP2K32.59221699
7NTRK12.55230490
8MAP3K102.54477166
9MAP3K92.42986910
10MAP3K132.41531486
11PNCK2.33565685
12KSR22.24753717
13CDK122.21340648
14LATS22.14082397
15NME21.97768763
16TLK11.97556708
17BMX1.89517492
18BCKDK1.87524720
19PAK61.77258838
20SIK11.75877772
21EEF2K1.75818567
22PRKD31.75528745
23PDK41.75375480
24PDK31.75375480
25ZAK1.73939012
26EPHA41.71335495
27EPHB21.62899989
28MAP3K21.62895937
29TAOK21.62282284
30ERN11.60369184
31ARAF1.58876785
32MAP2K21.58392080
33MAP3K111.56286123
34NTRK31.50980397
35LRRK21.50019020
36LATS11.44719354
37MARK21.43843734
38MAP3K11.42775313
39RIPK41.42382700
40MAP4K11.41902064
41STK391.40086647
42TSSK61.37095700
43PRKD21.33230123
44CDK191.33144283
45MET1.28859155
46BRAF1.28027765
47SGK2231.27928762
48SGK4941.27928762
49PDK21.27101017
50PAK31.26057540
51PRPF4B1.25003741
52WNK31.23263777
53STK381.21753163
54MAP3K41.20391558
55MAP2K11.19920816
56WEE11.15635385
57OXSR11.15288196
58WNK41.14854422
59FER1.12860976
60CDC71.10712659
61MARK31.08771516
62IRAK31.06149488
63PTK21.06135324
64ICK1.04710020
65MAP2K41.00197859
66CDK40.99483731
67RIPK10.99181272
68EPHA30.96352937
69PTK60.94360785
70PBK0.93746581
71MAP3K80.93483237
72FGR0.89710379
73FRK0.89363676
74STK160.87735365
75PINK10.87429131
76DDR20.87093034
77KSR10.86082665
78INSRR0.85947971
79CAMK2D0.85740289
80TBK10.85715404
81DAPK20.85636349
82TYK20.85485263
83ERBB40.83836195
84EPHB10.78054267
85IRAK40.77667449
86MINK10.77195188
87PAK40.77140089
88CAMK2B0.76350246
89PDGFRA0.74869191
90STK40.73432860
91CAMK2G0.73103828
92FES0.72298234
93FGFR20.71442814
94MARK10.71374457
95SGK30.71007342
96PDPK10.70417857
97PRKCG0.69692349
98MAPK120.69279094
99DYRK1B0.68712303
100MST1R0.68688653
101CSNK1E0.68394453
102CSK0.67988117
103MOS0.67454944
104BRSK10.65927662
105PASK0.65294224
106TTK0.64261558
107IRAK20.64171483
108WNK10.63629194
109CDK70.63549056
110TNK20.61575567
111CSNK1G20.60713373
112ABL20.60359167
113STK38L0.60155104
114TRIB30.60031243
115GRK60.59490707
116CAMKK10.58390901
117PRKCI0.57813881
118AURKA0.57462480
119ZAP700.56356049
120PIM10.55287395
121CSNK1G30.55152727
122NEK10.54215256
123MELK0.53652830
124CSNK1A1L0.51067143
125STK110.50892767
126PDK10.50866107
127PLK30.50850022
128ALK0.50810901
129CDK50.50807442
130* MTOR0.49183016
131CSNK1G10.48439246
132HIPK20.48140333
133MAPKAPK50.47909665
134CDK140.47652506
135MAP3K30.47394619
136SCYL20.46986114
137PRKCZ0.45425229
138RAF10.45174982
139RET0.44193162
140TESK20.43804698
141CLK10.42610160
142FGFR40.42118282
143PAK20.42092545
144TYRO30.41557009
145PRKG20.41295108
146CSF1R0.40871990
147CDK150.40042706
148EIF2AK10.39521946
149RPS6KL10.39408906
150RPS6KC10.39408906
151UHMK10.39385575
152DAPK30.39250955
153DYRK1A0.39217700
154DMPK0.39028951
155RPS6KB20.38672770
156SGK20.38533629
157MAPK100.38446943
158PRKAA10.38360797
159AKT20.38195505
160TAOK10.37656062
161PAK10.37560211
162CDK60.37518134
163HCK0.36791712
164DYRK30.36283303
165CDC42BPA0.35295578
166CDK11A0.34790665

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.15113126
2Nitrogen metabolism_Homo sapiens_hsa009103.16336500
3Ribosome_Homo sapiens_hsa030102.59690103
4Butanoate metabolism_Homo sapiens_hsa006502.57366288
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54318667
6Chronic myeloid leukemia_Homo sapiens_hsa052202.42685700
7Acute myeloid leukemia_Homo sapiens_hsa052212.36955777
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36892568
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.34458274
10Non-small cell lung cancer_Homo sapiens_hsa052232.19846426
11Other glycan degradation_Homo sapiens_hsa005112.13245051
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.06092074
13Folate biosynthesis_Homo sapiens_hsa007901.93921731
14Thyroid cancer_Homo sapiens_hsa052161.93050790
15B cell receptor signaling pathway_Homo sapiens_hsa046621.91666651
16Notch signaling pathway_Homo sapiens_hsa043301.87986056
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.87261220
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82719763
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73525674
20Pancreatic cancer_Homo sapiens_hsa052121.72137367
21VEGF signaling pathway_Homo sapiens_hsa043701.71605726
22Arginine biosynthesis_Homo sapiens_hsa002201.70261726
23Renal cell carcinoma_Homo sapiens_hsa052111.69795595
24Endometrial cancer_Homo sapiens_hsa052131.69508300
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67986265
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.64249840
27Sulfur metabolism_Homo sapiens_hsa009201.62827354
28DNA replication_Homo sapiens_hsa030301.57412382
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56164724
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53637244
31Glycerolipid metabolism_Homo sapiens_hsa005611.52157896
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.49021567
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48309934
34Glioma_Homo sapiens_hsa052141.43136117
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.38182052
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38174912
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.37609388
38Propanoate metabolism_Homo sapiens_hsa006401.36907757
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35997723
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35764934
41Sulfur relay system_Homo sapiens_hsa041221.35712197
42Colorectal cancer_Homo sapiens_hsa052101.33448771
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33427396
44Regulation of autophagy_Homo sapiens_hsa041401.32686507
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.32612339
46Vitamin digestion and absorption_Homo sapiens_hsa049771.27510571
47Fatty acid metabolism_Homo sapiens_hsa012121.27425663
48Osteoclast differentiation_Homo sapiens_hsa043801.26847748
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25913624
50Bile secretion_Homo sapiens_hsa049761.24098104
51Fatty acid degradation_Homo sapiens_hsa000711.23907457
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23569130
53Prostate cancer_Homo sapiens_hsa052151.21977611
54Biosynthesis of amino acids_Homo sapiens_hsa012301.21456871
55mRNA surveillance pathway_Homo sapiens_hsa030151.20220537
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19345437
57Synaptic vesicle cycle_Homo sapiens_hsa047211.18622600
58Tryptophan metabolism_Homo sapiens_hsa003801.17071601
59Base excision repair_Homo sapiens_hsa034101.14563461
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.13691224
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13587928
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12030120
63Phospholipase D signaling pathway_Homo sapiens_hsa040721.11691455
64Sphingolipid signaling pathway_Homo sapiens_hsa040711.09621139
65PPAR signaling pathway_Homo sapiens_hsa033201.07855260
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07580988
67Hepatitis B_Homo sapiens_hsa051611.07550575
68Selenocompound metabolism_Homo sapiens_hsa004501.06955402
69HIF-1 signaling pathway_Homo sapiens_hsa040661.06437598
70Fatty acid elongation_Homo sapiens_hsa000621.05993048
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05723213
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05245724
73Pentose phosphate pathway_Homo sapiens_hsa000301.05147141
74Vibrio cholerae infection_Homo sapiens_hsa051101.04893641
75Cell cycle_Homo sapiens_hsa041101.04046678
76Drug metabolism - other enzymes_Homo sapiens_hsa009831.02897009
77Carbon metabolism_Homo sapiens_hsa012001.02447257
78Proteoglycans in cancer_Homo sapiens_hsa052051.01717899
79Small cell lung cancer_Homo sapiens_hsa052221.00721697
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99857699
81GnRH signaling pathway_Homo sapiens_hsa049120.97840333
82Insulin secretion_Homo sapiens_hsa049110.96991803
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.96654112
84Lysosome_Homo sapiens_hsa041420.96524847
85MicroRNAs in cancer_Homo sapiens_hsa052060.95905882
86Pyruvate metabolism_Homo sapiens_hsa006200.95868617
87Fat digestion and absorption_Homo sapiens_hsa049750.95532719
88Steroid biosynthesis_Homo sapiens_hsa001000.95051557
89Insulin signaling pathway_Homo sapiens_hsa049100.91102221
90Viral carcinogenesis_Homo sapiens_hsa052030.89944432
91beta-Alanine metabolism_Homo sapiens_hsa004100.89831506
92GABAergic synapse_Homo sapiens_hsa047270.88621903
93Mismatch repair_Homo sapiens_hsa034300.88418116
94Melanogenesis_Homo sapiens_hsa049160.87712356
95mTOR signaling pathway_Homo sapiens_hsa041500.85980506
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85106143
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84123007
98Shigellosis_Homo sapiens_hsa051310.83190312
99HTLV-I infection_Homo sapiens_hsa051660.83017641
100Apoptosis_Homo sapiens_hsa042100.82902833
101FoxO signaling pathway_Homo sapiens_hsa040680.82082416
102Epstein-Barr virus infection_Homo sapiens_hsa051690.81313491
103Peroxisome_Homo sapiens_hsa041460.80948298
104Melanoma_Homo sapiens_hsa052180.80584103
105Endocytosis_Homo sapiens_hsa041440.79726861
106Prolactin signaling pathway_Homo sapiens_hsa049170.79434714
107Phenylalanine metabolism_Homo sapiens_hsa003600.79220274
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79001006
109Fructose and mannose metabolism_Homo sapiens_hsa000510.78934265
110Pathways in cancer_Homo sapiens_hsa052000.78305164
111Galactose metabolism_Homo sapiens_hsa000520.77689158
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77673426
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76966849
114Retinol metabolism_Homo sapiens_hsa008300.76447123
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.76262648
116Histidine metabolism_Homo sapiens_hsa003400.75132781
117Spliceosome_Homo sapiens_hsa030400.74599663
118Arginine and proline metabolism_Homo sapiens_hsa003300.72882331
119Choline metabolism in cancer_Homo sapiens_hsa052310.72525656
120Basal cell carcinoma_Homo sapiens_hsa052170.72115487
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71376501
122Hepatitis C_Homo sapiens_hsa051600.71201124
123Adherens junction_Homo sapiens_hsa045200.70581753
124Amoebiasis_Homo sapiens_hsa051460.70070314
125Wnt signaling pathway_Homo sapiens_hsa043100.69640774
126Lysine degradation_Homo sapiens_hsa003100.69010316
127Nicotine addiction_Homo sapiens_hsa050330.68418063
128Hedgehog signaling pathway_Homo sapiens_hsa043400.68101024
129MAPK signaling pathway_Homo sapiens_hsa040100.67639344
130Amphetamine addiction_Homo sapiens_hsa050310.67630366
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67055046
132Focal adhesion_Homo sapiens_hsa045100.66987832
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65815239
134Cocaine addiction_Homo sapiens_hsa050300.64634502
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63946424
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63095007
137Tyrosine metabolism_Homo sapiens_hsa003500.62980916
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62948168
139Rap1 signaling pathway_Homo sapiens_hsa040150.62757712
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62596019
141Bladder cancer_Homo sapiens_hsa052190.62323824
142Taste transduction_Homo sapiens_hsa047420.62206809
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61426144
144Prion diseases_Homo sapiens_hsa050200.61076481
145Chemical carcinogenesis_Homo sapiens_hsa052040.61045238
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.60411699
147Influenza A_Homo sapiens_hsa051640.57394798
148Estrogen signaling pathway_Homo sapiens_hsa049150.55814447
149Mineral absorption_Homo sapiens_hsa049780.55662189
150Tight junction_Homo sapiens_hsa045300.55222155
151Complement and coagulation cascades_Homo sapiens_hsa046100.55124063
152Salivary secretion_Homo sapiens_hsa049700.54968323
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54316350
154Oocyte meiosis_Homo sapiens_hsa041140.53702914
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53405510
156Tuberculosis_Homo sapiens_hsa051520.52874925
157Long-term potentiation_Homo sapiens_hsa047200.52654686
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52566506
159AMPK signaling pathway_Homo sapiens_hsa041520.51848489
160Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51135798
161Chemokine signaling pathway_Homo sapiens_hsa040620.50952807
162Dopaminergic synapse_Homo sapiens_hsa047280.49411847
163Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48995261
164Type II diabetes mellitus_Homo sapiens_hsa049300.48965440
165Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47778079
166Inositol phosphate metabolism_Homo sapiens_hsa005620.47716775
167Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46962002
168Collecting duct acid secretion_Homo sapiens_hsa049660.46191240
169Glucagon signaling pathway_Homo sapiens_hsa049220.45808561
170Glutamatergic synapse_Homo sapiens_hsa047240.44526091
171Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43825084
172Metabolic pathways_Homo sapiens_hsa011000.42984544
173Gap junction_Homo sapiens_hsa045400.42984030
174Thyroid hormone synthesis_Homo sapiens_hsa049180.42799988
175Glutathione metabolism_Homo sapiens_hsa004800.42655385
176Alcoholism_Homo sapiens_hsa050340.42631472
177Hippo signaling pathway_Homo sapiens_hsa043900.42592544
178ErbB signaling pathway_Homo sapiens_hsa040120.42252753
179Pancreatic secretion_Homo sapiens_hsa049720.41735435
180ABC transporters_Homo sapiens_hsa020100.41031674
181Long-term depression_Homo sapiens_hsa047300.40638086

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