WISP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)7.61563118
2chondrocyte proliferation (GO:0035988)7.28462865
3protein heterotrimerization (GO:0070208)6.36668611
4skin morphogenesis (GO:0043589)5.84168544
5sequestering of extracellular ligand from receptor (GO:0035581)5.76546007
6endodermal cell differentiation (GO:0035987)5.55520652
7bone trabecula formation (GO:0060346)5.51259450
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.90495030
9cell adhesion mediated by integrin (GO:0033627)4.79002244
10wound healing, spreading of epidermal cells (GO:0035313)4.73621052
11mesenchymal-epithelial cell signaling (GO:0060638)4.63175894
12collagen metabolic process (GO:0032963)4.59974276
13collagen catabolic process (GO:0030574)4.52013773
14cellular response to vitamin D (GO:0071305)4.46190612
15glomerular basement membrane development (GO:0032836)4.40849165
16negative regulation of fatty acid transport (GO:2000192)4.40389094
17positive regulation of endothelial cell apoptotic process (GO:2000353)4.39254427
18axon extension involved in axon guidance (GO:0048846)4.27792986
19neuron projection extension involved in neuron projection guidance (GO:1902284)4.27792986
20multicellular organismal macromolecule metabolic process (GO:0044259)4.24860901
21peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.23725538
22cellular response to vitamin (GO:0071295)4.22502577
23chondrocyte development (GO:0002063)4.11919828
24multicellular organismal catabolic process (GO:0044243)4.09446228
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.07739920
26virion attachment to host cell (GO:0019062)4.01697036
27adhesion of symbiont to host cell (GO:0044650)4.01697036
28adhesion of symbiont to host (GO:0044406)3.99980017
29multicellular organismal metabolic process (GO:0044236)3.98960838
30peptidyl-proline hydroxylation (GO:0019511)3.98818204
31dermatan sulfate biosynthetic process (GO:0030208)3.91428312
32extracellular matrix disassembly (GO:0022617)3.88729024
33craniofacial suture morphogenesis (GO:0097094)3.85040576
34wound healing, spreading of cells (GO:0044319)3.85018642
35metanephric mesenchyme development (GO:0072075)3.83966328
36extracellular fibril organization (GO:0043206)3.68523888
37blood vessel maturation (GO:0001955)3.63082333
38kidney mesenchyme development (GO:0072074)3.57375018
39substrate-dependent cell migration (GO:0006929)3.54814642
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.53372641
41negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.52561649
42fibril organization (GO:0097435)3.51481982
43dermatan sulfate metabolic process (GO:0030205)3.50674175
44positive regulation of epithelial to mesenchymal transition (GO:0010718)3.50596562
45positive regulation of blood vessel endothelial cell migration (GO:0043536)3.49776428
46epithelial cell-cell adhesion (GO:0090136)3.49226610
47negative regulation of chondrocyte differentiation (GO:0032331)3.47795722
48protein localization to cell surface (GO:0034394)3.42586897
49endocardial cushion development (GO:0003197)3.40849337
50protein retention in ER lumen (GO:0006621)3.40519510
51protein hydroxylation (GO:0018126)3.36023365
52endothelial cell morphogenesis (GO:0001886)3.35197599
53glomerular filtration (GO:0003094)3.33075095
54hippo signaling (GO:0035329)3.31215113
55positive regulation of extracellular matrix organization (GO:1903055)3.30327130
56smooth muscle tissue development (GO:0048745)3.28404357
57tooth mineralization (GO:0034505)3.28304556
58cranial suture morphogenesis (GO:0060363)3.28170260
59extracellular matrix organization (GO:0030198)3.24622569
60extracellular structure organization (GO:0043062)3.23252904
61extracellular matrix assembly (GO:0085029)3.23037098
62cell migration involved in sprouting angiogenesis (GO:0002042)3.22257908
63extracellular regulation of signal transduction (GO:1900115)3.22006857
64extracellular negative regulation of signal transduction (GO:1900116)3.22006857
65regulation of tight junction assembly (GO:2000810)3.20809493
66basement membrane organization (GO:0071711)3.19276689
67regulation of extracellular matrix disassembly (GO:0010715)3.17977255
68plasma membrane repair (GO:0001778)3.17138424
69apoptotic cell clearance (GO:0043277)3.10936546
70positive regulation of macrophage activation (GO:0043032)3.09083929
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07662238
72renal filtration (GO:0097205)3.04400378
73negative regulation of smooth muscle cell migration (GO:0014912)3.03169193
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02755148
75positive regulation of Rho protein signal transduction (GO:0035025)3.02396803
76embryonic cranial skeleton morphogenesis (GO:0048701)3.02337696
77stress fiber assembly (GO:0043149)3.00799373
78vascular endothelial growth factor signaling pathway (GO:0038084)2.99820206
79epithelial to mesenchymal transition (GO:0001837)2.99344836
80replacement ossification (GO:0036075)2.98968010
81endochondral ossification (GO:0001958)2.98968010
82cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98068155
83substrate adhesion-dependent cell spreading (GO:0034446)2.97881913
84cellular response to interferon-alpha (GO:0035457)2.96879293
85cell migration involved in heart development (GO:0060973)2.95792442
86Golgi transport vesicle coating (GO:0048200)2.94858319
87COPI coating of Golgi vesicle (GO:0048205)2.94858319
88regulation of transforming growth factor beta2 production (GO:0032909)2.93710593
89negative regulation of cartilage development (GO:0061037)2.92849490
90Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.91476586
91regulation of plasminogen activation (GO:0010755)2.89590345
92COPII vesicle coating (GO:0048208)2.89421186
93regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.89239974
94G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.88465701
95chondroitin sulfate biosynthetic process (GO:0030206)2.87138410
96positive regulation of cartilage development (GO:0061036)2.86196767
97regulation of cartilage development (GO:0061035)2.85920494
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85473095
99wound healing (GO:0042060)2.84108036
100embryonic skeletal joint morphogenesis (GO:0060272)2.83012906
101cell proliferation involved in metanephros development (GO:0072203)2.82474305
102glomerular visceral epithelial cell development (GO:0072015)2.82328526
103regulation of establishment of planar polarity (GO:0090175)2.80117385
104negative regulation of BMP signaling pathway (GO:0030514)2.79507289
105retina vasculature morphogenesis in camera-type eye (GO:0061299)2.76746541
106mesodermal cell differentiation (GO:0048333)2.76197907
107keratan sulfate catabolic process (GO:0042340)2.76152443
108type B pancreatic cell proliferation (GO:0044342)2.76020316
109muscle cell migration (GO:0014812)2.74887892
110negative regulation of embryonic development (GO:0045992)2.74152727
111endocrine hormone secretion (GO:0060986)2.73951720
112cellular response to amino acid stimulus (GO:0071230)2.73796970
113regulation of integrin-mediated signaling pathway (GO:2001044)2.71944776
114venous blood vessel morphogenesis (GO:0048845)2.71163304
115platelet-derived growth factor receptor signaling pathway (GO:0048008)2.71006324
116heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.70890752
117negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.70210127
118positive regulation of osteoblast proliferation (GO:0033690)2.68315819
119middle ear morphogenesis (GO:0042474)2.68185986
120positive regulation of fibroblast migration (GO:0010763)2.67525819
121protein targeting to plasma membrane (GO:0072661)2.67392245
122embryonic body morphogenesis (GO:0010172)2.67302402
123regulation of SMAD protein import into nucleus (GO:0060390)2.66897885
124outer ear morphogenesis (GO:0042473)2.66781461
125face morphogenesis (GO:0060325)2.64780693
126cochlea morphogenesis (GO:0090103)2.64707265
127negative chemotaxis (GO:0050919)2.64352898
128negative regulation of catenin import into nucleus (GO:0035414)2.63670057
129ossification (GO:0001503)2.62921329
130cellular response to nutrient (GO:0031670)2.62471735
131pathway-restricted SMAD protein phosphorylation (GO:0060389)2.58511705
132establishment of planar polarity (GO:0001736)2.56193636
133establishment of tissue polarity (GO:0007164)2.56193636
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.56171718
135peptide cross-linking (GO:0018149)2.54867174
136lymphangiogenesis (GO:0001946)2.53530887
137non-canonical Wnt signaling pathway (GO:0035567)2.53441835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.52495098
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.23313221
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.97972860
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.89313721
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.40550716
6* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.33825909
7WT1_19549856_ChIP-ChIP_CCG9911_Human3.08870303
8CLOCK_20551151_ChIP-Seq_293T_Human3.06074566
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88545544
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.83039690
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.80954477
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.77753911
13* CJUN_26792858_Chip-Seq_BT549_Human2.68757447
14BRD4_25478319_ChIP-Seq_HGPS_Human2.62013653
15* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.51599098
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.48521797
17NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.30431803
18NRF2_20460467_ChIP-Seq_MEFs_Mouse2.30431803
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.29368746
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.25036498
21* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.20803210
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.13206339
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.13206339
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11527103
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09275913
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.03573750
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00075366
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81427144
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73968253
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69691392
31ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.69596146
32TP53_18474530_ChIP-ChIP_U2OS_Human1.67443240
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66538185
34JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66476104
35TP53_16413492_ChIP-PET_HCT116_Human1.63342538
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.62688781
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62513628
38ATF3_27146783_Chip-Seq_COLON_Human1.62465237
39* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.62267992
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.61875352
41P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61779315
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.60618772
43* UBF1/2_26484160_Chip-Seq_HMECs_Human1.59385942
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59057020
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58173714
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.55972785
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55702836
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54586113
49TP53_22127205_ChIP-Seq_IMR90_Human1.53078748
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52459193
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48119876
52SOX2_20726797_ChIP-Seq_SW620_Human1.44597016
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44518121
54TP53_23651856_ChIP-Seq_MEFs_Mouse1.43971933
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.43200195
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42402052
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40959177
58* ELK1_22589737_ChIP-Seq_MCF10A_Human1.30689827
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29467580
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28729660
61NFI_21473784_ChIP-Seq_ESCs_Mouse1.26227043
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25356621
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24286205
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24247446
65NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23620145
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23003342
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22829375
68GBX2_23144817_ChIP-Seq_PC3_Human1.21245508
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21011718
70PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20823748
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19243248
72SA1_22415368_ChIP-Seq_MEFs_Mouse1.17944040
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17349912
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16590916
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16334658
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15788069
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15476542
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14105311
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.13398521
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12238121
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.12169017
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.12016921
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09929248
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09360679
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.07591207
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.07591207
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06631108
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05391898
89AHR_22903824_ChIP-Seq_MCF-7_Human1.05303968
90* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03966404
91* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02074987
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01409996
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00554385
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00067016
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98498639
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98373242
97WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97754307
98RACK7_27058665_Chip-Seq_MCF-7_Human0.95802912
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.95594904
100ISL1_27105846_Chip-Seq_CPCs_Mouse0.94827671
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94669617
102EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94603501
103RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94603501
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94071579
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.93877562
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92014656
107JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90841044
108RNF2_27304074_Chip-Seq_ESCs_Mouse0.90746674
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90663423
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90656127
111AR_21909140_ChIP-Seq_LNCAP_Human0.90602435
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.90515873
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90285692
114* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89377529
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88123472
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86992899
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86564781
118AR_21572438_ChIP-Seq_LNCaP_Human0.86121096
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85957465
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.85013346
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84978289
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84536596
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84516720
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83512539
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83465686
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82573366
127GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82418443
128* TP63_23658742_ChIP-Seq_EP156T_Human0.79067765
129* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78235597
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.77901636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.11136680
2MP0005503_abnormal_tendon_morphology5.06748886
3MP0005275_abnormal_skin_tensile4.82374356
4MP0003279_aneurysm3.73856429
5MP0003705_abnormal_hypodermis_morpholog3.72021509
6MP0001958_emphysema2.84803776
7MP0005623_abnormal_meninges_morphology2.78892007
8MP0001542_abnormal_bone_strength2.62898506
9MP0009384_cardiac_valve_regurgitation2.62325149
10MP0004272_abnormal_basement_membrane2.56016041
11MP0010030_abnormal_orbit_morphology2.40273825
12MP0005508_abnormal_skeleton_morphology2.38923065
13MP0003566_abnormal_cell_adhesion2.36690879
14MP0005257_abnormal_intraocular_pressure2.36161181
15MP0006054_spinal_hemorrhage2.28377594
16MP0009250_abnormal_appendicular_skeleto2.21295669
17MP0010352_gastrointestinal_tract_polyps2.01254775
18MP0002060_abnormal_skin_morphology2.00972236
19MP0005023_abnormal_wound_healing2.00482994
20MP0003091_abnormal_cell_migration1.97397490
21MP0003385_abnormal_body_wall1.89063843
22MP0002896_abnormal_bone_mineralization1.84757128
23MP0001299_abnormal_eye_distance/1.81833280
24MP0002877_abnormal_melanocyte_morpholog1.74525297
25MP0009053_abnormal_anal_canal1.73489230
26MP0001243_abnormal_dermal_layer1.67823320
27MP0002295_abnormal_pulmonary_circulatio1.60473909
28MP0000733_abnormal_muscle_development1.59519649
29MP0002108_abnormal_muscle_morphology1.54509269
30MP0002282_abnormal_trachea_morphology1.54415132
31MP0002933_joint_inflammation1.53157363
32MP0003941_abnormal_skin_development1.52050478
33MP0005390_skeleton_phenotype1.47830525
34MP0000163_abnormal_cartilage_morphology1.45075703
35MP0000767_abnormal_smooth_muscle1.43217870
36MP0004134_abnormal_chest_morphology1.42143308
37MP0002115_abnormal_skeleton_extremities1.39883453
38MP0003942_abnormal_urinary_system1.35783997
39MP0000013_abnormal_adipose_tissue1.35102155
40MP0001348_abnormal_lacrimal_gland1.32039584
41MP0003755_abnormal_palate_morphology1.25282010
42MP0002113_abnormal_skeleton_development1.24975492
43MP0000428_abnormal_craniofacial_morphol1.21222797
44MP0002932_abnormal_joint_morphology1.20481574
45MP0004858_abnormal_nervous_system1.12128830
46MP0010368_abnormal_lymphatic_system1.11657183
47MP0000750_abnormal_muscle_regeneration1.08565495
48MP0000534_abnormal_ureter_morphology1.06975102
49MP0003115_abnormal_respiratory_system1.03612893
50MP0000432_abnormal_head_morphology1.00787155
51MP0002089_abnormal_postnatal_growth/wei0.98842707
52MP0001533_abnormal_skeleton_physiology0.98078398
53MP0002998_abnormal_bone_remodeling0.97767646
54MP0002109_abnormal_limb_morphology0.96537643
55MP0003795_abnormal_bone_structure0.95913007
56MP0000049_abnormal_middle_ear0.95831573
57MP0008004_abnormal_stomach_pH0.94024610
58MP0005171_absent_coat_pigmentation0.92822831
59MP0005076_abnormal_cell_differentiation0.92401651
60MP0001661_extended_life_span0.91831215
61MP0003950_abnormal_plasma_membrane0.90612466
62MP0003935_abnormal_craniofacial_develop0.90567094
63MP0003283_abnormal_digestive_organ0.89603935
64MP0002116_abnormal_craniofacial_bone0.89484192
65MP0000751_myopathy0.89033485
66MP0000762_abnormal_tongue_morphology0.88944691
67MP0003937_abnormal_limbs/digits/tail_de0.88862055
68MP0002168_other_aberrant_phenotype0.88107296
69MP0005595_abnormal_vascular_smooth0.87562663
70MP0002128_abnormal_blood_circulation0.85216706
71MP0009780_abnormal_chondrocyte_physiolo0.85017285
72MP0002111_abnormal_tail_morphology0.83648284
73MP0002233_abnormal_nose_morphology0.83212954
74MP0000749_muscle_degeneration0.82701136
75MP0004084_abnormal_cardiac_muscle0.82489086
76MP0003045_fibrosis0.82230980
77MP0005367_renal/urinary_system_phenotyp0.79198102
78MP0000516_abnormal_urinary_system0.79198102
79MP0004233_abnormal_muscle_weight0.78996697
80MP0010386_abnormal_urinary_bladder0.78085445
81MP0001614_abnormal_blood_vessel0.77368988
82MP0002254_reproductive_system_inflammat0.77065106
83MP0000537_abnormal_urethra_morphology0.75310388
84MP0003300_gastrointestinal_ulcer0.75171825
85MP0000003_abnormal_adipose_tissue0.73764265
86MP0005197_abnormal_uvea_morphology0.73551232
87MP0002114_abnormal_axial_skeleton0.73488902
88MP0002177_abnormal_outer_ear0.73124803
89MP0001879_abnormal_lymphatic_vessel0.72677416
90MP0000759_abnormal_skeletal_muscle0.72510615
91MP0005248_abnormal_Harderian_gland0.70600670
92MP0001915_intracranial_hemorrhage0.70280958
93MP0001175_abnormal_lung_morphology0.68171002
94MP0004087_abnormal_muscle_fiber0.67948142
95MP0005193_abnormal_anterior_eye0.67693321
96MP0004185_abnormal_adipocyte_glucose0.65709937
97MP0000462_abnormal_digestive_system0.64543489
98MP0001177_atelectasis0.64460297
99MP0002925_abnormal_cardiovascular_devel0.64206343
100MP0005084_abnormal_gallbladder_morpholo0.63598547
101MP0000858_altered_metastatic_potential0.62049680
102MP0005409_darkened_coat_color0.61482598
103MP0008007_abnormal_cellular_replicative0.60913015
104MP0002249_abnormal_larynx_morphology0.60061512
105MP0004883_abnormal_blood_vessel0.59386423
106MP0005388_respiratory_system_phenotype0.59173698
107MP0002133_abnormal_respiratory_system0.59173698
108MP0003448_altered_tumor_morphology0.57753740
109MP0005165_increased_susceptibility_to0.57162642
110MP0000604_amyloidosis0.57074085
111MP0006138_congestive_heart_failure0.56313121
112MP0005164_abnormal_response_to0.55916874
113MP0010771_integument_phenotype0.51173632
114MP0000343_altered_response_to0.50192535
115MP0005369_muscle_phenotype0.49620104
116MP0003329_amyloid_beta_deposits0.48644955
117MP0001849_ear_inflammation0.45819568
118MP0000538_abnormal_urinary_bladder0.43512430

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)9.04768780
2Protrusio acetabuli (HP:0003179)8.77105048
3Aortic dissection (HP:0002647)5.18609731
4Peritonitis (HP:0002586)4.91452176
5Soft skin (HP:0000977)4.78811903
6Atrophic scars (HP:0001075)4.72078543
7Abnormality of dentin (HP:0010299)4.44760004
8Neonatal short-limb short stature (HP:0008921)4.28891028
9Shallow orbits (HP:0000586)4.19038100
10Biconcave vertebral bodies (HP:0004586)4.04263337
11Fragile skin (HP:0001030)3.95751949
12Dilatation of the ascending aorta (HP:0005111)3.95568099
13Aortic aneurysm (HP:0004942)3.94561878
14Vertebral compression fractures (HP:0002953)3.88474317
15Ankle contracture (HP:0006466)3.88412346
16Genu recurvatum (HP:0002816)3.87631321
17Cerebral aneurysm (HP:0004944)3.78732808
18Cervical subluxation (HP:0003308)3.70330711
19Wormian bones (HP:0002645)3.66440907
20Bladder diverticulum (HP:0000015)3.64236980
21Blue sclerae (HP:0000592)3.50056909
22Mitral valve prolapse (HP:0001634)3.43039330
23Abnormal delivery (HP:0001787)3.06978794
24Spinal rigidity (HP:0003306)3.04171591
25Broad metatarsal (HP:0001783)2.87458961
26Abnormality of the acetabulum (HP:0003170)2.81388464
27Infantile muscular hypotonia (HP:0008947)2.79309985
28Type 1 muscle fiber predominance (HP:0003803)2.72175015
29Follicular hyperkeratosis (HP:0007502)2.69957247
30Hyperextensible skin (HP:0000974)2.69231684
31Short nail (HP:0001799)2.66396753
32Wrist flexion contracture (HP:0001239)2.65665243
33Increased connective tissue (HP:0009025)2.64793722
34Overgrowth (HP:0001548)2.60004578
35Osteoarthritis (HP:0002758)2.57927477
36Bowel diverticulosis (HP:0005222)2.57841805
37Mesomelia (HP:0003027)2.52545718
38Mild short stature (HP:0003502)2.51985774
39Wide anterior fontanel (HP:0000260)2.50139789
40Coxa vara (HP:0002812)2.48981315
41Vascular tortuosity (HP:0004948)2.47806771
42Hypoventilation (HP:0002791)2.46714234
43Osteolytic defects of the hand bones (HP:0009699)2.46333717
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.46333717
45Cupped ribs (HP:0000887)2.45895531
46Breech presentation (HP:0001623)2.44302457
47Hypoplastic ischia (HP:0003175)2.39369491
48Elbow flexion contracture (HP:0002987)2.38781643
49Mildly elevated creatine phosphokinase (HP:0008180)2.35000241
50Ectopia lentis (HP:0001083)2.33761006
51Striae distensae (HP:0001065)2.31547106
52Mitral regurgitation (HP:0001653)2.29709624
53Decreased skull ossification (HP:0004331)2.29646492
54Increased density of long bones (HP:0006392)2.29246039
55Epiphyseal dysplasia (HP:0002656)2.28935675
56Tibial bowing (HP:0002982)2.28686667
57Abnormality of skeletal muscle fiber size (HP:0012084)2.28138965
58Spinal cord lesions (HP:0100561)2.24575748
59Syringomyelia (HP:0003396)2.24575748
60Increased corneal curvature (HP:0100692)2.22902210
61Keratoconus (HP:0000563)2.22902210
62Mitral stenosis (HP:0001718)2.21176058
63Abnormality of the peritoneum (HP:0002585)2.18775316
64Aortic valve stenosis (HP:0001650)2.18696012
65Deviation of the hallux (HP:0010051)2.18542576
66Joint laxity (HP:0001388)2.18499934
67Abnormality of the calcaneus (HP:0008364)2.17463408
68Hallux valgus (HP:0001822)2.15064161
69Platyspondyly (HP:0000926)2.13302022
70Bell-shaped thorax (HP:0001591)2.11875397
71Camptodactyly of toe (HP:0001836)2.08797397
72Abnormality of skull ossification (HP:0002703)2.08615702
73Delayed closure of the anterior fontanelle (HP:0001476)2.07531670
74Nonimmune hydrops fetalis (HP:0001790)2.06872031
75Slender build (HP:0001533)2.06861262
76Aneurysm (HP:0002617)2.06720192
77Broad long bones (HP:0005622)2.04767115
78Abnormality of the ischium (HP:0003174)2.04757939
79Redundant skin (HP:0001582)2.04350553
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04316208
81Arterial tortuosity (HP:0005116)2.04114257
82Spinal cord compression (HP:0002176)2.03874879
83Generalized amyotrophy (HP:0003700)2.03701368
84Femoral bowing (HP:0002980)2.03582140
85Delayed cranial suture closure (HP:0000270)2.01213801
86Ulnar bowing (HP:0003031)2.00570489
87Venous insufficiency (HP:0005293)2.00302496
88Beaking of vertebral bodies (HP:0004568)1.99946026
89Distal lower limb amyotrophy (HP:0008944)1.99920792
90Protruding ear (HP:0000411)1.99868238
91Alopecia of scalp (HP:0002293)1.99073411
92Radial bowing (HP:0002986)1.98067962
93Premature skin wrinkling (HP:0100678)1.96798321
94Broad ribs (HP:0000885)1.95579850
95Knee flexion contracture (HP:0006380)1.95011482
96Morphological abnormality of the middle ear (HP:0008609)1.94436893
97Thin bony cortex (HP:0002753)1.93651328
98Round ear (HP:0100830)1.93642770
99Coronal craniosynostosis (HP:0004440)1.93312656
100Vitreoretinal degeneration (HP:0000655)1.93135652
101Narrow nasal bridge (HP:0000446)1.91987964
102Spondylolisthesis (HP:0003302)1.91790302
103Renovascular hypertension (HP:0100817)1.91016089
104Difficulty climbing stairs (HP:0003551)1.90726967
105Hypoplasia of the iris (HP:0007676)1.90334510
106Ovoid vertebral bodies (HP:0003300)1.90125668
107Scapular winging (HP:0003691)1.87617202
108Gingival overgrowth (HP:0000212)1.85159531
109Increased variability in muscle fiber diameter (HP:0003557)1.84947209
110Venous abnormality (HP:0002624)1.84221014
111Absent frontal sinuses (HP:0002688)1.84018785
112Metaphyseal dysplasia (HP:0100255)1.83634668
113Abnormality of the distal phalanges of the toes (HP:0010182)1.80884361
114Hip contracture (HP:0003273)1.80120623
115Buphthalmos (HP:0000557)1.79883771
116Pulmonary artery stenosis (HP:0004415)1.79467188
117Osteopenia (HP:0000938)1.79051343
118Disproportionate tall stature (HP:0001519)1.78899736
119Thoracolumbar scoliosis (HP:0002944)1.78167993
120Thin skin (HP:0000963)1.75033077
121Calcaneovalgus deformity (HP:0001848)1.74614210
122Joint stiffness (HP:0001387)1.73650001
123Inguinal hernia (HP:0000023)1.72227893
124Renal duplication (HP:0000075)1.71761605
125Aortic regurgitation (HP:0001659)1.70874411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.79450295
2TTN4.05352069
3TRIB33.45317142
4PDGFRA3.15593381
5LATS23.12059270
6LATS12.92452980
7PKN22.34411660
8TESK12.31690138
9PIM22.30237658
10LIMK12.28234015
11FER2.27818569
12TRPM72.27241183
13PAK22.23978287
14AKT32.05124793
15KIT1.98133159
16EPHB21.94601044
17PIK3CA1.70108508
18PAK31.68710267
19PRPF4B1.65270455
20PTK21.63689792
21RPS6KA41.60836052
22MOS1.59506951
23DMPK1.58152784
24PAK41.55509137
25NEK91.54484907
26EPHA31.54062646
27STK381.49948699
28JAK11.49256556
29TESK21.47916539
30ERBB31.45793780
31PTK2B1.45602220
32MAP3K61.40123550
33NME21.39161988
34BMX1.38459571
35STK38L1.37666230
36STK31.35728181
37ERN11.35372489
38RIPK11.32441358
39SIK11.32111222
40FGFR41.30951502
41MAPK71.29101996
42EPHA21.26771770
43PDK21.21992258
44PIK3CG1.19455780
45MYLK1.18063198
46ROCK11.16364441
47NLK1.15890417
48FRK1.15237714
49LRRK21.13002507
50FGFR11.08852705
51CLK11.08690517
52ILK1.08317830
53MET1.07132025
54PDGFRB1.04265961
55PTK60.99432118
56MAP3K30.98510375
57PLK20.97132456
58EIF2AK10.96638090
59TYK20.95895649
60JAK30.93069169
61MAP3K130.90638589
62DAPK30.89252051
63PRKG20.84346879
64GSK3A0.84220129
65MTOR0.83469393
66NUAK10.83466014
67CDK60.81656928
68ARAF0.80011351
69DYRK1B0.79834322
70TGFBR20.78987637
71STK240.73549837
72ZAK0.71767336
73ICK0.69429132
74CDK140.68490609
75FLT30.68135339
76INSR0.67822753
77ROCK20.67819749
78PRKD30.66527413
79KSR20.64715395
80PAK10.64694320
81TGFBR10.62363455
82MAP2K10.61793883
83TIE10.59387734
84MKNK10.58391588
85PRKD20.57467251
86FGFR30.57010540
87ABL20.56848193
88SCYL20.56705610
89GRK50.56431039
90ADRBK10.56314026
91PRKCE0.54565459
92CDC42BPA0.54239147
93CDK150.53206542
94STK100.50674358
95CDK80.50047768
96CDK180.48790607
97MAP3K80.48697508
98RPS6KA20.47584901
99PRKD10.46693750
100GRK10.46110613
101RET0.45122799
102CDK11A0.44802886
103PAK60.43601825
104NTRK10.43294963
105MAPKAPK30.42186628
106TAOK20.38967016
107IRAK30.38540668
108MAPK40.37170771
109MAP3K100.37024745
110WNK10.36104793
111PDPK10.35690402
112SRC0.35393722
113ERBB40.35363139
114MAP3K70.33780488
115GRK70.31747029
116MAPK120.31621167
117MELK0.31587816
118PBK0.31537292
119EEF2K0.31167791
120LMTK20.29806487
121TAOK10.29147111
122MAP3K10.27038296
123CAMK1G0.26883727
124EPHB10.26645224
125CAMKK20.26511376
126MST1R0.25833785
127NEK60.25734510
128MAPK10.25435765
129ABL10.24502538
130PLK30.24182273
131IGF1R0.23984457
132CDK90.23643775
133PRKCH0.23543587
134MAPKAPK20.23329728
135ERBB20.22531206
136MAP3K50.22438221
137CAMKK10.19964666
138CSK0.19227207

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.88846429
2Focal adhesion_Homo sapiens_hsa045103.43057609
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.24388077
4Protein digestion and absorption_Homo sapiens_hsa049742.69803075
5Proteoglycans in cancer_Homo sapiens_hsa052052.56333812
6Bladder cancer_Homo sapiens_hsa052192.44083532
7TGF-beta signaling pathway_Homo sapiens_hsa043502.41142100
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.37159227
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28112990
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.21669421
11Dilated cardiomyopathy_Homo sapiens_hsa054142.21587037
12Malaria_Homo sapiens_hsa051442.18072372
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.17966771
14Hippo signaling pathway_Homo sapiens_hsa043902.13770640
15Adherens junction_Homo sapiens_hsa045202.10960772
16Amoebiasis_Homo sapiens_hsa051462.07871540
17MicroRNAs in cancer_Homo sapiens_hsa052061.99270234
18Small cell lung cancer_Homo sapiens_hsa052221.87984075
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.87336928
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.82604161
21p53 signaling pathway_Homo sapiens_hsa041151.75382522
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.74473101
23Complement and coagulation cascades_Homo sapiens_hsa046101.72628542
24Melanoma_Homo sapiens_hsa052181.64165493
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61265707
26Chronic myeloid leukemia_Homo sapiens_hsa052201.54247226
27Basal cell carcinoma_Homo sapiens_hsa052171.53721867
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.53510104
29Shigellosis_Homo sapiens_hsa051311.51983819
30Hedgehog signaling pathway_Homo sapiens_hsa043401.36373340
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36282789
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.35735847
33Prostate cancer_Homo sapiens_hsa052151.24770475
34Tight junction_Homo sapiens_hsa045301.22192803
35Viral myocarditis_Homo sapiens_hsa054161.20720215
36Other glycan degradation_Homo sapiens_hsa005111.20609585
37Glioma_Homo sapiens_hsa052141.20443460
38HTLV-I infection_Homo sapiens_hsa051661.12783115
39Platelet activation_Homo sapiens_hsa046111.10798888
40Wnt signaling pathway_Homo sapiens_hsa043101.08170191
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07792075
42Rap1 signaling pathway_Homo sapiens_hsa040151.06503522
43Prion diseases_Homo sapiens_hsa050201.04344636
44Pancreatic cancer_Homo sapiens_hsa052121.04151565
45Pathways in cancer_Homo sapiens_hsa052001.03565228
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03169475
47Sulfur metabolism_Homo sapiens_hsa009201.02223948
48Mineral absorption_Homo sapiens_hsa049781.01950085
49Axon guidance_Homo sapiens_hsa043600.99239166
50TNF signaling pathway_Homo sapiens_hsa046680.98128305
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97593631
52HIF-1 signaling pathway_Homo sapiens_hsa040660.92137690
53Phagosome_Homo sapiens_hsa041450.90339863
54Pertussis_Homo sapiens_hsa051330.86739178
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.86170163
56Phototransduction_Homo sapiens_hsa047440.85732806
57Hepatitis B_Homo sapiens_hsa051610.81191699
58One carbon pool by folate_Homo sapiens_hsa006700.80414478
59Renal cell carcinoma_Homo sapiens_hsa052110.77636345
60Viral carcinogenesis_Homo sapiens_hsa052030.77293076
61Protein export_Homo sapiens_hsa030600.74604989
62Salmonella infection_Homo sapiens_hsa051320.73890158
63Melanogenesis_Homo sapiens_hsa049160.73342172
64Apoptosis_Homo sapiens_hsa042100.73121233
65Cell cycle_Homo sapiens_hsa041100.72642679
66Toxoplasmosis_Homo sapiens_hsa051450.72058260
67Gap junction_Homo sapiens_hsa045400.71220810
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67643035
69Lysosome_Homo sapiens_hsa041420.65887814
70Choline metabolism in cancer_Homo sapiens_hsa052310.65660587
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63604195
72Colorectal cancer_Homo sapiens_hsa052100.60002882
73Ras signaling pathway_Homo sapiens_hsa040140.59777546
74N-Glycan biosynthesis_Homo sapiens_hsa005100.58045403
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57566952
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56973733
77Dorso-ventral axis formation_Homo sapiens_hsa043200.56295830
78Staphylococcus aureus infection_Homo sapiens_hsa051500.56269617
79Endocytosis_Homo sapiens_hsa041440.53926719
80Thyroid hormone synthesis_Homo sapiens_hsa049180.52379073
81Thyroid cancer_Homo sapiens_hsa052160.52182961
82Ovarian steroidogenesis_Homo sapiens_hsa049130.51404685
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50711761
84FoxO signaling pathway_Homo sapiens_hsa040680.50572592
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49582676
86ErbB signaling pathway_Homo sapiens_hsa040120.49038009
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.46537762
88Endometrial cancer_Homo sapiens_hsa052130.46412425
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45859080
90Circadian rhythm_Homo sapiens_hsa047100.44595545
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.43777919
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43694386
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43638669
94Renin secretion_Homo sapiens_hsa049240.43605118
95Insulin resistance_Homo sapiens_hsa049310.42882329
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42851639
97VEGF signaling pathway_Homo sapiens_hsa043700.42659556
98Estrogen signaling pathway_Homo sapiens_hsa049150.42021005
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.40812314
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40729123
101Prolactin signaling pathway_Homo sapiens_hsa049170.40373336
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40140566
103mTOR signaling pathway_Homo sapiens_hsa041500.39828672
104GnRH signaling pathway_Homo sapiens_hsa049120.37637706
105MAPK signaling pathway_Homo sapiens_hsa040100.37487699
106Leishmaniasis_Homo sapiens_hsa051400.37050600
107Cocaine addiction_Homo sapiens_hsa050300.36751986
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.36615684
109Galactose metabolism_Homo sapiens_hsa000520.36416233
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.35262335
111ABC transporters_Homo sapiens_hsa020100.35142125
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34989610
113Hepatitis C_Homo sapiens_hsa051600.32468447
114Vibrio cholerae infection_Homo sapiens_hsa051100.31912726
115Lysine degradation_Homo sapiens_hsa003100.30778467
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27499387
117AMPK signaling pathway_Homo sapiens_hsa041520.25851216
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25294748
119Non-small cell lung cancer_Homo sapiens_hsa052230.24426031
120Acute myeloid leukemia_Homo sapiens_hsa052210.23377230
121Osteoclast differentiation_Homo sapiens_hsa043800.23316718
122RNA transport_Homo sapiens_hsa030130.23185119
123Notch signaling pathway_Homo sapiens_hsa043300.21405650
124Renin-angiotensin system_Homo sapiens_hsa046140.20170215
125Insulin signaling pathway_Homo sapiens_hsa049100.19702670

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