WISP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.67670317
2collagen fibril organization (GO:0030199)7.43531207
3extracellular matrix assembly (GO:0085029)6.37895159
4sequestering of extracellular ligand from receptor (GO:0035581)6.32234075
5bone trabecula formation (GO:0060346)5.54515604
6regulation of tight junction assembly (GO:2000810)5.50116855
7extracellular fibril organization (GO:0043206)5.36312826
8peptidyl-proline hydroxylation (GO:0019511)5.34687198
9fibril organization (GO:0097435)5.30470607
10dermatan sulfate biosynthetic process (GO:0030208)5.21985098
11chondrocyte proliferation (GO:0035988)5.07582438
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.06189797
13skin morphogenesis (GO:0043589)5.02656620
14cell adhesion mediated by integrin (GO:0033627)4.89713709
15triglyceride catabolic process (GO:0019433)4.83823653
16dermatan sulfate metabolic process (GO:0030205)4.80789536
17low-density lipoprotein particle clearance (GO:0034383)4.78230124
18wound healing, spreading of epidermal cells (GO:0035313)4.71695354
19endodermal cell differentiation (GO:0035987)4.66953749
20virion attachment to host cell (GO:0019062)4.65611622
21adhesion of symbiont to host cell (GO:0044650)4.65611622
22positive regulation of endothelial cell apoptotic process (GO:2000353)4.62244131
23cellular response to vitamin (GO:0071295)4.58226670
24collagen metabolic process (GO:0032963)4.47562863
25regulation of sequestering of triglyceride (GO:0010889)4.39899395
26epoxygenase P450 pathway (GO:0019373)4.37706937
27protein hydroxylation (GO:0018126)4.34530478
28protein localization to cell surface (GO:0034394)4.32547857
29collagen catabolic process (GO:0030574)4.31461528
30negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.30223484
31cell migration involved in heart development (GO:0060973)4.27829445
32negative regulation of chondrocyte differentiation (GO:0032331)4.24263425
33positive regulation of fatty acid oxidation (GO:0046321)4.18825002
34acylglycerol catabolic process (GO:0046464)4.17457627
35neutral lipid catabolic process (GO:0046461)4.17457627
36multicellular organismal macromolecule metabolic process (GO:0044259)4.16754749
37regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.15898659
38glomerular basement membrane development (GO:0032836)4.15348467
39retina vasculature morphogenesis in camera-type eye (GO:0061299)4.12663793
40mesenchymal-epithelial cell signaling (GO:0060638)4.11827848
41glomerular filtration (GO:0003094)4.11478417
42apoptotic cell clearance (GO:0043277)4.07333950
43regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.04325527
44cellular response to interferon-alpha (GO:0035457)3.98690367
45multicellular organismal metabolic process (GO:0044236)3.94709853
46multicellular organismal catabolic process (GO:0044243)3.93918162
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.93193935
48axon extension involved in axon guidance (GO:0048846)3.93193935
49wound healing, spreading of cells (GO:0044319)3.90846902
50omega-hydroxylase P450 pathway (GO:0097267)3.89978208
51adhesion of symbiont to host (GO:0044406)3.84658800
52peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.82256892
53COPI coating of Golgi vesicle (GO:0048205)3.82204791
54Golgi transport vesicle coating (GO:0048200)3.82204791
55protein retention in ER lumen (GO:0006621)3.78469021
56extracellular matrix disassembly (GO:0022617)3.77462898
57protein targeting to plasma membrane (GO:0072661)3.77423735
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.75070407
59regulation of vitamin D biosynthetic process (GO:0060556)3.69696258
60type B pancreatic cell proliferation (GO:0044342)3.69464646
61negative regulation of complement activation (GO:0045916)3.67493172
62metanephric mesenchyme development (GO:0072075)3.63047059
63regulation of integrin-mediated signaling pathway (GO:2001044)3.62880186
64positive regulation of fatty acid beta-oxidation (GO:0032000)3.61453039
65positive regulation of vascular permeability (GO:0043117)3.60351271
66UV protection (GO:0009650)3.59729000
67renal filtration (GO:0097205)3.57739687
68induction of positive chemotaxis (GO:0050930)3.56610352
69keratan sulfate catabolic process (GO:0042340)3.55921925
70cartilage morphogenesis (GO:0060536)3.55740605
71extracellular matrix organization (GO:0030198)3.55307145
72cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.54000541
73extracellular structure organization (GO:0043062)3.53791282
74positive regulation of glomerulus development (GO:0090193)3.53225165
75cellular response to vitamin D (GO:0071305)3.51573219
76epithelial cell-cell adhesion (GO:0090136)3.50333738
77negative regulation of catenin import into nucleus (GO:0035414)3.48307032
78craniofacial suture morphogenesis (GO:0097094)3.42079298
79regulation of triglyceride biosynthetic process (GO:0010866)3.41872225
80negative regulation of granulocyte differentiation (GO:0030853)3.39580966
81positive regulation of extracellular matrix organization (GO:1903055)3.39166769
82positive regulation of natural killer cell differentiation (GO:0032825)3.37558104
83negative regulation of cartilage development (GO:0061037)3.37334119
84kidney mesenchyme development (GO:0072074)3.36167550
85endocrine hormone secretion (GO:0060986)3.34419593
86chondroitin sulfate biosynthetic process (GO:0030206)3.34376348
87negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.29590088
88negative regulation of fatty acid transport (GO:2000192)3.28933763
89endothelial cell morphogenesis (GO:0001886)3.28411131
90negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.26986693
91regulation of vitamin metabolic process (GO:0030656)3.23030240
92protein trimerization (GO:0070206)3.21949874
93regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.13596971
94positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11527632
95extracellular regulation of signal transduction (GO:1900115)3.11486126
96extracellular negative regulation of signal transduction (GO:1900116)3.11486126
97positive regulation of metanephros development (GO:0072216)3.11322698
98positive regulation of blood vessel endothelial cell migration (GO:0043536)3.10817899
99substrate-dependent cell migration (GO:0006929)3.09023265
100regulation of plasminogen activation (GO:0010755)3.06357849
101negative regulation of protein activation cascade (GO:2000258)3.05681824
102negative regulation of embryonic development (GO:0045992)3.01267650
103cranial suture morphogenesis (GO:0060363)3.00956763
104glycerolipid catabolic process (GO:0046503)3.00709871
105sulfur compound catabolic process (GO:0044273)3.00217493
106blood vessel maturation (GO:0001955)2.99625128
107cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98877386
108smooth muscle tissue development (GO:0048745)2.97907645
109negative regulation of macrophage differentiation (GO:0045650)2.97161226
110basement membrane organization (GO:0071711)2.97150145
111endothelial cell proliferation (GO:0001935)2.96746120
112negative regulation of fibroblast apoptotic process (GO:2000270)2.96641096
113vascular endothelial growth factor signaling pathway (GO:0038084)2.95987211
114positive regulation of digestive system process (GO:0060456)2.94283324
115regulation of fatty acid oxidation (GO:0046320)2.93824215
116cellular response to amino acid stimulus (GO:0071230)2.92759906
117interleukin-6-mediated signaling pathway (GO:0070102)2.92445036
118platelet degranulation (GO:0002576)2.92251910
119cellular response to epinephrine stimulus (GO:0071872)2.91826301
120cellular response to nutrient (GO:0031670)2.91400091
121endocardial cushion development (GO:0003197)2.90865848
122positive regulation of odontogenesis (GO:0042482)2.90525913
123negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89705410
124response to food (GO:0032094)2.88838831
125response to fluid shear stress (GO:0034405)2.88251094
126prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.87574838
127response to dietary excess (GO:0002021)2.87534102
128opsonization (GO:0008228)2.87276462
129short-term memory (GO:0007614)2.87249388
130regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.86863836
131keratan sulfate metabolic process (GO:0042339)2.85690215
132tooth mineralization (GO:0034505)2.84399625
133protein carboxylation (GO:0018214)2.83831474
134peptidyl-glutamic acid carboxylation (GO:0017187)2.83831474
135branching involved in prostate gland morphogenesis (GO:0060442)2.83614170
136white fat cell differentiation (GO:0050872)2.83236704
137middle ear morphogenesis (GO:0042474)2.83224141
138negative regulation of smooth muscle cell proliferation (GO:0048662)2.83070873
139regulation of uterine smooth muscle contraction (GO:0070472)2.81749990
140norepinephrine metabolic process (GO:0042415)2.79783178
141brown fat cell differentiation (GO:0050873)2.79052011
142muscle cell migration (GO:0014812)2.75421048
143cardiac epithelial to mesenchymal transition (GO:0060317)2.74315714
144phagocytosis, recognition (GO:0006910)2.70434817
145negative regulation of gluconeogenesis (GO:0045721)2.69100432
146positive regulation of triglyceride biosynthetic process (GO:0010867)2.68788903
147keratan sulfate biosynthetic process (GO:0018146)2.68598849
148positive regulation of fatty acid metabolic process (GO:0045923)2.61940698
149regulation of fatty acid beta-oxidation (GO:0031998)2.60879362
150cGMP-mediated signaling (GO:0019934)2.60828959
151negative regulation of smooth muscle cell migration (GO:0014912)2.60801595
152ovulation from ovarian follicle (GO:0001542)2.60759999
153polyol transport (GO:0015791)2.58353692
154regulation of glycogen (starch) synthase activity (GO:2000465)2.57510915
155response to nitrosative stress (GO:0051409)2.56672115
156positive regulation of glycogen metabolic process (GO:0070875)2.55488623
157cornea development in camera-type eye (GO:0061303)2.54761505
158response to epinephrine (GO:0071871)2.53736508
159adrenergic receptor signaling pathway (GO:0071875)2.52952827
160negative regulation of BMP signaling pathway (GO:0030514)2.52356412
161atrioventricular valve morphogenesis (GO:0003181)2.51671125
162cell proliferation involved in metanephros development (GO:0072203)2.50407783
163positive regulation of glycogen biosynthetic process (GO:0045725)2.48570540
164biotin metabolic process (GO:0006768)2.46148822
165response to dexamethasone (GO:0071548)2.46139295
166tachykinin receptor signaling pathway (GO:0007217)2.45856024
167cAMP catabolic process (GO:0006198)2.45410459
168lipid particle organization (GO:0034389)2.43933495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.37806969
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.81027243
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse5.45287163
4TP63_17297297_ChIP-ChIP_HaCaT_Human5.23399233
5CLOCK_20551151_ChIP-Seq_293T_Human4.00142134
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.40804772
7* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.40497972
8CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse3.17295432
9CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.92729816
10* CJUN_26792858_Chip-Seq_BT549_Human2.92531770
11ZNF263_19887448_ChIP-Seq_K562_Human2.82767734
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.79462463
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.57268647
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.39587512
15NRF2_20460467_ChIP-Seq_MEFs_Mouse2.39587512
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34139611
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23943978
18BRD4_25478319_ChIP-Seq_HGPS_Human2.15062461
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.05840549
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05682641
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.94376046
22AHR_22903824_ChIP-Seq_MCF-7_Human1.92825452
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89233757
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85244514
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.85146333
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84994717
27* ESR1_21235772_ChIP-Seq_MCF-7_Human1.81820155
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81364339
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80966068
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78894403
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77903950
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.75776681
33* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.73715079
34* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.73701445
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73206344
36* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71512989
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.62419928
38* SMC4_20622854_ChIP-Seq_HELA_Human1.57588830
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.56397015
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54346969
41* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52922006
42P68_20966046_ChIP-Seq_HELA_Human1.50137352
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48793940
44TP53_18474530_ChIP-ChIP_U2OS_Human1.47347022
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.47074241
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45610955
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45486471
48SOX2_20726797_ChIP-Seq_SW620_Human1.45121873
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44764304
50* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44307051
51* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.44087206
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42620529
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41069965
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39571623
55TP53_23651856_ChIP-Seq_MEFs_Mouse1.37340454
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37305657
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37305657
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37120602
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37120602
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.37007678
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.35953509
62CTCF_27219007_Chip-Seq_Bcells_Human1.35527890
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34741909
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33621323
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.33238918
66* RUNX1_27514584_Chip-Seq_MCF-7_Human1.32589004
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32250801
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.30904312
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30654732
70* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30475184
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.28699494
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28669537
73RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27941706
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27293022
75* ESR2_21235772_ChIP-Seq_MCF-7_Human1.26467807
76* CTCF_26484167_Chip-Seq_Bcells_Mouse1.26174487
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25999017
78ATF3_27146783_Chip-Seq_COLON_Human1.24786436
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24637177
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24494136
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.23811898
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.23735642
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23526914
84TP53_22127205_ChIP-Seq_IMR90_Human1.23163689
85TP53_16413492_ChIP-PET_HCT116_Human1.22950501
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.21925651
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.21800846
88STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.21759499
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21574188
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21558000
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20018509
92* ERA_21632823_ChIP-Seq_H3396_Human1.19441371
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19017225
94* SA1_22415368_ChIP-Seq_MEFs_Mouse1.18688049
95* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17890353
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17415981
97* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17177260
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17101086
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16167181
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15635714
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11552472
102E2F1_20622854_ChIP-Seq_HELA_Human1.10816458
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10339519
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10020334
105* GATA3_24758297_ChIP-Seq_MCF-7_Human1.09985750
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08638878
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08411620
108DROSHA_22980978_ChIP-Seq_HELA_Human1.08384086
109CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07022644
110* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06794420
111* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06794420
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06772507
113RAC3_21632823_ChIP-Seq_H3396_Human1.06673345
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06669084
115* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05580746
116* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01405036
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.00845854
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99831685
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99564762
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99312919
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.99203588
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98616767
123* RARB_24833708_ChIP-Seq_LIVER_Mouse0.98311759
124SA1_27219007_Chip-Seq_Bcells_Human0.98065966
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96132137
126* NFI_21473784_ChIP-Seq_ESCs_Mouse0.95984240
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95673102
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94651827
129RACK7_27058665_Chip-Seq_MCF-7_Human0.94532198
130JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92382008
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91221326
132TP63_22573176_ChIP-Seq_HFKS_Human0.91216189
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90281657
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90265522
135ELF1_20517297_ChIP-Seq_JURKAT_Human0.89459670
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89188515
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88703332
138BCL6_27268052_Chip-Seq_Bcells_Human0.88570367
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.86519561
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85490129
141EOMES_21245162_ChIP-Seq_HESCs_Human0.84130017
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83514057
143* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83369452
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82375280
145LXR_22292898_ChIP-Seq_THP-1_Human0.81603141
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80533272
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80317333
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79077920
149GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78726624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.31250216
2MP0003705_abnormal_hypodermis_morpholog5.81668028
3MP0005275_abnormal_skin_tensile5.74368832
4MP0005503_abnormal_tendon_morphology5.67109720
5MP0003279_aneurysm5.41521005
6MP0001958_emphysema5.21475093
7MP0009384_cardiac_valve_regurgitation4.20869640
8MP0005670_abnormal_white_adipose4.09232339
9MP0002295_abnormal_pulmonary_circulatio2.71218044
10MP0006054_spinal_hemorrhage2.69007827
11MP0004130_abnormal_muscle_cell2.40556695
12MP0005375_adipose_tissue_phenotype2.21673579
13MP0005257_abnormal_intraocular_pressure2.14488744
14MP0005508_abnormal_skeleton_morphology2.03372571
15MP0005666_abnormal_adipose_tissue2.01859350
16MP0005023_abnormal_wound_healing1.98352769
17MP0004272_abnormal_basement_membrane1.97817134
18MP0002060_abnormal_skin_morphology1.92620855
19MP0005623_abnormal_meninges_morphology1.86873826
20MP0002971_abnormal_brown_adipose1.80020603
21MP0001542_abnormal_bone_strength1.75799261
22MP0003566_abnormal_cell_adhesion1.68547565
23MP0001661_extended_life_span1.63392740
24MP0002108_abnormal_muscle_morphology1.58552925
25MP0003646_muscle_fatigue1.56392174
26MP0002933_joint_inflammation1.55867622
27MP0003724_increased_susceptibility_to1.54364420
28MP0009780_abnormal_chondrocyte_physiolo1.51659531
29MP0003091_abnormal_cell_migration1.50032087
30MP0006138_congestive_heart_failure1.47923868
31MP0000767_abnormal_smooth_muscle1.46906440
32MP0001243_abnormal_dermal_layer1.44795688
33MP0003186_abnormal_redox_activity1.42193813
34MP0010368_abnormal_lymphatic_system1.39294393
35MP0000013_abnormal_adipose_tissue1.38548202
36MP0002970_abnormal_white_adipose1.32364705
37MP0005390_skeleton_phenotype1.32176436
38MP0009115_abnormal_fat_cell1.31346534
39MP0010352_gastrointestinal_tract_polyps1.30767791
40MP0005595_abnormal_vascular_smooth1.30453199
41MP0002876_abnormal_thyroid_physiology1.29820157
42MP0003959_abnormal_lean_body1.29541200
43MP0010030_abnormal_orbit_morphology1.27593752
44MP0003385_abnormal_body_wall1.21306443
45MP0009250_abnormal_appendicular_skeleto1.20000672
46MP0004134_abnormal_chest_morphology1.19270657
47MP0004883_abnormal_blood_vessel1.16735413
48MP0004185_abnormal_adipocyte_glucose1.15306700
49MP0005171_absent_coat_pigmentation1.14774429
50MP0003011_delayed_dark_adaptation1.12266048
51MP0004381_abnormal_hair_follicle1.12257437
52MP0002896_abnormal_bone_mineralization1.12022107
53MP0001879_abnormal_lymphatic_vessel1.11964483
54MP0005083_abnormal_biliary_tract1.11331038
55MP0002133_abnormal_respiratory_system1.06431735
56MP0005388_respiratory_system_phenotype1.06431735
57MP0002282_abnormal_trachea_morphology1.05359162
58MP0005334_abnormal_fat_pad1.05283268
59MP0001533_abnormal_skeleton_physiology1.05078649
60MP0001299_abnormal_eye_distance/1.00705138
61MP0005164_abnormal_response_to0.99853691
62MP0000163_abnormal_cartilage_morphology0.95060035
63MP0000538_abnormal_urinary_bladder0.94656527
64MP0003136_yellow_coat_color0.91909796
65MP0002638_abnormal_pupillary_reflex0.91434560
66MP0000230_abnormal_systemic_arterial0.90613295
67MP0000858_altered_metastatic_potential0.90189811
68MP0000751_myopathy0.89711522
69MP0003950_abnormal_plasma_membrane0.88412111
70MP0004087_abnormal_muscle_fiber0.87982528
71MP0002168_other_aberrant_phenotype0.87633703
72MP0002115_abnormal_skeleton_extremities0.86581404
73MP0002998_abnormal_bone_remodeling0.85683426
74MP0010329_abnormal_lipoprotein_level0.85439400
75MP0005058_abnormal_lysosome_morphology0.83382884
76MP0005084_abnormal_gallbladder_morpholo0.82852866
77MP0001177_atelectasis0.82488538
78MP0005385_cardiovascular_system_phenoty0.81623265
79MP0001544_abnormal_cardiovascular_syste0.81623265
80MP0005647_abnormal_sex_gland0.81552767
81MP0002128_abnormal_blood_circulation0.80997104
82MP0002877_abnormal_melanocyte_morpholog0.80920112
83MP0003448_altered_tumor_morphology0.79378691
84MP0000428_abnormal_craniofacial_morphol0.75535181
85MP0002932_abnormal_joint_morphology0.75335578
86MP0005452_abnormal_adipose_tissue0.74605451
87MP0000343_altered_response_to0.74291111
88MP0001348_abnormal_lacrimal_gland0.74280101
89MP0000003_abnormal_adipose_tissue0.74066876
90MP0005551_abnormal_eye_electrophysiolog0.73252169
91MP0000733_abnormal_muscle_development0.72912417
92MP0002113_abnormal_skeleton_development0.72410879
93MP0005174_abnormal_tail_pigmentation0.71581842
94MP0003300_gastrointestinal_ulcer0.70872367
95MP0008775_abnormal_heart_ventricle0.70624860
96MP0002796_impaired_skin_barrier0.70277474
97MP0003115_abnormal_respiratory_system0.70138642
98MP0009278_abnormal_bone_marrow0.69044250
99MP0003137_abnormal_impulse_conducting0.68035271
100MP0003283_abnormal_digestive_organ0.67727914
101MP0003045_fibrosis0.66816324
102MP0003795_abnormal_bone_structure0.66643748
103MP0001614_abnormal_blood_vessel0.66539356
104MP0001175_abnormal_lung_morphology0.66433844
105MP0009643_abnormal_urine_homeostasis0.65418556
106MP0010771_integument_phenotype0.65376400
107MP0000249_abnormal_blood_vessel0.65110650
108MP0005165_increased_susceptibility_to0.64028418
109MP0003942_abnormal_urinary_system0.63734704
110MP0000759_abnormal_skeletal_muscle0.63525218
111MP0002118_abnormal_lipid_homeostasis0.63223786
112MP0001915_intracranial_hemorrhage0.62300889
113MP0001502_abnormal_circadian_rhythm0.61715637
114MP0005167_abnormal_blood-brain_barrier0.61054996
115MP0002837_dystrophic_cardiac_calcinosis0.60688649
116MP0005197_abnormal_uvea_morphology0.59536555
117MP0002909_abnormal_adrenal_gland0.58906869
118MP0010386_abnormal_urinary_bladder0.58391146
119MP0005448_abnormal_energy_balance0.58384349
120MP0005501_abnormal_skin_physiology0.57431611
121MP0000372_irregular_coat_pigmentation0.57067465
122MP0001756_abnormal_urination0.56261870
123MP0000747_muscle_weakness0.55830118
124MP0000749_muscle_degeneration0.54859685
125MP0002269_muscular_atrophy0.54676149
126MP0004084_abnormal_cardiac_muscle0.53980506
127MP0000750_abnormal_muscle_regeneration0.51249991
128MP0005220_abnormal_exocrine_pancreas0.50012862
129MP0004233_abnormal_muscle_weight0.49993210
130MP0000534_abnormal_ureter_morphology0.49486519
131MP0003252_abnormal_bile_duct0.46765266
132MP0002928_abnormal_bile_duct0.46378663
133MP0005193_abnormal_anterior_eye0.45312263
134MP0003755_abnormal_palate_morphology0.45132877
135MP0009053_abnormal_anal_canal0.43006089
136MP0002249_abnormal_larynx_morphology0.42299752
137MP0002109_abnormal_limb_morphology0.40630199
138MP0002925_abnormal_cardiovascular_devel0.40170934
139MP0003195_calcinosis0.39597264
140MP0000049_abnormal_middle_ear0.39242797
141MP0004858_abnormal_nervous_system0.39183679
142MP0005369_muscle_phenotype0.37858749
143MP0004808_abnormal_hematopoietic_stem0.37833287
144MP0002938_white_spotting0.37424428
145MP0005620_abnormal_muscle_contractility0.36900677
146MP0002111_abnormal_tail_morphology0.36087689

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.85018065
2Aortic aneurysm (HP:0004942)7.38639057
3Vascular tortuosity (HP:0004948)6.08071745
4Soft skin (HP:0000977)5.86289834
5Bladder diverticulum (HP:0000015)5.83548924
6Peritonitis (HP:0002586)5.68209420
7Aortic dissection (HP:0002647)5.51621448
8Dilatation of the ascending aorta (HP:0005111)5.32174057
9Vertebral compression fractures (HP:0002953)5.05823703
10Ankle contracture (HP:0006466)4.71210527
11Wormian bones (HP:0002645)4.71120456
12Bowel diverticulosis (HP:0005222)4.57899044
13Shallow orbits (HP:0000586)4.37012919
14Atrophic scars (HP:0001075)4.36017013
15Broad metatarsal (HP:0001783)4.33984803
16Biconcave vertebral bodies (HP:0004586)4.29174759
17Arterial tortuosity (HP:0005116)4.29024699
18Abnormality of dentin (HP:0010299)4.23173819
19Overgrowth (HP:0001548)4.21170670
20Fragile skin (HP:0001030)4.06131522
21Cerebral aneurysm (HP:0004944)3.99898505
22Genu recurvatum (HP:0002816)3.88542138
23Blue sclerae (HP:0000592)3.72145719
24Cervical subluxation (HP:0003308)3.65754004
25Wrist flexion contracture (HP:0001239)3.49676051
26Follicular hyperkeratosis (HP:0007502)3.41166401
27Spinal rigidity (HP:0003306)3.25672606
28Aneurysm (HP:0002617)3.20495031
29Abnormal delivery (HP:0001787)3.18043918
30Neonatal short-limb short stature (HP:0008921)3.17127565
31Acanthosis nigricans (HP:0000956)3.14099154
32Type 1 muscle fiber predominance (HP:0003803)3.12453473
33Hyperextensible skin (HP:0000974)3.04844427
34Mitral valve prolapse (HP:0001634)3.02504186
35Ulnar deviation of the wrist (HP:0003049)2.98032692
36Oligomenorrhea (HP:0000876)2.92215862
37Infantile muscular hypotonia (HP:0008947)2.90769849
38Joint stiffness (HP:0001387)2.85397473
39Abnormality of the acetabulum (HP:0003170)2.81504107
40Mitral regurgitation (HP:0001653)2.79926341
41Ectopia lentis (HP:0001083)2.78773959
42Cerebellar dysplasia (HP:0007033)2.74336345
43Retinal atrophy (HP:0001105)2.73950451
44Spondylolisthesis (HP:0003302)2.73078484
45Coxa vara (HP:0002812)2.72021913
46Increased connective tissue (HP:0009025)2.69683076
47Testicular atrophy (HP:0000029)2.63262216
48Elbow flexion contracture (HP:0002987)2.57881342
49Aortic valve stenosis (HP:0001650)2.57198327
50Beaking of vertebral bodies (HP:0004568)2.54084427
51Thin bony cortex (HP:0002753)2.47060677
52Slender build (HP:0001533)2.46671913
53Joint laxity (HP:0001388)2.45927191
54Breech presentation (HP:0001623)2.43306720
55Hypoplasia of the odontoid process (HP:0003311)2.41358463
56Abnormality of the peritoneum (HP:0002585)2.39609427
57Abnormality of polysaccharide metabolism (HP:0011012)2.34630627
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34630627
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34630627
60Round ear (HP:0100830)2.34586913
61Nonimmune hydrops fetalis (HP:0001790)2.33172808
62Broad ribs (HP:0000885)2.31124518
63Mesangial abnormality (HP:0001966)2.31047413
64Mucopolysacchariduria (HP:0008155)2.28211874
65Urinary glycosaminoglycan excretion (HP:0003541)2.28211874
66Hypercortisolism (HP:0001578)2.26827149
67Emphysema (HP:0002097)2.26397370
68Ulnar claw (HP:0001178)2.24014192
69Atelectasis (HP:0100750)2.23759052
70Mitral stenosis (HP:0001718)2.22996866
71Coronal craniosynostosis (HP:0004440)2.22839470
72Increased variability in muscle fiber diameter (HP:0003557)2.19645301
73Bulbous nose (HP:0000414)2.19256616
74Osteoarthritis (HP:0002758)2.17697727
75Sparse lateral eyebrow (HP:0005338)2.15885661
76Abnormality of complement system (HP:0005339)2.15556599
77Complement deficiency (HP:0004431)2.15266641
78Mildly elevated creatine phosphokinase (HP:0008180)2.14837677
79Congenital glaucoma (HP:0001087)2.14567180
80Pulmonary artery stenosis (HP:0004415)2.13946760
81Premature skin wrinkling (HP:0100678)2.12383974
82J-shaped sella turcica (HP:0002680)2.12286416
83Abnormality of the anterior chamber (HP:0000593)2.12043075
84Osteolytic defects of the hand bones (HP:0009699)2.11987398
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.11987398
86Bell-shaped thorax (HP:0001591)2.09992291
87Redundant skin (HP:0001582)2.09913191
88Venous insufficiency (HP:0005293)2.05860336
89Hypertriglyceridemia (HP:0002155)2.04223917
90Entropion (HP:0000621)2.04152235
91Venous abnormality (HP:0002624)2.03920980
92Bradycardia (HP:0001662)2.03636843
93Bone cyst (HP:0012062)2.02337495
94Camptodactyly of toe (HP:0001836)2.01325478
95Short nail (HP:0001799)2.00986186
96Wide anterior fontanel (HP:0000260)2.00676818
97Distal lower limb muscle weakness (HP:0009053)2.00416524
98Protrusio acetabuli (HP:0003179)10.2822590
99Abnormality of the odontoid process (HP:0003310)1.99140877
100Concave nail (HP:0001598)1.98697385
101Inguinal hernia (HP:0000023)1.96257355
102Aortic regurgitation (HP:0001659)1.93207238
103Decreased skull ossification (HP:0004331)1.92405664
104Abnormality of skull ossification (HP:0002703)1.92019708
105Deviation of the hallux (HP:0010051)1.91998713
106Abnormality of skeletal muscle fiber size (HP:0012084)1.91331770
107Increased corneal curvature (HP:0100692)1.89672805
108Keratoconus (HP:0000563)1.89672805
109Rectal prolapse (HP:0002035)1.89437451
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89155455
111Abnormality of alanine metabolism (HP:0010916)1.89155455
112Hyperalaninemia (HP:0003348)1.89155455
113Hallux valgus (HP:0001822)1.87224366
114Reduced subcutaneous adipose tissue (HP:0003758)1.86745720
115Hyporeflexia of lower limbs (HP:0002600)1.83839360
116Tibial bowing (HP:0002982)1.83622726
117Thin skin (HP:0000963)1.81752750
118Osteopenia (HP:0000938)1.81391763
119Asymmetric septal hypertrophy (HP:0001670)1.80355319
120Back pain (HP:0003418)1.79415099
121Persistence of primary teeth (HP:0006335)1.78672127
122Striae distensae (HP:0001065)1.78314249
123Platyspondyly (HP:0000926)1.77516743
124Systemic lupus erythematosus (HP:0002725)1.76331974
125Generalized amyotrophy (HP:0003700)1.76246472
126Delayed closure of the anterior fontanelle (HP:0001476)1.76096987
127Delayed cranial suture closure (HP:0000270)1.75856039
128Buphthalmos (HP:0000557)1.75618045
129Mild short stature (HP:0003502)1.73083408
130Distal upper limb amyotrophy (HP:0007149)1.72817853
131Upper limb amyotrophy (HP:0009129)1.72817853
132Arachnodactyly (HP:0001166)1.72216772
133Spinal cord compression (HP:0002176)1.65905126
134Femoral bowing (HP:0002980)1.65145321
135Hand muscle atrophy (HP:0009130)1.64681330
136Ovoid vertebral bodies (HP:0003300)1.62879673
137Cardiovascular calcification (HP:0011915)1.62622065
138Full cheeks (HP:0000293)1.61514445
139Achilles tendon contracture (HP:0001771)1.59022096
140Increased density of long bones (HP:0006392)1.57668537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.52826281
2DDR24.59008593
3ERN14.07311679
4EPHA33.76965725
5TRIB33.67454836
6PDGFRA3.59484543
7TTN3.46425272
8MAP2K22.59376333
9MUSK2.50935460
10PKN22.26331710
11MYLK2.05613038
12RPS6KA42.04656180
13PAK32.04027874
14TIE11.97675352
15FER1.97205263
16RPS6KB21.91801783
17TESK11.87534679
18EPHB21.76614750
19PAK21.71143774
20TLK11.69298136
21WNK41.64048366
22LIMK11.49839475
23ICK1.44001158
24FLT31.41564718
25TRPM71.40929831
26LATS11.37564376
27PIM21.37198094
28GRK51.36711851
29GRK11.35720100
30PTK21.34576342
31NTRK11.34108766
32PIK3CA1.32610288
33EPHB11.30590130
34MOS1.29791126
35KIT1.28723198
36ERBB31.27822209
37PTK2B1.24106029
38NME21.23275119
39CAMK11.21384038
40ARAF1.19580893
41PIK3CG1.18075504
42ADRBK21.17646422
43MET1.17644664
44MAPK121.15633191
45PLK21.14886391
46VRK21.14649296
47MAP2K11.14466699
48NEK61.13023508
49FRK1.11709586
50GRK61.09679921
51MAPK71.09404399
52NEK91.08188308
53ABL21.06633432
54TGFBR21.04058049
55LRRK21.03469281
56ROCK11.02226884
57PAK41.02183023
58RIPK11.00398935
59FGFR10.99691857
60CAMKK20.99081722
61DMPK0.98362934
62PDGFRB0.97453125
63RPS6KA20.96074099
64TAOK10.93952152
65PRKAA20.92657781
66PDPK10.91928053
67SIK10.90751763
68PAK10.89701522
69FGFR40.88836057
70PINK10.87112690
71ILK0.84910649
72CAMK2G0.84871591
73SCYL20.84412114
74STK390.83208484
75MAP3K60.83057988
76MAPK40.82898396
77HIPK20.80669228
78STK380.80471374
79BMX0.79340757
80TESK20.78706898
81MARK30.78361129
82JAK10.77515625
83PRKD10.77092962
84MAP3K30.76278863
85JAK30.73035128
86PDK20.71199555
87DAPK30.67941009
88MAPK110.67312999
89ZAK0.66899034
90MAPKAPK50.66174841
91TAOK20.66105036
92INSRR0.64900424
93PRKD30.62519429
94CAMK2D0.61849698
95PTK60.58029157
96CDC42BPA0.57498181
97PHKG20.57397785
98PHKG10.57397785
99MAP2K30.57173139
100RPS6KA60.57118810
101INSR0.56361448
102PDK30.56040328
103PDK40.56040328
104STK30.55779414
105NME10.55750568
106RET0.55504365
107CAMKK10.54881989
108CAMK2B0.52639185
109PRKCE0.52380704
110MAPK150.51418421
111MTOR0.51255622
112STK38L0.50381773
113KSR20.49516521
114IKBKB0.48381413
115MELK0.48144489
116TBK10.48132494
117MAPKAPK30.47885795
118ROCK20.47427578
119PRKAA10.46778511
120KDR0.46548837
121RPS6KL10.45652604
122RPS6KC10.45652604
123RPS6KA50.45513883
124MST1R0.45043927
125GSK3A0.44855751
126PRKD20.44427724
127RAF10.44325176
128TYK20.44102106
129PRKCI0.42609595
130CDK140.39035366
131MAPK30.38915966
132AKT20.38687610
133PKN10.38614764
134CDK150.38119306
135MAP3K130.37236710
136BCKDK0.36821800
137PRKG20.36103242
138PRKCH0.35494531
139MAPKAPK20.35410833
140NUAK10.35157717
141PAK60.35085857
142ADRBK10.34580312
143FGFR20.33632757
144CDK180.33385322
145SRC0.32893056
146CDK11A0.32166090
147MAP2K60.30766827
148TGFBR10.30695699
149FGFR30.29473964
150CDK60.26979898
151PLK30.26737920
152EEF2K0.24445680

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.77501634
2ECM-receptor interaction_Homo sapiens_hsa045124.64476709
3Malaria_Homo sapiens_hsa051443.46383267
4Focal adhesion_Homo sapiens_hsa045103.37272790
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.06156074
6Sulfur relay system_Homo sapiens_hsa041222.87436220
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.55920617
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.46091376
9Protein digestion and absorption_Homo sapiens_hsa049742.43652948
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.41482682
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.33653200
12Phenylalanine metabolism_Homo sapiens_hsa003602.30264457
13PPAR signaling pathway_Homo sapiens_hsa033202.22192510
14Proteoglycans in cancer_Homo sapiens_hsa052052.18910599
15Dilated cardiomyopathy_Homo sapiens_hsa054142.13873950
16Tyrosine metabolism_Homo sapiens_hsa003502.09843407
17TGF-beta signaling pathway_Homo sapiens_hsa043502.06388664
18Amoebiasis_Homo sapiens_hsa051461.88829475
19ABC transporters_Homo sapiens_hsa020101.87523839
20Bladder cancer_Homo sapiens_hsa052191.86314578
21Adherens junction_Homo sapiens_hsa045201.79213192
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.77157788
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73380722
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73351774
25Nitrogen metabolism_Homo sapiens_hsa009101.69608258
26Caffeine metabolism_Homo sapiens_hsa002321.62321967
27Glycerolipid metabolism_Homo sapiens_hsa005611.58349613
28Melanoma_Homo sapiens_hsa052181.56660676
29Tryptophan metabolism_Homo sapiens_hsa003801.55043078
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47569945
31Shigellosis_Homo sapiens_hsa051311.46249738
32Phagosome_Homo sapiens_hsa041451.45766043
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45004642
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.43344059
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43316735
36beta-Alanine metabolism_Homo sapiens_hsa004101.42775605
37Histidine metabolism_Homo sapiens_hsa003401.37795637
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36824054
39Hippo signaling pathway_Homo sapiens_hsa043901.32089346
40Fatty acid degradation_Homo sapiens_hsa000711.31170890
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28859209
42TNF signaling pathway_Homo sapiens_hsa046681.28561592
43AMPK signaling pathway_Homo sapiens_hsa041521.28401796
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.26370896
45MicroRNAs in cancer_Homo sapiens_hsa052061.24620918
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.18200455
47Pyruvate metabolism_Homo sapiens_hsa006201.17904787
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.17264106
49HIF-1 signaling pathway_Homo sapiens_hsa040661.15693997
50Platelet activation_Homo sapiens_hsa046111.14650006
51Morphine addiction_Homo sapiens_hsa050321.13913054
52Chronic myeloid leukemia_Homo sapiens_hsa052201.13519047
53Lysosome_Homo sapiens_hsa041421.12073436
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11627358
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11578502
56Arachidonic acid metabolism_Homo sapiens_hsa005901.07304825
57Rap1 signaling pathway_Homo sapiens_hsa040151.06967178
58Rheumatoid arthritis_Homo sapiens_hsa053231.03609753
59Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03298465
60Small cell lung cancer_Homo sapiens_hsa052221.03281522
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99655301
62Pancreatic cancer_Homo sapiens_hsa052120.97303510
63Glioma_Homo sapiens_hsa052140.96503332
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90879511
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.90466220
66Fatty acid elongation_Homo sapiens_hsa000620.90188360
67Circadian rhythm_Homo sapiens_hsa047100.90029670
68N-Glycan biosynthesis_Homo sapiens_hsa005100.89853877
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89748310
70Viral myocarditis_Homo sapiens_hsa054160.87818015
71Vibrio cholerae infection_Homo sapiens_hsa051100.87585603
72p53 signaling pathway_Homo sapiens_hsa041150.87136960
73Galactose metabolism_Homo sapiens_hsa000520.84574280
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84293376
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.82929683
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82192604
77Apoptosis_Homo sapiens_hsa042100.82077126
78Pathways in cancer_Homo sapiens_hsa052000.81932261
79Sulfur metabolism_Homo sapiens_hsa009200.81883913
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.81154346
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.78909770
82Salmonella infection_Homo sapiens_hsa051320.78722177
83Linoleic acid metabolism_Homo sapiens_hsa005910.78290068
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78197294
85Pentose phosphate pathway_Homo sapiens_hsa000300.77283307
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75779791
87Arginine and proline metabolism_Homo sapiens_hsa003300.75743484
88HTLV-I infection_Homo sapiens_hsa051660.75114172
89Prostate cancer_Homo sapiens_hsa052150.73630890
90Renin secretion_Homo sapiens_hsa049240.72396291
91Complement and coagulation cascades_Homo sapiens_hsa046100.72065885
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71731539
93Renal cell carcinoma_Homo sapiens_hsa052110.71434348
94Prion diseases_Homo sapiens_hsa050200.71005764
95Gap junction_Homo sapiens_hsa045400.69939970
96Fat digestion and absorption_Homo sapiens_hsa049750.69390883
97Toxoplasmosis_Homo sapiens_hsa051450.69217605
98Basal cell carcinoma_Homo sapiens_hsa052170.68299510
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66731414
100Ras signaling pathway_Homo sapiens_hsa040140.66724970
101Arginine biosynthesis_Homo sapiens_hsa002200.64647981
102Pertussis_Homo sapiens_hsa051330.63979823
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.63807314
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63524610
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62070611
106Tight junction_Homo sapiens_hsa045300.61836019
107Wnt signaling pathway_Homo sapiens_hsa043100.60122232
108Propanoate metabolism_Homo sapiens_hsa006400.59732711
109Hepatitis B_Homo sapiens_hsa051610.59558389
110Peroxisome_Homo sapiens_hsa041460.58215387
111Other glycan degradation_Homo sapiens_hsa005110.57410958
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56969019
113Axon guidance_Homo sapiens_hsa043600.55390798
114Oxidative phosphorylation_Homo sapiens_hsa001900.54356268
115Butanoate metabolism_Homo sapiens_hsa006500.53346630
116Lysine degradation_Homo sapiens_hsa003100.52458207
117Legionellosis_Homo sapiens_hsa051340.51180851
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.50946486
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49685721
120Viral carcinogenesis_Homo sapiens_hsa052030.49562261
121Glutathione metabolism_Homo sapiens_hsa004800.49182555
122Cardiac muscle contraction_Homo sapiens_hsa042600.48833458
123Hedgehog signaling pathway_Homo sapiens_hsa043400.48263906
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48154896
125Glucagon signaling pathway_Homo sapiens_hsa049220.48084792
126Starch and sucrose metabolism_Homo sapiens_hsa005000.47887017
127Endocytosis_Homo sapiens_hsa041440.47528096
128Retinol metabolism_Homo sapiens_hsa008300.47341846
129Thyroid hormone synthesis_Homo sapiens_hsa049180.45586682
130Osteoclast differentiation_Homo sapiens_hsa043800.42054167
131Chemical carcinogenesis_Homo sapiens_hsa052040.41780015
132Alzheimers disease_Homo sapiens_hsa050100.40597996
133Leishmaniasis_Homo sapiens_hsa051400.39909937
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39379785
135Phototransduction_Homo sapiens_hsa047440.38820234
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38641690
137Tuberculosis_Homo sapiens_hsa051520.36979391
138Insulin signaling pathway_Homo sapiens_hsa049100.36786656
139Purine metabolism_Homo sapiens_hsa002300.36649589
140Protein export_Homo sapiens_hsa030600.36605443
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.36513970
142Ovarian steroidogenesis_Homo sapiens_hsa049130.35655129
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35175607
144mTOR signaling pathway_Homo sapiens_hsa041500.34529445
145VEGF signaling pathway_Homo sapiens_hsa043700.34429411
146Metabolic pathways_Homo sapiens_hsa011000.34025235
147Vitamin B6 metabolism_Homo sapiens_hsa007500.33513207
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32971488
149GnRH signaling pathway_Homo sapiens_hsa049120.32962639
150Insulin resistance_Homo sapiens_hsa049310.32716705
151Colorectal cancer_Homo sapiens_hsa052100.31929031
152cAMP signaling pathway_Homo sapiens_hsa040240.31889285
153Estrogen signaling pathway_Homo sapiens_hsa049150.31137230
154Folate biosynthesis_Homo sapiens_hsa007900.30560781
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.29903582
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29687186
157Regulation of autophagy_Homo sapiens_hsa041400.29547608
158Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28817466
159Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26955847
160Melanogenesis_Homo sapiens_hsa049160.26543155
161FoxO signaling pathway_Homo sapiens_hsa040680.25809051
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24482538

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