WISP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)8.47398655
2notochord development (GO:0030903)8.47035922
3negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.59010786
4limb bud formation (GO:0060174)6.36737086
5collagen fibril organization (GO:0030199)6.15949986
6response to pheromone (GO:0019236)5.91525460
7positive regulation of extracellular matrix organization (GO:1903055)5.76921605
8sphingomyelin metabolic process (GO:0006684)5.56166577
9proteoglycan metabolic process (GO:0006029)5.44738284
10chondroitin sulfate biosynthetic process (GO:0030206)5.35976670
11cartilage development (GO:0051216)5.13329481
12replacement ossification (GO:0036075)5.06368353
13endochondral ossification (GO:0001958)5.06368353
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.03431114
15embryonic skeletal joint morphogenesis (GO:0060272)4.93044131
16fat-soluble vitamin biosynthetic process (GO:0042362)4.76104498
17embryonic viscerocranium morphogenesis (GO:0048703)4.72914557
18lipopolysaccharide biosynthetic process (GO:0009103)4.68139509
19cellular glucuronidation (GO:0052695)4.64173352
20negative regulation of gluconeogenesis (GO:0045721)4.60627049
21nucleotide-sugar biosynthetic process (GO:0009226)4.55578116
22chondrocyte differentiation (GO:0002062)4.43496473
23positive regulation of hormone biosynthetic process (GO:0046886)4.38548815
24epithelial cilium movement (GO:0003351)4.26597675
25detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.26407063
26regulation of extracellular matrix disassembly (GO:0010715)4.22098725
27skeletal system development (GO:0001501)4.16886768
28behavioral response to nicotine (GO:0035095)4.14286346
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.14172257
30protein retention in ER lumen (GO:0006621)4.09546576
31sperm motility (GO:0030317)4.09138843
32regulation of plasminogen activation (GO:0010755)4.07347113
33positive regulation of chondrocyte differentiation (GO:0032332)4.04470874
34fusion of sperm to egg plasma membrane (GO:0007342)3.99409429
35response to gravity (GO:0009629)3.98635430
36myelin assembly (GO:0032288)3.98131204
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.97066626
38DNA deamination (GO:0045006)3.93943593
39hypotonic response (GO:0006971)3.93616627
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.91425345
41iron ion import (GO:0097286)3.90546866
42glucuronate metabolic process (GO:0019585)3.89201992
43uronic acid metabolic process (GO:0006063)3.89201992
44acrosome reaction (GO:0007340)3.88490927
45cilium or flagellum-dependent cell motility (GO:0001539)3.87198839
46protein polyglutamylation (GO:0018095)3.85819921
47keratan sulfate biosynthetic process (GO:0018146)3.80379040
48lipopolysaccharide metabolic process (GO:0008653)3.79575074
49piRNA metabolic process (GO:0034587)3.75426724
50collagen catabolic process (GO:0030574)3.73843891
51connective tissue development (GO:0061448)3.72553748
52short-term memory (GO:0007614)3.71193196
53negative regulation of thymocyte apoptotic process (GO:0070244)3.63527625
54negative regulation of smooth muscle cell differentiation (GO:0051151)3.63255797
55protein complex biogenesis (GO:0070271)3.59643828
56collagen metabolic process (GO:0032963)3.59193392
57L-fucose catabolic process (GO:0042355)3.59117759
58fucose catabolic process (GO:0019317)3.59117759
59L-fucose metabolic process (GO:0042354)3.59117759
60regulation of cilium movement (GO:0003352)3.55533769
61axonemal dynein complex assembly (GO:0070286)3.54557058
62cilium movement (GO:0003341)3.53185078
63DNA strand renaturation (GO:0000733)3.52012588
64water-soluble vitamin biosynthetic process (GO:0042364)3.44816865
65cellular ketone body metabolic process (GO:0046950)3.44409228
66male meiosis (GO:0007140)3.41978976
67endocardial cushion morphogenesis (GO:0003203)3.41097256
68hyperosmotic salinity response (GO:0042538)3.40418093
69multicellular organismal catabolic process (GO:0044243)3.39541268
70neurofilament cytoskeleton organization (GO:0060052)3.38943051
71multicellular organism reproduction (GO:0032504)3.37408644
72multicellular organismal macromolecule metabolic process (GO:0044259)3.36555366
73dopamine transport (GO:0015872)3.36525975
74positive regulation of cartilage development (GO:0061036)3.36185549
75glycoprotein metabolic process (GO:0009100)3.33463729
76indolalkylamine metabolic process (GO:0006586)3.30337991
77regulation of extracellular matrix organization (GO:1903053)3.29868294
78axoneme assembly (GO:0035082)3.29387674
79mitochondrial respiratory chain complex assembly (GO:0033108)3.28876919
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27634642
81mitochondrial respiratory chain complex I assembly (GO:0032981)3.27634642
82NADH dehydrogenase complex assembly (GO:0010257)3.27634642
83plasma membrane fusion (GO:0045026)3.26976302
84male meiosis I (GO:0007141)3.26580533
85COPII vesicle coating (GO:0048208)3.25359803
86cytochrome complex assembly (GO:0017004)3.25241879
87glucocorticoid receptor signaling pathway (GO:0042921)3.24474380
88response to BMP (GO:0071772)3.23367981
89cellular response to BMP stimulus (GO:0071773)3.23367981
90endothelial cell morphogenesis (GO:0001886)3.21781033
91positive regulation of action potential (GO:0045760)3.20848985
92negative regulation of telomere maintenance (GO:0032205)3.19676703
93tryptophan catabolic process (GO:0006569)3.18790269
94indole-containing compound catabolic process (GO:0042436)3.18790269
95indolalkylamine catabolic process (GO:0046218)3.18790269
96multicellular organismal metabolic process (GO:0044236)3.18639410
97DNA methylation involved in gamete generation (GO:0043046)3.17087707
98alternative mRNA splicing, via spliceosome (GO:0000380)3.15664565
99kinetochore organization (GO:0051383)3.13336081
100nonmotile primary cilium assembly (GO:0035058)3.12957421
101positive regulation of megakaryocyte differentiation (GO:0045654)3.12699133
102V(D)J recombination (GO:0033151)3.11162378
103sister chromatid segregation (GO:0000819)3.10895251
104respiratory chain complex IV assembly (GO:0008535)3.09560258
105chaperone-mediated protein transport (GO:0072321)3.09442761
106regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.09326410
107bone development (GO:0060348)3.09068608
108positive regulation of neurological system process (GO:0031646)3.08572689
109activated T cell proliferation (GO:0050798)3.07709181
110ketone body metabolic process (GO:1902224)3.07482415
111negative regulation of chemokine production (GO:0032682)3.04510246
112magnesium ion transport (GO:0015693)3.03792821
113regulation of action potential (GO:0098900)3.01698004
114detection of mechanical stimulus involved in sensory perception (GO:0050974)3.00729956
115centriole replication (GO:0007099)3.00393833
116platelet dense granule organization (GO:0060155)2.99192568
117nephron epithelium morphogenesis (GO:0072088)2.99082662
118nephron tubule morphogenesis (GO:0072078)2.99082662
119detection of light stimulus involved in visual perception (GO:0050908)2.97964350
120detection of light stimulus involved in sensory perception (GO:0050962)2.97964350
121positive regulation of hormone metabolic process (GO:0032352)2.96506956
122tryptophan metabolic process (GO:0006568)2.95880374
123kynurenine metabolic process (GO:0070189)2.94356569
124microtubule depolymerization (GO:0007019)2.93430459
125neuronal action potential (GO:0019228)2.93134241
126regulation of hexokinase activity (GO:1903299)2.92897761
127regulation of glucokinase activity (GO:0033131)2.92897761
128mitotic nuclear envelope disassembly (GO:0007077)2.90172686
129glycosaminoglycan biosynthetic process (GO:0006024)2.87300872
130protein-cofactor linkage (GO:0018065)2.85722631
131cilium organization (GO:0044782)2.83024905
132regulation of cell maturation (GO:1903429)2.83017687
133aminoglycan biosynthetic process (GO:0006023)2.82584804
134protein localization to kinetochore (GO:0034501)2.82127563
135spermatid development (GO:0007286)2.81483434
136UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80757426
137regulation of response to osmotic stress (GO:0047484)2.79400554
138negative regulation of histone methylation (GO:0031061)2.78756219
139keratan sulfate metabolic process (GO:0042339)2.78628024
140positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.77983352
141retinal cone cell development (GO:0046549)2.77566666
142cilium assembly (GO:0042384)2.77353085
143translesion synthesis (GO:0019985)2.76925208
144regulation of mesoderm development (GO:2000380)2.76911375
145negative regulation of alcohol biosynthetic process (GO:1902931)2.75070217
146intra-S DNA damage checkpoint (GO:0031573)2.75021642
147chondrocyte proliferation (GO:0035988)2.73978487
148regulation of microtubule-based movement (GO:0060632)2.73178542
149mitotic sister chromatid cohesion (GO:0007064)2.72844920
150mesenchyme morphogenesis (GO:0072132)2.72797708
151photoreceptor cell development (GO:0042461)2.72121869
152proteoglycan biosynthetic process (GO:0030166)2.70914437
153mitotic sister chromatid segregation (GO:0000070)2.70739889
154calcium ion-dependent exocytosis (GO:0017156)2.70517835
155sperm-egg recognition (GO:0035036)2.70246038
156peptidyl-proline hydroxylation (GO:0019511)2.69993926
157protein peptidyl-prolyl isomerization (GO:0000413)2.69822958
158preassembly of GPI anchor in ER membrane (GO:0016254)2.67666022
159cilium morphogenesis (GO:0060271)2.67213204
160chondroitin sulfate metabolic process (GO:0030204)2.65900339
161IMP biosynthetic process (GO:0006188)2.65516236
162ATP synthesis coupled proton transport (GO:0015986)2.65424756
163energy coupled proton transport, down electrochemical gradient (GO:0015985)2.65424756
164regulation of acrosome reaction (GO:0060046)2.65250795
165reciprocal DNA recombination (GO:0035825)2.65076493
166reciprocal meiotic recombination (GO:0007131)2.65076493
167regulation of hormone biosynthetic process (GO:0046885)2.64624785
168positive regulation of sodium ion transmembrane transport (GO:1902307)2.64546479
169corticosteroid receptor signaling pathway (GO:0031958)2.64024476
170extracellular matrix disassembly (GO:0022617)2.64011611
171rhodopsin mediated signaling pathway (GO:0016056)2.63613866
172regulation of type B pancreatic cell apoptotic process (GO:2000674)2.62923562
173membrane disassembly (GO:0030397)2.62892170
174nuclear envelope disassembly (GO:0051081)2.62892170
175synapsis (GO:0007129)2.62513055
176indole-containing compound metabolic process (GO:0042430)2.60614145
177mannosylation (GO:0097502)2.57687062
178protein localization to cilium (GO:0061512)2.56653720
179tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53938847
180RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53938847
181cornea development in camera-type eye (GO:0061303)2.51845775
182behavioral response to ethanol (GO:0048149)2.50358582
183parturition (GO:0007567)2.49364648
184regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48001305
185positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47561565
186mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46868454
187photoreceptor cell maintenance (GO:0045494)2.45316795
188reflex (GO:0060004)2.44002659
189signal peptide processing (GO:0006465)2.43812525
190intracellular protein transmembrane import (GO:0044743)2.43670503
191cellular biogenic amine catabolic process (GO:0042402)2.41039812
192amine catabolic process (GO:0009310)2.41039812
193microtubule polymerization or depolymerization (GO:0031109)2.39862491
194meiosis I (GO:0007127)2.39633087
195cartilage development involved in endochondral bone morphogenesis (GO:0060351)11.8096679
196chondrocyte development (GO:0002063)10.7218884
197cartilage condensation (GO:0001502)10.6453318
198cell aggregation (GO:0098743)10.6453318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.24592150
2AR_21572438_ChIP-Seq_LNCaP_Human4.92062291
3GATA1_22025678_ChIP-Seq_K562_Human3.97364587
4ZNF274_21170338_ChIP-Seq_K562_Hela3.89784274
5VDR_22108803_ChIP-Seq_LS180_Human3.44790068
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.43759377
7AR_21909140_ChIP-Seq_LNCAP_Human3.03296298
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90834235
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.56454948
10EZH2_22144423_ChIP-Seq_EOC_Human2.52628644
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.42171157
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.32825298
13FUS_26573619_Chip-Seq_HEK293_Human2.31540338
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28440269
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.28094200
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21599886
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15177106
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.12099881
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11958515
20IGF1R_20145208_ChIP-Seq_DFB_Human2.07414290
21E2F7_22180533_ChIP-Seq_HELA_Human10.7219174
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97989446
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97459650
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97368148
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90660155
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90403641
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.88641258
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86882935
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.86501746
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82311609
31ER_23166858_ChIP-Seq_MCF-7_Human1.79940097
32MYC_22102868_ChIP-Seq_BL_Human1.76990317
33* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72525535
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69869764
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69377781
36CBP_20019798_ChIP-Seq_JUKART_Human1.69377781
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68934653
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64515588
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63515869
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.62756834
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62667800
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62626542
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62626542
44TAF15_26573619_Chip-Seq_HEK293_Human1.62455338
45TP53_22573176_ChIP-Seq_HFKS_Human1.57802883
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57092127
47EWS_26573619_Chip-Seq_HEK293_Human1.54450285
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.53021216
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53019432
50GBX2_23144817_ChIP-Seq_PC3_Human1.50633811
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49497490
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47956030
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46660557
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45890127
55SMAD4_21799915_ChIP-Seq_A2780_Human1.45478310
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.44956994
57STAT3_23295773_ChIP-Seq_U87_Human1.43911689
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43293656
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42770006
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.42770006
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42360528
62AR_25329375_ChIP-Seq_VCAP_Human1.42293237
63IRF1_19129219_ChIP-ChIP_H3396_Human1.41448376
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.40501284
65BCAT_22108803_ChIP-Seq_LS180_Human1.40260418
66ELK1_19687146_ChIP-ChIP_HELA_Human1.38151647
67NANOG_19829295_ChIP-Seq_ESCs_Human1.37966990
68SOX2_19829295_ChIP-Seq_ESCs_Human1.37966990
69* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37677163
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37469287
71TCF4_23295773_ChIP-Seq_U87_Human1.34904195
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33177677
73SCL_19346495_ChIP-Seq_HPC-7_Human1.31026849
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.29872180
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28161965
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25125008
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.24652817
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.24618190
79MYC_18940864_ChIP-ChIP_HL60_Human1.23852692
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23421659
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23360223
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23203806
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22834056
84CJUN_26792858_Chip-Seq_BT549_Human1.22250747
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21852831
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21628117
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20723692
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20305882
89REST_21632747_ChIP-Seq_MESCs_Mouse1.19524013
90RUNX2_22187159_ChIP-Seq_PCA_Human1.19486098
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18433929
92* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18432753
93NCOR_22424771_ChIP-Seq_293T_Human1.18051577
94ERA_21632823_ChIP-Seq_H3396_Human1.17484763
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.17150580
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16991154
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16092884
98HOXB7_26014856_ChIP-Seq_BT474_Human1.14568048
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.14484832
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13253481
101RNF2_27304074_Chip-Seq_NSC_Mouse1.12027817
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11673059
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10702786
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09322964
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.09125087
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08963308
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08928508
108TAF2_19829295_ChIP-Seq_ESCs_Human1.08210839
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08033135
110P53_22387025_ChIP-Seq_ESCs_Mouse1.07590523
111* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07039304
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06822063
113* AR_20517297_ChIP-Seq_VCAP_Human1.05939368
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05532462
115TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04079243
116VDR_23849224_ChIP-Seq_CD4+_Human1.03878613
117WDR5_24793694_ChIP-Seq_LNCAP_Human1.03457246
118* NANOG_20526341_ChIP-Seq_ESCs_Human1.02815711
119EGR1_19032775_ChIP-ChIP_M12_Human1.02563414
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02251210
121* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01995856
122GF1B_26923725_Chip-Seq_HPCs_Mouse1.01264990
123PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01209723
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01204838
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00903951
126TCF4_22108803_ChIP-Seq_LS180_Human1.00610447
127* FLI1_21867929_ChIP-Seq_TH2_Mouse1.00424407
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.00166413
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99949393
130VDR_24787735_ChIP-Seq_THP-1_Human0.98887213
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96183247
132TTF2_22483619_ChIP-Seq_HELA_Human0.94695443
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.94601027
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.91890271
135RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91172330
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89970083
137TP63_17297297_ChIP-ChIP_HaCaT_Human0.89270916
138NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88812761
139* EZH2_27294783_Chip-Seq_NPCs_Mouse0.88693593
140MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88348683
141GF1_26923725_Chip-Seq_HPCs_Mouse0.87062814
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86548758
143KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.86512585
144ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84708368
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84325206
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84226162
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.82962625
148* BRD4_25478319_ChIP-Seq_HGPS_Human0.82076359
149CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82047947
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81753818
151EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80727884
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80142956
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79967092
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79854834
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.78440606
156ELK1_22589737_ChIP-Seq_MCF10A_Human0.77373614
157* P300_19829295_ChIP-Seq_ESCs_Human0.76985248
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.76732056
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.74485411
160CIITA_25753668_ChIP-Seq_RAJI_Human0.73605325
161TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.73562920
162KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72400654
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.69558617
164CLOCK_20551151_ChIP-Seq_293T_Human0.68665087
165STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.68110308
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.67287267
167ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66430975
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.66196874
169CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65129136
170OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.65057962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation5.91000626
2MP0004134_abnormal_chest_morphology5.78332184
3MP0003646_muscle_fatigue4.50239535
4MP0002282_abnormal_trachea_morphology4.48348461
5MP0009250_abnormal_appendicular_skeleto3.88093261
6MP0005503_abnormal_tendon_morphology3.76772640
7MP0000163_abnormal_cartilage_morphology3.66329751
8MP0003123_paternal_imprinting3.50440486
9MP0003195_calcinosis3.40982225
10MP0009780_abnormal_chondrocyte_physiolo3.18273854
11MP0002115_abnormal_skeleton_extremities3.00386235
12MP0005410_abnormal_fertilization2.91057289
13MP0006292_abnormal_olfactory_placode2.60714668
14MP0002113_abnormal_skeleton_development2.51542681
15MP0003787_abnormal_imprinting2.44149634
16MP0002089_abnormal_postnatal_growth/wei2.34648804
17MP0002909_abnormal_adrenal_gland2.30274705
18MP0003121_genomic_imprinting2.18434476
19MP0005084_abnormal_gallbladder_morpholo2.12306370
20MP0005377_hearing/vestibular/ear_phenot2.11146829
21MP0003878_abnormal_ear_physiology2.11146829
22MP0008995_early_reproductive_senescence2.07727121
23MP0002109_abnormal_limb_morphology2.05436563
24MP0002163_abnormal_gland_morphology1.98962090
25MP0002102_abnormal_ear_morphology1.98439972
26MP0008872_abnormal_physiological_respon1.91416314
27MP0003656_abnormal_erythrocyte_physiolo1.86814859
28MP0001968_abnormal_touch/_nociception1.86149374
29MP0001270_distended_abdomen1.84973933
30MP0004885_abnormal_endolymph1.83582119
31MP0001986_abnormal_taste_sensitivity1.83120650
32MP0005508_abnormal_skeleton_morphology1.82135941
33MP0000372_irregular_coat_pigmentation1.81893165
34MP0000762_abnormal_tongue_morphology1.80610248
35MP0004043_abnormal_pH_regulation1.80417833
36MP0004142_abnormal_muscle_tone1.80389290
37MP0009384_cardiac_valve_regurgitation1.80055607
38MP0003011_delayed_dark_adaptation1.78462083
39MP0009745_abnormal_behavioral_response1.74364712
40MP0000751_myopathy1.74313761
41MP0002896_abnormal_bone_mineralization1.74005706
42MP0002160_abnormal_reproductive_system1.72969186
43MP0002653_abnormal_ependyma_morphology1.72074853
44MP0001485_abnormal_pinna_reflex1.70447846
45MP0005390_skeleton_phenotype1.70410513
46MP0010094_abnormal_chromosome_stability1.70099881
47MP0009046_muscle_twitch1.68079959
48MP0002736_abnormal_nociception_after1.67236590
49MP0003122_maternal_imprinting1.66610120
50MP0008875_abnormal_xenobiotic_pharmacok1.66395620
51MP0002876_abnormal_thyroid_physiology1.65619439
52MP0002234_abnormal_pharynx_morphology1.61706325
53MP0001533_abnormal_skeleton_physiology1.56033365
54MP0002928_abnormal_bile_duct1.52144215
55MP0001501_abnormal_sleep_pattern1.48629113
56MP0002116_abnormal_craniofacial_bone1.48507594
57MP0001299_abnormal_eye_distance/1.48243041
58MP0000049_abnormal_middle_ear1.46752622
59MP0005389_reproductive_system_phenotype1.46612559
60MP0008057_abnormal_DNA_replication1.46024769
61MP0003795_abnormal_bone_structure1.45097247
62MP0003698_abnormal_male_reproductive1.44875896
63MP0002837_dystrophic_cardiac_calcinosis1.44552551
64MP0002272_abnormal_nervous_system1.40876062
65MP0001529_abnormal_vocalization1.37986144
66MP0001486_abnormal_startle_reflex1.35189656
67MP0004742_abnormal_vestibular_system1.33685099
68MP0003950_abnormal_plasma_membrane1.32434000
69MP0000432_abnormal_head_morphology1.30520586
70MP0001663_abnormal_digestive_system1.30414191
71MP0005174_abnormal_tail_pigmentation1.30299584
72MP0004147_increased_porphyrin_level1.30054190
73MP0001905_abnormal_dopamine_level1.29312624
74MP0009697_abnormal_copulation1.28768227
75MP0002108_abnormal_muscle_morphology1.28423538
76MP0001919_abnormal_reproductive_system1.28050394
77MP0001873_stomach_inflammation1.27465921
78MP0001929_abnormal_gametogenesis1.25852583
79MP0002557_abnormal_social/conspecific_i1.25682050
80MP0003111_abnormal_nucleus_morphology1.23635509
81MP0003755_abnormal_palate_morphology1.22857357
82MP0006072_abnormal_retinal_apoptosis1.22563367
83MP0002277_abnormal_respiratory_mucosa1.22083681
84MP0004197_abnormal_fetal_growth/weight/1.20950994
85MP0002064_seizures1.20838904
86MP0003718_maternal_effect1.18788234
87MP0003436_decreased_susceptibility_to1.16851146
88MP0005381_digestive/alimentary_phenotyp1.16793792
89MP0004019_abnormal_vitamin_homeostasis1.16648089
90MP0003935_abnormal_craniofacial_develop1.15909554
91MP0010030_abnormal_orbit_morphology1.15681586
92MP0003137_abnormal_impulse_conducting1.14849020
93MP0003283_abnormal_digestive_organ1.14000218
94MP0005551_abnormal_eye_electrophysiolog1.12592263
95MP0002067_abnormal_sensory_capabilities1.12493622
96MP0003279_aneurysm1.12281633
97MP0004133_heterotaxia1.12032356
98MP0002572_abnormal_emotion/affect_behav1.11848302
99MP0001970_abnormal_pain_threshold1.11039399
100MP0003136_yellow_coat_color1.10719733
101MP0003880_abnormal_central_pattern1.08483826
102MP0002638_abnormal_pupillary_reflex1.08273906
103MP0004145_abnormal_muscle_electrophysio1.07004804
104MP0000631_abnormal_neuroendocrine_gland1.06889650
105MP0006276_abnormal_autonomic_nervous1.06830515
106MP0002210_abnormal_sex_determination1.06265384
107MP0002733_abnormal_thermal_nociception1.06144578
108MP0003937_abnormal_limbs/digits/tail_de1.05330008
109MP0005332_abnormal_amino_acid1.04620131
110MP0005636_abnormal_mineral_homeostasis1.04553948
111MP0005253_abnormal_eye_physiology1.03721837
112MP0002139_abnormal_hepatobiliary_system1.02891681
113MP0001963_abnormal_hearing_physiology1.01378198
114MP0002114_abnormal_axial_skeleton1.01199237
115MP0002111_abnormal_tail_morphology1.00978446
116MP0002233_abnormal_nose_morphology1.00414176
117MP0001765_abnormal_ion_homeostasis1.00368927
118MP0000465_gastrointestinal_hemorrhage1.00324849
119MP0008004_abnormal_stomach_pH0.98485033
120MP0001984_abnormal_olfaction0.98038727
121MP0002734_abnormal_mechanical_nocicepti0.97594548
122MP0002229_neurodegeneration0.97270432
123MP0004808_abnormal_hematopoietic_stem0.94572247
124MP0004957_abnormal_blastocyst_morpholog0.93796260
125MP0000026_abnormal_inner_ear0.92793861
126MP0002751_abnormal_autonomic_nervous0.92363724
127MP0005076_abnormal_cell_differentiation0.90484190
128MP0005645_abnormal_hypothalamus_physiol0.88424067
129MP0000639_abnormal_adrenal_gland0.87943468
130MP0004215_abnormal_myocardial_fiber0.87460207
131MP0001440_abnormal_grooming_behavior0.87180183
132MP0004924_abnormal_behavior0.87127971
133MP0005386_behavior/neurological_phenoty0.87127971
134MP0002693_abnormal_pancreas_physiology0.86604867
135MP0003635_abnormal_synaptic_transmissio0.86287451
136MP0003786_premature_aging0.86183303
137MP0001764_abnormal_homeostasis0.85616584
138MP0000653_abnormal_sex_gland0.85313702
139MP0005671_abnormal_response_to0.84903066
140MP0003385_abnormal_body_wall0.83688799
141MP0003868_abnormal_feces_composition0.82765669
142MP0000427_abnormal_hair_cycle0.82500762
143MP0003806_abnormal_nucleotide_metabolis0.81853517
144MP0008789_abnormal_olfactory_epithelium0.80627347
145MP0000569_abnormal_digit_pigmentation0.78409692
146MP0003077_abnormal_cell_cycle0.78380700
147MP0001145_abnormal_male_reproductive0.78378523
148MP0002184_abnormal_innervation0.77674609
149MP0008058_abnormal_DNA_repair0.76718412
150MP0005195_abnormal_posterior_eye0.76547593
151MP0001944_abnormal_pancreas_morphology0.75284752
152MP0002932_abnormal_joint_morphology0.74054215
153MP0003763_abnormal_thymus_physiology0.72938120
154MP0000703_abnormal_thymus_morphology0.72367672
155MP0005379_endocrine/exocrine_gland_phen0.71165665
156MP0005409_darkened_coat_color0.70824664
157MP0000343_altered_response_to0.67033398
158MP0005220_abnormal_exocrine_pancreas0.66759058
159MP0003943_abnormal_hepatobiliary_system0.63442413
160MP0001286_abnormal_eye_development0.63354956
161MP0002938_white_spotting0.60695550
162MP0002396_abnormal_hematopoietic_system0.59315528
163MP0002735_abnormal_chemical_nociception0.59187717
164MP0001542_abnormal_bone_strength0.56745880
165MP0000462_abnormal_digestive_system0.56231900
166MP0003890_abnormal_embryonic-extraembry0.56137713
167MP0001188_hyperpigmentation0.53773885
168MP0001119_abnormal_female_reproductive0.52813914
169MP0003183_abnormal_peptide_metabolism0.50004859
170MP0010386_abnormal_urinary_bladder0.49876721
171MP0001243_abnormal_dermal_layer0.48718583
172MP0009672_abnormal_birth_weight0.48604787
173MP0008877_abnormal_DNA_methylation0.48596696
174MP0008007_abnormal_cellular_replicative0.48545149
175MP0003942_abnormal_urinary_system0.47983086
176MP0003705_abnormal_hypodermis_morpholog0.47315960
177MP0005646_abnormal_pituitary_gland0.45453855
178MP0001340_abnormal_eyelid_morphology0.45083719

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.55249174
2Irregular epiphyses (HP:0010582)9.34922050
3Vitreoretinal degeneration (HP:0000655)8.09806322
4Small epiphyses (HP:0010585)6.71586790
5Hypoplastic ischia (HP:0003175)6.36909949
6Abnormal tarsal ossification (HP:0008369)6.21812032
7Cupped ribs (HP:0000887)6.09427174
8Flat capital femoral epiphysis (HP:0003370)5.90649119
9Delayed epiphyseal ossification (HP:0002663)5.63424071
10Abnormality of the ischium (HP:0003174)5.57502222
11Metaphyseal cupping (HP:0003021)5.36830245
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.35576238
13* Genu varum (HP:0002970)5.23263366
14Metaphyseal dysplasia (HP:0100255)5.02284615
15Flat acetabular roof (HP:0003180)5.01270543
16* Abnormality of femoral epiphyses (HP:0006499)4.88955908
17* Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.88955908
18Mild short stature (HP:0003502)4.79771666
19Abnormal foot bone ossification (HP:0010675)4.65384555
20* Abnormality of the vertebral endplates (HP:0005106)4.62140090
21* Abnormality of the epiphysis of the femoral head (HP:0010574)4.43853486
22Irregular vertebral endplates (HP:0003301)4.43579234
23Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.41451993
24Absent epiphyses (HP:0010577)4.41451993
25Hypothermia (HP:0002045)4.36648490
26Arthropathy (HP:0003040)4.33467353
27Short femoral neck (HP:0100864)4.12098121
28Abnormality of midbrain morphology (HP:0002418)4.08789813
29Molar tooth sign on MRI (HP:0002419)4.08789813
30* Abnormality of the femoral head (HP:0003368)4.04616975
31Pancreatic cysts (HP:0001737)3.81902672
32Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.75502841
33Pancreatic fibrosis (HP:0100732)3.73662681
34Abnormal drinking behavior (HP:0030082)3.69492806
35Polydipsia (HP:0001959)3.69492806
36Metaphyseal irregularity (HP:0003025)3.66906185
37Dynein arm defect of respiratory motile cilia (HP:0012255)3.60398743
38Absent/shortened dynein arms (HP:0200106)3.60398743
39Neonatal short-limb short stature (HP:0008921)3.53291885
40* Osteoarthritis (HP:0002758)3.52956305
41Nephronophthisis (HP:0000090)3.43171562
42* Flattened epiphyses (HP:0003071)3.41518157
43True hermaphroditism (HP:0010459)3.30874764
44Hypomagnesemia (HP:0002917)3.29332133
45Carpal bone hypoplasia (HP:0001498)3.28205937
46Abnormality of carpal bone ossification (HP:0006257)3.23678790
47Chronic hepatic failure (HP:0100626)3.20527695
48* Coxa vara (HP:0002812)3.18089450
49Congenital stationary night blindness (HP:0007642)3.10778834
50Thoracolumbar scoliosis (HP:0002944)3.09701280
51Protuberant abdomen (HP:0001538)3.05459094
52Limited elbow extension (HP:0001377)3.04747776
53Absent frontal sinuses (HP:0002688)3.02110577
54Medial flaring of the eyebrow (HP:0010747)2.96543513
55Abnormality of the pubic bones (HP:0003172)2.96511720
56Abnormal respiratory motile cilium morphology (HP:0005938)2.95756491
57Abnormal respiratory epithelium morphology (HP:0012253)2.95756491
58* Platyspondyly (HP:0000926)2.94226304
59Barrel-shaped chest (HP:0001552)2.93342544
60* Waddling gait (HP:0002515)2.90551023
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.86440577
62Abnormality of the proximal phalanges of the hand (HP:0009834)2.85171501
63Abnormality of the renal medulla (HP:0100957)2.85126931
64Tetany (HP:0001281)2.82735814
65Aplasia/hypoplasia of the femur (HP:0005613)2.82344921
66Polyuria (HP:0000103)2.81717028
67* Enlarged epiphyses (HP:0010580)2.80417017
68Abnormality of the renal cortex (HP:0011035)2.77958463
69Beaking of vertebral bodies (HP:0004568)2.77374375
70Limited hip movement (HP:0008800)2.77373568
71Ovoid vertebral bodies (HP:0003300)2.70440716
72Increased hepatocellular lipid droplets (HP:0006565)2.69358641
73Stillbirth (HP:0003826)2.68730330
74Abnormal ciliary motility (HP:0012262)2.67794987
75Abnormal hand bone ossification (HP:0010660)2.67606663
76Long clavicles (HP:0000890)2.67411186
77Type II lissencephaly (HP:0007260)2.66614650
78Abnormal vertebral ossification (HP:0100569)2.64800004
79Renal Fanconi syndrome (HP:0001994)2.61827822
80Lipid accumulation in hepatocytes (HP:0006561)2.57898258
81Hip contracture (HP:0003273)2.57791574
82Abnormal rod and cone electroretinograms (HP:0008323)2.57313222
83Abnormal ossification of hand bones (HP:0005921)2.56435011
84Attenuation of retinal blood vessels (HP:0007843)2.55390464
85Congenital, generalized hypertrichosis (HP:0004540)2.55388113
86Duplicated collecting system (HP:0000081)2.55029070
87Chronic sinusitis (HP:0011109)2.53739900
88Abolished electroretinogram (ERG) (HP:0000550)2.53011473
89Exostoses (HP:0100777)2.52140115
90Relative macrocephaly (HP:0004482)2.51768000
91Abnormality of the renal collecting system (HP:0004742)2.51291904
92Gait imbalance (HP:0002141)2.50849466
93Abnormality of incisor morphology (HP:0011063)2.50387492
94Lumbar hyperlordosis (HP:0002938)2.50148389
95Mesomelia (HP:0003027)2.49723244
96Abnormality of magnesium homeostasis (HP:0004921)2.49411946
97Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.42966892
98Spinal cord compression (HP:0002176)2.41125703
99Bony spicule pigmentary retinopathy (HP:0007737)2.41118011
100Renal cortical cysts (HP:0000803)2.40612422
101Mitochondrial inheritance (HP:0001427)2.39039396
102Thin ribs (HP:0000883)2.38627323
103Vertebral clefting (HP:0008428)2.37888711
104Large for gestational age (HP:0001520)2.37211137
105Inability to walk (HP:0002540)2.34570618
106Hypoplasia of the odontoid process (HP:0003311)2.33890024
107Abnormal urine output (HP:0012590)2.33539522
108Congenital primary aphakia (HP:0007707)2.32641243
109Abnormal respiratory motile cilium physiology (HP:0012261)2.31952661
110Short middle phalanx of finger (HP:0005819)2.31558651
111Abnormality of the lumbar spine (HP:0100712)2.30655699
112Broad phalanx (HP:0006009)2.29241504
113Cervical subluxation (HP:0003308)2.27937639
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27695348
115Hyperventilation (HP:0002883)2.26450580
116Acute necrotizing encephalopathy (HP:0006965)2.25071283
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.23590452
118Abnormality of the vitreous humor (HP:0004327)2.22162508
119Micromelia (HP:0002983)2.21912541
120Chronic otitis media (HP:0000389)2.21815895
121Increased CSF lactate (HP:0002490)2.20470457
122Progressive inability to walk (HP:0002505)2.20398666
123Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18172189
124Exertional dyspnea (HP:0002875)2.16125494
125Decreased circulating renin level (HP:0003351)2.15543224
126Aplasia/Hypoplasia of the uvula (HP:0010293)2.14815685
127Hypoplastic pelvis (HP:0008839)2.14321989
128Broad long bones (HP:0005622)2.11082351
129Nephrogenic diabetes insipidus (HP:0009806)2.10231518
130Abnormality of renal resorption (HP:0011038)2.09804769
131Abnormality of renal excretion (HP:0011036)2.09683854
132Sclerocornea (HP:0000647)2.08889878
133Abnormality of the 2nd finger (HP:0004100)2.08845973
134Cystic liver disease (HP:0006706)2.08616016
135Glossoptosis (HP:0000162)2.08370127
136Hypoplastic ilia (HP:0000946)2.06109556
137Keratoconus (HP:0000563)2.04625481
138Increased corneal curvature (HP:0100692)2.04625481
139Acute encephalopathy (HP:0006846)2.02735732
140Abnormality of the acetabulum (HP:0003170)2.02148162
141Absent thumb (HP:0009777)2.01929475
142Thyroid-stimulating hormone excess (HP:0002925)2.01404633
143Nasal polyposis (HP:0100582)2.00546171
144Progressive macrocephaly (HP:0004481)2.00367026
145Tachypnea (HP:0002789)1.99257836
146Chorioretinal atrophy (HP:0000533)1.99169785
147Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.99055652
148Supernumerary spleens (HP:0009799)1.98275172
149Flared metaphyses (HP:0003015)1.98033853
150Fibular hypoplasia (HP:0003038)1.97802125
151Febrile seizures (HP:0002373)1.97384930
152Broad-based gait (HP:0002136)1.94514020
153Abnormality of urine glucose concentration (HP:0011016)1.94079961
154Glycosuria (HP:0003076)1.94079961
155Tubular atrophy (HP:0000092)1.94059326
156Decreased central vision (HP:0007663)1.93219984
157Postaxial foot polydactyly (HP:0001830)1.92152446
1583-Methylglutaconic aciduria (HP:0003535)1.91620968
159Hepatocellular necrosis (HP:0001404)1.91038055
160Gaze-evoked nystagmus (HP:0000640)1.90655543
161Broad thumb (HP:0011304)1.90577713
162Broad phalanges of the hand (HP:0009768)1.90196591
163Disproportionate short-trunk short stature (HP:0003521)1.89767748
164Abnormality of the odontoid process (HP:0003310)1.89530135
165Abnormality of DNA repair (HP:0003254)1.89086210
166Genital tract atresia (HP:0001827)1.87805079
167Broad finger (HP:0001500)1.87178654
168Abnormal mitochondria in muscle tissue (HP:0008316)1.86995019
169Hepatic necrosis (HP:0002605)1.85916628
170Abnormality of the intervertebral disk (HP:0005108)1.84152328
171Hypoalbuminemia (HP:0003073)1.83454923
172Abnormal albumin level (HP:0012116)1.83454923
173Bulbous nose (HP:0000414)1.83343806
174Pendular nystagmus (HP:0012043)1.83092037
175Abnormality of the ileum (HP:0001549)1.82758638
176Limb dystonia (HP:0002451)1.82678656
177Bronchiectasis (HP:0002110)1.82662925
178Ketoacidosis (HP:0001993)1.82662046
179Meckel diverticulum (HP:0002245)1.82045683
180Aplasia/Hypoplasia of the tongue (HP:0010295)1.80370734
181Genu valgum (HP:0002857)1.78843554
182Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77593447
183Vertebral hypoplasia (HP:0008417)1.77593447
184Astigmatism (HP:0000483)1.76893666
185Congenital hepatic fibrosis (HP:0002612)1.76819079
186Mixed hearing impairment (HP:0000410)1.76503097
187Abnormality of the frontal sinuses (HP:0002687)1.75995744
188Vaginal atresia (HP:0000148)1.75569258
189Ketosis (HP:0001946)1.75455694
190Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75392863
191Abnormality of the pons (HP:0007361)1.74625484
192Short ribs (HP:0000773)1.74051061
193Anencephaly (HP:0002323)1.73543342
194Hepatoblastoma (HP:0002884)1.73131957
195Male pseudohermaphroditism (HP:0000037)1.72895889
196Furrowed tongue (HP:0000221)1.72534645
197Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.70636527
198Optic disc pallor (HP:0000543)1.70149336
199Radial bowing (HP:0002986)1.69994720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L4.83548514
2MAP3K34.64738459
3NME14.49725726
4DDR24.12898534
5FRK3.75119634
6TLK13.68327527
7MAP4K23.31996164
8LATS13.30954649
9STK242.98634759
10INSRR2.81070331
11MST42.64488809
12MKNK22.41125487
13CDC72.30915838
14ADRBK22.28112926
15MKNK12.22098387
16PLK22.20876958
17TGFBR12.12924901
18ERBB32.12222940
19PASK2.08957076
20PNCK1.99736556
21SRPK11.98692909
22PLK31.91772357
23ZAK1.82020669
24PRKD31.81637081
25STK31.72934568
26MELK1.68346393
27CAMKK21.65189871
28BCKDK1.61629198
29CASK1.60430542
30PRKG21.58551145
31DYRK1A1.54146886
32MAPK71.51572567
33BRSK21.50852426
34WNK31.48044440
35PINK11.47206999
36NUAK11.42227792
37DAPK21.34862842
38MAPK151.28887842
39BMPR1B1.25701922
40PAK31.22842288
41EIF2AK31.22695409
42STK391.22467241
43VRK11.20417113
44PHKG21.20387098
45PHKG11.20387098
46MARK11.16910187
47MAP3K41.16685033
48CAMKK11.16625345
49PKN21.15785138
50OXSR11.09859493
51BRD41.09604473
52TRIM281.09389245
53SGK21.08955854
54MUSK0.99288137
55MAPK40.98522004
56TXK0.97587248
57MAPK120.95058930
58SGK30.91634414
59TIE10.88798104
60TAOK30.84977856
61PRKCG0.83370792
62TNIK0.83300101
63BUB10.79112798
64YES10.79028182
65ACVR1B0.78007711
66PRKCE0.77305013
67BCR0.76098800
68ADRBK10.75550814
69CDK120.75171574
70NTRK20.75141897
71GRK70.74322413
72BMPR20.74224139
73STK160.73938679
74MAP3K130.73143876
75PIM20.73051950
76DYRK20.72658589
77CHEK10.72056719
78WEE10.69701487
79TTK0.68673184
80IKBKB0.68180018
81MAP2K60.65729617
82NLK0.65377886
83MAP3K120.64652288
84AURKB0.63209886
85PKN10.62058397
86GSK3A0.60463651
87CAMK40.59721653
88TRPM70.59397392
89MAPKAPK50.59361077
90PIM10.58729859
91BRSK10.58561865
92PLK10.58452029
93ATR0.58200696
94NTRK30.57781582
95PIK3CG0.56394794
96SIK20.55160969
97CSNK1G20.54809826
98SGK2230.54527386
99SGK4940.54527386
100FGFR30.54503695
101PRKCQ0.54273537
102TEC0.53718686
103RPS6KB10.52917585
104CAMK2A0.50549992
105MAP2K70.50278411
106CDK40.49394897
107EIF2AK20.48755329
108PIK3CA0.48241587
109ATM0.47454820
110CDK10.47357902
111PRKCI0.47216241
112MAPK140.46336174
113LATS20.46252394
114ROCK10.46062759
115CSNK1G30.45038433
116LIMK10.44875791
117PRKG10.44421799
118CDK30.43679746
119CDK20.43412130
120IGF1R0.42896362
121MARK20.42135966
122NEK60.40934411
123FGFR20.40262968
124MAPKAPK30.40148828
125NEK10.40057539
126TNK20.40009794
127FGFR10.39845477
128MAP3K90.39833261
129SIK10.39814333
130CSNK1A1L0.39668068
131MAPK30.38913707
132MAPK100.38622978
133STK100.38102799
134NEK20.37849839
135PTK2B0.37339283
136PRKACA0.37241854
137SGK10.34064261
138EPHA40.33929822
139MAPK130.33269288
140MAPK10.33223872
141RPS6KA50.32851726
142PRKCA0.31226765
143KIT0.31194812
144PRKCH0.30492240
145AKT10.29996886
146CAMK10.29971707
147CSNK1G10.29812076
148CSNK1A10.29661065
149PRKAA20.29139993
150RPS6KB20.28263237
151ITK0.28061891
152CSNK1D0.27992519
153PLK40.27865459
154SYK0.27725012
155PTK60.27662520
156PRKCZ0.27394485
157IKBKE0.26698483
158MAP4K10.26572194
159OBSCN0.26471218
160GRK10.26458349
161SIK30.25849550
162PRKAA10.25753720
163VRK20.25694471
164CDK80.25572882
165WNK40.25284664
166ABL10.25136206
167AKT30.25092891
168PRKDC0.24990483
169GSK3B0.24677578

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005326.78468283
2Protein digestion and absorption_Homo sapiens_hsa049744.36198797
3ECM-receptor interaction_Homo sapiens_hsa045124.27922814
4Phototransduction_Homo sapiens_hsa047443.39001519
5Non-homologous end-joining_Homo sapiens_hsa034503.34481183
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.93135282
7Oxidative phosphorylation_Homo sapiens_hsa001902.75743986
8Linoleic acid metabolism_Homo sapiens_hsa005912.46469160
9Butanoate metabolism_Homo sapiens_hsa006502.44563066
10One carbon pool by folate_Homo sapiens_hsa006702.33287162
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32090740
12Nitrogen metabolism_Homo sapiens_hsa009102.10565676
13Cell cycle_Homo sapiens_hsa041102.09030713
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08503472
15Parkinsons disease_Homo sapiens_hsa050122.00863507
16Selenocompound metabolism_Homo sapiens_hsa004501.98680615
17Sulfur metabolism_Homo sapiens_hsa009201.95366478
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92960490
19RNA transport_Homo sapiens_hsa030131.91232379
20Nicotine addiction_Homo sapiens_hsa050331.90233953
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76092928
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74292024
23RNA degradation_Homo sapiens_hsa030181.71567932
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69175052
25Ether lipid metabolism_Homo sapiens_hsa005651.68589808
26Collecting duct acid secretion_Homo sapiens_hsa049661.65589736
27Tryptophan metabolism_Homo sapiens_hsa003801.64450850
28Lysine degradation_Homo sapiens_hsa003101.63078148
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61846717
30Steroid biosynthesis_Homo sapiens_hsa001001.57801851
31TGF-beta signaling pathway_Homo sapiens_hsa043501.57346672
32Cardiac muscle contraction_Homo sapiens_hsa042601.56686074
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55989019
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52421846
35Primary immunodeficiency_Homo sapiens_hsa053401.48065163
36DNA replication_Homo sapiens_hsa030301.47759680
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47463197
38Huntingtons disease_Homo sapiens_hsa050161.46827836
39Mismatch repair_Homo sapiens_hsa034301.44550450
40RNA polymerase_Homo sapiens_hsa030201.42783067
41Base excision repair_Homo sapiens_hsa034101.41877448
42PI3K-Akt signaling pathway_Homo sapiens_hsa041511.41014554
43Propanoate metabolism_Homo sapiens_hsa006401.38126029
44Taste transduction_Homo sapiens_hsa047421.33091619
45Alzheimers disease_Homo sapiens_hsa050101.29931826
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27797254
47Homologous recombination_Homo sapiens_hsa034401.26221445
48Proteasome_Homo sapiens_hsa030501.24750247
49Salivary secretion_Homo sapiens_hsa049701.22442812
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19987844
51Spliceosome_Homo sapiens_hsa030401.18495203
52Focal adhesion_Homo sapiens_hsa045101.17575060
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16937716
54Insulin secretion_Homo sapiens_hsa049111.16878110
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15565710
56Circadian rhythm_Homo sapiens_hsa047101.14690377
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13218871
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12335976
59Olfactory transduction_Homo sapiens_hsa047401.11710706
60Starch and sucrose metabolism_Homo sapiens_hsa005001.06687413
61Ovarian steroidogenesis_Homo sapiens_hsa049131.04915462
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04491062
63Ribosome_Homo sapiens_hsa030101.03586016
64Malaria_Homo sapiens_hsa051441.01935838
65Sphingolipid metabolism_Homo sapiens_hsa006001.01211483
66Basal transcription factors_Homo sapiens_hsa030221.00277904
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99755487
68Morphine addiction_Homo sapiens_hsa050320.98003041
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.97208457
70mRNA surveillance pathway_Homo sapiens_hsa030150.95445469
71Pyrimidine metabolism_Homo sapiens_hsa002400.94490289
72Arachidonic acid metabolism_Homo sapiens_hsa005900.94422690
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94176383
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.93825133
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92165364
76Chemical carcinogenesis_Homo sapiens_hsa052040.92055535
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91385715
78Purine metabolism_Homo sapiens_hsa002300.90356524
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.88886931
80Peroxisome_Homo sapiens_hsa041460.86644098
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84878670
82Protein export_Homo sapiens_hsa030600.84000536
83Type I diabetes mellitus_Homo sapiens_hsa049400.83465239
84Amphetamine addiction_Homo sapiens_hsa050310.82781160
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82441294
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81992734
87Thyroid cancer_Homo sapiens_hsa052160.81795754
88Colorectal cancer_Homo sapiens_hsa052100.79051577
89N-Glycan biosynthesis_Homo sapiens_hsa005100.77144405
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76421216
91Nucleotide excision repair_Homo sapiens_hsa034200.75833771
92T cell receptor signaling pathway_Homo sapiens_hsa046600.75480231
93Circadian entrainment_Homo sapiens_hsa047130.74584262
94MicroRNAs in cancer_Homo sapiens_hsa052060.70821752
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70772746
96ABC transporters_Homo sapiens_hsa020100.70588596
97Folate biosynthesis_Homo sapiens_hsa007900.70161025
98mTOR signaling pathway_Homo sapiens_hsa041500.69858280
99HTLV-I infection_Homo sapiens_hsa051660.68850279
100Serotonergic synapse_Homo sapiens_hsa047260.68074950
101Hippo signaling pathway_Homo sapiens_hsa043900.68005865
102Arginine and proline metabolism_Homo sapiens_hsa003300.67278847
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67131581
104Regulation of autophagy_Homo sapiens_hsa041400.66350308
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65554667
106Fatty acid biosynthesis_Homo sapiens_hsa000610.65130715
107Basal cell carcinoma_Homo sapiens_hsa052170.64705478
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64365807
109Graft-versus-host disease_Homo sapiens_hsa053320.64262471
110Metabolic pathways_Homo sapiens_hsa011000.63815946
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62235070
112Fatty acid degradation_Homo sapiens_hsa000710.61857462
113Glutamatergic synapse_Homo sapiens_hsa047240.61681525
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61146324
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59909659
116GABAergic synapse_Homo sapiens_hsa047270.59819599
117Hepatitis B_Homo sapiens_hsa051610.59184414
118Hedgehog signaling pathway_Homo sapiens_hsa043400.58379081
119Mineral absorption_Homo sapiens_hsa049780.58096361
120Synaptic vesicle cycle_Homo sapiens_hsa047210.57594798
121Allograft rejection_Homo sapiens_hsa053300.56553545
122beta-Alanine metabolism_Homo sapiens_hsa004100.55617031
123FoxO signaling pathway_Homo sapiens_hsa040680.55537505
124HIF-1 signaling pathway_Homo sapiens_hsa040660.55096740
125Fat digestion and absorption_Homo sapiens_hsa049750.55051234
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54659457
127Glycerolipid metabolism_Homo sapiens_hsa005610.53718293
128Vitamin B6 metabolism_Homo sapiens_hsa007500.53647941
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53517994
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53012213
131Hematopoietic cell lineage_Homo sapiens_hsa046400.50189044
132Autoimmune thyroid disease_Homo sapiens_hsa053200.50098014
133Dopaminergic synapse_Homo sapiens_hsa047280.49861473
134Calcium signaling pathway_Homo sapiens_hsa040200.49309190
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47722264
136Adherens junction_Homo sapiens_hsa045200.46387605
137Asthma_Homo sapiens_hsa053100.45920303
138Phagosome_Homo sapiens_hsa041450.45852079
139Rheumatoid arthritis_Homo sapiens_hsa053230.44664516
140Proteoglycans in cancer_Homo sapiens_hsa052050.44532759
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39678195
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38951521
143Prostate cancer_Homo sapiens_hsa052150.38779846
144Fatty acid metabolism_Homo sapiens_hsa012120.38364024
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36162427
146Histidine metabolism_Homo sapiens_hsa003400.36075211
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34954934
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.33959327
149Legionellosis_Homo sapiens_hsa051340.33770538
150Fanconi anemia pathway_Homo sapiens_hsa034600.32620660
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32255309
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31985158
153Oxytocin signaling pathway_Homo sapiens_hsa049210.30705605
154Retinol metabolism_Homo sapiens_hsa008300.30470189
155Viral carcinogenesis_Homo sapiens_hsa052030.29973669
156Oocyte meiosis_Homo sapiens_hsa041140.29387010
157Pancreatic cancer_Homo sapiens_hsa052120.29193138
158Thyroid hormone synthesis_Homo sapiens_hsa049180.28571824
159B cell receptor signaling pathway_Homo sapiens_hsa046620.26335798
160Wnt signaling pathway_Homo sapiens_hsa043100.24786843
161Galactose metabolism_Homo sapiens_hsa000520.22846140
162Glucagon signaling pathway_Homo sapiens_hsa049220.22262513
163Cholinergic synapse_Homo sapiens_hsa047250.21928345
164Biosynthesis of amino acids_Homo sapiens_hsa012300.19356584
165Epstein-Barr virus infection_Homo sapiens_hsa051690.18890581
166Drug metabolism - other enzymes_Homo sapiens_hsa009830.18238816
167Small cell lung cancer_Homo sapiens_hsa052220.17398973
168Cocaine addiction_Homo sapiens_hsa050300.16804108
169Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16273488
170Caffeine metabolism_Homo sapiens_hsa002320.15948573
171p53 signaling pathway_Homo sapiens_hsa041150.15405108
172AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15108140
173Long-term depression_Homo sapiens_hsa047300.14966118

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »