WIZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.25732422
2regulation of posttranscriptional gene silencing (GO:0060147)5.25732422
3regulation of gene silencing by miRNA (GO:0060964)5.25732422
4planar cell polarity pathway involved in neural tube closure (GO:0090179)5.05969182
5pre-miRNA processing (GO:0031054)4.88723550
6nuclear pore organization (GO:0006999)4.74666591
7nuclear pore complex assembly (GO:0051292)4.63503195
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.62697983
9heterochromatin organization (GO:0070828)4.40390664
10paraxial mesoderm development (GO:0048339)4.33047925
11DNA unwinding involved in DNA replication (GO:0006268)4.22591265
12adherens junction assembly (GO:0034333)4.20352335
13DNA replication-dependent nucleosome organization (GO:0034723)4.18843182
14DNA replication-dependent nucleosome assembly (GO:0006335)4.18843182
15regulation of NFAT protein import into nucleus (GO:0051532)4.15962971
16protein localization to kinetochore (GO:0034501)4.09718201
17regulation of telomere maintenance via telomerase (GO:0032210)3.96053253
18folic acid-containing compound biosynthetic process (GO:0009396)3.89143525
19mitotic nuclear envelope disassembly (GO:0007077)3.84878655
20regulation of early endosome to late endosome transport (GO:2000641)3.79761974
21focal adhesion assembly (GO:0048041)3.78133916
22cell-substrate adherens junction assembly (GO:0007045)3.78133916
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.77898229
24maturation of SSU-rRNA (GO:0030490)3.77255707
25negative regulation of cell size (GO:0045792)3.75360459
26kinetochore organization (GO:0051383)3.72397508
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68356260
28kinetochore assembly (GO:0051382)3.63193949
29cytoskeletal anchoring at plasma membrane (GO:0007016)3.61313423
30mitotic metaphase plate congression (GO:0007080)3.61049990
31protein localization to endosome (GO:0036010)3.59576952
32membrane disassembly (GO:0030397)3.59524092
33nuclear envelope disassembly (GO:0051081)3.59524092
34apoptotic process involved in morphogenesis (GO:0060561)3.58227699
35negative regulation of histone methylation (GO:0031061)3.53534760
36cell-substrate junction assembly (GO:0007044)3.53220303
37protein retention in ER lumen (GO:0006621)3.51148174
38pore complex assembly (GO:0046931)3.49910237
39protein localization to chromosome, centromeric region (GO:0071459)3.49603107
40viral transcription (GO:0019083)3.49599724
41DNA duplex unwinding (GO:0032508)3.49407998
42regulation of histone H3-K9 methylation (GO:0051570)3.49248948
43negative regulation of erythrocyte differentiation (GO:0045647)3.47990659
44DNA geometric change (GO:0032392)3.47094578
45ribosomal small subunit biogenesis (GO:0042274)3.45837606
46histone H4-K12 acetylation (GO:0043983)3.44688849
47DNA replication initiation (GO:0006270)3.43757761
48DNA strand elongation involved in DNA replication (GO:0006271)3.42291687
49semaphorin-plexin signaling pathway (GO:0071526)3.41494952
50peptidyl-arginine omega-N-methylation (GO:0035247)3.40891284
51negative regulation of mRNA processing (GO:0050686)3.39679027
52IMP biosynthetic process (GO:0006188)3.39274048
53translational termination (GO:0006415)3.37965912
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37715757
55diaphragm development (GO:0060539)3.37082484
56regulation of gene silencing (GO:0060968)3.35297607
57ribosomal large subunit biogenesis (GO:0042273)3.34316899
58basement membrane organization (GO:0071711)3.33352240
59skeletal muscle organ development (GO:0060538)3.33161487
60mitotic sister chromatid segregation (GO:0000070)3.32090623
61negative regulation of RNA splicing (GO:0033119)3.31847979
62formation of translation preinitiation complex (GO:0001731)3.31777854
63chromatin assembly (GO:0031497)3.27651421
64Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.25866042
65activation of MAPKKK activity (GO:0000185)3.24814205
66chromatin remodeling at centromere (GO:0031055)3.23745653
67histone arginine methylation (GO:0034969)3.23196726
68DNA strand elongation (GO:0022616)3.23142637
69establishment of apical/basal cell polarity (GO:0035089)3.23043714
70histone H4-K8 acetylation (GO:0043982)3.23017716
71histone H4-K5 acetylation (GO:0043981)3.23017716
72regulation of translational fidelity (GO:0006450)3.22108081
73DNA replication checkpoint (GO:0000076)3.21720519
74spliceosomal tri-snRNP complex assembly (GO:0000244)3.21417546
75dosage compensation (GO:0007549)3.20643444
76chromatin assembly or disassembly (GO:0006333)3.18722273
77sister chromatid segregation (GO:0000819)3.17099714
78dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.17051293
79metaphase plate congression (GO:0051310)3.16879228
80positive regulation of SMAD protein import into nucleus (GO:0060391)3.16849139
81regulation of helicase activity (GO:0051095)3.15337912
82negative regulation of mRNA metabolic process (GO:1903312)3.15063436
83ribonucleoprotein complex biogenesis (GO:0022613)3.14244677
84positive regulation of blood vessel endothelial cell migration (GO:0043536)3.13231310
85translational initiation (GO:0006413)3.13085007
86DNA replication-independent nucleosome organization (GO:0034724)3.12890594
87DNA replication-independent nucleosome assembly (GO:0006336)3.12890594
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12839539
89telomere maintenance via semi-conservative replication (GO:0032201)3.11025154
90Golgi transport vesicle coating (GO:0048200)3.10506837
91COPI coating of Golgi vesicle (GO:0048205)3.10506837
92convergent extension (GO:0060026)3.07892825
93regulation of establishment of planar polarity (GO:0090175)3.07357622
94atrioventricular valve morphogenesis (GO:0003181)3.05277637
95activation of Rac GTPase activity (GO:0032863)3.04890735
96cell-cell junction maintenance (GO:0045217)3.04695017
97ribosome biogenesis (GO:0042254)3.04507358
983-UTR-mediated mRNA stabilization (GO:0070935)3.03708189
99hemidesmosome assembly (GO:0031581)3.03137060
100nucleobase biosynthetic process (GO:0046112)3.02860305
101translational elongation (GO:0006414)3.02036328
102maternal placenta development (GO:0001893)3.01536961
103regulation of glucose import in response to insulin stimulus (GO:2001273)3.01251163
104somatic hypermutation of immunoglobulin genes (GO:0016446)3.00354540
105somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00354540
106negative regulation of gene silencing (GO:0060969)2.99860960
107CENP-A containing nucleosome assembly (GO:0034080)2.99765323
108negative regulation of fatty acid transport (GO:2000192)2.99623259
109RNA splicing, via transesterification reactions (GO:0000375)2.99506853
110termination of RNA polymerase II transcription (GO:0006369)2.99318236
111mRNA splicing, via spliceosome (GO:0000398)2.98153626
112RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.98153626
113cellular protein complex localization (GO:0034629)2.97498010
114spliceosomal complex assembly (GO:0000245)2.96152007
115stress fiber assembly (GO:0043149)2.94674876
116positive regulation of chromosome segregation (GO:0051984)2.92384445
117regulation of mitotic spindle organization (GO:0060236)2.92219694
118mRNA stabilization (GO:0048255)2.91977361
119RNA stabilization (GO:0043489)2.91977361
120ATP-dependent chromatin remodeling (GO:0043044)2.91736078
121epithelial cell-cell adhesion (GO:0090136)2.90693853
122peptidyl-arginine methylation (GO:0018216)2.89655541
123peptidyl-arginine N-methylation (GO:0035246)2.89655541
124cochlea morphogenesis (GO:0090103)2.88858219
125intracellular estrogen receptor signaling pathway (GO:0030520)2.88415560
126vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88017058
127establishment or maintenance of monopolar cell polarity (GO:0061339)2.87987604
128establishment of monopolar cell polarity (GO:0061162)2.87987604
129regulation of centriole replication (GO:0046599)2.84755227
130protein localization to chromosome (GO:0034502)2.84519655
131spliceosomal snRNP assembly (GO:0000387)2.84081756
132regulation of sister chromatid cohesion (GO:0007063)2.83691301
133anterior/posterior axis specification, embryo (GO:0008595)2.82399447
134camera-type eye morphogenesis (GO:0048593)2.82120304
135ribosomal small subunit assembly (GO:0000028)2.80271030
136negative regulation of chromosome segregation (GO:0051985)2.80239513
137polarized epithelial cell differentiation (GO:0030859)2.79529679
138telomere maintenance via telomere lengthening (GO:0010833)2.79523723
139mitotic recombination (GO:0006312)2.79457453
140regulation of hippo signaling (GO:0035330)2.78830832
141trophectodermal cell differentiation (GO:0001829)2.77309050
142IMP metabolic process (GO:0046040)2.76923826
143eye morphogenesis (GO:0048592)2.72910170
144protein targeting to plasma membrane (GO:0072661)2.68688836
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67172249
146lymph vessel development (GO:0001945)2.66745045
147insulin-like growth factor receptor signaling pathway (GO:0048009)2.65077453
148positive regulation of receptor recycling (GO:0001921)2.64945126
149cell migration involved in heart development (GO:0060973)2.63767913
150skin morphogenesis (GO:0043589)2.63019820
151apoptotic process involved in development (GO:1902742)2.60466632
152negative regulation of catenin import into nucleus (GO:0035414)2.59217056
153endothelial cell chemotaxis (GO:0035767)2.58312632
154vascular endothelial growth factor signaling pathway (GO:0038084)2.56472709
155embryonic eye morphogenesis (GO:0048048)2.56323151
156neural tube development (GO:0021915)2.55713349
157cell migration in hindbrain (GO:0021535)2.55059894
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52641323
159regulation of fatty acid beta-oxidation (GO:0031998)2.51839023
160regulation of extracellular matrix disassembly (GO:0010715)2.51784042
161desmosome organization (GO:0002934)2.50114159
162bone trabecula formation (GO:0060346)2.48086097
163endocytic recycling (GO:0032456)2.45982783
164cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.42014355
165modulation by virus of host morphology or physiology (GO:0019048)2.41522579
166response to laminar fluid shear stress (GO:0034616)2.41188165
167blood vessel endothelial cell migration (GO:0043534)2.40692521
168activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.39500792
169non-canonical Wnt signaling pathway (GO:0035567)2.39193252
170positive regulation of histone deacetylation (GO:0031065)2.37659287
171protein localization to microtubule (GO:0035372)2.37594795
172endodermal cell differentiation (GO:0035987)2.37547254
173* protein heterotrimerization (GO:0070208)2.36023021
174mannose metabolic process (GO:0006013)2.35060868
175G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.30683448
176positive regulation of protein export from nucleus (GO:0046827)2.30558797
177protein complex localization (GO:0031503)2.29774512
178regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29257984
179positive regulation of myotube differentiation (GO:0010831)2.28658110
180positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.28589759
181positive regulation of nuclease activity (GO:0032075)2.27972896
182proline biosynthetic process (GO:0006561)2.27332199
183mammary gland epithelial cell differentiation (GO:0060644)2.27082906
184negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.26501582
185outflow tract septum morphogenesis (GO:0003148)2.25297077
186barbed-end actin filament capping (GO:0051016)2.25075294
187regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.24756478
188positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.23750858
189regulation of apoptotic process involved in morphogenesis (GO:1902337)2.23386945
190glucocorticoid receptor signaling pathway (GO:0042921)2.22567878
191adherens junction organization (GO:0034332)2.22548131
192protein-DNA complex disassembly (GO:0032986)2.21529820
193nucleosome disassembly (GO:0006337)2.21529820
194synaptic vesicle docking involved in exocytosis (GO:0016081)2.20544128
195actin filament bundle organization (GO:0061572)2.19071612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.67238409
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.59758517
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02267261
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61243617
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.29474583
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97540136
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.89009903
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.89009903
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.89009903
10* LXR_22292898_ChIP-Seq_THP-1_Human2.84483725
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72053677
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.71294903
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65647698
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.63383294
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61065034
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58871060
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51827522
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.47655608
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35763401
20KDM2B_26808549_Chip-Seq_K562_Human2.32242625
21RACK7_27058665_Chip-Seq_MCF-7_Human2.27102239
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.27084074
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26470737
24KDM2B_26808549_Chip-Seq_DND41_Human2.25215381
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24865408
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22970341
27* XRN2_22483619_ChIP-Seq_HELA_Human2.18018935
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.09413732
29TCF7_22412390_ChIP-Seq_EML_Mouse2.06618744
30MYC_22102868_ChIP-Seq_BL_Human2.05039924
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04302693
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.97561170
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96370422
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.94439718
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93218640
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.92268880
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89631660
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88772113
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.88287119
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86663352
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86365392
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85310246
43* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.81803015
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80997085
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80523527
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.79650994
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78505195
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.77793174
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77641176
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.75053934
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.70654298
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69498901
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69475958
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.69410339
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.68182797
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.67924483
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.66977816
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.66426866
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65058236
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64426019
61AR_21909140_ChIP-Seq_LNCAP_Human1.63416339
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62437002
63TTF2_22483619_ChIP-Seq_HELA_Human1.61269494
64* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60724414
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59398760
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56568046
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56488456
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56272938
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56231873
70P68_20966046_ChIP-Seq_HELA_Human1.55268555
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.54016199
72SMC4_20622854_ChIP-Seq_HELA_Human1.53849063
73CIITA_25753668_ChIP-Seq_RAJI_Human1.52199102
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52113491
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48586808
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47433733
77CREB1_26743006_Chip-Seq_LNCaP_Human1.47327029
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47204003
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44983836
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44206515
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42274602
82POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39906325
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39391701
84CLOCK_20551151_ChIP-Seq_293T_Human1.38947742
85TP53_22127205_ChIP-Seq_IMR90_Human1.38395347
86* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37529832
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35888177
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34650737
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.34444945
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34195244
91* NANOG_21062744_ChIP-ChIP_HESCs_Human1.33123929
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32040033
93KDM5A_27292631_Chip-Seq_BREAST_Human1.31892434
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31859346
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31292722
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31217268
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30698755
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30252431
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29852898
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29321879
101* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28821618
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27073837
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25904453
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25115926
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.24949181
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24905776
107FOXP3_21729870_ChIP-Seq_TREG_Human1.24563271
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23616248
109CTCF_27219007_Chip-Seq_Bcells_Human1.22883303
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21447450
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20997657
112* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20403206
113TP53_20018659_ChIP-ChIP_R1E_Mouse1.19934766
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19711876
115SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19513704
116ATF3_27146783_Chip-Seq_COLON_Human1.18547893
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18196674
118VDR_23849224_ChIP-Seq_CD4+_Human1.17154584
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16084457
120* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15985687
121DCP1A_22483619_ChIP-Seq_HELA_Human1.15933846
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.15294127
123VDR_21846776_ChIP-Seq_THP-1_Human1.14715232
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14165576
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13923228
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13413218
127GABP_19822575_ChIP-Seq_HepG2_Human1.12983582
128YY1_21170310_ChIP-Seq_MESCs_Mouse1.12973005
129VDR_24763502_ChIP-Seq_THP-1_Human1.12437664
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11706401
131* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11139624
132UBF1/2_26484160_Chip-Seq_HMECs_Human1.10460596
133EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10239186
134RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10239186
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09263321
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08755684
137POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07679592
138TET1_21490601_ChIP-Seq_MESCs_Mouse1.06144654
139TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03433420
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03285431
141NCOR1_26117541_ChIP-Seq_K562_Human1.01969862
142* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01726684
143SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01548449
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99956157
145GABP_17652178_ChIP-ChIP_JURKAT_Human0.99367519
146JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99029253
147TP63_17297297_ChIP-ChIP_HaCaT_Human0.98983138
148SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98875440
149OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98656940
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98344428
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97139279
152NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96471418
153TP53_23651856_ChIP-Seq_MEFs_Mouse0.96268498
154POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95704117
155GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95468530
156NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94786332
157HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94723290
158RNF2_27304074_Chip-Seq_ESCs_Mouse0.94237088
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93940249
160SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93870702
161MAF_26560356_Chip-Seq_TH1_Human0.93702200
162ELF1_20517297_ChIP-Seq_JURKAT_Human0.93436264
163MAF_26560356_Chip-Seq_TH2_Human0.92812978
164ZNF263_19887448_ChIP-Seq_K562_Human0.92136302
165CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91688311
166SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91488251
167EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91364000
168RARB_27405468_Chip-Seq_BRAIN_Mouse0.91340959
169SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91323796
170* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91041767
171PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90616851
172E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90372952
173* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89767542
174ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88534396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.87983725
2MP0003693_abnormal_embryo_hatching3.71757143
3MP0003111_abnormal_nucleus_morphology3.60337826
4MP0004957_abnormal_blastocyst_morpholog3.60179505
5MP0004858_abnormal_nervous_system3.57691826
6MP0010094_abnormal_chromosome_stability3.34927249
7MP0003077_abnormal_cell_cycle2.98928848
8MP0008057_abnormal_DNA_replication2.86220918
9MP0003941_abnormal_skin_development2.80918013
10MP0003123_paternal_imprinting2.64142822
11MP0010030_abnormal_orbit_morphology2.53004289
12MP0010352_gastrointestinal_tract_polyps2.46219130
13MP0002653_abnormal_ependyma_morphology2.42755392
14MP0005409_darkened_coat_color2.38457029
15MP0005257_abnormal_intraocular_pressure2.33293738
16MP0008058_abnormal_DNA_repair2.30917626
17MP0003279_aneurysm2.26274490
18MP0001293_anophthalmia2.25674757
19MP0010368_abnormal_lymphatic_system2.24647949
20MP0008932_abnormal_embryonic_tissue2.24521567
21MP0001730_embryonic_growth_arrest2.21179864
22MP0005076_abnormal_cell_differentiation2.20346174
23MP0004133_heterotaxia2.19759606
24MP0003119_abnormal_digestive_system2.19677686
25MP0000350_abnormal_cell_proliferation2.15220671
26MP0008007_abnormal_cellular_replicative2.11581412
27MP0002085_abnormal_embryonic_tissue2.06794838
28MP0003890_abnormal_embryonic-extraembry2.05935640
29MP0002084_abnormal_developmental_patter2.02172951
30MP0004197_abnormal_fetal_growth/weight/2.01980113
31MP0005380_embryogenesis_phenotype1.98976775
32MP0001672_abnormal_embryogenesis/_devel1.98976775
33MP0003705_abnormal_hypodermis_morpholog1.96389305
34MP0003283_abnormal_digestive_organ1.94851226
35MP0002877_abnormal_melanocyte_morpholog1.93616996
36MP0004272_abnormal_basement_membrane1.93117391
37MP0001697_abnormal_embryo_size1.85261554
38MP0005503_abnormal_tendon_morphology1.82056291
39MP0003091_abnormal_cell_migration1.78057579
40MP0003984_embryonic_growth_retardation1.75479017
41MP0002088_abnormal_embryonic_growth/wei1.73443611
42MP0001958_emphysema1.71941364
43MP0000751_myopathy1.69286443
44MP0006292_abnormal_olfactory_placode1.66122325
45MP0002086_abnormal_extraembryonic_tissu1.65512668
46MP0000537_abnormal_urethra_morphology1.65256208
47MP0009053_abnormal_anal_canal1.63616459
48MP0003121_genomic_imprinting1.63318587
49MP0000767_abnormal_smooth_muscle1.62774192
50MP0003567_abnormal_fetal_cardiomyocyte1.62537998
51MP0005451_abnormal_body_composition1.61652059
52MP0002080_prenatal_lethality1.57316399
53MP0000534_abnormal_ureter_morphology1.55379590
54MP0005275_abnormal_skin_tensile1.53500956
55MP0010307_abnormal_tumor_latency1.49104178
56MP0002060_abnormal_skin_morphology1.48142597
57MP0009672_abnormal_birth_weight1.47130288
58MP0003786_premature_aging1.41462081
59MP0005058_abnormal_lysosome_morphology1.40910180
60MP0000003_abnormal_adipose_tissue1.38475204
61MP0005508_abnormal_skeleton_morphology1.37792281
62MP0002089_abnormal_postnatal_growth/wei1.37768254
63MP0008877_abnormal_DNA_methylation1.37075112
64MP0002697_abnormal_eye_size1.35213056
65MP0002796_impaired_skin_barrier1.31661791
66MP0008789_abnormal_olfactory_epithelium1.31395221
67MP0009703_decreased_birth_body1.31089727
68MP0002111_abnormal_tail_morphology1.29863170
69MP0001286_abnormal_eye_development1.28968032
70MP0002249_abnormal_larynx_morphology1.25425059
71MP0003861_abnormal_nervous_system1.25415830
72MP0003453_abnormal_keratinocyte_physiol1.25132000
73MP0005623_abnormal_meninges_morphology1.24342152
74MP0005394_taste/olfaction_phenotype1.23064984
75MP0005499_abnormal_olfactory_system1.23064984
76MP0005375_adipose_tissue_phenotype1.22659391
77MP0006138_congestive_heart_failure1.22563730
78MP0004859_abnormal_synaptic_plasticity1.22551167
79MP0000579_abnormal_nail_morphology1.21773964
80MP0005666_abnormal_adipose_tissue1.21734020
81MP0002092_abnormal_eye_morphology1.21204190
82MP0005670_abnormal_white_adipose1.19602295
83MP0009384_cardiac_valve_regurgitation1.19338569
84MP0000428_abnormal_craniofacial_morphol1.16931330
85MP0001849_ear_inflammation1.16902756
86MP0000313_abnormal_cell_death1.16369957
87MP0003935_abnormal_craniofacial_develop1.15932051
88MP0000516_abnormal_urinary_system1.15534196
89MP0005367_renal/urinary_system_phenotyp1.15534196
90MP0000049_abnormal_middle_ear1.15462831
91MP0009250_abnormal_appendicular_skeleto1.15410238
92MP0000432_abnormal_head_morphology1.14990043
93MP0000762_abnormal_tongue_morphology1.10419429
94MP0002396_abnormal_hematopoietic_system1.09657323
95MP0000759_abnormal_skeletal_muscle1.08554235
96MP0003755_abnormal_palate_morphology1.05760450
97MP0003115_abnormal_respiratory_system1.05093973
98MP0005501_abnormal_skin_physiology1.04932487
99MP0010234_abnormal_vibrissa_follicle1.03828151
100MP0003937_abnormal_limbs/digits/tail_de1.03746995
101MP0002896_abnormal_bone_mineralization0.99375686
102MP0004233_abnormal_muscle_weight0.99251255
103MP0010630_abnormal_cardiac_muscle0.98752074
104MP0000490_abnormal_crypts_of0.98658822
105MP0002233_abnormal_nose_morphology0.97383133
106MP0003385_abnormal_body_wall0.95674765
107MP0002116_abnormal_craniofacial_bone0.95264647
108MP0002210_abnormal_sex_determination0.94948559
109MP0000678_abnormal_parathyroid_gland0.94583419
110MP0000462_abnormal_digestive_system0.93227023
111MP0002108_abnormal_muscle_morphology0.92850466
112MP0001145_abnormal_male_reproductive0.91906694
113MP0002925_abnormal_cardiovascular_devel0.89765116
114MP0000733_abnormal_muscle_development0.87916642
115MP0003329_amyloid_beta_deposits0.87816803
116MP0002932_abnormal_joint_morphology0.86147688
117MP0001879_abnormal_lymphatic_vessel0.84710499
118MP0003315_abnormal_perineum_morphology0.84555526
119MP0003566_abnormal_cell_adhesion0.84338263
120MP0003942_abnormal_urinary_system0.84221162
121MP0002019_abnormal_tumor_incidence0.84129745
122MP0009278_abnormal_bone_marrow0.83582758
123MP0003787_abnormal_imprinting0.82709510
124MP0009840_abnormal_foam_cell0.82495251
125MP0005248_abnormal_Harderian_gland0.82252051
126MP0008260_abnormal_autophagy0.81238999
127MP0002114_abnormal_axial_skeleton0.80392160
128MP0002113_abnormal_skeleton_development0.80206037
129MP0004087_abnormal_muscle_fiber0.79929335
130MP0008770_decreased_survivor_rate0.79354603
131MP0003634_abnormal_glial_cell0.79044314
132MP0000566_synostosis0.78437842
133MP0001915_intracranial_hemorrhage0.78376194
134MP0000858_altered_metastatic_potential0.78096300
135MP0001346_abnormal_lacrimal_gland0.78012801
136MP0001348_abnormal_lacrimal_gland0.77624334
137MP0002081_perinatal_lethality0.77132260
138MP0005621_abnormal_cell_physiology0.76968879
139MP0000750_abnormal_muscle_regeneration0.75178327
140MP0001614_abnormal_blood_vessel0.74880965
141MP0004185_abnormal_adipocyte_glucose0.74807258
142MP0003300_gastrointestinal_ulcer0.74129118
143MP0000467_abnormal_esophagus_morphology0.73952391
144MP0005377_hearing/vestibular/ear_phenot0.73429432
145MP0003878_abnormal_ear_physiology0.73429432
146MP0000653_abnormal_sex_gland0.72665747
147MP0002751_abnormal_autonomic_nervous0.72124577
148MP0003136_yellow_coat_color0.70794071
149MP0009379_abnormal_foot_pigmentation0.70517324
150MP0001340_abnormal_eyelid_morphology0.70122821
151MP0000703_abnormal_thymus_morphology0.70095965
152MP0005023_abnormal_wound_healing0.69864804
153MP0002234_abnormal_pharynx_morphology0.69861472
154MP0000163_abnormal_cartilage_morphology0.69365515
155MP0003938_abnormal_ear_development0.68998545
156MP0002098_abnormal_vibrissa_morphology0.67972356
157MP0005390_skeleton_phenotype0.66753460

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.43660397
2Premature rupture of membranes (HP:0001788)4.18254675
3Obstructive sleep apnea (HP:0002870)3.85954970
4Ependymoma (HP:0002888)3.81246080
5Abnormality of the labia minora (HP:0012880)3.43104366
6Selective tooth agenesis (HP:0001592)3.35322891
7Colon cancer (HP:0003003)3.32249748
8Medulloblastoma (HP:0002885)3.25202007
9Reticulocytopenia (HP:0001896)3.21684004
10Disproportionate tall stature (HP:0001519)3.08623753
11Abnormality of the astrocytes (HP:0100707)3.07161879
12Astrocytoma (HP:0009592)3.07161879
13Ulnar bowing (HP:0003031)2.98561738
14Absent radius (HP:0003974)2.96862002
15Broad face (HP:0000283)2.95581538
16Chromsome breakage (HP:0040012)2.95426489
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93699659
18Cerebral aneurysm (HP:0004944)2.88123025
19Rib fusion (HP:0000902)2.86331478
20Absent forearm bone (HP:0003953)2.84670365
21Aplasia involving forearm bones (HP:0009822)2.84670365
22Spinal rigidity (HP:0003306)2.82503344
23Renal duplication (HP:0000075)2.80797850
24Genu recurvatum (HP:0002816)2.78219580
25Long palpebral fissure (HP:0000637)2.76055514
26Fragile skin (HP:0001030)2.75001434
27Patellar aplasia (HP:0006443)2.69693205
28Abnormal number of incisors (HP:0011064)2.66242061
29Bladder diverticulum (HP:0000015)2.65978599
30Increased nuchal translucency (HP:0010880)2.64057362
31Breast hypoplasia (HP:0003187)2.60628526
32Glioma (HP:0009733)2.59553619
33Neoplasm of the oral cavity (HP:0100649)2.59441644
34Supernumerary spleens (HP:0009799)2.56184053
35Supernumerary ribs (HP:0005815)2.55810578
36Supernumerary bones of the axial skeleton (HP:0009144)2.55337993
37Rhabdomyosarcoma (HP:0002859)2.54102719
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.53520383
39Ankle contracture (HP:0006466)2.53505753
40Aplasia/Hypoplasia of the patella (HP:0006498)2.52586883
41Sparse lateral eyebrow (HP:0005338)2.51554301
42Increased connective tissue (HP:0009025)2.51226798
43Distal upper limb amyotrophy (HP:0007149)2.48765376
44Upper limb amyotrophy (HP:0009129)2.48765376
45Short 4th metacarpal (HP:0010044)2.48706812
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48706812
47Distal lower limb amyotrophy (HP:0008944)2.48386083
48Neoplasm of striated muscle (HP:0009728)2.47100659
49Turricephaly (HP:0000262)2.46909359
50Blue sclerae (HP:0000592)2.45171530
51Abnormality of abdominal situs (HP:0011620)2.44089025
52Abdominal situs inversus (HP:0003363)2.44089025
53Mitral regurgitation (HP:0001653)2.43964460
54Hyperacusis (HP:0010780)2.43821000
55Increased variability in muscle fiber diameter (HP:0003557)2.43379358
56Broad metatarsal (HP:0001783)2.40941532
57Atrophic scars (HP:0001075)2.38842469
58Cervical subluxation (HP:0003308)2.38738685
59Absent thumb (HP:0009777)2.38029955
60Meckel diverticulum (HP:0002245)2.34324593
61Missing ribs (HP:0000921)2.33730419
62Vertebral compression fractures (HP:0002953)2.33248712
63Shawl scrotum (HP:0000049)2.32200483
64High anterior hairline (HP:0009890)2.31696242
65Abnormality of the ileum (HP:0001549)2.29738412
66Aplasia/hypoplasia of the humerus (HP:0006507)2.29713158
67Ectopic kidney (HP:0000086)2.29691477
68Abnormality of the fingertips (HP:0001211)2.29047867
69Birth length less than 3rd percentile (HP:0003561)2.28744966
70Neonatal short-limb short stature (HP:0008921)2.28391572
71Achilles tendon contracture (HP:0001771)2.28164004
72Duplicated collecting system (HP:0000081)2.27838770
73Renovascular hypertension (HP:0100817)2.27543682
74Insomnia (HP:0100785)2.26280270
75Proximal placement of thumb (HP:0009623)2.25817610
76Pseudobulbar signs (HP:0002200)2.25093738
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.24748831
78Atresia of the external auditory canal (HP:0000413)2.24409141
79Asymmetry of the thorax (HP:0001555)2.23167929
80Mildly elevated creatine phosphokinase (HP:0008180)2.21369632
81Premature skin wrinkling (HP:0100678)2.16801432
82Deviation of the thumb (HP:0009603)2.15435035
83Thin bony cortex (HP:0002753)2.13493165
84Anal stenosis (HP:0002025)2.13417620
85Mitral valve prolapse (HP:0001634)2.12911947
86Esophageal atresia (HP:0002032)2.12040229
87Abnormality of the lower motor neuron (HP:0002366)2.11128569
88Vascular tortuosity (HP:0004948)2.10820987
89Tracheoesophageal fistula (HP:0002575)2.10503201
90Short humerus (HP:0005792)2.08393552
91Carpal bone hypoplasia (HP:0001498)2.08322739
92Elfin facies (HP:0004428)2.08180626
93Natal tooth (HP:0000695)2.07462038
94Degeneration of anterior horn cells (HP:0002398)2.06774186
95Abnormality of the anterior horn cell (HP:0006802)2.06774186
96Abnormality of the distal phalanx of the thumb (HP:0009617)2.06412888
97Abnormality of the phalanges of the hallux (HP:0010057)2.05366277
98Lower limb amyotrophy (HP:0007210)2.05135799
99Biconcave vertebral bodies (HP:0004586)2.05020285
100Thin ribs (HP:0000883)2.03771142
101Facial hemangioma (HP:0000329)2.03454200
102Abnormality of skeletal muscle fiber size (HP:0012084)2.03062344
103Oral leukoplakia (HP:0002745)2.02751263
104Joint laxity (HP:0001388)2.01340375
105Abnormality of the diencephalon (HP:0010662)2.01010963
106Wormian bones (HP:0002645)2.00317729
107Overriding aorta (HP:0002623)2.00124236
108Abnormal lung lobation (HP:0002101)1.99749068
109Long eyelashes (HP:0000527)1.99487082
110Skull defect (HP:0001362)1.99424593
111Malignant gastrointestinal tract tumors (HP:0006749)1.99328429
112Gastrointestinal carcinoma (HP:0002672)1.99328429
113Basal cell carcinoma (HP:0002671)1.99238767
114Abnormality of chromosome stability (HP:0003220)1.99052999
115Arterial tortuosity (HP:0005116)1.98267852
116Advanced eruption of teeth (HP:0006288)1.98181917
117Type 1 muscle fiber predominance (HP:0003803)1.98136903
118Anophthalmia (HP:0000528)1.97597902
119Aortic aneurysm (HP:0004942)1.97212967
120Nephroblastoma (Wilms tumor) (HP:0002667)1.96552866
121Impulsivity (HP:0100710)1.96148176
122Acute lymphatic leukemia (HP:0006721)1.95564570
123Spinal muscular atrophy (HP:0007269)1.94702925
124Abnormality of the distal phalanges of the toes (HP:0010182)1.94030932
125Abnormality of the carotid arteries (HP:0005344)1.93975652
126Abnormality of the Achilles tendon (HP:0005109)1.93889275
127Skin tags (HP:0010609)1.93382047
128Neoplasm of the pancreas (HP:0002894)1.92970645
129Hyperextensible skin (HP:0000974)1.92223261
130Aortic dissection (HP:0002647)1.91312162
131Slender build (HP:0001533)1.91201435
132Abnormality of the preputium (HP:0100587)1.91124565
133Patellar dislocation (HP:0002999)1.91089908
134Intestinal fistula (HP:0100819)1.90366431
135Flat acetabular roof (HP:0003180)1.90132783
136Abnormality of the renal collecting system (HP:0004742)1.88957912
137Abnormality of dentin (HP:0010299)1.88485682
138Short thumb (HP:0009778)1.88129173
139Preauricular skin tag (HP:0000384)1.88092842
140Oligodactyly (HP:0012165)1.87464340
141Trismus (HP:0000211)1.87297475
142Shallow orbits (HP:0000586)1.87084498
143Vertebral fusion (HP:0002948)1.86861245
144Precocious puberty (HP:0000826)1.86691053
145Pointed chin (HP:0000307)1.86164844
146Annular pancreas (HP:0001734)1.86099295
147Generalized amyotrophy (HP:0003700)1.86034941
148Bowel diverticulosis (HP:0005222)1.85509357
149Hypoventilation (HP:0002791)1.84638158
150Short 1st metacarpal (HP:0010034)1.84224614
151Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84224614
152Horseshoe kidney (HP:0000085)1.84080565
153Bilateral microphthalmos (HP:0007633)1.83160508
154Hemivertebrae (HP:0002937)1.82852767
155Dilatation of the ascending aorta (HP:0005111)1.82789749
156Triphalangeal thumb (HP:0001199)1.82135970
157Arnold-Chiari malformation (HP:0002308)1.82000880
158Abnormality of the 4th metacarpal (HP:0010012)1.80959831
159Hyperparathyroidism (HP:0000843)1.80939696
160Broad thumb (HP:0011304)1.80442365
161Embryonal renal neoplasm (HP:0011794)1.80429326
162Aneurysm (HP:0002617)1.80157587
163Short phalanx of the thumb (HP:0009660)1.79731604
164Dislocated radial head (HP:0003083)1.79250830
165Abnormality of the radial head (HP:0003995)1.78252189
166Rectal fistula (HP:0100590)1.76779782
167Rectovaginal fistula (HP:0000143)1.76779782
168Deviation of the hallux (HP:0010051)1.76401465
169Abnormality of the aortic arch (HP:0012303)1.76185336
170Volvulus (HP:0002580)1.76034309
171Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75483988
172Wide anterior fontanel (HP:0000260)1.73238374
173Bowing of the arm (HP:0006488)1.72985311
174Bowed forearm bones (HP:0003956)1.72985311
175Stridor (HP:0010307)1.71730223
176Congenital glaucoma (HP:0001087)1.70638452
177Centrally nucleated skeletal muscle fibers (HP:0003687)1.70626483
178Urethral obstruction (HP:0000796)1.70231445
179Lymphangioma (HP:0100764)1.69829976
180Abnormality of the thoracic spine (HP:0100711)1.68561500
181Elbow flexion contracture (HP:0002987)1.68524033
182Congenital hip dislocation (HP:0001374)1.67642157
183Hallux valgus (HP:0001822)1.67583110
184Aplasia involving bones of the upper limbs (HP:0009823)1.67524789
185Aplasia of the phalanges of the hand (HP:0009802)1.67524789
186Aplasia involving bones of the extremities (HP:0009825)1.67524789
187Difficulty climbing stairs (HP:0003551)1.64986029
188Distal lower limb muscle weakness (HP:0009053)1.64387295
189Venous abnormality (HP:0002624)1.64106005
190Soft skin (HP:0000977)1.63730389
191Broad distal phalanx of finger (HP:0009836)1.63226510
192Hypercalcemia (HP:0003072)1.62453962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.79266076
2CDC74.13097622
3SMG13.42083877
4SIK13.18711019
5PRPF4B2.89292325
6NEK22.83443056
7MAP3K102.74649518
8TLK12.56027307
9IRAK32.50594260
10SRPK12.44054589
11WEE12.41356408
12TTK2.40981538
13NEK12.29038081
14EPHA22.24171578
15MKNK22.18618514
16EEF2K2.15945931
17BRD42.13763350
18ERN12.11028136
19CDK72.05744819
20ALK2.03728492
21BUB12.02670336
22PKN21.94179093
23ICK1.91338169
24MKNK11.89916459
25RPS6KB21.89050559
26PLK11.80183624
27LATS21.72825270
28ATR1.62594659
29PASK1.56851453
30CHEK21.46009559
31NTRK11.45950611
32CDK41.42455821
33PTK21.41879125
34EIF2AK11.41047883
35* CHEK11.38071108
36MTOR1.38069659
37MAP3K31.35613905
38AURKB1.33902407
39TESK21.30368899
40DYRK31.23354985
41MAP3K81.21800466
42FGFR41.20088818
43RPS6KA21.18621022
44PLK31.16607255
45CDK21.16176358
46TSSK61.15337286
47PAK41.15159445
48TRIB31.15091423
49ATM1.13264580
50AURKA1.08946847
51TAOK21.06220105
52CDK61.05504882
53LATS11.04428579
54PNCK1.03168725
55ARAF0.99153127
56KSR20.98977226
57RPS6KC10.98253870
58RPS6KL10.98253870
59ILK0.97153059
60PRKCI0.91952284
61RIPK10.88802787
62MAP3K20.87255637
63TYRO30.85229584
64CDK10.84217074
65BMX0.82406512
66PLK40.81579195
67STK240.80897632
68LMTK20.80425783
69CSNK1E0.80386896
70CDC42BPA0.80305281
71MAP3K110.80032156
72STK40.79537139
73MAP2K30.78907554
74PTK60.78073546
75PRKD30.77745120
76AKT20.76688995
77RPS6KA60.76069680
78AKT30.75730016
79FGFR10.75454007
80FLT30.74797482
81DYRK20.74506325
82VRK10.73800417
83STK100.73378319
84CAMKK10.72343287
85MAP3K130.71920444
86PDGFRA0.71449285
87PDPK10.70800026
88HIPK20.70758984
89EPHB10.70184995
90BRAF0.69844167
91IRAK20.69721233
92EPHB20.69704009
93MAP3K90.69628942
94BRSK20.68255404
95STK380.66773466
96BRSK10.65823304
97RPS6KA40.64976890
98PRKDC0.64541259
99MOS0.63907203
100DDR20.63831006
101SCYL20.62668577
102CSNK1D0.62599832
103STK38L0.61547064
104MAP3K10.58512507
105UHMK10.58172554
106CSNK2A20.57723159
107MAPK140.57718475
108PAK20.56775574
109NME20.55272112
110CLK10.55044105
111DMPK0.53661705
112PIM10.52594055
113MAPK110.51672063
114CDK90.51472774
115PAK10.50641341
116PDGFRB0.50394335
117MST1R0.49700931
118GSK3B0.49599914
119MAP2K20.49566032
120MAP3K60.48579768
121LRRK20.48578372
122TTN0.48308113
123PRKD20.47777298
124WNK10.47083728
125AKT10.46529176
126MAPKAPK30.45902943
127MET0.45868086
128MARK10.44907894
129DYRK1B0.44541717
130PIM20.44113719
131SGK30.44100514
132RPS6KA10.43872788
133RET0.43334305
134CAMK1D0.42833716
135ACVR1B0.42148674
136SIK20.41766078
137PAK60.40244401
138PRKCH0.39786129
139MAP3K70.39452450
140TAOK10.39283663
141SIK30.39260584
142CSNK2A10.39006662
143* MAPK10.38827923
144JAK30.38661403
145PRKG20.38502931
146MAPK120.38202050
147CAMK40.37095966
148CDK11A0.35583410
149MAPK100.35462556
150MELK0.35358076
151CAMK1G0.35142868
152CAMK10.35091584
153ZAK0.34646756
154NTRK20.33796416
155MARK20.33200989
156STK30.33113890
157CDK150.31638798
158ERBB20.30739823
159TESK10.30733202
160CHUK0.28979972

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.08553248
2Mismatch repair_Homo sapiens_hsa034303.99082944
3Spliceosome_Homo sapiens_hsa030403.68654259
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56595919
5RNA transport_Homo sapiens_hsa030133.27152470
6Ribosome_Homo sapiens_hsa030103.09388809
7One carbon pool by folate_Homo sapiens_hsa006703.03165384
8mRNA surveillance pathway_Homo sapiens_hsa030152.63576212
9Base excision repair_Homo sapiens_hsa034102.55938877
10Homologous recombination_Homo sapiens_hsa034402.51547118
11Cell cycle_Homo sapiens_hsa041102.50686796
12Fanconi anemia pathway_Homo sapiens_hsa034602.50380401
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41607374
14RNA polymerase_Homo sapiens_hsa030202.28657920
15Nucleotide excision repair_Homo sapiens_hsa034202.24508946
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02686654
17Basal cell carcinoma_Homo sapiens_hsa052171.91569111
18RNA degradation_Homo sapiens_hsa030181.67501878
19Prion diseases_Homo sapiens_hsa050201.66225149
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63317186
21Non-homologous end-joining_Homo sapiens_hsa034501.60870030
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59299330
23Pyrimidine metabolism_Homo sapiens_hsa002401.58378029
24p53 signaling pathway_Homo sapiens_hsa041151.55522812
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54921175
26Notch signaling pathway_Homo sapiens_hsa043301.54774480
27Lysine degradation_Homo sapiens_hsa003101.47438878
28Hippo signaling pathway_Homo sapiens_hsa043901.46040190
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41025483
30MicroRNAs in cancer_Homo sapiens_hsa052061.40743384
31Hedgehog signaling pathway_Homo sapiens_hsa043401.36328292
32Basal transcription factors_Homo sapiens_hsa030221.34815419
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20364946
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.20220516
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18278609
36Other glycan degradation_Homo sapiens_hsa005111.17932474
37Oocyte meiosis_Homo sapiens_hsa041141.16313375
38GnRH signaling pathway_Homo sapiens_hsa049121.16145604
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11448838
40Amoebiasis_Homo sapiens_hsa051461.10973093
41Thyroid cancer_Homo sapiens_hsa052161.05377032
42mTOR signaling pathway_Homo sapiens_hsa041501.03712344
43Colorectal cancer_Homo sapiens_hsa052101.02708655
44Systemic lupus erythematosus_Homo sapiens_hsa053221.02068055
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.01966623
46Choline metabolism in cancer_Homo sapiens_hsa052311.01554023
47Adherens junction_Homo sapiens_hsa045201.01077298
48HTLV-I infection_Homo sapiens_hsa051661.00782765
49Viral carcinogenesis_Homo sapiens_hsa052030.99234951
50Long-term potentiation_Homo sapiens_hsa047200.98332848
51Epstein-Barr virus infection_Homo sapiens_hsa051690.97665680
52Wnt signaling pathway_Homo sapiens_hsa043100.97319842
53Dilated cardiomyopathy_Homo sapiens_hsa054140.96963441
54TGF-beta signaling pathway_Homo sapiens_hsa043500.95969318
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.95695332
56Chronic myeloid leukemia_Homo sapiens_hsa052200.94783549
57Small cell lung cancer_Homo sapiens_hsa052220.94676181
58Bladder cancer_Homo sapiens_hsa052190.92385942
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89885307
60Prolactin signaling pathway_Homo sapiens_hsa049170.88287767
61Fatty acid biosynthesis_Homo sapiens_hsa000610.88247892
62Endometrial cancer_Homo sapiens_hsa052130.85489252
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82526265
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81714718
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79855840
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.78848077
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77464637
68Pathways in cancer_Homo sapiens_hsa052000.76958311
69Endocytosis_Homo sapiens_hsa041440.75885388
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75765131
71Tight junction_Homo sapiens_hsa045300.75024938
72B cell receptor signaling pathway_Homo sapiens_hsa046620.73074747
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.72719249
74Herpes simplex infection_Homo sapiens_hsa051680.71974120
75Inositol phosphate metabolism_Homo sapiens_hsa005620.71188985
76Pentose phosphate pathway_Homo sapiens_hsa000300.69719666
77Acute myeloid leukemia_Homo sapiens_hsa052210.69469670
78Purine metabolism_Homo sapiens_hsa002300.68111057
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.67855811
80Hepatitis C_Homo sapiens_hsa051600.66337641
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65945545
82Selenocompound metabolism_Homo sapiens_hsa004500.65076401
83Insulin resistance_Homo sapiens_hsa049310.64436643
84Biosynthesis of amino acids_Homo sapiens_hsa012300.64118540
85Cholinergic synapse_Homo sapiens_hsa047250.62211958
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.62099093
87Vibrio cholerae infection_Homo sapiens_hsa051100.61936490
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61294736
89Proteoglycans in cancer_Homo sapiens_hsa052050.61211386
90Melanoma_Homo sapiens_hsa052180.60652447
91TNF signaling pathway_Homo sapiens_hsa046680.59774685
92Glucagon signaling pathway_Homo sapiens_hsa049220.59307602
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59278129
94Non-small cell lung cancer_Homo sapiens_hsa052230.58182083
95Viral myocarditis_Homo sapiens_hsa054160.57993355
96Fructose and mannose metabolism_Homo sapiens_hsa000510.57945216
97Alcoholism_Homo sapiens_hsa050340.57615611
98Oxytocin signaling pathway_Homo sapiens_hsa049210.55636514
99Prostate cancer_Homo sapiens_hsa052150.55335111
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55115001
101Proteasome_Homo sapiens_hsa030500.54521156
102Cocaine addiction_Homo sapiens_hsa050300.52775869
103Melanogenesis_Homo sapiens_hsa049160.47721958
104HIF-1 signaling pathway_Homo sapiens_hsa040660.43475193
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40783083
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40632562
107Glioma_Homo sapiens_hsa052140.39358925
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37274573
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.36707789
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36373123
111Apoptosis_Homo sapiens_hsa042100.36334750
112Antigen processing and presentation_Homo sapiens_hsa046120.35633923
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33413434
114Pancreatic cancer_Homo sapiens_hsa052120.32982077
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32866097
116Renal cell carcinoma_Homo sapiens_hsa052110.31446702
117Focal adhesion_Homo sapiens_hsa045100.30542051
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30485816
119Rap1 signaling pathway_Homo sapiens_hsa040150.30190546
120Insulin signaling pathway_Homo sapiens_hsa049100.30087846
121Axon guidance_Homo sapiens_hsa043600.29891076
122ErbB signaling pathway_Homo sapiens_hsa040120.28967772
123VEGF signaling pathway_Homo sapiens_hsa043700.28897694
124AMPK signaling pathway_Homo sapiens_hsa041520.26564611
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26159776
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25941837
127FoxO signaling pathway_Homo sapiens_hsa040680.25641222
128Hepatitis B_Homo sapiens_hsa051610.23791474
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.23649356
130Estrogen signaling pathway_Homo sapiens_hsa049150.21913999
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21353918
132Sulfur relay system_Homo sapiens_hsa041220.19830105
133Gap junction_Homo sapiens_hsa045400.19460020
134ECM-receptor interaction_Homo sapiens_hsa045120.18031086
135Protein digestion and absorption_Homo sapiens_hsa049740.17683690
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16653423
137MAPK signaling pathway_Homo sapiens_hsa040100.14851823
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12487404
139Dorso-ventral axis formation_Homo sapiens_hsa043200.12007635

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