WLS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.86377148
2Golgi transport vesicle coating (GO:0048200)4.86377148
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.47250520
4cellular response to vitamin D (GO:0071305)4.39577050
5collagen fibril organization (GO:0030199)4.28201790
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.18758397
7glomerular basement membrane development (GO:0032836)4.07058489
8regulation of axon guidance (GO:1902667)3.86436987
9cellular response to vitamin (GO:0071295)3.85792528
10renal filtration (GO:0097205)3.84357304
11cell surface receptor signaling pathway involved in heart development (GO:0061311)3.83098181
12protein retention in ER lumen (GO:0006621)3.80972477
13regulation of cardioblast differentiation (GO:0051890)3.79864833
14glomerular filtration (GO:0003094)3.74697613
15axon extension involved in axon guidance (GO:0048846)3.70874168
16neuron projection extension involved in neuron projection guidance (GO:1902284)3.70874168
17chondrocyte proliferation (GO:0035988)3.63269573
18signal peptide processing (GO:0006465)3.58373169
19paraxial mesoderm development (GO:0048339)3.55835014
20regulation of axon extension involved in axon guidance (GO:0048841)3.55156553
21cell proliferation involved in metanephros development (GO:0072203)3.52489105
22Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.51299387
23sequestering of metal ion (GO:0051238)3.49433429
24axis elongation (GO:0003401)3.48657511
25establishment of tissue polarity (GO:0007164)3.45543888
26establishment of planar polarity (GO:0001736)3.45543888
27regulation of establishment of planar polarity (GO:0090175)3.41586387
28cell proliferation involved in kidney development (GO:0072111)3.36062072
29chondrocyte development (GO:0002063)3.35884878
30ER overload response (GO:0006983)3.29819869
31positive regulation of gastrulation (GO:2000543)3.29053494
32lens fiber cell development (GO:0070307)3.27108009
33branching involved in salivary gland morphogenesis (GO:0060445)3.22991244
34type B pancreatic cell development (GO:0003323)3.20154045
35protein heterotrimerization (GO:0070208)3.19237495
36negative regulation of chondrocyte differentiation (GO:0032331)3.18530031
37negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.18168228
38craniofacial suture morphogenesis (GO:0097094)3.16528669
39presynaptic membrane assembly (GO:0097105)3.10214933
40bone trabecula formation (GO:0060346)3.10130049
41notochord development (GO:0030903)3.04804096
42non-canonical Wnt signaling pathway (GO:0035567)3.04715715
43cell adhesion mediated by integrin (GO:0033627)3.03230481
44apical protein localization (GO:0045176)3.03055014
45convergent extension (GO:0060026)3.01225161
46sequestering of extracellular ligand from receptor (GO:0035581)3.01160430
47negative regulation of fatty acid transport (GO:2000192)3.00528311
48spinal cord association neuron differentiation (GO:0021527)2.98084569
49regulation of osteoblast proliferation (GO:0033688)2.97747956
50mesenchyme morphogenesis (GO:0072132)2.97706841
51metanephric mesenchyme development (GO:0072075)2.97011177
52endodermal cell differentiation (GO:0035987)2.95520909
53regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.95507485
54regulation of mesenchymal cell apoptotic process (GO:2001053)2.93886647
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.91578385
56outer ear morphogenesis (GO:0042473)2.91398330
57myoblast fusion (GO:0007520)2.88962064
58positive regulation of mesenchymal cell proliferation (GO:0002053)2.88229810
59postsynaptic membrane organization (GO:0001941)2.88204678
60collagen metabolic process (GO:0032963)2.87991714
61mesenchymal-epithelial cell signaling (GO:0060638)2.86477799
62negative regulation of axon guidance (GO:1902668)2.85471116
63axonemal dynein complex assembly (GO:0070286)2.84965248
64negative regulation of osteoblast proliferation (GO:0033689)2.83965272
65negative regulation of cartilage development (GO:0061037)2.83286668
66negative regulation of cell fate specification (GO:0009996)2.83001453
67midbrain development (GO:0030901)2.82545938
68glomerular epithelial cell development (GO:0072310)2.82531525
69collagen catabolic process (GO:0030574)2.82271858
70skin morphogenesis (GO:0043589)2.78088085
71gland morphogenesis (GO:0022612)2.77984023
72negative regulation of axon extension involved in axon guidance (GO:0048843)2.77321710
73negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.77122205
74regulation of type B pancreatic cell apoptotic process (GO:2000674)2.76715152
75kidney mesenchyme development (GO:0072074)2.76589832
76mesenchymal cell proliferation (GO:0010463)2.76047530
77camera-type eye morphogenesis (GO:0048593)2.75608171
78regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75509498
79epithelial tube branching involved in lung morphogenesis (GO:0060441)2.71710368
80cranial suture morphogenesis (GO:0060363)2.71650761
81hemidesmosome assembly (GO:0031581)2.71002134
82wound healing, spreading of cells (GO:0044319)2.70527536
83response to vitamin D (GO:0033280)2.70116015
84Notch signaling involved in heart development (GO:0061314)2.67883336
85glandular epithelial cell development (GO:0002068)2.67811579
86multicellular organismal macromolecule metabolic process (GO:0044259)2.67775831
87regulation of apoptotic process involved in morphogenesis (GO:1902337)2.67733354
88astrocyte differentiation (GO:0048708)2.66991073
89muscle cell migration (GO:0014812)2.66796971
90photoreceptor cell differentiation (GO:0046530)2.66592677
91eye photoreceptor cell differentiation (GO:0001754)2.66592677
92negative regulation of embryonic development (GO:0045992)2.66225898
93exocrine pancreas development (GO:0031017)2.66046676
94regulation of mesenchymal cell proliferation (GO:0010464)2.65719846
95establishment of apical/basal cell polarity (GO:0035089)2.65286960
96wound healing, spreading of epidermal cells (GO:0035313)2.65119257
97establishment or maintenance of bipolar cell polarity (GO:0061245)2.64869804
98establishment or maintenance of apical/basal cell polarity (GO:0035088)2.64869804
99asymmetric protein localization (GO:0008105)2.63996913
100negative regulation of catenin import into nucleus (GO:0035414)2.62088187
101multicellular organismal catabolic process (GO:0044243)2.62000592
102positive regulation of catenin import into nucleus (GO:0035413)2.61969669
103ganglion development (GO:0061548)2.61787516
104positive regulation of osteoblast proliferation (GO:0033690)2.61705589
105axon extension (GO:0048675)2.60680384
106presynaptic membrane organization (GO:0097090)2.58771730
107membrane protein ectodomain proteolysis (GO:0006509)2.58199112
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.57821394
109axonal fasciculation (GO:0007413)2.57177618
110positive regulation of cartilage development (GO:0061036)2.56721863
111keratan sulfate catabolic process (GO:0042340)2.56104684
112midgut development (GO:0007494)2.55948218
113multicellular organismal metabolic process (GO:0044236)2.55754365
114limb bud formation (GO:0060174)2.55454170
115regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.54066118
116syncytium formation by plasma membrane fusion (GO:0000768)2.54018696
117regulation of organ formation (GO:0003156)2.53309184
118regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.52057651
119positive regulation of astrocyte differentiation (GO:0048711)2.51776011
120glial cell migration (GO:0008347)2.50925043
121middle ear morphogenesis (GO:0042474)2.50112991
122post-anal tail morphogenesis (GO:0036342)2.50010470
123positive regulation of embryonic development (GO:0040019)2.49984098
124induction of positive chemotaxis (GO:0050930)2.49580914
125prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.48721343
126apoptotic cell clearance (GO:0043277)2.48451580
127negative regulation of leukocyte chemotaxis (GO:0002689)2.48117484
128mesodermal cell differentiation (GO:0048333)2.47961053
129glomerular visceral epithelial cell development (GO:0072015)2.47892841
130lateral sprouting from an epithelium (GO:0060601)2.47742875
131lung lobe morphogenesis (GO:0060463)2.47533144
132extracellular matrix disassembly (GO:0022617)2.47405798
133dopaminergic neuron differentiation (GO:0071542)2.45767232
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.44955809
135mesenchymal cell differentiation (GO:0048762)2.44257388
136negative chemotaxis (GO:0050919)2.43542942
137branch elongation of an epithelium (GO:0060602)2.43485864
138lung vasculature development (GO:0060426)2.42855149
139establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.42533827
140positive regulation of bone mineralization (GO:0030501)2.42378136
141regulation of secondary heart field cardioblast proliferation (GO:0003266)2.42290941
142regulation of cardioblast proliferation (GO:0003264)2.42290941
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42111048
144cochlea morphogenesis (GO:0090103)2.42001073
145positive regulation of cardiac muscle cell differentiation (GO:2000727)2.41340369
146dermatan sulfate biosynthetic process (GO:0030208)2.41325901
147regulation of morphogenesis of a branching structure (GO:0060688)2.40551885
148embryonic foregut morphogenesis (GO:0048617)2.40057714
149endocardial cushion morphogenesis (GO:0003203)2.39897834
150G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.39768738
151positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.39279871
152nucleotide transmembrane transport (GO:1901679)2.38446280
153mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.38339694
154regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.37885383
155negative regulation of axon extension (GO:0030517)2.37732555
156neuron recognition (GO:0008038)2.36796555
157developmental growth involved in morphogenesis (GO:0060560)2.36235098
158left/right pattern formation (GO:0060972)2.36182532
159regulation of glomerular filtration (GO:0003093)2.35281231
160outflow tract septum morphogenesis (GO:0003148)2.35054767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.31159004
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.74705873
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51528409
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.41592470
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.13065427
6EZH2_22144423_ChIP-Seq_EOC_Human3.03297367
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.96599748
8CLOCK_20551151_ChIP-Seq_293T_Human2.77624636
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.75176059
10CJUN_26792858_Chip-Seq_BT549_Human2.60539158
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52970264
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.52122817
13NRF2_20460467_ChIP-Seq_MEFs_Mouse2.48526373
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.48526373
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.47817960
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.44236848
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42115315
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.20886156
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17496536
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.16233250
21SOX2_20726797_ChIP-Seq_SW620_Human2.15355914
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14205950
23ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05719579
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.01371487
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97250519
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97023082
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95726686
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91471984
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81457153
30BRD4_25478319_ChIP-Seq_HGPS_Human1.80790112
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79007350
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78975250
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.77243901
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77183509
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77183509
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76513829
37TP53_18474530_ChIP-ChIP_U2OS_Human1.76512820
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.75689532
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.73856758
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71500462
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.66741319
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.66320310
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63929722
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.63185718
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60195161
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59023291
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58274557
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56469741
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54588738
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53237846
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53006911
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.52824715
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51371843
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.49033621
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47508947
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46886067
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42620552
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42255537
59* EZH2_27294783_Chip-Seq_ESCs_Mouse1.42155620
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41255009
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.41091423
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40345732
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40289167
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.39831670
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38677512
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.38610016
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37526538
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37418781
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36036502
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33621912
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31330930
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28044360
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27774810
74TP53_16413492_ChIP-PET_HCT116_Human1.27288537
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.25799262
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25054295
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22505119
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21044406
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20835914
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20766960
81MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20136946
82AHR_22903824_ChIP-Seq_MCF-7_Human1.19900102
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19897579
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19512886
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18412109
86TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18365408
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.18079515
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17979675
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17911672
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.17386599
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16894181
92* TP63_23658742_ChIP-Seq_EP156T_Human1.15150588
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15115655
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13522295
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13202380
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13183284
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12563490
98* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10958764
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.09949120
100KDM2B_26808549_Chip-Seq_K562_Human1.07946831
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06995245
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06491203
103CDX2_20551321_ChIP-Seq_CACO-2_Human1.05575915
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04750381
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04342106
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04342106
107* ISL1_27105846_Chip-Seq_CPCs_Mouse1.03616307
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03288159
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02697400
110RXR_22108803_ChIP-Seq_LS180_Human1.02343561
111* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02134822
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01408385
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01099339
114SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00514264
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00114287
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99862753
117* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99002152
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98680624
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98409653
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97761120
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97583522
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97192961
123GATA4_25053715_ChIP-Seq_YYC3_Human0.96148952
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95113321
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.94961798
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.94961798
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93740293
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.93717753
129SA1_22415368_ChIP-Seq_MEFs_Mouse0.92630507
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92018929
131* NFI_21473784_ChIP-Seq_ESCs_Mouse0.91991534
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91739090
133KLF5_25053715_ChIP-Seq_YYC3_Human0.91713484
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91611477
135EGR1_19374776_ChIP-ChIP_THP-1_Human0.91572192
136SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90277187
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.90071756
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89104275
139GBX2_23144817_ChIP-Seq_PC3_Human0.88652452
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.88378953
141TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88144100
142EZH2_27304074_Chip-Seq_ESCs_Mouse0.87353099
143VDR_24787735_ChIP-Seq_THP-1_Human0.86479591
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86353713
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86017519
146HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85742055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.70791847
2MP0005503_abnormal_tendon_morphology3.52740180
3MP0005275_abnormal_skin_tensile3.51657688
4MP0002877_abnormal_melanocyte_morpholog3.25216590
5MP0004272_abnormal_basement_membrane2.73185731
6MP0001958_emphysema2.71410016
7MP0003279_aneurysm2.63724317
8MP0009384_cardiac_valve_regurgitation2.62233658
9MP0006054_spinal_hemorrhage2.50341439
10MP0003283_abnormal_digestive_organ2.47799733
11MP0010030_abnormal_orbit_morphology2.44115249
12MP0004858_abnormal_nervous_system2.25483611
13MP0005508_abnormal_skeleton_morphology2.08765507
14MP0005257_abnormal_intraocular_pressure1.92283925
15MP0003136_yellow_coat_color1.91006123
16MP0003941_abnormal_skin_development1.90936108
17MP0000579_abnormal_nail_morphology1.90121540
18MP0005171_absent_coat_pigmentation1.89045247
19MP0009053_abnormal_anal_canal1.85423832
20MP0009250_abnormal_appendicular_skeleto1.82629735
21MP0002896_abnormal_bone_mineralization1.82459438
22MP0005248_abnormal_Harderian_gland1.82413255
23MP0003942_abnormal_urinary_system1.81570850
24MP0000678_abnormal_parathyroid_gland1.77753426
25MP0000566_synostosis1.77199642
26MP0002295_abnormal_pulmonary_circulatio1.73469072
27MP0000778_abnormal_nervous_system1.71892558
28MP0005623_abnormal_meninges_morphology1.70222443
29MP0004859_abnormal_synaptic_plasticity1.69548598
30MP0003300_gastrointestinal_ulcer1.69244714
31MP0002060_abnormal_skin_morphology1.69051390
32MP0002234_abnormal_pharynx_morphology1.66309143
33MP0009780_abnormal_chondrocyte_physiolo1.58855030
34MP0000751_myopathy1.52282977
35MP0000049_abnormal_middle_ear1.52276649
36MP0000534_abnormal_ureter_morphology1.51344977
37MP0000163_abnormal_cartilage_morphology1.50287834
38MP0001299_abnormal_eye_distance/1.48687490
39MP0003566_abnormal_cell_adhesion1.48003164
40MP0000762_abnormal_tongue_morphology1.47040402
41MP0002938_white_spotting1.43976566
42MP0003329_amyloid_beta_deposits1.43282323
43MP0003385_abnormal_body_wall1.40618830
44MP0003705_abnormal_hypodermis_morpholog1.37141040
45MP0000013_abnormal_adipose_tissue1.35907881
46MP0003938_abnormal_ear_development1.34979318
47MP0000537_abnormal_urethra_morphology1.34328272
48MP0000428_abnormal_craniofacial_morphol1.31833098
49MP0003937_abnormal_limbs/digits/tail_de1.29775917
50MP0000372_irregular_coat_pigmentation1.29105367
51MP0010386_abnormal_urinary_bladder1.28720371
52MP0005390_skeleton_phenotype1.24662780
53MP0002932_abnormal_joint_morphology1.24075055
54MP0000467_abnormal_esophagus_morphology1.23907114
55MP0001879_abnormal_lymphatic_vessel1.23127033
56MP0002653_abnormal_ependyma_morphology1.22108543
57MP0005408_hypopigmentation1.22087308
58MP0004134_abnormal_chest_morphology1.21909386
59MP0002115_abnormal_skeleton_extremities1.20405122
60MP0005023_abnormal_wound_healing1.19447070
61MP0002282_abnormal_trachea_morphology1.19046442
62MP0000733_abnormal_muscle_development1.18588018
63MP0003119_abnormal_digestive_system1.18477057
64MP0002233_abnormal_nose_morphology1.17140656
65MP0001346_abnormal_lacrimal_gland1.16891013
66MP0000462_abnormal_digestive_system1.16673012
67MP0002108_abnormal_muscle_morphology1.15770474
68MP0003091_abnormal_cell_migration1.14591125
69MP0002177_abnormal_outer_ear1.13898471
70MP0000767_abnormal_smooth_muscle1.13574798
71MP0002249_abnormal_larynx_morphology1.12544127
72MP0002113_abnormal_skeleton_development1.11930748
73MP0005076_abnormal_cell_differentiation1.11057997
74MP0003634_abnormal_glial_cell1.10775190
75MP0002098_abnormal_vibrissa_morphology1.10301631
76MP0004043_abnormal_pH_regulation1.09604504
77MP0002933_joint_inflammation1.08543401
78MP0001293_anophthalmia1.08365012
79MP0000383_abnormal_hair_follicle1.07976699
80MP0010368_abnormal_lymphatic_system1.06099655
81MP0005220_abnormal_exocrine_pancreas1.05666399
82MP0003115_abnormal_respiratory_system1.05487240
83MP0003755_abnormal_palate_morphology1.04260161
84MP0000026_abnormal_inner_ear1.04249881
85MP0003795_abnormal_bone_structure1.01236000
86MP0001984_abnormal_olfaction1.00725816
87MP0000613_abnormal_salivary_gland0.99064015
88MP0002998_abnormal_bone_remodeling0.98893942
89MP0001542_abnormal_bone_strength0.98189151
90MP0008789_abnormal_olfactory_epithelium0.98062561
91MP0002116_abnormal_craniofacial_bone0.97994354
92MP0002109_abnormal_limb_morphology0.95496114
93MP0001944_abnormal_pancreas_morphology0.94354994
94MP0003861_abnormal_nervous_system0.93555849
95MP0005595_abnormal_vascular_smooth0.92323055
96MP0010678_abnormal_skin_adnexa0.91784313
97MP0002168_other_aberrant_phenotype0.91709476
98MP0001270_distended_abdomen0.91343011
99MP0003632_abnormal_nervous_system0.89091518
100MP0009379_abnormal_foot_pigmentation0.89010831
101MP0005187_abnormal_penis_morphology0.88822670
102MP0000955_abnormal_spinal_cord0.88763239
103MP0005394_taste/olfaction_phenotype0.88249045
104MP0005499_abnormal_olfactory_system0.88249045
105MP0003935_abnormal_craniofacial_develop0.87692009
106MP0005058_abnormal_lysosome_morphology0.86321101
107MP0000432_abnormal_head_morphology0.85630926
108MP0001243_abnormal_dermal_layer0.84287651
109MP0002089_abnormal_postnatal_growth/wei0.83731299
110MP0002111_abnormal_tail_morphology0.80679745
111MP0001533_abnormal_skeleton_physiology0.80431967
112MP0002133_abnormal_respiratory_system0.79878193
113MP0005388_respiratory_system_phenotype0.79878193
114MP0001286_abnormal_eye_development0.78862153
115MP0001177_atelectasis0.77635667
116MP0003122_maternal_imprinting0.77362078
117MP0001849_ear_inflammation0.75776315
118MP0000516_abnormal_urinary_system0.75197896
119MP0005367_renal/urinary_system_phenotyp0.75197896
120* MP0002084_abnormal_developmental_patter0.74961275
121MP0004133_heterotaxia0.73004693
122MP0002697_abnormal_eye_size0.72763158
123MP0005197_abnormal_uvea_morphology0.72422496
124MP0000003_abnormal_adipose_tissue0.72358214
125MP0002009_preneoplasia0.72292170
126MP0002152_abnormal_brain_morphology0.71053817
127MP0000538_abnormal_urinary_bladder0.70275561
128MP0002114_abnormal_axial_skeleton0.69284671
129MP0001915_intracranial_hemorrhage0.68900141
130MP0000750_abnormal_muscle_regeneration0.68648448
131MP0002254_reproductive_system_inflammat0.68548278
132MP0002928_abnormal_bile_duct0.67569916
133MP0002734_abnormal_mechanical_nocicepti0.67277166
134MP0002092_abnormal_eye_morphology0.67251941
135MP0001614_abnormal_blood_vessel0.66344925
136* MP0002085_abnormal_embryonic_tissue0.64207700

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.83158406
2Protrusio acetabuli (HP:0003179)4.98279273
3Aortic dissection (HP:0002647)3.91511784
4Atrophic scars (HP:0001075)3.86806956
5Soft skin (HP:0000977)3.56849518
6Aortic aneurysm (HP:0004942)3.44858521
7Vascular tortuosity (HP:0004948)3.34011743
8Abnormality of dentin (HP:0010299)3.29923189
9Shallow orbits (HP:0000586)3.26194058
10Coronal craniosynostosis (HP:0004440)3.25036891
11Ankle contracture (HP:0006466)3.25011523
12Cervical subluxation (HP:0003308)3.24168132
13Fragile skin (HP:0001030)3.10545397
14Arterial tortuosity (HP:0005116)3.05365036
15Thin bony cortex (HP:0002753)3.02539249
16Turricephaly (HP:0000262)2.99709212
17Wormian bones (HP:0002645)2.93711577
18Bronchomalacia (HP:0002780)2.93665300
19Femoral bowing (HP:0002980)2.87510221
20Neonatal short-limb short stature (HP:0008921)2.85446082
21Split foot (HP:0001839)2.83039176
22Broad metatarsal (HP:0001783)2.67429695
23Cerebral aneurysm (HP:0004944)2.66136124
24Spondylolisthesis (HP:0003302)2.64068958
25Blue sclerae (HP:0000592)2.63076095
26Follicular hyperkeratosis (HP:0007502)2.60061458
27Bladder diverticulum (HP:0000015)2.59810889
28Dilatation of the ascending aorta (HP:0005111)2.58553384
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.56631854
30Mesomelia (HP:0003027)2.56215395
31Vertebral compression fractures (HP:0002953)2.48567448
32Abnormality of the distal phalanges of the toes (HP:0010182)2.47988254
33Morphological abnormality of the middle ear (HP:0008609)2.46767240
34Partial duplication of thumb phalanx (HP:0009944)2.42161423
35Spinal rigidity (HP:0003306)2.40467061
36Partial duplication of the phalanx of hand (HP:0009999)2.39649859
37Peritonitis (HP:0002586)2.37695178
38Short nail (HP:0001799)2.36128600
39Genu recurvatum (HP:0002816)2.31052302
40Pterygium (HP:0001059)2.31028720
41Tibial bowing (HP:0002982)2.30993859
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28769150
43Vitreoretinal degeneration (HP:0000655)2.27167606
44Arnold-Chiari malformation (HP:0002308)2.24535135
45Cutaneous finger syndactyly (HP:0010554)2.22069095
46Osteolytic defects of the hand bones (HP:0009699)2.19682032
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.19682032
48Dysostosis multiplex (HP:0000943)2.18111446
49Broad face (HP:0000283)2.15007184
50Tarsal synostosis (HP:0008368)2.14887916
51Abnormal respiratory motile cilium physiology (HP:0012261)2.12320189
52Thin ribs (HP:0000883)2.11604624
53Abnormal ciliary motility (HP:0012262)2.08842492
54Scapular winging (HP:0003691)2.08451257
55Neurofibrillary tangles (HP:0002185)2.07858315
56Epiphyseal dysplasia (HP:0002656)2.07140178
57Bell-shaped thorax (HP:0001591)2.06444906
58Cutaneous syndactyly (HP:0012725)2.05974180
59Pulmonary artery stenosis (HP:0004415)2.02621198
60Trigonocephaly (HP:0000243)2.01388791
61Abnormality of the middle phalanges of the toes (HP:0010183)1.97388992
62Absent frontal sinuses (HP:0002688)1.96027258
63Synostosis involving bones of the lower limbs (HP:0009138)1.95512056
64Synostosis involving bones of the feet (HP:0009140)1.95512056
65Platyspondyly (HP:0000926)1.94394965
66Obstructive sleep apnea (HP:0002870)1.93840857
67Megalencephaly (HP:0001355)1.93821645
68Aplasia involving bones of the upper limbs (HP:0009823)1.93252677
69Aplasia of the phalanges of the hand (HP:0009802)1.93252677
70Aplasia involving bones of the extremities (HP:0009825)1.93252677
71Stridor (HP:0010307)1.92615785
72Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91510328
73Abnormal respiratory epithelium morphology (HP:0012253)1.90434069
74Abnormal respiratory motile cilium morphology (HP:0005938)1.90434069
75Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89608828
76Tracheomalacia (HP:0002779)1.89144862
77Ulnar bowing (HP:0003031)1.89045627
78Abnormality of the acetabulum (HP:0003170)1.88542466
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.88448436
80Broad ribs (HP:0000885)1.88230213
81Spinal cord lesions (HP:0100561)1.87337953
82Syringomyelia (HP:0003396)1.87337953
83Generalized aminoaciduria (HP:0002909)1.87305532
84Short middle phalanx of the 5th finger (HP:0004220)1.87210270
85Hyperextensible skin (HP:0000974)1.86700113
86Rhinitis (HP:0012384)1.86503025
87Mitral regurgitation (HP:0001653)1.85257457
88Hypoventilation (HP:0002791)1.84558912
89Preaxial foot polydactyly (HP:0001841)1.83874379
90Natal tooth (HP:0000695)1.83422652
91Hypoplasia of the iris (HP:0007676)1.83159042
92Occipital encephalocele (HP:0002085)1.82920369
93Urinary glycosaminoglycan excretion (HP:0003541)1.82883462
94Mucopolysacchariduria (HP:0008155)1.82883462
95Broad distal phalanx of finger (HP:0009836)1.82337761
96Overriding aorta (HP:0002623)1.82251698
97Broad long bones (HP:0005622)1.80965455
98Increased connective tissue (HP:0009025)1.80791566
99Type 1 muscle fiber predominance (HP:0003803)1.79824391
100Enlarged epiphyses (HP:0010580)1.79764596
101Increased variability in muscle fiber diameter (HP:0003557)1.79516197
102Nuclear cataract (HP:0100018)1.78798564
103Mitral valve prolapse (HP:0001634)1.78686041
104Abnormality of the ischium (HP:0003174)1.77544040
105Congenital glaucoma (HP:0001087)1.77378994
106Abnormality of the frontal sinuses (HP:0002687)1.77282565
107Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.77177362
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77054445
109Short 4th metacarpal (HP:0010044)1.77054445
110Biconcave vertebral bodies (HP:0004586)1.76372364
111Bowing of the arm (HP:0006488)1.76308290
112Bowed forearm bones (HP:0003956)1.76308290
113Abnormality of the 2nd finger (HP:0004100)1.76072638
114Vertebral arch anomaly (HP:0008438)1.75884625
115Joint laxity (HP:0001388)1.75555755
116Aortic regurgitation (HP:0001659)1.74717624
117Beaking of vertebral bodies (HP:0004568)1.74432252
118Buphthalmos (HP:0000557)1.74319988
119Wide anterior fontanel (HP:0000260)1.74145239
120Renal duplication (HP:0000075)1.73952031
121Hypoplastic labia majora (HP:0000059)1.73492068
122Craniofacial hyperostosis (HP:0004493)1.73488819
123Large earlobe (HP:0009748)1.73112447
124Asymmetry of the thorax (HP:0001555)1.73054088
125Short hallux (HP:0010109)1.72689265
126Persistence of primary teeth (HP:0006335)1.72586378
127Synostosis of carpal bones (HP:0005048)1.72530842
128Hallux valgus (HP:0001822)1.71324141
129Osteoarthritis (HP:0002758)1.71250245
130Abnormality of carpal bone ossification (HP:0006257)1.70749201
131Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.70513037
132Vertebral hypoplasia (HP:0008417)1.70513037
133Cupped ribs (HP:0000887)1.69139044
134Limb-girdle muscle weakness (HP:0003325)1.69131623
135Overgrowth (HP:0001548)1.68916141
136Exostoses (HP:0100777)1.68878683
137Broad toe (HP:0001837)1.68407029
138Thoracolumbar scoliosis (HP:0002944)1.68297037
139Bowel diverticulosis (HP:0005222)1.68138293
140Hypoplasia of the odontoid process (HP:0003311)1.67226120
141Hypokalemia (HP:0002900)1.66964210
142Mildly elevated creatine phosphokinase (HP:0008180)1.66528180
143Bifid tongue (HP:0010297)1.65897758
144Deviation of the hallux (HP:0010051)1.65102663
145Aplasia/Hypoplasia of the hallux (HP:0008362)1.64294173
146Abnormality of the labia majora (HP:0012881)1.64162823
147Vacuolated lymphocytes (HP:0001922)1.63905292
148Abnormal vertebral ossification (HP:0100569)1.63670099
149Elbow flexion contracture (HP:0002987)1.63573719
150Camptodactyly of toe (HP:0001836)1.63299277
151Absent/shortened dynein arms (HP:0200106)1.62118701
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.62118701
153Broad hallux (HP:0010055)1.61989678
154Alacrima (HP:0000522)1.61939720
155Limited hip movement (HP:0008800)1.61691186
156Abnormality of the anterior chamber (HP:0000593)1.60977866
157Broad thumb (HP:0011304)1.60024531
158Atelectasis (HP:0100750)1.59855121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR23.16753092
2MAPK152.87575086
3FRK2.70859969
4PASK2.70310632
5EPHB22.67860675
6LATS22.47418534
7MARK12.42845483
8LATS12.40683337
9TTN2.37430959
10INSRR2.33531144
11PDGFRA2.32511329
12PNCK2.31440705
13TGFBR22.30868850
14NTRK22.17812971
15WNK42.13249897
16ERBB32.06247343
17CASK2.05809754
18TRPM71.98955996
19MET1.86787024
20STK391.76609501
21EPHB11.71702608
22EPHA41.62630851
23LMTK21.60564354
24PAK31.60346511
25EPHA31.59917515
26MAP3K21.58961252
27SIK11.58120827
28MAPKAPK51.57173085
29PAK21.53641375
30ERN11.53420708
31TNIK1.50789403
32FER1.46296313
33LIMK11.43135289
34PTK61.39217117
35PIK3CA1.36570648
36TRIB31.35857044
37MYLK1.33811164
38PIK3CG1.31909941
39MST41.28702081
40PAK61.28207304
41HIPK21.26855088
42PTK21.24780687
43MAP3K31.20497025
44ZAK1.20386588
45TESK11.19989329
46PRKD31.19301348
47NTRK11.15339955
48PDGFRB1.14458277
49ERBB41.14391379
50LRRK21.13438218
51PAK41.13314185
52STK31.12791357
53STK38L1.12702406
54TYRO31.09370522
55EPHA21.08440718
56OXSR11.08428662
57TGFBR11.07607156
58ICK1.05341948
59NUAK11.04925149
60FGFR21.04430541
61KSR11.03536016
62BCR0.99944627
63GRK70.93870140
64NEK60.93246250
65CSNK1G20.91215143
66NEK90.91067812
67DMPK0.89890894
68BMPR1B0.87226278
69TIE10.85622025
70ARAF0.84306283
71WNK10.84277606
72PLK20.84104744
73RPS6KA40.82722603
74FGFR10.82597066
75MOS0.80329101
76ROCK10.80122412
77ROCK20.79884829
78PBK0.79394337
79MAP2K70.77112632
80CSNK1G30.76452722
81ILK0.75395133
82PIM20.74278241
83NTRK30.72805059
84PRKCE0.72697716
85DYRK1B0.72565414
86CSNK1G10.69790584
87CAMK1G0.69604572
88MAP3K40.68001240
89FLT30.67961134
90RPS6KA20.65955179
91STK380.65658077
92KSR20.65558898
93CSNK1A1L0.62441442
94MST1R0.60872608
95MKNK10.60543198
96ERBB20.60459896
97CDK80.60265066
98GSK3A0.59505074
99CDK140.59335180
100MAPKAPK20.59316306
101CHUK0.57629803
102IRAK10.57597419
103ADRBK10.57593829
104RIPK10.57517699
105CDK180.56057145
106CDK150.55855702
107CDC42BPA0.55207913
108IGF1R0.54297705
109INSR0.53653642
110RET0.53428496
111IKBKB0.52652539
112AKT20.51425917
113CDK11A0.51335595
114JAK10.51298033
115MTOR0.50297645
116UHMK10.50258678
117PRKD10.49558329
118CDK50.48765238
119GRK50.48671023
120CAMKK20.47592419
121TEC0.47167785
122MAP3K60.46805269
123BTK0.45781338
124PRKG20.44798782
125ITK0.44758799
126STK240.44269450
127CDK120.43209637
128BMX0.42509346
129SRC0.41989613
130MAP2K10.41458749
131JAK30.41375991
132CAMK2G0.40400841
133EIF2AK30.40247656
134MAP2K20.40026268
135PRKD20.39374809
136PKN20.38941422
137PTK2B0.38897576
138DYRK1A0.38892931
139MAP3K100.38026407
140CDK60.38014452
141CLK10.37968456
142CAMK2D0.37875943
143CAMK2B0.37381095
144NLK0.36749952
145PRKCH0.36296413
146DYRK30.35574296
147MAPK100.35003480
148MAP2K40.33762225
149MAPK70.30938879
150PRKCG0.30356529

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.33645968
2ECM-receptor interaction_Homo sapiens_hsa045123.11435819
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.78634715
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.47240844
5Sulfur metabolism_Homo sapiens_hsa009202.33447627
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.18730179
7Focal adhesion_Homo sapiens_hsa045102.13837571
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.99975274
9N-Glycan biosynthesis_Homo sapiens_hsa005101.93256675
10Other glycan degradation_Homo sapiens_hsa005111.86457398
11Basal cell carcinoma_Homo sapiens_hsa052171.85628311
12Protein digestion and absorption_Homo sapiens_hsa049741.73337510
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64467399
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62846132
15Proteoglycans in cancer_Homo sapiens_hsa052051.62553655
16Lysosome_Homo sapiens_hsa041421.62008001
17Hippo signaling pathway_Homo sapiens_hsa043901.60026865
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53985719
19Hedgehog signaling pathway_Homo sapiens_hsa043401.53881831
20TGF-beta signaling pathway_Homo sapiens_hsa043501.52648940
21Adherens junction_Homo sapiens_hsa045201.51087704
22Malaria_Homo sapiens_hsa051441.50070393
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42847342
24Gap junction_Homo sapiens_hsa045401.38934779
25Vibrio cholerae infection_Homo sapiens_hsa051101.38374316
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37615999
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37279364
28Amoebiasis_Homo sapiens_hsa051461.36550095
29Small cell lung cancer_Homo sapiens_hsa052221.32374719
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32108716
31Sphingolipid metabolism_Homo sapiens_hsa006001.27215322
32Prion diseases_Homo sapiens_hsa050201.24521882
33Prostate cancer_Homo sapiens_hsa052151.24333131
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.23856535
35Bladder cancer_Homo sapiens_hsa052191.23034768
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.22723296
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22206834
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.20994865
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18698596
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15976135
41Phagosome_Homo sapiens_hsa041451.13639069
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09858850
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02800904
44Tight junction_Homo sapiens_hsa045301.02244459
45MicroRNAs in cancer_Homo sapiens_hsa052061.01807773
46Dilated cardiomyopathy_Homo sapiens_hsa054141.01070619
47Chronic myeloid leukemia_Homo sapiens_hsa052200.99487255
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96096297
49Steroid biosynthesis_Homo sapiens_hsa001000.95997592
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95700335
51Arachidonic acid metabolism_Homo sapiens_hsa005900.94621467
52Rheumatoid arthritis_Homo sapiens_hsa053230.92794751
53Estrogen signaling pathway_Homo sapiens_hsa049150.92278804
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91671152
55Thyroid cancer_Homo sapiens_hsa052160.91493025
56Thyroid hormone synthesis_Homo sapiens_hsa049180.88838847
57Glioma_Homo sapiens_hsa052140.87743700
58Melanoma_Homo sapiens_hsa052180.87127043
59Axon guidance_Homo sapiens_hsa043600.86423145
60TNF signaling pathway_Homo sapiens_hsa046680.86249303
61Pathways in cancer_Homo sapiens_hsa052000.85977498
62Wnt signaling pathway_Homo sapiens_hsa043100.82953832
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81321324
64Toxoplasmosis_Homo sapiens_hsa051450.80457208
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79611092
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79247613
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77154502
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.75149507
69Leishmaniasis_Homo sapiens_hsa051400.73527642
70Platelet activation_Homo sapiens_hsa046110.73186725
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.72938909
72Pancreatic cancer_Homo sapiens_hsa052120.72798742
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72694220
74Glutathione metabolism_Homo sapiens_hsa004800.72616708
75Colorectal cancer_Homo sapiens_hsa052100.71949716
76ErbB signaling pathway_Homo sapiens_hsa040120.71753323
77Melanogenesis_Homo sapiens_hsa049160.71276928
78Shigellosis_Homo sapiens_hsa051310.69715615
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68942426
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68711450
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68148023
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67214319
83Notch signaling pathway_Homo sapiens_hsa043300.67109815
84Ether lipid metabolism_Homo sapiens_hsa005650.66768331
85HTLV-I infection_Homo sapiens_hsa051660.62539497
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61624029
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61365328
88Mineral absorption_Homo sapiens_hsa049780.61179723
89Choline metabolism in cancer_Homo sapiens_hsa052310.60490045
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60367006
91Legionellosis_Homo sapiens_hsa051340.58670942
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57670987
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56925864
94PPAR signaling pathway_Homo sapiens_hsa033200.55134563
95Bile secretion_Homo sapiens_hsa049760.54687841
96Pertussis_Homo sapiens_hsa051330.54046166
97AMPK signaling pathway_Homo sapiens_hsa041520.53957627
98Gastric acid secretion_Homo sapiens_hsa049710.53939360
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53340296
100cAMP signaling pathway_Homo sapiens_hsa040240.52764033
101Circadian rhythm_Homo sapiens_hsa047100.52710360
102Renal cell carcinoma_Homo sapiens_hsa052110.52623540
103Salmonella infection_Homo sapiens_hsa051320.52482355
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52175625
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52096138
106Ovarian steroidogenesis_Homo sapiens_hsa049130.50957928
107Apoptosis_Homo sapiens_hsa042100.49761281
108GnRH signaling pathway_Homo sapiens_hsa049120.49701963
109Dopaminergic synapse_Homo sapiens_hsa047280.49522949
110Insulin secretion_Homo sapiens_hsa049110.48863632
111Rap1 signaling pathway_Homo sapiens_hsa040150.48794918
112Circadian entrainment_Homo sapiens_hsa047130.46719721
113GABAergic synapse_Homo sapiens_hsa047270.45482402
114Renin-angiotensin system_Homo sapiens_hsa046140.45288473
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45246596
116Antigen processing and presentation_Homo sapiens_hsa046120.43952413
117Prolactin signaling pathway_Homo sapiens_hsa049170.43626552
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43291112
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43047617
120Fatty acid elongation_Homo sapiens_hsa000620.42578036
121Endometrial cancer_Homo sapiens_hsa052130.42150953
122p53 signaling pathway_Homo sapiens_hsa041150.40731004
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40724959
124Glutamatergic synapse_Homo sapiens_hsa047240.40135417
125Cholinergic synapse_Homo sapiens_hsa047250.39570994
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39336959
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38115186
128Osteoclast differentiation_Homo sapiens_hsa043800.37910852
129Endocytosis_Homo sapiens_hsa041440.37484805
130Insulin signaling pathway_Homo sapiens_hsa049100.37448908
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37293641
132Ras signaling pathway_Homo sapiens_hsa040140.37207015
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.37143445
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36998679
135Cocaine addiction_Homo sapiens_hsa050300.36762587
136Hepatitis B_Homo sapiens_hsa051610.36755743
137Biosynthesis of amino acids_Homo sapiens_hsa012300.36737712
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36001821
139Renin secretion_Homo sapiens_hsa049240.35835106
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35768149
141VEGF signaling pathway_Homo sapiens_hsa043700.34901803
142Lysine degradation_Homo sapiens_hsa003100.33024098
143Synaptic vesicle cycle_Homo sapiens_hsa047210.32317892
144Long-term depression_Homo sapiens_hsa047300.30926598

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