WNK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.55796899
2central nervous system myelination (GO:0022010)4.55796899
3cytoplasmic mRNA processing body assembly (GO:0033962)4.48891345
4ensheathment of neurons (GO:0007272)3.73327770
5axon ensheathment (GO:0008366)3.73327770
6regulation of NFAT protein import into nucleus (GO:0051532)3.68934690
7myelination (GO:0042552)3.67869433
8histone H3-K9 demethylation (GO:0033169)3.54078900
9protein localization to endosome (GO:0036010)3.33638802
10glucocorticoid receptor signaling pathway (GO:0042921)3.33164484
11regulation of ARF protein signal transduction (GO:0032012)3.27802599
12regulation of histone H3-K27 methylation (GO:0061085)3.23715005
13positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.22384792
14regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.22384792
15myelin maintenance (GO:0043217)3.13376416
16corticosteroid receptor signaling pathway (GO:0031958)3.07472040
17positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.03394197
18regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.03394197
19histone H3-K4 trimethylation (GO:0080182)3.03263495
20negative regulation of neurotransmitter secretion (GO:0046929)3.02555201
21negative regulation of erythrocyte differentiation (GO:0045647)3.00779882
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.00579727
23growth hormone receptor signaling pathway (GO:0060396)2.99187851
24negative regulation of myotube differentiation (GO:0010832)2.94107985
25* peptidyl-threonine phosphorylation (GO:0018107)2.92905604
26histone demethylation (GO:0016577)2.89575705
27regulation of RNA export from nucleus (GO:0046831)2.88505693
28asymmetric protein localization (GO:0008105)2.88407167
29response to lipoprotein particle (GO:0055094)2.86375392
30nuclear pore organization (GO:0006999)2.85750296
31embryonic camera-type eye morphogenesis (GO:0048596)2.85720035
32peripheral nervous system axon ensheathment (GO:0032292)2.85665110
33myelination in peripheral nervous system (GO:0022011)2.85665110
34peptidyl-tyrosine autophosphorylation (GO:0038083)2.85000018
35creatine metabolic process (GO:0006600)2.83778433
36establishment of nucleus localization (GO:0040023)2.83737644
37negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.82136474
38embryonic process involved in female pregnancy (GO:0060136)2.80834769
39protoporphyrinogen IX metabolic process (GO:0046501)2.77341832
40cell-substrate adherens junction assembly (GO:0007045)2.75355732
41focal adhesion assembly (GO:0048041)2.75355732
42* peptidyl-threonine modification (GO:0018210)2.75206306
43cytoskeletal anchoring at plasma membrane (GO:0007016)2.73583585
44astrocyte development (GO:0014002)2.73006113
45gas transport (GO:0015669)2.72402509
46regulation of nucleobase-containing compound transport (GO:0032239)2.71424793
47negative regulation of translation, ncRNA-mediated (GO:0040033)2.71359814
48regulation of translation, ncRNA-mediated (GO:0045974)2.71359814
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71359814
50positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.70227048
51regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.70067806
52cellular response to epinephrine stimulus (GO:0071872)2.69633397
53cortical actin cytoskeleton organization (GO:0030866)2.66847875
54nerve growth factor signaling pathway (GO:0038180)2.65745802
55cellular response to growth hormone stimulus (GO:0071378)2.64909016
56adherens junction assembly (GO:0034333)2.62931456
57cell-substrate junction assembly (GO:0007044)2.62788403
58nucleus localization (GO:0051647)2.62009939
59pre-miRNA processing (GO:0031054)2.61877124
60erythrocyte development (GO:0048821)2.60058715
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58580371
62oxygen transport (GO:0015671)2.58338347
63positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.56417618
64insulin-like growth factor receptor signaling pathway (GO:0048009)2.56005436
65pore complex assembly (GO:0046931)2.55161174
66protein targeting to plasma membrane (GO:0072661)2.53524588
67positive regulation of receptor recycling (GO:0001921)2.53377791
68negative regulation of histone methylation (GO:0031061)2.53200673
69monoubiquitinated protein deubiquitination (GO:0035520)2.52638188
70platelet-derived growth factor receptor signaling pathway (GO:0048008)2.51307194
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47901024
72negative regulation of protein localization to cell surface (GO:2000009)2.47256891
73protein demethylation (GO:0006482)2.47126519
74protein dealkylation (GO:0008214)2.47126519
75regulation of response to osmotic stress (GO:0047484)2.47067780
76cerebellar granule cell differentiation (GO:0021707)2.46865135
77membrane raft organization (GO:0031579)2.46207008
78regulation of protein polyubiquitination (GO:1902914)2.46078788
79regulation of Rap GTPase activity (GO:0032317)2.45989698
80N-terminal protein amino acid acetylation (GO:0006474)2.45852633
81positive T cell selection (GO:0043368)2.44580710
82cerebellar Purkinje cell differentiation (GO:0021702)2.43177082
83positive regulation of mRNA catabolic process (GO:0061014)2.41662778
84definitive hemopoiesis (GO:0060216)2.41632423
85Golgi to endosome transport (GO:0006895)2.41557234
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.40915082
87cortical cytoskeleton organization (GO:0030865)2.40492314
88mesodermal cell differentiation (GO:0048333)2.39784236
89regulation of mRNA 3-end processing (GO:0031440)2.39553091
90import into cell (GO:0098657)2.39448608
91cellular response to catecholamine stimulus (GO:0071870)2.39166663
92cellular response to monoamine stimulus (GO:0071868)2.39166663
93histone lysine methylation (GO:0034968)2.39162569
94negative regulation of DNA repair (GO:0045738)2.37812066
95positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37690407
96photoreceptor cell differentiation (GO:0046530)2.37483197
97eye photoreceptor cell differentiation (GO:0001754)2.37483197
98hemoglobin metabolic process (GO:0020027)2.35939282
99positive regulation of macroautophagy (GO:0016239)2.34684997
100iron ion import (GO:0097286)2.33437714
101glomerular filtration (GO:0003094)2.32499709
102coronary vasculature morphogenesis (GO:0060977)2.32349537
103peptidyl-serine phosphorylation (GO:0018105)2.32333942
104renal filtration (GO:0097205)2.31229491
105regulation of mRNA catabolic process (GO:0061013)2.30772679
106cardiac myofibril assembly (GO:0055003)2.30726773
107myofibril assembly (GO:0030239)2.29617458
108establishment of spindle orientation (GO:0051294)2.29325060
109negative regulation of potassium ion transmembrane transport (GO:1901380)2.28657632
110embryonic eye morphogenesis (GO:0048048)2.28038592
111apical protein localization (GO:0045176)2.27643570
112positive regulation of mRNA 3-end processing (GO:0031442)2.27389215
113virion attachment to host cell (GO:0019062)2.26881471
114adhesion of symbiont to host cell (GO:0044650)2.26881471
115histone H3-K36 demethylation (GO:0070544)2.26833960
116dosage compensation (GO:0007549)2.26331782
117regulation of necroptotic process (GO:0060544)2.25925195
118fibroblast migration (GO:0010761)2.23222191
119histone H3-K4 methylation (GO:0051568)2.22772624
120negative regulation of vascular permeability (GO:0043116)2.22643983
121mitotic sister chromatid cohesion (GO:0007064)2.20784812
122cellular hyperosmotic response (GO:0071474)2.20691074
123sodium ion export (GO:0071436)2.18605589
124retrograde transport, vesicle recycling within Golgi (GO:0000301)2.18539962
125cell communication by electrical coupling (GO:0010644)2.18235943
126regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.17994175
127response to epidermal growth factor (GO:0070849)2.17956447
128protein export from nucleus (GO:0006611)2.17621051
129positive regulation of cellular response to insulin stimulus (GO:1900078)2.17578544
130negative regulation of neurotransmitter transport (GO:0051589)2.17541773
131establishment of spindle localization (GO:0051293)2.17079463
132negative regulation of inclusion body assembly (GO:0090084)2.16520945
133NLS-bearing protein import into nucleus (GO:0006607)2.15318894
134response to epinephrine (GO:0071871)2.14893292
135synaptic vesicle docking involved in exocytosis (GO:0016081)2.14840290
136thymic T cell selection (GO:0045061)2.14306029
137regulation of T cell tolerance induction (GO:0002664)2.14173823
1383-UTR-mediated mRNA stabilization (GO:0070935)2.13696671
139protein targeting to Golgi (GO:0000042)2.13225065
140cardiac muscle hypertrophy (GO:0003300)2.13064605
141positive regulation of gamma-delta T cell activation (GO:0046645)2.11708650
142negative regulation of striated muscle cell differentiation (GO:0051154)2.11569236
143peptidyl-lysine trimethylation (GO:0018023)2.10979661
144long-chain fatty acid biosynthetic process (GO:0042759)2.10606051
145heart morphogenesis (GO:0003007)2.08306055
146activated T cell proliferation (GO:0050798)2.07607072
147membrane tubulation (GO:0097320)2.05758091
148retina vasculature morphogenesis in camera-type eye (GO:0061299)2.05735893
149sarcomere organization (GO:0045214)2.05222351
150establishment of protein localization to Golgi (GO:0072600)2.04275336
151negative regulation of Rho protein signal transduction (GO:0035024)2.03811136
152regulation of interleukin-12 biosynthetic process (GO:0045075)2.01769213
153Rap protein signal transduction (GO:0032486)1.98595034
154nuclear pore complex assembly (GO:0051292)1.97638134
155interkinetic nuclear migration (GO:0022027)1.97563263
156negative regulation of T-helper cell differentiation (GO:0045623)1.97189621
157negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)1.97189621
158centrosome duplication (GO:0051298)1.97018580
159positive regulation of histone deacetylation (GO:0031065)1.96624549
160positive regulation of glial cell differentiation (GO:0045687)1.96479468
161positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.96434168
162histone lysine demethylation (GO:0070076)1.93620933
163plasma membrane repair (GO:0001778)1.93336534
164interleukin-6-mediated signaling pathway (GO:0070102)1.92486893
165positive regulation of Rap GTPase activity (GO:0032854)1.92436049
166positive thymic T cell selection (GO:0045059)1.92226690
167positive regulation of gliogenesis (GO:0014015)1.91989458
168glomerular basement membrane development (GO:0032836)1.91554775
169histone H3-K9 modification (GO:0061647)1.91533361
170positive regulation of oligodendrocyte differentiation (GO:0048714)1.91409225
171Leydig cell differentiation (GO:0033327)1.90685363
172face morphogenesis (GO:0060325)1.90670320
173negative regulation of peptidyl-threonine phosphorylation (GO:0010801)1.87756598
174negative thymic T cell selection (GO:0045060)1.87470542
175regulation of p38MAPK cascade (GO:1900744)1.87469093
176cellular response to nerve growth factor stimulus (GO:1990090)1.87328750
177response to nerve growth factor (GO:1990089)1.87328750
178negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.86840449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.92267586
2GATA1_22025678_ChIP-Seq_K562_Human3.06406261
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55367705
4VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43971792
5MYC_22102868_ChIP-Seq_BL_Human2.31545595
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.19886697
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19320877
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14055697
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10117936
10CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95962573
11E2F7_22180533_ChIP-Seq_HELA_Human1.90043480
12STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86849404
13EP300_21415370_ChIP-Seq_HL-1_Mouse1.83057928
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80948872
15TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77078923
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75658593
17FOXM1_23109430_ChIP-Seq_U2OS_Human1.74266944
18TP53_16413492_ChIP-PET_HCT116_Human1.70076396
19RUNX_20019798_ChIP-Seq_JUKART_Human1.69702292
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.68216968
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.67363550
22GATA1_19941827_ChIP-Seq_MEL_Mouse1.66792335
23GATA2_19941826_ChIP-Seq_K562_Human1.63351401
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62654247
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62547243
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57951457
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57011343
28NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51422271
29CLOCK_20551151_ChIP-Seq_293T_Human1.50464012
30AHR_22903824_ChIP-Seq_MCF-7_Human1.50363383
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.46155420
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.43938568
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41300699
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41049825
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40885484
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40547213
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36851728
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.36019783
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33177379
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32376741
41VDR_24787735_ChIP-Seq_THP-1_Human1.31875586
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31642338
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.31318171
44CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31098696
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.28673753
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28287388
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27646118
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27504419
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26389648
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.24928064
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.24928064
52ISL1_27105846_Chip-Seq_CPCs_Mouse1.24920689
53* KDM2B_26808549_Chip-Seq_DND41_Human1.24877659
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22731985
55AR_21572438_ChIP-Seq_LNCaP_Human1.22048246
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21014205
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20972133
58STAT3_23295773_ChIP-Seq_U87_Human1.20086883
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19952483
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19671434
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19598741
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.18468516
63DROSHA_22980978_ChIP-Seq_HELA_Human1.18423915
64* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17811124
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17232730
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16378814
67* CJUN_26792858_Chip-Seq_BT549_Human1.14190826
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14067998
69* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13649578
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13450870
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11673275
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.11431824
73* VDR_21846776_ChIP-Seq_THP-1_Human1.11048040
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.10984835
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10179048
76GATA1_19941826_ChIP-Seq_K562_Human1.09876805
77* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09569881
78* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08455710
79GATA1_19941827_ChIP-Seq_MEL86_Mouse1.08415465
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08045513
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07803709
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07596516
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06857001
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.06814545
85* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06392521
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06392392
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.06110771
88* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05967448
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.05648375
90TBL1_22424771_ChIP-Seq_293T_Human1.05429390
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05353746
92* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05003621
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04714676
94* TCF4_23295773_ChIP-Seq_U87_Human1.04638633
95* ELK3_25401928_ChIP-Seq_HUVEC_Human1.04276360
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03394127
97* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03348550
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03230821
99* MAF_26560356_Chip-Seq_TH1_Human1.03170309
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03101043
101* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02839867
102* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02407864
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.02372829
104GBX2_23144817_ChIP-Seq_PC3_Human1.01706964
105* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00619546
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00424261
107ER_23166858_ChIP-Seq_MCF-7_Human0.99873188
108KDM2B_26808549_Chip-Seq_K562_Human0.99349867
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99242383
110SPI1_23127762_ChIP-Seq_K562_Human0.98710946
111* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97698792
112FOXA2_19822575_ChIP-Seq_HepG2_Human0.96466811
113* TCF7_22412390_ChIP-Seq_EML_Mouse0.95638227
114* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95521241
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95213294
116SCL_19346495_ChIP-Seq_HPC-7_Human0.94876566
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94839744
118* RACK7_27058665_Chip-Seq_MCF-7_Human0.94615949
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.93823336
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93496509
121* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93348284
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92869812
123* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92794805
124SMAD4_21799915_ChIP-Seq_A2780_Human0.91882246
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91842614
126TP63_23658742_ChIP-Seq_EP156T_Human0.91662063
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91587203
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91315758
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89977349
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88943177
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88021021
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88001376
133FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87553350
134BRD4_25478319_ChIP-Seq_HGPS_Human0.87404220
135TP63_17297297_ChIP-ChIP_HaCaT_Human0.85251468
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85155923
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85155923
138RXR_22108803_ChIP-Seq_LS180_Human0.85121185
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84650575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo3.48536186
2MP0003705_abnormal_hypodermis_morpholog3.32805805
3MP0003950_abnormal_plasma_membrane3.31273160
4MP0005623_abnormal_meninges_morphology3.08689715
5MP0000920_abnormal_myelination3.00995543
6MP0005451_abnormal_body_composition2.51657281
7MP0000569_abnormal_digit_pigmentation2.32541438
8MP0000383_abnormal_hair_follicle2.31606391
9MP0010678_abnormal_skin_adnexa2.25250396
10MP0003300_gastrointestinal_ulcer2.21025151
11MP0000733_abnormal_muscle_development2.17166047
12MP0004084_abnormal_cardiac_muscle2.14887656
13MP0008260_abnormal_autophagy2.11549374
14MP0002009_preneoplasia2.08086472
15MP0003045_fibrosis2.02935559
16MP0004510_myositis2.01745484
17MP0003091_abnormal_cell_migration1.96569757
18MP0004130_abnormal_muscle_cell1.94018113
19MP0004185_abnormal_adipocyte_glucose1.91845106
20MP0003763_abnormal_thymus_physiology1.91104943
21MP0004808_abnormal_hematopoietic_stem1.87961628
22MP0005275_abnormal_skin_tensile1.84156363
23MP0002166_altered_tumor_susceptibility1.78781218
24MP0004381_abnormal_hair_follicle1.78168971
25MP0002396_abnormal_hematopoietic_system1.76159837
26MP0004036_abnormal_muscle_relaxation1.73940433
27MP0003690_abnormal_glial_cell1.73831964
28MP0001299_abnormal_eye_distance/1.73335098
29MP0005076_abnormal_cell_differentiation1.71903889
30MP0004233_abnormal_muscle_weight1.65751142
31MP0003828_pulmonary_edema1.62806656
32MP0005409_darkened_coat_color1.59576587
33MP0004272_abnormal_basement_membrane1.56384862
34* MP0010630_abnormal_cardiac_muscle1.55675166
35MP0003172_abnormal_lysosome_physiology1.54514620
36MP0004087_abnormal_muscle_fiber1.52102794
37MP0004885_abnormal_endolymph1.46641194
38MP0008057_abnormal_DNA_replication1.45428606
39MP0002877_abnormal_melanocyte_morpholog1.43497947
40MP0001851_eye_inflammation1.43014577
41MP0008438_abnormal_cutaneous_collagen1.42333534
42MP0010234_abnormal_vibrissa_follicle1.42139934
43MP0000747_muscle_weakness1.41432908
44MP0003566_abnormal_cell_adhesion1.41179218
45MP0004145_abnormal_muscle_electrophysio1.33847258
46MP0000751_myopathy1.31811359
47MP0005621_abnormal_cell_physiology1.30080935
48MP0003303_peritoneal_inflammation1.26828613
49MP0008877_abnormal_DNA_methylation1.26259526
50MP0001348_abnormal_lacrimal_gland1.26181104
51MP0006138_congestive_heart_failure1.25086698
52MP0001346_abnormal_lacrimal_gland1.23460592
53MP0000767_abnormal_smooth_muscle1.23067206
54MP0003937_abnormal_limbs/digits/tail_de1.22831914
55MP0003634_abnormal_glial_cell1.20659583
56MP0003787_abnormal_imprinting1.20096927
57MP0002106_abnormal_muscle_physiology1.18604572
58MP0005171_absent_coat_pigmentation1.17075731
59MP0002006_tumorigenesis1.16833839
60MP0008775_abnormal_heart_ventricle1.16548336
61* MP0002925_abnormal_cardiovascular_devel1.15239863
62MP0004742_abnormal_vestibular_system1.13753842
63MP0003136_yellow_coat_color1.13002072
64MP0001790_abnormal_immune_system1.12095821
65MP0005387_immune_system_phenotype1.12095821
66MP0001958_emphysema1.11654202
67MP0001879_abnormal_lymphatic_vessel1.11364969
68MP0005375_adipose_tissue_phenotype1.10746784
69MP0005666_abnormal_adipose_tissue1.09938351
70MP0002796_impaired_skin_barrier1.07037279
71MP0003329_amyloid_beta_deposits1.06509585
72MP0005330_cardiomyopathy1.04520056
73* MP0003984_embryonic_growth_retardation1.04494803
74MP0005310_abnormal_salivary_gland1.04096379
75MP0005369_muscle_phenotype1.03335448
76MP0000428_abnormal_craniofacial_morphol1.03270533
77MP0003632_abnormal_nervous_system1.02614317
78MP0009278_abnormal_bone_marrow1.01939253
79MP0000749_muscle_degeneration1.01095493
80MP0001545_abnormal_hematopoietic_system1.00333501
81MP0005397_hematopoietic_system_phenotyp1.00333501
82MP0008569_lethality_at_weaning1.00318568
83MP0009672_abnormal_birth_weight0.99601091
84* MP0002088_abnormal_embryonic_growth/wei0.99491680
85MP0001661_extended_life_span0.99401233
86MP0000003_abnormal_adipose_tissue0.98970243
87MP0000703_abnormal_thymus_morphology0.98849621
88* MP0001784_abnormal_fluid_regulation0.98366401
89MP0003115_abnormal_respiratory_system0.98223035
90MP0001730_embryonic_growth_arrest0.95883270
91MP0002972_abnormal_cardiac_muscle0.95131998
92MP0000579_abnormal_nail_morphology0.94326157
93MP0004947_skin_inflammation0.94211588
94MP0000759_abnormal_skeletal_muscle0.93367555
95* MP0001915_intracranial_hemorrhage0.92936177
96MP0004264_abnormal_extraembryonic_tissu0.92712728
97MP0009115_abnormal_fat_cell0.92320635
98MP0004859_abnormal_synaptic_plasticity0.90700583
99MP0003279_aneurysm0.90302535
100MP0003890_abnormal_embryonic-extraembry0.89223678
101MP0003453_abnormal_keratinocyte_physiol0.89173713
102MP0002933_joint_inflammation0.89047784
103* MP0002086_abnormal_extraembryonic_tissu0.89006251
104MP0002108_abnormal_muscle_morphology0.88986098
105MP0004147_increased_porphyrin_level0.88933187
106MP0000432_abnormal_head_morphology0.88795798
107MP0003935_abnormal_craniofacial_develop0.87289966
108MP0002971_abnormal_brown_adipose0.87101142
109MP0005620_abnormal_muscle_contractility0.86924871
110MP0003221_abnormal_cardiomyocyte_apopto0.86285443
111MP0002060_abnormal_skin_morphology0.85238405
112MP0009384_cardiac_valve_regurgitation0.84037920
113MP0002269_muscular_atrophy0.82871854
114MP0004484_altered_response_of0.82541157
115* MP0000266_abnormal_heart_morphology0.82227041
116MP0000015_abnormal_ear_pigmentation0.82106670
117MP0002133_abnormal_respiratory_system0.80799972
118MP0005388_respiratory_system_phenotype0.80799972
119MP0005083_abnormal_biliary_tract0.80590114
120* MP0005380_embryogenesis_phenotype0.79928318
121* MP0001672_abnormal_embryogenesis/_devel0.79928318
122MP0010352_gastrointestinal_tract_polyps0.79502064
123MP0004134_abnormal_chest_morphology0.79024326
124MP0001544_abnormal_cardiovascular_syste0.77647178
125MP0005385_cardiovascular_system_phenoty0.77647178
126MP0002168_other_aberrant_phenotype0.77625847
127MP0000350_abnormal_cell_proliferation0.76539792
128MP0000750_abnormal_muscle_regeneration0.76003747
129MP0004215_abnormal_myocardial_fiber0.75027052
130* MP0001614_abnormal_blood_vessel0.73803604
131* MP0002128_abnormal_blood_circulation0.73722316
132MP0001485_abnormal_pinna_reflex0.73572340
133MP0005384_cellular_phenotype0.73511044
134MP0008961_abnormal_basal_metabolism0.73068190
135MP0000778_abnormal_nervous_system0.71112688
136MP0003191_abnormal_cellular_cholesterol0.70836154
137MP0005410_abnormal_fertilization0.70432076
138MP0010307_abnormal_tumor_latency0.69008874
139MP0009703_decreased_birth_body0.68506501
140MP0003385_abnormal_body_wall0.66693963
141MP0010368_abnormal_lymphatic_system0.66430993
142MP0009780_abnormal_chondrocyte_physiolo0.64902444
143MP0003567_abnormal_fetal_cardiomyocyte0.64360918
144MP0002084_abnormal_developmental_patter0.64193863
145MP0000647_abnormal_sebaceous_gland0.63416608

Predicted human phenotypes

RankGene SetZ-score
1Hyporeflexia of lower limbs (HP:0002600)4.11176570
2Degeneration of the lateral corticospinal tracts (HP:0002314)3.65343984
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.65343984
4Obstructive sleep apnea (HP:0002870)3.34727363
5Muscle fiber splitting (HP:0003555)3.22337352
6Dysmetric saccades (HP:0000641)3.21272835
7Abnormality of the fingertips (HP:0001211)3.13843067
8Difficulty running (HP:0009046)3.07222202
9Macroorchidism (HP:0000053)3.03761038
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.89915461
11Onion bulb formation (HP:0003383)2.82004639
12Hypoplastic ischia (HP:0003175)2.73064566
13Poikilocytosis (HP:0004447)2.58954150
14Neurofibrillary tangles (HP:0002185)2.54540042
15Broad face (HP:0000283)2.51404232
16Sensory axonal neuropathy (HP:0003390)2.46331580
17Abnormality of the corticospinal tract (HP:0002492)2.43915365
18Overgrowth (HP:0001548)2.39808133
19Scapular winging (HP:0003691)2.38818213
20Muscle hypertrophy of the lower extremities (HP:0008968)2.34592899
21Hypoplasia of the iris (HP:0007676)2.33839973
22Abnormality of the ischium (HP:0003174)2.32823788
23Termporal pattern (HP:0011008)2.32112151
24Insidious onset (HP:0003587)2.32112151
25Peripheral hypomyelination (HP:0007182)2.31747703
26Dislocated radial head (HP:0003083)2.29282430
27Narrow palate (HP:0000189)2.25734341
28Abnormality of the left ventricular outflow tract (HP:0011103)2.23247587
29Subaortic stenosis (HP:0001682)2.23247587
30Shallow orbits (HP:0000586)2.21786612
31Cerebral inclusion bodies (HP:0100314)2.20136128
32Calf muscle hypertrophy (HP:0008981)2.19524568
33Abnormal auditory evoked potentials (HP:0006958)2.18861093
34Subacute progressive viral hepatitis (HP:0006572)2.17732323
35Volvulus (HP:0002580)2.10707234
36Truncal obesity (HP:0001956)2.10203957
37Neonatal hypoglycemia (HP:0001998)2.08778438
38Abnormality of the nasal septum (HP:0000419)2.07559890
39Germ cell neoplasia (HP:0100728)2.07457119
40Right ventricular cardiomyopathy (HP:0011663)2.06716094
41Absent frontal sinuses (HP:0002688)2.06245617
42Abnormality of the radial head (HP:0003995)2.06136064
43Cerebral aneurysm (HP:0004944)2.06108965
44Lip pit (HP:0100267)2.04546810
45Disproportionate tall stature (HP:0001519)2.02855632
46Long eyelashes (HP:0000527)2.02030316
47Increased connective tissue (HP:0009025)2.01559294
48Premature skin wrinkling (HP:0100678)1.99697439
49Depressed nasal tip (HP:0000437)1.99286300
50Abnormality of the distal phalanx of the thumb (HP:0009617)1.99246118
51Hyperacusis (HP:0010780)1.99242547
52Persistence of primary teeth (HP:0006335)1.98798355
53Arterial tortuosity (HP:0005116)1.96511228
54Distal lower limb amyotrophy (HP:0008944)1.95496618
55Mitral valve prolapse (HP:0001634)1.95205775
56Sudden death (HP:0001699)1.93682341
57Trigonocephaly (HP:0000243)1.93507269
58Foot dorsiflexor weakness (HP:0009027)1.93074163
59Slow saccadic eye movements (HP:0000514)1.92307066
60Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90807567
61Anteriorly placed anus (HP:0001545)1.90326968
62Hematochezia (HP:0002573)1.89947098
63Deep philtrum (HP:0002002)1.88473129
64Widely spaced teeth (HP:0000687)1.87542525
65Chin dimple (HP:0010751)1.87269015
66Centrally nucleated skeletal muscle fibers (HP:0003687)1.87228288
67Ankyloglossia (HP:0010296)1.87055507
68Lower limb amyotrophy (HP:0007210)1.86760071
69Pulmonary artery stenosis (HP:0004415)1.86244740
70Spondylolisthesis (HP:0003302)1.85843794
71Atrial fibrillation (HP:0005110)1.85807261
72Abnormality of the foot musculature (HP:0001436)1.85474632
73Gowers sign (HP:0003391)1.83379385
74Abnormality of the salivary glands (HP:0010286)1.82983414
75Broad metatarsal (HP:0001783)1.82934631
76Bell-shaped thorax (HP:0001591)1.82893026
77Supernumerary ribs (HP:0005815)1.82688198
78Abnormality of the calf musculature (HP:0001430)1.82266181
79Mask-like facies (HP:0000298)1.80486622
80Advanced eruption of teeth (HP:0006288)1.79272464
81Abnormality of the columella (HP:0009929)1.79246916
82Resting tremor (HP:0002322)1.78443816
83Postural instability (HP:0002172)1.77540299
84Relative macrocephaly (HP:0004482)1.77190686
85Aneurysm (HP:0002617)1.76643649
86Syringomyelia (HP:0003396)1.76569508
87Spinal cord lesions (HP:0100561)1.76569508
88Ectopic kidney (HP:0000086)1.76455108
89Limited hip movement (HP:0008800)1.75735593
90Scanning speech (HP:0002168)1.75669560
91Increased variability in muscle fiber diameter (HP:0003557)1.75351162
92Limited elbow extension (HP:0001377)1.75082127
93Decreased motor nerve conduction velocity (HP:0003431)1.73169191
94Vascular tortuosity (HP:0004948)1.73051522
95Obsessive-compulsive behavior (HP:0000722)1.72907599
96Aplasia cutis congenita (HP:0001057)1.71410405
97Laryngomalacia (HP:0001601)1.71199067
98Insomnia (HP:0100785)1.70197219
99Hip contracture (HP:0003273)1.69946904
100Low anterior hairline (HP:0000294)1.68496021
101Vertebral arch anomaly (HP:0008438)1.68112701
102Cubitus valgus (HP:0002967)1.67060669
103Prominent nose (HP:0000448)1.67002495
104Abnormality of chromosome segregation (HP:0002916)1.66335850
105Round ear (HP:0100830)1.65568819
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.64724718
107EMG: myopathic abnormalities (HP:0003458)1.64303473
108Abnormality of the frontal sinuses (HP:0002687)1.64120265
109Acute myeloid leukemia (HP:0004808)1.63799005
110Heterotopia (HP:0002282)1.63501048
111Genetic anticipation (HP:0003743)1.63359660
112Bowel incontinence (HP:0002607)1.63064543
113Flat acetabular roof (HP:0003180)1.62824673
114Bundle branch block (HP:0011710)1.62142063
115Metaphyseal cupping (HP:0003021)1.62121723
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61930486
117Primary atrial arrhythmia (HP:0001692)1.61927659
118Exercise-induced myalgia (HP:0003738)1.61614671
119Urinary bladder sphincter dysfunction (HP:0002839)1.61564501
120Premature rupture of membranes (HP:0001788)1.61201879
121Polycythemia (HP:0001901)1.60073433
122Thick nail (HP:0001805)1.60066633
123Hypochromic microcytic anemia (HP:0004840)1.59871641
124Abnormality of skeletal muscle fiber size (HP:0012084)1.59324165
125Segmental peripheral demyelination/remyelination (HP:0003481)1.59277152
126Asymmetry of the thorax (HP:0001555)1.59048818
127Spontaneous hematomas (HP:0007420)1.58900846
128Precocious puberty (HP:0000826)1.58263705
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58208502
130Aqueductal stenosis (HP:0002410)1.57448939
131Infantile muscular hypotonia (HP:0008947)1.57268180
132Broad palm (HP:0001169)1.57152711
133EMG: neuropathic changes (HP:0003445)1.56811994
134Supranuclear gaze palsy (HP:0000605)1.56225715
135Sandal gap (HP:0001852)1.56202940
136Dysmetria (HP:0001310)1.55261522
137Midline defect of the nose (HP:0004122)1.55050969
138Aortic aneurysm (HP:0004942)1.54927220
139Exercise-induced muscle cramps (HP:0003710)1.53597924
140Abnormality of nail color (HP:0100643)1.52830065
141Abnormality of the parietal bone (HP:0002696)1.52804970
142Reticulocytosis (HP:0001923)1.50713493
143Menstrual irregularities (HP:0000858)1.50662236
144Urethral obstruction (HP:0000796)1.50552059
145Thick eyebrow (HP:0000574)1.50414340
146Transitional cell carcinoma of the bladder (HP:0006740)1.50220317
147Papillary thyroid carcinoma (HP:0002895)1.49905091
148Parakeratosis (HP:0001036)1.49665290
149Spastic gait (HP:0002064)1.49581603
150Abnormal vertebral ossification (HP:0100569)1.49029255
151Abnormality of incisor morphology (HP:0011063)1.48691010
152Ulnar bowing (HP:0003031)1.48356656
153Uterine leiomyosarcoma (HP:0002891)1.48355347
154Leiomyosarcoma (HP:0100243)1.48355347
155Hammertoe (HP:0001765)1.48269868
156Abnormality of oral frenula (HP:0000190)1.48189936
157Coronal craniosynostosis (HP:0004440)1.47816928
158Bladder carcinoma (HP:0002862)1.47767625
159Bladder neoplasm (HP:0009725)1.47767625
160Supernumerary bones of the axial skeleton (HP:0009144)1.47725430
161Aortic dissection (HP:0002647)1.47111732
162Sparse lateral eyebrow (HP:0005338)1.47027338
163Short 4th metacarpal (HP:0010044)1.46820159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.35798888
2CDK123.97063766
3EPHB13.64423630
4TRIB32.93337966
5CAMK1G2.69902874
6DMPK2.58627681
7WNK42.46688986
8BRD42.42512816
9CAMK1D2.34694851
10LATS12.34369828
11OXSR12.22590341
12EEF2K2.21297741
13TTN2.10860740
14MAP3K102.10297736
15SGK22.00648462
16ICK1.97091689
17FGFR21.81970221
18FGFR41.74265928
19PKN11.69409817
20SMG11.67051832
21PNCK1.60786640
22STK31.60280509
23RIPK41.56475884
24TRPM71.46189835
25STK101.44085619
26CSNK1A1L1.41596533
27KSR21.38442125
28MET1.33852291
29MAP3K21.30512888
30AKT31.29136441
31PDGFRB1.28713612
32MAP3K141.24767473
33* WNK11.22799202
34BCR1.21774948
35MAP2K31.19041231
36TAOK11.16287308
37CLK11.13403109
38ROCK21.09487128
39ITK1.06085772
40JAK11.04911662
41NUAK11.04874243
42NEK91.04729473
43FGR1.03872118
44NLK1.02214114
45MAP3K130.99651252
46OBSCN0.99449035
47MELK0.98563339
48PRKD10.95850393
49* MTOR0.95597119
50TYRO30.94190873
51EIF2AK10.93522781
52SIK10.92976154
53CAMK40.92486606
54PRKCQ0.89398613
55PAK30.89031063
56NEK60.88447639
57STK380.86786154
58STK40.86350697
59PRKAA20.85650692
60MARK20.81748768
61SIK20.81664626
62CDK90.81343935
63CSNK1D0.80421251
64YES10.79904522
65CAMKK10.79590823
66PRKD30.79477265
67KSR10.79465281
68EPHA30.79447233
69FGFR30.78464207
70MAPK120.77699794
71MAP3K10.77642211
72JAK30.77181488
73MAP3K70.77041247
74PKN20.76731848
75RIPK10.76659486
76PTK60.76630521
77TGFBR20.76306550
78CHUK0.76156417
79BMX0.74138065
80CSK0.72122424
81CSNK1G10.72109406
82INSRR0.71563469
83CDK40.71307690
84STK110.70227007
85PRKCH0.69910991
86HIPK20.69784237
87PAK20.69623755
88MAPK110.69569843
89CDK60.65084294
90HCK0.65034321
91PRPF4B0.64221439
92CAMK10.64080136
93SGK4940.64066895
94SGK2230.64066895
95NTRK30.63799426
96PIK3CA0.63071370
97MAPK100.62344105
98ERN10.62265849
99MAP3K60.62240653
100CDC42BPA0.61828817
101PRKD20.60748149
102LATS20.60343732
103PTK2B0.60163735
104PDK10.59698510
105MAP4K10.59659548
106PTK20.58808301
107MAP3K30.58258463
108CSNK1G30.57939548
109MAPKAPK50.57004564
110ZAP700.55472149
111RET0.54341478
112ALK0.54076764
113MAPK70.53990410
114JAK20.53948103
115PHKG10.53716662
116PHKG20.53716662
117GSK3A0.53572253
118CAMK2D0.53299850
119SGK30.53222538
120PDGFRA0.53048121
121IKBKB0.52598437
122BLK0.51678428
123RAF10.51602592
124STK240.51583007
125PAK60.51474007
126PRKAA10.51121904
127ABL10.50897156
128ROCK10.50840691
129CSNK1G20.49868970
130UHMK10.47954595
131LCK0.47366888
132DYRK1A0.47069218
133ERBB20.46707246
134MAPK10.44382511
135INSR0.43906365
136* SGK10.42958514
137NTRK10.42510664
138PIM10.42467237
139FYN0.42066546
140MAPK150.41377070
141CSF1R0.41281149
142RPS6KA20.41258811
143EGFR0.40465318
144PDPK10.40204993
145FGFR10.39825097
146NTRK20.39042188
147RPS6KC10.38152502
148RPS6KL10.38152502
149TAOK20.37811310
150GSK3B0.37663864
151RPS6KB10.36835601

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.09993073
2Long-term potentiation_Homo sapiens_hsa047201.74192415
3Dilated cardiomyopathy_Homo sapiens_hsa054141.68994415
4Renal cell carcinoma_Homo sapiens_hsa052111.59882360
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.57979288
6Viral myocarditis_Homo sapiens_hsa054161.55922342
7ECM-receptor interaction_Homo sapiens_hsa045121.50423073
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.50228002
9mTOR signaling pathway_Homo sapiens_hsa041501.49201179
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48169164
11Focal adhesion_Homo sapiens_hsa045101.40838561
12Thyroid cancer_Homo sapiens_hsa052161.40559716
13Autoimmune thyroid disease_Homo sapiens_hsa053201.39794494
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.38746525
15Adherens junction_Homo sapiens_hsa045201.37263553
16Axon guidance_Homo sapiens_hsa043601.35896620
17Longevity regulating pathway - mammal_Homo sapiens_hsa042111.35638765
18MicroRNAs in cancer_Homo sapiens_hsa052061.35301499
19Small cell lung cancer_Homo sapiens_hsa052221.34131903
20B cell receptor signaling pathway_Homo sapiens_hsa046621.32066206
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30533466
22T cell receptor signaling pathway_Homo sapiens_hsa046601.25696172
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24045146
24GnRH signaling pathway_Homo sapiens_hsa049121.23931391
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.23146300
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21686628
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21193717
28Proteoglycans in cancer_Homo sapiens_hsa052051.20283757
29Colorectal cancer_Homo sapiens_hsa052101.18346648
30Tight junction_Homo sapiens_hsa045301.18065367
31Ether lipid metabolism_Homo sapiens_hsa005651.17800559
32Allograft rejection_Homo sapiens_hsa053301.17431888
33Chronic myeloid leukemia_Homo sapiens_hsa052201.16959949
34Osteoclast differentiation_Homo sapiens_hsa043801.16397539
35Insulin signaling pathway_Homo sapiens_hsa049101.15197709
36Toxoplasmosis_Homo sapiens_hsa051451.14871621
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14652426
38Prolactin signaling pathway_Homo sapiens_hsa049171.13804204
39Lysine degradation_Homo sapiens_hsa003101.13381416
40Prostate cancer_Homo sapiens_hsa052151.13379520
41Chemokine signaling pathway_Homo sapiens_hsa040621.09356274
42Pancreatic cancer_Homo sapiens_hsa052121.06906182
43AMPK signaling pathway_Homo sapiens_hsa041521.06584273
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05369487
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.03301644
46Notch signaling pathway_Homo sapiens_hsa043301.00602452
47MAPK signaling pathway_Homo sapiens_hsa040100.98967884
48Endocytosis_Homo sapiens_hsa041440.98361165
49Amoebiasis_Homo sapiens_hsa051460.98070028
50Platelet activation_Homo sapiens_hsa046110.97999323
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.97829011
52Circadian rhythm_Homo sapiens_hsa047100.97779499
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97293300
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96712084
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95771636
56Graft-versus-host disease_Homo sapiens_hsa053320.94610512
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94422949
58Hepatitis B_Homo sapiens_hsa051610.94245139
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93770330
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93178749
61Type II diabetes mellitus_Homo sapiens_hsa049300.92759636
62ErbB signaling pathway_Homo sapiens_hsa040120.92056157
63Pathways in cancer_Homo sapiens_hsa052000.90384082
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90027930
65Inositol phosphate metabolism_Homo sapiens_hsa005620.89893009
66Malaria_Homo sapiens_hsa051440.89095973
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88858245
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.88828888
69HIF-1 signaling pathway_Homo sapiens_hsa040660.88245698
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.87502746
71TGF-beta signaling pathway_Homo sapiens_hsa043500.87404471
72Choline metabolism in cancer_Homo sapiens_hsa052310.87026958
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86397686
74Glucagon signaling pathway_Homo sapiens_hsa049220.85551027
75Ras signaling pathway_Homo sapiens_hsa040140.84610230
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84567003
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.83776856
78Rap1 signaling pathway_Homo sapiens_hsa040150.82894162
79Measles_Homo sapiens_hsa051620.82408720
80Leishmaniasis_Homo sapiens_hsa051400.82194371
81Fatty acid biosynthesis_Homo sapiens_hsa000610.81994084
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81596160
83Renin secretion_Homo sapiens_hsa049240.81227247
84Hedgehog signaling pathway_Homo sapiens_hsa043400.81012908
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.80369029
86cAMP signaling pathway_Homo sapiens_hsa040240.79798857
87Hippo signaling pathway_Homo sapiens_hsa043900.79487212
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79326637
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78809526
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78701610
91Wnt signaling pathway_Homo sapiens_hsa043100.78349727
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78307928
93Melanogenesis_Homo sapiens_hsa049160.77489295
94Cholinergic synapse_Homo sapiens_hsa047250.77093091
95Salmonella infection_Homo sapiens_hsa051320.76894623
96Acute myeloid leukemia_Homo sapiens_hsa052210.74977514
97Ovarian steroidogenesis_Homo sapiens_hsa049130.74580232
98TNF signaling pathway_Homo sapiens_hsa046680.74479546
99Bladder cancer_Homo sapiens_hsa052190.74443235
100Hematopoietic cell lineage_Homo sapiens_hsa046400.74211560
101Sphingolipid metabolism_Homo sapiens_hsa006000.73389250
102Hepatitis C_Homo sapiens_hsa051600.73338775
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73297883
104FoxO signaling pathway_Homo sapiens_hsa040680.72882466
105VEGF signaling pathway_Homo sapiens_hsa043700.70509501
106Basal cell carcinoma_Homo sapiens_hsa052170.70417134
107Oxytocin signaling pathway_Homo sapiens_hsa049210.69577444
108Gap junction_Homo sapiens_hsa045400.69471515
109Prion diseases_Homo sapiens_hsa050200.68713713
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67835600
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67512884
112Insulin resistance_Homo sapiens_hsa049310.66866128
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.66768912
114Primary immunodeficiency_Homo sapiens_hsa053400.66131178
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.66101735
116Viral carcinogenesis_Homo sapiens_hsa052030.65739531
117Estrogen signaling pathway_Homo sapiens_hsa049150.65506290
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64744868
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64533042
120Glioma_Homo sapiens_hsa052140.64465571
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63954532
122Melanoma_Homo sapiens_hsa052180.62869897
123Gastric acid secretion_Homo sapiens_hsa049710.62676971
124Shigellosis_Homo sapiens_hsa051310.62384466
125Endometrial cancer_Homo sapiens_hsa052130.61693783
126Long-term depression_Homo sapiens_hsa047300.61654523
127Thyroid hormone synthesis_Homo sapiens_hsa049180.61575836
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60788459
129Apoptosis_Homo sapiens_hsa042100.60648646
130HTLV-I infection_Homo sapiens_hsa051660.60450761
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60316907
132Non-small cell lung cancer_Homo sapiens_hsa052230.60312805
133Influenza A_Homo sapiens_hsa051640.59464928
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55447461

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