WNK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.86346132
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26693881
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.58004339
4presynaptic membrane assembly (GO:0097105)4.42847286
5nucleobase catabolic process (GO:0046113)4.05850151
6layer formation in cerebral cortex (GO:0021819)4.00071467
7presynaptic membrane organization (GO:0097090)3.88787426
8DNA double-strand break processing (GO:0000729)3.81683147
9synaptic vesicle exocytosis (GO:0016079)3.75839467
10synaptic vesicle maturation (GO:0016188)3.73718402
11locomotory exploration behavior (GO:0035641)3.70500141
12regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69743810
13regulation of synaptic vesicle exocytosis (GO:2000300)3.60419976
14dendritic spine morphogenesis (GO:0060997)3.55610176
15innervation (GO:0060384)3.52152854
16stress granule assembly (GO:0034063)3.42115597
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.41739101
18neuron cell-cell adhesion (GO:0007158)3.37520627
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33832136
20glutamate secretion (GO:0014047)3.32885660
21limb bud formation (GO:0060174)3.32790777
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31907751
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.31907751
24regulation of translation, ncRNA-mediated (GO:0045974)3.31907751
25postsynaptic membrane organization (GO:0001941)3.31862063
26vocalization behavior (GO:0071625)3.30305637
27pre-miRNA processing (GO:0031054)3.28919602
28regulation of glutamate receptor signaling pathway (GO:1900449)3.27457949
29positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25737600
30neurotransmitter-gated ion channel clustering (GO:0072578)3.25090461
31protein localization to synapse (GO:0035418)3.24617602
32axonal fasciculation (GO:0007413)3.22931262
33exploration behavior (GO:0035640)3.22489797
34neuron recognition (GO:0008038)3.22143955
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.21981550
36regulation of synaptic vesicle transport (GO:1902803)3.21231890
37neurotransmitter secretion (GO:0007269)3.13190184
38retinal ganglion cell axon guidance (GO:0031290)3.10986355
39synaptic vesicle endocytosis (GO:0048488)3.04219455
40cerebellar Purkinje cell differentiation (GO:0021702)2.99162453
41olfactory bulb development (GO:0021772)2.96770092
42cell migration in hindbrain (GO:0021535)2.96453453
43mechanosensory behavior (GO:0007638)2.94566005
44nonmotile primary cilium assembly (GO:0035058)2.91015433
45positive regulation of synapse maturation (GO:0090129)2.89989632
46neural tube formation (GO:0001841)2.88208534
47synaptic transmission, glutamatergic (GO:0035249)2.88201333
48regulation of neuronal synaptic plasticity (GO:0048168)2.87818161
49intraciliary transport (GO:0042073)2.87043877
50regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86905475
51regulation of calcium ion-dependent exocytosis (GO:0017158)2.85974340
52cerebellum development (GO:0021549)2.84490824
53ionotropic glutamate receptor signaling pathway (GO:0035235)2.82304479
54replication fork processing (GO:0031297)2.81183039
55behavioral response to nicotine (GO:0035095)2.80328173
56somite development (GO:0061053)2.79823172
57glycine transport (GO:0015816)2.78984514
58regulation of synapse structural plasticity (GO:0051823)2.78585231
59DNA strand renaturation (GO:0000733)2.77786694
60neuron-neuron synaptic transmission (GO:0007270)2.76972226
61negative regulation of DNA-dependent DNA replication (GO:2000104)2.74563580
62dendrite morphogenesis (GO:0048813)2.74349798
63positive regulation of amino acid transport (GO:0051957)2.73030120
64positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.72658154
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70139766
66chromatin remodeling at centromere (GO:0031055)2.69910157
67kidney morphogenesis (GO:0060993)2.66949578
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66683089
69central nervous system projection neuron axonogenesis (GO:0021952)2.66292267
70negative regulation of microtubule polymerization (GO:0031115)2.64118458
71positive regulation of vesicle fusion (GO:0031340)2.64091175
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63385670
73positive regulation of dendritic spine morphogenesis (GO:0061003)2.63259240
74activation of protein kinase A activity (GO:0034199)2.61093470
75atrial cardiac muscle cell action potential (GO:0086014)2.61006187
76dendritic spine organization (GO:0097061)2.59851870
77negative regulation of DNA recombination (GO:0045910)2.59398396
78glutamate receptor signaling pathway (GO:0007215)2.58121559
79resolution of meiotic recombination intermediates (GO:0000712)2.55900577
80calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55553447
81protein localization to cilium (GO:0061512)2.55473650
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55268609
83membrane hyperpolarization (GO:0060081)2.54318200
84cerebral cortex radially oriented cell migration (GO:0021799)2.54289774
85insulin secretion (GO:0030073)2.52713286
86DNA damage response, detection of DNA damage (GO:0042769)2.51656199
87establishment of nucleus localization (GO:0040023)2.51446467
88synapse assembly (GO:0007416)2.51403935
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51068287
90regulation of mitotic spindle checkpoint (GO:1903504)2.51068287
91regulation of telomere maintenance (GO:0032204)2.50254832
92regulation of timing of cell differentiation (GO:0048505)2.50108647
93organelle transport along microtubule (GO:0072384)2.50099174
94positive regulation of synapse assembly (GO:0051965)2.49459362
95regulation of vesicle fusion (GO:0031338)2.49398091
96vesicle transport along microtubule (GO:0047496)2.49248729
97growth hormone secretion (GO:0030252)2.49174135
98proline transport (GO:0015824)2.49135478
99histone exchange (GO:0043486)2.49054316
100regulation of collateral sprouting (GO:0048670)2.48846944
101CENP-A containing nucleosome assembly (GO:0034080)2.48336114
102auditory behavior (GO:0031223)2.47978258
103regulation of development, heterochronic (GO:0040034)2.47328270
104epithelial cilium movement (GO:0003351)2.46765182
105response to dietary excess (GO:0002021)2.46444593
106spinal cord development (GO:0021510)2.46169918
107transmission of nerve impulse (GO:0019226)2.44721753
108neuromuscular process controlling posture (GO:0050884)2.43881221
109establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43753547
110mitochondrion transport along microtubule (GO:0047497)2.43753547
111hindbrain development (GO:0030902)2.43658250
112regulation of postsynaptic membrane potential (GO:0060078)2.43241266
113regulation of cilium movement (GO:0003352)2.43134972
114detection of calcium ion (GO:0005513)2.42820591
115regulation of cAMP-dependent protein kinase activity (GO:2000479)2.42531032
116neurotransmitter transport (GO:0006836)2.42311024
117behavioral defense response (GO:0002209)2.41829023
118behavioral fear response (GO:0001662)2.41829023
119establishment of mitochondrion localization (GO:0051654)2.41405564
120gamma-aminobutyric acid transport (GO:0015812)2.41283724
121protein polyglutamylation (GO:0018095)2.40931799
122long-term memory (GO:0007616)2.40865483
123water-soluble vitamin biosynthetic process (GO:0042364)2.39973335
124cerebellar Purkinje cell layer development (GO:0021680)2.39308222
125cilium morphogenesis (GO:0060271)2.38874142
126negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37472652
127dendrite development (GO:0016358)2.37022531
128dorsal/ventral axis specification (GO:0009950)2.36663704
129histone H4-K12 acetylation (GO:0043983)2.36584595
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.36310735
131* positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.36151799
132startle response (GO:0001964)2.35842736
133pyrimidine nucleobase catabolic process (GO:0006208)2.35802003
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.35499714
135regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.35400647
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35375642
137histone H2A acetylation (GO:0043968)2.34810266
138hippocampus development (GO:0021766)2.34452414
139positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.33304200
140central nervous system neuron axonogenesis (GO:0021955)2.32065027
141chemosensory behavior (GO:0007635)2.31735783
142regulation of neurotransmitter secretion (GO:0046928)2.31453611
143signal release (GO:0023061)2.30962302
144regulation of excitatory postsynaptic membrane potential (GO:0060079)2.30536104
145membrane depolarization during action potential (GO:0086010)2.28785722
146cell differentiation in hindbrain (GO:0021533)2.27598412
147retinal cone cell development (GO:0046549)2.27429002
148regulation of meiosis I (GO:0060631)2.27319692
149photoreceptor cell maintenance (GO:0045494)2.25975716
150regulation of dendritic spine morphogenesis (GO:0061001)2.25776629
151negative regulation of axon guidance (GO:1902668)2.25594091
152cilium organization (GO:0044782)2.25436189
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24854531
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.24854531
155cilium assembly (GO:0042384)2.24204503
156response to auditory stimulus (GO:0010996)2.24090445
157regulation of synaptic transmission, GABAergic (GO:0032228)2.24023802
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.23952699
159cullin deneddylation (GO:0010388)2.23604299
160neuromuscular process controlling balance (GO:0050885)2.23574850
161genetic imprinting (GO:0071514)2.23263471
162positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.23255171
163sympathetic nervous system development (GO:0048485)2.23104016
164positive regulation of histone H3-K4 methylation (GO:0051571)2.22768491
165regulation of hexokinase activity (GO:1903299)2.22734693
166regulation of glucokinase activity (GO:0033131)2.22734693
167neuron fate determination (GO:0048664)2.22398397
168microtubule depolymerization (GO:0007019)2.19819376
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.19181624
170detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.18411400
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.18400215
172somite rostral/caudal axis specification (GO:0032525)2.18316199
173exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.18058061
174behavioral response to ethanol (GO:0048149)2.17761682
175respiratory chain complex IV assembly (GO:0008535)2.17580110
176centriole replication (GO:0007099)2.16816375
177prenylation (GO:0097354)2.16466440
178protein prenylation (GO:0018342)2.16466440
179microtubule anchoring (GO:0034453)2.15819588
180neuronal action potential propagation (GO:0019227)2.15530471
181C4-dicarboxylate transport (GO:0015740)2.15122594
182spinal cord motor neuron differentiation (GO:0021522)2.15117875
183protein-cofactor linkage (GO:0018065)2.13825306
184cerebral cortex cell migration (GO:0021795)2.12868202
185glycosphingolipid biosynthetic process (GO:0006688)2.11265877
186female gonad development (GO:0008585)2.10888485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55300756
2GBX2_23144817_ChIP-Seq_PC3_Human3.17248167
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97250275
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74138239
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.59101819
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43861993
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42285344
8VDR_22108803_ChIP-Seq_LS180_Human2.40808625
9REST_21632747_ChIP-Seq_MESCs_Mouse2.37713931
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34130239
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.31142073
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.29540254
13EWS_26573619_Chip-Seq_HEK293_Human2.26067301
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15339928
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13477315
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07586393
17IGF1R_20145208_ChIP-Seq_DFB_Human2.05368251
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05286555
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.01486893
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.98080757
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96911255
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93253375
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.82430233
24RNF2_27304074_Chip-Seq_NSC_Mouse1.81846725
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.77319472
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76642922
27ZNF274_21170338_ChIP-Seq_K562_Hela1.75274921
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73623790
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71876382
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71515670
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71097177
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68318674
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67938933
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65677393
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65677393
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64960061
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64276012
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.64019909
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63249771
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62464568
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61101224
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60225405
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.60008253
44SMAD4_21799915_ChIP-Seq_A2780_Human1.53875419
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53539131
46FUS_26573619_Chip-Seq_HEK293_Human1.53209287
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51174693
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50394169
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50089530
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49178948
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.48450074
52DROSHA_22980978_ChIP-Seq_HELA_Human1.46867180
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46540429
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46244100
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45659714
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.44578633
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42429169
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40217941
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.39635892
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39199441
61AR_25329375_ChIP-Seq_VCAP_Human1.39047757
62CBP_20019798_ChIP-Seq_JUKART_Human1.38831449
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38831449
64ER_23166858_ChIP-Seq_MCF-7_Human1.38558378
65STAT3_23295773_ChIP-Seq_U87_Human1.37911922
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37348767
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36760825
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.34096799
69BCAT_22108803_ChIP-Seq_LS180_Human1.33806465
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33264919
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32507034
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32345405
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32183776
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31986063
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30277191
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28769765
77P300_19829295_ChIP-Seq_ESCs_Human1.28279528
78AR_21572438_ChIP-Seq_LNCaP_Human1.28219653
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25415471
80ELK1_19687146_ChIP-ChIP_HELA_Human1.23965322
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23896938
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23265246
83AR_19668381_ChIP-Seq_PC3_Human1.23214379
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23039975
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.22858854
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22241579
87IRF1_19129219_ChIP-ChIP_H3396_Human1.21835975
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21470638
89MYC_18940864_ChIP-ChIP_HL60_Human1.21148478
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.21012807
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19922207
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19410775
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19080601
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.19077664
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18946529
96TAF15_26573619_Chip-Seq_HEK293_Human1.18539279
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18390691
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17362684
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17326969
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16964111
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.16169157
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15986345
103TCF4_22108803_ChIP-Seq_LS180_Human1.15889620
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15668082
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15552210
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.13499392
107TCF4_23295773_ChIP-Seq_U87_Human1.13119357
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13104461
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13066199
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12819954
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.12380383
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.12240545
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11571551
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10706467
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.10567859
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09923356
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07175255
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06747635
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06148594
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05997138
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.05871488
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05768199
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04694010
124SOX2_19829295_ChIP-Seq_ESCs_Human1.03144625
125NANOG_19829295_ChIP-Seq_ESCs_Human1.03144625
126NANOG_16153702_ChIP-ChIP_HESCs_Human1.03100441
127P53_22387025_ChIP-Seq_ESCs_Mouse1.03031204
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02811441
129SOX9_26525672_Chip-Seq_HEART_Mouse1.01464578
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00473546
131SMAD3_21741376_ChIP-Seq_ESCs_Human1.00124527
132JUN_21703547_ChIP-Seq_K562_Human0.99995046
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.99385820
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99227753
135REST_19997604_ChIP-ChIP_NEURONS_Mouse0.98925858
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.98443764
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98030809
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.97808350
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97700096
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97700096
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97498194
142RUNX2_22187159_ChIP-Seq_PCA_Human0.97274051
143TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97164091
144TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97015869
145TP53_22573176_ChIP-Seq_HFKS_Human0.96848218
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96804793
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.96086563
148POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95851263
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.94613125
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94371225
151SOX2_16153702_ChIP-ChIP_HESCs_Human0.94025473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.12915347
2MP0004859_abnormal_synaptic_plasticity3.72771459
3MP0005645_abnormal_hypothalamus_physiol3.17090164
4MP0003121_genomic_imprinting3.10169124
5MP0004270_analgesia3.06666826
6MP0003123_paternal_imprinting2.65373433
7MP0003880_abnormal_central_pattern2.61219680
8MP0003635_abnormal_synaptic_transmissio2.59186450
9MP0003787_abnormal_imprinting2.53207262
10MP0000013_abnormal_adipose_tissue2.45913293
11MP0002063_abnormal_learning/memory/cond2.30307295
12MP0000778_abnormal_nervous_system2.23558240
13MP0006292_abnormal_olfactory_placode2.07070107
14MP0008877_abnormal_DNA_methylation2.06382987
15MP0002909_abnormal_adrenal_gland2.04111448
16MP0002572_abnormal_emotion/affect_behav2.01740742
17MP0003890_abnormal_embryonic-extraembry1.98921292
18MP0002734_abnormal_mechanical_nocicepti1.90848751
19MP0009046_muscle_twitch1.89364792
20MP0009745_abnormal_behavioral_response1.88807068
21MP0002184_abnormal_innervation1.87412282
22MP0002736_abnormal_nociception_after1.87209881
23MP0006276_abnormal_autonomic_nervous1.84927516
24MP0000569_abnormal_digit_pigmentation1.80377332
25MP0002064_seizures1.77066995
26MP0005423_abnormal_somatic_nervous1.71862949
27MP0002557_abnormal_social/conspecific_i1.71074687
28MP0008058_abnormal_DNA_repair1.62500751
29MP0000631_abnormal_neuroendocrine_gland1.62352848
30MP0002733_abnormal_thermal_nociception1.60677788
31MP0000566_synostosis1.57044439
32MP0001486_abnormal_startle_reflex1.55760244
33MP0003136_yellow_coat_color1.55738187
34MP0002272_abnormal_nervous_system1.54396572
35MP0003937_abnormal_limbs/digits/tail_de1.50930405
36MP0003119_abnormal_digestive_system1.48774090
37MP0008995_early_reproductive_senescence1.47617308
38MP0004811_abnormal_neuron_physiology1.46556270
39MP0006072_abnormal_retinal_apoptosis1.44733194
40MP0001440_abnormal_grooming_behavior1.42275260
41MP0000955_abnormal_spinal_cord1.40484552
42MP0001485_abnormal_pinna_reflex1.38114998
43MP0002751_abnormal_autonomic_nervous1.36929838
44MP0003283_abnormal_digestive_organ1.36032494
45MP0004233_abnormal_muscle_weight1.35234100
46MP0001529_abnormal_vocalization1.34721053
47MP0001984_abnormal_olfaction1.33666231
48MP0001968_abnormal_touch/_nociception1.33489138
49MP0009780_abnormal_chondrocyte_physiolo1.33047356
50MP0005646_abnormal_pituitary_gland1.31723314
51MP0003183_abnormal_peptide_metabolism1.28127290
52MP0002653_abnormal_ependyma_morphology1.26460040
53MP0004924_abnormal_behavior1.26131006
54MP0005386_behavior/neurological_phenoty1.26131006
55MP0005248_abnormal_Harderian_gland1.24759385
56MP0001970_abnormal_pain_threshold1.24282931
57MP0000003_abnormal_adipose_tissue1.20867548
58MP0003718_maternal_effect1.20680878
59MP0004885_abnormal_endolymph1.20606458
60MP0003567_abnormal_fetal_cardiomyocyte1.20200499
61MP0005394_taste/olfaction_phenotype1.20199431
62MP0005499_abnormal_olfactory_system1.20199431
63MP0005379_endocrine/exocrine_gland_phen1.19945641
64MP0002152_abnormal_brain_morphology1.18894863
65MP0002067_abnormal_sensory_capabilities1.17983244
66MP0002882_abnormal_neuron_morphology1.17531590
67MP0003861_abnormal_nervous_system1.15684895
68MP0003879_abnormal_hair_cell1.15323918
69MP0000049_abnormal_middle_ear1.14188307
70MP0000516_abnormal_urinary_system1.13044060
71MP0005367_renal/urinary_system_phenotyp1.13044060
72MP0010094_abnormal_chromosome_stability1.11593801
73MP0001502_abnormal_circadian_rhythm1.10880670
74MP0002638_abnormal_pupillary_reflex1.10863336
75MP0004742_abnormal_vestibular_system1.08708310
76MP0005187_abnormal_penis_morphology1.08395190
77MP0000537_abnormal_urethra_morphology1.08321495
78MP0002735_abnormal_chemical_nociception1.07864677
79MP0000647_abnormal_sebaceous_gland1.06851548
80MP0004145_abnormal_muscle_electrophysio1.04789060
81MP0001286_abnormal_eye_development1.03958001
82MP0004142_abnormal_muscle_tone1.02755055
83MP0002102_abnormal_ear_morphology1.02741722
84MP0010386_abnormal_urinary_bladder1.00646428
85MP0003938_abnormal_ear_development0.99517444
86MP0005195_abnormal_posterior_eye0.98831976
87MP0005391_vision/eye_phenotype0.97878008
88MP0002066_abnormal_motor_capabilities/c0.96692069
89MP0002234_abnormal_pharynx_morphology0.96327628
90MP0001177_atelectasis0.94722509
91MP0001299_abnormal_eye_distance/0.93970511
92MP0001944_abnormal_pancreas_morphology0.93217616
93MP0000427_abnormal_hair_cycle0.93008179
94MP0008057_abnormal_DNA_replication0.92987727
95MP0002938_white_spotting0.90587420
96MP0008789_abnormal_olfactory_epithelium0.90067673
97MP0000026_abnormal_inner_ear0.89907132
98MP0002697_abnormal_eye_size0.88524751
99MP0004215_abnormal_myocardial_fiber0.86906684
100MP0000372_irregular_coat_pigmentation0.86182340
101MP0004133_heterotaxia0.85335788
102MP0005253_abnormal_eye_physiology0.84891436
103MP0001188_hyperpigmentation0.84135320
104MP0001501_abnormal_sleep_pattern0.82806240
105MP0008569_lethality_at_weaning0.82752617
106MP0003011_delayed_dark_adaptation0.82642327
107MP0004043_abnormal_pH_regulation0.82158078
108MP0003693_abnormal_embryo_hatching0.81464321
109MP0005084_abnormal_gallbladder_morpholo0.80976690
110MP0003698_abnormal_male_reproductive0.80920002
111MP0003137_abnormal_impulse_conducting0.80493967
112MP0008932_abnormal_embryonic_tissue0.80419626
113MP0001324_abnormal_eye_pigmentation0.80284000
114MP0002084_abnormal_developmental_patter0.79404778
115MP0002837_dystrophic_cardiac_calcinosis0.79397084
116MP0002069_abnormal_eating/drinking_beha0.78949575
117MP0000534_abnormal_ureter_morphology0.76380055
118MP0004858_abnormal_nervous_system0.75557364
119MP0002163_abnormal_gland_morphology0.74554279
120MP0003935_abnormal_craniofacial_develop0.73693143
121MP0010234_abnormal_vibrissa_follicle0.72262361
122MP0003942_abnormal_urinary_system0.70030569
123MP0002081_perinatal_lethality0.69542353
124MP0008961_abnormal_basal_metabolism0.69025857
125MP0009703_decreased_birth_body0.68505037
126MP0003195_calcinosis0.67979713
127MP0005076_abnormal_cell_differentiation0.67381048
128MP0002752_abnormal_somatic_nervous0.67331302
129MP0001293_anophthalmia0.67087877
130MP0003633_abnormal_nervous_system0.66306103
131MP0005551_abnormal_eye_electrophysiolog0.66003383
132MP0002233_abnormal_nose_morphology0.65159604
133MP0002822_catalepsy0.64079555
134MP0003755_abnormal_palate_morphology0.63410928

Predicted human phenotypes

RankGene SetZ-score
1Agitation (HP:0000713)3.72306086
2Focal motor seizures (HP:0011153)3.61769264
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.33426220
4Focal seizures (HP:0007359)3.15291604
5Hemiparesis (HP:0001269)3.08466017
6Intestinal atresia (HP:0011100)3.00430722
7True hermaphroditism (HP:0010459)2.98242590
8Colon cancer (HP:0003003)2.94109457
9Drooling (HP:0002307)2.84349757
10Excessive salivation (HP:0003781)2.84349757
11Pancreatic fibrosis (HP:0100732)2.83427909
12Pancreatic cysts (HP:0001737)2.83205785
13Ankle clonus (HP:0011448)2.80224468
14Abnormality of the labia minora (HP:0012880)2.80223773
15Medial flaring of the eyebrow (HP:0010747)2.78726125
16Abnormality of the astrocytes (HP:0100707)2.77334026
17Astrocytoma (HP:0009592)2.77334026
18Molar tooth sign on MRI (HP:0002419)2.76878976
19Abnormality of midbrain morphology (HP:0002418)2.76878976
20Epileptic encephalopathy (HP:0200134)2.75816793
21Visual hallucinations (HP:0002367)2.75411365
22Myokymia (HP:0002411)2.74969878
23Septo-optic dysplasia (HP:0100842)2.70160849
24Failure to thrive in infancy (HP:0001531)2.68252745
25Genital tract atresia (HP:0001827)2.68183511
26Nephronophthisis (HP:0000090)2.61813987
27Vaginal atresia (HP:0000148)2.61587603
28Progressive cerebellar ataxia (HP:0002073)2.59772543
29EEG with generalized epileptiform discharges (HP:0011198)2.58503746
30Abnormality of the lower motor neuron (HP:0002366)2.58500791
31Epileptiform EEG discharges (HP:0011182)2.57229356
32Hyperglycinemia (HP:0002154)2.53821289
33Hypsarrhythmia (HP:0002521)2.49157825
34Ependymoma (HP:0002888)2.47270418
35Neoplasm of the heart (HP:0100544)2.41071865
36Hypoglycemic seizures (HP:0002173)2.38768928
37Amyotrophic lateral sclerosis (HP:0007354)2.38190341
38Optic nerve hypoplasia (HP:0000609)2.37550644
39Macroorchidism (HP:0000053)2.36374508
40Papillary thyroid carcinoma (HP:0002895)2.35592309
41Abnormality of calcium-phosphate metabolism (HP:0100530)2.32862575
42Polyphagia (HP:0002591)2.30463698
43Hepatoblastoma (HP:0002884)2.28692664
44Restlessness (HP:0000711)2.28117040
45Nephrogenic diabetes insipidus (HP:0009806)2.26597769
46Shoulder girdle muscle weakness (HP:0003547)2.24525648
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.24345352
48Hyperinsulinemic hypoglycemia (HP:0000825)2.24055763
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22695256
50Hyperglycemia (HP:0003074)2.22139259
51Shawl scrotum (HP:0000049)2.21399979
52Methylmalonic acidemia (HP:0002912)2.21108899
53Depression (HP:0000716)2.20952399
54Glioma (HP:0009733)2.20921207
55Absence seizures (HP:0002121)2.20420088
56Oligodactyly (hands) (HP:0001180)2.20250017
57Atonic seizures (HP:0010819)2.19336364
58Meckel diverticulum (HP:0002245)2.19242583
59Abnormality of the renal medulla (HP:0100957)2.19181035
60Abnormality of the ileum (HP:0001549)2.16858755
61Obsessive-compulsive behavior (HP:0000722)2.15866025
62Gastrointestinal atresia (HP:0002589)2.14695767
63Abnormal lung lobation (HP:0002101)2.14049773
64Truncal ataxia (HP:0002078)2.13103946
65Lissencephaly (HP:0001339)2.12701422
66Aqueductal stenosis (HP:0002410)2.11518298
67Febrile seizures (HP:0002373)2.10647368
68Renal hypoplasia (HP:0000089)2.10450132
69Hyperthyroidism (HP:0000836)2.08701432
70Broad-based gait (HP:0002136)2.06379621
71Generalized tonic-clonic seizures (HP:0002069)2.06143702
72Chronic hepatic failure (HP:0100626)2.03899952
73Dialeptic seizures (HP:0011146)2.03439701
74Impaired smooth pursuit (HP:0007772)2.02691580
75Specific learning disability (HP:0001328)2.02506715
76Blue irides (HP:0000635)2.01959389
77Genetic anticipation (HP:0003743)2.01781849
78Anophthalmia (HP:0000528)2.01348675
79Menstrual irregularities (HP:0000858)2.01289847
80Limb dystonia (HP:0002451)2.00895508
81Pendular nystagmus (HP:0012043)1.99801589
82Exotropia (HP:0000577)1.98445234
83Bifid tongue (HP:0010297)1.98248302
84Cortical dysplasia (HP:0002539)1.98090965
85Symptomatic seizures (HP:0011145)1.96962785
86Scrotal hypoplasia (HP:0000046)1.95513742
87Postaxial hand polydactyly (HP:0001162)1.95426563
88Hypoventilation (HP:0002791)1.94803936
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.94206649
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.93625550
91Abolished electroretinogram (ERG) (HP:0000550)1.93574512
92Hand muscle atrophy (HP:0009130)1.93495641
93Poor coordination (HP:0002370)1.93131914
94Abnormality of chromosome stability (HP:0003220)1.93109094
95Narrow forehead (HP:0000341)1.92908215
96Retinal atrophy (HP:0001105)1.92578699
97Pheochromocytoma (HP:0002666)1.91996525
98Abnormal eating behavior (HP:0100738)1.91576209
99Impulsivity (HP:0100710)1.90864107
100Gait imbalance (HP:0002141)1.90241878
101Clonus (HP:0002169)1.90224426
102Anencephaly (HP:0002323)1.89282205
103Sclerocornea (HP:0000647)1.88573383
104Testicular neoplasm (HP:0010788)1.87493409
105Abnormality of ocular smooth pursuit (HP:0000617)1.87137111
106Labial hypoplasia (HP:0000066)1.86301575
107Supranuclear gaze palsy (HP:0000605)1.85543052
108Impaired vibration sensation in the lower limbs (HP:0002166)1.83300933
109Cupped ear (HP:0000378)1.83209293
110Inability to walk (HP:0002540)1.80781424
111Amblyopia (HP:0000646)1.80651700
112Tubulointerstitial nephritis (HP:0001970)1.80012540
113Papilledema (HP:0001085)1.79801812
114Preaxial hand polydactyly (HP:0001177)1.79664075
115Neoplasm of the adrenal cortex (HP:0100641)1.79306927
116Micropenis (HP:0000054)1.78816101
117Male pseudohermaphroditism (HP:0000037)1.77957211
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.77050495
119Dysdiadochokinesis (HP:0002075)1.76993986
120Abnormality of serine family amino acid metabolism (HP:0010894)1.76786449
121Abnormality of glycine metabolism (HP:0010895)1.76786449
122Bilateral microphthalmos (HP:0007633)1.76618749
123Congenital stationary night blindness (HP:0007642)1.76385963
124Open mouth (HP:0000194)1.76344298
125Abnormality of the renal cortex (HP:0011035)1.75555669
126Hypothermia (HP:0002045)1.75490454
127Pancreatic islet-cell hyperplasia (HP:0004510)1.75200217
128Action tremor (HP:0002345)1.75121487
129Pachygyria (HP:0001302)1.74957803
130Absent speech (HP:0001344)1.73896804
131Postaxial foot polydactyly (HP:0001830)1.73886188
132Volvulus (HP:0002580)1.72128363
133Orthostatic hypotension (HP:0001278)1.71745214
134Progressive inability to walk (HP:0002505)1.71437907
135Small hand (HP:0200055)1.70683044
136Dandy-Walker malformation (HP:0001305)1.70497825
137Broad foot (HP:0001769)1.69513779
138Cystic liver disease (HP:0006706)1.69255369
139Hyperventilation (HP:0002883)1.69088418
140Protruding tongue (HP:0010808)1.67028400
141Ankyloglossia (HP:0010296)1.67019223
142Chorioretinal coloboma (HP:0000567)1.66962990
143Renal cortical cysts (HP:0000803)1.66952443
144Absent septum pellucidum (HP:0001331)1.66828848
145Spastic gait (HP:0002064)1.66826023
146Astigmatism (HP:0000483)1.65948126
147Hyperglycinuria (HP:0003108)1.64986748
148Poor eye contact (HP:0000817)1.64729598
149Esophageal atresia (HP:0002032)1.64239575
150Atelectasis (HP:0100750)1.63958644
151Acute necrotizing encephalopathy (HP:0006965)1.63904400
152Urinary bladder sphincter dysfunction (HP:0002839)1.63172864
153Medulloblastoma (HP:0002885)1.63079671
154Bile duct proliferation (HP:0001408)1.63071640
155Abnormal biliary tract physiology (HP:0012439)1.63071640
156Oligodactyly (HP:0012165)1.63042681
157Abnormal hair whorl (HP:0010721)1.62882056
158Hypoplastic female external genitalia (HP:0012815)1.62754707
159Abnormality of the duodenum (HP:0002246)1.62555329
160Pelvic girdle muscle weakness (HP:0003749)1.62209317
161Acute encephalopathy (HP:0006846)1.62191019
162Sleep apnea (HP:0010535)1.61444494
163Neoplasm of the oral cavity (HP:0100649)1.59381328
164Urinary urgency (HP:0000012)1.58912950
165Renal duplication (HP:0000075)1.58807672
166Pointed chin (HP:0000307)1.58282995
167Midline defect of the nose (HP:0004122)1.57851839
168Abnormality of the metopic suture (HP:0005556)1.57669205
169High anterior hairline (HP:0009890)1.56527690
170Congenital primary aphakia (HP:0007707)1.55730799
171Abnormality of endocrine pancreas physiology (HP:0012093)1.55394425
172Abnormality of the pancreatic islet cells (HP:0006476)1.55394425
173Abnormality of salivation (HP:0100755)1.55143239
174Gaze-evoked nystagmus (HP:0000640)1.53504120
175Abnormality of the musculature of the pelvis (HP:0001469)1.53467563
176Abnormality of the hip-girdle musculature (HP:0001445)1.53467563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.96283475
2NTRK33.40622107
3MAP3K43.09876593
4MAP3K92.90430548
5MKNK22.66292696
6TRIM282.65006323
7MAPK152.49677012
8UHMK12.39734674
9KSR12.25793602
10BMPR1B2.24200588
11NTRK22.21906712
12PRKD32.21802274
13PNCK2.17176908
14MAP4K22.16866254
15EPHA42.08714664
16MINK11.99817085
17MKNK11.97141863
18NUAK11.91551221
19MAP2K71.87192802
20ZAK1.85834124
21PAK61.84109905
22EPHB21.71497561
23MAPK131.58010744
24PLK41.57778447
25AKT31.44254650
26DAPK21.42597373
27MAP2K41.41701848
28BUB11.40723123
29FGFR21.40546027
30WNK41.38964393
31KSR21.38357527
32CASK1.37113848
33PINK11.33710490
34WEE11.28333621
35BRSK21.25435077
36SRPK11.24971887
37CDK51.19445262
38BRD41.18451718
39ADRBK21.17686178
40LATS21.17570502
41PAK31.16952708
42MAP3K21.16191544
43TYRO31.14797846
44BCR1.14293446
45CSNK1G21.13180920
46DYRK21.10257916
47DAPK11.09768468
48GRK11.08506333
49ICK1.07832288
50ERBB31.07256028
51STK38L1.06178713
52NTRK11.05373779
53CDK121.05133576
54TTK1.04801119
55FRK1.03761864
56WNK11.03432808
57DYRK30.98756968
58PRKCG0.94154938
59SCYL20.93951282
60DYRK1A0.93401471
61FER0.92906378
62CSNK1A1L0.92248417
63CDC70.92174623
64PIK3CG0.91195892
65CSNK1G30.90084311
66EIF2AK30.89997256
67INSRR0.89538360
68VRK10.88213537
69PLK10.88003912
70CDC42BPA0.86388632
71PLK20.84645690
72ACVR1B0.84592958
73CAMK1G0.84188561
74PLK30.82503306
75PRKCE0.82015518
76STK380.81231371
77OXSR10.80980937
78CDK180.79899292
79NEK20.79675547
80NEK10.79282574
81BRSK10.78357290
82ALK0.77445257
83CDK140.77165149
84TNIK0.77046389
85SGK2230.76574622
86SGK4940.76574622
87PHKG20.75376893
88PHKG10.75376893
89CDK150.75088854
90PKN10.73518648
91TAF10.72246065
92CAMKK10.71562158
93CAMKK20.71321345
94SIK20.69575066
95TSSK60.67748533
96TGFBR10.67440747
97SGK20.67180676
98MAP3K120.66921206
99SGK10.64823552
100CDK11A0.64380701
101CCNB10.64321850
102MAPK100.62956429
103CSNK1G10.61992552
104* WNK30.60670157
105CSNK1E0.60306330
106CAMK2A0.58987835
107YES10.57517238
108ATR0.57422132
109STK390.56426182
110RPS6KA40.56042494
111MTOR0.55959980
112RET0.55941701
113RPS6KA30.54814885
114GSK3B0.53974736
115CDK190.53585690
116STK110.53494868
117CDK10.53412377
118MARK20.53059613
119ERBB20.51069388
120CAMK1D0.50409622
121MAPK80.49404652
122BCKDK0.48684316
123PDK30.48037437
124PDK40.48037437
125PDGFRA0.47223368
126PRKDC0.47160624
127CHEK20.46235983
128CDK30.45730214
129PRKCZ0.45695121
130CSNK1D0.45610108
131CDK20.45601638
132FGFR10.45569474
133RPS6KB10.44980844
134CHEK10.44393161
135PRKAA10.43007086
136CSNK1A10.42622422
137BRAF0.42348874
138ATM0.42192603
139CAMK2B0.42005100
140NLK0.41827881
141MAPK140.41450521
142STK160.37956514
143EIF2AK20.37001520
144SIK30.35226303
145PRKACA0.33472274
146PRKACB0.33019248

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.13625779
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90158749
3Insulin secretion_Homo sapiens_hsa049112.74341403
4Synaptic vesicle cycle_Homo sapiens_hsa047212.63952880
5Protein export_Homo sapiens_hsa030602.51259770
6GABAergic synapse_Homo sapiens_hsa047272.50606650
7Circadian entrainment_Homo sapiens_hsa047132.32949410
8Amphetamine addiction_Homo sapiens_hsa050312.30506091
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28033965
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.27937578
11Steroid biosynthesis_Homo sapiens_hsa001002.27653313
12Long-term potentiation_Homo sapiens_hsa047202.22841621
13Dopaminergic synapse_Homo sapiens_hsa047282.18393962
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18089260
15Non-homologous end-joining_Homo sapiens_hsa034502.15956409
16Propanoate metabolism_Homo sapiens_hsa006402.11870624
17Fanconi anemia pathway_Homo sapiens_hsa034602.10588913
18Morphine addiction_Homo sapiens_hsa050322.07598913
19Glutamatergic synapse_Homo sapiens_hsa047242.06341113
20Butanoate metabolism_Homo sapiens_hsa006502.00557207
21Cocaine addiction_Homo sapiens_hsa050302.00439080
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97985796
23Basal transcription factors_Homo sapiens_hsa030221.82049495
24Olfactory transduction_Homo sapiens_hsa047401.77823782
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76565284
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.75934184
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74145827
28Type II diabetes mellitus_Homo sapiens_hsa049301.70337742
29Renin secretion_Homo sapiens_hsa049241.65004638
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64435243
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63861031
32Oxidative phosphorylation_Homo sapiens_hsa001901.62936432
33Serotonergic synapse_Homo sapiens_hsa047261.62050008
34Oocyte meiosis_Homo sapiens_hsa041141.61531750
35Cholinergic synapse_Homo sapiens_hsa047251.60645565
36Homologous recombination_Homo sapiens_hsa034401.59023414
37Taste transduction_Homo sapiens_hsa047421.58273623
38Selenocompound metabolism_Homo sapiens_hsa004501.55239868
39Axon guidance_Homo sapiens_hsa043601.54336182
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53932939
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51479964
42RNA polymerase_Homo sapiens_hsa030201.51093961
43Mismatch repair_Homo sapiens_hsa034301.50446395
44Long-term depression_Homo sapiens_hsa047301.49734530
45Gap junction_Homo sapiens_hsa045401.49025603
46Parkinsons disease_Homo sapiens_hsa050121.44374340
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43738341
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41913672
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41241362
50Oxytocin signaling pathway_Homo sapiens_hsa049211.40292517
51Salivary secretion_Homo sapiens_hsa049701.39058467
52Estrogen signaling pathway_Homo sapiens_hsa049151.37811477
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34523949
54Gastric acid secretion_Homo sapiens_hsa049711.31249336
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27888434
56Alcoholism_Homo sapiens_hsa050341.24699346
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22823091
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20165376
59cAMP signaling pathway_Homo sapiens_hsa040241.19640358
60GnRH signaling pathway_Homo sapiens_hsa049121.18371142
61Melanogenesis_Homo sapiens_hsa049161.16021142
62Type I diabetes mellitus_Homo sapiens_hsa049401.13504165
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.13198790
64Proteasome_Homo sapiens_hsa030501.13101631
65Vibrio cholerae infection_Homo sapiens_hsa051101.12953914
66Dorso-ventral axis formation_Homo sapiens_hsa043201.12357334
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10664291
68mRNA surveillance pathway_Homo sapiens_hsa030151.08903569
69ErbB signaling pathway_Homo sapiens_hsa040121.07676523
70Huntingtons disease_Homo sapiens_hsa050161.07645544
71Wnt signaling pathway_Homo sapiens_hsa043101.07068505
72Vitamin B6 metabolism_Homo sapiens_hsa007501.06942778
73Glucagon signaling pathway_Homo sapiens_hsa049221.06922385
74mTOR signaling pathway_Homo sapiens_hsa041501.06796465
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05632770
76Linoleic acid metabolism_Homo sapiens_hsa005911.05528318
77Hedgehog signaling pathway_Homo sapiens_hsa043401.05149125
78Calcium signaling pathway_Homo sapiens_hsa040201.03895478
79Circadian rhythm_Homo sapiens_hsa047101.01721442
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00850269
81Fatty acid elongation_Homo sapiens_hsa000621.00597611
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.99529491
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97336776
84Caffeine metabolism_Homo sapiens_hsa002320.97160094
85Ether lipid metabolism_Homo sapiens_hsa005650.96765341
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.96602726
87Tryptophan metabolism_Homo sapiens_hsa003800.95310156
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93857105
89beta-Alanine metabolism_Homo sapiens_hsa004100.91801791
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90228399
91Colorectal cancer_Homo sapiens_hsa052100.89244358
92Peroxisome_Homo sapiens_hsa041460.88863433
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88027379
94Glioma_Homo sapiens_hsa052140.87920821
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87825039
96Endometrial cancer_Homo sapiens_hsa052130.87654884
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87556807
98Pyruvate metabolism_Homo sapiens_hsa006200.87224633
99Nitrogen metabolism_Homo sapiens_hsa009100.87123673
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86675274
101Collecting duct acid secretion_Homo sapiens_hsa049660.84550405
102Hippo signaling pathway_Homo sapiens_hsa043900.83178735
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82883955
104Fatty acid metabolism_Homo sapiens_hsa012120.82445882
105Thyroid hormone synthesis_Homo sapiens_hsa049180.82258216
106Alzheimers disease_Homo sapiens_hsa050100.79822015
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79700087
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77894549
109Retinol metabolism_Homo sapiens_hsa008300.77614680
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77155103
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74922296
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.73687493
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72893955
114Spliceosome_Homo sapiens_hsa030400.72805713
115Nucleotide excision repair_Homo sapiens_hsa034200.71880772
116Renal cell carcinoma_Homo sapiens_hsa052110.71598670
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.70508707
118Phototransduction_Homo sapiens_hsa047440.69764085
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69453907
120Fatty acid degradation_Homo sapiens_hsa000710.69172878
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69162999
122Folate biosynthesis_Homo sapiens_hsa007900.66790400
123Tight junction_Homo sapiens_hsa045300.66078762
124MAPK signaling pathway_Homo sapiens_hsa040100.65898057
125Purine metabolism_Homo sapiens_hsa002300.65892402
126Pancreatic secretion_Homo sapiens_hsa049720.65511943
127One carbon pool by folate_Homo sapiens_hsa006700.65290003
128Choline metabolism in cancer_Homo sapiens_hsa052310.65279502
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.65189750
130Insulin signaling pathway_Homo sapiens_hsa049100.63178920
131Chemical carcinogenesis_Homo sapiens_hsa052040.61806668
132Basal cell carcinoma_Homo sapiens_hsa052170.61029787
133Base excision repair_Homo sapiens_hsa034100.59887816
134Dilated cardiomyopathy_Homo sapiens_hsa054140.59447439
135Metabolic pathways_Homo sapiens_hsa011000.59270378
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59209998
137RNA transport_Homo sapiens_hsa030130.58455712
138Fat digestion and absorption_Homo sapiens_hsa049750.57614704
139Prion diseases_Homo sapiens_hsa050200.57309521
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56660347
141Regulation of autophagy_Homo sapiens_hsa041400.56653385
142Ovarian steroidogenesis_Homo sapiens_hsa049130.54840949
143DNA replication_Homo sapiens_hsa030300.53336585
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52903927
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51634798
146Ras signaling pathway_Homo sapiens_hsa040140.50006076
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48359713
148Inositol phosphate metabolism_Homo sapiens_hsa005620.47992731
149Cardiac muscle contraction_Homo sapiens_hsa042600.44004632
150Endocytosis_Homo sapiens_hsa041440.43921439
151Rap1 signaling pathway_Homo sapiens_hsa040150.41013213
152Cell cycle_Homo sapiens_hsa041100.39352453
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37800155
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37223111
155AMPK signaling pathway_Homo sapiens_hsa041520.36934805
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36086365
157TGF-beta signaling pathway_Homo sapiens_hsa043500.36075063
158N-Glycan biosynthesis_Homo sapiens_hsa005100.32837001
159Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32326033
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.31762122
161RNA degradation_Homo sapiens_hsa030180.30579618

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