WNK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)7.21566012
2urate metabolic process (GO:0046415)6.57592089
3aminoglycoside antibiotic metabolic process (GO:0030647)6.36619578
4lysine metabolic process (GO:0006553)6.32774363
5lysine catabolic process (GO:0006554)6.32774363
6phosphate ion transport (GO:0006817)6.00906126
7organic cation transport (GO:0015695)5.80059597
8drug transport (GO:0015893)5.78913190
9response to mercury ion (GO:0046689)5.49608599
10tricarboxylic acid metabolic process (GO:0072350)5.38677543
11excretion (GO:0007588)5.25716648
12quaternary ammonium group transport (GO:0015697)4.89546854
13peptidyl-glutamic acid carboxylation (GO:0017187)4.76888158
14protein carboxylation (GO:0018214)4.76888158
15phosphate ion transmembrane transport (GO:0035435)4.69872206
16metanephric tubule development (GO:0072170)4.62743358
17metanephric nephron tubule development (GO:0072234)4.62743358
18Golgi transport vesicle coating (GO:0048200)4.62124879
19COPI coating of Golgi vesicle (GO:0048205)4.62124879
20intestinal cholesterol absorption (GO:0030299)4.52574784
21glyoxylate metabolic process (GO:0046487)4.34103677
22metanephric nephron epithelium development (GO:0072243)4.26904252
23aspartate family amino acid catabolic process (GO:0009068)4.24180287
24short-chain fatty acid metabolic process (GO:0046459)4.16923181
25behavioral response to nicotine (GO:0035095)4.15727380
26drug catabolic process (GO:0042737)4.13555603
27metanephric epithelium development (GO:0072207)4.11133041
28cellular response to vitamin D (GO:0071305)4.05307273
29cysteine metabolic process (GO:0006534)4.00790563
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.99713436
31valine metabolic process (GO:0006573)3.95631868
32branched-chain amino acid metabolic process (GO:0009081)3.93676446
33carnitine transport (GO:0015879)3.91777143
34amino-acid betaine transport (GO:0015838)3.91777143
35sulfate transmembrane transport (GO:1902358)3.88117663
36intestinal absorption (GO:0050892)3.85978081
37* renal absorption (GO:0070293)3.84331634
38membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.81503785
392-oxoglutarate metabolic process (GO:0006103)3.80008464
40peptide catabolic process (GO:0043171)3.78763715
41protein retention in ER lumen (GO:0006621)3.78406725
42fatty acid beta-oxidation (GO:0006635)3.76647683
43negative regulation of fibrinolysis (GO:0051918)3.76391709
44* nephron tubule morphogenesis (GO:0072078)3.75942475
45* nephron epithelium morphogenesis (GO:0072088)3.75942475
46L-phenylalanine metabolic process (GO:0006558)3.73961930
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.73961930
48toxin transport (GO:1901998)3.72184942
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.70715817
50L-phenylalanine catabolic process (GO:0006559)3.70715817
51exogenous drug catabolic process (GO:0042738)3.70523141
52regulation of fibrinolysis (GO:0051917)3.69698451
53nephron tubule development (GO:0072080)3.64895514
54very-low-density lipoprotein particle assembly (GO:0034379)3.62323605
55NADH metabolic process (GO:0006734)3.62298187
56regulation of plasminogen activation (GO:0010755)3.60257027
57proline metabolic process (GO:0006560)3.59091929
58high-density lipoprotein particle remodeling (GO:0034375)3.56438176
59positive regulation of protein kinase C signaling (GO:0090037)3.55548053
60sulfate transport (GO:0008272)3.52548866
61L-fucose catabolic process (GO:0042355)3.46494902
62fucose catabolic process (GO:0019317)3.46494902
63L-fucose metabolic process (GO:0042354)3.46494902
644-hydroxyproline metabolic process (GO:0019471)3.46020870
65fatty acid oxidation (GO:0019395)3.41494250
66response to parathyroid hormone (GO:0071107)3.40931702
673-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.40720088
68purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.40720088
69vitamin D metabolic process (GO:0042359)3.40441212
70tricarboxylic acid cycle (GO:0006099)3.38326213
71membrane repolarization during action potential (GO:0086011)3.38100093
72peristalsis (GO:0030432)3.35073738
73phosphate ion homeostasis (GO:0055062)3.34392038
74trivalent inorganic anion homeostasis (GO:0072506)3.34392038
75homocysteine metabolic process (GO:0050667)3.32973922
76lipid oxidation (GO:0034440)3.32505275
77glycoside metabolic process (GO:0016137)3.32434034
78lung epithelium development (GO:0060428)3.30695734
79fucosylation (GO:0036065)3.30226687
80cellular response to vitamin (GO:0071295)3.28447663
81branched-chain amino acid catabolic process (GO:0009083)3.27637333
82nonribosomal peptide biosynthetic process (GO:0019184)3.27607184
83renal tubule development (GO:0061326)3.27487079
84cellular ketone body metabolic process (GO:0046950)3.23969436
85cellular response to ATP (GO:0071318)3.23170339
86reverse cholesterol transport (GO:0043691)3.21692574
87cellular modified amino acid catabolic process (GO:0042219)3.21518193
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.18915687
89transepithelial transport (GO:0070633)3.16589582
90collecting duct development (GO:0072044)3.16495085
91plasma lipoprotein particle assembly (GO:0034377)3.16099388
92regulation of apoptotic process involved in morphogenesis (GO:1902337)3.14345889
93polyol transport (GO:0015791)3.12220394
94protein-lipid complex remodeling (GO:0034368)3.12148971
95macromolecular complex remodeling (GO:0034367)3.12148971
96plasma lipoprotein particle remodeling (GO:0034369)3.12148971
97aromatic amino acid family catabolic process (GO:0009074)3.08661740
98endocardial cushion development (GO:0003197)3.08242026
99regulation of cholesterol homeostasis (GO:2000188)3.04989851
100amino-acid betaine metabolic process (GO:0006577)3.03522819
101response to vitamin A (GO:0033189)3.03442030
102carnitine metabolic process (GO:0009437)3.02868244
103retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02636764
104surfactant homeostasis (GO:0043129)3.02086035
105fatty acid catabolic process (GO:0009062)3.02014175
106positive regulation of fatty acid beta-oxidation (GO:0032000)2.99002683
107meiotic chromosome segregation (GO:0045132)2.96770069
108glutathione biosynthetic process (GO:0006750)2.96145740
109nephron epithelium development (GO:0072009)2.92087558
110positive regulation of fatty acid oxidation (GO:0046321)2.90431899
111plasma lipoprotein particle organization (GO:0071827)2.89905115
112beta-amyloid metabolic process (GO:0050435)2.89614758
113endocrine pancreas development (GO:0031018)2.86884215
114mannosylation (GO:0097502)2.86350146
115ketone body metabolic process (GO:1902224)2.82059850
116regulation of hexokinase activity (GO:1903299)2.81954654
117regulation of glucokinase activity (GO:0033131)2.81954654
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.81785425
119sulfur compound transport (GO:0072348)2.81531251
120peptide hormone processing (GO:0016486)2.81314086
121DNA damage induced protein phosphorylation (GO:0006975)2.81121054
122negative regulation of sodium ion transport (GO:0010766)2.79520460
123peptidyl-glutamic acid modification (GO:0018200)2.79178350
124oxaloacetate metabolic process (GO:0006107)2.76473109
125toxin metabolic process (GO:0009404)2.75859474
126GDP-mannose metabolic process (GO:0019673)2.75700110
127modified amino acid transport (GO:0072337)2.73557702
128pyrimidine ribonucleoside catabolic process (GO:0046133)2.72751294
129triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.71951592
130succinate metabolic process (GO:0006105)2.71569567
131fructose metabolic process (GO:0006000)2.71497349
132arginine metabolic process (GO:0006525)2.71465023
133monocarboxylic acid catabolic process (GO:0072329)2.70452688
134acetyl-CoA metabolic process (GO:0006084)2.68692674
135low-density lipoprotein particle remodeling (GO:0034374)2.67462407
136peptide biosynthetic process (GO:0043043)2.67335502
137regulation of G0 to G1 transition (GO:0070316)2.67308858
138amino acid transmembrane transport (GO:0003333)2.66415746
139COPII vesicle coating (GO:0048208)2.66407778
140regulation of triglyceride biosynthetic process (GO:0010866)2.66016948
141carnitine transmembrane transport (GO:1902603)2.65500721
142DNA strand renaturation (GO:0000733)2.63693907
143cholesterol efflux (GO:0033344)2.61832471
144cellular response to nutrient (GO:0031670)2.61508994
145biotin metabolic process (GO:0006768)2.58713861
146detection of light stimulus involved in sensory perception (GO:0050962)2.57041804
147detection of light stimulus involved in visual perception (GO:0050908)2.57041804
148regulation of hippo signaling (GO:0035330)2.55562553
149glycerophospholipid catabolic process (GO:0046475)2.55492926
150protein-lipid complex subunit organization (GO:0071825)2.55472101
151actin filament depolymerization (GO:0030042)2.55350458
152cellular anion homeostasis (GO:0030002)2.55312221
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54317760
154positive regulation of glycolytic process (GO:0045821)2.53828533
155tryptophan catabolic process (GO:0006569)2.53823241
156indole-containing compound catabolic process (GO:0042436)2.53823241
157indolalkylamine catabolic process (GO:0046218)2.53823241
158* renal tubule morphogenesis (GO:0061333)2.53737620
159regulation of cholesterol biosynthetic process (GO:0045540)2.51964120
160tryptophan metabolic process (GO:0006568)2.51864793
161embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50387782
162protein-lipid complex assembly (GO:0065005)2.50061719
163urogenital system development (GO:0001655)2.47019905
164water-soluble vitamin biosynthetic process (GO:0042364)2.44672671
165negative regulation of leukocyte chemotaxis (GO:0002689)2.43180684
166proline biosynthetic process (GO:0006561)2.42260256
167fucose metabolic process (GO:0006004)2.41057668
168negative regulation of cholesterol transport (GO:0032375)2.40051791
169negative regulation of sterol transport (GO:0032372)2.40051791
170response to pheromone (GO:0019236)2.38296096
171positive regulation of CREB transcription factor activity (GO:0032793)2.37423503
172regulation of apoptotic cell clearance (GO:2000425)2.37261822
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.36641570
174phasic smooth muscle contraction (GO:0014821)2.36618277
175positive regulation of hormone metabolic process (GO:0032352)2.35238261
176basic amino acid transport (GO:0015802)2.34695764
177response to misfolded protein (GO:0051788)2.33691790
178regulation of cholesterol metabolic process (GO:0090181)2.32468641
179misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.28110591
180vitamin transmembrane transport (GO:0035461)2.26265215
181lymphangiogenesis (GO:0001946)2.26228115
182bicarbonate transport (GO:0015701)2.25967781
183DNA replication checkpoint (GO:0000076)2.25956236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.80383932
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57213730
3ZNF274_21170338_ChIP-Seq_K562_Hela3.40035467
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.36106163
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.09870098
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.03515741
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.97210315
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.82901078
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.81700065
10CLOCK_20551151_ChIP-Seq_293T_Human2.59425392
11* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46324975
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41065614
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.36393983
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34895616
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.25019711
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.22076476
17* E2F1_20622854_ChIP-Seq_HELA_Human2.18379482
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.04570493
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.97410589
20ERA_21632823_ChIP-Seq_H3396_Human1.91016483
21PHF8_20622854_ChIP-Seq_HELA_Human1.90449061
22* RARB_24833708_ChIP-Seq_LIVER_Mouse1.83798369
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.83190881
24TBX20_22080862_ChIP-Seq_HEART_Mouse1.83190881
25DROSHA_22980978_ChIP-Seq_HELA_Human1.82608702
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79096562
27TP53_22127205_ChIP-Seq_IMR90_Human1.78048733
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75985421
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73700836
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73652607
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70946766
32GATA4_25053715_ChIP-Seq_YYC3_Human1.70373551
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69904229
34RACK7_27058665_Chip-Seq_MCF-7_Human1.69490323
35P53_21459846_ChIP-Seq_SAOS-2_Human1.68269340
36* LXR_22292898_ChIP-Seq_THP-1_Human1.68076091
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62767107
38BCL6_27268052_Chip-Seq_Bcells_Human1.59150374
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58465577
40* RARA_24833708_ChIP-Seq_LIVER_Mouse1.57520192
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56691015
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55689849
43FOXP1_21924763_ChIP-Seq_HESCs_Human1.55635272
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.55169814
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.53993001
46* RAC3_21632823_ChIP-Seq_H3396_Human1.53445628
47GATA6_25053715_ChIP-Seq_YYC3_Human1.53229837
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52097335
49CTCF_20526341_ChIP-Seq_ESCs_Human1.51588738
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.50581403
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.50407130
52* OCT4_20526341_ChIP-Seq_ESCs_Human1.47241933
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46127810
54MYC_19829295_ChIP-Seq_ESCs_Human1.44367740
55GATA1_22025678_ChIP-Seq_K562_Human1.43901738
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43737992
57TDRD3_21172665_ChIP-Seq_MCF-7_Human1.42978173
58BCOR_27268052_Chip-Seq_Bcells_Human1.42357970
59TAF2_19829295_ChIP-Seq_ESCs_Human1.41910119
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.40276614
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.40013885
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37271190
63* NANOG_20526341_ChIP-Seq_ESCs_Human1.36994052
64* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36222319
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.35606941
66CREB1_26743006_Chip-Seq_LNCaP_Human1.31438173
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31428650
68* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.31360678
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30678907
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30380396
71ZNF263_19887448_ChIP-Seq_K562_Human1.30008698
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.28250958
73* GATA1_19941826_ChIP-Seq_K562_Human1.28035089
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27231104
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25678860
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24521997
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23519407
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23460502
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23176972
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.22907002
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22866038
82* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.22245947
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21467479
84SOX2_20726797_ChIP-Seq_SW620_Human1.21127374
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20440516
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20079464
87FOXH1_21741376_ChIP-Seq_ESCs_Human1.19293326
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19222733
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19218119
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18563820
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18110835
92OCT4_19829295_ChIP-Seq_ESCs_Human1.17326777
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17209990
94TP53_22573176_ChIP-Seq_HFKS_Human1.15888841
95GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.15810596
96* EZH2_27294783_Chip-Seq_ESCs_Mouse1.15739307
97AR_21572438_ChIP-Seq_LNCaP_Human1.15639985
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15389604
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.15199097
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14697830
101ATF3_27146783_Chip-Seq_COLON_Human1.13644986
102* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13148816
103P300_27268052_Chip-Seq_Bcells_Human1.11543053
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11348968
105TP63_22573176_ChIP-Seq_HFKS_Human1.11154271
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11077344
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10967831
108* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10944448
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.10483785
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09931994
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09756816
112* SA1_27219007_Chip-Seq_Bcells_Human1.09138484
113HOXB7_26014856_ChIP-Seq_BT474_Human1.09027084
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08716746
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08307334
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08258745
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08231663
118P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08012687
119GATA3_24758297_ChIP-Seq_MCF-7_Human1.07014040
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06522701
121GABP_19822575_ChIP-Seq_HepG2_Human1.06139537
122* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06124421
123KDM2B_26808549_Chip-Seq_K562_Human1.06058831
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05768356
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04805380
126ISL1_27105846_Chip-Seq_CPCs_Mouse1.03830758
127* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01088197
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01013826
129P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00839794
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00331069
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00309376
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.99051485
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99016917
134CTCF_27219007_Chip-Seq_Bcells_Human0.98948890
135KDM5A_27292631_Chip-Seq_BREAST_Human0.97560426
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97053424
137* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96901866
138VDR_22108803_ChIP-Seq_LS180_Human0.96802030
139NCOR_22424771_ChIP-Seq_293T_Human0.96013426
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95724838
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95656362
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.94437307
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94241398
144SOX2_21211035_ChIP-Seq_LN229_Human0.93913812
145E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93879905
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93000320
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92983539
148JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92912342
149NCOR1_26117541_ChIP-Seq_K562_Human0.92879936
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.92319990
151P68_20966046_ChIP-Seq_HELA_Human0.92266527
152* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90599726
153* GATA2_19941826_ChIP-Seq_K562_Human0.89597960
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.89219668
155P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87712853
156SMC4_20622854_ChIP-Seq_HELA_Human0.87149334
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86709994
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.86152155
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.83610245
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82912018
161AHR_22903824_ChIP-Seq_MCF-7_Human0.81363837
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80540233
163MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80398967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004043_abnormal_pH_regulation5.64032788
2MP0003195_calcinosis5.29108534
3MP0005360_urolithiasis4.42196399
4MP0009643_abnormal_urine_homeostasis3.48794659
5* MP0001765_abnormal_ion_homeostasis3.40596880
6MP0004019_abnormal_vitamin_homeostasis3.35120142
7MP0001756_abnormal_urination3.33377250
8MP0005332_abnormal_amino_acid3.28841216
9MP0003136_yellow_coat_color3.14975914
10MP0002139_abnormal_hepatobiliary_system3.08199258
11MP0002138_abnormal_hepatobiliary_system2.94186232
12MP0003283_abnormal_digestive_organ2.93317337
13MP0002837_dystrophic_cardiac_calcinosis2.67584177
14MP0008961_abnormal_basal_metabolism2.57024083
15* MP0005636_abnormal_mineral_homeostasis2.51095457
16MP0006292_abnormal_olfactory_placode2.37109617
17MP0005377_hearing/vestibular/ear_phenot2.29439885
18MP0003878_abnormal_ear_physiology2.29439885
19MP0010329_abnormal_lipoprotein_level2.24800473
20MP0003252_abnormal_bile_duct2.21174737
21* MP0002136_abnormal_kidney_physiology2.16723020
22MP0000013_abnormal_adipose_tissue2.15942368
23MP0005171_absent_coat_pigmentation2.12343483
24MP0008438_abnormal_cutaneous_collagen1.92598774
25MP0005365_abnormal_bile_salt1.89333853
26MP0000566_synostosis1.86416080
27MP0000678_abnormal_parathyroid_gland1.82910640
28MP0002938_white_spotting1.80119387
29MP0009780_abnormal_chondrocyte_physiolo1.79492904
30MP0003300_gastrointestinal_ulcer1.79410750
31MP0005174_abnormal_tail_pigmentation1.74864173
32MP0005551_abnormal_eye_electrophysiolog1.73773848
33MP0003123_paternal_imprinting1.73470886
34MP0004264_abnormal_extraembryonic_tissu1.72379063
35MP0005220_abnormal_exocrine_pancreas1.63493229
36MP0004133_heterotaxia1.63432531
37MP0001944_abnormal_pancreas_morphology1.61989480
38MP0001958_emphysema1.59834959
39MP0002896_abnormal_bone_mineralization1.59514114
40MP0002909_abnormal_adrenal_gland1.58882236
41MP0005084_abnormal_gallbladder_morpholo1.57717669
42MP0000003_abnormal_adipose_tissue1.54585521
43MP0000538_abnormal_urinary_bladder1.51233471
44MP0005058_abnormal_lysosome_morphology1.49818975
45MP0002928_abnormal_bile_duct1.49771053
46MP0005257_abnormal_intraocular_pressure1.42675153
47MP0008875_abnormal_xenobiotic_pharmacok1.42600106
48MP0002160_abnormal_reproductive_system1.41805168
49MP0010386_abnormal_urinary_bladder1.39458186
50MP0002877_abnormal_melanocyte_morpholog1.36491867
51MP0010368_abnormal_lymphatic_system1.35464497
52MP0004885_abnormal_endolymph1.34990081
53MP0005085_abnormal_gallbladder_physiolo1.34548834
54MP0001188_hyperpigmentation1.32638303
55MP0004084_abnormal_cardiac_muscle1.31461623
56MP0005409_darkened_coat_color1.30217173
57* MP0000230_abnormal_systemic_arterial1.29179885
58MP0002168_other_aberrant_phenotype1.28940450
59MP0005670_abnormal_white_adipose1.27458549
60MP0004272_abnormal_basement_membrane1.27389549
61MP0001502_abnormal_circadian_rhythm1.26762256
62MP0005375_adipose_tissue_phenotype1.26106008
63MP0010234_abnormal_vibrissa_follicle1.22205126
64MP0002078_abnormal_glucose_homeostasis1.17836668
65MP0001968_abnormal_touch/_nociception1.17432090
66MP0003950_abnormal_plasma_membrane1.14532815
67MP0002249_abnormal_larynx_morphology1.13936716
68MP0005666_abnormal_adipose_tissue1.13259480
69MP0001666_abnormal_nutrient_absorption1.12775392
70MP0005410_abnormal_fertilization1.10063600
71MP0002234_abnormal_pharynx_morphology1.09374555
72MP0001348_abnormal_lacrimal_gland1.08155699
73MP0000751_myopathy1.07925479
74MP0001986_abnormal_taste_sensitivity1.06261545
75MP0003172_abnormal_lysosome_physiology1.04430071
76MP0002693_abnormal_pancreas_physiology1.03534844
77MP0003119_abnormal_digestive_system1.01910005
78MP0003959_abnormal_lean_body1.01807251
79MP0006036_abnormal_mitochondrial_physio1.01350425
80MP0004233_abnormal_muscle_weight0.97834969
81MP0006054_spinal_hemorrhage0.97785426
82MP0004215_abnormal_myocardial_fiber0.97567038
83MP0003937_abnormal_limbs/digits/tail_de0.97486798
84MP0001270_distended_abdomen0.94603619
85MP0002135_abnormal_kidney_morphology0.94327100
86MP0003705_abnormal_hypodermis_morpholog0.93425131
87MP0005330_cardiomyopathy0.91751011
88MP0004036_abnormal_muscle_relaxation0.91013859
89MP0005503_abnormal_tendon_morphology0.90993402
90MP0000534_abnormal_ureter_morphology0.90430551
91MP0001661_extended_life_span0.89651481
92MP0002972_abnormal_cardiac_muscle0.87352753
93MP0009046_muscle_twitch0.86398906
94MP0008872_abnormal_physiological_respon0.85120787
95MP0005319_abnormal_enzyme/_coenzyme0.84355213
96MP0003646_muscle_fatigue0.83333979
97MP0008995_early_reproductive_senescence0.83227436
98MP0003953_abnormal_hormone_level0.83195943
99MP0005448_abnormal_energy_balance0.82367435
100MP0004147_increased_porphyrin_level0.81976245
101MP0005535_abnormal_body_temperature0.81634750
102MP0005584_abnormal_enzyme/coenzyme_acti0.79797656
103MP0003183_abnormal_peptide_metabolism0.79639066
104MP0008775_abnormal_heart_ventricle0.78137926
105MP0009840_abnormal_foam_cell0.77495268
106MP0002118_abnormal_lipid_homeostasis0.77441735
107MP0002089_abnormal_postnatal_growth/wei0.77128656
108MP0000639_abnormal_adrenal_gland0.76032459
109MP0000462_abnormal_digestive_system0.73315377
110MP0000747_muscle_weakness0.73256348
111MP0003879_abnormal_hair_cell0.72715312
112MP0005083_abnormal_biliary_tract0.71816487
113MP0005620_abnormal_muscle_contractility0.71604022
114MP0003718_maternal_effect0.71039523
115MP0002282_abnormal_trachea_morphology0.70503568
116MP0001324_abnormal_eye_pigmentation0.70161423
117MP0005195_abnormal_posterior_eye0.69511402
118MP0005167_abnormal_blood-brain_barrier0.69248299
119MP0003045_fibrosis0.68865005
120MP0005646_abnormal_pituitary_gland0.68803701
121MP0004145_abnormal_muscle_electrophysio0.68085948
122MP0002557_abnormal_social/conspecific_i0.67760482
123MP0002876_abnormal_thyroid_physiology0.66914912
124MP0003122_maternal_imprinting0.66638564
125MP0000371_diluted_coat_color0.66161308
126MP0005408_hypopigmentation0.65700472
127MP0010030_abnormal_orbit_morphology0.65506090
128MP0005389_reproductive_system_phenotype0.64857047
129MP0003942_abnormal_urinary_system0.64769039
130MP0003121_genomic_imprinting0.64507557
131MP0002098_abnormal_vibrissa_morphology0.64343739
132MP0002269_muscular_atrophy0.64220411
133MP0000609_abnormal_liver_physiology0.62716604
134* MP0009642_abnormal_blood_homeostasis0.62466295
135MP0001293_anophthalmia0.62299518
136MP0000163_abnormal_cartilage_morphology0.61992510
137MP0009672_abnormal_birth_weight0.61497995
138MP0003315_abnormal_perineum_morphology0.61194626
139MP0004142_abnormal_muscle_tone0.61018866
140MP0003943_abnormal_hepatobiliary_system0.60507174
141MP0003786_premature_aging0.60218505
142MP0003566_abnormal_cell_adhesion0.59082160
143MP0009384_cardiac_valve_regurgitation0.57127653
144MP0001664_abnormal_digestion0.56332296
145MP0002108_abnormal_muscle_morphology0.54956332
146MP0003137_abnormal_impulse_conducting0.52851156
147MP0003795_abnormal_bone_structure0.52125084
148MP0000537_abnormal_urethra_morphology0.50877086
149MP0005385_cardiovascular_system_phenoty0.50398755
150MP0001544_abnormal_cardiovascular_syste0.50398755

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.81653298
2Hypokalemic alkalosis (HP:0001949)7.53561680
3Metabolic alkalosis (HP:0200114)7.16254354
4Hyperactive renin-angiotensin system (HP:0000841)7.00782999
5Hypomagnesemia (HP:0002917)6.40527964
6Polyuria (HP:0000103)6.30567260
7Gout (HP:0001997)6.07405567
8* Abnormality of chloride homeostasis (HP:0011422)5.90809783
9Abnormal urine output (HP:0012590)5.89936778
10Abnormality of magnesium homeostasis (HP:0004921)5.63999415
11Abnormality of renal excretion (HP:0011036)5.56656175
12Abnormality of renin-angiotensin system (HP:0000847)5.35274735
13Abnormal drinking behavior (HP:0030082)5.17900678
14Polydipsia (HP:0001959)5.17900678
15Hyperaldosteronism (HP:0000859)5.00586842
16Tetany (HP:0001281)4.95110207
17Renal salt wasting (HP:0000127)4.78732565
18Alkalosis (HP:0001948)4.72696972
19Hypokalemia (HP:0002900)4.58185602
20Ketoacidosis (HP:0001993)4.39109298
21Increased purine levels (HP:0004368)4.04130476
22Hyperuricemia (HP:0002149)4.04130476
23Proximal tubulopathy (HP:0000114)3.93456784
24Hypercalciuria (HP:0002150)3.76254524
25Prolonged partial thromboplastin time (HP:0003645)3.68271538
26Abnormality of purine metabolism (HP:0004352)3.50848044
27Deep venous thrombosis (HP:0002625)3.46586256
28* Abnormality of potassium homeostasis (HP:0011042)3.45314695
29Generalized aminoaciduria (HP:0002909)3.42233236
30Congenital stationary night blindness (HP:0007642)3.27891609
31Hypoglycemic coma (HP:0001325)3.25956613
32Hyperglycinuria (HP:0003108)3.25905853
33Ketosis (HP:0001946)3.25230600
34Hemorrhage of the eye (HP:0011885)3.25072940
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.11052135
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.04950168
37Decreased circulating renin level (HP:0003351)2.84295960
38Testicular atrophy (HP:0000029)2.83976315
39Adrenal overactivity (HP:0002717)2.83579547
40Hyperinsulinemic hypoglycemia (HP:0000825)2.83311985
41Glycosuria (HP:0003076)2.80644368
42Abnormality of urine glucose concentration (HP:0011016)2.80644368
43Late onset (HP:0003584)2.74050808
44Cystic liver disease (HP:0006706)2.72730376
45Metaphyseal cupping (HP:0003021)2.71437153
46Abnormality of fatty-acid metabolism (HP:0004359)2.70246433
47Pendular nystagmus (HP:0012043)2.69159492
48Hypophosphatemic rickets (HP:0004912)2.63823097
49Nephrocalcinosis (HP:0000121)2.62636724
50Hypoglycemic seizures (HP:0002173)2.61999002
51Mesangial abnormality (HP:0001966)2.61718568
52Hyperphosphaturia (HP:0003109)2.58853687
53Symptomatic seizures (HP:0011145)2.57577016
54Abnormality of sodium homeostasis (HP:0010931)2.57224007
55Aplasia/Hypoplasia of the patella (HP:0006498)2.56883321
56Patellar aplasia (HP:0006443)2.56164773
57Joint hemorrhage (HP:0005261)2.55242292
58Abnormality of calcium-phosphate metabolism (HP:0100530)2.54106125
59Abnormality of glycine metabolism (HP:0010895)2.53078604
60Abnormality of serine family amino acid metabolism (HP:0010894)2.53078604
61Hyponatremia (HP:0002902)2.52129721
62Renal tubular acidosis (HP:0001947)2.51865222
63Attenuation of retinal blood vessels (HP:0007843)2.50601212
64Abnormal urine phosphate concentration (HP:0012599)2.48008891
65Rib fusion (HP:0000902)2.47583618
66Abnormality of the nasal septum (HP:0000419)2.44186796
67Ileus (HP:0002595)2.44148886
68Abnormality of the vitreous humor (HP:0004327)2.41744580
69Hypophosphatemia (HP:0002148)2.41661247
70Delayed epiphyseal ossification (HP:0002663)2.40586851
71Xanthomatosis (HP:0000991)2.38309799
72Birth length less than 3rd percentile (HP:0003561)2.38069309
73Abnormality of the renal cortex (HP:0011035)2.34118128
74Type II lissencephaly (HP:0007260)2.29255994
75Hypotension (HP:0002615)2.29140546
76Abnormality of nucleobase metabolism (HP:0010932)2.27269006
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27002932
78Nephrolithiasis (HP:0000787)2.26481838
79Severe muscular hypotonia (HP:0006829)2.23942350
80Abnormality of midbrain morphology (HP:0002418)2.22806245
81Molar tooth sign on MRI (HP:0002419)2.22806245
82Pancreatic cysts (HP:0001737)2.21410904
83Hydroxyprolinuria (HP:0003080)2.21084447
84Abnormality of proline metabolism (HP:0010907)2.21084447
85Chondrocalcinosis (HP:0000934)2.18442255
86Abnormal pancreas size (HP:0012094)2.18376551
87Dehydration (HP:0001944)2.16721310
88Protrusio acetabuli (HP:0003179)2.16555267
89Hypobetalipoproteinemia (HP:0003563)2.13893917
90Thin bony cortex (HP:0002753)2.12054975
91Poikiloderma (HP:0001029)2.08253874
92Abnormality of the renal medulla (HP:0100957)2.06061153
93Lymphangioma (HP:0100764)2.05523376
94Truncus arteriosus (HP:0001660)2.03821363
95Increased corneal curvature (HP:0100692)2.03368612
96Keratoconus (HP:0000563)2.03368612
97Nephronophthisis (HP:0000090)2.02641503
98Abnormality of Sharpey fibers (HP:0100685)2.02024828
99Vaginal fistula (HP:0004320)2.01060675
100Hyperglycemia (HP:0003074)1.99872892
101Breast hypoplasia (HP:0003187)1.97671500
102Widely patent fontanelles and sutures (HP:0004492)1.97579511
103Hyperthyroidism (HP:0000836)1.96973345
104Pancreatic islet-cell hyperplasia (HP:0004510)1.96778638
105Enlarged kidneys (HP:0000105)1.95677601
106Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94878226
107Dicarboxylic aciduria (HP:0003215)1.92503252
108Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92503252
109Potter facies (HP:0002009)1.92476880
110Facial shape deformation (HP:0011334)1.92476880
111Pancreatic fibrosis (HP:0100732)1.92398264
112Abnormality of DNA repair (HP:0003254)1.91693434
113Rectal prolapse (HP:0002035)1.90960348
114Abnormality of alanine metabolism (HP:0010916)1.90809270
115Hyperalaninemia (HP:0003348)1.90809270
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90809270
117Glomerulosclerosis (HP:0000096)1.89149775
118Chronic hepatic failure (HP:0100626)1.87768902
119Rickets (HP:0002748)1.86759756
120Tubular atrophy (HP:0000092)1.86662661
121Vascular calcification (HP:0004934)1.85826464
122Duplicated collecting system (HP:0000081)1.83971145
123J-shaped sella turcica (HP:0002680)1.83751571
124Chorioretinal atrophy (HP:0000533)1.83694354
125Generalized muscle weakness (HP:0003324)1.81596698
126Tachypnea (HP:0002789)1.81100497
127Abnormal enzyme/coenzyme activity (HP:0012379)1.79428248
128Metabolic acidosis (HP:0001942)1.79408223
129Vomiting (HP:0002013)1.79004868
130Increased number of teeth (HP:0011069)1.78686364
131Abnormality of alkaline phosphatase activity (HP:0004379)1.78463677
132Cerebellar dysplasia (HP:0007033)1.78297681
133Delayed CNS myelination (HP:0002188)1.78078887
134Abnormality of the aortic arch (HP:0012303)1.77927418
135Protuberant abdomen (HP:0001538)1.77636251
136Unilateral renal agenesis (HP:0000122)1.77581820
137Abnormality of endocrine pancreas physiology (HP:0012093)1.76096070
138Abnormality of the pancreatic islet cells (HP:0006476)1.76096070
139Premature rupture of membranes (HP:0001788)1.76040175
140True hermaphroditism (HP:0010459)1.75423583
141Tubulointerstitial fibrosis (HP:0005576)1.73397114
142Broad alveolar ridges (HP:0000187)1.73078643
143Hyperglycinemia (HP:0002154)1.72459574
144Hypoplasia of the pons (HP:0012110)1.72235837
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71723112
146Absent epiphyses (HP:0010577)1.71723112
147Dysostosis multiplex (HP:0000943)1.71085295
148Pigmentary retinal degeneration (HP:0001146)1.71078637
149Abnormality of renal resorption (HP:0011038)1.69594692
150Abnormality of the pons (HP:0007361)1.67334869
151Enlarged epiphyses (HP:0010580)1.67153266
152Cardiovascular calcification (HP:0011915)1.67012953
153Bulbous nose (HP:0000414)1.66745903
154Hyperphosphatemia (HP:0002905)1.65927549
155Squamous cell carcinoma (HP:0002860)1.65738680
156Arthropathy (HP:0003040)1.64441993
157Intestinal fistula (HP:0100819)1.63751794
158Occipital encephalocele (HP:0002085)1.63690976
159Hyperammonemia (HP:0001987)1.63490084
160Microretrognathia (HP:0000308)1.63488199
161Bicornuate uterus (HP:0000813)1.63039370
162Hand muscle atrophy (HP:0009130)1.62927838
163Rectal fistula (HP:0100590)1.62811544
164Rectovaginal fistula (HP:0000143)1.62811544
165Abnormality of the wing of the ilium (HP:0011867)1.62723715
166Bronchomalacia (HP:0002780)1.60240087
167Mucopolysacchariduria (HP:0008155)1.59598371
168Urinary glycosaminoglycan excretion (HP:0003541)1.59598371
169Hyperparathyroidism (HP:0000843)1.59563227
170Bowed forearm bones (HP:0003956)1.58872403
171Bowing of the arm (HP:0006488)1.58872403
172Slender long bone (HP:0003100)1.58840984
173Abnormality of carpal bone ossification (HP:0006257)1.57797810
174Large for gestational age (HP:0001520)1.57679399
175Abnormality of dentin (HP:0010299)1.57121512
176Facial hemangioma (HP:0000329)1.57118545
177Decreased central vision (HP:0007663)1.56643500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.38392683
2* WNK46.33287789
3OXSR15.74673303
4STK393.96033746
5MAP2K62.76860237
6BMPR1B2.52284725
7INSRR2.48972379
8MAPK152.47420710
9ADRBK22.46752128
10ACVR1B2.37038783
11BCKDK2.36828093
12TLK12.31141026
13NEK22.30734437
14NME12.22506822
15TRIB32.07579838
16AKT32.05040474
17ZAK1.98624456
18PIK3CA1.97292698
19EEF2K1.94093702
20STK38L1.91127714
21MAPKAPK31.85530471
22ERN11.81150868
23TYRO31.71269448
24GRK11.64672180
25PDK31.55870224
26PDK41.55870224
27PRKD31.47262638
28SIK21.46587487
29NTRK31.44305534
30MAP4K21.42795009
31FRK1.42605735
32MST1R1.39667033
33MAPKAPK51.38709196
34SGK4941.35610270
35SGK2231.35610270
36MAP3K21.35387177
37PAK31.22138189
38PTK61.20462939
39PASK1.17423957
40PTK21.17215238
41PNCK1.16008195
42LATS11.13678881
43DAPK21.10836613
44DYRK1B1.10585194
45PIK3CG1.06595535
46EPHB11.03901561
47NEK11.03290095
48TRPM71.00916483
49SGK20.96548131
50SGK30.96546979
51PDGFRA0.96375626
52FGFR40.96089666
53ADRBK10.94604896
54FER0.93464817
55LMTK20.93346654
56PDK20.93319630
57PKN20.92985751
58BRSK20.92135329
59STK380.91549586
60FGFR30.88007045
61TIE10.86979973
62RIPK10.85901522
63MET0.84743396
64TTN0.84123956
65MAP3K30.82308114
66WEE10.80570636
67FGFR20.79549199
68PRKD20.78490087
69MUSK0.77088038
70EPHB20.76654807
71TGFBR10.73047839
72PRKAA10.73006222
73SIK10.72013620
74TAOK30.71613414
75MYLK0.71155543
76LRRK20.70813704
77FGFR10.69945688
78GSK3A0.69598787
79MAP2K20.69281219
80MAP3K10.68684352
81CDC42BPA0.68119134
82EPHA20.66338093
83HIPK20.65988743
84TGFBR20.62607408
85MAPK130.60526327
86CDK120.58018822
87PRKCI0.57093686
88CASK0.56437965
89NTRK10.56087896
90PAK40.55877122
91PRKCH0.55604544
92MTOR0.55290606
93IRAK30.52967733
94EIF2AK10.52552254
95MAP3K70.51071965
96RPS6KA20.48813455
97CSNK1E0.47558711
98EPHA30.43035931
99KSR20.43029342
100TTK0.42629804
101PRKD10.42585884
102BMX0.41492703
103UHMK10.41020954
104CHEK20.40864546
105CAMKK20.40807003
106PRKCG0.40558889
107PDPK10.39517483
108CAMK1G0.38904910
109PRKAA20.38373779
110CDK80.36571002
111DDR20.35501949
112BRSK10.35188702
113MAPK80.34781973
114RPS6KA60.34640440
115TAOK10.34480585
116FLT30.33515688
117PRKG20.32560529
118RET0.32445546
119MAP2K10.31451166
120AKT10.30375980
121CAMK10.29322712
122CDK10.28650117
123ICK0.28329603
124* SGK10.28261640
125PRKACG0.26911908
126PINK10.25839254
127TESK10.25444298
128ROCK10.24568321
129PTK2B0.23138051
130CAMK1D0.23017150
131MAPK110.22627561
132ERBB20.22093024
133DMPK0.19068476
134PHKG20.18757364
135PHKG10.18757364
136MARK20.17409029
137PDGFRB0.17392376
138MAP3K100.16966337
139PRKACA0.16265899
140JAK20.15761680
141CAMK2D0.15590857
142PRKCE0.15551850
143MST40.15070356
144PRKCZ0.13834563
145PAK20.13184740
146CSNK1A10.11630345

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.91961017
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.29261309
3Butanoate metabolism_Homo sapiens_hsa006503.05202620
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.98786039
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.92390699
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.83461356
7Propanoate metabolism_Homo sapiens_hsa006402.70760443
8Sulfur relay system_Homo sapiens_hsa041222.65139284
9Sulfur metabolism_Homo sapiens_hsa009202.61008061
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59292748
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53249332
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51415144
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39697372
14Fatty acid degradation_Homo sapiens_hsa000712.36789966
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29454397
16Tryptophan metabolism_Homo sapiens_hsa003802.10868718
17Pyruvate metabolism_Homo sapiens_hsa006201.95361510
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.93256563
19Complement and coagulation cascades_Homo sapiens_hsa046101.93092712
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92725712
21One carbon pool by folate_Homo sapiens_hsa006701.85400752
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83410248
23Collecting duct acid secretion_Homo sapiens_hsa049661.82293840
24Steroid biosynthesis_Homo sapiens_hsa001001.80771509
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80335718
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.79122862
27Protein digestion and absorption_Homo sapiens_hsa049741.74646152
28Peroxisome_Homo sapiens_hsa041461.71278819
29Fatty acid metabolism_Homo sapiens_hsa012121.65283520
30Lysine degradation_Homo sapiens_hsa003101.63928521
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58514399
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51837191
33Fatty acid biosynthesis_Homo sapiens_hsa000611.50260328
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50054340
35Bile secretion_Homo sapiens_hsa049761.46591272
36Carbon metabolism_Homo sapiens_hsa012001.44760296
37Linoleic acid metabolism_Homo sapiens_hsa005911.44711832
38beta-Alanine metabolism_Homo sapiens_hsa004101.37698458
39Selenocompound metabolism_Homo sapiens_hsa004501.36290364
40Vitamin digestion and absorption_Homo sapiens_hsa049771.35937277
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32044931
42Other glycan degradation_Homo sapiens_hsa005111.31146143
43Mineral absorption_Homo sapiens_hsa049781.27786285
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26146012
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20852148
46Insulin secretion_Homo sapiens_hsa049111.20482745
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19494627
48Phototransduction_Homo sapiens_hsa047441.17523590
49Retinol metabolism_Homo sapiens_hsa008301.16561558
50Starch and sucrose metabolism_Homo sapiens_hsa005001.15655975
51Ether lipid metabolism_Homo sapiens_hsa005651.14860153
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11410572
53Arginine and proline metabolism_Homo sapiens_hsa003301.10723927
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06125812
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04196087
56PPAR signaling pathway_Homo sapiens_hsa033201.02593781
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02135598
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98979199
59Thyroid hormone synthesis_Homo sapiens_hsa049180.98046330
60Vibrio cholerae infection_Homo sapiens_hsa051100.96797892
61Glutathione metabolism_Homo sapiens_hsa004800.94979674
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.94885632
63Fanconi anemia pathway_Homo sapiens_hsa034600.94684922
64Chemical carcinogenesis_Homo sapiens_hsa052040.93861269
65Caffeine metabolism_Homo sapiens_hsa002320.92870811
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90335442
67Phenylalanine metabolism_Homo sapiens_hsa003600.90188866
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89867536
69Protein export_Homo sapiens_hsa030600.89341055
70Folate biosynthesis_Homo sapiens_hsa007900.88967326
71Homologous recombination_Homo sapiens_hsa034400.86715806
72Lysosome_Homo sapiens_hsa041420.85902347
73Basal transcription factors_Homo sapiens_hsa030220.85388631
74Taste transduction_Homo sapiens_hsa047420.83956406
75Fructose and mannose metabolism_Homo sapiens_hsa000510.77809544
76Arginine biosynthesis_Homo sapiens_hsa002200.77129263
77Oxidative phosphorylation_Homo sapiens_hsa001900.76671840
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76268728
79Renin-angiotensin system_Homo sapiens_hsa046140.75516040
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.74846875
81Insulin resistance_Homo sapiens_hsa049310.74476706
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72073564
83Cardiac muscle contraction_Homo sapiens_hsa042600.71772935
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69968983
85Histidine metabolism_Homo sapiens_hsa003400.69442514
86Gastric acid secretion_Homo sapiens_hsa049710.68597514
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67643221
88Bladder cancer_Homo sapiens_hsa052190.67513067
89ABC transporters_Homo sapiens_hsa020100.66074613
90Pancreatic secretion_Homo sapiens_hsa049720.64306290
91Biosynthesis of amino acids_Homo sapiens_hsa012300.63934500
92Glucagon signaling pathway_Homo sapiens_hsa049220.63667516
93Glycerolipid metabolism_Homo sapiens_hsa005610.60208536
94Type II diabetes mellitus_Homo sapiens_hsa049300.59366891
95Nitrogen metabolism_Homo sapiens_hsa009100.55576271
96RNA polymerase_Homo sapiens_hsa030200.54799393
97Parkinsons disease_Homo sapiens_hsa050120.54070931
98Ovarian steroidogenesis_Homo sapiens_hsa049130.52915417
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52526504
100Fatty acid elongation_Homo sapiens_hsa000620.50071286
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48004934
102Vitamin B6 metabolism_Homo sapiens_hsa007500.46019646
103ECM-receptor interaction_Homo sapiens_hsa045120.44409870
104Dilated cardiomyopathy_Homo sapiens_hsa054140.42010832
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41759507
106Arachidonic acid metabolism_Homo sapiens_hsa005900.41195505
107AMPK signaling pathway_Homo sapiens_hsa041520.41125194
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39608097
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.39125429
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.38577028
111Fat digestion and absorption_Homo sapiens_hsa049750.37157530
112Nicotine addiction_Homo sapiens_hsa050330.36951698
113Tight junction_Homo sapiens_hsa045300.36607264
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.36009748
115Metabolic pathways_Homo sapiens_hsa011000.35672644
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35108065
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33629024
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33626401
119Basal cell carcinoma_Homo sapiens_hsa052170.33509753
120Galactose metabolism_Homo sapiens_hsa000520.33148965
121Cocaine addiction_Homo sapiens_hsa050300.32877680
122Tyrosine metabolism_Homo sapiens_hsa003500.32506155
123Alzheimers disease_Homo sapiens_hsa050100.32268136
124Focal adhesion_Homo sapiens_hsa045100.32080844
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31952868
126N-Glycan biosynthesis_Homo sapiens_hsa005100.31383747
127Circadian rhythm_Homo sapiens_hsa047100.29914882
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.26267822
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25602512
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25380805
131Sphingolipid metabolism_Homo sapiens_hsa006000.23737614
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.22951799
133Insulin signaling pathway_Homo sapiens_hsa049100.22833654
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22274078
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21149513
136Adherens junction_Homo sapiens_hsa045200.21024018
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21007074
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18398482

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