WNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung epithelium development (GO:0060428)9.07770535
2glomerular filtration (GO:0003094)8.29124069
3renal filtration (GO:0097205)7.35621893
4glomerular basement membrane development (GO:0032836)6.84309413
5positive regulation of tolerance induction (GO:0002645)6.76499635
6regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.01207858
7regulation of tolerance induction (GO:0002643)5.98818984
8establishment of apical/basal cell polarity (GO:0035089)5.85981159
9glomerular epithelial cell development (GO:0072310)5.83017377
10* spinal cord association neuron differentiation (GO:0021527)5.72070349
11tolerance induction (GO:0002507)5.57082473
12negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)5.48529950
13positive regulation of gastrulation (GO:2000543)5.42935091
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.39887927
15establishment of tissue polarity (GO:0007164)5.33276857
16establishment of planar polarity (GO:0001736)5.33276857
17pattern specification involved in kidney development (GO:0061004)5.21667989
18establishment or maintenance of monopolar cell polarity (GO:0061339)5.17786815
19establishment of monopolar cell polarity (GO:0061162)5.17786815
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.16448370
21dendritic spine morphogenesis (GO:0060997)5.14131609
22negative regulation of cell fate specification (GO:0009996)5.05052130
23dopaminergic neuron differentiation (GO:0071542)5.00663719
24chondrocyte development (GO:0002063)5.00094657
25negative regulation of immunoglobulin mediated immune response (GO:0002890)4.91528896
26negative regulation of B cell mediated immunity (GO:0002713)4.91528896
27retinal ganglion cell axon guidance (GO:0031290)4.78962455
28leukocyte aggregation (GO:0070486)4.78480074
29negative regulation of humoral immune response (GO:0002921)4.73419211
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.72752085
31negative regulation of cell killing (GO:0031342)4.72752085
32negative thymic T cell selection (GO:0045060)4.70319378
33negative T cell selection (GO:0043383)4.56899002
34astrocyte differentiation (GO:0048708)4.53935476
35positive regulation of gamma-delta T cell activation (GO:0046645)4.53593434
36negative regulation of T cell differentiation in thymus (GO:0033085)4.49034004
37histamine secretion (GO:0001821)4.42439968
38face development (GO:0060324)4.37422096
39axon extension involved in axon guidance (GO:0048846)4.33458222
40neuron projection extension involved in neuron projection guidance (GO:1902284)4.33458222
41negative regulation of axon extension involved in axon guidance (GO:0048843)4.28628057
42lung lobe morphogenesis (GO:0060463)4.26157841
43regulation of T-helper 1 cell differentiation (GO:0045625)4.23048117
44interferon-gamma secretion (GO:0072643)4.21605577
45axonal fasciculation (GO:0007413)4.21341395
46T cell migration (GO:0072678)4.17978154
47negative regulation of axon guidance (GO:1902668)4.16441949
48neuronal stem cell maintenance (GO:0097150)4.14437715
49epithelial cell differentiation involved in prostate gland development (GO:0060742)4.13506476
50regulation of chronic inflammatory response (GO:0002676)4.07733704
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.06785059
52insulin-like growth factor receptor signaling pathway (GO:0048009)4.05873204
53positive regulation of BMP signaling pathway (GO:0030513)4.05791802
54nephron tubule morphogenesis (GO:0072078)4.05171168
55nephron epithelium morphogenesis (GO:0072088)4.05171168
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.03845247
57branching involved in labyrinthine layer morphogenesis (GO:0060670)4.03430493
58lens fiber cell development (GO:0070307)4.01808680
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.97666242
60NLS-bearing protein import into nucleus (GO:0006607)3.95374528
61regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.90572046
62telencephalon development (GO:0021537)3.88760314
63negative regulation of interleukin-12 production (GO:0032695)3.85225057
64neuronal action potential propagation (GO:0019227)3.85025665
65positive regulation of catenin import into nucleus (GO:0035413)3.75254182
66positive regulation of cell fate commitment (GO:0010455)3.74505007
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.73680931
68negative regulation of embryonic development (GO:0045992)3.69000760
69innervation (GO:0060384)3.68595994
70cranial suture morphogenesis (GO:0060363)3.64840489
71thymic T cell selection (GO:0045061)3.63342922
72positive regulation of insulin receptor signaling pathway (GO:0046628)3.63265864
73negative regulation of oligodendrocyte differentiation (GO:0048715)3.61302890
74negative regulation of smooth muscle cell migration (GO:0014912)3.60315163
75regulation of chemokine-mediated signaling pathway (GO:0070099)3.59576752
76regulation of collateral sprouting (GO:0048670)3.58864414
77* midbrain development (GO:0030901)3.58260879
78negative regulation of thymocyte apoptotic process (GO:0070244)3.56545679
79T cell selection (GO:0045058)3.55075457
80negative regulation of leukocyte chemotaxis (GO:0002689)3.54995402
81V(D)J recombination (GO:0033151)3.53876497
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52096873
83regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.51967184
84response to muramyl dipeptide (GO:0032495)3.51668377
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51154649
86* neuron fate determination (GO:0048664)3.50659356
87positive regulation of cardiac muscle cell differentiation (GO:2000727)3.50032355
88pathway-restricted SMAD protein phosphorylation (GO:0060389)3.50020363
89ectoderm development (GO:0007398)3.49467339
90regulation of T cell tolerance induction (GO:0002664)3.48548477
91cell proliferation in forebrain (GO:0021846)3.48207114
92type I interferon signaling pathway (GO:0060337)3.45748784
93cellular response to type I interferon (GO:0071357)3.45748784
94paraxial mesoderm development (GO:0048339)3.43569871
95positive regulation of B cell proliferation (GO:0030890)3.43349190
96regulation of somitogenesis (GO:0014807)3.43347087
97regulation of oligodendrocyte differentiation (GO:0048713)3.41976950
98collecting duct development (GO:0072044)3.40935304
99response to type I interferon (GO:0034340)3.39433525
100post-anal tail morphogenesis (GO:0036342)3.39024357
101segment specification (GO:0007379)3.38865325
102positive thymic T cell selection (GO:0045059)3.37704801
103positive T cell selection (GO:0043368)3.35593898
104regulation of gamma-delta T cell activation (GO:0046643)3.33103333
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31432710
106antigen processing and presentation of endogenous antigen (GO:0019883)3.31090923
107heart valve formation (GO:0003188)3.30915637
108positive regulation of oligodendrocyte differentiation (GO:0048714)3.30161032
109negative regulation of cell fate commitment (GO:0010454)3.29879605
110radial glial cell differentiation (GO:0060019)3.29610117
111establishment or maintenance of apical/basal cell polarity (GO:0035088)3.26477079
112establishment or maintenance of bipolar cell polarity (GO:0061245)3.26477079
113negative regulation of cytokine production involved in immune response (GO:0002719)3.26362627
114thalamus development (GO:0021794)3.26020624
115regulation of cardioblast differentiation (GO:0051890)3.25983681
116histamine transport (GO:0051608)3.25790441
117microtubule depolymerization (GO:0007019)3.25709987
118endocardial cushion morphogenesis (GO:0003203)3.25558615
119epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.24890668
120negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.24391832
121regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23193819
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23115765
123cellular response to ethanol (GO:0071361)3.20679386
124dorsal/ventral neural tube patterning (GO:0021904)3.18735969
125germinal center formation (GO:0002467)3.15707587
126regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.13989535
127planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13843380
128* hematopoietic stem cell proliferation (GO:0071425)3.12956501
129negative regulation of T cell mediated immunity (GO:0002710)3.11858052
130myeloid dendritic cell differentiation (GO:0043011)3.11810092
131dendritic spine organization (GO:0097061)3.11480368
132anatomical structure arrangement (GO:0048532)3.08581418
133cell surface receptor signaling pathway involved in heart development (GO:0061311)3.06876680
134renal tubule morphogenesis (GO:0061333)3.06185759
135lateral sprouting from an epithelium (GO:0060601)3.05673640
136regulation of vitamin D biosynthetic process (GO:0060556)3.02070700
137stress granule assembly (GO:0034063)2.98210646
138regulation of T-helper 2 cell differentiation (GO:0045628)2.97726961
139embryonic foregut morphogenesis (GO:0048617)2.97077350
140regulation of interleukin-2 biosynthetic process (GO:0045076)2.96863068
141axon ensheathment in central nervous system (GO:0032291)2.96656283
142central nervous system myelination (GO:0022010)2.96656283
143urogenital system development (GO:0001655)2.96247942
144positive regulation of B cell activation (GO:0050871)2.96173303
145regulation of cytokine secretion involved in immune response (GO:0002739)2.96139914
146heparan sulfate proteoglycan metabolic process (GO:0030201)2.95833440
147left/right pattern formation (GO:0060972)2.95071108
148negative chemotaxis (GO:0050919)2.95000449
149retina layer formation (GO:0010842)2.94530007
150neuronal ion channel clustering (GO:0045161)2.93008703
151ear development (GO:0043583)2.92133028
152cell fate commitment involved in formation of primary germ layer (GO:0060795)2.91865928
153branching involved in salivary gland morphogenesis (GO:0060445)2.91174815
154detection of other organism (GO:0098543)2.90790329
155defense response to protozoan (GO:0042832)2.90025392
156myeloid dendritic cell activation (GO:0001773)2.89524439
157negative regulation of alpha-beta T cell activation (GO:0046636)2.89006017
158regulation of B cell proliferation (GO:0030888)2.88764332
159mesenchyme morphogenesis (GO:0072132)2.88447450
160regulation of establishment of planar polarity (GO:0090175)2.87815615
161fat-soluble vitamin biosynthetic process (GO:0042362)2.87322165
162atrioventricular valve morphogenesis (GO:0003181)2.86716264
163Notch signaling involved in heart development (GO:0061314)2.86147632
164gland morphogenesis (GO:0022612)2.85687833
165neuron recognition (GO:0008038)2.85550957
166neutrophil activation involved in immune response (GO:0002283)2.84868037
167detection of bacterium (GO:0016045)2.83923848
168regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.83302004
169regulation of axon guidance (GO:1902667)2.83258153
170cellular response to ATP (GO:0071318)2.80517459
171B cell proliferation (GO:0042100)2.80364980
172regulation of interferon-alpha production (GO:0032647)2.80111363
173T cell lineage commitment (GO:0002360)2.80088131
174positive regulation by symbiont of host defense response (GO:0052509)2.79945171
175modulation by symbiont of host defense response (GO:0052031)2.79945171
176modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79945171
177modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79945171
178positive regulation by organism of defense response of other organism involved in symbiotic interact2.79945171
179modulation by symbiont of host immune response (GO:0052553)2.79945171
180NIK/NF-kappaB signaling (GO:0038061)2.79599503
181regulation of gamma-delta T cell differentiation (GO:0045586)2.77616771
182negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77418694
183T cell homeostasis (GO:0043029)2.76810430
184immunoglobulin mediated immune response (GO:0016064)2.76672089
185axis elongation (GO:0003401)2.76416218
186response to peptidoglycan (GO:0032494)2.76391523
187* positive regulation of embryonic development (GO:0040019)2.75461458
188regulation of alpha-beta T cell differentiation (GO:0046637)2.74818063
189macrophage activation involved in immune response (GO:0002281)2.74296355
190regulation of T-helper cell differentiation (GO:0045622)2.74173947
191response to interleukin-15 (GO:0070672)2.73633374
192signal complex assembly (GO:0007172)2.72719921
193negative regulation of lymphocyte mediated immunity (GO:0002707)2.72625372
194interferon-gamma production (GO:0032609)2.72286758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.40172441
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.96981111
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.93412720
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.53183593
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.70760716
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.55314738
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14044310
8GATA1_22025678_ChIP-Seq_K562_Human3.12052278
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.98324086
10E2F7_22180533_ChIP-Seq_HELA_Human2.97242559
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.94510382
12RUNX_20019798_ChIP-Seq_JUKART_Human2.89972819
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87535481
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.76720870
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.75436815
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.66601833
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.63544693
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.59949895
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.58318898
20* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57286235
21* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57286235
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.55799581
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.54532175
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.53608291
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50887115
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.49870191
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.49870191
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.49870191
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.46246919
30* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.45837612
31AR_21572438_ChIP-Seq_LNCaP_Human2.44794053
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42228744
33* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42020168
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40279053
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38819056
36* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34800971
37* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29293678
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26738460
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24934886
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23671565
41ESR1_21235772_ChIP-Seq_MCF-7_Human2.17664384
42* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17534137
43* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.17333370
44VDR_21846776_ChIP-Seq_THP-1_Human2.15888235
45MAF_26560356_Chip-Seq_TH1_Human2.13194187
46KDM2B_26808549_Chip-Seq_DND41_Human2.11946296
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.10905468
48ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10183819
49TCF7_22412390_ChIP-Seq_EML_Mouse2.10032656
50* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09569692
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07468539
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07256307
53* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06534909
54MYC_22102868_ChIP-Seq_BL_Human2.06501987
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05699637
56TRIM28_21343339_ChIP-Seq_HEK293_Human2.05229553
57AHR_22903824_ChIP-Seq_MCF-7_Human1.98081858
58SPI1_23127762_ChIP-Seq_K562_Human1.95836721
59UTX_26944678_Chip-Seq_JUKART_Human1.92234131
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.90964347
61MYB_26560356_Chip-Seq_TH2_Human1.89395699
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87141734
63SCL_19346495_ChIP-Seq_HPC-7_Human1.86452744
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.85267550
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82295815
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81878319
67* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81058426
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80460962
69* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80095078
70TAF15_26573619_Chip-Seq_HEK293_Human1.79435091
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79340484
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.78817417
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77693955
74VDR_24763502_ChIP-Seq_THP-1_Human1.77507507
75* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76538641
76* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72829531
77* KDM2B_26808549_Chip-Seq_JURKAT_Human1.72090732
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70228424
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69112425
80EZH2_22144423_ChIP-Seq_EOC_Human1.67403346
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64533893
82DROSHA_22980978_ChIP-Seq_HELA_Human1.64288697
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62758346
84* MAF_26560356_Chip-Seq_TH2_Human1.61113918
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57342018
86* EZH2_27294783_Chip-Seq_ESCs_Mouse1.56569130
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.55264392
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.54695255
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.53114330
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52085588
91GATA3_27048872_Chip-Seq_THYMUS_Human1.51549807
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46654464
93MYB_26560356_Chip-Seq_TH1_Human1.46259521
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44622332
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.44329729
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44272147
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.44182416
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41140795
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39205328
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37786049
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37279150
102* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36699848
103* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36325481
104* TP53_20018659_ChIP-ChIP_R1E_Mouse1.36147105
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36056418
106* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33609821
107* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33520033
108* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32737397
109* CBX2_27304074_Chip-Seq_ESCs_Mouse1.29664975
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29502097
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.28961291
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28329160
113VDR_24787735_ChIP-Seq_THP-1_Human1.28316177
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24423267
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24416428
116SPI1_23547873_ChIP-Seq_NB4_Human1.21396255
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21279056
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18929450
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18552172
120* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15153022
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.14030727
122CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13857999
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.13658623
124NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10392551
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09869249
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.09358233
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08471264
128CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08118339
129* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07234107
130GATA1_19941826_ChIP-Seq_K562_Human1.06361933
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06342880
132TP53_16413492_ChIP-PET_HCT116_Human1.05275130
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04544833
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03845571
135EWS_26573619_Chip-Seq_HEK293_Human1.03633145
136AR_19668381_ChIP-Seq_PC3_Human1.03422742
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01578739
138PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01287146
139CDX2_20551321_ChIP-Seq_CACO-2_Human1.00505302
140SOX2_16153702_ChIP-ChIP_HESCs_Human1.00168901
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99834000
142CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99610692
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99250143
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99032323
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99009272
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97454695
147LXR_22292898_ChIP-Seq_THP-1_Human0.97402121
148STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97282312
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.97003904
150EGR1_19032775_ChIP-ChIP_M12_Human0.96711713
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96595182
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96240628
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95516772
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.95340226
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94282984
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92781823
157TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92664329
158P300_19829295_ChIP-Seq_ESCs_Human0.92169026
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.91574673
160* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91034564
161STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90963823
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.90224770
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89810459
164FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88622517
165* KDM2B_26808549_Chip-Seq_K562_Human0.86477806
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85737236
167SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85306851
168SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85262478
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85173712
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82574474
171CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82316249
172RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82270253
173PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81287563
174* PU_27001747_Chip-Seq_BMDM_Mouse0.80965701
175TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77620719
176SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77504255
177PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77195933
178* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75639393
179PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75556912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.78908928
2MP0000566_synostosis4.30850622
3MP0004510_myositis3.96551884
4MP0000467_abnormal_esophagus_morphology3.86295946
5MP0005076_abnormal_cell_differentiation3.48301345
6MP0006082_CNS_inflammation3.47632234
7MP0002282_abnormal_trachea_morphology3.46137255
8MP0003436_decreased_susceptibility_to3.37754093
9MP0009278_abnormal_bone_marrow3.37120920
10MP0005671_abnormal_response_to3.34128378
11MP0003724_increased_susceptibility_to3.33142219
12MP0003283_abnormal_digestive_organ3.06202382
13MP0000537_abnormal_urethra_morphology2.92702806
14MP0001835_abnormal_antigen_presentation2.85651404
15MP0002938_white_spotting2.85171790
16MP0004947_skin_inflammation2.72177807
17MP0001790_abnormal_immune_system2.70249727
18MP0005387_immune_system_phenotype2.70249727
19MP0009785_altered_susceptibility_to2.67444179
20MP0004381_abnormal_hair_follicle2.57446350
21MP0005000_abnormal_immune_tolerance2.53417080
22MP0001800_abnormal_humoral_immune2.49422433
23MP0000383_abnormal_hair_follicle2.43078422
24MP0000778_abnormal_nervous_system2.40830622
25MP0002653_abnormal_ependyma_morphology2.23805690
26MP0002751_abnormal_autonomic_nervous2.22299115
27MP0002148_abnormal_hypersensitivity_rea2.21919008
28MP0005451_abnormal_body_composition2.21353004
29MP0000462_abnormal_digestive_system2.21248446
30MP0003763_abnormal_thymus_physiology2.17786363
31MP0003942_abnormal_urinary_system2.17535488
32MP0002933_joint_inflammation2.15954621
33MP0010678_abnormal_skin_adnexa2.14584968
34MP0001533_abnormal_skeleton_physiology2.14244464
35MP0000579_abnormal_nail_morphology2.09912832
36MP0001346_abnormal_lacrimal_gland2.07362840
37MP0005025_abnormal_response_to2.03561497
38MP0003880_abnormal_central_pattern2.02637288
39MP0002723_abnormal_immune_serum2.00061374
40MP0002419_abnormal_innate_immunity1.99759500
41* MP0002249_abnormal_larynx_morphology1.95730118
42MP0002132_abnormal_respiratory_system1.95031052
43MP0002452_abnormal_antigen_presenting1.93927167
44MP0010155_abnormal_intestine_physiology1.93653037
45MP0000685_abnormal_immune_system1.92987683
46MP0001873_stomach_inflammation1.90231286
47MP0002234_abnormal_pharynx_morphology1.87735309
48MP0002932_abnormal_joint_morphology1.84072766
49MP0002405_respiratory_system_inflammati1.81354253
50MP0002420_abnormal_adaptive_immunity1.76372182
51MP0001819_abnormal_immune_cell1.76136077
52MP0004133_heterotaxia1.74492059
53MP0003315_abnormal_perineum_morphology1.73804536
54MP0004264_abnormal_extraembryonic_tissu1.73602073
55MP0001881_abnormal_mammary_gland1.73348017
56MP0001545_abnormal_hematopoietic_system1.68464853
57MP0005397_hematopoietic_system_phenotyp1.68464853
58MP0001529_abnormal_vocalization1.68459175
59MP0001293_anophthalmia1.67687874
60MP0008961_abnormal_basal_metabolism1.67385006
61MP0003122_maternal_imprinting1.65806354
62MP0009384_cardiac_valve_regurgitation1.62306357
63MP0005381_digestive/alimentary_phenotyp1.57982417
64MP0002092_abnormal_eye_morphology1.56823024
65MP0003938_abnormal_ear_development1.56161415
66MP0002998_abnormal_bone_remodeling1.54230760
67MP0002102_abnormal_ear_morphology1.51190359
68MP0002098_abnormal_vibrissa_morphology1.50258168
69MP0002396_abnormal_hematopoietic_system1.46612599
70MP0001188_hyperpigmentation1.45962857
71MP0009053_abnormal_anal_canal1.45070568
72MP0001851_eye_inflammation1.44957550
73MP0005248_abnormal_Harderian_gland1.39614503
74* MP0002398_abnormal_bone_marrow1.38779134
75* MP0000716_abnormal_immune_system1.37329632
76MP0010030_abnormal_orbit_morphology1.36329308
77MP0000647_abnormal_sebaceous_gland1.36039638
78MP0001663_abnormal_digestive_system1.35718281
79MP0001849_ear_inflammation1.33661330
80* MP0002116_abnormal_craniofacial_bone1.30552297
81MP0010234_abnormal_vibrissa_follicle1.30489804
82MP0001845_abnormal_inflammatory_respons1.28198514
83MP0009333_abnormal_splenocyte_physiolog1.28072884
84MP0002089_abnormal_postnatal_growth/wei1.28000075
85MP0001299_abnormal_eye_distance/1.27086474
86* MP0000703_abnormal_thymus_morphology1.25584352
87MP0002111_abnormal_tail_morphology1.25235389
88MP0002896_abnormal_bone_mineralization1.25134786
89* MP0000026_abnormal_inner_ear1.22589150
90* MP0003861_abnormal_nervous_system1.21939000
91MP0008057_abnormal_DNA_replication1.20641815
92MP0002233_abnormal_nose_morphology1.20282060
93MP0008004_abnormal_stomach_pH1.18198906
94MP0002877_abnormal_melanocyte_morpholog1.17113215
95MP0001177_atelectasis1.16439891
96MP0000631_abnormal_neuroendocrine_gland1.16337860
97MP0003121_genomic_imprinting1.16283408
98MP0005508_abnormal_skeleton_morphology1.16167432
99MP0000427_abnormal_hair_cycle1.13526175
100MP0000534_abnormal_ureter_morphology1.13378723
101MP0002722_abnormal_immune_system1.12210607
102MP0001853_heart_inflammation1.12156758
103MP0000490_abnormal_crypts_of1.11990246
104MP0005390_skeleton_phenotype1.10981050
105MP0004197_abnormal_fetal_growth/weight/1.10364604
106* MP0000163_abnormal_cartilage_morphology1.10327291
107MP0003172_abnormal_lysosome_physiology1.10192141
108MP0005670_abnormal_white_adipose1.10008276
109MP0002184_abnormal_innervation1.07894356
110MP0004233_abnormal_muscle_weight1.04297331
111MP0000689_abnormal_spleen_morphology1.02666850
112MP0000377_abnormal_hair_follicle1.01224993
113MP0005058_abnormal_lysosome_morphology1.00905003
114MP0001324_abnormal_eye_pigmentation1.00023839
115MP0008469_abnormal_protein_level0.99496894
116MP0003690_abnormal_glial_cell0.98769785
117MP0005075_abnormal_melanosome_morpholog0.98225555
118MP0003075_altered_response_to0.97407912
119MP0003115_abnormal_respiratory_system0.97383802
120MP0000428_abnormal_craniofacial_morphol0.97288594
121* MP0002429_abnormal_blood_cell0.94690307
122MP0002796_impaired_skin_barrier0.93116551
123MP0000955_abnormal_spinal_cord0.92125088
124MP0000762_abnormal_tongue_morphology0.91692592
125MP0002332_abnormal_exercise_endurance0.91034323
126MP0001286_abnormal_eye_development0.90760966
127MP0004883_abnormal_blood_vessel0.90323613
128* MP0004742_abnormal_vestibular_system0.89741903
129MP0003453_abnormal_keratinocyte_physiol0.88845771
130MP0003755_abnormal_palate_morphology0.88167382
131* MP0002152_abnormal_brain_morphology0.87123355
132MP0004859_abnormal_synaptic_plasticity0.86149176
133* MP0002085_abnormal_embryonic_tissue0.84400009
134MP0003828_pulmonary_edema0.83794611
135MP0000432_abnormal_head_morphology0.83579202
136MP0001501_abnormal_sleep_pattern0.83529984
137MP0005023_abnormal_wound_healing0.83392245
138MP0009764_decreased_sensitivity_to0.83325067
139MP0000627_abnormal_mammary_gland0.82927330
140MP0004808_abnormal_hematopoietic_stem0.82650285
141MP0005171_absent_coat_pigmentation0.81968984
142MP0005377_hearing/vestibular/ear_phenot0.81083058
143MP0003878_abnormal_ear_physiology0.81083058
144MP0000350_abnormal_cell_proliferation0.80569794
145MP0003045_fibrosis0.80261735
146MP0004885_abnormal_endolymph0.80040618
147MP0000569_abnormal_digit_pigmentation0.79992566
148MP0005391_vision/eye_phenotype0.79401310
149MP0001943_abnormal_respiration0.79384362
150MP0005310_abnormal_salivary_gland0.79112444
151MP0002697_abnormal_eye_size0.77277513
152MP0003136_yellow_coat_color0.76717358
153MP0002081_perinatal_lethality0.76539542
154MP0003091_abnormal_cell_migration0.75207877
155MP0005623_abnormal_meninges_morphology0.74100656
156MP0003300_gastrointestinal_ulcer0.73994256
157MP0003634_abnormal_glial_cell0.73590813
158MP0003448_altered_tumor_morphology0.73267542
159MP0003937_abnormal_limbs/digits/tail_de0.70166672
160MP0000604_amyloidosis0.69805773
161MP0002075_abnormal_coat/hair_pigmentati0.69682576
162MP0005220_abnormal_exocrine_pancreas0.69532539
163MP0000465_gastrointestinal_hemorrhage0.68680617
164MP0000858_altered_metastatic_potential0.67936200
165MP0009840_abnormal_foam_cell0.59319420
166MP0005464_abnormal_platelet_physiology0.56939882
167MP0000733_abnormal_muscle_development0.56317418
168MP0003879_abnormal_hair_cell0.55275224
169MP0003795_abnormal_bone_structure0.54989917
170MP0002277_abnormal_respiratory_mucosa0.52965460
171MP0003866_abnormal_defecation0.51974415
172MP0002113_abnormal_skeleton_development0.51537055
173MP0003632_abnormal_nervous_system0.48852093
174MP0005666_abnormal_adipose_tissue0.46667838
175MP0005167_abnormal_blood-brain_barrier0.44810678
176MP0005166_decreased_susceptibility_to0.43441019
177MP0002166_altered_tumor_susceptibility0.42868137
178MP0001542_abnormal_bone_strength0.39023655
179MP0004858_abnormal_nervous_system0.38592255
180MP0002138_abnormal_hepatobiliary_system0.37775016
181MP0002876_abnormal_thyroid_physiology0.37091962

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)6.70588877
2B lymphocytopenia (HP:0010976)6.19416997
3Concave nail (HP:0001598)6.06987384
4Panhypogammaglobulinemia (HP:0003139)5.67893655
5T lymphocytopenia (HP:0005403)5.66850899
6Combined immunodeficiency (HP:0005387)5.59607457
7Abnormality of B cell number (HP:0010975)5.55689254
8Hypoplasia of the thymus (HP:0000778)4.95083606
9Abnormality of T cell number (HP:0011839)4.78145138
10Thyroiditis (HP:0100646)4.72842270
11Retrobulbar optic neuritis (HP:0100654)4.50918855
12Optic neuritis (HP:0100653)4.50918855
13Eczematoid dermatitis (HP:0000976)4.34257750
14Myositis (HP:0100614)4.21488097
15Stomatitis (HP:0010280)4.20773051
16Orchitis (HP:0100796)4.19453869
17Eosinophilia (HP:0001880)3.96190778
18Sparse lateral eyebrow (HP:0005338)3.89236778
19Right ventricular cardiomyopathy (HP:0011663)3.81704284
20Anophthalmia (HP:0000528)3.73140399
21Aplasia cutis congenita (HP:0001057)3.73048365
22Granulocytopenia (HP:0001913)3.69176672
23Maternal diabetes (HP:0009800)3.69034701
24Hypoproteinemia (HP:0003075)3.57639541
25Abnormality of eosinophils (HP:0001879)3.41395348
26Recurrent fungal infections (HP:0002841)3.40206626
27Meningitis (HP:0001287)3.39065846
28Recurrent viral infections (HP:0004429)3.37725926
29Septo-optic dysplasia (HP:0100842)3.37341819
30Abnormality of the labia minora (HP:0012880)3.32702071
31Recurrent bacterial skin infections (HP:0005406)3.30718080
32Leukocytosis (HP:0001974)3.28167294
33Abnormality of macrophages (HP:0004311)3.25851423
34White forelock (HP:0002211)3.21341741
35Flat capital femoral epiphysis (HP:0003370)3.19029497
36Scanning speech (HP:0002168)3.17863932
37Infantile muscular hypotonia (HP:0008947)3.13336834
38Keratoconjunctivitis sicca (HP:0001097)3.10417209
39Abnormality of the proximal phalanges of the hand (HP:0009834)3.04757634
40Chronic otitis media (HP:0000389)2.99840091
41Fair hair (HP:0002286)2.99548248
42Bilateral microphthalmos (HP:0007633)2.99117415
43Increased number of teeth (HP:0011069)2.97069515
44Ankyloglossia (HP:0010296)2.96900806
45Recurrent abscess formation (HP:0002722)2.95037082
46Shallow orbits (HP:0000586)2.94565523
47Abnormal number of incisors (HP:0011064)2.90305427
48Exostoses (HP:0100777)2.88424686
49Growth hormone deficiency (HP:0000824)2.82650982
50Mesangial abnormality (HP:0001966)2.81830893
51Abnormality of the fingertips (HP:0001211)2.81608754
52Keratoconjunctivitis (HP:0001096)2.77252908
53Split foot (HP:0001839)2.73446802
54IgG deficiency (HP:0004315)2.72916827
55Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.72876242
56Tented upper lip vermilion (HP:0010804)2.67336160
57Synostosis of carpal bones (HP:0005048)2.66894553
58Abnormality of nail color (HP:0100643)2.66409803
59Deep philtrum (HP:0002002)2.64938923
60Mediastinal lymphadenopathy (HP:0100721)2.62555934
61Increased IgM level (HP:0003496)2.59610593
62Patchy hypopigmentation of hair (HP:0011365)2.59347681
63Abnormal sex determination (HP:0012244)2.54547569
64Sex reversal (HP:0012245)2.54547569
65Abnormality of the nasal septum (HP:0000419)2.53386628
66Sepsis (HP:0100806)2.52632191
67Abnormality of the phalanges of the hallux (HP:0010057)2.51624435
68Cerebral aneurysm (HP:0004944)2.51301301
69Elevated erythrocyte sedimentation rate (HP:0003565)2.51298712
70Abnormality of T cells (HP:0002843)2.50236094
71Nasal polyposis (HP:0100582)2.47737318
72Stomach cancer (HP:0012126)2.47702321
73Ulnar deviation of finger (HP:0009465)2.45778061
74Heterochromia iridis (HP:0001100)2.45137053
75Autoimmune hemolytic anemia (HP:0001890)2.44764069
76Fused cervical vertebrae (HP:0002949)2.44564739
77Partial duplication of the phalanx of hand (HP:0009999)2.44188588
78Morphological abnormality of the middle ear (HP:0008609)2.44112535
79Anal stenosis (HP:0002025)2.42407850
80Recurrent bronchitis (HP:0002837)2.41584577
81Oligodactyly (hands) (HP:0001180)2.40401844
82Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40101920
83Small epiphyses (HP:0010585)2.38089074
84Wide cranial sutures (HP:0010537)2.37685274
85Diaphragmatic weakness (HP:0009113)2.36370353
86Pustule (HP:0200039)2.36213312
87Recurrent gram-negative bacterial infections (HP:0005420)2.34469550
88Vasculitis (HP:0002633)2.34013535
89Increased IgE level (HP:0003212)2.32563568
90Partial duplication of thumb phalanx (HP:0009944)2.29443001
91Parakeratosis (HP:0001036)2.28799108
92Abnormal pancreas size (HP:0012094)2.28196264
93Aplasia/Hypoplasia of the sternum (HP:0006714)2.27555815
94Obstructive sleep apnea (HP:0002870)2.26126104
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25962095
96Chronic sinusitis (HP:0011109)2.23808726
97Cheekbone underdevelopment (HP:0010669)2.23802788
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.23760159
99Erythroderma (HP:0001019)2.23642695
100Encephalitis (HP:0002383)2.22152700
101Recurrent sinusitis (HP:0011108)2.22073360
102Hyperacusis (HP:0010780)2.21293505
103Truncus arteriosus (HP:0001660)2.20724834
104Abnormality of the distal phalanx of the thumb (HP:0009617)2.20648744
105Chin dimple (HP:0010751)2.19055866
106Abnormality of glycolipid metabolism (HP:0010969)2.16496248
107Abnormality of liposaccharide metabolism (HP:0010968)2.16496248
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.16496248
109Trigonocephaly (HP:0000243)2.16274783
110Widely patent fontanelles and sutures (HP:0004492)2.14294162
111Aplasia/Hypoplasia of the thymus (HP:0010515)2.13435739
112Abnormality of oral frenula (HP:0000190)2.11983590
113Neoplasm of the adrenal cortex (HP:0100641)2.11348737
114Short 4th metacarpal (HP:0010044)2.09267065
115Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09267065
116Rib fusion (HP:0000902)2.08295061
117Pulmonary infiltrates (HP:0002113)2.07880171
118Generalized hypopigmentation of hair (HP:0011358)2.06276935
119Autoimmune thrombocytopenia (HP:0001973)2.06231192
120Increased nuchal translucency (HP:0010880)2.06062252
121Genu valgum (HP:0002857)2.05568264
122Esophageal atresia (HP:0002032)2.05100600
123Abnormality of the parietal bone (HP:0002696)2.04256794
124Intestinal atresia (HP:0011100)2.03816069
125Cellulitis (HP:0100658)2.03266366
126Gastrointestinal infarctions (HP:0005244)2.02782386
127Abnormality of the nasal mucosa (HP:0000433)2.01632325
128Hematochezia (HP:0002573)1.99932222
129Prenatal maternal abnormality (HP:0002686)1.99899322
130Enlarged epiphyses (HP:0010580)1.99585600
131Narrow palate (HP:0000189)1.98049248
132Morphological abnormality of the inner ear (HP:0011390)1.96365850
133Thin bony cortex (HP:0002753)1.96216724
134Agammaglobulinemia (HP:0004432)1.95558262
135Papilloma (HP:0012740)1.95207021
136Verrucae (HP:0200043)1.95207021
137Nuclear cataract (HP:0100018)1.95045250
138Interstitial pulmonary disease (HP:0006530)1.94761606
139Lymphopenia (HP:0001888)1.94061949
140Abnormality of the right ventricle (HP:0001707)1.91018967
141Embryonal neoplasm (HP:0002898)1.89548215
142Delayed epiphyseal ossification (HP:0002663)1.89005716
143Abnormality of incisor morphology (HP:0011063)1.86557684
144Germ cell neoplasia (HP:0100728)1.85674322
145Abnormality of the upper arm (HP:0001454)1.84928570
146Abnormality of the anterior horn cell (HP:0006802)1.84865134
147Degeneration of anterior horn cells (HP:0002398)1.84865134
148Alacrima (HP:0000522)1.84297597
149Turricephaly (HP:0000262)1.84093558
150Recurrent otitis media (HP:0000403)1.83873369
151Glomerulosclerosis (HP:0000096)1.83787101
152Sleep apnea (HP:0010535)1.83489102
153Hypoplasia of the iris (HP:0007676)1.81742392
154Pseudobulbar signs (HP:0002200)1.81556943
155Obsessive-compulsive behavior (HP:0000722)1.81099591
156Renal duplication (HP:0000075)1.80603136
157Overgrowth (HP:0001548)1.79795013
158Nasolacrimal duct obstruction (HP:0000579)1.79371264
159Hypergammaglobulinemia (HP:0010702)1.79348254
160Absent septum pellucidum (HP:0001331)1.79233536
161Exotropia (HP:0000577)1.78249489
162Loss of speech (HP:0002371)1.77585482
163Supernumerary ribs (HP:0005815)1.77483748
164Gangrene (HP:0100758)1.77165939
165Broad thumb (HP:0011304)1.77123137
166Hypoplastic labia majora (HP:0000059)1.77067130
167Biliary tract neoplasm (HP:0100574)1.76879286
168Flat occiput (HP:0005469)1.76786632
169Obstructive lung disease (HP:0006536)1.76120745
170Chronic obstructive pulmonary disease (HP:0006510)1.76120745
171Overfolded helix (HP:0000396)1.74978857
172IgM deficiency (HP:0002850)1.74473631
173Thoracolumbar scoliosis (HP:0002944)1.73869744
174Abnormally folded helix (HP:0008544)1.73433097
175Patellar dislocation (HP:0002999)1.73411825
176Anosmia (HP:0000458)1.73095460
177Bowel incontinence (HP:0002607)1.72755708
178Oligodactyly (HP:0012165)1.72516466
179Abnormality of the thymus (HP:0000777)1.72437459
180Hypoplastic ischia (HP:0003175)1.72117856
181Colitis (HP:0002583)1.71701095
182Vesicoureteral reflux (HP:0000076)1.71021344
183Carpal bone hypoplasia (HP:0001498)1.69447302
184Abnormality of cells of the lymphoid lineage (HP:0012140)1.68949900
185Carpal synostosis (HP:0009702)1.68452854
186* Bone pain (HP:0002653)1.68119378
187Recurrent pneumonia (HP:0006532)1.67975613
188Triangular face (HP:0000325)1.67966876
189Focal segmental glomerulosclerosis (HP:0000097)1.67383658
190Spinal muscular atrophy (HP:0007269)1.67041802
191Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65408879
192Acne (HP:0001061)1.63319490
193Hemoptysis (HP:0002105)1.63212276
194Vitreoretinal degeneration (HP:0000655)1.62873497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK17.18384358
2SIK36.46925070
3KSR15.34655941
4EPHB24.12294380
5BCR4.02579397
6MAP4K13.90309944
7NTRK13.39430938
8PRPF4B2.98866105
9MATK2.71014465
10EIF2AK32.67131804
11TYK22.44967844
12RIPK42.41976620
13ERBB22.36725985
14TXK2.32545257
15NTRK22.21066575
16KIT2.04635322
17IRAK41.83679688
18MAP2K31.82741933
19MAP3K141.80461648
20MINK11.69579118
21RIPK11.69342734
22GRK71.65456821
23CHUK1.61838486
24ZAP701.56956359
25EIF2AK21.53056339
26TAOK21.52992050
27CSK1.51895750
28IKBKE1.51873661
29SYK1.50343270
30JAK31.48239877
31FGR1.40636798
32CAMKK21.39747173
33CSF1R1.35628101
34MAP3K31.35246293
35NLK1.34119461
36BLK1.33904977
37FES1.31193161
38MET1.30980321
39DDR21.30862463
40CAMKK11.30754456
41HCK1.30663872
42TAOK11.29602691
43TNIK1.28432686
44TBK11.28411514
45CAMK1G1.27757301
46MAP3K111.26251395
47FGFR31.22510052
48ITK1.19561644
49CDK121.18576254
50LCK1.18212488
51IRAK21.12481927
52CAMK1D1.10518857
53FGFR21.10140324
54SIK21.08184325
55IKBKB1.07987956
56UHMK11.07336611
57MAP3K131.05667123
58TGFBR21.04802865
59IRAK31.03179164
60LYN1.01795671
61MARK21.00602529
62JAK20.99988088
63MARK30.99841657
64ZAK0.97852909
65ROCK20.96658223
66MAPK70.95925610
67GRK60.95717909
68TNK20.95131948
69ERN10.94718544
70MOS0.91798477
71MARK10.89750828
72EPHA30.89729348
73MAPK150.89723987
74FER0.89072500
75PIM10.88870751
76MAP3K100.88295094
77MTOR0.87404321
78ICK0.86878049
79CDK30.86290562
80STK100.85250050
81DYRK1B0.85181707
82CDC42BPA0.84822630
83HIPK20.81509260
84CDK180.78806520
85DMPK0.78262028
86NEK10.73213773
87TRIB30.72805518
88MAP3K90.72000146
89NTRK30.71347197
90MAP3K70.69823320
91FGFR40.68355934
92STK110.68260783
93CDK40.67929265
94BRD40.67878068
95TTK0.66526249
96PTK20.64198252
97LATS20.63111288
98CDK60.62531353
99FYN0.61903822
100SRC0.58858286
101YES10.58581202
102CLK10.58084694
103PRKCZ0.57961602
104CDK190.57221294
105RPS6KC10.56488901
106RPS6KL10.56488901
107PDGFRB0.54855479
108ADRBK10.54830488
109BMX0.54602926
110BMPR20.52971839
111MST1R0.52537953
112PDK10.52136602
113EGFR0.51387198
114PLK30.51108892
115CSNK1A1L0.50097527
116EPHB10.50065575
117CDK140.49641355
118SMG10.49585980
119RPS6KA60.49455707
120PRKCE0.48800305
121LATS10.46083951
122SGK20.46034303
123TYRO30.45335839
124JAK10.45220196
125MKNK10.45052188
126PKN10.43192635
127KSR20.42607675
128EEF2K0.41951136
129MAPK40.41684388
130TTN0.40768873
131ATR0.40394733
132STK40.40331675
133CSNK1E0.39930612
134PTK60.39642157
135CDK150.39199863
136PAK30.37968353
137SGK2230.37714908
138SGK4940.37714908
139PRKCH0.37461472
140CDK50.37153448
141CSNK1G10.36885004
142BTK0.35466990
143MAP3K10.34832070
144CHEK20.34232343
145STK390.34192932
146CDK11A0.34057222
147MAP3K20.33787126
148STK30.33370635
149PIK3CA0.33344584
150PASK0.32871274
151CSNK1G30.32799201
152NEK60.32711149
153IRAK10.32202754
154CSNK1D0.30449082
155CAMK10.29471320
156EPHA40.29451870
157FGFR10.27707889
158PRKCD0.27098654
159PAK20.25495803
160CDK10.24542581
161ROCK10.23849670
162TSSK60.23767699
163PNCK0.22270942
164MAPK90.21826700
165INSR0.21164590
166PLK10.20875760
167RET0.20785052
168RPS6KA10.20738544
169PRKD10.20122792
170SGK30.19907926
171SGK10.19805153
172PAK40.19804409

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052173.78005665
2Primary immunodeficiency_Homo sapiens_hsa053403.34456798
3Notch signaling pathway_Homo sapiens_hsa043303.12003770
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69265420
5Chronic myeloid leukemia_Homo sapiens_hsa052202.55543817
6Osteoclast differentiation_Homo sapiens_hsa043802.51350607
7* Hippo signaling pathway_Homo sapiens_hsa043902.50367030
8Allograft rejection_Homo sapiens_hsa053302.47171600
9Axon guidance_Homo sapiens_hsa043602.35299588
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27694410
11Leishmaniasis_Homo sapiens_hsa051402.22325721
12Malaria_Homo sapiens_hsa051442.19819268
13Dorso-ventral axis formation_Homo sapiens_hsa043202.19143123
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.16857609
15ErbB signaling pathway_Homo sapiens_hsa040122.14442187
16Graft-versus-host disease_Homo sapiens_hsa053322.11405518
17Autoimmune thyroid disease_Homo sapiens_hsa053202.10833773
18Bladder cancer_Homo sapiens_hsa052192.06072909
19* Hedgehog signaling pathway_Homo sapiens_hsa043402.02687758
20* Melanogenesis_Homo sapiens_hsa049161.98549776
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.94157388
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89202560
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87528371
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86354400
25Vitamin B6 metabolism_Homo sapiens_hsa007501.85859518
26MicroRNAs in cancer_Homo sapiens_hsa052061.82817912
27B cell receptor signaling pathway_Homo sapiens_hsa046621.81051698
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79139952
29TNF signaling pathway_Homo sapiens_hsa046681.76290845
30Renal cell carcinoma_Homo sapiens_hsa052111.73298320
31Glioma_Homo sapiens_hsa052141.72971901
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.72150269
33Pancreatic cancer_Homo sapiens_hsa052121.71079336
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.70929356
35* Wnt signaling pathway_Homo sapiens_hsa043101.69420164
36Adherens junction_Homo sapiens_hsa045201.68186415
37Endometrial cancer_Homo sapiens_hsa052131.62642148
38Measles_Homo sapiens_hsa051621.60650135
39Non-small cell lung cancer_Homo sapiens_hsa052231.59248453
40Staphylococcus aureus infection_Homo sapiens_hsa051501.58438789
41Asthma_Homo sapiens_hsa053101.56919146
42Colorectal cancer_Homo sapiens_hsa052101.55775170
43African trypanosomiasis_Homo sapiens_hsa051431.55120264
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54170181
45Hematopoietic cell lineage_Homo sapiens_hsa046401.53012584
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.50174641
47Other glycan degradation_Homo sapiens_hsa005111.46386965
48Steroid biosynthesis_Homo sapiens_hsa001001.44552854
49Influenza A_Homo sapiens_hsa051641.43489886
50* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43261036
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.43252247
52Tuberculosis_Homo sapiens_hsa051521.43083690
53Type I diabetes mellitus_Homo sapiens_hsa049401.40213150
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.35469968
55Toxoplasmosis_Homo sapiens_hsa051451.34898657
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32818789
57Rheumatoid arthritis_Homo sapiens_hsa053231.32731676
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32177613
59Chemokine signaling pathway_Homo sapiens_hsa040621.31152064
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30111984
61Herpes simplex infection_Homo sapiens_hsa051681.29730501
62Pertussis_Homo sapiens_hsa051331.29287524
63Cell cycle_Homo sapiens_hsa041101.28529535
64Nicotine addiction_Homo sapiens_hsa050331.27393417
65Lysine degradation_Homo sapiens_hsa003101.27080827
66* Proteoglycans in cancer_Homo sapiens_hsa052051.25477246
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25389548
68Thyroid cancer_Homo sapiens_hsa052161.24557473
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20468241
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19691701
71Prolactin signaling pathway_Homo sapiens_hsa049171.18975191
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18561061
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09176277
74Type II diabetes mellitus_Homo sapiens_hsa049301.08723283
75Antigen processing and presentation_Homo sapiens_hsa046121.05802447
76Legionellosis_Homo sapiens_hsa051341.05342519
77Salmonella infection_Homo sapiens_hsa051321.02268950
78Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02007105
79Hepatitis C_Homo sapiens_hsa051601.00659076
80Choline metabolism in cancer_Homo sapiens_hsa052310.96793265
81* Pathways in cancer_Homo sapiens_hsa052000.94951008
82Estrogen signaling pathway_Homo sapiens_hsa049150.94950325
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86780220
84Melanoma_Homo sapiens_hsa052180.86576429
85Prostate cancer_Homo sapiens_hsa052150.85757711
86Tryptophan metabolism_Homo sapiens_hsa003800.84842041
87Epstein-Barr virus infection_Homo sapiens_hsa051690.83757428
88Viral myocarditis_Homo sapiens_hsa054160.82799124
89* HTLV-I infection_Homo sapiens_hsa051660.81514515
90Small cell lung cancer_Homo sapiens_hsa052220.81210473
91Nitrogen metabolism_Homo sapiens_hsa009100.80467715
92Apoptosis_Homo sapiens_hsa042100.77579841
93Acute myeloid leukemia_Homo sapiens_hsa052210.77478048
94Gap junction_Homo sapiens_hsa045400.76429863
95Tight junction_Homo sapiens_hsa045300.76172642
96Prion diseases_Homo sapiens_hsa050200.76084618
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75113608
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73683677
99Oocyte meiosis_Homo sapiens_hsa041140.70112805
100Lysosome_Homo sapiens_hsa041420.69908122
101Cocaine addiction_Homo sapiens_hsa050300.69455993
102TGF-beta signaling pathway_Homo sapiens_hsa043500.69250378
103Long-term depression_Homo sapiens_hsa047300.67188605
104Phagosome_Homo sapiens_hsa041450.66823749
105Hepatitis B_Homo sapiens_hsa051610.65524349
106Fatty acid elongation_Homo sapiens_hsa000620.65353036
107FoxO signaling pathway_Homo sapiens_hsa040680.63090816
108Oxytocin signaling pathway_Homo sapiens_hsa049210.63034143
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.62844723
110Circadian entrainment_Homo sapiens_hsa047130.62086530
111AMPK signaling pathway_Homo sapiens_hsa041520.62055274
112Focal adhesion_Homo sapiens_hsa045100.61990584
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.61782065
114VEGF signaling pathway_Homo sapiens_hsa043700.61438768
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61248994
116Shigellosis_Homo sapiens_hsa051310.59707243
117Insulin signaling pathway_Homo sapiens_hsa049100.59489390
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.58321460
119Inositol phosphate metabolism_Homo sapiens_hsa005620.58220624
120Salivary secretion_Homo sapiens_hsa049700.58208416
121Vibrio cholerae infection_Homo sapiens_hsa051100.56452700
122mTOR signaling pathway_Homo sapiens_hsa041500.53194693
123Viral carcinogenesis_Homo sapiens_hsa052030.52276130
124Glutamatergic synapse_Homo sapiens_hsa047240.52025067
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51825470
126MAPK signaling pathway_Homo sapiens_hsa040100.51600574
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51205837
128Amoebiasis_Homo sapiens_hsa051460.51169419
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50003722
130Morphine addiction_Homo sapiens_hsa050320.48894107
131Ras signaling pathway_Homo sapiens_hsa040140.48473704
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45995252
133Collecting duct acid secretion_Homo sapiens_hsa049660.45989008
134GABAergic synapse_Homo sapiens_hsa047270.45181555
135Rap1 signaling pathway_Homo sapiens_hsa040150.44312347
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43935257
137Dilated cardiomyopathy_Homo sapiens_hsa054140.43825068
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.43270237
139Alcoholism_Homo sapiens_hsa050340.42095954
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42012803
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41392767
142Endocytosis_Homo sapiens_hsa041440.41048786
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40912266
144HIF-1 signaling pathway_Homo sapiens_hsa040660.39688894
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.37349987
146Systemic lupus erythematosus_Homo sapiens_hsa053220.36438758
147T cell receptor signaling pathway_Homo sapiens_hsa046600.36213298
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34986966
149Dopaminergic synapse_Homo sapiens_hsa047280.33565694
150Amphetamine addiction_Homo sapiens_hsa050310.33507128
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32962919
152Long-term potentiation_Homo sapiens_hsa047200.32378342
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.30695903
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30141378
155Cholinergic synapse_Homo sapiens_hsa047250.29846502

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