WNT10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.12863519
2molting cycle (GO:0042303)7.00260727
3hair cycle (GO:0042633)7.00260727
4cornea development in camera-type eye (GO:0061303)6.38288559
5positive regulation of odontogenesis (GO:0042482)6.10832246
6CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.07991137
7antigen processing and presentation of endogenous antigen (GO:0019883)5.86408960
8B cell receptor signaling pathway (GO:0050853)5.61207023
9negative regulation of glucose import (GO:0046325)5.53953926
10cell-substrate junction assembly (GO:0007044)5.49958380
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.47036884
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.47036884
13regulation of water loss via skin (GO:0033561)5.42057597
14keratinization (GO:0031424)5.36611875
15maternal placenta development (GO:0001893)5.31376384
16nephron tubule formation (GO:0072079)5.30359276
17T cell migration (GO:0072678)5.27473346
18B cell homeostasis (GO:0001782)5.20995728
19positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.10036904
20regulation of glucose import in response to insulin stimulus (GO:2001273)5.09367937
21immunoglobulin mediated immune response (GO:0016064)4.91919556
22regulation of B cell receptor signaling pathway (GO:0050855)4.85611145
23type I interferon signaling pathway (GO:0060337)4.82211468
24cellular response to type I interferon (GO:0071357)4.82211468
25response to type I interferon (GO:0034340)4.81682233
26establishment of skin barrier (GO:0061436)4.78039466
27viral transcription (GO:0019083)4.59712684
28T cell lineage commitment (GO:0002360)4.56146573
29T-helper 1 type immune response (GO:0042088)4.53689571
30negative regulation of glucose transport (GO:0010829)4.45826257
31negative thymic T cell selection (GO:0045060)4.44772253
32interferon-gamma-mediated signaling pathway (GO:0060333)4.43239619
33complement activation, classical pathway (GO:0006958)4.36736115
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.32527690
35translational termination (GO:0006415)4.31489613
36gonadal mesoderm development (GO:0007506)4.30470054
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.29048764
38regulation of interferon-gamma biosynthetic process (GO:0045072)4.26784523
39protein targeting to ER (GO:0045047)4.25474627
40positive regulation of Rho protein signal transduction (GO:0035025)4.24236930
41B cell proliferation (GO:0042100)4.23148487
42cotranslational protein targeting to membrane (GO:0006613)4.21643995
43intermediate filament organization (GO:0045109)4.18536120
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.18047467
45keratinocyte proliferation (GO:0043616)4.11687446
46keratinocyte development (GO:0003334)4.09589365
47establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09082586
48B cell mediated immunity (GO:0019724)4.08021091
49keratinocyte differentiation (GO:0030216)4.06461009
50bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06221921
51negative T cell selection (GO:0043383)4.03445413
52positive regulation of hair cycle (GO:0042635)3.98918864
53positive regulation of hair follicle development (GO:0051798)3.98918864
54positive regulation of humoral immune response (GO:0002922)3.97455656
55muscle organ morphogenesis (GO:0048644)3.94486077
56thymic T cell selection (GO:0045061)3.94470024
57protein localization to endoplasmic reticulum (GO:0070972)3.92766341
58regulation of hair follicle development (GO:0051797)3.90404441
59lung morphogenesis (GO:0060425)3.89753964
60hepatocyte apoptotic process (GO:0097284)3.88869303
61skin morphogenesis (GO:0043589)3.86622629
62regulation of protein heterodimerization activity (GO:0043497)3.84500390
63signal peptide processing (GO:0006465)3.83141269
64detection of bacterium (GO:0016045)3.82278958
65negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.81272541
66negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.79266287
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.76329593
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.73384541
69modulation by symbiont of host immune response (GO:0052553)3.73384541
70positive regulation by symbiont of host defense response (GO:0052509)3.73384541
71modulation by symbiont of host defense response (GO:0052031)3.73384541
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73384541
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73384541
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.72878420
75cell migration involved in gastrulation (GO:0042074)3.70771592
76apoptotic cell clearance (GO:0043277)3.70551519
77myeloid dendritic cell differentiation (GO:0043011)3.69923627
78ribosomal small subunit biogenesis (GO:0042274)3.67631839
79positive regulation of protein homooligomerization (GO:0032464)3.62257845
80translational elongation (GO:0006414)3.58522103
81cytoskeletal anchoring at plasma membrane (GO:0007016)3.56864781
82T cell costimulation (GO:0031295)3.56863999
83* skin development (GO:0043588)3.56337933
84exocrine pancreas development (GO:0031017)3.54210854
85regulation of alpha-beta T cell proliferation (GO:0046640)3.53699696
86lymphocyte costimulation (GO:0031294)3.53164346
87regulation of type I interferon-mediated signaling pathway (GO:0060338)3.48895180
88positive regulation of interferon-alpha production (GO:0032727)3.47728302
89negative regulation of B cell proliferation (GO:0030889)3.47284428
90multicellular organismal water homeostasis (GO:0050891)3.45419823
91positive regulation of gamma-delta T cell activation (GO:0046645)3.44031803
92lymphocyte migration (GO:0072676)3.42493559
93lymphocyte homeostasis (GO:0002260)3.42467094
94* regulation of odontogenesis (GO:0042481)3.42210365
95regulation of interferon-beta biosynthetic process (GO:0045357)3.41070935
96peptide cross-linking (GO:0018149)3.39524987
97cellular response to virus (GO:0098586)3.38278831
98cellular response to interferon-gamma (GO:0071346)3.35137299
99regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.35088560
100myeloid dendritic cell activation (GO:0001773)3.34944782
101response to muramyl dipeptide (GO:0032495)3.34906467
102cellular protein complex disassembly (GO:0043624)3.34316217
103positive regulation of B cell differentiation (GO:0045579)3.33421815
104positive regulation of histone deacetylation (GO:0031065)3.32042019
105complement activation (GO:0006956)3.31767231
106viral life cycle (GO:0019058)3.31288531
107planar cell polarity pathway involved in neural tube closure (GO:0090179)3.31225800
108* epidermis development (GO:0008544)3.30247684
109detection of other organism (GO:0098543)3.30246765
110intestinal epithelial cell development (GO:0060576)3.30103343
111positive regulation of B cell proliferation (GO:0030890)3.30000775
112establishment of tissue polarity (GO:0007164)3.29552070
113establishment of planar polarity (GO:0001736)3.29552070
114morphogenesis of embryonic epithelium (GO:0016331)3.29098100
115odontogenesis of dentin-containing tooth (GO:0042475)3.27844672
116germinal center formation (GO:0002467)3.26893790
117negative regulation of keratinocyte proliferation (GO:0010839)3.26847254
118positive regulation of alpha-beta T cell proliferation (GO:0046641)3.23394024
119endodermal cell differentiation (GO:0035987)3.23361244
120antimicrobial humoral response (GO:0019730)3.20708518
121nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20488212
122positive regulation of immunoglobulin mediated immune response (GO:0002891)3.19488286
123positive regulation of B cell mediated immunity (GO:0002714)3.19488286
124maturation of SSU-rRNA (GO:0030490)3.19212739
125regulation of interferon-alpha production (GO:0032647)3.19191483
126regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18886833
127positive regulation of protein oligomerization (GO:0032461)3.18531475
128protein targeting to membrane (GO:0006612)3.18224348
129* odontogenesis (GO:0042476)3.17518803
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15800369
131positive regulation of epidermis development (GO:0045684)3.15514182
132morphogenesis of an epithelial fold (GO:0060571)3.15261830
133regulation of B cell proliferation (GO:0030888)3.14886695
134negative regulation of myeloid cell apoptotic process (GO:0033033)3.13238747
135epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.13168624
136negative regulation of B cell apoptotic process (GO:0002903)3.12497573
137activation of MAPKKK activity (GO:0000185)3.12068978
138embryonic process involved in female pregnancy (GO:0060136)3.11536952
139antigen receptor-mediated signaling pathway (GO:0050851)3.11348205
140peptidyl-tyrosine autophosphorylation (GO:0038083)3.10693275
141regulation of interleukin-2 biosynthetic process (GO:0045076)3.09238309
142basement membrane organization (GO:0071711)3.08192676
143positive regulation of B cell activation (GO:0050871)3.08174136
144response to protozoan (GO:0001562)3.06038486
145NIK/NF-kappaB signaling (GO:0038061)3.04195763
146activation of Rac GTPase activity (GO:0032863)3.04012588
147negative regulation of phagocytosis (GO:0050765)3.02009552
148positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01733499
149adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.01064967
150regulation of B cell apoptotic process (GO:0002902)3.00787064
151negative regulation of T cell mediated immunity (GO:0002710)3.00216953
152antibacterial humoral response (GO:0019731)2.99712284
153regulation of hippo signaling (GO:0035330)2.99035864
154focal adhesion assembly (GO:0048041)2.98727592
155cell-substrate adherens junction assembly (GO:0007045)2.98727592
156regulation of antigen processing and presentation (GO:0002577)2.97370009
157modulation by symbiont of host cellular process (GO:0044068)2.96872631
158regulation of B cell differentiation (GO:0045577)2.96811961
159positive thymic T cell selection (GO:0045059)2.96037048
160regulation of B cell activation (GO:0050864)2.95857469
161positive regulation of cell killing (GO:0031343)2.95342461
162negative regulation of cell killing (GO:0031342)2.95298935
163negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95298935
164cellular response to interferon-beta (GO:0035458)2.92969223
165N-acetylneuraminate metabolic process (GO:0006054)2.91719563
166epidermal cell differentiation (GO:0009913)2.91244060
167T cell selection (GO:0045058)2.91173602
168production of molecular mediator of immune response (GO:0002440)2.91012547
169defense response to protozoan (GO:0042832)2.90930911
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90813229
171Fc-gamma receptor signaling pathway (GO:0038094)2.90545617
172Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.90545617
173immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.90545617
174positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90321498
175cellular response to antibiotic (GO:0071236)2.90218723
176cellular response to interleukin-15 (GO:0071350)2.89621454
177protein complex disassembly (GO:0043241)2.89336515
178ribosomal small subunit assembly (GO:0000028)2.87747007
179leukocyte homeostasis (GO:0001776)2.86981074
180response to interferon-gamma (GO:0034341)2.86086690
181Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.82664132
182apoptotic process involved in morphogenesis (GO:0060561)2.79511433
183polarized epithelial cell differentiation (GO:0030859)2.79471109
184translational initiation (GO:0006413)2.78375726
185wound healing, spreading of epidermal cells (GO:0035313)2.78030759
186atrioventricular valve morphogenesis (GO:0003181)2.76724276
187eyelid development in camera-type eye (GO:0061029)2.75634929
188adherens junction assembly (GO:0034333)2.73882690
189ribosomal large subunit biogenesis (GO:0042273)2.73782010
190regulation of hair cycle (GO:0042634)2.73671237
191antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69901226
192hemidesmosome assembly (GO:0031581)11.7386898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.77269411
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.20669605
3SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.13692240
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95485941
5* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.78663580
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62560488
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.51184386
8ZNF263_19887448_ChIP-Seq_K562_Human2.46839798
9CIITA_25753668_ChIP-Seq_RAJI_Human2.36604844
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.21456760
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11552410
12* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.09190006
13* LXR_22292898_ChIP-Seq_THP-1_Human2.07749405
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05500484
15RACK7_27058665_Chip-Seq_MCF-7_Human2.03479888
16TP63_17297297_ChIP-ChIP_HaCaT_Human14.4623557
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97897616
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97627255
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97365263
20MYB_26560356_Chip-Seq_TH1_Human1.95890809
21MYB_26560356_Chip-Seq_TH2_Human1.92883951
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.91695451
23* MYC_22102868_ChIP-Seq_BL_Human1.88779287
24MAF_26560356_Chip-Seq_TH2_Human1.84889928
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.83918745
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.83443906
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82101015
28E2F7_22180533_ChIP-Seq_HELA_Human1.80658239
29VDR_21846776_ChIP-Seq_THP-1_Human1.79240712
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.74644623
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74325541
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66339593
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.62807916
34KDM2B_26808549_Chip-Seq_K562_Human1.62607169
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62287081
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62223178
37HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.58291749
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57562075
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.57327600
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55915509
41* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54314933
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53551598
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53316769
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52737883
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51731343
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.51227273
47ATF3_27146783_Chip-Seq_COLON_Human1.50462216
48* KDM2B_26808549_Chip-Seq_DND41_Human1.49298855
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47395385
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45861367
51TP53_22127205_ChIP-Seq_IMR90_Human1.43579578
52* TP63_22573176_ChIP-Seq_HFKS_Human1.42585017
53* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41703993
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.40459965
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39675895
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39153329
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39153329
58TCF7_22412390_ChIP-Seq_EML_Mouse1.38924927
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.38452058
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.36217391
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34910007
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34425486
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33864717
64SPI1_23547873_ChIP-Seq_NB4_Human1.32989877
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.32938303
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32547844
67BCOR_27268052_Chip-Seq_Bcells_Human1.32316502
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31547478
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.31433653
70* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31299360
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31267303
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30979391
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30068987
74* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30065583
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30041751
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28096226
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26310296
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.24476168
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23041843
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22183254
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21980998
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21408869
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20933585
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20877698
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20543607
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19633016
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19081317
88RXR_22108803_ChIP-Seq_LS180_Human1.17485992
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16164262
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15735044
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.15229404
92MAF_26560356_Chip-Seq_TH1_Human1.14780122
93* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13529824
94* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12446397
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11620185
96GATA3_27048872_Chip-Seq_THYMUS_Human1.11235753
97SCL_19346495_ChIP-Seq_HPC-7_Human1.11063407
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10499169
99* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10001426
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09448247
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09017422
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08529829
103CDX2_20551321_ChIP-Seq_CACO-2_Human1.08398428
104UTX_26944678_Chip-Seq_JUKART_Human1.07682827
105E2F1_21310950_ChIP-Seq_MCF-7_Human1.07368280
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07190446
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06366098
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05440652
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04975844
110CTCF_27219007_Chip-Seq_Bcells_Human1.04552673
111RUNX_20019798_ChIP-Seq_JUKART_Human1.04223799
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04102688
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03127421
114MYC_18555785_ChIP-Seq_MESCs_Mouse1.02626830
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02611785
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02411099
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01414284
118NCOR1_26117541_ChIP-Seq_K562_Human1.00854895
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99740429
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99116159
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99116159
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99116159
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97927794
124MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97540799
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97356198
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96402325
127* P68_20966046_ChIP-Seq_HELA_Human0.96082746
128* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95474427
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.95429456
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94361179
131GATA1_22025678_ChIP-Seq_K562_Human0.94350754
132VDR_23849224_ChIP-Seq_CD4+_Human0.94126174
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.93582567
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92851012
135IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92717214
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92222397
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92219506
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92139479
139* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92113624
140SA1_27219007_Chip-Seq_Bcells_Human0.91177480
141HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91009621
142BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90367723
143KLF5_25053715_ChIP-Seq_YYC3_Human0.90132259
144SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89982714
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89466347
146SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89202471
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88487402
148* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88342137
149SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87413785
150BCL6_27268052_Chip-Seq_Bcells_Human0.86344427
151CREB1_26743006_Chip-Seq_LNCaP_Human0.85089361
152MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84851374
153SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83999362
154VDR_24763502_ChIP-Seq_THP-1_Human0.82779599
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81573867
156GATA6_25053715_ChIP-Seq_YYC3_Human0.80497904
157* ELF1_20517297_ChIP-Seq_JURKAT_Human0.80258215
158CTCF_21964334_Chip-Seq_Bcells_Human0.79918770
159SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78270993
160SMC4_20622854_ChIP-Seq_HELA_Human0.78153183
161CHD1_26751641_Chip-Seq_LNCaP_Human0.78082668
162* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78032111
163NOTCH1_21737748_ChIP-Seq_TLL_Human0.77892561
164* RNF2_27304074_Chip-Seq_ESCs_Mouse0.77410156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.75149793
2MP0002254_reproductive_system_inflammat5.57037267
3MP0002796_impaired_skin_barrier4.52325345
4MP0003705_abnormal_hypodermis_morpholog3.91433924
5MP0001346_abnormal_lacrimal_gland3.48482056
6MP0005275_abnormal_skin_tensile3.37240722
7MP0000579_abnormal_nail_morphology3.31964795
8MP0002060_abnormal_skin_morphology2.93755377
9MP0005645_abnormal_hypothalamus_physiol2.89152116
10MP0004264_abnormal_extraembryonic_tissu2.87835450
11MP0005501_abnormal_skin_physiology2.85865781
12MP0003453_abnormal_keratinocyte_physiol2.74013119
13MP0010678_abnormal_skin_adnexa2.71216823
14MP0002234_abnormal_pharynx_morphology2.69895716
15MP0001216_abnormal_epidermal_layer2.59288475
16MP0002098_abnormal_vibrissa_morphology2.55342438
17MP0000762_abnormal_tongue_morphology2.52777740
18MP0003941_abnormal_skin_development2.46495281
19MP0003183_abnormal_peptide_metabolism2.39597041
20MP0000383_abnormal_hair_follicle2.38916723
21MP0000467_abnormal_esophagus_morphology2.38782740
22MP0000427_abnormal_hair_cycle2.38541135
23MP0002398_abnormal_bone_marrow2.24985949
24MP0010771_integument_phenotype2.17360711
25MP0005025_abnormal_response_to2.14260129
26MP0000716_abnormal_immune_system2.10061326
27MP0003566_abnormal_cell_adhesion2.08728313
28MP0004947_skin_inflammation2.00756027
29MP0000377_abnormal_hair_follicle1.89795468
30MP0009785_altered_susceptibility_to1.89671472
31MP0001835_abnormal_antigen_presentation1.85422518
32MP0002148_abnormal_hypersensitivity_rea1.84858026
33MP0004381_abnormal_hair_follicle1.81320240
34MP0009333_abnormal_splenocyte_physiolog1.80692099
35MP0002429_abnormal_blood_cell1.72629000
36MP0002163_abnormal_gland_morphology1.72300969
37MP0000689_abnormal_spleen_morphology1.65666574
38MP0001191_abnormal_skin_condition1.65616207
39MP0001873_stomach_inflammation1.64164301
40MP0010030_abnormal_orbit_morphology1.62904075
41MP0005451_abnormal_body_composition1.60760684
42MP0009931_abnormal_skin_appearance1.60269444
43MP0002877_abnormal_melanocyte_morpholog1.57229521
44MP0010352_gastrointestinal_tract_polyps1.55731708
45MP0002722_abnormal_immune_system1.55636764
46MP0002006_tumorigenesis1.54816817
47MP0005023_abnormal_wound_healing1.54125293
48MP0001845_abnormal_inflammatory_respons1.49687225
49MP0001849_ear_inflammation1.47515627
50MP0000647_abnormal_sebaceous_gland1.44292451
51MP0002396_abnormal_hematopoietic_system1.43745591
52MP0001243_abnormal_dermal_layer1.41524051
53MP0000685_abnormal_immune_system1.37940589
54MP0001348_abnormal_lacrimal_gland1.35990784
55MP0002419_abnormal_innate_immunity1.35536093
56MP0005076_abnormal_cell_differentiation1.34432247
57MP0000703_abnormal_thymus_morphology1.33874347
58MP0008057_abnormal_DNA_replication1.33536486
59MP0001800_abnormal_humoral_immune1.32360871
60MP0004272_abnormal_basement_membrane1.32332502
61MP0001790_abnormal_immune_system1.25857896
62MP0005387_immune_system_phenotype1.25857896
63MP0005310_abnormal_salivary_gland1.25477907
64MP0000733_abnormal_muscle_development1.21713956
65MP0009053_abnormal_anal_canal1.16828703
66MP0000372_irregular_coat_pigmentation1.16713714
67MP0010094_abnormal_chromosome_stability1.16254971
68MP0002405_respiratory_system_inflammati1.15383177
69MP0001879_abnormal_lymphatic_vessel1.11781759
70MP0005075_abnormal_melanosome_morpholog1.05534857
71MP0008260_abnormal_autophagy1.05457205
72MP0001340_abnormal_eyelid_morphology1.03720545
73MP0000566_synostosis1.03330064
74MP0000490_abnormal_crypts_of1.02368397
75MP0008789_abnormal_olfactory_epithelium1.02164148
76MP0002019_abnormal_tumor_incidence1.01867627
77MP0003300_gastrointestinal_ulcer1.01547466
78MP0000367_abnormal_coat/_hair1.00546959
79MP0005464_abnormal_platelet_physiology0.98567367
80MP0008438_abnormal_cutaneous_collagen0.97503066
81MP0000678_abnormal_parathyroid_gland0.97465792
82MP0003763_abnormal_thymus_physiology0.90334203
83MP0002089_abnormal_postnatal_growth/wei0.89762974
84MP0000858_altered_metastatic_potential0.88499572
85MP0000750_abnormal_muscle_regeneration0.86189505
86MP0005248_abnormal_Harderian_gland0.85391627
87MP0004133_heterotaxia0.84631369
88MP0002452_abnormal_antigen_presenting0.82632392
89MP0000627_abnormal_mammary_gland0.81649019
90MP0000470_abnormal_stomach_morphology0.79681507
91MP0001851_eye_inflammation0.79345592
92MP0010155_abnormal_intestine_physiology0.78591021
93MP0003111_abnormal_nucleus_morphology0.78429930
94MP0002136_abnormal_kidney_physiology0.78206323
95MP0003303_peritoneal_inflammation0.77876604
96MP0005671_abnormal_response_to0.77807347
97MP0000003_abnormal_adipose_tissue0.76662481
98MP0002693_abnormal_pancreas_physiology0.76476838
99MP0008469_abnormal_protein_level0.76142520
100MP0003077_abnormal_cell_cycle0.76009278
101MP0005499_abnormal_olfactory_system0.75988547
102MP0005394_taste/olfaction_phenotype0.75988547
103MP0002138_abnormal_hepatobiliary_system0.75174558
104MP0003045_fibrosis0.72961262
105MP0005000_abnormal_immune_tolerance0.72875385
106MP0005623_abnormal_meninges_morphology0.72661949
107MP0001853_heart_inflammation0.72631033
108MP0004859_abnormal_synaptic_plasticity0.71874112
109MP0003693_abnormal_embryo_hatching0.71527890
110MP0002928_abnormal_bile_duct0.71463792
111MP0003091_abnormal_cell_migration0.69846141
112MP0000350_abnormal_cell_proliferation0.69432111
113MP0000537_abnormal_urethra_morphology0.68485662
114MP0002177_abnormal_outer_ear0.68458610
115MP0009643_abnormal_urine_homeostasis0.68278752
116MP0004043_abnormal_pH_regulation0.67732262
117MP0008007_abnormal_cellular_replicative0.65996075
118MP0003385_abnormal_body_wall0.65984498
119MP0005220_abnormal_exocrine_pancreas0.65320323
120MP0003436_decreased_susceptibility_to0.64144520
121MP0008874_decreased_physiological_sensi0.62569867
122MP0000371_diluted_coat_color0.62478033
123MP0002896_abnormal_bone_mineralization0.62411380
124MP0005379_endocrine/exocrine_gland_phen0.61862975
125MP0000428_abnormal_craniofacial_morphol0.61545737
126MP0001663_abnormal_digestive_system0.60765132
127MP0002111_abnormal_tail_morphology0.60530101
128MP0004858_abnormal_nervous_system0.59530832
129MP0000313_abnormal_cell_death0.59508321
130MP0002933_joint_inflammation0.59336195
131MP0002723_abnormal_immune_serum0.58052278
132MP0000477_abnormal_intestine_morphology0.56750555
133MP0000538_abnormal_urinary_bladder0.56571112
134MP0000465_gastrointestinal_hemorrhage0.56317646
135MP0000749_muscle_degeneration0.56160092
136MP0008569_lethality_at_weaning0.55812930
137MP0001727_abnormal_embryo_implantation0.55703499
138MP0002420_abnormal_adaptive_immunity0.55365072
139MP0001819_abnormal_immune_cell0.55166792
140MP0005621_abnormal_cell_physiology0.54347972
141MP0002166_altered_tumor_susceptibility0.52812518
142MP0000681_abnormal_thyroid_gland0.52386735
143MP0004510_myositis0.51983492
144MP0009379_abnormal_foot_pigmentation0.51857514
145MP0000751_myopathy0.51677902
146MP0003937_abnormal_limbs/digits/tail_de0.50180407
147MP0002233_abnormal_nose_morphology0.50072395
148MP0000613_abnormal_salivary_gland0.47692014
149MP0003866_abnormal_defecation0.47548410

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)8.22235450
2Atrophic scars (HP:0001075)6.55772428
3Fragile nails (HP:0001808)6.42791625
4IgM deficiency (HP:0002850)5.74615014
5* Onycholysis (HP:0001806)5.51610281
6IgA deficiency (HP:0002720)5.47708595
7* Plantar hyperkeratosis (HP:0007556)5.44922126
8* Nail dystrophy (HP:0008404)4.85352112
9Lymphopenia (HP:0001888)4.71674573
10Pili torti (HP:0003777)4.70009092
11Abnormality of cells of the lymphoid lineage (HP:0012140)4.54192779
12Agammaglobulinemia (HP:0004432)4.34762356
13* Hypotrichosis (HP:0001006)4.33813939
14Vasculitis (HP:0002633)4.10586947
15Fragile skin (HP:0001030)3.95780648
16Palmoplantar hyperkeratosis (HP:0000972)3.82852421
17Mediastinal lymphadenopathy (HP:0100721)3.82112749
18Colitis (HP:0002583)3.71163649
19B lymphocytopenia (HP:0010976)3.67693969
20Abnormality of B cell number (HP:0010975)3.67693969
21Verrucae (HP:0200043)3.67097405
22Papilloma (HP:0012740)3.67097405
23Right ventricular cardiomyopathy (HP:0011663)3.63116286
24Restrictive lung disease (HP:0002091)3.57051644
25Woolly hair (HP:0002224)3.56854949
26IgG deficiency (HP:0004315)3.53928213
27Abnormality of T cell physiology (HP:0011840)3.52070786
28Thick nail (HP:0001805)3.51252178
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.50830941
30Cellulitis (HP:0100658)3.50037537
31Palmar hyperkeratosis (HP:0010765)3.49194273
32Aplasia cutis congenita (HP:0001057)3.38654977
33Recurrent bronchitis (HP:0002837)3.27531663
34Abnormal blistering of the skin (HP:0008066)3.23595643
35Chronic diarrhea (HP:0002028)3.19103475
36Recurrent bacterial skin infections (HP:0005406)3.18276621
37Interstitial pulmonary disease (HP:0006530)3.17071596
38Recurrent otitis media (HP:0000403)3.11592821
39Gastrointestinal inflammation (HP:0004386)3.09277128
40Inflammation of the large intestine (HP:0002037)3.08638784
41Alopecia of scalp (HP:0002293)3.07575274
42Xerostomia (HP:0000217)3.06442257
43Panhypogammaglobulinemia (HP:0003139)3.04246142
44Recurrent sinusitis (HP:0011108)3.03634406
45Increased IgE level (HP:0003212)2.99334241
46Abnormality of the neuromuscular junction (HP:0003398)2.96247339
47Fatigable weakness (HP:0003473)2.96247339
48Eczematoid dermatitis (HP:0000976)2.95277426
49Abnormality of nail color (HP:0100643)2.95092693
50Chronic mucocutaneous candidiasis (HP:0002728)2.78136538
51Recurrent cutaneous fungal infections (HP:0011370)2.78136538
52Lymphoma (HP:0002665)2.77946726
53Down-sloping shoulders (HP:0200021)2.72316610
54Pterygium (HP:0001059)2.65617557
55Lip pit (HP:0100267)2.62569851
56Ureteral obstruction (HP:0006000)2.61327675
57Recurrent fungal infections (HP:0002841)2.61204547
58Trismus (HP:0000211)2.57763361
59Increased IgM level (HP:0003496)2.56059077
60Leukopenia (HP:0001882)2.56028436
61Poikiloderma (HP:0001029)2.55554620
62Abnormal hair laboratory examination (HP:0003328)2.54492820
63* Urticaria (HP:0001025)2.52712141
64Ankyloglossia (HP:0010296)2.52096624
65Autoimmune hemolytic anemia (HP:0001890)2.49732887
66* Skin rash (HP:0000988)2.48554941
67Premature rupture of membranes (HP:0001788)2.45918828
68Recurrent skin infections (HP:0001581)2.45522723
69Congenital ichthyosiform erythroderma (HP:0007431)2.43721703
70Skin ulcer (HP:0200042)2.42869151
71Chronic sinusitis (HP:0011109)2.42146806
72Hypertensive crisis (HP:0100735)2.42029460
73Pustule (HP:0200039)2.40678004
74Bronchiectasis (HP:0002110)2.38424798
75Obstructive lung disease (HP:0006536)2.37448057
76Chronic obstructive pulmonary disease (HP:0006510)2.37448057
77Hypoplasia of dental enamel (HP:0006297)2.37440496
78Chronic otitis media (HP:0000389)2.35742479
79Sepsis (HP:0100806)2.35222136
80Abnormality of T cells (HP:0002843)2.35112350
81Emphysema (HP:0002097)2.33114906
82Elevated erythrocyte sedimentation rate (HP:0003565)2.32387521
83Gastrointestinal stroma tumor (HP:0100723)2.29870175
84* Squamous cell carcinoma (HP:0002860)2.29415340
85* Ridged nail (HP:0001807)2.28123560
86Increased connective tissue (HP:0009025)2.27205312
87Distal lower limb amyotrophy (HP:0008944)2.27190397
88Hypokalemic alkalosis (HP:0001949)2.25508847
89Viral hepatitis (HP:0006562)2.21887012
90Unilateral renal agenesis (HP:0000122)2.21129733
91Dehydration (HP:0001944)2.20681532
92Abnormality of cells of the erythroid lineage (HP:0012130)2.20586028
93Natal tooth (HP:0000695)2.20279729
94Type 1 muscle fiber predominance (HP:0003803)2.16186217
95Recurrent pneumonia (HP:0006532)2.16080219
96Abnormality of macrophages (HP:0004311)2.15487329
97Lower limb amyotrophy (HP:0007210)2.14802540
98Amelogenesis imperfecta (HP:0000705)2.14524784
99Recurrent abscess formation (HP:0002722)2.13717185
100* Sparse scalp hair (HP:0002209)2.13177443
101Difficulty climbing stairs (HP:0003551)2.11093132
102Osteomyelitis (HP:0002754)2.09570400
103Esophageal atresia (HP:0002032)2.08806245
104Abnormality of the gastric mucosa (HP:0004295)2.07816455
105Pulmonary infiltrates (HP:0002113)2.06903064
106* Erythema (HP:0010783)2.05343107
107Curly hair (HP:0002212)2.04726050
108Hyperactive renin-angiotensin system (HP:0000841)2.01359175
109Abnormality of the prostate (HP:0008775)2.01072924
110Long palpebral fissure (HP:0000637)1.99897229
111Abnormality of oral frenula (HP:0000190)1.99194365
112Achilles tendon contracture (HP:0001771)1.97557106
113Round ear (HP:0100830)1.94284299
114Advanced eruption of teeth (HP:0006288)1.93775547
115Hepatitis (HP:0012115)1.91999229
116Arthralgia (HP:0002829)1.91932726
117Sparse lateral eyebrow (HP:0005338)1.90222459
118Ectropion (HP:0000656)1.87733657
119Villous atrophy (HP:0011473)1.87022464
120Abnormality of small intestinal villus morphology (HP:0011472)1.87022464
121* Hypohidrosis (HP:0000966)1.86031950
122* Basal cell carcinoma (HP:0002671)1.85051286
123Encephalitis (HP:0002383)1.84837997
124Neonatal short-limb short stature (HP:0008921)1.84416370
125Distal lower limb muscle weakness (HP:0009053)1.84269834
126* Anonychia (HP:0001798)1.82405918
127Oral leukoplakia (HP:0002745)1.82115122
128Shallow orbits (HP:0000586)1.81202985
129Cholecystitis (HP:0001082)1.81141631
130Abnormal gallbladder physiology (HP:0012438)1.81141631
131Neutropenia (HP:0001875)1.80759072
132Overlapping toe (HP:0001845)1.79925051
133Hypergammaglobulinemia (HP:0010702)1.77814294
134Abnormality of the fetal cardiovascular system (HP:0010948)1.77653886
135Abnormal umbilical cord blood vessels (HP:0011403)1.77653886
136Single umbilical artery (HP:0001195)1.77653886
137Ureteral stenosis (HP:0000071)1.77280490
138Recurrent lower respiratory tract infections (HP:0002783)1.77203002
139Malignant hyperthermia (HP:0002047)1.77176695
140Corneal erosion (HP:0200020)1.75543789
141Follicular hyperkeratosis (HP:0007502)1.74719190
142Abnormality of the Achilles tendon (HP:0005109)1.74091352
143Hyperkalemia (HP:0002153)1.69977649
144Pyloric stenosis (HP:0002021)1.67863725
145Popliteal pterygium (HP:0009756)1.67747694
146Meningitis (HP:0001287)1.66262080
147Mildly elevated creatine phosphokinase (HP:0008180)1.65338803
148Bronchitis (HP:0012387)1.65192717
149Abnormality of the umbilical cord (HP:0010881)1.64788058
150Protrusio acetabuli (HP:0003179)1.64030344
151Genu recurvatum (HP:0002816)1.63714518
152Abnormal hemoglobin (HP:0011902)1.63251491
153Recurrent viral infections (HP:0004429)1.62928618
154* Hyperhidrosis (HP:0000975)1.60448940
155Spinal rigidity (HP:0003306)1.59399609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.49936356
2ERN13.80731357
3SMG13.65064848
4PRPF4B3.57859632
5MAP3K93.37110313
6RIPK13.00761942
7MAP3K132.98754119
8ARAF2.91619760
9IRAK42.86088848
10MAPKAPK32.70722712
11VRK12.62462473
12NME22.40449945
13RPS6KB22.38442731
14TLK12.21910137
15TESK22.21234372
16KSR22.13641575
17BUB12.12746795
18CDK192.11926471
19TYK22.04067119
20RIPK42.01519088
21BLK1.98810136
22MAP4K11.95466928
23MAP3K101.92028690
24EEF2K1.89590721
25MST1R1.89060938
26CDK121.84838242
27SIK31.84263292
28NME11.78629391
29EPHB21.76378224
30MAP3K141.72549740
31TAF11.64307251
32ZAK1.42043054
33FGFR41.41206433
34VRK21.39192286
35MAP2K11.37150593
36MAP3K21.36522703
37MAP2K21.35894941
38TBK11.34822664
39TTN1.31095850
40IKBKE1.28875961
41NEK91.27535531
42RAF11.27020943
43JAK11.26770218
44GRK61.23784476
45MAP3K31.23394225
46MOS1.19352101
47FER1.13042155
48PIK3CG1.11643311
49MST41.08695646
50SIK11.08463100
51CCNB11.08132664
52RPS6KA51.08090650
53PRKCQ1.05132092
54TNK21.05098883
55PASK1.05096897
56KSR11.02947059
57MAP3K121.01526008
58LRRK20.99620502
59EIF2AK30.94993955
60MAP3K10.94122097
61STK100.93235735
62BRAF0.93227535
63MAP3K110.92794611
64IKBKB0.91071715
65BCKDK0.90999168
66TRIB30.89452113
67LYN0.88438810
68SIK20.87726726
69JAK30.86542086
70PRKCI0.85729342
71TAOK30.83233569
72NTRK30.82221272
73PIM10.81939565
74SYK0.79627927
75PAK40.79617412
76AURKA0.78533306
77PTK20.77810842
78EPHA40.75527519
79MAP3K80.75145941
80CSF1R0.75112171
81MARK30.74023141
82ITK0.72419493
83PTK60.71475013
84BMX0.70138560
85MAPKAPK50.69767181
86CDK90.67942162
87MAP3K70.67215249
88ALK0.66947916
89LATS20.66941368
90MELK0.65332144
91KIT0.64080174
92CHUK0.64011480
93IRAK30.61286296
94PAK10.60397705
95TAOK10.58609752
96PIM20.57618656
97RPS6KA40.54819008
98CDK40.52994053
99EPHB10.50925728
100MAPK70.50126914
101RPS6KA10.45883162
102FGFR30.45586042
103NEK10.44346549
104MINK10.43888115
105MATK0.43746130
106PRKCD0.42301155
107LCK0.40628440
108LATS10.40406609
109PRKD10.40103065
110ROCK20.39982003
111UHMK10.39563776
112CSK0.39113741
113MAPK120.38895428
114HIPK20.38286762
115HCK0.35646188
116PKN10.35604489
117DAPK20.35242744
118MAPKAPK20.34654795
119MAP2K30.33516359
120MARK20.32746835
121ILK0.32734640
122MAP2K40.30890470
123ICK0.30864272
124PDGFRA0.30769616
125DAPK30.30177167
126MAPK110.30154024
127AURKB0.29960114
128CDC42BPA0.29509773
129BMPR20.29338457
130MAP2K60.28827343
131PKN20.28623852
132BTK0.28572983
133CDK60.28043063
134JAK20.27000297
135TRPM70.26879538
136NEK20.26562087
137MAPK40.25710598
138PRKD20.25557804
139STK40.25038841
140FGR0.24937522
141STK240.24717272
142PRKCH0.24084853
143PDK10.24078330
144ADRBK20.22029439
145MET0.22027128
146CDK11A0.21067562
147FRK0.20831785
148STK110.19362102
149DDR20.18541173

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.74036077
2Allograft rejection_Homo sapiens_hsa053304.45166104
3Autoimmune thyroid disease_Homo sapiens_hsa053204.23232930
4Asthma_Homo sapiens_hsa053103.75392133
5Graft-versus-host disease_Homo sapiens_hsa053323.74161714
6Type I diabetes mellitus_Homo sapiens_hsa049403.33561046
7Ribosome_Homo sapiens_hsa030102.76845756
8Alcoholism_Homo sapiens_hsa050342.63674946
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.63474773
10Viral myocarditis_Homo sapiens_hsa054162.63157650
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.56439912
12* Basal cell carcinoma_Homo sapiens_hsa052172.54605506
13* Hedgehog signaling pathway_Homo sapiens_hsa043402.36274016
14Protein export_Homo sapiens_hsa030602.33714446
15B cell receptor signaling pathway_Homo sapiens_hsa046622.31614869
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.18828043
17Primary immunodeficiency_Homo sapiens_hsa053402.07048952
18Bladder cancer_Homo sapiens_hsa052191.87000536
19ECM-receptor interaction_Homo sapiens_hsa045121.85235939
20Herpes simplex infection_Homo sapiens_hsa051681.78688165
21* Proteoglycans in cancer_Homo sapiens_hsa052051.68661694
22Viral carcinogenesis_Homo sapiens_hsa052031.68653433
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67821331
24Influenza A_Homo sapiens_hsa051641.64523953
25* Melanogenesis_Homo sapiens_hsa049161.58918795
26Long-term potentiation_Homo sapiens_hsa047201.55268476
27VEGF signaling pathway_Homo sapiens_hsa043701.54981981
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51935722
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46102649
30p53 signaling pathway_Homo sapiens_hsa041151.46026287
31Epstein-Barr virus infection_Homo sapiens_hsa051691.44698409
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44360079
33Measles_Homo sapiens_hsa051621.40420828
34Amoebiasis_Homo sapiens_hsa051461.39406164
35Staphylococcus aureus infection_Homo sapiens_hsa051501.38750290
36Focal adhesion_Homo sapiens_hsa045101.33346149
37Glioma_Homo sapiens_hsa052141.32237947
38Small cell lung cancer_Homo sapiens_hsa052221.32187209
39* Hippo signaling pathway_Homo sapiens_hsa043901.31344694
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.28426356
41Antigen processing and presentation_Homo sapiens_hsa046121.24764952
42Acute myeloid leukemia_Homo sapiens_hsa052211.21698301
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20600464
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19220827
45Dorso-ventral axis formation_Homo sapiens_hsa043201.17499753
46* HTLV-I infection_Homo sapiens_hsa051661.16037982
47Toxoplasmosis_Homo sapiens_hsa051451.15853815
48MicroRNAs in cancer_Homo sapiens_hsa052061.10907954
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10859117
50GnRH signaling pathway_Homo sapiens_hsa049121.10492882
51* Wnt signaling pathway_Homo sapiens_hsa043101.09954198
52Axon guidance_Homo sapiens_hsa043601.08307819
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.08031188
54Vibrio cholerae infection_Homo sapiens_hsa051101.06245610
55Rheumatoid arthritis_Homo sapiens_hsa053231.05255164
56Apoptosis_Homo sapiens_hsa042101.04453284
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03578947
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02135534
59Non-small cell lung cancer_Homo sapiens_hsa052231.01903156
60T cell receptor signaling pathway_Homo sapiens_hsa046601.01307058
61Phenylalanine metabolism_Homo sapiens_hsa003601.00206083
62Melanoma_Homo sapiens_hsa052180.99607062
63Osteoclast differentiation_Homo sapiens_hsa043800.99290276
64Hematopoietic cell lineage_Homo sapiens_hsa046400.98201820
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96617278
66N-Glycan biosynthesis_Homo sapiens_hsa005100.94360536
67* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91970744
68* Pathways in cancer_Homo sapiens_hsa052000.90241307
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89347720
70MAPK signaling pathway_Homo sapiens_hsa040100.87065077
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.86141300
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.84754598
73Chronic myeloid leukemia_Homo sapiens_hsa052200.83335216
74Leishmaniasis_Homo sapiens_hsa051400.81743107
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81166502
76Adherens junction_Homo sapiens_hsa045200.81033767
77Estrogen signaling pathway_Homo sapiens_hsa049150.80968141
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80190396
79Rap1 signaling pathway_Homo sapiens_hsa040150.79694369
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78825701
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78693134
82DNA replication_Homo sapiens_hsa030300.78137087
83Renal cell carcinoma_Homo sapiens_hsa052110.77420889
84Base excision repair_Homo sapiens_hsa034100.75765471
85Pancreatic cancer_Homo sapiens_hsa052120.75758841
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75509980
87Gap junction_Homo sapiens_hsa045400.73407800
88Amphetamine addiction_Homo sapiens_hsa050310.73405346
89ErbB signaling pathway_Homo sapiens_hsa040120.73245986
90Tight junction_Homo sapiens_hsa045300.72709216
91Oxytocin signaling pathway_Homo sapiens_hsa049210.72506926
92Shigellosis_Homo sapiens_hsa051310.71864324
93Long-term depression_Homo sapiens_hsa047300.71640223
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71435918
95Thyroid cancer_Homo sapiens_hsa052160.71253049
96Salivary secretion_Homo sapiens_hsa049700.70994987
97TNF signaling pathway_Homo sapiens_hsa046680.70816804
98Hepatitis B_Homo sapiens_hsa051610.70182451
99Endometrial cancer_Homo sapiens_hsa052130.69833050
100Protein digestion and absorption_Homo sapiens_hsa049740.68828131
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68285894
102Dilated cardiomyopathy_Homo sapiens_hsa054140.68061281
103Thyroid hormone synthesis_Homo sapiens_hsa049180.67432666
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65310796
105Prolactin signaling pathway_Homo sapiens_hsa049170.64068936
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62731833
107Notch signaling pathway_Homo sapiens_hsa043300.62075724
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61708010
109Ras signaling pathway_Homo sapiens_hsa040140.61339581
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61334523
111Renin secretion_Homo sapiens_hsa049240.59332047
112Gastric acid secretion_Homo sapiens_hsa049710.58903089
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58191233
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57885255
115Fructose and mannose metabolism_Homo sapiens_hsa000510.57390230
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57291119
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57144515
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.56755321
119Salmonella infection_Homo sapiens_hsa051320.55802670
120Phagosome_Homo sapiens_hsa041450.55199708
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.54371230
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52413787
123Tuberculosis_Homo sapiens_hsa051520.51908843
124Hepatitis C_Homo sapiens_hsa051600.51724067
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.51633851
126Pentose phosphate pathway_Homo sapiens_hsa000300.47267478
127Chemokine signaling pathway_Homo sapiens_hsa040620.40330647
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37078150
129Mismatch repair_Homo sapiens_hsa034300.31297311
130Homologous recombination_Homo sapiens_hsa034400.28740305
131Biosynthesis of amino acids_Homo sapiens_hsa012300.18849121
132Colorectal cancer_Homo sapiens_hsa052100.17953709
133HIF-1 signaling pathway_Homo sapiens_hsa040660.17467952
134Non-homologous end-joining_Homo sapiens_hsa034500.15613858
135One carbon pool by folate_Homo sapiens_hsa006700.15055388
136Prostate cancer_Homo sapiens_hsa052150.14877945
137Spliceosome_Homo sapiens_hsa030400.14122632
138Nucleotide excision repair_Homo sapiens_hsa034200.13885051
139Sulfur relay system_Homo sapiens_hsa041220.13538903
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12328682
141Proteasome_Homo sapiens_hsa030500.08504547
142Inositol phosphate metabolism_Homo sapiens_hsa005620.08444878
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.07915544
144Pyrimidine metabolism_Homo sapiens_hsa002400.06554295
145RNA degradation_Homo sapiens_hsa030180.06410553
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.05890185
147Carbon metabolism_Homo sapiens_hsa012000.04689290
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02365874
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.01001721

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