WNT10B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.76830648
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.84511487
3glutamate secretion (GO:0014047)7.50783976
4synaptic vesicle maturation (GO:0016188)7.46114152
5cellular response to vitamin D (GO:0071305)7.33919434
6synaptic vesicle exocytosis (GO:0016079)6.78849582
7tooth mineralization (GO:0034505)6.32653725
8regulation of short-term neuronal synaptic plasticity (GO:0048172)6.29352637
9positive regulation of fibroblast migration (GO:0010763)5.82100291
10regulation of synaptic vesicle exocytosis (GO:2000300)5.74651290
11cellular response to vitamin (GO:0071295)5.39965853
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.39110397
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08247639
14positive regulation of odontogenesis (GO:0042482)5.01060380
15neurotransmitter secretion (GO:0007269)4.97336935
16regulation of synaptic vesicle transport (GO:1902803)4.90928359
17molting cycle (GO:0042303)4.77750475
18hair cycle (GO:0042633)4.77750475
19locomotory exploration behavior (GO:0035641)4.69637331
20regulation of neuronal synaptic plasticity (GO:0048168)4.69512336
21sodium ion export (GO:0071436)4.64045042
22positive regulation of synapse maturation (GO:0090129)4.59432831
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.57912734
24regulation of ARF protein signal transduction (GO:0032012)4.52387545
25protein heterotrimerization (GO:0070208)4.49725922
26endodermal cell differentiation (GO:0035987)4.48599824
27exploration behavior (GO:0035640)4.45810796
28cellular potassium ion homeostasis (GO:0030007)4.38162857
29superoxide anion generation (GO:0042554)4.21977195
30cell-substrate junction assembly (GO:0007044)4.19528805
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16487698
32establishment of skin barrier (GO:0061436)4.03971133
33ionotropic glutamate receptor signaling pathway (GO:0035235)4.03293774
34synaptic vesicle endocytosis (GO:0048488)4.03097405
35regulation of water loss via skin (GO:0033561)3.90476935
36regulation of synaptic plasticity (GO:0048167)3.90001568
37collagen fibril organization (GO:0030199)3.86102978
38neurotransmitter transport (GO:0006836)3.84558744
39regulation of odontogenesis (GO:0042481)3.83795064
40cerebellar granule cell differentiation (GO:0021707)3.82273219
41regulation of vesicle fusion (GO:0031338)3.77448768
42embryonic camera-type eye development (GO:0031076)3.77418858
43response to vitamin D (GO:0033280)3.76844503
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.72953987
45desmosome organization (GO:0002934)3.64161287
46negative regulation of dendrite morphogenesis (GO:0050774)3.57766917
47neuronal ion channel clustering (GO:0045161)3.57446345
48wound healing, spreading of epidermal cells (GO:0035313)3.55995444
49amino acid import (GO:0043090)3.55144635
50regulation of voltage-gated calcium channel activity (GO:1901385)3.52884246
51telomere maintenance via telomerase (GO:0007004)3.52130193
52positive regulation of membrane potential (GO:0045838)3.51882302
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51643301
54odontogenesis of dentin-containing tooth (GO:0042475)3.51544496
55regulation of extracellular matrix disassembly (GO:0010715)3.51480426
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.49310491
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47359878
58vitamin catabolic process (GO:0009111)3.46561526
59fat-soluble vitamin catabolic process (GO:0042363)3.46561526
60neuromuscular process controlling balance (GO:0050885)3.44096768
61synaptic transmission, glutamatergic (GO:0035249)3.43070268
62positive regulation of neurotransmitter transport (GO:0051590)3.42126852
63layer formation in cerebral cortex (GO:0021819)3.41788404
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38062727
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37442102
66protein localization to synapse (GO:0035418)3.37134744
67odontogenesis (GO:0042476)3.36876581
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36744576
69positive regulation of cell size (GO:0045793)3.36475877
70dendritic spine organization (GO:0097061)3.34729547
71regulation of neurotransmitter secretion (GO:0046928)3.34169268
72regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.32700208
73regulation of synapse structural plasticity (GO:0051823)3.32115553
74regulation of glutamate receptor signaling pathway (GO:1900449)3.32021154
75long-term memory (GO:0007616)3.30698258
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30566122
77regulation of neurotransmitter levels (GO:0001505)3.29787696
78positive regulation of neurotransmitter secretion (GO:0001956)3.28763336
79mating behavior (GO:0007617)3.27542664
80detection of temperature stimulus involved in sensory perception (GO:0050961)3.21086550
81detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.21086550
82cellular response to lithium ion (GO:0071285)3.20596291
83positive regulation of dendritic spine development (GO:0060999)3.19731802
84response to gravity (GO:0009629)3.19538692
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.17772388
86cerebellar Purkinje cell layer development (GO:0021680)3.16642946
87dendritic spine morphogenesis (GO:0060997)3.15733762
88collagen catabolic process (GO:0030574)3.15366037
89regulation of synapse maturation (GO:0090128)3.14580699
90positive regulation of extracellular matrix organization (GO:1903055)3.13651650
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.13312039
92positive regulation of osteoblast proliferation (GO:0033690)3.13294687
93positive regulation of vesicle fusion (GO:0031340)3.11773674
94lung-associated mesenchyme development (GO:0060484)3.10722402
95cell migration in hindbrain (GO:0021535)3.09776798
96establishment of synaptic vesicle localization (GO:0097480)3.09297555
97synaptic vesicle transport (GO:0048489)3.09297555
98prepulse inhibition (GO:0060134)3.07339461
99collagen metabolic process (GO:0032963)3.07205858
100inositol phosphate-mediated signaling (GO:0048016)3.04539398
101neuron-neuron synaptic transmission (GO:0007270)3.00860547
102biomineral tissue development (GO:0031214)3.00488885
103RNA-dependent DNA replication (GO:0006278)2.99452570
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.98926126
105cell adhesion mediated by integrin (GO:0033627)2.98536213
106positive regulation of protein dephosphorylation (GO:0035307)2.98372832
107estrogen biosynthetic process (GO:0006703)2.97912929
108cardiac right ventricle morphogenesis (GO:0003215)2.97331320
109homocysteine metabolic process (GO:0050667)2.97031417
110negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.96648331
111protein localization to microtubule (GO:0035372)2.96318651
112regulation of postsynaptic membrane potential (GO:0060078)2.94097313
113extracellular matrix disassembly (GO:0022617)2.94066878
114cerebral cortex neuron differentiation (GO:0021895)2.92570937
115antigen processing and presentation of endogenous antigen (GO:0019883)2.91259162
116viral transcription (GO:0019083)2.90280002
117negative regulation of keratinocyte proliferation (GO:0010839)2.89623999
118NIK/NF-kappaB signaling (GO:0038061)2.89282072
119glycine transport (GO:0015816)2.88635777
120regulation of dendritic spine morphogenesis (GO:0061001)2.87388982
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87023508
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85407785
123multicellular organismal macromolecule metabolic process (GO:0044259)2.83707212
124skin morphogenesis (GO:0043589)2.83513250
125signal complex assembly (GO:0007172)2.83378726
126postsynaptic membrane organization (GO:0001941)2.82523976
127regulation of neurotransmitter transport (GO:0051588)2.82299886
128inner ear receptor cell development (GO:0060119)2.80720422
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80604946
130regulation of synaptic transmission (GO:0050804)2.80503219
131mitochondrion transport along microtubule (GO:0047497)2.80475962
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.80475962
133multicellular organismal catabolic process (GO:0044243)2.80065803
134negative regulation of microtubule polymerization (GO:0031115)2.79390806
135vocalization behavior (GO:0071625)2.77854775
136reflex (GO:0060004)2.77540824
137dicarboxylic acid transport (GO:0006835)2.77171828
138negative regulation of fatty acid transport (GO:2000192)2.75952254
139activation of protein kinase A activity (GO:0034199)2.75462621
140regulation of mitotic spindle organization (GO:0060236)2.72602274
141multicellular organismal metabolic process (GO:0044236)2.72479566
142heterochromatin organization (GO:0070828)2.72119914
143glutamate receptor signaling pathway (GO:0007215)2.71471364
144activation of Rac GTPase activity (GO:0032863)2.70353316
145cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66052981
146regulation of RIG-I signaling pathway (GO:0039535)2.65779799
147establishment of mitochondrion localization (GO:0051654)2.65028356
148neuron cell-cell adhesion (GO:0007158)2.64759775
149intermediate filament organization (GO:0045109)2.63870425
150L-amino acid import (GO:0043092)2.63795402
151cerebellar Purkinje cell differentiation (GO:0021702)2.63714508
152negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62662270
153response to muramyl dipeptide (GO:0032495)2.62599070
154lateral sprouting from an epithelium (GO:0060601)2.61619551
155long-term synaptic potentiation (GO:0060291)2.60981635
156phosphorelay signal transduction system (GO:0000160)2.60672021
157translational termination (GO:0006415)2.59776627
158neuromuscular process (GO:0050905)2.59109926
159ribosomal small subunit biogenesis (GO:0042274)2.58778147
160potassium ion homeostasis (GO:0055075)2.58386027
161prostanoid biosynthetic process (GO:0046457)2.57733508
162prostaglandin biosynthetic process (GO:0001516)2.57733508
163regulation of extracellular matrix organization (GO:1903053)2.56873343
164peptidyl-arginine omega-N-methylation (GO:0035247)2.56803799
165regulation of protein dephosphorylation (GO:0035304)2.55137635
166wound healing, spreading of cells (GO:0044319)2.54004635
167embryonic skeletal joint morphogenesis (GO:0060272)2.53530450
168response to lipoprotein particle (GO:0055094)2.52927681
169midbrain development (GO:0030901)2.52682527
170visual behavior (GO:0007632)2.50517316
171androgen biosynthetic process (GO:0006702)2.49818675
172chondrocyte development (GO:0002063)2.49358149
173regulation of exocytosis (GO:0017157)2.48732701
174cellular response to nutrient (GO:0031670)2.48415135
175branching involved in labyrinthine layer morphogenesis (GO:0060670)2.47874629
176regulation of osteoblast proliferation (GO:0033688)2.47744495
177positive regulation of gamma-delta T cell activation (GO:0046645)2.45575753
178chondrocyte proliferation (GO:0035988)2.44701618
179white fat cell differentiation (GO:0050872)2.43647499
180positive regulation of epidermal cell differentiation (GO:0045606)2.43642671
181cytoskeletal anchoring at plasma membrane (GO:0007016)2.40651532
182thymic T cell selection (GO:0045061)2.39691266
183positive regulation of granulocyte chemotaxis (GO:0071624)2.37766722
184regulation of spindle organization (GO:0090224)2.36571754
185planar cell polarity pathway involved in neural tube closure (GO:0090179)2.32877656
186vitamin transmembrane transport (GO:0035461)2.32717697
187positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30233702
188DNA integration (GO:0015074)2.29665708
189mesodermal cell differentiation (GO:0048333)2.28416767
190centriole assembly (GO:0098534)2.28025314
191interferon-gamma secretion (GO:0072643)2.27885743
192osteoblast differentiation (GO:0001649)2.27418979
193epidermis development (GO:0008544)2.25077438
194positive regulation of cholesterol efflux (GO:0010875)2.24032536
195epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22309911
196cellular response to gamma radiation (GO:0071480)2.21620611
197positive regulation of endothelial cell apoptotic process (GO:2000353)2.21193333
198multicellular organismal water homeostasis (GO:0050891)2.21005984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.80968134
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.57335500
3E2F7_22180533_ChIP-Seq_HELA_Human3.57141404
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.16900362
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.00888924
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.85992868
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.73699554
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.61128354
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.57307724
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45292089
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.40599661
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38735088
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.33329287
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31917804
15EZH2_22144423_ChIP-Seq_EOC_Human2.31370770
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30883125
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.29529581
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.27774012
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21689589
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21037822
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16751836
22MYC_22102868_ChIP-Seq_BL_Human2.14272712
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.06778003
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.06778003
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03581004
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.00681257
27REST_21632747_ChIP-Seq_MESCs_Mouse2.00381691
28* TP63_17297297_ChIP-ChIP_HaCaT_Human10.9293385
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98480959
30AR_21909140_ChIP-Seq_LNCAP_Human1.98454441
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.97278005
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.96748243
33* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94543665
34* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94543665
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93488395
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.91462960
37P63_26484246_Chip-Seq_KERATINOCYTES_Human1.90634792
38DROSHA_22980978_ChIP-Seq_HELA_Human1.87958415
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87414474
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86731711
41* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86693379
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86210239
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84767032
44* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.84658687
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83734286
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.82013209
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.78282399
48SMC4_20622854_ChIP-Seq_HELA_Human1.77565093
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77167381
50P68_20966046_ChIP-Seq_HELA_Human1.74096195
51* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72664028
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71989402
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70759745
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69771427
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.69704040
56* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69673901
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66924492
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66399182
59ATF3_27146783_Chip-Seq_COLON_Human1.65082988
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64717193
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61418182
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61037085
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60871792
64* TET1_21451524_ChIP-Seq_MESCs_Mouse1.60434411
65* ESR1_21235772_ChIP-Seq_MCF-7_Human1.59962371
66* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59124607
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59075911
68* CTCF_27219007_Chip-Seq_Bcells_Human1.54912923
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54424168
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51012786
71* RACK7_27058665_Chip-Seq_MCF-7_Human1.50442052
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50092388
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49438632
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48260296
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47303806
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46279114
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45958470
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45479342
79XRN2_22483619_ChIP-Seq_HELA_Human1.43735046
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.43699518
81* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42683060
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42163188
83CREB1_26743006_Chip-Seq_LNCaP_Human1.42119247
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41466483
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36423547
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.35791880
87LXR_22292898_ChIP-Seq_THP-1_Human1.31951056
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30415036
89* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26852149
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26772940
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.26726804
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26232389
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.25736080
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.24000372
95VDR_21846776_ChIP-Seq_THP-1_Human1.23058899
96* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22432663
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22248579
98* SA1_27219007_Chip-Seq_ERYTHROID_Human1.21596524
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21577479
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21448694
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20381125
102* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19042820
103* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18646074
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18451830
105MAF_26560356_Chip-Seq_TH1_Human1.18387884
106KLF5_25053715_ChIP-Seq_YYC3_Human1.17719019
107ZNF263_19887448_ChIP-Seq_K562_Human1.17611051
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17249825
109* KDM2B_26808549_Chip-Seq_DND41_Human1.16683821
110UTX_26944678_Chip-Seq_JUKART_Human1.15564139
111* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15053128
112* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14227773
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14086228
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11715191
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11531578
116MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11494875
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10563350
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10505241
119OCT4_19829295_ChIP-Seq_ESCs_Human1.10117743
120PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09359947
121NOTCH1_21737748_ChIP-Seq_TLL_Human1.08618021
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08077668
123CLOCK_20551151_ChIP-Seq_293T_Human1.08061547
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07890698
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.07297774
126* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06919314
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06605015
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05992871
129MYB_26560356_Chip-Seq_TH2_Human1.05074365
130ELF1_20517297_ChIP-Seq_JURKAT_Human1.04260731
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04255613
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03494671
133TP63_22573176_ChIP-Seq_HFKS_Human1.03452543
134TCF7_22412390_ChIP-Seq_EML_Mouse1.03029018
135* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02893229
136GATA1_26923725_Chip-Seq_HPCs_Mouse1.02811757
137MAF_26560356_Chip-Seq_TH2_Human1.02721518
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02216916
139CJUN_26792858_Chip-Seq_BT549_Human1.01008975
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99230347
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98483298
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98468434
143MYB_26560356_Chip-Seq_TH1_Human0.97406082
144* TP53_20018659_ChIP-ChIP_R1E_Mouse0.96941632
145GATA6_25053715_ChIP-Seq_YYC3_Human0.96875916
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95733449
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95443338
148KDM2B_26808549_Chip-Seq_K562_Human0.94431941
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94223027
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.93737321
151TP53_22127205_ChIP-Seq_IMR90_Human0.92742915
152CTCF_21964334_Chip-Seq_Bcells_Human0.91587685
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.89986182
154VDR_24763502_ChIP-Seq_THP-1_Human0.89801159
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88929839
156PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88270095
157* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87586150
158BRD4_25478319_ChIP-Seq_HGPS_Human0.85470284
159ELK1_22589737_ChIP-Seq_MCF10A_Human0.85242172
160NCOR1_26117541_ChIP-Seq_K562_Human0.79587848
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78623615
162ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.78454508
163SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78000402
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76021668
165AHR_22903824_ChIP-Seq_MCF-7_Human0.75564663
166KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75563813
167* GATA3_24758297_ChIP-Seq_MCF-7_Human0.74999873
168FLI1_27457419_Chip-Seq_LIVER_Mouse0.74411818
169TBX20_22080862_ChIP-Seq_HEART_Mouse0.74365277
170TBX20_22328084_ChIP-Seq_HEART_Mouse0.74365277
171FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.73939639
172GF1_26923725_Chip-Seq_HPCs_Mouse0.73929475
173GATA4_25053715_ChIP-Seq_YYC3_Human0.71687357
174IRF8_27001747_Chip-Seq_BMDM_Mouse0.71432237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.84071227
2MP0003880_abnormal_central_pattern4.58765434
3MP0005275_abnormal_skin_tensile4.19334956
4MP0000566_synostosis3.80664149
5MP0005423_abnormal_somatic_nervous3.77795798
6MP0003635_abnormal_synaptic_transmissio3.70041638
7MP0002254_reproductive_system_inflammat3.69612278
8MP0000579_abnormal_nail_morphology3.57220793
9MP0008438_abnormal_cutaneous_collagen3.42387691
10MP0004270_analgesia3.36215989
11MP0000383_abnormal_hair_follicle3.19880093
12MP0002064_seizures3.14872218
13MP0002102_abnormal_ear_morphology3.01930127
14MP0002063_abnormal_learning/memory/cond2.95591395
15MP0003705_abnormal_hypodermis_morpholog2.88408787
16MP0003941_abnormal_skin_development2.79853936
17MP0009745_abnormal_behavioral_response2.65927900
18MP0010678_abnormal_skin_adnexa2.54502029
19MP0002060_abnormal_skin_morphology2.51116490
20MP0001486_abnormal_startle_reflex2.29056910
21MP0002822_catalepsy2.27761932
22MP0002572_abnormal_emotion/affect_behav2.25248736
23MP0001968_abnormal_touch/_nociception2.20946336
24MP0000762_abnormal_tongue_morphology2.19868563
25MP0009384_cardiac_valve_regurgitation2.18050558
26MP0002272_abnormal_nervous_system2.14247581
27MP0003566_abnormal_cell_adhesion2.14145952
28MP0001346_abnormal_lacrimal_gland2.09317708
29MP0005503_abnormal_tendon_morphology2.09105722
30MP0002734_abnormal_mechanical_nocicepti2.07828790
31MP0002234_abnormal_pharynx_morphology2.05933366
32MP0002896_abnormal_bone_mineralization2.01547474
33MP0001542_abnormal_bone_strength2.01108920
34MP0003879_abnormal_hair_cell1.98411208
35MP0005623_abnormal_meninges_morphology1.97081438
36MP0003195_calcinosis1.91221225
37MP0003329_amyloid_beta_deposits1.89880750
38MP0000537_abnormal_urethra_morphology1.83982060
39MP0001188_hyperpigmentation1.76421669
40MP0010234_abnormal_vibrissa_follicle1.75559987
41MP0009046_muscle_twitch1.75190497
42MP0004811_abnormal_neuron_physiology1.73155716
43MP0003938_abnormal_ear_development1.72110294
44MP0002735_abnormal_chemical_nociception1.71479355
45MP0002736_abnormal_nociception_after1.69777832
46MP0004484_altered_response_of1.69317195
47MP0005451_abnormal_body_composition1.67497583
48MP0008057_abnormal_DNA_replication1.65084453
49MP0002249_abnormal_larynx_morphology1.63785075
50MP0001216_abnormal_epidermal_layer1.63008592
51MP0002098_abnormal_vibrissa_morphology1.62581807
52MP0001501_abnormal_sleep_pattern1.60229583
53MP0003123_paternal_imprinting1.56719027
54MP0008569_lethality_at_weaning1.55864954
55MP0003453_abnormal_keratinocyte_physiol1.51273735
56MP0001243_abnormal_dermal_layer1.51113478
57MP0000778_abnormal_nervous_system1.50517268
58MP0000955_abnormal_spinal_cord1.50123762
59MP0001348_abnormal_lacrimal_gland1.50087251
60MP0001905_abnormal_dopamine_level1.49347666
61MP0005257_abnormal_intraocular_pressure1.46461090
62MP0002108_abnormal_muscle_morphology1.45836694
63MP0010030_abnormal_orbit_morphology1.43158434
64MP0005076_abnormal_cell_differentiation1.41918464
65MP0010771_integument_phenotype1.41529308
66MP0005508_abnormal_skeleton_morphology1.40613424
67MP0003111_abnormal_nucleus_morphology1.36293354
68MP0002796_impaired_skin_barrier1.35677291
69MP0000685_abnormal_immune_system1.34810691
70MP0000427_abnormal_hair_cycle1.34541098
71MP0002066_abnormal_motor_capabilities/c1.30692486
72MP0000377_abnormal_hair_follicle1.30128264
73MP0009379_abnormal_foot_pigmentation1.29975872
74MP0002933_joint_inflammation1.29151494
75MP0003283_abnormal_digestive_organ1.27173760
76MP0002067_abnormal_sensory_capabilities1.26813868
77MP0002396_abnormal_hematopoietic_system1.26655651
78MP0002882_abnormal_neuron_morphology1.26096482
79MP0001970_abnormal_pain_threshold1.25902489
80MP0002733_abnormal_thermal_nociception1.24252545
81MP0000462_abnormal_digestive_system1.23318631
82MP0001873_stomach_inflammation1.23008287
83MP0005501_abnormal_skin_physiology1.22877732
84MP0001958_emphysema1.22803581
85MP0000163_abnormal_cartilage_morphology1.22060367
86MP0002152_abnormal_brain_morphology1.22048338
87MP0010352_gastrointestinal_tract_polyps1.21719234
88MP0000613_abnormal_salivary_gland1.20667193
89MP0000647_abnormal_sebaceous_gland1.20560664
90MP0000467_abnormal_esophagus_morphology1.17459901
91MP0005387_immune_system_phenotype1.16455183
92MP0001790_abnormal_immune_system1.16455183
93MP0001440_abnormal_grooming_behavior1.15954498
94MP0003693_abnormal_embryo_hatching1.14298156
95MP0005390_skeleton_phenotype1.13626618
96MP0004742_abnormal_vestibular_system1.13249312
97MP0000432_abnormal_head_morphology1.12315430
98MP0001986_abnormal_taste_sensitivity1.11101071
99MP0002557_abnormal_social/conspecific_i1.10903282
100MP0004233_abnormal_muscle_weight1.10342698
101MP0002115_abnormal_skeleton_extremities1.09217607
102MP0002282_abnormal_trachea_morphology1.08190795
103MP0009053_abnormal_anal_canal1.07967280
104MP0004947_skin_inflammation1.07108397
105MP0005023_abnormal_wound_healing1.06683208
106MP0004185_abnormal_adipocyte_glucose1.05951405
107MP0003091_abnormal_cell_migration1.04493281
108MP0002877_abnormal_melanocyte_morpholog1.04486268
109MP0003690_abnormal_glial_cell1.03666863
110MP0003861_abnormal_nervous_system1.03209322
111MP0003755_abnormal_palate_morphology1.01931943
112MP0004272_abnormal_basement_membrane1.01568504
113MP0009250_abnormal_appendicular_skeleto1.00191532
114MP0002113_abnormal_skeleton_development0.99405569
115MP0003045_fibrosis0.99198813
116MP0001299_abnormal_eye_distance/0.98675520
117MP0003279_aneurysm0.98126035
118MP0002111_abnormal_tail_morphology0.97149252
119MP0003935_abnormal_craniofacial_develop0.96453813
120MP0001533_abnormal_skeleton_physiology0.96382396
121MP0003634_abnormal_glial_cell0.96279340
122MP0002184_abnormal_innervation0.95491535
123MP0004858_abnormal_nervous_system0.94295072
124* MP0000733_abnormal_muscle_development0.94066201
125MP0001502_abnormal_circadian_rhythm0.93265603
126MP0008874_decreased_physiological_sensi0.93225606
127MP0002168_other_aberrant_phenotype0.91460919
128MP0000490_abnormal_crypts_of0.91365242
129MP0000631_abnormal_neuroendocrine_gland0.90143890
130MP0004924_abnormal_behavior0.89896120
131MP0005386_behavior/neurological_phenoty0.89896120
132MP0003300_gastrointestinal_ulcer0.89149969
133MP0004510_myositis0.85994392
134MP0001177_atelectasis0.85674496
135MP0009672_abnormal_birth_weight0.84637016
136MP0002109_abnormal_limb_morphology0.84163756
137MP0005646_abnormal_pituitary_gland0.81400949
138MP0001849_ear_inflammation0.81364539
139MP0000470_abnormal_stomach_morphology0.80925494
140MP0003795_abnormal_bone_structure0.80105915
141MP0003436_decreased_susceptibility_to0.80002052
142MP0003937_abnormal_limbs/digits/tail_de0.79594954
143MP0003631_nervous_system_phenotype0.78321103
144MP0008260_abnormal_autophagy0.77541729
145MP0001800_abnormal_humoral_immune0.76714982
146MP0003315_abnormal_perineum_morphology0.76055040
147MP0000678_abnormal_parathyroid_gland0.76016935
148MP0006035_abnormal_mitochondrial_morpho0.75999881
149MP0002998_abnormal_bone_remodeling0.75669927
150MP0009333_abnormal_splenocyte_physiolog0.75445501
151MP0000367_abnormal_coat/_hair0.74698590
152MP0003448_altered_tumor_morphology0.73841011
153MP0003787_abnormal_imprinting0.73272357
154MP0003075_altered_response_to0.73185450
155MP0004782_abnormal_surfactant_physiolog0.71202762
156MP0003183_abnormal_peptide_metabolism0.69575432
157MP0010094_abnormal_chromosome_stability0.69058394
158MP0001963_abnormal_hearing_physiology0.68052279
159MP0003633_abnormal_nervous_system0.67964250
160MP0000428_abnormal_craniofacial_morphol0.66890624
161MP0002873_normal_phenotype0.66002242
162MP0002089_abnormal_postnatal_growth/wei0.65942470
163MP0002169_no_abnormal_phenotype0.65646841
164MP0000920_abnormal_myelination0.63780486
165MP0001943_abnormal_respiration0.63387085
166MP0001191_abnormal_skin_condition0.63173267
167MP0004381_abnormal_hair_follicle0.63160252
168MP0000026_abnormal_inner_ear0.62165694
169MP0000350_abnormal_cell_proliferation0.60917313
170MP0003632_abnormal_nervous_system0.60305129
171MP0008961_abnormal_basal_metabolism0.60260391
172MP0006276_abnormal_autonomic_nervous0.59834243
173MP0001529_abnormal_vocalization0.59597012
174MP0010769_abnormal_survival0.59385377
175MP0010768_mortality/aging0.57850189
176MP0003077_abnormal_cell_cycle0.57753858
177MP0002229_neurodegeneration0.56531127
178MP0003956_abnormal_body_size0.56020196
179MP0010770_preweaning_lethality0.54455937
180MP0002082_postnatal_lethality0.54455937
181MP0003763_abnormal_thymus_physiology0.53747701
182MP0003122_maternal_imprinting0.53710196
183MP0003942_abnormal_urinary_system0.53331921
184MP0002081_perinatal_lethality0.52932251
185MP0001731_abnormal_postnatal_growth0.51245557

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.89269208
2Milia (HP:0001056)6.39395449
3Focal motor seizures (HP:0011153)6.23094106
4Supranuclear gaze palsy (HP:0000605)5.73980802
5Amelogenesis imperfecta (HP:0000705)5.73931025
6Atrophic scars (HP:0001075)5.70502636
7Onycholysis (HP:0001806)5.07435225
8Premature rupture of membranes (HP:0001788)5.02142710
9Ankle clonus (HP:0011448)4.39424557
10Focal seizures (HP:0007359)4.08087826
11Annular pancreas (HP:0001734)3.99885789
12Epileptic encephalopathy (HP:0200134)3.93301294
13Fragile nails (HP:0001808)3.81624029
14Action tremor (HP:0002345)3.75425927
15Neurofibrillary tangles (HP:0002185)3.73631442
16Fragile skin (HP:0001030)3.57921963
17Cerebral inclusion bodies (HP:0100314)3.55253085
18Abnormality of binocular vision (HP:0011514)3.47562316
19Diplopia (HP:0000651)3.47562316
20Protrusio acetabuli (HP:0003179)3.46163598
21Ankle contracture (HP:0006466)3.44290674
22Obstructive sleep apnea (HP:0002870)3.44087919
23Neuronal loss in central nervous system (HP:0002529)3.40036236
24Plantar hyperkeratosis (HP:0007556)3.34611422
25Small epiphyses (HP:0010585)3.34020412
26Postural instability (HP:0002172)3.30379042
27Epiphyseal dysplasia (HP:0002656)3.28511273
28Fatigable weakness (HP:0003473)3.26263636
29Abnormality of the neuromuscular junction (HP:0003398)3.26263636
30Visual hallucinations (HP:0002367)3.16823891
31Truncal ataxia (HP:0002078)3.14728027
32Spastic gait (HP:0002064)3.14407423
33Mesomelia (HP:0003027)3.14084033
34Papilledema (HP:0001085)3.11771988
35Neonatal short-limb short stature (HP:0008921)3.08965904
36Dysmetria (HP:0001310)3.06662709
37Limb dystonia (HP:0002451)3.01907896
38Febrile seizures (HP:0002373)2.96319937
39Bradykinesia (HP:0002067)2.95362329
40Depression (HP:0000716)2.94513879
41Severe visual impairment (HP:0001141)2.94006829
42Natal tooth (HP:0000695)2.92338043
43Atonic seizures (HP:0010819)2.91332533
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.90626959
45Slow saccadic eye movements (HP:0000514)2.90113025
46Thick nail (HP:0001805)2.89610474
47Urinary urgency (HP:0000012)2.88378788
48Follicular hyperkeratosis (HP:0007502)2.87234763
49Tetraplegia (HP:0002445)2.81547679
50Generalized tonic-clonic seizures (HP:0002069)2.80163316
51Broad distal phalanx of finger (HP:0009836)2.79233227
52Akinesia (HP:0002304)2.77659174
53Urinary bladder sphincter dysfunction (HP:0002839)2.69183978
54Irregular epiphyses (HP:0010582)2.63559784
55Alopecia of scalp (HP:0002293)2.62873660
56Impaired vibration sensation in the lower limbs (HP:0002166)2.60640176
57Pendular nystagmus (HP:0012043)2.59980277
58Shallow orbits (HP:0000586)2.57526440
59Increased connective tissue (HP:0009025)2.56199535
60Concave nail (HP:0001598)2.54436849
61Dysmetric saccades (HP:0000641)2.53392073
62Clonus (HP:0002169)2.51151037
63Delusions (HP:0000746)2.50306723
64Nail dystrophy (HP:0008404)2.44660776
65Impaired smooth pursuit (HP:0007772)2.41938986
66Poor eye contact (HP:0000817)2.41430000
67Insomnia (HP:0100785)2.38917931
68Abnormality of saccadic eye movements (HP:0000570)2.38059115
69Turricephaly (HP:0000262)2.37326416
70Aplasia involving bones of the extremities (HP:0009825)2.37137647
71Aplasia involving bones of the upper limbs (HP:0009823)2.37137647
72Aplasia of the phalanges of the hand (HP:0009802)2.37137647
73Rigidity (HP:0002063)2.36621468
74Abnormal tarsal ossification (HP:0008369)2.33567712
75Status epilepticus (HP:0002133)2.33297195
76Amblyopia (HP:0000646)2.32151855
77Torticollis (HP:0000473)2.31502543
78Severe Myopia (HP:0011003)2.30789623
79Intention tremor (HP:0002080)2.30270312
80Abnormal ossification of hand bones (HP:0005921)2.29781012
81Striae distensae (HP:0001065)2.28634302
82Cupped ribs (HP:0000887)2.28591316
83Spinal canal stenosis (HP:0003416)2.26510083
84Hypercortisolism (HP:0001578)2.24790058
85Type 1 muscle fiber predominance (HP:0003803)2.24686093
86Ulnar bowing (HP:0003031)2.23139376
87Pili torti (HP:0003777)2.22667875
88Soft skin (HP:0000977)2.20963788
89Peritonitis (HP:0002586)2.20310873
90Metaphyseal irregularity (HP:0003025)2.20025660
91Dysdiadochokinesis (HP:0002075)2.19479713
92Hypoplasia of dental enamel (HP:0006297)2.19137290
93Dilatation of the ascending aorta (HP:0005111)2.18587681
94Distal lower limb amyotrophy (HP:0008944)2.18436117
95Abnormal social behavior (HP:0012433)2.17438610
96Impaired social interactions (HP:0000735)2.17438610
97Absence seizures (HP:0002121)2.17054393
98Thickened helices (HP:0000391)2.15684533
99Osteolytic defects of the hand bones (HP:0009699)2.15371719
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.15371719
101Pointed chin (HP:0000307)2.15071699
102Sleep apnea (HP:0010535)2.14305963
103Metaphyseal cupping (HP:0003021)2.13537294
104Cerebral hypomyelination (HP:0006808)2.13360415
105Abnormality of the corticospinal tract (HP:0002492)2.12732901
106Ridged nail (HP:0001807)2.11952979
107Stereotypic behavior (HP:0000733)2.08952027
108Mutism (HP:0002300)2.08330287
109Dialeptic seizures (HP:0011146)2.06109522
110Palmoplantar hyperkeratosis (HP:0000972)2.05764502
111Abnormality of the parietal bone (HP:0002696)2.04102090
112Mild short stature (HP:0003502)2.02114201
113Abnormal eating behavior (HP:0100738)2.01039199
114Lower limb asymmetry (HP:0100559)2.00807726
115Palmar hyperkeratosis (HP:0010765)2.00639513
116Truncus arteriosus (HP:0001660)2.00181664
117Cervical subluxation (HP:0003308)1.99791862
118Degeneration of the lateral corticospinal tracts (HP:0002314)1.97881425
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97881425
120Focal dystonia (HP:0004373)1.97794001
121Aortic dissection (HP:0002647)1.97614632
122Abnormality of the lower motor neuron (HP:0002366)1.97115663
123Ankyloglossia (HP:0010296)1.96164108
124Delayed epiphyseal ossification (HP:0002663)1.94580449
125Spinal rigidity (HP:0003306)1.94549712
126Resting tremor (HP:0002322)1.94166470
127Advanced eruption of teeth (HP:0006288)1.94143140
128Breech presentation (HP:0001623)1.93951460
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93855187
130Wormian bones (HP:0002645)1.93614282
131Abnormality of the columella (HP:0009929)1.93304469
132Genu recurvatum (HP:0002816)1.93240234
133Morphological abnormality of the pyramidal tract (HP:0002062)1.92874291
134Abnormal hand bone ossification (HP:0010660)1.92023961
135Elfin facies (HP:0004428)1.91862267
136Increased IgE level (HP:0003212)1.91851656
137Hypokinesia (HP:0002375)1.91815124
138Stenosis of the external auditory canal (HP:0000402)1.91805357
139Tibial bowing (HP:0002982)1.90802125
140Unsteady gait (HP:0002317)1.90794669
141Epileptiform EEG discharges (HP:0011182)1.90741447
142Short 4th metacarpal (HP:0010044)1.90643187
143Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90643187
144Bladder diverticulum (HP:0000015)1.89694614
145Type 2 muscle fiber atrophy (HP:0003554)1.89306567
146Bowel incontinence (HP:0002607)1.89263400
147Unilateral renal agenesis (HP:0000122)1.89042106
148Impulsivity (HP:0100710)1.88824883
149Limited elbow extension (HP:0001377)1.88340472
150Abnormal foot bone ossification (HP:0010675)1.87919620
151Woolly hair (HP:0002224)1.87075392
152Difficulty climbing stairs (HP:0003551)1.86607744
153Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86016611
154Apathy (HP:0000741)1.85474799
155Coxa vara (HP:0002812)1.85052009
156Flattened epiphyses (HP:0003071)1.84901047
157Osteoarthritis (HP:0002758)1.82082150
158Glossoptosis (HP:0000162)1.80933823
159Rapidly progressive (HP:0003678)1.80556806
160Mitral valve prolapse (HP:0001634)1.80356125
161Abnormal large intestine physiology (HP:0012700)1.77991597
162Neurodegeneration (HP:0002180)1.77956895
163Choreoathetosis (HP:0001266)1.77601900
164* Incomplete penetrance (HP:0003829)1.76771011
165Elbow flexion contracture (HP:0002987)1.76156379
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.76113826
167Muscle fiber atrophy (HP:0100295)1.75932669
168Pterygium (HP:0001059)1.75916651
169Entropion (HP:0000621)1.75848570
170Impaired vibratory sensation (HP:0002495)1.75605630
171Hypoplastic ischia (HP:0003175)1.75080814
172Absent epiphyses (HP:0010577)1.74926346
173Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74926346
174Progressive cerebellar ataxia (HP:0002073)1.74015687
175Stillbirth (HP:0003826)1.73707650
176Craniofacial dystonia (HP:0012179)1.73336507
177Slender build (HP:0001533)1.72649830
178Thoracolumbar scoliosis (HP:0002944)1.72574228
179Abnormality of carpal bone ossification (HP:0006257)1.72472638
180Lower limb muscle weakness (HP:0007340)1.71559738
181Abnormality of ocular smooth pursuit (HP:0000617)1.71120414
182Mildly elevated creatine phosphokinase (HP:0008180)1.71115515
183Muscle fiber splitting (HP:0003555)1.70138694
184Abnormal number of incisors (HP:0011064)1.68115904
185Persistence of primary teeth (HP:0006335)1.67662353
186Abnormality of macular pigmentation (HP:0008002)1.67458001
187Distal lower limb muscle weakness (HP:0009053)1.66963536
188Cheilitis (HP:0100825)1.66831933
189Abnormal blistering of the skin (HP:0008066)1.66245102
190Abnormality of the proximal phalanges of the hand (HP:0009834)1.66199315
191Ectopia lentis (HP:0001083)1.66106649
192Partial duplication of thumb phalanx (HP:0009944)1.65883217
193Blue sclerae (HP:0000592)1.65743408
194Aggressive behavior (HP:0000718)1.65575856
195Termporal pattern (HP:0011008)1.65460315
196Abnormal delivery (HP:0001787)1.64431967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.38812781
2EPHA24.14337564
3BUB13.21687304
4PAK63.20608282
5PIK3CG2.93618952
6NTRK32.90799002
7TRIB32.87210363
8DDR22.67784183
9MAP4K12.62712936
10UHMK12.51839863
11MAP3K142.51524311
12TTN2.39737166
13RIPK42.24188389
14KSR22.23827509
15SMG12.19495999
16CAMKK12.18746929
17MAP3K102.12873210
18MAP3K92.12532792
19EEF2K1.97308347
20EIF2AK21.91598482
21TSSK61.88989712
22MINK11.83839609
23RPS6KA41.80359388
24MARK11.77015155
25MAPK71.74920926
26NEK21.73252078
27ARAF1.72257897
28BLK1.69014993
29BMX1.67491291
30PINK11.62687180
31MAP3K31.61334242
32NTRK21.60408026
33BRSK11.54119812
34SIK21.53571130
35CDK191.51845741
36ALK1.51197429
37STK31.48165003
38PKN21.47568228
39LATS11.46799031
40SIK11.42452467
41RPS6KL11.41143942
42RPS6KC11.41143942
43RPS6KA61.38429997
44TAOK31.37382650
45MAP3K131.36281695
46MTOR1.34197926
47MARK21.33509908
48DAPK11.29233170
49JAK11.26642750
50NTRK11.26602256
51FGFR41.26132992
52NME11.23385419
53EPHB21.23169265
54STK381.22449158
55MAP3K71.20986103
56TYRO31.19621588
57CDK41.15994111
58DYRK31.15878451
59MKNK21.14994771
60TAOK21.14814923
61GRK51.14309757
62MAP3K111.12840486
63IKBKB1.11945250
64NEK61.09987552
65NME21.09905622
66RIPK11.09051385
67LRRK21.08061362
68MAPK121.07995969
69RAF11.07447011
70PRPF4B1.07343613
71PTK61.07208237
72CDK51.06623833
73PIM21.04364119
74IRAK31.02725182
75STK241.02069661
76TNK21.00917151
77BRAF0.99497899
78KSR10.97243078
79CDK150.95967234
80CDK11A0.95050901
81IRAK20.94892419
82CDK60.93868253
83TRPM70.92981350
84STK100.92477936
85MST40.91313824
86CDK180.88773525
87JAK30.87827727
88CHUK0.87634630
89ERN10.87046871
90CCNB10.86481064
91TBK10.86267346
92PAK20.84766456
93STK38L0.84655814
94CDK140.83555970
95MAP3K10.83120325
96PRKCH0.82237918
97AURKB0.82078019
98MAP3K80.81545172
99CDK120.78686649
100STK110.78446418
101MAP2K40.77865384
102WEE10.76826180
103PLK20.76439954
104EPHB10.74351106
105CAMK2B0.74214084
106MAP3K120.72652352
107PDK10.72598288
108PDPK10.72291797
109FGFR20.71902516
110CSF1R0.71123607
111PNCK0.70837966
112CLK10.70310127
113ICK0.68669310
114MKNK10.68260649
115EPHA30.67693130
116MAPKAPK50.67611012
117MAPK130.67004420
118FER0.66863808
119CAMKK20.66704417
120LATS20.65976329
121NUAK10.63888020
122CDK70.61471954
123AKT20.60059585
124TYK20.59454607
125HCK0.57801910
126PASK0.57563330
127MAPK100.56723492
128PTK20.54931078
129CHEK10.54666887
130MST1R0.54537995
131KIT0.53629857
132PAK30.52554809
133AURKA0.52155403
134PDGFRA0.51581849
135ITK0.51495264
136EIF2AK30.51393464
137DAPK20.50221803
138TAOK10.47750323
139PRKCG0.47141081
140CAMK1D0.45420595
141PIM10.44290771
142TESK10.44256669
143FES0.44173798
144PHKG20.43951915
145PHKG10.43951915
146EIF2AK10.43311595
147CASK0.42756717
148GRK60.41523906
149PAK10.41412569
150SGK10.39613972
151DYRK1A0.39392330
152PRKCI0.38429456
153MAPK30.37958480
154CAMK10.35756212
155MAP3K20.35261053
156CSNK1A10.35072674
157ABL10.35059500
158CAMK1G0.34918064
159DAPK30.34416256
160CAMK40.34359706
161BMPR20.33721689
162PLK30.33145540
163CSNK1A1L0.33129916
164CAMK2A0.31342299
165PRKD30.31318239
166IKBKE0.31035149
167RPS6KA30.30069772
168PRKG20.29140981
169MAPK80.28212751
170MAP2K30.27906649
171CAMK2G0.26772061
172SIK30.26634894
173FYN0.26333500
174CDK20.26308627

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.55874787
2ECM-receptor interaction_Homo sapiens_hsa045123.46751434
3Nicotine addiction_Homo sapiens_hsa050333.17131771
4Long-term potentiation_Homo sapiens_hsa047202.87191261
5Small cell lung cancer_Homo sapiens_hsa052222.59722561
6Amphetamine addiction_Homo sapiens_hsa050312.37493055
7Protein digestion and absorption_Homo sapiens_hsa049742.27584980
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21105672
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.18306533
10Morphine addiction_Homo sapiens_hsa050322.06108941
11Primary immunodeficiency_Homo sapiens_hsa053401.99866805
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.96322067
13Circadian entrainment_Homo sapiens_hsa047131.96123853
14Cocaine addiction_Homo sapiens_hsa050301.94090264
15GABAergic synapse_Homo sapiens_hsa047271.85169798
16Focal adhesion_Homo sapiens_hsa045101.83614400
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82879399
18* Basal cell carcinoma_Homo sapiens_hsa052171.80240442
19Glutamatergic synapse_Homo sapiens_hsa047241.75229771
20* Hedgehog signaling pathway_Homo sapiens_hsa043401.73341545
21Dopaminergic synapse_Homo sapiens_hsa047281.67438425
22Gastric acid secretion_Homo sapiens_hsa049711.66800528
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.64412334
24Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.63851960
25TNF signaling pathway_Homo sapiens_hsa046681.62845859
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62705266
27Amoebiasis_Homo sapiens_hsa051461.61641656
28Glioma_Homo sapiens_hsa052141.60380089
29Cholinergic synapse_Homo sapiens_hsa047251.57353944
30Insulin secretion_Homo sapiens_hsa049111.53591946
31* Proteoglycans in cancer_Homo sapiens_hsa052051.51707103
32GnRH signaling pathway_Homo sapiens_hsa049121.48903231
33* Melanogenesis_Homo sapiens_hsa049161.47735170
34MicroRNAs in cancer_Homo sapiens_hsa052061.46967161
35p53 signaling pathway_Homo sapiens_hsa041151.44760395
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41685040
37Ribosome_Homo sapiens_hsa030101.39013732
38* Hippo signaling pathway_Homo sapiens_hsa043901.38980039
39ErbB signaling pathway_Homo sapiens_hsa040121.37420686
40B cell receptor signaling pathway_Homo sapiens_hsa046621.36824349
41Vitamin B6 metabolism_Homo sapiens_hsa007501.33600942
42Toxoplasmosis_Homo sapiens_hsa051451.33304785
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33178221
44Steroid biosynthesis_Homo sapiens_hsa001001.31426109
45Antigen processing and presentation_Homo sapiens_hsa046121.31103217
46Oocyte meiosis_Homo sapiens_hsa041141.30849424
47* HTLV-I infection_Homo sapiens_hsa051661.30705501
48Chronic myeloid leukemia_Homo sapiens_hsa052201.29834197
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29183039
50Estrogen signaling pathway_Homo sapiens_hsa049151.26806054
51Oxytocin signaling pathway_Homo sapiens_hsa049211.26722822
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26272890
53Bladder cancer_Homo sapiens_hsa052191.26215550
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24073286
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22299009
56Cell cycle_Homo sapiens_hsa041101.21991880
57Apoptosis_Homo sapiens_hsa042101.21393037
58One carbon pool by folate_Homo sapiens_hsa006701.20099700
59Osteoclast differentiation_Homo sapiens_hsa043801.17783195
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.17475755
61Hepatitis B_Homo sapiens_hsa051611.14553917
62Leishmaniasis_Homo sapiens_hsa051401.14483491
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10462398
64PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09780504
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09637543
66Neurotrophin signaling pathway_Homo sapiens_hsa047221.07091634
67cAMP signaling pathway_Homo sapiens_hsa040241.07050456
68Calcium signaling pathway_Homo sapiens_hsa040201.06700305
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05333592
70T cell receptor signaling pathway_Homo sapiens_hsa046601.01114906
71Prostate cancer_Homo sapiens_hsa052151.00530134
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00009385
73Prion diseases_Homo sapiens_hsa050200.98185336
74Gap junction_Homo sapiens_hsa045400.97720645
75* Pathways in cancer_Homo sapiens_hsa052000.97585984
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97354552
77Ovarian steroidogenesis_Homo sapiens_hsa049130.97262535
78Dorso-ventral axis formation_Homo sapiens_hsa043200.96172925
79Acute myeloid leukemia_Homo sapiens_hsa052210.95783883
80Measles_Homo sapiens_hsa051620.94144345
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92761575
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.92647812
83Adherens junction_Homo sapiens_hsa045200.91788312
84Allograft rejection_Homo sapiens_hsa053300.91709184
85Viral carcinogenesis_Homo sapiens_hsa052030.89767987
86Epstein-Barr virus infection_Homo sapiens_hsa051690.89596924
87Salivary secretion_Homo sapiens_hsa049700.89144899
88Alcoholism_Homo sapiens_hsa050340.87734820
89Olfactory transduction_Homo sapiens_hsa047400.86477490
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86408833
91RNA transport_Homo sapiens_hsa030130.84489140
92Endocytosis_Homo sapiens_hsa041440.84323721
93Inositol phosphate metabolism_Homo sapiens_hsa005620.83962690
94Vibrio cholerae infection_Homo sapiens_hsa051100.83442720
95Endometrial cancer_Homo sapiens_hsa052130.83104416
96Choline metabolism in cancer_Homo sapiens_hsa052310.82508323
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.82407885
98Malaria_Homo sapiens_hsa051440.81923087
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81403690
100Hematopoietic cell lineage_Homo sapiens_hsa046400.80804635
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80142802
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80090980
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78291886
104Non-small cell lung cancer_Homo sapiens_hsa052230.78291831
105* Wnt signaling pathway_Homo sapiens_hsa043100.77621685
106Long-term depression_Homo sapiens_hsa047300.77431462
107Collecting duct acid secretion_Homo sapiens_hsa049660.77094221
108Sulfur relay system_Homo sapiens_hsa041220.76782534
109MAPK signaling pathway_Homo sapiens_hsa040100.76399923
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76218191
111HIF-1 signaling pathway_Homo sapiens_hsa040660.76199615
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76113985
113Folate biosynthesis_Homo sapiens_hsa007900.75794684
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75669071
115Tight junction_Homo sapiens_hsa045300.75125833
116* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74937173
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.74025157
118TGF-beta signaling pathway_Homo sapiens_hsa043500.73597134
119Pancreatic cancer_Homo sapiens_hsa052120.73541759
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.73501401
121Colorectal cancer_Homo sapiens_hsa052100.73416268
122Graft-versus-host disease_Homo sapiens_hsa053320.72643962
123FoxO signaling pathway_Homo sapiens_hsa040680.70162522
124Axon guidance_Homo sapiens_hsa043600.69777491
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67928799
126Herpes simplex infection_Homo sapiens_hsa051680.66664456
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66284381
128Notch signaling pathway_Homo sapiens_hsa043300.66278225
129Rap1 signaling pathway_Homo sapiens_hsa040150.66193459
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.65578768
131Hepatitis C_Homo sapiens_hsa051600.64594479
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63744862
133Insulin signaling pathway_Homo sapiens_hsa049100.63592760
134mRNA surveillance pathway_Homo sapiens_hsa030150.62850279
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62607539
136Renin secretion_Homo sapiens_hsa049240.62262855
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61834094
138Viral myocarditis_Homo sapiens_hsa054160.61305331
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60916967
140Prolactin signaling pathway_Homo sapiens_hsa049170.60801023
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.60762980
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60516972
143Type II diabetes mellitus_Homo sapiens_hsa049300.60074743
144Platelet activation_Homo sapiens_hsa046110.59533325
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58347324
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58039263
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57662368
148Ras signaling pathway_Homo sapiens_hsa040140.57413245
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56882723
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56504539
151Vitamin digestion and absorption_Homo sapiens_hsa049770.56124601
152Taste transduction_Homo sapiens_hsa047420.54690281
153DNA replication_Homo sapiens_hsa030300.54077250
154Thyroid cancer_Homo sapiens_hsa052160.53330060
155RNA polymerase_Homo sapiens_hsa030200.52300136
156mTOR signaling pathway_Homo sapiens_hsa041500.51727819
157Biosynthesis of amino acids_Homo sapiens_hsa012300.51705252
158Shigellosis_Homo sapiens_hsa051310.51088790
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49964118
160Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49472173
161Renal cell carcinoma_Homo sapiens_hsa052110.49142419
162Vascular smooth muscle contraction_Homo sapiens_hsa042700.48943989
163Glucagon signaling pathway_Homo sapiens_hsa049220.48196699
164Dilated cardiomyopathy_Homo sapiens_hsa054140.48022673
165Base excision repair_Homo sapiens_hsa034100.46773218
166VEGF signaling pathway_Homo sapiens_hsa043700.45899413
167Insulin resistance_Homo sapiens_hsa049310.45705263
168Arginine biosynthesis_Homo sapiens_hsa002200.44555695
169Thyroid hormone synthesis_Homo sapiens_hsa049180.43327028
170Spliceosome_Homo sapiens_hsa030400.42878838

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