WNT16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-threonine dephosphorylation (GO:0035970)6.89988686
2* keratinocyte proliferation (GO:0043616)6.73192553
3motile cilium assembly (GO:0044458)6.26674735
4hemidesmosome assembly (GO:0031581)6.11706578
5regulation of pigment cell differentiation (GO:0050932)5.87321525
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.73325579
7axon extension involved in axon guidance (GO:0048846)5.73325579
8bone trabecula formation (GO:0060346)5.72840402
9positive regulation of developmental pigmentation (GO:0048087)5.30686406
10collagen fibril organization (GO:0030199)5.09884487
11sequestering of extracellular ligand from receptor (GO:0035581)4.85000653
12negative regulation of axon extension involved in axon guidance (GO:0048843)4.83243129
13regulation of translational termination (GO:0006449)4.74622003
14regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.73591722
15negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.63125383
16negative regulation of smooth muscle cell differentiation (GO:0051151)4.60107206
17establishment of skin barrier (GO:0061436)4.54026534
18mammary gland epithelial cell proliferation (GO:0033598)4.52993782
19respiratory tube development (GO:0030323)4.52814242
20keratinization (GO:0031424)4.50043977
21sensory perception of smell (GO:0007608)4.45506678
22wound healing, spreading of epidermal cells (GO:0035313)4.44141000
23ribosome assembly (GO:0042255)4.32812437
24regulation of acyl-CoA biosynthetic process (GO:0050812)4.28418847
25chondrocyte proliferation (GO:0035988)4.26663034
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.21787634
27negative regulation of axon guidance (GO:1902668)4.19996319
28protein heterotrimerization (GO:0070208)4.11594626
29endodermal cell differentiation (GO:0035987)4.06607448
30negative regulation of fatty acid transport (GO:2000192)4.06084392
31regulation of cofactor metabolic process (GO:0051193)3.98866551
32regulation of coenzyme metabolic process (GO:0051196)3.98866551
33regulation of sulfur metabolic process (GO:0042762)3.97878110
34nuclear pore complex assembly (GO:0051292)3.96166359
35centriole assembly (GO:0098534)3.94080695
36response to methylmercury (GO:0051597)3.86521459
37desmosome organization (GO:0002934)3.83662096
38lung vasculature development (GO:0060426)3.81632418
39detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.80708681
40mesodermal cell differentiation (GO:0048333)3.80116435
41wound healing, spreading of cells (GO:0044319)3.73986904
42regulation of glomerular filtration (GO:0003093)3.69476384
43regulation of axon extension involved in axon guidance (GO:0048841)3.68365758
44* keratinocyte differentiation (GO:0030216)3.67423277
45hypotonic response (GO:0006971)3.65363526
46regulation of water loss via skin (GO:0033561)3.64688481
47cell adhesion mediated by integrin (GO:0033627)3.61837847
48positive regulation of Rho protein signal transduction (GO:0035025)3.53026903
49extracellular negative regulation of signal transduction (GO:1900116)3.51861663
50extracellular regulation of signal transduction (GO:1900115)3.51861663
51formation of translation preinitiation complex (GO:0001731)3.45615279
52regulation of hippo signaling (GO:0035330)3.45508354
53skin morphogenesis (GO:0043589)3.44199984
54regulation of axon guidance (GO:1902667)3.40956336
55planar cell polarity pathway involved in neural tube closure (GO:0090179)3.39141800
56positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.38294037
57regulation of smooth muscle cell differentiation (GO:0051150)3.37056179
58positive regulation of fibroblast migration (GO:0010763)3.37052155
59negative chemotaxis (GO:0050919)3.36275323
60activation of Rac GTPase activity (GO:0032863)3.34135053
61negative regulation of DNA repair (GO:0045738)3.33151583
62positive regulation of endothelial cell apoptotic process (GO:2000353)3.32192465
63ribosomal large subunit biogenesis (GO:0042273)3.29723629
64positive regulation of Ras protein signal transduction (GO:0046579)3.29008935
65regulation of protein export from nucleus (GO:0046825)3.26581808
66nuclear pore organization (GO:0006999)3.25477111
67substrate-dependent cell migration (GO:0006929)3.23115975
68mitotic sister chromatid cohesion (GO:0007064)3.20675234
69establishment of integrated proviral latency (GO:0075713)3.19821152
70negative regulation of activin receptor signaling pathway (GO:0032926)3.18084749
71collagen metabolic process (GO:0032963)3.17987753
72collagen catabolic process (GO:0030574)3.17123492
73regulation of protein kinase A signaling (GO:0010738)3.16983918
74positive regulation of cardiac muscle cell differentiation (GO:2000727)3.16278365
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15713856
76rRNA catabolic process (GO:0016075)3.14344695
77cell-substrate junction assembly (GO:0007044)3.13414464
78cerebral cortex radially oriented cell migration (GO:0021799)3.13030980
79cellular response to vitamin D (GO:0071305)3.12496823
80regulation of fibroblast apoptotic process (GO:2000269)3.12255806
81response to insecticide (GO:0017085)3.09611028
82histone-serine phosphorylation (GO:0035404)3.09260651
83negative regulation of chondrocyte differentiation (GO:0032331)3.08959017
84bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08344274
85dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.06032962
86multicellular organismal macromolecule metabolic process (GO:0044259)3.03603754
87negative regulation of glial cell proliferation (GO:0060253)3.03216962
88natural killer cell mediated immunity (GO:0002228)3.02414820
89natural killer cell mediated cytotoxicity (GO:0042267)3.02414820
90negative regulation of cell fate specification (GO:0009996)3.02194934
91chaperone-mediated protein complex assembly (GO:0051131)3.01687163
92positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.00447881
93cellular response to vitamin (GO:0071295)2.99707803
94negative regulation of keratinocyte proliferation (GO:0010839)2.99265910
95positive regulation of cytokinesis (GO:0032467)2.98084553
96axis elongation (GO:0003401)2.97084351
97regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.96943790
98cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.96334424
99limb bud formation (GO:0060174)2.95438434
100G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.93372577
101regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.92881795
102positive regulation of insulin receptor signaling pathway (GO:0046628)2.92136274
103substrate-independent telencephalic tangential migration (GO:0021826)2.91925954
104substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.91925954
105positive regulation of small GTPase mediated signal transduction (GO:0051057)2.91197772
106regulation of mitotic spindle organization (GO:0060236)2.90904838
107histone H2B ubiquitination (GO:0033523)2.90443695
108positive regulation of epithelial to mesenchymal transition (GO:0010718)2.90332744
109protein heterotetramerization (GO:0051290)2.89240402
110protoporphyrinogen IX biosynthetic process (GO:0006782)2.88854250
111cardiac right ventricle morphogenesis (GO:0003215)2.88321953
112endocardial cushion development (GO:0003197)2.88017406
113negative regulation of protein tyrosine kinase activity (GO:0061099)2.87888258
114craniofacial suture morphogenesis (GO:0097094)2.87492500
115mitochondrial DNA replication (GO:0006264)2.87416380
116cornea development in camera-type eye (GO:0061303)2.86905972
117negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.86684399
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86179075
119cellular response to interferon-alpha (GO:0035457)2.85882699
120response to X-ray (GO:0010165)2.85763485
121heterochromatin organization (GO:0070828)2.85543972
122negative regulation of myeloid cell apoptotic process (GO:0033033)2.85470220
123regulation of centriole replication (GO:0046599)2.85363888
124extracellular matrix assembly (GO:0085029)2.84613637
125multicellular organismal catabolic process (GO:0044243)2.84129894
126G1 DNA damage checkpoint (GO:0044783)2.83144332
127mitotic cytokinesis (GO:0000281)2.81594220
128positive regulation of protein export from nucleus (GO:0046827)2.81586357
129extracellular matrix disassembly (GO:0022617)2.81408301
130regulation of cardioblast differentiation (GO:0051890)2.80926303
131multicellular organismal metabolic process (GO:0044236)2.80414077
132negative regulation of stem cell proliferation (GO:2000647)2.77867703
133regulation of developmental pigmentation (GO:0048070)2.77054192
134negative regulation of cell fate commitment (GO:0010454)2.76915233
135notochord development (GO:0030903)2.76476447
136cellular response to prostaglandin stimulus (GO:0071379)2.76473385
137positive regulation of stem cell differentiation (GO:2000738)2.76434459
138cytoskeleton-dependent cytokinesis (GO:0061640)2.75969401
139* epidermal cell differentiation (GO:0009913)2.75963591
140mitotic metaphase plate congression (GO:0007080)2.75324846
141sympathetic nervous system development (GO:0048485)2.75248214
142negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.74921120
143protoporphyrinogen IX metabolic process (GO:0046501)2.74838192
144eyelid development in camera-type eye (GO:0061029)2.74249917
145mammary gland alveolus development (GO:0060749)2.72896099
146mesenchymal cell differentiation involved in renal system development (GO:2001012)2.72873437
147mesenchymal cell differentiation involved in kidney development (GO:0072161)2.72873437
148positive regulation of gastrulation (GO:2000543)2.72795126
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72447561
150glomerular visceral epithelial cell development (GO:0072015)2.72314995
151omega-hydroxylase P450 pathway (GO:0097267)2.72201204
152pore complex assembly (GO:0046931)2.70976616
153mitotic chromosome condensation (GO:0007076)2.70443325
154response to lead ion (GO:0010288)2.66508515
155heart valve morphogenesis (GO:0003179)2.66446956
156gland morphogenesis (GO:0022612)2.66307917
157negative regulation of leukocyte chemotaxis (GO:0002689)2.66234682
158positive regulation of DNA replication (GO:0045740)2.66137282
159negative regulation of embryonic development (GO:0045992)2.65100028
160protein K6-linked ubiquitination (GO:0085020)2.64749130
161ribosome biogenesis (GO:0042254)2.64295681
162mesenchymal-epithelial cell signaling (GO:0060638)2.62627029
163cytokine production involved in immune response (GO:0002367)2.61745253
164nucleobase-containing small molecule interconversion (GO:0015949)2.61640117
165regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61416061
166regulation of establishment of planar polarity (GO:0090175)2.61086823
167lateral sprouting from an epithelium (GO:0060601)2.60934941
168regulation of translational fidelity (GO:0006450)2.59383931
169negative regulation of cartilage development (GO:0061037)2.59256922
170metanephric mesenchyme development (GO:0072075)2.57385380
171epithelial cell-cell adhesion (GO:0090136)2.57265333
172regulation of integrin activation (GO:0033623)2.55969355
173non-canonical Wnt signaling pathway (GO:0035567)2.55545485
174negative regulation of fibroblast apoptotic process (GO:2000270)2.54936222
175regulation of keratinocyte proliferation (GO:0010837)2.54637658
176glomerular basement membrane development (GO:0032836)2.54570893
177trabecula formation (GO:0060343)2.54196061
178positive regulation of cellular response to insulin stimulus (GO:1900078)2.53839610
179regulation of centrosome duplication (GO:0010824)2.53640712
180maturation of 5.8S rRNA (GO:0000460)2.53108017
181response to arsenic-containing substance (GO:0046685)2.53070016
182regulation of monocyte chemotaxis (GO:0090025)2.51639273
183regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.50607440
184facial nerve structural organization (GO:0021612)2.48930128
185presynaptic membrane assembly (GO:0097105)2.48844960
186smooth muscle tissue development (GO:0048745)2.46588803
187regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.46148053
188positive regulation of catenin import into nucleus (GO:0035413)2.45617059
189regulation of chemokine-mediated signaling pathway (GO:0070099)2.45370897
190extracellular matrix organization (GO:0030198)2.43518033
191regulation of endothelial cell apoptotic process (GO:2000351)2.43032358
192extracellular structure organization (GO:0043062)2.42621620
193positive regulation of bone mineralization (GO:0030501)2.40602090
194embryonic cranial skeleton morphogenesis (GO:0048701)2.39577348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.20424335
2E2F7_22180533_ChIP-Seq_HELA_Human5.32266863
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.84772718
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.83890574
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.77721072
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.22319877
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.11330229
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.99233002
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79425813
10EZH2_22144423_ChIP-Seq_EOC_Human2.73569532
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.67143786
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.56112726
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49306433
14DCP1A_22483619_ChIP-Seq_HELA_Human2.44399519
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42556338
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39995218
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35055259
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31682332
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30145766
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30145766
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28338109
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27567551
23* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24796226
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.20178056
25AR_21909140_ChIP-Seq_LNCAP_Human2.19655165
26ELK1_19687146_ChIP-ChIP_HELA_Human2.18467556
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17726588
28* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15943018
29ATF3_27146783_Chip-Seq_COLON_Human2.14372319
30FOXO3_23340844_ChIP-Seq_DLD1_Human2.14132055
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11264315
32* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10578695
33GBX2_23144817_ChIP-Seq_PC3_Human2.01452854
34* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.98492513
35* TP53_20018659_ChIP-ChIP_R1E_Mouse1.92475230
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.90652702
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90180640
38AR_21572438_ChIP-Seq_LNCaP_Human1.89762957
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87973595
40* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87114248
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85514841
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81860045
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81369905
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78881162
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.75356722
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.73502227
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73096574
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72438491
49TP53_18474530_ChIP-ChIP_U2OS_Human1.70781171
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69610909
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.69537117
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.68095223
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67697786
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66814583
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65155008
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64873912
57EWS_26573619_Chip-Seq_HEK293_Human1.61632431
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60899495
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60872353
60CJUN_26792858_Chip-Seq_BT549_Human1.60030190
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58791295
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58216776
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57236086
64FUS_26573619_Chip-Seq_HEK293_Human1.57046689
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.56876515
66TP53_16413492_ChIP-PET_HCT116_Human1.56582863
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56368460
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50812970
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50004069
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48542854
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46841222
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46431909
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45554413
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.45239066
75* PIAS1_25552417_ChIP-Seq_VCAP_Human1.44928337
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43064612
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42177827
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.41800705
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41082938
80* EP300_21415370_ChIP-Seq_HL-1_Mouse1.40233609
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.39346549
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38056410
83TTF2_22483619_ChIP-Seq_HELA_Human1.35442917
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33386524
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33042483
86* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32901462
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32502410
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32107231
89TP53_22127205_ChIP-Seq_IMR90_Human1.31380338
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30425685
91* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29045816
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29015587
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28087845
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27791802
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.27113592
96VDR_23849224_ChIP-Seq_CD4+_Human1.26751272
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23968447
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23785515
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22812423
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22792604
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21799029
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21716947
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21694479
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21678377
105AHR_22903824_ChIP-Seq_MCF-7_Human1.18914868
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16973660
107RXR_22108803_ChIP-Seq_LS180_Human1.16929111
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.16349679
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15707282
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.14367732
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14169861
112* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13901385
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13637711
114TCF4_18268006_ChIP-ChIP_LS174T_Human1.12927218
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.12411476
116UBF1/2_26484160_Chip-Seq_HMECs_Human1.11191635
117XRN2_22483619_ChIP-Seq_HELA_Human1.10733708
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10031318
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.08879393
120DROSHA_22980978_ChIP-Seq_HELA_Human1.07509691
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07352600
122* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07142043
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05884919
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05884919
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05398715
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03576103
127SOX17_20123909_ChIP-Seq_XEN_Mouse1.03315836
128* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03095425
129* CDX2_22108803_ChIP-Seq_LS180_Human1.02543047
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00632703
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00632703
132BRD4_25478319_ChIP-Seq_HGPS_Human1.00516484
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00238004
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00154713
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99607127
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99153770
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99083507
138* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98010978
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97505554
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97279413
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96239198
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94887986
143ISL1_27105846_Chip-Seq_CPCs_Mouse0.94515180
144P300_19829295_ChIP-Seq_ESCs_Human0.94402408
145SMAD4_21799915_ChIP-Seq_A2780_Human0.94189666
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93912941
147EST1_17652178_ChIP-ChIP_JURKAT_Human0.93429074
148SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93190201
149ELK1_22589737_ChIP-Seq_MCF10A_Human0.93119803
150REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92597310
151BCAT_22108803_ChIP-Seq_LS180_Human0.92039040
152HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91907175
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91648222
154SOX2_20726797_ChIP-Seq_SW620_Human0.91606477
155KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91490599
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89019654
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88969161
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88969161
159ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88914088
160MYC_18940864_ChIP-ChIP_HL60_Human0.88904232
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.88895145
162AR_25329375_ChIP-Seq_VCAP_Human0.88172046
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87384761
164* RNF2_27304074_Chip-Seq_NSC_Mouse0.87286280
165ZNF263_19887448_ChIP-Seq_K562_Human0.86549521
166TP53_23651856_ChIP-Seq_MEFs_Mouse0.85817445
167GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85805542
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85404129
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.85227372
170KLF5_25053715_ChIP-Seq_YYC3_Human0.84827412
171SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84597289
172GABP_19822575_ChIP-Seq_HepG2_Human0.84120717
173TP63_23658742_ChIP-Seq_EP156T_Human0.83456008
174VDR_22108803_ChIP-Seq_LS180_Human0.82767055
175CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82324021
176PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81308739
177P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79570306
178OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79430606
179TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79086906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.36784650
2MP0005275_abnormal_skin_tensile4.78356314
3MP0005503_abnormal_tendon_morphology4.35137556
4MP0010234_abnormal_vibrissa_follicle4.13004008
5MP0008961_abnormal_basal_metabolism4.08328568
6MP0004185_abnormal_adipocyte_glucose3.66819421
7MP0003941_abnormal_skin_development3.62449776
8MP0009379_abnormal_foot_pigmentation3.58107792
9MP0003705_abnormal_hypodermis_morpholog3.15933970
10MP0002060_abnormal_skin_morphology2.98433994
11MP0001188_hyperpigmentation2.88218421
12MP0002877_abnormal_melanocyte_morpholog2.83032108
13MP0009697_abnormal_copulation2.77917635
14MP0003279_aneurysm2.62945964
15MP0001958_emphysema2.62300574
16MP0005623_abnormal_meninges_morphology2.58847802
17MP0004272_abnormal_basement_membrane2.55393469
18MP0003566_abnormal_cell_adhesion2.48307076
19MP0009384_cardiac_valve_regurgitation2.46191554
20MP0005257_abnormal_intraocular_pressure2.41097070
21MP0010094_abnormal_chromosome_stability2.40690236
22MP0003385_abnormal_body_wall2.16226252
23MP0005508_abnormal_skeleton_morphology2.15132927
24MP0000566_synostosis2.09854126
25MP0008057_abnormal_DNA_replication1.96629692
26MP0009250_abnormal_appendicular_skeleto1.93303249
27MP0004957_abnormal_blastocyst_morpholog1.89246247
28MP0003077_abnormal_cell_cycle1.87754789
29MP0001348_abnormal_lacrimal_gland1.79945451
30MP0000467_abnormal_esophagus_morphology1.68352095
31MP0003942_abnormal_urinary_system1.66259731
32MP0003111_abnormal_nucleus_morphology1.61560012
33MP0010030_abnormal_orbit_morphology1.61094750
34MP0009780_abnormal_chondrocyte_physiolo1.59565102
35MP0000383_abnormal_hair_follicle1.59267557
36MP0004808_abnormal_hematopoietic_stem1.58894466
37MP0002108_abnormal_muscle_morphology1.58402733
38MP0004134_abnormal_chest_morphology1.56888620
39MP0000762_abnormal_tongue_morphology1.50222941
40MP0002295_abnormal_pulmonary_circulatio1.47915196
41MP0006054_spinal_hemorrhage1.45075769
42MP0003755_abnormal_palate_morphology1.45072728
43MP0001986_abnormal_taste_sensitivity1.42497551
44MP0010771_integument_phenotype1.40762023
45MP0000579_abnormal_nail_morphology1.38908426
46MP0000350_abnormal_cell_proliferation1.34558553
47MP0005023_abnormal_wound_healing1.34123444
48MP0004381_abnormal_hair_follicle1.33988586
49MP0004947_skin_inflammation1.32767576
50MP0001243_abnormal_dermal_layer1.32523197
51MP0002282_abnormal_trachea_morphology1.29954389
52MP0001542_abnormal_bone_strength1.28968348
53MP0009053_abnormal_anal_canal1.28130396
54MP0002095_abnormal_skin_pigmentation1.28011536
55MP0002896_abnormal_bone_mineralization1.25908484
56MP0010352_gastrointestinal_tract_polyps1.25841340
57MP0002998_abnormal_bone_remodeling1.25479341
58MP0003453_abnormal_keratinocyte_physiol1.24929883
59MP0003091_abnormal_cell_migration1.21945515
60MP0008932_abnormal_embryonic_tissue1.19599000
61MP0005174_abnormal_tail_pigmentation1.19086414
62MP0000627_abnormal_mammary_gland1.19039020
63MP0002233_abnormal_nose_morphology1.18835718
64MP0002933_joint_inflammation1.17734054
65MP0001299_abnormal_eye_distance/1.17712362
66MP0008058_abnormal_DNA_repair1.17283003
67MP0003315_abnormal_perineum_morphology1.16943912
68MP0002092_abnormal_eye_morphology1.15731216
69MP0005171_absent_coat_pigmentation1.15395493
70MP0000049_abnormal_middle_ear1.15105762
71MP0002796_impaired_skin_barrier1.13731665
72MP0000767_abnormal_smooth_muscle1.12071888
73MP0005390_skeleton_phenotype1.11823207
74MP0002932_abnormal_joint_morphology1.11737678
75MP0001177_atelectasis1.11685844
76MP0003045_fibrosis1.11526087
77MP0001340_abnormal_eyelid_morphology1.10997967
78MP0003136_yellow_coat_color1.10121122
79MP0005501_abnormal_skin_physiology1.09983872
80MP0000534_abnormal_ureter_morphology1.09205787
81MP0008007_abnormal_cellular_replicative1.08585701
82MP0003828_pulmonary_edema1.05592475
83MP0003786_premature_aging1.05581552
84MP0000462_abnormal_digestive_system1.04324570
85MP0002102_abnormal_ear_morphology1.03880996
86MP0000537_abnormal_urethra_morphology1.03162999
87MP0002009_preneoplasia1.02737789
88MP0000013_abnormal_adipose_tissue1.02710993
89MP0002115_abnormal_skeleton_extremities1.02434231
90MP0000490_abnormal_crypts_of1.02133713
91MP0003656_abnormal_erythrocyte_physiolo1.01812441
92MP0002970_abnormal_white_adipose1.01677311
93MP0002109_abnormal_limb_morphology1.01669907
94MP0002638_abnormal_pupillary_reflex1.01584398
95MP0010678_abnormal_skin_adnexa1.01102487
96MP0000432_abnormal_head_morphology1.00913015
97MP0004197_abnormal_fetal_growth/weight/1.00538843
98MP0000428_abnormal_craniofacial_morphol0.98553389
99MP0001881_abnormal_mammary_gland0.98099856
100MP0002116_abnormal_craniofacial_bone0.97121294
101MP0002098_abnormal_vibrissa_morphology0.96949398
102MP0005409_darkened_coat_color0.95028274
103MP0003937_abnormal_limbs/digits/tail_de0.94464555
104MP0002160_abnormal_reproductive_system0.94351923
105MP0001730_embryonic_growth_arrest0.93634906
106MP0005164_abnormal_response_to0.93426921
107MP0002249_abnormal_larynx_morphology0.92367453
108MP0003252_abnormal_bile_duct0.92167166
109MP0000163_abnormal_cartilage_morphology0.91516973
110MP0010307_abnormal_tumor_latency0.91393207
111MP0000647_abnormal_sebaceous_gland0.91021333
112MP0000377_abnormal_hair_follicle0.90584991
113MP0005595_abnormal_vascular_smooth0.90274634
114MP0001346_abnormal_lacrimal_gland0.90261547
115MP0002396_abnormal_hematopoietic_system0.89181688
116MP0001849_ear_inflammation0.88635222
117MP0003123_paternal_imprinting0.87921229
118MP0001873_stomach_inflammation0.87629965
119MP0002113_abnormal_skeleton_development0.87269483
120MP0003283_abnormal_digestive_organ0.86391762
121MP0002177_abnormal_outer_ear0.85443953
122MP0002089_abnormal_postnatal_growth/wei0.84956556
123MP0000427_abnormal_hair_cycle0.83666669
124MP0002697_abnormal_eye_size0.83586588
125MP0001286_abnormal_eye_development0.83362365
126MP0002133_abnormal_respiratory_system0.82868009
127MP0005388_respiratory_system_phenotype0.82868009
128MP0001697_abnormal_embryo_size0.82702594
129MP0004858_abnormal_nervous_system0.82311517
130MP0002234_abnormal_pharynx_morphology0.82303845
131MP0002084_abnormal_developmental_patter0.81862610
132MP0003221_abnormal_cardiomyocyte_apopto0.81101911
133MP0001915_intracranial_hemorrhage0.80984990
134MP0001216_abnormal_epidermal_layer0.80763470
135MP0000015_abnormal_ear_pigmentation0.79833358
136MP0005197_abnormal_uvea_morphology0.79372368
137MP0002168_other_aberrant_phenotype0.78914007
138MP0002254_reproductive_system_inflammat0.77436348
139MP0003938_abnormal_ear_development0.76799588
140MP0003935_abnormal_craniofacial_develop0.76214868
141MP0000569_abnormal_digit_pigmentation0.74385132
142MP0003693_abnormal_embryo_hatching0.74308875
143MP0003936_abnormal_reproductive_system0.73953213
144MP0001191_abnormal_skin_condition0.71168479
145MP0008874_decreased_physiological_sensi0.69800499
146MP0005380_embryogenesis_phenotype0.69678079
147MP0001672_abnormal_embryogenesis/_devel0.69678079
148MP0005666_abnormal_adipose_tissue0.68987919
149MP0002114_abnormal_axial_skeleton0.68930093
150MP0002086_abnormal_extraembryonic_tissu0.68807017
151MP0003191_abnormal_cellular_cholesterol0.68399366
152MP0003122_maternal_imprinting0.68303027
153MP0005621_abnormal_cell_physiology0.68010813
154MP0002971_abnormal_brown_adipose0.67629383
155MP0000358_abnormal_cell_content/0.67310489
156MP0002085_abnormal_embryonic_tissue0.66792303
157MP0005076_abnormal_cell_differentiation0.66610799
158MP0001293_anophthalmia0.66466610
159MP0005193_abnormal_anterior_eye0.65839985

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.85957838
2Protrusio acetabuli (HP:0003179)6.44707502
3Atrophic scars (HP:0001075)6.09133504
4Morphological abnormality of the middle ear (HP:0008609)5.27207852
5Progressive external ophthalmoplegia (HP:0000590)5.01876797
6Fragile skin (HP:0001030)4.87282251
7Shallow orbits (HP:0000586)4.82429102
8Insomnia (HP:0100785)4.53195586
9Peritonitis (HP:0002586)4.47381644
10Aortic dissection (HP:0002647)4.28368797
11Absent eyelashes (HP:0000561)4.22061062
12Absent eyebrow (HP:0002223)4.14690474
13Thin bony cortex (HP:0002753)4.03448300
14Soft skin (HP:0000977)3.90226736
15Sensory axonal neuropathy (HP:0003390)3.68310328
16Chromsome breakage (HP:0040012)3.66285538
17Diaphragmatic weakness (HP:0009113)3.58694988
18Abnormality of dentin (HP:0010299)3.58421839
19Selective tooth agenesis (HP:0001592)3.50400627
20Neonatal short-limb short stature (HP:0008921)3.42803102
21Dilatation of the ascending aorta (HP:0005111)3.37646307
22Conjunctival hamartoma (HP:0100780)3.37486201
23Gastrointestinal stroma tumor (HP:0100723)3.34966581
24Broad metatarsal (HP:0001783)3.32588790
25Bladder diverticulum (HP:0000015)3.31039598
26Milia (HP:0001056)3.18169751
27Ankle contracture (HP:0006466)3.15380460
28Confusion (HP:0001289)3.10897707
29Erythroderma (HP:0001019)2.98792807
30Submucous cleft hard palate (HP:0000176)2.95555081
31Wrist flexion contracture (HP:0001239)2.95152997
32Natal tooth (HP:0000695)2.93386440
33Fragile nails (HP:0001808)2.92110096
34Abnormality of nail color (HP:0100643)2.90007005
35Asymmetry of the thorax (HP:0001555)2.89250280
36Hyperextensible skin (HP:0000974)2.87367376
37Hypotrichosis (HP:0001006)2.86437717
38Genu recurvatum (HP:0002816)2.81896049
39Tibial bowing (HP:0002982)2.80362153
40Pili torti (HP:0003777)2.79801134
41Ectopia lentis (HP:0001083)2.78933980
42Palmoplantar hyperkeratosis (HP:0000972)2.78920885
43Palmar hyperkeratosis (HP:0010765)2.76861066
44Abnormality of secondary sexual hair (HP:0009888)2.74298390
45Abnormality of the axillary hair (HP:0100134)2.74298390
46Microglossia (HP:0000171)2.73546551
47Blue sclerae (HP:0000592)2.73030655
48Femoral bowing (HP:0002980)2.69197358
49Corneal erosion (HP:0200020)2.68877642
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68285169
51Hallux valgus (HP:0001822)2.67657194
52Aortic aneurysm (HP:0004942)2.67277694
53Deviation of the hallux (HP:0010051)2.65331703
54Xerostomia (HP:0000217)2.63175254
55Cutaneous finger syndactyly (HP:0010554)2.63172318
56Mitral valve prolapse (HP:0001634)2.62522903
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.61752804
58Flat cornea (HP:0007720)2.60163624
59Abnormality of the preputium (HP:0100587)2.56914459
60Aplasia involving bones of the upper limbs (HP:0009823)2.56583276
61Aplasia of the phalanges of the hand (HP:0009802)2.56583276
62Aplasia involving bones of the extremities (HP:0009825)2.56583276
63Abnormality of the umbilical cord (HP:0010881)2.55859137
64Bowel diverticulosis (HP:0005222)2.49260317
65Midline defect of the nose (HP:0004122)2.41754615
66Mildly elevated creatine phosphokinase (HP:0008180)2.41322298
67Congenital ichthyosiform erythroderma (HP:0007431)2.39306142
68Abnormality of chromosome stability (HP:0003220)2.36949903
69Vertebral arch anomaly (HP:0008438)2.36764142
70Entropion (HP:0000621)2.36287768
71Congenital, generalized hypertrichosis (HP:0004540)2.36064593
72Vascular tortuosity (HP:0004948)2.33433866
73Infantile muscular hypotonia (HP:0008947)2.33411769
74Horizontal nystagmus (HP:0000666)2.32762053
75Overgrowth (HP:0001548)2.31903104
76Missing ribs (HP:0000921)2.31295207
77Erythema (HP:0010783)2.29958944
78Elbow flexion contracture (HP:0002987)2.28054763
79Reduced subcutaneous adipose tissue (HP:0003758)2.27244056
80Persistence of primary teeth (HP:0006335)2.26070466
81Increased density of long bones (HP:0006392)2.26034750
82Wormian bones (HP:0002645)2.25272586
83Melanocytic nevus (HP:0000995)2.22406315
84Hypoplasia of the pons (HP:0012110)2.19678668
85Abnormality of the fetal cardiovascular system (HP:0010948)2.18776500
86Abnormal umbilical cord blood vessels (HP:0011403)2.18776500
87Single umbilical artery (HP:0001195)2.18776500
88Progressive muscle weakness (HP:0003323)2.18722344
89Coronal craniosynostosis (HP:0004440)2.18204100
90Keratoconus (HP:0000563)2.17713845
91Increased corneal curvature (HP:0100692)2.17713845
92Broad ribs (HP:0000885)2.16496169
93Adrenal hypoplasia (HP:0000835)2.16003498
94Hyponatremia (HP:0002902)2.15049662
95Advanced eruption of teeth (HP:0006288)2.12916902
96Abnormality of sodium homeostasis (HP:0010931)2.11216060
97Cerebral aneurysm (HP:0004944)2.10328014
98Abnormal delivery (HP:0001787)2.10082827
99Woolly hair (HP:0002224)2.08572112
100Abnormality of the nasolacrimal system (HP:0000614)2.08247578
101Cutaneous syndactyly (HP:0012725)2.07168868
102Wide anterior fontanel (HP:0000260)2.06854313
103Sparse eyelashes (HP:0000653)2.06832388
104Abnormality of the pons (HP:0007361)2.06334713
105Abnormality of the costochondral junction (HP:0000919)2.06051316
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04830033
107Absent hair (HP:0002298)2.04147929
108Abnormality of the peritoneum (HP:0002585)2.02308287
109Proximal placement of thumb (HP:0009623)2.02269554
110Alveolar cell carcinoma (HP:0006519)2.02079613
111Progressive inability to walk (HP:0002505)2.01149296
112Congenital glaucoma (HP:0001087)2.01001249
113Spinal rigidity (HP:0003306)2.00781759
114Mitral regurgitation (HP:0001653)1.99077917
115Duodenal stenosis (HP:0100867)1.98771682
116Small intestinal stenosis (HP:0012848)1.98771682
117Abnormality of the lacrimal duct (HP:0011481)1.98357907
118Biconcave vertebral bodies (HP:0004586)1.98049335
119Abnormality of the gastric mucosa (HP:0004295)1.96497845
120Follicular hyperkeratosis (HP:0007502)1.95971778
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.95217830
122Alopecia of scalp (HP:0002293)1.95125164
123Chronic bronchitis (HP:0004469)1.93560877
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92854018
125Conjugated hyperbilirubinemia (HP:0002908)1.92565524
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91907811
127Plantar hyperkeratosis (HP:0007556)1.91844543
128Round ear (HP:0100830)1.91844098
129Camptodactyly of toe (HP:0001836)1.91811019
130Onycholysis (HP:0001806)1.90634171
131Hamartoma of the eye (HP:0010568)1.90296752
132Buphthalmos (HP:0000557)1.90134145
133Bifid tongue (HP:0010297)1.90125609
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.90108820
135Dysphonia (HP:0001618)1.90079086
136Poikiloderma (HP:0001029)1.89803865
137Meckel diverticulum (HP:0002245)1.87072046
138Arterial tortuosity (HP:0005116)1.86122380
139Achilles tendon contracture (HP:0001771)1.85993407
140Hypoplasia of the iris (HP:0007676)1.85314521
141Venous insufficiency (HP:0005293)1.84877403
142Verrucae (HP:0200043)1.83096166
143Papilloma (HP:0012740)1.83096166
144Bilateral microphthalmos (HP:0007633)1.82636218
145Abnormality of the carotid arteries (HP:0005344)1.81716968
146Deviation of the thumb (HP:0009603)1.79907628
147Venous abnormality (HP:0002624)1.79791458
148Vertebral compression fractures (HP:0002953)1.79402328
149Impaired proprioception (HP:0010831)1.78985168
150Abnormality of the ileum (HP:0001549)1.78097988
151Abnormality of the anterior chamber (HP:0000593)1.77827158
152Aplasia cutis congenita (HP:0001057)1.77698427
153Knee flexion contracture (HP:0006380)1.77577225
154Premature ovarian failure (HP:0008209)1.77549503
155Mesomelia (HP:0003027)1.76039468
156Neoplasm of the tracheobronchial system (HP:0100552)1.75961260
157Abnormalities of placenta or umbilical cord (HP:0001194)1.75611624
158Abnormal hair laboratory examination (HP:0003328)1.75552694
159Choanal stenosis (HP:0000452)1.75439126
160Trismus (HP:0000211)1.73865681
161Redundant skin (HP:0001582)1.73793926
162Joint laxity (HP:0001388)1.73384550
163Thick nail (HP:0001805)1.73215691
164Right ventricular cardiomyopathy (HP:0011663)1.73084251
165Myelomeningocele (HP:0002475)1.72917359
166Abnormality of the parietal bone (HP:0002696)1.72191036
167Palpitations (HP:0001962)1.71837542
168Abnormality of the intrinsic pathway (HP:0010989)1.71461327
169Ridged nail (HP:0001807)1.71339427
170Termporal pattern (HP:0011008)1.71264035
171Nonimmune hydrops fetalis (HP:0001790)1.70685448
172Thin skin (HP:0000963)1.70494623
173Disproportionate tall stature (HP:0001519)1.69692432
174Spinal canal stenosis (HP:0003416)1.69663207
175Bicornuate uterus (HP:0000813)1.68388580
176Hip contracture (HP:0003273)1.68111571
177Type 1 muscle fiber predominance (HP:0003803)1.68106536
178Spinal cord lesions (HP:0100561)1.67389177
179Syringomyelia (HP:0003396)1.67389177
180Premature loss of primary teeth (HP:0006323)1.67096787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST47.36309011
2AKT37.05989907
3TNIK4.19993233
4EPHB23.53711789
5STK393.08163916
6EPHA32.83713704
7BUB12.62388690
8SGK22.57297552
9CASK2.56415960
10WNK42.54731514
11STK102.52443418
12LATS12.48982530
13DDR22.43079452
14PNCK2.40600863
15TSSK62.25867176
16BRAF2.24845213
17DMPK2.23850324
18PDGFRA2.15480098
19EIF2AK32.10002878
20LATS21.99207952
21TRIB31.89429609
22TTK1.84524504
23FER1.82908908
24EIF2AK11.79682893
25SGK4941.77846118
26SGK2231.77846118
27SGK31.71785254
28TTN1.65178072
29MAP3K121.62725473
30PRPF4B1.61339601
31EEF2K1.60084009
32TGFBR21.58227200
33TIE11.56307647
34WEE11.56240990
35DYRK31.54221629
36PTK61.42314932
37EIF2AK21.40451898
38SCYL21.36729577
39FGFR21.36201745
40NTRK21.34220932
41TAOK21.32699972
42NEK21.22674323
43TRPM71.21337729
44NTRK31.21146007
45SIK31.18235703
46SIK11.11608897
47NME21.08308818
48CHEK21.07095273
49MOS1.06830115
50PTK2B1.06367240
51PKN21.03987176
52ERBB41.02836424
53WNK11.01863024
54MAP3K31.01063200
55AKT20.99208017
56PAK30.97426222
57ERN10.96888545
58PRKCI0.96355851
59FGFR10.95034853
60PAK20.93196041
61MAP3K10.92180658
62LRRK20.90859921
63DYRK1B0.90729402
64ROCK10.90472503
65MELK0.89152851
66RPS6KA40.87900395
67PRKD30.87320949
68MST1R0.87113450
69GRK70.87017859
70STK240.86549419
71BRSK20.85333384
72BRD40.83169897
73MAPKAPK30.82288627
74PIK3CG0.80132694
75NTRK10.80023881
76FGFR30.78867555
77CCNB10.78520334
78PTK20.78047542
79MAP3K110.77281802
80PRKCH0.76906468
81MAP2K10.76883513
82FGFR40.76790104
83PRKD20.76625150
84MAP3K140.75497800
85MUSK0.75202773
86MAPK70.72821298
87MAPK130.71244231
88PDGFRB0.69883279
89PRKCE0.69376050
90MKNK20.69256740
91CDK30.68798609
92PRKD10.68547819
93BMPR20.68282778
94CLK10.66544732
95MYLK0.66159415
96BMX0.66017310
97TGFBR10.63945549
98PLK10.63275487
99ERBB30.62510549
100MAP3K80.61855549
101MAP3K20.61214936
102TAOK30.60161667
103CDC42BPA0.58751059
104DAPK20.58586725
105ICK0.58288067
106NLK0.57974755
107PAK40.57019046
108RPS6KB20.56334157
109NUAK10.56263976
110SRC0.53229812
111TRIM280.52497948
112STK38L0.52379581
113FRK0.52004734
114ROCK20.50683900
115PLK40.50181954
116GRK50.50073091
117PAK60.49688685
118PBK0.49098195
119GRK10.48579590
120ZAK0.48406357
121ADRBK10.48367090
122MARK10.47963787
123MAPKAPK50.47617853
124PRKCG0.47585173
125NEK90.47263522
126IRAK10.46907570
127EPHA20.45720829
128AKT10.45557594
129CHUK0.45474493
130IKBKB0.45253985
131STK380.45074039
132SGK10.44689634
133MKNK10.43744240
134JAK10.42868453
135YES10.42475755
136CDK120.42169258
137LIMK10.41583497
138BRSK10.41512734
139BMPR1B0.40826157
140CDC70.40588265
141AURKB0.40261064
142ILK0.40260737
143PIM20.40007950
144CAMK2A0.39844923
145RIPK10.38388323
146MAPK150.38214473
147CHEK10.36570420
148RPS6KB10.36332190
149MAPKAPK20.35969666
150PLK20.34734427
151ABL20.34637602
152CDK80.34062701
153MET0.33450737
154CDK90.33388886
155EPHA40.33377319
156CAMKK20.33076460
157TAF10.32841990
158CAMK40.32782663
159PRKG10.32520220
160NEK10.30501788
161INSR0.30500401
162ERBB20.30426018
163PLK30.29505286
164MTOR0.29190217
165CDK70.29026524
166PRKG20.28358429
167STK30.28333104
168NEK60.28321398
169ATR0.26108935
170CSF1R0.25695121

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.41623934
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.91471155
3ECM-receptor interaction_Homo sapiens_hsa045123.54771911
4Non-homologous end-joining_Homo sapiens_hsa034503.34416886
5Basal transcription factors_Homo sapiens_hsa030223.00359036
6Fatty acid biosynthesis_Homo sapiens_hsa000612.63044930
7Bladder cancer_Homo sapiens_hsa052192.32980567
8Focal adhesion_Homo sapiens_hsa045102.24908325
9Cell cycle_Homo sapiens_hsa041102.16054896
10* Basal cell carcinoma_Homo sapiens_hsa052172.09334724
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96884831
12Amoebiasis_Homo sapiens_hsa051461.93161478
13Nucleotide excision repair_Homo sapiens_hsa034201.90915274
14One carbon pool by folate_Homo sapiens_hsa006701.90375496
15RNA degradation_Homo sapiens_hsa030181.87401672
16Spliceosome_Homo sapiens_hsa030401.86392734
17Protein digestion and absorption_Homo sapiens_hsa049741.84675001
18Dilated cardiomyopathy_Homo sapiens_hsa054141.83416229
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83371495
20Axon guidance_Homo sapiens_hsa043601.80594130
21RNA transport_Homo sapiens_hsa030131.80260759
22* Proteoglycans in cancer_Homo sapiens_hsa052051.77899646
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.76619720
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73636603
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70094115
26Malaria_Homo sapiens_hsa051441.68965362
27* Hippo signaling pathway_Homo sapiens_hsa043901.68476399
28* Wnt signaling pathway_Homo sapiens_hsa043101.58875701
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57066821
30Melanoma_Homo sapiens_hsa052181.50167399
31* Hedgehog signaling pathway_Homo sapiens_hsa043401.49964721
32TGF-beta signaling pathway_Homo sapiens_hsa043501.45891533
33mRNA surveillance pathway_Homo sapiens_hsa030151.45128065
34Homologous recombination_Homo sapiens_hsa034401.44655600
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37742895
36MicroRNAs in cancer_Homo sapiens_hsa052061.37457652
37Glioma_Homo sapiens_hsa052141.35412199
38* Melanogenesis_Homo sapiens_hsa049161.33236439
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32434313
40Endometrial cancer_Homo sapiens_hsa052131.25781766
41Ribosome_Homo sapiens_hsa030101.24918928
42Adherens junction_Homo sapiens_hsa045201.23385897
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18382114
44Chronic myeloid leukemia_Homo sapiens_hsa052201.16181562
45* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13649729
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13165342
47ErbB signaling pathway_Homo sapiens_hsa040121.13096019
48Small cell lung cancer_Homo sapiens_hsa052221.11434388
49Nicotine addiction_Homo sapiens_hsa050331.11139763
50Sulfur metabolism_Homo sapiens_hsa009201.08601656
51Rap1 signaling pathway_Homo sapiens_hsa040151.07667374
52B cell receptor signaling pathway_Homo sapiens_hsa046621.07173004
53Renin secretion_Homo sapiens_hsa049241.06488928
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05754457
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.05353683
56DNA replication_Homo sapiens_hsa030301.05263885
57Renal cell carcinoma_Homo sapiens_hsa052111.04733356
58Prostate cancer_Homo sapiens_hsa052151.04385176
59Herpes simplex infection_Homo sapiens_hsa051681.01403510
60Fanconi anemia pathway_Homo sapiens_hsa034601.00673367
61GnRH signaling pathway_Homo sapiens_hsa049121.00556521
62Phototransduction_Homo sapiens_hsa047440.99046635
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98794866
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97731972
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97120112
66Circadian entrainment_Homo sapiens_hsa047130.95860217
67Acute myeloid leukemia_Homo sapiens_hsa052210.95715137
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95289664
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.94815216
70Pancreatic cancer_Homo sapiens_hsa052120.94720572
71Colorectal cancer_Homo sapiens_hsa052100.94069710
72Epstein-Barr virus infection_Homo sapiens_hsa051690.93598487
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92653562
74Olfactory transduction_Homo sapiens_hsa047400.92228839
75* Pathways in cancer_Homo sapiens_hsa052000.91957592
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91843549
77Long-term depression_Homo sapiens_hsa047300.90142327
78p53 signaling pathway_Homo sapiens_hsa041150.87633719
79Serotonergic synapse_Homo sapiens_hsa047260.87419969
80Estrogen signaling pathway_Homo sapiens_hsa049150.87407855
81MAPK signaling pathway_Homo sapiens_hsa040100.85914453
82Oxytocin signaling pathway_Homo sapiens_hsa049210.85434144
83Glutamatergic synapse_Homo sapiens_hsa047240.84786849
84Morphine addiction_Homo sapiens_hsa050320.83279251
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.82433228
86Cholinergic synapse_Homo sapiens_hsa047250.82043045
87Sphingolipid metabolism_Homo sapiens_hsa006000.81265372
88Thyroid cancer_Homo sapiens_hsa052160.80633268
89Hematopoietic cell lineage_Homo sapiens_hsa046400.80432942
90Taste transduction_Homo sapiens_hsa047420.80118994
91Pyrimidine metabolism_Homo sapiens_hsa002400.78634725
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78613454
93Cocaine addiction_Homo sapiens_hsa050300.77814503
94Toxoplasmosis_Homo sapiens_hsa051450.77641679
95Non-small cell lung cancer_Homo sapiens_hsa052230.76837711
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76328171
97Salivary secretion_Homo sapiens_hsa049700.76265045
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75493137
99* HTLV-I infection_Homo sapiens_hsa051660.74411072
100Endocytosis_Homo sapiens_hsa041440.74190843
101Circadian rhythm_Homo sapiens_hsa047100.73848265
102RNA polymerase_Homo sapiens_hsa030200.72857192
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72099512
104Mismatch repair_Homo sapiens_hsa034300.70831288
105Calcium signaling pathway_Homo sapiens_hsa040200.70377074
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70297767
107TNF signaling pathway_Homo sapiens_hsa046680.69964907
108Ras signaling pathway_Homo sapiens_hsa040140.69919788
109Proteasome_Homo sapiens_hsa030500.69324723
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68667666
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.67866743
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67679565
113Gap junction_Homo sapiens_hsa045400.66063433
114Long-term potentiation_Homo sapiens_hsa047200.65358438
115Ovarian steroidogenesis_Homo sapiens_hsa049130.64525594
116Oocyte meiosis_Homo sapiens_hsa041140.63651120
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63103106
118cAMP signaling pathway_Homo sapiens_hsa040240.62956616
119Choline metabolism in cancer_Homo sapiens_hsa052310.62528772
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.62388394
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.61581294
122Platelet activation_Homo sapiens_hsa046110.61155744
123Phagosome_Homo sapiens_hsa041450.60538791
124FoxO signaling pathway_Homo sapiens_hsa040680.60310421
125Inositol phosphate metabolism_Homo sapiens_hsa005620.59612827
126Shigellosis_Homo sapiens_hsa051310.59478082
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59276140
128GABAergic synapse_Homo sapiens_hsa047270.58829020
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58746473
130Insulin secretion_Homo sapiens_hsa049110.58358091
131Tight junction_Homo sapiens_hsa045300.58208494
132Viral carcinogenesis_Homo sapiens_hsa052030.57691432
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57648634
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56645120
135Measles_Homo sapiens_hsa051620.56455962
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55737846
137Osteoclast differentiation_Homo sapiens_hsa043800.53863954
138mTOR signaling pathway_Homo sapiens_hsa041500.53047814
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52955942
140Leishmaniasis_Homo sapiens_hsa051400.51908262
141Apoptosis_Homo sapiens_hsa042100.51551268
142HIF-1 signaling pathway_Homo sapiens_hsa040660.51275105
143Viral myocarditis_Homo sapiens_hsa054160.50249789
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49289186
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.46799500
146Purine metabolism_Homo sapiens_hsa002300.44291894
147VEGF signaling pathway_Homo sapiens_hsa043700.43387708
148Selenocompound metabolism_Homo sapiens_hsa004500.41769335
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41221951
150N-Glycan biosynthesis_Homo sapiens_hsa005100.40697251
151African trypanosomiasis_Homo sapiens_hsa051430.36695021
152Influenza A_Homo sapiens_hsa051640.36061296
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.35677606

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