WNT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)7.02897074
2collagen fibril organization (GO:0030199)6.51022739
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.32912652
4regulation of apoptotic cell clearance (GO:2000425)6.09195356
5complement activation, alternative pathway (GO:0006957)5.98587091
6protein heterotrimerization (GO:0070208)5.40108877
7extracellular matrix assembly (GO:0085029)5.32491591
8muscle filament sliding (GO:0030049)5.19636732
9actin-myosin filament sliding (GO:0033275)5.19636732
10cell migration involved in heart development (GO:0060973)5.14365145
11regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)5.11425638
12mesenchymal-epithelial cell signaling (GO:0060638)5.03320923
13cardiac myofibril assembly (GO:0055003)4.92640078
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.91179995
15negative regulation of chondrocyte differentiation (GO:0032331)4.90167499
16skin morphogenesis (GO:0043589)4.86874342
17type B pancreatic cell proliferation (GO:0044342)4.86585503
18extracellular fibril organization (GO:0043206)4.86334593
19opsonization (GO:0008228)4.79348677
20sequestering of extracellular ligand from receptor (GO:0035581)4.43528354
21ATP synthesis coupled proton transport (GO:0015986)4.41048161
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41048161
23actin-mediated cell contraction (GO:0070252)4.38393689
24regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.37851661
25dermatan sulfate biosynthetic process (GO:0030208)4.37505757
26pericardium development (GO:0060039)4.26972922
27keratan sulfate catabolic process (GO:0042340)4.25365047
28cardiac muscle contraction (GO:0060048)4.21656280
29lung vasculature development (GO:0060426)4.20313375
30blood vessel maturation (GO:0001955)4.19178339
31dermatan sulfate metabolic process (GO:0030205)4.16744628
32regulation of complement activation (GO:0030449)4.15957200
33metanephric mesenchyme development (GO:0072075)4.12133185
34* cardiac muscle tissue morphogenesis (GO:0055008)4.11998912
35regulation of protein activation cascade (GO:2000257)4.09019468
36cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.99254705
37negative regulation of cartilage development (GO:0061037)3.95813646
38lung lobe morphogenesis (GO:0060463)3.95690263
39tooth mineralization (GO:0034505)3.93513364
40kidney mesenchyme development (GO:0072074)3.91877084
41fibril organization (GO:0097435)3.91301881
42cardiac muscle hypertrophy (GO:0003300)3.89771791
43regulation of cardioblast differentiation (GO:0051890)3.88496460
44lipoxygenase pathway (GO:0019372)3.87516250
45myofibril assembly (GO:0030239)3.77735313
46collagen metabolic process (GO:0032963)3.75246375
47* muscle tissue morphogenesis (GO:0060415)3.71300137
48heart process (GO:0003015)3.69707989
49heart contraction (GO:0060047)3.69707989
50outflow tract septum morphogenesis (GO:0003148)3.68712510
51striated muscle hypertrophy (GO:0014897)3.67801417
52extracellular matrix disassembly (GO:0022617)3.62803981
53prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.61180697
54complement activation (GO:0006956)3.59561668
55regulation of integrin activation (GO:0033623)3.59206693
56adhesion of symbiont to host cell (GO:0044650)3.58105073
57virion attachment to host cell (GO:0019062)3.58105073
58collagen catabolic process (GO:0030574)3.57726750
59negative regulation of smooth muscle cell migration (GO:0014912)3.56122731
60positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.55409129
61chondroitin sulfate catabolic process (GO:0030207)3.54412590
62regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.54098793
63muscle hypertrophy (GO:0014896)3.53845497
64protein carboxylation (GO:0018214)3.51910421
65peptidyl-glutamic acid carboxylation (GO:0017187)3.51910421
66regulation of cardiac muscle cell differentiation (GO:2000725)3.51609564
67sarcomere organization (GO:0045214)3.50218826
68negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.48919084
69ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.48791421
70multicellular organismal macromolecule metabolic process (GO:0044259)3.48742109
71regulation of transforming growth factor beta2 production (GO:0032909)3.39814674
72glomerular basement membrane development (GO:0032836)3.39154045
73regulation of cardiac muscle hypertrophy (GO:0010611)3.37951212
74apoptotic cell clearance (GO:0043277)3.35892596
75smooth muscle tissue development (GO:0048745)3.35385884
76negative regulation of nitric oxide biosynthetic process (GO:0045019)3.35031633
77branching involved in prostate gland morphogenesis (GO:0060442)3.34262177
78vascular endothelial growth factor signaling pathway (GO:0038084)3.33834971
79multicellular organismal metabolic process (GO:0044236)3.33401235
80positive regulation of cardiac muscle cell differentiation (GO:2000727)3.31340419
81multicellular organismal catabolic process (GO:0044243)3.26765109
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24750379
83actin filament-based movement (GO:0030048)3.23613025
84regulation of muscle hypertrophy (GO:0014743)3.23473246
85trabecula formation (GO:0060343)3.21597129
86* positive regulation of cardiac muscle tissue development (GO:0055025)3.21479416
87extracellular matrix organization (GO:0030198)3.19106776
88long-chain fatty acid biosynthetic process (GO:0042759)3.18504261
89extracellular structure organization (GO:0043062)3.17943903
90positive regulation of endothelial cell apoptotic process (GO:2000353)3.16388366
91endothelial cell chemotaxis (GO:0035767)3.12814914
92endocardial cushion development (GO:0003197)3.12424978
93regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.12376935
94endodermal cell differentiation (GO:0035987)3.12174170
95cell proliferation involved in metanephros development (GO:0072203)3.11987068
96protein localization to cell surface (GO:0034394)3.10802732
97peptide cross-linking (GO:0018149)3.07393209
98striated muscle contraction (GO:0006941)3.00354898
99insulin-like growth factor receptor signaling pathway (GO:0048009)2.99331108
100respiratory electron transport chain (GO:0022904)2.98879567
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.98557950
102chondrocyte development (GO:0002063)2.98554674
103basement membrane organization (GO:0071711)2.98110629
104middle ear morphogenesis (GO:0042474)2.95516529
105negative regulation of BMP signaling pathway (GO:0030514)2.95515005
106embryonic cranial skeleton morphogenesis (GO:0048701)2.94917686
107negative regulation of complement activation (GO:0045916)2.93558169
108adhesion of symbiont to host (GO:0044406)2.93073746
109wound healing, spreading of epidermal cells (GO:0035313)2.92871047
110cell proliferation involved in kidney development (GO:0072111)2.92614907
111complement activation, classical pathway (GO:0006958)2.91994769
112regulation of the force of heart contraction (GO:0002026)2.89798120
113electron transport chain (GO:0022900)2.89199064
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.88082673
115axon extension involved in axon guidance (GO:0048846)2.88082673
116negative regulation of fibrinolysis (GO:0051918)2.87670278
117cellular response to amino acid stimulus (GO:0071230)2.87527623
118regulation of integrin-mediated signaling pathway (GO:2001044)2.87426354
119negative regulation of cardiac muscle tissue growth (GO:0055022)2.86583631
120negative regulation of heart growth (GO:0061117)2.86583631
121embryonic skeletal joint morphogenesis (GO:0060272)2.86176282
122citrulline metabolic process (GO:0000052)2.85835354
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85533901
124L-phenylalanine catabolic process (GO:0006559)2.85533901
125regulation of chondrocyte differentiation (GO:0032330)2.84858166
126actomyosin structure organization (GO:0031032)2.84716100
127citrulline biosynthetic process (GO:0019240)2.83554445
128ATP biosynthetic process (GO:0006754)2.83267131
129surfactant homeostasis (GO:0043129)2.83258687
130regulation of cardiac muscle cell apoptotic process (GO:0010665)2.82775396
131regulation of fibrinolysis (GO:0051917)2.82699809
132venous blood vessel morphogenesis (GO:0048845)2.82321523
133negative regulation of striated muscle cell apoptotic process (GO:0010664)2.82155605
134regulation of cartilage development (GO:0061035)2.81982518
135negative regulation of cardiac muscle tissue development (GO:0055026)2.79603569
136face morphogenesis (GO:0060325)2.78675911
137* positive regulation of cardiac muscle cell proliferation (GO:0060045)2.78459152
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.78230854
139protein activation cascade (GO:0072376)2.78147632
140embryonic forelimb morphogenesis (GO:0035115)2.77471119
141relaxation of smooth muscle (GO:0044557)2.76466332
142hyaluronan catabolic process (GO:0030214)2.76014523
143regulation of striated muscle cell apoptotic process (GO:0010662)2.75736713
144cell differentiation involved in metanephros development (GO:0072202)2.75619196
145* positive regulation of cardiac muscle tissue growth (GO:0055023)2.75122816
146glyoxylate metabolic process (GO:0046487)2.74745542
147cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74634359
148negative regulation of fatty acid transport (GO:2000192)2.74022387
149regulation of humoral immune response (GO:0002920)2.72021954
150positive regulation of epithelial to mesenchymal transition (GO:0010718)2.71761480
151mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71348542
152mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71348542
153regulation of relaxation of muscle (GO:1901077)2.71140599
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.70779191
155positive regulation of fibroblast migration (GO:0010763)2.70058617
156regulation of smooth muscle cell migration (GO:0014910)2.69337643
157regulation of extracellular matrix disassembly (GO:0010715)2.67032716
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.66497260
159L-phenylalanine metabolic process (GO:0006558)2.66497260
160oxidative phosphorylation (GO:0006119)2.66442875
161cardiac muscle cell development (GO:0055013)2.66129616
162extracellular negative regulation of signal transduction (GO:1900116)2.65064189
163extracellular regulation of signal transduction (GO:1900115)2.65064189
164positive regulation of muscle hypertrophy (GO:0014742)2.64535392
165positive regulation of cardiac muscle hypertrophy (GO:0010613)2.64535392
166regulation of plasminogen activation (GO:0010755)2.64030643
167planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63768539
168mesenchymal cell proliferation (GO:0010463)2.63701321
169arginine catabolic process (GO:0006527)2.60884235
170positive regulation of synapse maturation (GO:0090129)2.58327387
171positive regulation of cellular response to oxidative stress (GO:1900409)2.56808895
172positive regulation of response to oxidative stress (GO:1902884)2.56808895
173regulation of macrophage chemotaxis (GO:0010758)2.53422460
174mesenchyme morphogenesis (GO:0072132)2.51991045
175* positive regulation of heart growth (GO:0060421)2.50450660
176* regulation of cardiac muscle tissue development (GO:0055024)2.50194458
177negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.50160355
178regulation of amyloid precursor protein catabolic process (GO:1902991)2.47251918
179membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46905383
180cardiac cell development (GO:0055006)2.46365345
181cardiac muscle adaptation (GO:0014887)2.45662572
182cardiac muscle hypertrophy in response to stress (GO:0014898)2.45662572
183muscle hypertrophy in response to stress (GO:0003299)2.45662572
184vocalization behavior (GO:0071625)2.44935439
185regulation of dendritic spine morphogenesis (GO:0061001)2.42438592
186regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.40650277
187adult heart development (GO:0007512)2.40302571
188* regulation of cardiac muscle tissue growth (GO:0055021)2.39011244
189mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37679795
190mannose metabolic process (GO:0006013)2.37340786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78628779
2GBX2_23144817_ChIP-Seq_PC3_Human3.44598464
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.19524831
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19099237
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.08915501
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.05509236
7EZH2_22144423_ChIP-Seq_EOC_Human2.90362518
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.81540536
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76240670
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69281652
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61795149
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.51025166
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48189415
14BRD4_25478319_ChIP-Seq_HGPS_Human2.44955532
15CJUN_26792858_Chip-Seq_BT549_Human2.41424931
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.40766976
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33758175
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.30656042
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.29948980
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.23870367
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23146998
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23146998
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22090358
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22070108
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11743183
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.10248494
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05679373
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00290329
29JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00071349
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.91940534
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91564178
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.84354906
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.83795822
34TP53_18474530_ChIP-ChIP_U2OS_Human1.78930735
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76697758
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.76214686
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74959118
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74411909
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73670362
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68651310
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66688088
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.64449414
43* BCAT_22108803_ChIP-Seq_LS180_Human1.63583074
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60972463
45SMAD4_21799915_ChIP-Seq_A2780_Human1.60871778
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60155357
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59320926
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58299221
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53801437
50* ISL1_27105846_Chip-Seq_CPCs_Mouse1.53350458
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52648694
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52464105
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52464105
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51629133
55* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50600246
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.49908402
57* ERG_21242973_ChIP-ChIP_JURKAT_Human1.48784830
58VDR_22108803_ChIP-Seq_LS180_Human1.48448238
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46965785
60P300_19829295_ChIP-Seq_ESCs_Human1.45144201
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43942032
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42324387
63* EZH2_27294783_Chip-Seq_ESCs_Mouse1.40838325
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.37808574
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36440715
66ZNF274_21170338_ChIP-Seq_K562_Hela1.35649765
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34196305
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34133486
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32679566
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.31102122
71AHR_22903824_ChIP-Seq_MCF-7_Human1.31085928
72GATA1_22025678_ChIP-Seq_K562_Human1.30431958
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29157987
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28990565
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28906226
76SA1_22415368_ChIP-Seq_MEFs_Mouse1.28123375
77* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28036925
78SMC1_22415368_ChIP-Seq_MEFs_Mouse1.26090729
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.24845075
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24362613
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24142116
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.23080159
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21769340
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21634445
85TP53_16413492_ChIP-PET_HCT116_Human1.21082598
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.20838164
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.20558595
88DROSHA_22980978_ChIP-Seq_HELA_Human1.17467885
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.16519079
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16496627
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16461106
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15877388
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12652947
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12212546
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11330847
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10966228
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10770705
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10213204
99MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09774827
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08598622
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08553015
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06027629
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05614218
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05440785
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04059805
106* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03811131
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02889595
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02889595
109FUS_26573619_Chip-Seq_HEK293_Human1.02447616
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.02398008
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01789901
112REST_21632747_ChIP-Seq_MESCs_Mouse1.01398265
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.00934909
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.00934909
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00551207
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96296493
117* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95910073
118SOX2_20726797_ChIP-Seq_SW620_Human0.95323084
119CLOCK_20551151_ChIP-Seq_293T_Human0.94723481
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94039488
121SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93826990
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93469081
123AR_19668381_ChIP-Seq_PC3_Human0.93157091
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92417663
125* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92091404
126TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91573675
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91356661
128AR_25329375_ChIP-Seq_VCAP_Human0.91143095
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90809965
130* RING1B_27294783_Chip-Seq_ESCs_Mouse0.90496709
131* TCF4_22108803_ChIP-Seq_LS180_Human0.90367299
132AR_21572438_ChIP-Seq_LNCaP_Human0.89967577
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89672418
134HTT_18923047_ChIP-ChIP_STHdh_Human0.89584417
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.89318182
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88545651
137REST_18959480_ChIP-ChIP_MESCs_Mouse0.88353165
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88191079
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88161125
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87632504
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87069517
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86335896
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85619129
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.85550976
145UBF1/2_26484160_Chip-Seq_HMECs_Human0.84754457
146ELK3_25401928_ChIP-Seq_HUVEC_Human0.84753263
147* TP63_23658742_ChIP-Seq_EP156T_Human0.84569917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001958_emphysema3.83811795
2MP0004510_myositis3.65625793
3MP0003122_maternal_imprinting3.65145382
4MP0008438_abnormal_cutaneous_collagen3.33405483
5MP0000749_muscle_degeneration2.96846593
6MP0002736_abnormal_nociception_after2.86951973
7MP0002837_dystrophic_cardiac_calcinosis2.86332643
8MP0005360_urolithiasis2.78220734
9MP0002108_abnormal_muscle_morphology2.76844869
10MP0005451_abnormal_body_composition2.74079304
11MP0001542_abnormal_bone_strength2.68989724
12MP0004084_abnormal_cardiac_muscle2.65525657
13MP0003880_abnormal_central_pattern2.63208983
14MP0005257_abnormal_intraocular_pressure2.45614020
15MP0004859_abnormal_synaptic_plasticity2.34873671
16MP0010368_abnormal_lymphatic_system2.34626074
17MP0006138_congestive_heart_failure2.28832155
18MP0003705_abnormal_hypodermis_morpholog2.26633792
19MP0005508_abnormal_skeleton_morphology2.21589282
20MP0004036_abnormal_muscle_relaxation2.17886842
21MP0001968_abnormal_touch/_nociception2.16439007
22MP0002972_abnormal_cardiac_muscle2.15308200
23MP0004085_abnormal_heartbeat2.11639379
24MP0002060_abnormal_skin_morphology2.11534222
25MP0002139_abnormal_hepatobiliary_system2.09524009
26MP0000516_abnormal_urinary_system2.02194383
27MP0005367_renal/urinary_system_phenotyp2.02194383
28MP0005503_abnormal_tendon_morphology2.01906775
29MP0004272_abnormal_basement_membrane1.94140256
30MP0000537_abnormal_urethra_morphology1.93254885
31MP0005085_abnormal_gallbladder_physiolo1.92283478
32MP0002127_abnormal_cardiovascular_syste1.89901661
33MP0001243_abnormal_dermal_layer1.83170019
34MP0005330_cardiomyopathy1.77934444
35MP0005620_abnormal_muscle_contractility1.75455628
36MP0003123_paternal_imprinting1.71668204
37MP0005275_abnormal_skin_tensile1.71017342
38MP0008875_abnormal_xenobiotic_pharmacok1.66814520
39MP0004484_altered_response_of1.63658841
40MP0003635_abnormal_synaptic_transmissio1.63639328
41MP0003941_abnormal_skin_development1.61767242
42MP0003121_genomic_imprinting1.61425525
43MP0004215_abnormal_myocardial_fiber1.57454826
44MP0005365_abnormal_bile_salt1.56998751
45MP0003950_abnormal_plasma_membrane1.52590748
46MP0005385_cardiovascular_system_phenoty1.50825007
47MP0001544_abnormal_cardiovascular_syste1.50825007
48MP0000751_myopathy1.49700910
49MP0004087_abnormal_muscle_fiber1.46621853
50MP0008775_abnormal_heart_ventricle1.45775552
51MP0003279_aneurysm1.42190574
52MP0009745_abnormal_behavioral_response1.41133899
53MP0002249_abnormal_larynx_morphology1.38804686
54MP0003828_pulmonary_edema1.35567303
55MP0003385_abnormal_body_wall1.34121444
56MP0002063_abnormal_learning/memory/cond1.33970979
57MP0005390_skeleton_phenotype1.33925902
58MP0009384_cardiac_valve_regurgitation1.33728849
59MP0002254_reproductive_system_inflammat1.33234397
60MP0005248_abnormal_Harderian_gland1.32044605
61MP0009053_abnormal_anal_canal1.31479611
62MP0010630_abnormal_cardiac_muscle1.31311185
63MP0004145_abnormal_muscle_electrophysio1.30800440
64MP0009780_abnormal_chondrocyte_physiolo1.29679446
65MP0004134_abnormal_chest_morphology1.29165603
66MP0003221_abnormal_cardiomyocyte_apopto1.28350983
67MP0005595_abnormal_vascular_smooth1.28107475
68MP0005332_abnormal_amino_acid1.27772944
69MP0005171_absent_coat_pigmentation1.26533435
70MP0003075_altered_response_to1.25925518
71MP0003806_abnormal_nucleotide_metabolis1.24640836
72MP0003567_abnormal_fetal_cardiomyocyte1.22706163
73MP0002735_abnormal_chemical_nociception1.22523719
74MP0003329_amyloid_beta_deposits1.18326597
75MP0000230_abnormal_systemic_arterial1.14992658
76MP0010329_abnormal_lipoprotein_level1.14849055
77MP0002064_seizures1.13945819
78MP0002896_abnormal_bone_mineralization1.12950385
79MP0002115_abnormal_skeleton_extremities1.12532384
80MP0001299_abnormal_eye_distance/1.12439537
81MP0000534_abnormal_ureter_morphology1.09712505
82MP0003091_abnormal_cell_migration1.08617142
83MP0000163_abnormal_cartilage_morphology1.07131129
84MP0000604_amyloidosis1.05808517
85MP0004883_abnormal_blood_vessel1.04651844
86MP0000767_abnormal_smooth_muscle1.01492160
87MP0003137_abnormal_impulse_conducting1.00204418
88MP0002572_abnormal_emotion/affect_behav0.99314151
89MP0000462_abnormal_digestive_system0.96155438
90* MP0003115_abnormal_respiratory_system0.95586327
91MP0005023_abnormal_wound_healing0.93798450
92MP0001501_abnormal_sleep_pattern0.93393694
93MP0002106_abnormal_muscle_physiology0.92119493
94MP0010030_abnormal_orbit_morphology0.92029132
95MP0005623_abnormal_meninges_morphology0.91142558
96MP0000013_abnormal_adipose_tissue0.91024685
97MP0006054_spinal_hemorrhage0.89409801
98MP0002168_other_aberrant_phenotype0.89271384
99MP0001348_abnormal_lacrimal_gland0.88806483
100MP0001879_abnormal_lymphatic_vessel0.85992892
101MP0008004_abnormal_stomach_pH0.85232008
102MP0010352_gastrointestinal_tract_polyps0.84927737
103MP0002909_abnormal_adrenal_gland0.82868085
104MP0003566_abnormal_cell_adhesion0.81867139
105MP0005058_abnormal_lysosome_morphology0.80026757
106MP0003119_abnormal_digestive_system0.79806008
107MP0004233_abnormal_muscle_weight0.79349788
108MP0000733_abnormal_muscle_development0.78826929
109MP0000538_abnormal_urinary_bladder0.78685656
110MP0005369_muscle_phenotype0.78675810
111MP0001529_abnormal_vocalization0.78622885
112MP0002332_abnormal_exercise_endurance0.78232798
113MP0000428_abnormal_craniofacial_morphol0.76781268
114MP0002269_muscular_atrophy0.75833089
115MP0002295_abnormal_pulmonary_circulatio0.75373708
116MP0002932_abnormal_joint_morphology0.75233098
117MP0010386_abnormal_urinary_bladder0.74964058
118MP0000747_muscle_weakness0.74322879
119MP0002128_abnormal_blood_circulation0.74031124
120MP0000266_abnormal_heart_morphology0.73980864
121MP0002109_abnormal_limb_morphology0.73809816
122MP0001440_abnormal_grooming_behavior0.73770236
123MP0000249_abnormal_blood_vessel0.72667286
124MP0004858_abnormal_nervous_system0.72332989
125MP0005164_abnormal_response_to0.71882610
126MP0002933_joint_inflammation0.71393240
127MP0002113_abnormal_skeleton_development0.71002552
128MP0005166_decreased_susceptibility_to0.70551442
129* MP0001175_abnormal_lung_morphology0.70207620
130MP0000762_abnormal_tongue_morphology0.69754552
131* MP0002282_abnormal_trachea_morphology0.69626526
132MP0003448_altered_tumor_morphology0.69477612
133MP0003937_abnormal_limbs/digits/tail_de0.68605667
134MP0005165_increased_susceptibility_to0.68524156
135MP0000049_abnormal_middle_ear0.67736574
136MP0009250_abnormal_appendicular_skeleto0.67426476
137MP0000432_abnormal_head_morphology0.67356346
138MP0003942_abnormal_urinary_system0.66458820
139* MP0002133_abnormal_respiratory_system0.66199024
140* MP0005388_respiratory_system_phenotype0.66199024
141MP0001533_abnormal_skeleton_physiology0.65535532
142* MP0001614_abnormal_blood_vessel0.64835651
143MP0000003_abnormal_adipose_tissue0.62504714
144MP0002998_abnormal_bone_remodeling0.60797916
145MP0000759_abnormal_skeletal_muscle0.60131571
146MP0003795_abnormal_bone_structure0.57144642
147MP0001177_atelectasis0.56471674
148MP0003300_gastrointestinal_ulcer0.56296632
149MP0002114_abnormal_axial_skeleton0.55847937
150MP0005197_abnormal_uvea_morphology0.55330154
151MP0002233_abnormal_nose_morphology0.53191458
152MP0002116_abnormal_craniofacial_bone0.52969417
153MP0003935_abnormal_craniofacial_develop0.51230310
154MP0000613_abnormal_salivary_gland0.50591826
155MP0010771_integument_phenotype0.50475400
156MP0000750_abnormal_muscle_regeneration0.49523399
157MP0003045_fibrosis0.49328696
158MP0005076_abnormal_cell_differentiation0.47522062
159MP0002925_abnormal_cardiovascular_devel0.46174224
160MP0003755_abnormal_palate_morphology0.46019546

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.81270700
2Systemic lupus erythematosus (HP:0002725)6.02461506
3Soft skin (HP:0000977)5.92061124
4Complement deficiency (HP:0004431)5.01442719
5Atrophic scars (HP:0001075)4.83930251
6Dilatation of the ascending aorta (HP:0005111)4.66256530
7Bladder diverticulum (HP:0000015)4.66141388
8Abnormality of complement system (HP:0005339)4.60217685
9Deep venous thrombosis (HP:0002625)4.47170193
10Mitral valve prolapse (HP:0001634)4.20313544
11Fragile skin (HP:0001030)4.16234977
12Neonatal short-limb short stature (HP:0008921)4.05851443
13Follicular hyperkeratosis (HP:0007502)3.99542514
14Abnormality of dentin (HP:0010299)3.88824697
15Ankle contracture (HP:0006466)3.88117566
16Glomerulonephritis (HP:0000099)3.84842199
17Exercise-induced muscle cramps (HP:0003710)3.84740011
18Sudden death (HP:0001699)3.68821923
19Congenital malformation of the right heart (HP:0011723)3.66809146
20Double outlet right ventricle (HP:0001719)3.66809146
21Prolonged partial thromboplastin time (HP:0003645)3.59489969
22Genu recurvatum (HP:0002816)3.55952532
23Patent foramen ovale (HP:0001655)3.50156174
24Shallow orbits (HP:0000586)3.46370940
25Cerebral aneurysm (HP:0004944)3.45482556
26Wormian bones (HP:0002645)3.44637764
27Abnormal gallbladder physiology (HP:0012438)3.38634603
28Cholecystitis (HP:0001082)3.38634603
29Hyperextensible skin (HP:0000974)3.29998819
30Blue sclerae (HP:0000592)3.28206068
31Hyperventilation (HP:0002883)3.20616038
32Overgrowth (HP:0001548)3.20261106
33Bowel diverticulosis (HP:0005222)3.12475870
34Striae distensae (HP:0001065)3.08059381
35Aortic dissection (HP:0002647)3.06920349
36Protrusio acetabuli (HP:0003179)3.03979559
37Acute necrotizing encephalopathy (HP:0006965)3.02667063
38Lipoatrophy (HP:0100578)2.99633904
39Decreased circulating renin level (HP:0003351)2.98748786
40Wide anterior fontanel (HP:0000260)2.95969412
41Calf muscle hypertrophy (HP:0008981)2.94014602
42Joint laxity (HP:0001388)2.91893591
43Biconcave vertebral bodies (HP:0004586)2.91049594
44Aortic aneurysm (HP:0004942)2.86654795
45Atrial fibrillation (HP:0005110)2.83374692
46Slender build (HP:0001533)2.82918738
47Aneurysm (HP:0002617)2.82693153
48Abnormal mitochondria in muscle tissue (HP:0008316)2.81269302
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.81203672
50Osteolytic defects of the hand bones (HP:0009699)2.81203672
51Spinal rigidity (HP:0003306)2.74853453
52Mitral regurgitation (HP:0001653)2.74590898
53Muscle hypertrophy of the lower extremities (HP:0008968)2.74401181
54Focal motor seizures (HP:0011153)2.74239741
55Aortic regurgitation (HP:0001659)2.72432648
56Primary atrial arrhythmia (HP:0001692)2.68038858
57Acute encephalopathy (HP:0006846)2.64467997
58Abnormal delivery (HP:0001787)2.63702106
59Wrist flexion contracture (HP:0001239)2.63177115
60Hepatoblastoma (HP:0002884)2.57807655
61Coronal craniosynostosis (HP:0004440)2.56882094
62Ectopia lentis (HP:0001083)2.56864838
63Abnormality of the common coagulation pathway (HP:0010990)2.56567018
64Hypobetalipoproteinemia (HP:0003563)2.55354585
65Supraventricular tachycardia (HP:0004755)2.53866172
66Exercise-induced myalgia (HP:0003738)2.51482510
67Broad metatarsal (HP:0001783)2.50739101
68Malnutrition (HP:0004395)2.48889886
69Supraventricular arrhythmia (HP:0005115)2.47677229
70Hydroureter (HP:0000072)2.46606328
71Hypoplastic left heart (HP:0004383)2.45348300
72Elbow flexion contracture (HP:0002987)2.43109700
73Progressive macrocephaly (HP:0004481)2.42207872
74Joint stiffness (HP:0001387)2.41909876
75Hypoplasia of the iris (HP:0007676)2.41400966
76Abnormality of the acetabulum (HP:0003170)2.40613383
77J-shaped sella turcica (HP:0002680)2.38270013
78Mild short stature (HP:0003502)2.37925733
79Nephritis (HP:0000123)2.36757400
80Aortic valve stenosis (HP:0001650)2.35342777
81Camptodactyly of toe (HP:0001836)2.34981471
82Subacute progressive viral hepatitis (HP:0006572)2.33939678
83Disproportionate tall stature (HP:0001519)2.32699903
84Cerebral edema (HP:0002181)2.32639189
85Mitral stenosis (HP:0001718)2.32304176
86Increased corneal curvature (HP:0100692)2.32149536
87Keratoconus (HP:0000563)2.32149536
88Abnormality of the fetal cardiovascular system (HP:0010948)2.28693316
89Abnormal umbilical cord blood vessels (HP:0011403)2.28693316
90Single umbilical artery (HP:0001195)2.28693316
91Thin bony cortex (HP:0002753)2.28492643
92Vertebral compression fractures (HP:0002953)2.27291770
93Syncope (HP:0001279)2.25929572
94Cervical subluxation (HP:0003308)2.25003206
95Limited hip movement (HP:0008800)2.24808288
96Morphological abnormality of the middle ear (HP:0008609)2.23530747
97Spondylolisthesis (HP:0003302)2.23199991
98Right ventricular cardiomyopathy (HP:0011663)2.22806419
99Neuroendocrine neoplasm (HP:0100634)2.21458978
100Breech presentation (HP:0001623)2.18145449
101Cerebral inclusion bodies (HP:0100314)2.17611540
102Asymmetric septal hypertrophy (HP:0001670)2.17534437
103Round ear (HP:0100830)2.16831421
104Osteoarthritis (HP:0002758)2.15465811
105Centrally nucleated skeletal muscle fibers (HP:0003687)2.13845622
106Broad ribs (HP:0000885)2.12260490
107Hypoventilation (HP:0002791)2.11188087
108Deviation of the hallux (HP:0010051)2.10819540
109Infantile muscular hypotonia (HP:0008947)2.10689912
110Abnormality of the calf musculature (HP:0001430)2.10138281
111Increased variability in muscle fiber diameter (HP:0003557)2.09108454
112Abnormal pancreas size (HP:0012094)2.08076996
113Hip contracture (HP:0003273)2.06775277
114Esophageal neoplasm (HP:0100751)2.06214006
115Neoplasm of head and neck (HP:0012288)2.06214006
116Delusions (HP:0000746)2.05833692
117Increased connective tissue (HP:0009025)2.05236242
118Mitochondrial inheritance (HP:0001427)2.03884886
119Nonimmune hydrops fetalis (HP:0001790)2.03427465
120Hepatocellular carcinoma (HP:0001402)2.02388081
121Thoracolumbar scoliosis (HP:0002944)2.01786146
122Atrioventricular block (HP:0001678)2.01519342
123Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00901294
124Knee flexion contracture (HP:0006380)2.00890907
125Peritonitis (HP:0002586)2.00825315
126Conjunctival hamartoma (HP:0100780)2.00484134
127Mildly elevated creatine phosphokinase (HP:0008180)2.00396939
128Abnormality of urine glucose concentration (HP:0011016)2.00032801
129Glycosuria (HP:0003076)2.00032801
130Arterial tortuosity (HP:0005116)1.98766978
131Flat cornea (HP:0007720)1.98628673
132Inguinal hernia (HP:0000023)1.98154674
133Exercise intolerance (HP:0003546)1.97694924
134Rimmed vacuoles (HP:0003805)1.97610275
135Redundant skin (HP:0001582)1.97030076
136Steppage gait (HP:0003376)1.96769700
137Hallux valgus (HP:0001822)1.96398652
138Pheochromocytoma (HP:0002666)1.95813252
139Ovoid vertebral bodies (HP:0003300)1.94254624
140Renovascular hypertension (HP:0100817)1.91961187
141Venous insufficiency (HP:0005293)1.90361851
142Hyporeflexia of lower limbs (HP:0002600)1.89807932
143Delayed closure of the anterior fontanelle (HP:0001476)1.88845020
144Venous abnormality (HP:0002624)1.88724147
145Ragged-red muscle fibers (HP:0003200)1.87272021
146Flexion contracture of toe (HP:0005830)1.86324252
147Joint contractures involving the joints of the feet (HP:0100492)1.86324252
148Mesomelia (HP:0003027)1.86031656
149Increased CSF lactate (HP:0002490)1.85957548
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85701073
151Recurrent gram-negative bacterial infections (HP:0005420)1.85249194
152Ventricular tachycardia (HP:0004756)1.85101503
153Gingival overgrowth (HP:0000212)1.84988345
154Dilated cardiomyopathy (HP:0001644)1.84965010
155Cerebral hemorrhage (HP:0001342)1.84945498
156Emphysema (HP:0002097)1.84210664
157Vascular tortuosity (HP:0004948)1.83662529
158Diastasis recti (HP:0001540)1.82709989
159Delayed cranial suture closure (HP:0000270)1.82389597
160Broad long bones (HP:0005622)1.81536952
161Increased serum pyruvate (HP:0003542)1.81033486
162Abnormality of glycolysis (HP:0004366)1.81033486
163Joint hemorrhage (HP:0005261)1.80718259
164Persistence of primary teeth (HP:0006335)1.80599457
165Protruding ear (HP:0000411)1.80311042
166Osteopenia (HP:0000938)1.79229803
167Arachnodactyly (HP:0001166)1.78291277
168Myoglobinuria (HP:0002913)1.77353792
169Xanthomatosis (HP:0000991)1.77305243
170Long toe (HP:0010511)1.74620110
171Narrow nasal bridge (HP:0000446)1.74118157
172Thin skin (HP:0000963)1.73960727
173EMG: myopathic abnormalities (HP:0003458)1.72779245
174Delayed CNS myelination (HP:0002188)1.72254176
175Pectus carinatum (HP:0000768)1.71870936
176Natal tooth (HP:0000695)1.71746654
177Neurofibrillary tangles (HP:0002185)1.71471483
178Cardiovascular calcification (HP:0011915)1.68936987
179Ventricular arrhythmia (HP:0004308)1.67234865
180Bronchomalacia (HP:0002780)1.66768119
181Hypoplastic heart (HP:0001961)1.65310725
182Atonic seizures (HP:0010819)1.64943373
183Type 1 muscle fiber predominance (HP:0003803)1.64569475
184Hypolipoproteinemia (HP:0010981)1.64333891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.68145082
2MYLK4.60800533
3PDGFRA4.39724794
4LATS13.98956819
5EPHA43.94708111
6DDR23.66099183
7MST1R3.18722637
8RIPK43.02020254
9NEK92.56121540
10AKT32.42884441
11PTK2B2.24519329
12PLK22.11641053
13PKN22.11568700
14NTRK32.11175486
15DAPK22.10627234
16LATS22.05842533
17PDGFRB2.04969708
18ZAK2.01483267
19MAP3K121.88556091
20MAP2K41.87443592
21STK241.81797348
22ARAF1.79104852
23EPHB21.76876857
24MAP3K41.76583179
25KIT1.70800682
26PIK3CA1.65112729
27MAP2K71.62311727
28STK38L1.61482061
29DAPK31.60444079
30MINK11.57048537
31DAPK11.54502315
32BMPR21.46605072
33KSR11.43103486
34PTK21.39724511
35PIK3CG1.36735029
36PRKD21.35966856
37MAP3K91.35247142
38MET1.34538768
39PRPF4B1.28328954
40MAP3K131.26184685
41PBK1.25557620
42LIMK11.24487053
43CASK1.23459608
44MAPK71.13193409
45RAF11.12062775
46ILK1.09936298
47RIPK10.99193595
48GRK50.95337329
49TTN0.92656914
50TRPM70.92440388
51KSR20.92438674
52NTRK10.92342603
53WNK10.92228250
54BCR0.91035354
55TESK10.90905720
56FGR0.90700395
57MARK20.90646619
58JAK10.86461163
59FES0.81609717
60FGFR40.81319476
61BCKDK0.80822707
62GRK60.80754582
63CAMK2A0.80331744
64RPS6KA20.79730228
65TYK20.79265488
66NME10.77958972
67PIM20.76613691
68PAK30.74879712
69GRK10.74130037
70SIK10.71084746
71CDC42BPA0.69306846
72DMPK0.68356462
73MTOR0.65710187
74TRIB30.63142297
75SIK30.62365021
76PRKCH0.62291812
77ABL20.60452165
78GRK70.60419857
79NLK0.60229496
80STK380.60008623
81CAMK2B0.58067253
82FGFR30.57119664
83RPS6KL10.56954561
84RPS6KC10.56954561
85GSK3A0.56596418
86PRKD10.56254356
87PAK40.55845076
88PRKCG0.54151413
89MAP3K70.53818321
90FLT30.53347984
91BRAF0.52957927
92FGFR10.52925000
93CAMK10.52741899
94PAK20.52686279
95RET0.50698244
96PRKCE0.50529281
97ROCK20.50069070
98PRKD30.49842939
99ERN10.48915256
100MAP2K10.47931942
101TGFBR20.47084286
102ABL10.46629185
103ROCK10.45214951
104PRKG10.44824183
105FYN0.44675059
106RPS6KA60.44316337
107BMX0.43853577
108EPHA30.42272397
109TGFBR10.41839461
110MAP3K60.41283558
111ADRBK20.41227043
112CAMK2G0.39726969
113CDK50.39573773
114INSRR0.39081249
115CAMK2D0.38996280
116EPHB10.38303842
117EGFR0.37585745
118MAPK120.37372336
119PRKACA0.36740670
120INSR0.36557791
121PRKCQ0.36475863
122MELK0.36402521
123FER0.36137565
124MOS0.35601839
125ADRBK10.34735748
126MARK30.34685268
127STK30.33782428
128TIE10.33206023
129IGF1R0.32440113
130PNCK0.32104052
131MAPK40.30824584
132CAMKK10.30678943
133CDK80.30411839
134DYRK1A0.30284237
135STK160.30100562
136CAMK1G0.29856501
137PRKCZ0.29597488
138MAP3K110.29088960
139CDK180.28846439
140MAPK10.28505067
141ICK0.28012058
142CDK140.27845195
143PAK10.27783597
144PAK60.27726375
145SRC0.26542330
146MAPKAPK50.25086954
147PRKG20.24181291
148ERBB40.23831761
149MAPKAPK20.23575628
150ERBB30.22392329
151TAF10.20368214
152HIPK20.18965082
153SGK2230.18830399

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.84851751
2Staphylococcus aureus infection_Homo sapiens_hsa051503.56908922
3Cardiac muscle contraction_Homo sapiens_hsa042603.49023542
4Protein digestion and absorption_Homo sapiens_hsa049743.47781097
5Complement and coagulation cascades_Homo sapiens_hsa046103.11745304
6Oxidative phosphorylation_Homo sapiens_hsa001902.98234622
7Parkinsons disease_Homo sapiens_hsa050122.57219519
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.43892076
9* Proteoglycans in cancer_Homo sapiens_hsa052052.37338614
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37107933
11Alzheimers disease_Homo sapiens_hsa050102.33368334
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23266323
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.12485326
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04925466
15Dilated cardiomyopathy_Homo sapiens_hsa054142.01713932
16Melanoma_Homo sapiens_hsa052181.93196990
17Malaria_Homo sapiens_hsa051441.86899689
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83574668
19Nicotine addiction_Homo sapiens_hsa050331.79067895
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.70453549
21Adherens junction_Homo sapiens_hsa045201.69743795
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69004214
23* Hedgehog signaling pathway_Homo sapiens_hsa043401.68166167
24Huntingtons disease_Homo sapiens_hsa050161.63475970
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.60587577
26Circadian entrainment_Homo sapiens_hsa047131.56724164
27Arginine biosynthesis_Homo sapiens_hsa002201.55329935
28Long-term potentiation_Homo sapiens_hsa047201.52127349
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48355031
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.47945474
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47891193
32* Basal cell carcinoma_Homo sapiens_hsa052171.41820856
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40384828
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35434719
35Morphine addiction_Homo sapiens_hsa050321.33804235
36Prostate cancer_Homo sapiens_hsa052151.32207091
37Olfactory transduction_Homo sapiens_hsa047401.31401544
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28977932
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28688045
40Small cell lung cancer_Homo sapiens_hsa052221.26133250
41Serotonergic synapse_Homo sapiens_hsa047261.25241421
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25222541
43* Hippo signaling pathway_Homo sapiens_hsa043901.23175897
44Carbon metabolism_Homo sapiens_hsa012001.22605418
45* Pathways in cancer_Homo sapiens_hsa052001.22264325
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18691963
47Pyruvate metabolism_Homo sapiens_hsa006201.17583262
48Other glycan degradation_Homo sapiens_hsa005111.17235756
49Biosynthesis of amino acids_Homo sapiens_hsa012301.15081491
50Calcium signaling pathway_Homo sapiens_hsa040201.13832798
51Dopaminergic synapse_Homo sapiens_hsa047281.13516426
52Bladder cancer_Homo sapiens_hsa052191.12200609
53Amphetamine addiction_Homo sapiens_hsa050311.09741900
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09479131
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09397184
56Starch and sucrose metabolism_Homo sapiens_hsa005001.08976470
57GABAergic synapse_Homo sapiens_hsa047271.07116379
58Renin-angiotensin system_Homo sapiens_hsa046141.06932816
59Rap1 signaling pathway_Homo sapiens_hsa040151.06715186
60Prion diseases_Homo sapiens_hsa050201.06321852
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06271911
62Renin secretion_Homo sapiens_hsa049241.04260085
63mTOR signaling pathway_Homo sapiens_hsa041501.04056563
64* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03897545
65Oxytocin signaling pathway_Homo sapiens_hsa049211.01986157
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01544631
67Glioma_Homo sapiens_hsa052141.00453772
68Nitrogen metabolism_Homo sapiens_hsa009100.99089545
69MicroRNAs in cancer_Homo sapiens_hsa052060.98704322
70Long-term depression_Homo sapiens_hsa047300.97674266
71Salivary secretion_Homo sapiens_hsa049700.96794873
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96529705
73Propanoate metabolism_Homo sapiens_hsa006400.96394295
74Glutamatergic synapse_Homo sapiens_hsa047240.96002389
75Phenylalanine metabolism_Homo sapiens_hsa003600.95951288
76Arachidonic acid metabolism_Homo sapiens_hsa005900.95127918
77Platelet activation_Homo sapiens_hsa046110.93468272
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.92898749
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.92437720
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91826463
81Gap junction_Homo sapiens_hsa045400.91337139
82Tight junction_Homo sapiens_hsa045300.87714604
83Ras signaling pathway_Homo sapiens_hsa040140.86158810
84Caffeine metabolism_Homo sapiens_hsa002320.85552886
85Tryptophan metabolism_Homo sapiens_hsa003800.84573716
86Synaptic vesicle cycle_Homo sapiens_hsa047210.83621255
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83144684
88Galactose metabolism_Homo sapiens_hsa000520.82727664
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81861413
90Sulfur metabolism_Homo sapiens_hsa009200.79950507
91Endocytosis_Homo sapiens_hsa041440.79434245
92Chronic myeloid leukemia_Homo sapiens_hsa052200.77155618
93Collecting duct acid secretion_Homo sapiens_hsa049660.76185281
94* Wnt signaling pathway_Homo sapiens_hsa043100.76164777
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75345653
96Pertussis_Homo sapiens_hsa051330.75040264
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74183352
98Fatty acid degradation_Homo sapiens_hsa000710.73546154
99Glucagon signaling pathway_Homo sapiens_hsa049220.73155802
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72818978
101Toxoplasmosis_Homo sapiens_hsa051450.72630183
102MAPK signaling pathway_Homo sapiens_hsa040100.71424134
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71069927
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.68990399
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.68716927
106Amoebiasis_Homo sapiens_hsa051460.68673047
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68524698
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66656452
109Butanoate metabolism_Homo sapiens_hsa006500.66095724
110Lysosome_Homo sapiens_hsa041420.65942856
111Renal cell carcinoma_Homo sapiens_hsa052110.65543862
112Chemical carcinogenesis_Homo sapiens_hsa052040.65539021
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65004251
114Fructose and mannose metabolism_Homo sapiens_hsa000510.64434101
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64001176
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63625896
117TGF-beta signaling pathway_Homo sapiens_hsa043500.62280568
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62045366
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61858763
120PPAR signaling pathway_Homo sapiens_hsa033200.60991576
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60299776
122Pancreatic cancer_Homo sapiens_hsa052120.60269768
123Bile secretion_Homo sapiens_hsa049760.59974496
124TNF signaling pathway_Homo sapiens_hsa046680.59790698
125Tyrosine metabolism_Homo sapiens_hsa003500.58920609
126Phagosome_Homo sapiens_hsa041450.58420242
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58168285
128Endometrial cancer_Homo sapiens_hsa052130.58046290
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.57324973
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56693653
131Peroxisome_Homo sapiens_hsa041460.56518143
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56507669
133Choline metabolism in cancer_Homo sapiens_hsa052310.56264825
134Taste transduction_Homo sapiens_hsa047420.54949785
135Cocaine addiction_Homo sapiens_hsa050300.54883951
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54379009
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50902194
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50821055
139ABC transporters_Homo sapiens_hsa020100.50632346
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50470397
141Histidine metabolism_Homo sapiens_hsa003400.49531607
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48958874
143N-Glycan biosynthesis_Homo sapiens_hsa005100.48286122
144Gastric acid secretion_Homo sapiens_hsa049710.48058384
145p53 signaling pathway_Homo sapiens_hsa041150.48005385
146Mineral absorption_Homo sapiens_hsa049780.46073856
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45265103
148Viral myocarditis_Homo sapiens_hsa054160.44869331
149cAMP signaling pathway_Homo sapiens_hsa040240.44644411
150African trypanosomiasis_Homo sapiens_hsa051430.44525785
151Colorectal cancer_Homo sapiens_hsa052100.43226004
152Focal adhesion_Homo sapiens_hsa045100.42186565
153GnRH signaling pathway_Homo sapiens_hsa049120.41830240
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.41622598
155Rheumatoid arthritis_Homo sapiens_hsa053230.41608174
156Axon guidance_Homo sapiens_hsa043600.40946595
157Thyroid hormone synthesis_Homo sapiens_hsa049180.40798910
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.40391205
159FoxO signaling pathway_Homo sapiens_hsa040680.40244378
160Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40098719
161Estrogen signaling pathway_Homo sapiens_hsa049150.39706482
162beta-Alanine metabolism_Homo sapiens_hsa004100.39592583
163Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39428650
164Insulin secretion_Homo sapiens_hsa049110.38652706
165* HTLV-I infection_Homo sapiens_hsa051660.38529459
166Drug metabolism - other enzymes_Homo sapiens_hsa009830.37200288
167Shigellosis_Homo sapiens_hsa051310.36646522
168AMPK signaling pathway_Homo sapiens_hsa041520.36513459
169Ovarian steroidogenesis_Homo sapiens_hsa049130.35810976
170HIF-1 signaling pathway_Homo sapiens_hsa040660.34553937
171* Melanogenesis_Homo sapiens_hsa049160.33722553

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