WNT2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spinal cord association neuron differentiation (GO:0021527)6.26662843
2positive regulation of gastrulation (GO:2000543)5.64385884
3negative regulation of axon extension involved in axon guidance (GO:0048843)5.39532431
4negative regulation of axon guidance (GO:1902668)5.14460881
5regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.42696084
6lateral sprouting from an epithelium (GO:0060601)4.37498323
7positive regulation of cardiac muscle cell differentiation (GO:2000727)4.36954873
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.34447407
9cell proliferation in forebrain (GO:0021846)4.34134688
10regulation of mesoderm development (GO:2000380)4.31849426
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.23253661
12behavioral response to nicotine (GO:0035095)4.20158265
13regulation of non-canonical Wnt signaling pathway (GO:2000050)4.11983667
14detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.11591274
15detection of temperature stimulus involved in sensory perception (GO:0050961)4.11591274
16regulation of collateral sprouting (GO:0048670)4.06968251
17kidney morphogenesis (GO:0060993)4.01250118
18nonmotile primary cilium assembly (GO:0035058)3.95738544
19negative regulation of complement activation (GO:0045916)3.89102624
20positive regulation of catenin import into nucleus (GO:0035413)3.85150185
21detection of temperature stimulus (GO:0016048)3.83092071
22postsynaptic membrane organization (GO:0001941)3.78982153
23regulation of axon guidance (GO:1902667)3.73716797
24regulation of axon extension involved in axon guidance (GO:0048841)3.69993849
25presynaptic membrane assembly (GO:0097105)3.69435543
26* positive regulation of embryonic development (GO:0040019)3.64083643
27cell communication involved in cardiac conduction (GO:0086065)3.61647728
28retinal ganglion cell axon guidance (GO:0031290)3.59086993
29cell differentiation in spinal cord (GO:0021515)3.54960875
30alanine transport (GO:0032328)3.52738581
31negative regulation of cytosolic calcium ion concentration (GO:0051481)3.48962349
32response to pheromone (GO:0019236)3.46312327
33neuron fate determination (GO:0048664)3.41543144
34membrane depolarization during action potential (GO:0086010)3.41480128
35negative regulation of protein activation cascade (GO:2000258)3.40344005
36limb bud formation (GO:0060174)3.39695057
37positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.32710676
38midbrain development (GO:0030901)3.31752532
39epithelial cilium movement (GO:0003351)3.29124281
40negative chemotaxis (GO:0050919)3.28897917
41sodium ion export (GO:0071436)3.27466337
42dorsal/ventral neural tube patterning (GO:0021904)3.27164598
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25861097
44proline transport (GO:0015824)3.24898948
45presynaptic membrane organization (GO:0097090)3.24144420
46regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.19934513
47positive regulation of meiosis (GO:0045836)3.18682087
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18205775
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18029057
50neuronal action potential (GO:0019228)3.16772576
51regulation of cardioblast differentiation (GO:0051890)3.16027234
52synaptic vesicle maturation (GO:0016188)3.15228543
53neuron projection extension involved in neuron projection guidance (GO:1902284)3.10870865
54axon extension involved in axon guidance (GO:0048846)3.10870865
55* hematopoietic stem cell proliferation (GO:0071425)2.99318633
56detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98606877
57cell fate commitment involved in formation of primary germ layer (GO:0060795)2.97851380
58positive regulation of meiotic cell cycle (GO:0051446)2.95359277
59low-density lipoprotein particle clearance (GO:0034383)2.93753564
60cell migration in hindbrain (GO:0021535)2.93289470
61cardiovascular system development (GO:0072358)2.91956436
62somite development (GO:0061053)2.91042470
63cell communication by electrical coupling (GO:0010644)2.90989095
64positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90646607
65negative regulation of axon extension (GO:0030517)2.88192949
66transmission of nerve impulse (GO:0019226)2.87861413
67positive regulation of cardiac muscle hypertrophy (GO:0010613)2.86670073
68positive regulation of muscle hypertrophy (GO:0014742)2.86670073
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.86406209
70protein localization to cilium (GO:0061512)2.85801483
71appendage development (GO:0048736)2.85125072
72limb development (GO:0060173)2.85125072
73positive regulation of fatty acid beta-oxidation (GO:0032000)2.82626587
74plasma membrane repair (GO:0001778)2.82242458
75negative regulation of cell fate specification (GO:0009996)2.81417720
76post-anal tail morphogenesis (GO:0036342)2.79173599
77regulation of ARF protein signal transduction (GO:0032012)2.72322767
78inner ear receptor stereocilium organization (GO:0060122)2.72123195
79myoblast fusion (GO:0007520)2.70490636
80nucleobase catabolic process (GO:0046113)2.68723299
81cerebellar Purkinje cell differentiation (GO:0021702)2.67386626
82cilium movement (GO:0003341)2.65704499
83cilium organization (GO:0044782)2.62156649
84urinary tract smooth muscle contraction (GO:0014848)2.61059802
85photoreceptor cell maintenance (GO:0045494)2.60818548
86cilium assembly (GO:0042384)2.60762793
87regulation of short-term neuronal synaptic plasticity (GO:0048172)2.60751562
88cellular response to prostaglandin stimulus (GO:0071379)2.59727052
89behavioral response to ethanol (GO:0048149)2.59475688
90positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.59457737
91glycerophospholipid catabolic process (GO:0046475)2.59350368
92positive regulation of glycogen metabolic process (GO:0070875)2.58733073
93regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.58366376
94positive regulation of cell fate commitment (GO:0010455)2.57622861
95embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57425520
96activation of protein kinase A activity (GO:0034199)2.56999142
97prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.56481761
98positive regulation of fatty acid oxidation (GO:0046321)2.56198876
99potassium ion export (GO:0071435)2.55186933
100nephron epithelium morphogenesis (GO:0072088)2.55091354
101nephron tubule morphogenesis (GO:0072078)2.55091354
102detection of light stimulus involved in visual perception (GO:0050908)2.54667536
103detection of light stimulus involved in sensory perception (GO:0050962)2.54667536
104carnitine shuttle (GO:0006853)2.53623981
105bone trabecula formation (GO:0060346)2.53303836
106regulation of cardiac muscle cell differentiation (GO:2000725)2.53208312
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.53114713
108negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52355350
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51783249
110cilium morphogenesis (GO:0060271)2.51318865
111pericardium development (GO:0060039)2.50505029
112positive regulation of glycogen biosynthetic process (GO:0045725)2.50485061
113regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.49802485
114neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.49359718
115pyrimidine nucleobase catabolic process (GO:0006208)2.48001849
116cellular potassium ion homeostasis (GO:0030007)2.47817024
117negative regulation of hormone biosynthetic process (GO:0032353)2.47123246
118cellular sodium ion homeostasis (GO:0006883)2.47092773
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47005305
120otic vesicle formation (GO:0030916)2.46934688
121negative regulation of smooth muscle cell migration (GO:0014912)2.46678611
122negative regulation of dendrite morphogenesis (GO:0050774)2.45897279
123atrial cardiac muscle cell action potential (GO:0086014)2.44683858
124fatty acid transmembrane transport (GO:1902001)2.44436434
125negative regulation of sodium ion transport (GO:0010766)2.44410269
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43704954
127regulation of cAMP-dependent protein kinase activity (GO:2000479)2.43643938
128glycine transport (GO:0015816)2.43451954
129heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.43451089
130short-term memory (GO:0007614)2.43068214
131positive regulation of lipid catabolic process (GO:0050996)2.42306028
132gamma-aminobutyric acid transport (GO:0015812)2.41105663
133protein heterotrimerization (GO:0070208)2.41103949
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.41037150
135positive regulation of sodium ion transmembrane transport (GO:1902307)2.40431588
136artery development (GO:0060840)2.40242753
137insulin-like growth factor receptor signaling pathway (GO:0048009)2.40113770
138dorsal/ventral pattern formation (GO:0009953)2.39639245
139reflex (GO:0060004)2.39616739
140vesicle transport along microtubule (GO:0047496)2.39571658
141intraciliary transport (GO:0042073)2.39354778
142peristalsis (GO:0030432)2.38798030
143mating behavior (GO:0007617)2.38734154
144regulation of hippo signaling (GO:0035330)2.38393341
145activin receptor signaling pathway (GO:0032924)2.37286685
146calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37023838
147behavioral response to pain (GO:0048266)2.36950540
148specification of organ identity (GO:0010092)2.36808383
149regulation of fatty acid beta-oxidation (GO:0031998)2.36680604
150smoothened signaling pathway (GO:0007224)2.36613088
151negative regulation of cell fate commitment (GO:0010454)2.35021743
152positive regulation of cardiac muscle tissue development (GO:0055025)2.34263939
153positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33483347
154regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33434775
155negative regulation of vascular permeability (GO:0043116)2.33151400
156forebrain morphogenesis (GO:0048853)2.32729931
157spinal cord development (GO:0021510)2.32526432
158cilium or flagellum-dependent cell motility (GO:0001539)2.30944165
159endocardial cushion development (GO:0003197)2.30523977
160membrane repolarization (GO:0086009)2.30513170
161negative regulation of humoral immune response (GO:0002921)2.30194726
162membrane hyperpolarization (GO:0060081)2.29818192
163renal tubule morphogenesis (GO:0061333)2.29731066
164glucocorticoid receptor signaling pathway (GO:0042921)2.29424897
165dendritic spine morphogenesis (GO:0060997)2.29387341
166layer formation in cerebral cortex (GO:0021819)2.29383911
167locomotory exploration behavior (GO:0035641)2.28468152
168cell surface receptor signaling pathway involved in heart development (GO:0061311)2.28450795
169regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.28272859
170axis elongation (GO:0003401)2.27477266
171cranial suture morphogenesis (GO:0060363)2.26636600
172cell adhesion mediated by integrin (GO:0033627)2.26635521
173head development (GO:0060322)2.25967315
174heparan sulfate proteoglycan metabolic process (GO:0030201)2.25696957
175serotonin metabolic process (GO:0042428)2.25048543
176adenosine metabolic process (GO:0046085)2.23064495
177white fat cell differentiation (GO:0050872)2.21463487
178regulation of p38MAPK cascade (GO:1900744)2.20281340
179glomerular filtration (GO:0003094)2.19963124
180regulation of clathrin-mediated endocytosis (GO:2000369)2.18075757
181suckling behavior (GO:0001967)2.16416441
182establishment of nucleus localization (GO:0040023)2.16144347
183renal filtration (GO:0097205)2.13933568
184fatty acid homeostasis (GO:0055089)2.13671412
185response to pain (GO:0048265)2.13323282
186innervation (GO:0060384)2.13244380
187dopamine receptor signaling pathway (GO:0007212)2.11084341
188regulation of sequestering of triglyceride (GO:0010889)2.10498216
189regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.10380177
190axon cargo transport (GO:0008088)2.10217994
191L-serine transport (GO:0015825)2.09111050
192positive regulation of fibroblast migration (GO:0010763)2.08908970
193sodium ion transmembrane transport (GO:0035725)2.08614327
194alpha-linolenic acid metabolic process (GO:0036109)2.08169181
195apoptotic cell clearance (GO:0043277)2.07950480
196neutral lipid catabolic process (GO:0046461)2.07394242
197acylglycerol catabolic process (GO:0046464)2.07394242
198regulation of synaptic vesicle exocytosis (GO:2000300)2.05817213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70648349
2ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68871488
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61856670
4ZNF274_21170338_ChIP-Seq_K562_Hela2.44838203
5GBX2_23144817_ChIP-Seq_PC3_Human2.28086466
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.18039194
7TAF15_26573619_Chip-Seq_HEK293_Human2.17282541
8FUS_26573619_Chip-Seq_HEK293_Human2.16046603
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12129499
10DROSHA_22980978_ChIP-Seq_HELA_Human2.05800561
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05212948
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03816927
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.03107934
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01786513
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01786513
16EWS_26573619_Chip-Seq_HEK293_Human2.01361824
17P300_19829295_ChIP-Seq_ESCs_Human1.97980692
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93540564
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91958879
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.91866496
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87014626
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86356470
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81250686
24* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80959623
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79617345
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79380858
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75911231
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75375681
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72674818
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71838796
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69916513
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69693751
33* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68738560
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.67421958
35* EED_16625203_ChIP-ChIP_MESCs_Mouse1.65326197
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64686954
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63450935
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59455609
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.59206630
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57382573
41* RNF2_27304074_Chip-Seq_NSC_Mouse1.56106992
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54185555
43* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53962692
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53792688
45ER_23166858_ChIP-Seq_MCF-7_Human1.53379135
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.53333162
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52052301
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50846504
49* EZH2_27304074_Chip-Seq_ESCs_Mouse1.49450093
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49448225
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.48188352
52* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47440999
53* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44637440
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44415246
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43920027
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.43826767
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.43472256
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42246443
59SMAD4_21799915_ChIP-Seq_A2780_Human1.41655491
60TCF4_23295773_ChIP-Seq_U87_Human1.40657678
61* KDM2B_26808549_Chip-Seq_K562_Human1.40440020
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39955687
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39172841
64CLOCK_20551151_ChIP-Seq_293T_Human1.38580534
65AHR_22903824_ChIP-Seq_MCF-7_Human1.37719203
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.36347613
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32702889
68EZH2_22144423_ChIP-Seq_EOC_Human1.30608391
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.30225103
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30209279
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26367271
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26039139
73* EZH2_27294783_Chip-Seq_ESCs_Mouse1.25958125
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25862716
75AR_21572438_ChIP-Seq_LNCaP_Human1.24977623
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24852218
77RUNX2_22187159_ChIP-Seq_PCA_Human1.23862042
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22031501
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21935336
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21186121
81* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21128336
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.20940349
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20164612
84TCF4_22108803_ChIP-Seq_LS180_Human1.19913731
85* TCF4_18268006_ChIP-ChIP_LS174T_Human1.19513299
86* SMAD4_21741376_ChIP-Seq_HESCs_Human1.19286428
87CBP_20019798_ChIP-Seq_JUKART_Human1.18968725
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18968725
89* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18936486
90* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18687017
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18448026
92AR_19668381_ChIP-Seq_PC3_Human1.18233570
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.16642314
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16541719
95VDR_22108803_ChIP-Seq_LS180_Human1.16364119
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16086299
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15506122
98* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14772776
99STAT3_23295773_ChIP-Seq_U87_Human1.13645723
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.13460673
101TP53_16413492_ChIP-PET_HCT116_Human1.13352089
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.12512707
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12487506
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.12453295
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11621548
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11206336
107RXR_22158963_ChIP-Seq_LIVER_Mouse1.10736498
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10340277
109* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10205618
110* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09989324
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09481901
112* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08033377
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07757350
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06994183
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.06675084
116RXR_22108803_ChIP-Seq_LS180_Human1.06365992
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05648252
118* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05382195
119BCAT_22108803_ChIP-Seq_LS180_Human1.05094362
120TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04924969
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04824798
122TP53_18474530_ChIP-ChIP_U2OS_Human1.04682055
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04526033
124SOX2_19829295_ChIP-Seq_ESCs_Human1.04312724
125NANOG_19829295_ChIP-Seq_ESCs_Human1.04312724
126TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04143501
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04038670
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.03675357
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03638333
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03144572
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03069780
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02886872
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02683438
134ISL1_27105846_Chip-Seq_CPCs_Mouse1.02510824
135YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02365761
136RARB_27405468_Chip-Seq_BRAIN_Mouse1.02006357
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01915559
138RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01599829
139ESR1_21235772_ChIP-Seq_MCF-7_Human1.01289879
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.99448394
141STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97022537
142IGF1R_20145208_ChIP-Seq_DFB_Human0.93558499
143AR_25329375_ChIP-Seq_VCAP_Human0.93310935
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.92442590
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.92442590
146KDM2B_26808549_Chip-Seq_DND41_Human0.91463695
147ZNF263_19887448_ChIP-Seq_K562_Human0.91299112
148* REST_21632747_ChIP-Seq_MESCs_Mouse0.90701920
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89853182
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89853182
151* CJUN_26792858_Chip-Seq_BT549_Human0.89274810
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89235811
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89114584
154MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88765451
155* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88191717
156RING1B_27294783_Chip-Seq_ESCs_Mouse0.87924922
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.87562695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception5.02546742
2MP0002736_abnormal_nociception_after4.61095256
3MP0000566_synostosis4.52173853
4MP0002735_abnormal_chemical_nociception4.15406553
5MP0005670_abnormal_white_adipose3.70798381
6MP0008438_abnormal_cutaneous_collagen3.02788833
7MP0002733_abnormal_thermal_nociception2.94848564
8MP0002938_white_spotting2.89581176
9MP0010030_abnormal_orbit_morphology2.84398800
10MP0004858_abnormal_nervous_system2.65273386
11MP0009780_abnormal_chondrocyte_physiolo2.55148340
12MP0000569_abnormal_digit_pigmentation2.54359031
13MP0004130_abnormal_muscle_cell2.44909967
14MP0004270_analgesia2.43345388
15MP0002734_abnormal_mechanical_nocicepti2.40520755
16MP0005171_absent_coat_pigmentation2.40434787
17MP0003937_abnormal_limbs/digits/tail_de2.18729637
18MP0002837_dystrophic_cardiac_calcinosis2.17449493
19MP0003045_fibrosis2.17210776
20MP0003880_abnormal_central_pattern2.14908561
21MP0003136_yellow_coat_color2.01332937
22MP0001970_abnormal_pain_threshold2.01104634
23MP0003705_abnormal_hypodermis_morpholog2.00640082
24MP0008877_abnormal_DNA_methylation2.00446532
25MP0005646_abnormal_pituitary_gland1.98726212
26MP0005666_abnormal_adipose_tissue1.87615063
27MP0006292_abnormal_olfactory_placode1.87508653
28MP0000631_abnormal_neuroendocrine_gland1.85390035
29MP0005275_abnormal_skin_tensile1.78547713
30MP0006072_abnormal_retinal_apoptosis1.77628786
31MP0003122_maternal_imprinting1.76571889
32MP0004859_abnormal_synaptic_plasticity1.74379821
33MP0000778_abnormal_nervous_system1.73229368
34MP0003787_abnormal_imprinting1.72810288
35MP0001986_abnormal_taste_sensitivity1.71384017
36MP0003938_abnormal_ear_development1.68886905
37MP0001984_abnormal_olfaction1.66500466
38MP0006276_abnormal_autonomic_nervous1.65928077
39MP0004742_abnormal_vestibular_system1.65410680
40MP0000751_myopathy1.63480466
41MP0002102_abnormal_ear_morphology1.62984551
42MP0004142_abnormal_muscle_tone1.62428482
43MP0000026_abnormal_inner_ear1.62010191
44MP0004084_abnormal_cardiac_muscle1.60108493
45MP0000383_abnormal_hair_follicle1.58991560
46MP0004185_abnormal_adipocyte_glucose1.56018708
47MP0010329_abnormal_lipoprotein_level1.53691173
48MP0002638_abnormal_pupillary_reflex1.53036858
49MP0001661_extended_life_span1.52617659
50MP0004133_heterotaxia1.52288399
51MP0001299_abnormal_eye_distance/1.50332141
52MP0002653_abnormal_ependyma_morphology1.50042821
53MP0005253_abnormal_eye_physiology1.50022423
54MP0000579_abnormal_nail_morphology1.49832787
55MP0000049_abnormal_middle_ear1.44414360
56MP0005248_abnormal_Harderian_gland1.44406417
57MP0003942_abnormal_urinary_system1.42824494
58MP0004215_abnormal_myocardial_fiber1.42009418
59MP0005375_adipose_tissue_phenotype1.40593101
60MP0003566_abnormal_cell_adhesion1.40375421
61MP0000427_abnormal_hair_cycle1.38817968
62MP0001486_abnormal_startle_reflex1.36195108
63MP0001293_anophthalmia1.34002122
64MP0004272_abnormal_basement_membrane1.33982472
65MP0002233_abnormal_nose_morphology1.31865061
66MP0003890_abnormal_embryonic-extraembry1.30106351
67MP0002272_abnormal_nervous_system1.29028753
68MP0003195_calcinosis1.27898709
69MP0009745_abnormal_behavioral_response1.27129521
70MP0010368_abnormal_lymphatic_system1.26471539
71MP0008789_abnormal_olfactory_epithelium1.26417731
72MP0004885_abnormal_endolymph1.26352196
73MP0003300_gastrointestinal_ulcer1.26303075
74MP0004036_abnormal_muscle_relaxation1.23795829
75MP0001270_distended_abdomen1.22389346
76MP0009250_abnormal_appendicular_skeleto1.21272492
77MP0000534_abnormal_ureter_morphology1.20387257
78MP0005365_abnormal_bile_salt1.19217084
79MP0000013_abnormal_adipose_tissue1.19158610
80MP0008961_abnormal_basal_metabolism1.17567411
81MP0008775_abnormal_heart_ventricle1.16123170
82MP0003011_delayed_dark_adaptation1.15286583
83MP0003635_abnormal_synaptic_transmissio1.15177943
84MP0001958_emphysema1.14863147
85MP0003119_abnormal_digestive_system1.14349853
86MP0001346_abnormal_lacrimal_gland1.12018951
87MP0003279_aneurysm1.10928411
88MP0002067_abnormal_sensory_capabilities1.09581638
89MP0004145_abnormal_muscle_electrophysio1.09533411
90MP0005367_renal/urinary_system_phenotyp1.09068831
91MP0000516_abnormal_urinary_system1.09068831
92MP0006138_congestive_heart_failure1.08561313
93MP0004147_increased_porphyrin_level1.08046772
94MP0005174_abnormal_tail_pigmentation1.07750047
95MP0004233_abnormal_muscle_weight1.07738939
96MP0000955_abnormal_spinal_cord1.07332541
97MP0005334_abnormal_fat_pad1.06759242
98MP0009046_muscle_twitch1.05777370
99MP0003329_amyloid_beta_deposits1.04787988
100MP0005623_abnormal_meninges_morphology1.03521534
101MP0001963_abnormal_hearing_physiology1.03394783
102MP0003633_abnormal_nervous_system1.03308008
103MP0002282_abnormal_trachea_morphology1.01759200
104MP0004087_abnormal_muscle_fiber1.01406372
105MP0001485_abnormal_pinna_reflex1.00853595
106MP0002751_abnormal_autonomic_nervous1.00309893
107MP0005391_vision/eye_phenotype1.00156631
108MP0002752_abnormal_somatic_nervous1.00153025
109MP0003646_muscle_fatigue1.00025781
110MP0002572_abnormal_emotion/affect_behav0.99047697
111MP0005083_abnormal_biliary_tract0.97265908
112MP0005423_abnormal_somatic_nervous0.97143168
113MP0005195_abnormal_posterior_eye0.97117797
114MP0010352_gastrointestinal_tract_polyps0.96995833
115MP0003121_genomic_imprinting0.96955698
116MP0003755_abnormal_palate_morphology0.96600343
117MP0002249_abnormal_larynx_morphology0.95791829
118MP0002557_abnormal_social/conspecific_i0.95165635
119MP0002160_abnormal_reproductive_system0.95105512
120MP0001756_abnormal_urination0.94754044
121MP0005620_abnormal_muscle_contractility0.93984944
122MP0003091_abnormal_cell_migration0.93270721
123MP0005499_abnormal_olfactory_system0.91849324
124MP0005394_taste/olfaction_phenotype0.91849324
125MP0000428_abnormal_craniofacial_morphol0.90492680
126MP0005167_abnormal_blood-brain_barrier0.90486098
127MP0004811_abnormal_neuron_physiology0.90370378
128MP0003861_abnormal_nervous_system0.90227420
129MP0010386_abnormal_urinary_bladder0.87582590
130MP0003385_abnormal_body_wall0.87259398
131MP0005360_urolithiasis0.87130893
132MP0000003_abnormal_adipose_tissue0.86858200
133MP0005503_abnormal_tendon_morphology0.85587129
134MP0009115_abnormal_fat_cell0.85149018
135MP0002972_abnormal_cardiac_muscle0.85096267
136MP0002184_abnormal_innervation0.85091285
137MP0005084_abnormal_gallbladder_morpholo0.84602002
138MP0002168_other_aberrant_phenotype0.84516475
139MP0005076_abnormal_cell_differentiation0.84307179
140MP0010678_abnormal_skin_adnexa0.84118341
141MP0002909_abnormal_adrenal_gland0.83578091
142MP0002269_muscular_atrophy0.82692183
143MP0002116_abnormal_craniofacial_bone0.82686641
144MP0002118_abnormal_lipid_homeostasis0.82528246
145MP0005551_abnormal_eye_electrophysiolog0.80765373
146MP0002876_abnormal_thyroid_physiology0.80398920
147MP0000537_abnormal_urethra_morphology0.79686306
148MP0001324_abnormal_eye_pigmentation0.79646874
149MP0003137_abnormal_impulse_conducting0.79578692
150MP0010630_abnormal_cardiac_muscle0.77519510
151MP0001501_abnormal_sleep_pattern0.77470336
152MP0003631_nervous_system_phenotype0.77403058
153MP0003690_abnormal_glial_cell0.75863361
154MP0004883_abnormal_blood_vessel0.75591840
155MP0000759_abnormal_skeletal_muscle0.75450659
156MP0000747_muscle_weakness0.74849915
157MP0003115_abnormal_respiratory_system0.74223620
158MP0010234_abnormal_vibrissa_follicle0.73835500
159MP0009384_cardiac_valve_regurgitation0.73565283
160MP0002971_abnormal_brown_adipose0.71504734
161MP0002108_abnormal_muscle_morphology0.71055121
162MP0002063_abnormal_learning/memory/cond0.70413136
163MP0000733_abnormal_muscle_development0.69279186
164MP0009278_abnormal_bone_marrow0.68822321
165MP0005187_abnormal_penis_morphology0.67962980
166MP0000604_amyloidosis0.66224343
167MP0004085_abnormal_heartbeat0.66009758
168MP0010771_integument_phenotype0.65104044
169MP0005385_cardiovascular_system_phenoty0.63799054
170MP0001544_abnormal_cardiovascular_syste0.63799054
171MP0002064_seizures0.63447346
172MP0002166_altered_tumor_susceptibility0.62883710
173MP0008874_decreased_physiological_sensi0.62411682
174MP0003283_abnormal_digestive_organ0.61844785

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.75430102
2Pancreatic cysts (HP:0001737)3.66953219
3Nephronophthisis (HP:0000090)3.60333559
4Broad metatarsal (HP:0001783)3.55879540
5Action tremor (HP:0002345)3.51762440
6Abnormality of midbrain morphology (HP:0002418)3.44082373
7Molar tooth sign on MRI (HP:0002419)3.44082373
8Hyperventilation (HP:0002883)3.43054847
9Abnormality of the phalanges of the 2nd finger (HP:0009541)3.39325588
10Hyporeflexia of lower limbs (HP:0002600)3.36942792
11Impaired pain sensation (HP:0007328)3.35351234
12Abnormality of pain sensation (HP:0010832)3.35351234
13Tubular atrophy (HP:0000092)3.27660313
14True hermaphroditism (HP:0010459)3.15369934
15Abnormality of the renal medulla (HP:0100957)3.09049851
16Focal seizures (HP:0007359)2.98965107
17Genital tract atresia (HP:0001827)2.95899434
18Medial flaring of the eyebrow (HP:0010747)2.91334293
19Enlarged penis (HP:0000040)2.91124971
20Increased connective tissue (HP:0009025)2.88857438
21Aplasia/Hypoplasia of the tibia (HP:0005772)2.84107307
22Short hallux (HP:0010109)2.82649635
23Shallow orbits (HP:0000586)2.81518087
24Vaginal atresia (HP:0000148)2.77839437
25Aortic aneurysm (HP:0004942)2.77125493
26Cerebral aneurysm (HP:0004944)2.75361360
27Congenital sensorineural hearing impairment (HP:0008527)2.73265519
28Increased corneal curvature (HP:0100692)2.69242104
29Keratoconus (HP:0000563)2.69242104
30Congenital stationary night blindness (HP:0007642)2.65773925
31Aplasia/Hypoplasia of the hallux (HP:0008362)2.63210427
32Vitreoretinal degeneration (HP:0000655)2.61579174
33Hypoplasia of the pons (HP:0012110)2.60789900
34Gait imbalance (HP:0002141)2.57890577
35Cutaneous finger syndactyly (HP:0010554)2.57519952
36Hammertoe (HP:0001765)2.57137550
37Flat cornea (HP:0007720)2.56327988
38Dysautonomia (HP:0002459)2.55984848
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.54090427
40Hand muscle atrophy (HP:0009130)2.52369468
41Termporal pattern (HP:0011008)2.51318995
42Insidious onset (HP:0003587)2.51318995
43Renal duplication (HP:0000075)2.49237992
44Macroorchidism (HP:0000053)2.49120575
45Preaxial foot polydactyly (HP:0001841)2.48408663
46Congenital primary aphakia (HP:0007707)2.46384149
47Stenosis of the external auditory canal (HP:0000402)2.44476816
48Elfin facies (HP:0004428)2.43737926
49Oligomenorrhea (HP:0000876)2.42490872
50Cystic liver disease (HP:0006706)2.42417999
51Hypoventilation (HP:0002791)2.40887603
52Abnormality of the middle phalanges of the toes (HP:0010183)2.40862414
53Oligodactyly (hands) (HP:0001180)2.40070972
54Abnormality of the labia minora (HP:0012880)2.39418104
55Distal upper limb amyotrophy (HP:0007149)2.39364575
56Upper limb amyotrophy (HP:0009129)2.39364575
57Hypoplastic labia majora (HP:0000059)2.38417819
58Hyperacusis (HP:0010780)2.37949959
59Long nose (HP:0003189)2.37127324
60Striae distensae (HP:0001065)2.37092553
61Bowel diverticulosis (HP:0005222)2.36514986
62Difficulty running (HP:0009046)2.36400719
63Testicular neoplasm (HP:0010788)2.35632517
64Abnormality of the pons (HP:0007361)2.34067238
65Short tibia (HP:0005736)2.31894471
66Lymphangioma (HP:0100764)2.29784495
67Coronal craniosynostosis (HP:0004440)2.29769836
68Type II lissencephaly (HP:0007260)2.27975807
69Ulnar claw (HP:0001178)2.27093648
70Nephrogenic diabetes insipidus (HP:0009806)2.26871401
71Renovascular hypertension (HP:0100817)2.24967595
72Protrusio acetabuli (HP:0003179)2.24316388
73Bladder diverticulum (HP:0000015)2.23965692
74Ankle contracture (HP:0006466)2.23548086
75Chorioretinal atrophy (HP:0000533)2.23379611
76Abnormality of the renal cortex (HP:0011035)2.22994838
77Hypoplastic ischia (HP:0003175)2.22538061
78Synostosis of carpal bones (HP:0005048)2.20823655
79Abnormality of the labia majora (HP:0012881)2.20107274
80Mitral valve prolapse (HP:0001634)2.19327008
81Split foot (HP:0001839)2.16255021
82Neoplasm of the heart (HP:0100544)2.15924865
83Cutaneous syndactyly (HP:0012725)2.15667193
84Muscle fiber splitting (HP:0003555)2.14608050
85Polydipsia (HP:0001959)2.14465194
86Abnormal drinking behavior (HP:0030082)2.14465194
87Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.13047639
88Turricephaly (HP:0000262)2.12506362
89Tetraparesis (HP:0002273)2.12300503
90Hypoplasia of the ulna (HP:0003022)2.11987411
91Chronic hepatic failure (HP:0100626)2.11981650
92Hypercortisolism (HP:0001578)2.10183219
93Aplasia involving bones of the upper limbs (HP:0009823)2.09954288
94Aplasia of the phalanges of the hand (HP:0009802)2.09954288
95Aplasia involving bones of the extremities (HP:0009825)2.09954288
96Aqueductal stenosis (HP:0002410)2.09517167
97Aneurysm (HP:0002617)2.07869400
98Myotonia (HP:0002486)2.07715268
99Gaze-evoked nystagmus (HP:0000640)2.06876105
100Anencephaly (HP:0002323)2.06603769
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03872808
102Right ventricular cardiomyopathy (HP:0011663)2.03090508
103Postaxial hand polydactyly (HP:0001162)2.02814582
104Long toe (HP:0010511)2.02041228
105Labial hypoplasia (HP:0000066)2.00805510
106Dilatation of the ascending aorta (HP:0005111)2.00584480
107Preaxial hand polydactyly (HP:0001177)1.97563448
108Buphthalmos (HP:0000557)1.97507332
109Oligodactyly (HP:0012165)1.97337226
110Optic nerve hypoplasia (HP:0000609)1.97325478
111Occipital encephalocele (HP:0002085)1.96207678
112Cerebellar dysplasia (HP:0007033)1.95774071
113Atonic seizures (HP:0010819)1.94315942
114Insomnia (HP:0100785)1.93456050
115Complement deficiency (HP:0004431)1.93378950
116Type 1 muscle fiber predominance (HP:0003803)1.92862835
117Sclerocornea (HP:0000647)1.92033469
118Abnormality of cochlea (HP:0000375)1.91615362
119Premature rupture of membranes (HP:0001788)1.91296676
120Aortic dissection (HP:0002647)1.89745103
121Febrile seizures (HP:0002373)1.89397424
122Abnormality of the 4th metacarpal (HP:0010012)1.88809055
123Abnormality of the 2nd finger (HP:0004100)1.88062747
124Increased variability in muscle fiber diameter (HP:0003557)1.87721016
125Postaxial foot polydactyly (HP:0001830)1.87649815
126Narrow palate (HP:0000189)1.87497545
127Pigmentary retinal degeneration (HP:0001146)1.86728268
128Pointed chin (HP:0000307)1.86454971
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84926147
130Congenital, generalized hypertrichosis (HP:0004540)1.84671266
131Poor coordination (HP:0002370)1.84613532
132Sensory axonal neuropathy (HP:0003390)1.82644681
133Aplasia/Hypoplasia of the ulna (HP:0006495)1.82468086
134Failure to thrive in infancy (HP:0001531)1.81986507
135Furrowed tongue (HP:0000221)1.80830655
136Acanthosis nigricans (HP:0000956)1.80592713
137Precocious puberty (HP:0000826)1.80509448
138Attenuation of retinal blood vessels (HP:0007843)1.80120093
139Rib fusion (HP:0000902)1.79925545
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79104670
141Skin nodule (HP:0200036)1.78811603
142Short foot (HP:0001773)1.78287264
143Growth hormone excess (HP:0000845)1.77509458
144Gastrointestinal atresia (HP:0002589)1.76916798
145Exotropia (HP:0000577)1.75674175
146Steppage gait (HP:0003376)1.74432228
147Urinary bladder sphincter dysfunction (HP:0002839)1.74105107
148Atrophic scars (HP:0001075)1.73840187
149Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73408534
150Short 4th metacarpal (HP:0010044)1.73408534
151Progressive cerebellar ataxia (HP:0002073)1.72820416
152Supernumerary spleens (HP:0009799)1.71856679
153Absent speech (HP:0001344)1.71485018
154Congenital hepatic fibrosis (HP:0002612)1.71295930
155Hypoplastic female external genitalia (HP:0012815)1.70429618
156Renal dysplasia (HP:0000110)1.70348362
157Prolonged QT interval (HP:0001657)1.69539277
158Abnormal respiratory motile cilium morphology (HP:0005938)1.69310841
159Abnormal respiratory epithelium morphology (HP:0012253)1.69310841
160Ectopic kidney (HP:0000086)1.69173550
161Abnormality of the proximal phalanges of the hand (HP:0009834)1.68119233
162Onion bulb formation (HP:0003383)1.68020774
163Gonadal dysgenesis (HP:0000133)1.67621071
164Morphological abnormality of the inner ear (HP:0011390)1.67103721
165Abnormality of the phalanges of the 5th finger (HP:0004213)1.66815303
166Hemiparesis (HP:0001269)1.66164105
167Deep venous thrombosis (HP:0002625)1.66135629
168Torticollis (HP:0000473)1.66079772
169Dynein arm defect of respiratory motile cilia (HP:0012255)1.65416967
170Absent/shortened dynein arms (HP:0200106)1.65416967
171Urinary urgency (HP:0000012)1.64771123
172Lissencephaly (HP:0001339)1.64654017
173Fibular hypoplasia (HP:0003038)1.63851496
174Abnormality of the lower motor neuron (HP:0002366)1.63325350
175Tubulointerstitial fibrosis (HP:0005576)1.62824416
176Hematochezia (HP:0002573)1.61878273
177Epileptic encephalopathy (HP:0200134)1.61762042
178Genetic anticipation (HP:0003743)1.61384968
179Myokymia (HP:0002411)1.61122726
180Abnormality of the ischium (HP:0003174)1.60095805
181Lower limb muscle weakness (HP:0007340)1.58768860
182Bradycardia (HP:0001662)1.57877359
183Anosmia (HP:0000458)1.57791187
184Abnormality of the corticospinal tract (HP:0002492)1.56275237
185Menstrual irregularities (HP:0000858)1.55457281
186Hepatoblastoma (HP:0002884)1.55449390
187Camptodactyly of toe (HP:0001836)1.55027991
188Central scotoma (HP:0000603)1.54555310
189Supranuclear gaze palsy (HP:0000605)1.53439938
190Broad palm (HP:0001169)1.53317593
191Syncope (HP:0001279)1.53186130
192Genu recurvatum (HP:0002816)1.53048874
193Impaired social interactions (HP:0000735)1.51985094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D3.49909409
2BMPR1B3.35029470
3ACVR1B3.27338285
4CAMK1G3.26252161
5CASK3.23578696
6NTRK12.71624098
7LMTK22.67973829
8SIK12.59093900
9DAPK22.44912431
10WNK42.38013207
11RIPK12.21543789
12MAP3K92.13061760
13TRIB32.12819262
14TNIK2.10146647
15GRK11.99587347
16ADRBK21.97298393
17LATS21.93604077
18MAP3K21.89105766
19PINK11.88487879
20NTRK31.88199344
21WNK31.87087999
22STK391.85006389
23PDGFRA1.83977397
24ERN11.82540788
25TTN1.78447376
26PAK61.77805827
27FGFR21.70527318
28KSR21.69793775
29STK38L1.67717890
30TGFBR11.66255355
31PHKG21.65736172
32PHKG11.65736172
33RIPK41.61788812
34ZAK1.55918076
35DDR21.53149710
36MINK11.49896956
37RET1.46414112
38EPHA41.45007607
39MAPK131.43291280
40BCR1.41149234
41PKN21.36659271
42NUAK11.36553986
43FRK1.34639960
44EPHA31.33111305
45LATS11.29387084
46PNCK1.28814714
47NEK91.27318016
48ICK1.25055317
49EPHB21.24695546
50PIK3CA1.21188157
51FGFR31.19952331
52STK381.18377116
53DYRK21.17661994
54PRKCG1.15333656
55MKNK21.15142670
56PDGFRB1.14822794
57INSRR1.14566485
58EPHB11.11608160
59NTRK21.09540837
60MAP2K71.09251012
61FGFR41.06226381
62PRKD31.06211423
63PTK21.03983858
64FER1.02947868
65MYLK0.99820138
66ADRBK10.98644515
67JAK10.98597940
68MET0.98294028
69CDK30.97594957
70WNK10.96735001
71GRK50.95619826
72MAP3K40.93643499
73NEK10.92339701
74RPS6KA20.91336201
75MTOR0.90971572
76SGK30.87190238
77MUSK0.86531535
78DYRK30.86516301
79OXSR10.85256128
80ERBB20.84990793
81AKT30.84708896
82MAP4K20.84221162
83CAMKK10.84141191
84WEE10.82888683
85PAK30.81436346
86FLT30.78714850
87MARK30.78204589
88CDK120.76663078
89MAP2K40.76077769
90CAMK2A0.75694451
91SIK20.75000248
92PTK60.74930837
93STK30.73039717
94PRKCH0.72692369
95NLK0.71945678
96PTK2B0.70756509
97CDK50.69116706
98JAK20.68771147
99PLK20.67730265
100SGK2230.67684067
101SGK4940.67684067
102PKN10.66803614
103FGFR10.66319724
104SGK20.65732343
105MAPK150.65667151
106CAMKK20.65272302
107PDK10.64615163
108MARK10.64135469
109STK110.63956750
110PRKAA20.63868919
111PRKAA10.63590016
112MAP3K70.63390521
113MAP2K10.63388508
114CDC42BPA0.63024247
115CSNK1G20.60400798
116MATK0.60098445
117FYN0.58314746
118MAP3K10.58286257
119MAPK100.58219667
120TGFBR20.57118551
121SRC0.57048885
122TRIM280.55323196
123CAMK2D0.54197463
124TIE10.54007533
125ERBB30.53640617
126TLK10.53611627
127MST1R0.53183674
128PRKCZ0.52756342
129DYRK1A0.52015137
130PDPK10.51897904
131MKNK10.50013956
132CAMK40.49404237
133RPS6KA40.49219991
134PRKCE0.48074437
135OBSCN0.48063675
136PRKACA0.47737168
137LIMK10.47627239
138CDK140.46734301
139CAMK10.46265767
140PRKD10.45295171
141STK160.45239824
142CSNK1A1L0.44038261
143CAMK2B0.43875157
144ALK0.42941943
145RPS6KA30.42922198
146TNK20.42552100
147MARK20.41867737
148CSNK1A10.40785273
149MELK0.40698185
150BRSK20.40477194
151PIK3CG0.40353345
152SGK10.39767934
153DAPK10.39575909
154MAP3K100.39298502
155CSNK1D0.38604282
156PRKG10.37833560
157BMX0.37665492
158CAMK2G0.37604748
159ROCK10.37199765
160CDK60.36880801
161UHMK10.33530653
162CSNK1G10.32682455

Predicted pathways (KEGG)

RankGene SetZ-score
1* Hedgehog signaling pathway_Homo sapiens_hsa043403.74690760
2* Basal cell carcinoma_Homo sapiens_hsa052173.63560326
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46373580
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.07682463
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05420388
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94892277
7* Hippo signaling pathway_Homo sapiens_hsa043901.94827986
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.89406497
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83733806
10Butanoate metabolism_Homo sapiens_hsa006501.79995397
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77971598
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.77762805
13Linoleic acid metabolism_Homo sapiens_hsa005911.77480866
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72898302
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71891134
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67911468
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67849098
18* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.67199040
19Protein export_Homo sapiens_hsa030601.67006462
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65969707
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58381636
22Type II diabetes mellitus_Homo sapiens_hsa049301.54926857
23Nitrogen metabolism_Homo sapiens_hsa009101.49348505
24Ether lipid metabolism_Homo sapiens_hsa005651.45565025
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44358196
26PPAR signaling pathway_Homo sapiens_hsa033201.38549742
27Glycerolipid metabolism_Homo sapiens_hsa005611.36085843
28Circadian entrainment_Homo sapiens_hsa047131.35255890
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33197181
30Salivary secretion_Homo sapiens_hsa049701.32864857
31Synaptic vesicle cycle_Homo sapiens_hsa047211.32118909
32* Wnt signaling pathway_Homo sapiens_hsa043101.27848802
33Selenocompound metabolism_Homo sapiens_hsa004501.27128704
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26472641
35TGF-beta signaling pathway_Homo sapiens_hsa043501.24252373
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23995538
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22233640
38mTOR signaling pathway_Homo sapiens_hsa041501.22233240
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22058030
40Insulin secretion_Homo sapiens_hsa049111.21653360
41Nicotine addiction_Homo sapiens_hsa050331.20851422
42Oxidative phosphorylation_Homo sapiens_hsa001901.15799289
43Renin secretion_Homo sapiens_hsa049241.15599312
44Insulin signaling pathway_Homo sapiens_hsa049101.15500708
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.15321968
46Insulin resistance_Homo sapiens_hsa049311.14788728
47Bile secretion_Homo sapiens_hsa049761.14381884
48Homologous recombination_Homo sapiens_hsa034401.14286128
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13912135
50Morphine addiction_Homo sapiens_hsa050321.13263175
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12007826
52Cocaine addiction_Homo sapiens_hsa050301.11753799
53Dilated cardiomyopathy_Homo sapiens_hsa054141.11669558
54Dorso-ventral axis formation_Homo sapiens_hsa043201.11164133
55Chemical carcinogenesis_Homo sapiens_hsa052041.08674386
56GABAergic synapse_Homo sapiens_hsa047271.07925497
57Glutamatergic synapse_Homo sapiens_hsa047241.07302212
58Cardiac muscle contraction_Homo sapiens_hsa042601.06909155
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06408849
60Cholinergic synapse_Homo sapiens_hsa047251.05359844
61Fanconi anemia pathway_Homo sapiens_hsa034601.04958281
62AMPK signaling pathway_Homo sapiens_hsa041521.04223370
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03122763
64Lysine degradation_Homo sapiens_hsa003101.02656869
65Fatty acid biosynthesis_Homo sapiens_hsa000611.02591630
66Retinol metabolism_Homo sapiens_hsa008301.01501842
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01385499
68Long-term potentiation_Homo sapiens_hsa047200.98953839
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.98693829
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98043948
71Oxytocin signaling pathway_Homo sapiens_hsa049210.97864379
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.97599989
73GnRH signaling pathway_Homo sapiens_hsa049120.97205314
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.97060796
75Caffeine metabolism_Homo sapiens_hsa002320.96709196
76Dopaminergic synapse_Homo sapiens_hsa047280.96264688
77Glioma_Homo sapiens_hsa052140.93255498
78Estrogen signaling pathway_Homo sapiens_hsa049150.92871855
79Arginine biosynthesis_Homo sapiens_hsa002200.92649265
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91511960
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91137544
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90952077
83Gastric acid secretion_Homo sapiens_hsa049710.90879531
84ECM-receptor interaction_Homo sapiens_hsa045120.89990242
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89558729
86Protein digestion and absorption_Homo sapiens_hsa049740.87572070
87Focal adhesion_Homo sapiens_hsa045100.87491531
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87455600
89Glucagon signaling pathway_Homo sapiens_hsa049220.86645640
90Complement and coagulation cascades_Homo sapiens_hsa046100.86251147
91* Proteoglycans in cancer_Homo sapiens_hsa052050.86032597
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.85779443
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85194136
94Amoebiasis_Homo sapiens_hsa051460.84889622
95Calcium signaling pathway_Homo sapiens_hsa040200.84559054
96Endometrial cancer_Homo sapiens_hsa052130.83500660
97Olfactory transduction_Homo sapiens_hsa047400.82686442
98Staphylococcus aureus infection_Homo sapiens_hsa051500.82105810
99Fatty acid metabolism_Homo sapiens_hsa012120.81986169
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.81811503
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.81611656
102Basal transcription factors_Homo sapiens_hsa030220.81001305
103Thyroid hormone synthesis_Homo sapiens_hsa049180.79793907
104Axon guidance_Homo sapiens_hsa043600.76275005
105Fatty acid degradation_Homo sapiens_hsa000710.76171828
106cAMP signaling pathway_Homo sapiens_hsa040240.75513853
107Circadian rhythm_Homo sapiens_hsa047100.75019778
108Parkinsons disease_Homo sapiens_hsa050120.74953573
109Gap junction_Homo sapiens_hsa045400.74350080
110Long-term depression_Homo sapiens_hsa047300.73978898
111Histidine metabolism_Homo sapiens_hsa003400.73091418
112Rap1 signaling pathway_Homo sapiens_hsa040150.72111826
113Pancreatic secretion_Homo sapiens_hsa049720.71596421
114Choline metabolism in cancer_Homo sapiens_hsa052310.70357881
115Ovarian steroidogenesis_Homo sapiens_hsa049130.70038907
116Huntingtons disease_Homo sapiens_hsa050160.69807359
117Renin-angiotensin system_Homo sapiens_hsa046140.69094044
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67326112
119Alzheimers disease_Homo sapiens_hsa050100.67097658
120* Melanogenesis_Homo sapiens_hsa049160.66955779
121ErbB signaling pathway_Homo sapiens_hsa040120.66904337
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66883887
123Arachidonic acid metabolism_Homo sapiens_hsa005900.65878570
124Steroid biosynthesis_Homo sapiens_hsa001000.64134190
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63639196
126Viral myocarditis_Homo sapiens_hsa054160.63135039
127Fat digestion and absorption_Homo sapiens_hsa049750.61877211
128Non-small cell lung cancer_Homo sapiens_hsa052230.61675660
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61278018
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61177788
131Taste transduction_Homo sapiens_hsa047420.60522016
132Adherens junction_Homo sapiens_hsa045200.60448164
133Amphetamine addiction_Homo sapiens_hsa050310.59932026
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.56167595
135Serotonergic synapse_Homo sapiens_hsa047260.55271277
136Sulfur metabolism_Homo sapiens_hsa009200.54947725
137RNA polymerase_Homo sapiens_hsa030200.54883736
138Peroxisome_Homo sapiens_hsa041460.53729757
139Melanoma_Homo sapiens_hsa052180.53684843
140Propanoate metabolism_Homo sapiens_hsa006400.52111234
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51314073
142VEGF signaling pathway_Homo sapiens_hsa043700.51097838
143Phototransduction_Homo sapiens_hsa047440.50941539
144Tryptophan metabolism_Homo sapiens_hsa003800.50443698
145ABC transporters_Homo sapiens_hsa020100.50048720
146Chronic myeloid leukemia_Homo sapiens_hsa052200.49364901
147Platelet activation_Homo sapiens_hsa046110.49208016
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49100309
149Mineral absorption_Homo sapiens_hsa049780.47059587
150Tight junction_Homo sapiens_hsa045300.45810381
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44653219
152* Pathways in cancer_Homo sapiens_hsa052000.44024468
153Sphingolipid metabolism_Homo sapiens_hsa006000.43194773
154beta-Alanine metabolism_Homo sapiens_hsa004100.41943998
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40737786
156Fatty acid elongation_Homo sapiens_hsa000620.39913675

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