WNT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.98576303
2long-chain fatty acid biosynthetic process (GO:0042759)6.91564251
3ensheathment of neurons (GO:0007272)6.85868842
4axon ensheathment (GO:0008366)6.85868842
5myelination (GO:0042552)6.84488179
6cholesterol biosynthetic process (GO:0006695)5.51353304
7regulation of mesoderm development (GO:2000380)4.97145346
8regulation of DNA endoreduplication (GO:0032875)4.91750870
9sterol biosynthetic process (GO:0016126)4.80454862
10myelin maintenance (GO:0043217)4.72691278
11long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.46289192
12long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.35967209
13oligodendrocyte differentiation (GO:0048709)4.34318173
14isoprenoid biosynthetic process (GO:0008299)4.17957883
15cell migration involved in gastrulation (GO:0042074)4.12721192
16apical protein localization (GO:0045176)4.05831326
17asymmetric protein localization (GO:0008105)4.05078059
18creatine metabolic process (GO:0006600)4.04755512
19establishment of mitochondrion localization (GO:0051654)4.01475758
20substantia nigra development (GO:0021762)4.00029132
21sulfation (GO:0051923)3.97839559
22desmosome organization (GO:0002934)3.93640667
23negative regulation of protein localization to cell surface (GO:2000009)3.88331438
24negative regulation of neurotransmitter secretion (GO:0046929)3.85925404
25negative regulation of neurotransmitter transport (GO:0051589)3.83578609
26adhesion of symbiont to host cell (GO:0044650)3.83312373
27virion attachment to host cell (GO:0019062)3.83312373
28amyloid precursor protein metabolic process (GO:0042982)3.81487988
29* regulation of collateral sprouting (GO:0048670)3.79141017
30fatty-acyl-CoA metabolic process (GO:0035337)3.77978215
31fatty-acyl-CoA biosynthetic process (GO:0046949)3.73800891
32response to methylmercury (GO:0051597)3.72580935
33positive regulation of oligodendrocyte differentiation (GO:0048714)3.68364095
34glycerophospholipid catabolic process (GO:0046475)3.66957899
35anterior/posterior axis specification, embryo (GO:0008595)3.63677422
36lateral sprouting from an epithelium (GO:0060601)3.57593697
37astrocyte development (GO:0014002)3.56524356
38photoreceptor cell differentiation (GO:0046530)3.55775424
39eye photoreceptor cell differentiation (GO:0001754)3.55775424
40negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.55110364
41peptidyl-tyrosine autophosphorylation (GO:0038083)3.54759981
42otic vesicle formation (GO:0030916)3.52509829
43chromatin remodeling at centromere (GO:0031055)3.51117930
44peripheral nervous system axon ensheathment (GO:0032292)3.48182171
45myelination in peripheral nervous system (GO:0022011)3.48182171
46CENP-A containing nucleosome assembly (GO:0034080)3.44887943
47signal transduction involved in regulation of gene expression (GO:0023019)3.43720517
48presynaptic membrane organization (GO:0097090)3.42290722
49DNA double-strand break processing (GO:0000729)3.40368697
50response to redox state (GO:0051775)3.38260402
51replication fork processing (GO:0031297)3.35930085
52water-soluble vitamin biosynthetic process (GO:0042364)3.35700512
53response to lipoprotein particle (GO:0055094)3.31345625
54resolution of meiotic recombination intermediates (GO:0000712)3.29311089
55regulation of glomerulus development (GO:0090192)3.29106435
56cell proliferation in forebrain (GO:0021846)3.28424795
57endoderm formation (GO:0001706)3.27168988
58positive regulation of cellular amine metabolic process (GO:0033240)3.25895612
59histone exchange (GO:0043486)3.25290760
60positive regulation of protein autophosphorylation (GO:0031954)3.24807164
61L-amino acid import (GO:0043092)3.24601118
62protein palmitoylation (GO:0018345)3.23673469
63GPI anchor biosynthetic process (GO:0006506)3.18507976
64epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.12831732
65behavioral response to nicotine (GO:0035095)3.12595423
66very long-chain fatty acid metabolic process (GO:0000038)3.12482327
67GPI anchor metabolic process (GO:0006505)3.10304930
68enteric nervous system development (GO:0048484)3.09587423
69negative chemotaxis (GO:0050919)3.08263617
70keratinocyte development (GO:0003334)3.08093428
71retinal ganglion cell axon guidance (GO:0031290)3.03931464
72positive regulation of cardiac muscle cell differentiation (GO:2000727)3.02343859
73positive regulation of actin filament depolymerization (GO:0030836)3.00488037
74presynaptic membrane assembly (GO:0097105)3.00426299
75negative regulation of execution phase of apoptosis (GO:1900118)2.98847828
76import into cell (GO:0098657)2.98342677
77sphingoid metabolic process (GO:0046519)2.97139110
78peripheral nervous system development (GO:0007422)2.92801035
79kidney morphogenesis (GO:0060993)2.92536200
80cranial nerve development (GO:0021545)2.92267651
81somite rostral/caudal axis specification (GO:0032525)2.91003458
82cerebral cortex radially oriented cell migration (GO:0021799)2.89397281
83axon development (GO:0061564)2.88615637
84membrane tubulation (GO:0097320)2.87428137
85negative regulation of acute inflammatory response (GO:0002674)2.87305217
86somite development (GO:0061053)2.87259468
87magnesium ion transport (GO:0015693)2.87106120
88primitive streak formation (GO:0090009)2.87106109
89regulation of interleukin-13 production (GO:0032656)2.84244341
90negative regulation of DNA-dependent DNA replication (GO:2000104)2.82563581
91response to pheromone (GO:0019236)2.81338006
92neuron remodeling (GO:0016322)2.78848088
93sphingosine metabolic process (GO:0006670)2.77412188
94phosphatidylserine acyl-chain remodeling (GO:0036150)2.75941503
95thioester biosynthetic process (GO:0035384)2.74423278
96acyl-CoA biosynthetic process (GO:0071616)2.74423278
97positive regulation of glial cell differentiation (GO:0045687)2.73649204
98negative regulation of inclusion body assembly (GO:0090084)2.73528203
99neural nucleus development (GO:0048857)2.73093249
100negative regulation of cell fate commitment (GO:0010454)2.72879816
101regulation of lipoprotein metabolic process (GO:0050746)2.72540648
102ear development (GO:0043583)2.72304632
103negative regulation of activin receptor signaling pathway (GO:0032926)2.71291335
104DNA deamination (GO:0045006)2.71059319
105preassembly of GPI anchor in ER membrane (GO:0016254)2.70987771
106negative regulation of cardiac muscle tissue development (GO:0055026)2.69157781
107negative regulation of astrocyte differentiation (GO:0048712)2.69064456
108transmission of nerve impulse (GO:0019226)2.68196134
109kinetochore assembly (GO:0051382)2.67939075
110keratinization (GO:0031424)2.67504867
111vitamin catabolic process (GO:0009111)2.67187508
112fat-soluble vitamin catabolic process (GO:0042363)2.67187508
113DNA replication-dependent nucleosome organization (GO:0034723)2.67120348
114DNA replication-dependent nucleosome assembly (GO:0006335)2.67120348
115positive regulation of pseudopodium assembly (GO:0031274)2.66878990
116kinetochore organization (GO:0051383)2.66665133
117positive regulation of cell fate commitment (GO:0010455)2.65958948
118* negative regulation of axonogenesis (GO:0050771)2.65382387
119microtubule polymerization or depolymerization (GO:0031109)2.65226525
120protein neddylation (GO:0045116)2.64548216
121positive regulation of interleukin-4 production (GO:0032753)2.64540619
122adult walking behavior (GO:0007628)2.63974158
123* anterior/posterior axis specification (GO:0009948)2.63487892
124adhesion of symbiont to host (GO:0044406)2.62465149
125negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62267664
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61931720
127regulation of cell proliferation involved in kidney development (GO:1901722)2.61450005
128embryonic axis specification (GO:0000578)2.61142582
129protein K6-linked ubiquitination (GO:0085020)2.61084019
130pharyngeal system development (GO:0060037)2.60398346
131positive regulation of gliogenesis (GO:0014015)2.59115488
132regulation of water loss via skin (GO:0033561)2.58847320
133centriole replication (GO:0007099)2.58740520
134glial cell differentiation (GO:0010001)2.58725717
135peptidyl-cysteine modification (GO:0018198)2.57589807
136* dorsal/ventral axis specification (GO:0009950)2.57525712
137lung morphogenesis (GO:0060425)2.57451589
138regulation of somitogenesis (GO:0014807)2.55997147
139glycosylceramide metabolic process (GO:0006677)2.55327556
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.54881744
141positive regulation of action potential (GO:0045760)2.54477516
142positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.54297586
143neuron cell-cell adhesion (GO:0007158)2.53920646
144recombinational repair (GO:0000725)2.52756925
145double-strand break repair via homologous recombination (GO:0000724)2.52426319
146cellular response to epinephrine stimulus (GO:0071872)2.51082139
147pituitary gland development (GO:0021983)2.49871742
148DNA replication-independent nucleosome organization (GO:0034724)2.49434555
149DNA replication-independent nucleosome assembly (GO:0006336)2.49434555
150regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.49292751
151gastrulation (GO:0007369)2.49267481
152glutathione biosynthetic process (GO:0006750)2.47246269
153diol metabolic process (GO:0034311)2.45763319
154thalamus development (GO:0021794)2.44071948
155female gonad development (GO:0008585)2.43955329
156regulation of activin receptor signaling pathway (GO:0032925)2.43175258
157maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.42510259
158positive regulation of cardiac muscle tissue development (GO:0055025)2.40596337
159negative regulation of hormone biosynthetic process (GO:0032353)2.39160068
160regulation of gene silencing by RNA (GO:0060966)2.38043770
161regulation of posttranscriptional gene silencing (GO:0060147)2.38043770
162regulation of gene silencing by miRNA (GO:0060964)2.38043770
163protein complex biogenesis (GO:0070271)2.37932125
164G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37420514
165cardiac epithelial to mesenchymal transition (GO:0060317)2.37046561
166regulation of timing of cell differentiation (GO:0048505)2.36905311
167negative regulation of systemic arterial blood pressure (GO:0003085)2.36002743
168protein polyglutamylation (GO:0018095)2.35787798
169embryonic pattern specification (GO:0009880)2.35037748
170regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.34777307
171mitochondrial respiratory chain complex assembly (GO:0033108)2.34671834
172positive regulation of meiosis (GO:0045836)2.32809973
173nonmotile primary cilium assembly (GO:0035058)2.31624413
174cellular response to BMP stimulus (GO:0071773)2.31214274
175response to BMP (GO:0071772)2.31214274
176* embryonic hindlimb morphogenesis (GO:0035116)2.30448531
177cartilage morphogenesis (GO:0060536)2.30439174
178positive regulation of gastrulation (GO:2000543)2.29814769
179protein prenylation (GO:0018342)2.29127742
180prenylation (GO:0097354)2.29127742
181atrial cardiac muscle cell action potential (GO:0086014)2.29120697
182positive regulation of cardiac muscle tissue growth (GO:0055023)2.28840821
183mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.28698787
184mitochondrial respiratory chain complex I assembly (GO:0032981)2.28698787
185NADH dehydrogenase complex assembly (GO:0010257)2.28698787
186cellular response to ATP (GO:0071318)2.28566305
187negative regulation of appetite (GO:0032099)2.27670443
188negative regulation of response to food (GO:0032096)2.27670443
189regulation of phospholipid biosynthetic process (GO:0071071)2.27559143
190photoreceptor cell development (GO:0042461)2.27357619
191detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26836148
192axon ensheathment in central nervous system (GO:0032291)11.6003874
193central nervous system myelination (GO:0022010)11.6003874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.67285726
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.84795070
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77908196
4EWS_26573619_Chip-Seq_HEK293_Human2.55279056
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47898607
6IGF1R_20145208_ChIP-Seq_DFB_Human2.43606409
7ZNF274_21170338_ChIP-Seq_K562_Hela2.32816507
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26894429
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.24092705
10* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.23030932
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21443007
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21156103
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16956594
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.16944435
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10522368
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10007766
17GBX2_23144817_ChIP-Seq_PC3_Human2.08115112
18TAF15_26573619_Chip-Seq_HEK293_Human2.02799298
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00376767
20VDR_22108803_ChIP-Seq_LS180_Human2.00102867
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92331728
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92290920
23* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92290920
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91188813
25* EED_16625203_ChIP-ChIP_MESCs_Mouse1.90919415
26EZH2_22144423_ChIP-Seq_EOC_Human1.89961811
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88955777
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88501342
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.86648729
30* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84707027
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.82030044
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.78114945
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77343455
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75018882
35AR_21572438_ChIP-Seq_LNCaP_Human1.74254763
36* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73875489
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72067032
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72039069
39BCAT_22108803_ChIP-Seq_LS180_Human1.70587915
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69950774
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69950774
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69950774
43ELK1_19687146_ChIP-ChIP_HELA_Human1.69769111
44* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69443734
45* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67034218
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66510742
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64765020
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63804582
49STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.61472680
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.59935593
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58115748
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54626937
53* NANOG_16153702_ChIP-ChIP_HESCs_Human1.53917873
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51938579
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.50265733
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49782710
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49427613
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48752908
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46324506
60MYC_18940864_ChIP-ChIP_HL60_Human1.45719918
61* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44365754
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.44095597
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.43978889
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42682275
65SMAD4_21799915_ChIP-Seq_A2780_Human1.41913100
66SMAD3_21741376_ChIP-Seq_HESCs_Human1.39690030
67* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39124514
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.38486767
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37024943
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36724239
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36446214
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36437006
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33857153
74* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33177168
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32970197
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30906943
77ER_23166858_ChIP-Seq_MCF-7_Human1.28331386
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28157365
79* AR_25329375_ChIP-Seq_VCAP_Human1.25026236
80* SMAD4_21741376_ChIP-Seq_HESCs_Human1.24968016
81TCF4_22108803_ChIP-Seq_LS180_Human1.24207038
82* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24017692
83* CBP_20019798_ChIP-Seq_JUKART_Human1.24017692
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22067628
85RNF2_27304074_Chip-Seq_NSC_Mouse1.21620350
86DROSHA_22980978_ChIP-Seq_HELA_Human1.21157882
87FUS_26573619_Chip-Seq_HEK293_Human1.20902676
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.18358293
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.17269524
90STAT3_23295773_ChIP-Seq_U87_Human1.14639661
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13979190
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.13729823
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13426980
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12908299
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11993820
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11993820
97SOX2_19829295_ChIP-Seq_ESCs_Human1.10869066
98NANOG_19829295_ChIP-Seq_ESCs_Human1.10869066
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10841404
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09715623
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08423521
102* RUNX2_22187159_ChIP-Seq_PCA_Human1.08011805
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07707577
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.07347988
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07323931
106* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06522444
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05603096
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.05590452
109SOX9_26525672_Chip-Seq_HEART_Mouse1.05375035
110TCF4_23295773_ChIP-Seq_U87_Human1.04141898
111TRIM28_21343339_ChIP-Seq_HEK293_Human1.02230754
112SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02159205
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.01701056
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01455399
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01330235
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00513250
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00484936
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.00251795
119IRF1_19129219_ChIP-ChIP_H3396_Human0.99743108
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99446772
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98758765
122P300_19829295_ChIP-Seq_ESCs_Human0.98756981
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98417076
124* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96858238
125JUN_21703547_ChIP-Seq_K562_Human0.96480670
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.96096212
127AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95645938
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94863672
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.94034685
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93437858
131CTCF_20526341_ChIP-Seq_ESCs_Human0.92823640
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92673703
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92038740
134* EOMES_21245162_ChIP-Seq_HESCs_Human0.91461194
135TBL1_22424771_ChIP-Seq_293T_Human0.90519209
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90426750
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.90419479
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90185111
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89894798
140CTCF_27219007_Chip-Seq_Bcells_Human0.89340144
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.88293820
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88027361
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87334659
144TP53_18474530_ChIP-ChIP_U2OS_Human0.86252665
145HTT_18923047_ChIP-ChIP_STHdh_Human0.85479830
146PHF8_20622853_ChIP-Seq_HELA_Human0.85479357
147* TP53_20018659_ChIP-ChIP_R1E_Mouse0.84855302
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84584963
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84582590
150GATA6_21074721_ChIP-Seq_CACO-2_Human0.84275457
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83955602
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83096741
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82976698
154EP300_21415370_ChIP-Seq_HL-1_Mouse0.82604955
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82046643
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.80954417
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80902586
158OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80618091
159SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80423914
160P300_18555785_Chip-Seq_ESCs_Mouse0.79807712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.76243091
2MP0004381_abnormal_hair_follicle3.76223581
3MP0003890_abnormal_embryonic-extraembry3.75889809
4MP0002796_impaired_skin_barrier3.56546257
5MP0003880_abnormal_central_pattern3.49231416
6MP0000383_abnormal_hair_follicle3.29852034
7MP0003136_yellow_coat_color3.06490738
8MP0010678_abnormal_skin_adnexa3.04509537
9MP0006292_abnormal_olfactory_placode2.87577186
10MP0003950_abnormal_plasma_membrane2.80522553
11MP0004270_analgesia2.72009635
12MP0001529_abnormal_vocalization2.60719349
13MP0000566_synostosis2.59835391
14MP0005451_abnormal_body_composition2.57753096
15MP0005410_abnormal_fertilization2.45374290
16MP0004742_abnormal_vestibular_system2.44673092
17MP0003119_abnormal_digestive_system2.34612273
18MP0003690_abnormal_glial_cell2.30428326
19MP0003195_calcinosis2.29861507
20MP0002938_white_spotting2.20793459
21MP0000049_abnormal_middle_ear2.12251166
22MP0003329_amyloid_beta_deposits2.09215052
23MP0000647_abnormal_sebaceous_gland2.08387311
24MP0005409_darkened_coat_color2.07689892
25MP0002736_abnormal_nociception_after2.04165635
26MP0004142_abnormal_muscle_tone2.01708996
27MP0001905_abnormal_dopamine_level1.98241875
28MP0002272_abnormal_nervous_system1.94271570
29MP0001346_abnormal_lacrimal_gland1.93836302
30MP0005501_abnormal_skin_physiology1.93191505
31MP0003634_abnormal_glial_cell1.87940356
32MP0004885_abnormal_endolymph1.87553291
33MP0005171_absent_coat_pigmentation1.85436214
34MP0000467_abnormal_esophagus_morphology1.84930095
35MP0000462_abnormal_digestive_system1.84289850
36MP0000778_abnormal_nervous_system1.83974897
37MP0002102_abnormal_ear_morphology1.82299615
38MP0000762_abnormal_tongue_morphology1.81561713
39MP0000631_abnormal_neuroendocrine_gland1.77294416
40MP0001984_abnormal_olfaction1.75397897
41MP0001968_abnormal_touch/_nociception1.74340231
42MP0001293_anophthalmia1.71320394
43MP0001485_abnormal_pinna_reflex1.71149368
44MP0001486_abnormal_startle_reflex1.71039614
45MP0000579_abnormal_nail_morphology1.66112373
46MP0003453_abnormal_keratinocyte_physiol1.65473575
47MP0002098_abnormal_vibrissa_morphology1.65162579
48MP0003632_abnormal_nervous_system1.63749014
49MP0002064_seizures1.59052953
50MP0002160_abnormal_reproductive_system1.58142585
51MP0005423_abnormal_somatic_nervous1.57021146
52MP0008877_abnormal_DNA_methylation1.51888396
53MP0010771_integument_phenotype1.50636469
54MP0004133_heterotaxia1.43878100
55MP0002282_abnormal_trachea_morphology1.42473859
56MP0005394_taste/olfaction_phenotype1.39679370
57MP0005499_abnormal_olfactory_system1.39679370
58MP0003937_abnormal_limbs/digits/tail_de1.37745135
59MP0005367_renal/urinary_system_phenotyp1.37366450
60MP0000516_abnormal_urinary_system1.37366450
61MP0002229_neurodegeneration1.36777399
62MP0001340_abnormal_eyelid_morphology1.35533926
63MP0009046_muscle_twitch1.34687670
64MP0005646_abnormal_pituitary_gland1.32699279
65MP0003942_abnormal_urinary_system1.32501719
66MP0001286_abnormal_eye_development1.32090268
67MP0009053_abnormal_anal_canal1.31394078
68MP0002254_reproductive_system_inflammat1.31352264
69MP0008058_abnormal_DNA_repair1.30652233
70MP0003941_abnormal_skin_development1.30472746
71MP0001216_abnormal_epidermal_layer1.30330466
72MP0001851_eye_inflammation1.30045957
73MP0010094_abnormal_chromosome_stability1.28528020
74MP0008872_abnormal_physiological_respon1.27964731
75MP0003567_abnormal_fetal_cardiomyocyte1.25948004
76MP0001177_atelectasis1.22516205
77MP0002111_abnormal_tail_morphology1.21092755
78MP0002734_abnormal_mechanical_nocicepti1.20957315
79MP0005187_abnormal_penis_morphology1.20191334
80MP0008569_lethality_at_weaning1.19841389
81MP0004145_abnormal_muscle_electrophysio1.18510212
82MP0003938_abnormal_ear_development1.18072450
83MP0008789_abnormal_olfactory_epithelium1.17711751
84MP0000955_abnormal_spinal_cord1.17677398
85MP0000372_irregular_coat_pigmentation1.17172548
86MP0004185_abnormal_adipocyte_glucose1.16676291
87MP0003121_genomic_imprinting1.16157783
88MP0009745_abnormal_behavioral_response1.13673440
89MP0001299_abnormal_eye_distance/1.12820319
90MP0000428_abnormal_craniofacial_morphol1.11214971
91MP0002084_abnormal_developmental_patter1.11153676
92MP0002882_abnormal_neuron_morphology1.10454405
93MP0002751_abnormal_autonomic_nervous1.09527557
94MP0005389_reproductive_system_phenotype1.09502252
95MP0002249_abnormal_larynx_morphology1.08509339
96MP0002752_abnormal_somatic_nervous1.08191462
97MP0000377_abnormal_hair_follicle1.07216896
98MP0009379_abnormal_foot_pigmentation1.05599942
99MP0002184_abnormal_innervation1.05354492
100MP0003631_nervous_system_phenotype1.04096280
101MP0005275_abnormal_skin_tensile1.03395149
102MP0002060_abnormal_skin_morphology1.02292930
103MP0010234_abnormal_vibrissa_follicle1.01434089
104MP0001440_abnormal_grooming_behavior1.01279487
105MP0003935_abnormal_craniofacial_develop1.01094032
106MP0002735_abnormal_chemical_nociception1.01086341
107MP0003718_maternal_effect1.01016204
108MP0003635_abnormal_synaptic_transmissio1.00882966
109MP0004215_abnormal_myocardial_fiber0.99318273
110MP0002932_abnormal_joint_morphology0.98318866
111MP0005551_abnormal_eye_electrophysiolog0.97777375
112MP0006054_spinal_hemorrhage0.97189817
113MP0002116_abnormal_craniofacial_bone0.96247299
114MP0002234_abnormal_pharynx_morphology0.95927124
115MP0008932_abnormal_embryonic_tissue0.94351450
116MP0003122_maternal_imprinting0.94094925
117MP0006072_abnormal_retinal_apoptosis0.94055079
118MP0000427_abnormal_hair_cycle0.92682099
119MP0004957_abnormal_blastocyst_morpholog0.92215005
120MP0005408_hypopigmentation0.90512849
121MP0002085_abnormal_embryonic_tissue0.90251910
122MP0002066_abnormal_motor_capabilities/c0.89288408
123MP0001963_abnormal_hearing_physiology0.89202444
124MP0002638_abnormal_pupillary_reflex0.89041678
125MP0004043_abnormal_pH_regulation0.88881519
126MP0001970_abnormal_pain_threshold0.87821629
127MP0003787_abnormal_imprinting0.87513341
128* MP0002109_abnormal_limb_morphology0.87121882
129MP0000537_abnormal_urethra_morphology0.86759176
130MP0002572_abnormal_emotion/affect_behav0.86752500
131MP0005084_abnormal_gallbladder_morpholo0.85882291
132MP0003936_abnormal_reproductive_system0.85744732
133MP0008995_early_reproductive_senescence0.84864025
134MP0000747_muscle_weakness0.84158304
135MP0010030_abnormal_orbit_morphology0.83663918
136MP0005391_vision/eye_phenotype0.82700002
137MP0004859_abnormal_synaptic_plasticity0.82521769
138MP0002138_abnormal_hepatobiliary_system0.82431918
139MP0002557_abnormal_social/conspecific_i0.79162772
140MP0000432_abnormal_head_morphology0.78872253
141MP0001727_abnormal_embryo_implantation0.78584155
142MP0002067_abnormal_sensory_capabilities0.78371888
143MP0002163_abnormal_gland_morphology0.78036933
144MP0000604_amyloidosis0.77323338
145MP0008260_abnormal_autophagy0.76530993
146MP0002733_abnormal_thermal_nociception0.75900437
147MP0003385_abnormal_body_wall0.75282403
148MP0005195_abnormal_posterior_eye0.75156467
149MP0003806_abnormal_nucleotide_metabolis0.72904082
150MP0000026_abnormal_inner_ear0.72003058
151MP0009250_abnormal_appendicular_skeleto0.71784723
152MP0003755_abnormal_palate_morphology0.71606273
153MP0002152_abnormal_brain_morphology0.70264096
154MP0002233_abnormal_nose_morphology0.69828130
155MP0003698_abnormal_male_reproductive0.69562746
156MP0003011_delayed_dark_adaptation0.68923748
157MP0004134_abnormal_chest_morphology0.68260316
158MP0005253_abnormal_eye_physiology0.67733574
159MP0002063_abnormal_learning/memory/cond0.67629253
160MP0003861_abnormal_nervous_system0.67010818
161MP0003633_abnormal_nervous_system0.66302531
162MP0002177_abnormal_outer_ear0.65260918

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)7.01623376
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.55969089
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.55969089
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.33880909
5Neurofibrillary tangles (HP:0002185)5.28604332
6Sensory axonal neuropathy (HP:0003390)4.64803540
7Congenital ichthyosiform erythroderma (HP:0007431)4.47428139
8Abnormality of the corticospinal tract (HP:0002492)4.21187766
9Peripheral hypomyelination (HP:0007182)4.13378492
10Cerebral hypomyelination (HP:0006808)3.88847819
11Cerebral inclusion bodies (HP:0100314)3.79195783
12True hermaphroditism (HP:0010459)3.53282071
13Alacrima (HP:0000522)3.52732075
14Pancreatic cysts (HP:0001737)3.43040342
15Pancreatic fibrosis (HP:0100732)3.39528546
16Premature skin wrinkling (HP:0100678)3.24757718
17Pendular nystagmus (HP:0012043)3.24523699
18Increased serum pyruvate (HP:0003542)3.18207757
19Abnormality of glycolysis (HP:0004366)3.18207757
20Onion bulb formation (HP:0003383)3.15222536
21Conical tooth (HP:0000698)3.14553048
22Supranuclear gaze palsy (HP:0000605)3.02578252
23Erythroderma (HP:0001019)2.96367773
24Abnormality of the salivary glands (HP:0010286)2.95082713
25Hypotrichosis (HP:0001006)2.89847184
26Leukodystrophy (HP:0002415)2.89075689
27Intention tremor (HP:0002080)2.82855479
28Gonadotropin excess (HP:0000837)2.82592631
29Aplasia involving bones of the upper limbs (HP:0009823)2.80425557
30Aplasia of the phalanges of the hand (HP:0009802)2.80425557
31Aplasia involving bones of the extremities (HP:0009825)2.80425557
32Partial duplication of thumb phalanx (HP:0009944)2.78334218
33Abolished electroretinogram (ERG) (HP:0000550)2.75874501
34Small hand (HP:0200055)2.72723874
35Abnormal auditory evoked potentials (HP:0006958)2.70982372
36Stenosis of the external auditory canal (HP:0000402)2.68422970
37Decreased lacrimation (HP:0000633)2.67487082
38Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.64279470
39Spastic gait (HP:0002064)2.62835272
40Concave nail (HP:0001598)2.58769229
41Akinesia (HP:0002304)2.57382765
42CNS hypomyelination (HP:0003429)2.56958407
43Esophageal atresia (HP:0002032)2.54839886
44Abnormality of midbrain morphology (HP:0002418)2.53001252
45Molar tooth sign on MRI (HP:0002419)2.53001252
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.52370161
47Termporal pattern (HP:0011008)2.51005118
48Insidious onset (HP:0003587)2.51005118
49Thickened helices (HP:0000391)2.48988207
50Abnormality of chromosome stability (HP:0003220)2.48545291
51Split foot (HP:0001839)2.47424834
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.45848399
53Thick nail (HP:0001805)2.44586519
54Partial duplication of the phalanx of hand (HP:0009999)2.42556909
55Dysmetria (HP:0001310)2.42352515
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.42216887
57White forelock (HP:0002211)2.40400223
58Nephronophthisis (HP:0000090)2.38519744
59Furrowed tongue (HP:0000221)2.37968261
60Partial agenesis of the corpus callosum (HP:0001338)2.35905495
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.35469192
62Meckel diverticulum (HP:0002245)2.34262971
63Cupped ear (HP:0000378)2.33629878
64Septate vagina (HP:0001153)2.33575030
65Segmental peripheral demyelination/remyelination (HP:0003481)2.32535627
66Volvulus (HP:0002580)2.31171560
67Conjunctival hamartoma (HP:0100780)2.31032600
68Hyporeflexia of lower limbs (HP:0002600)2.30065569
69Fragile nails (HP:0001808)2.28451712
70Abnormality of the ileum (HP:0001549)2.27351772
71Morphological abnormality of the inner ear (HP:0011390)2.26392110
72Scanning speech (HP:0002168)2.25436175
73Spastic paraparesis (HP:0002313)2.24584989
74Stridor (HP:0010307)2.24300572
75Patchy hypopigmentation of hair (HP:0011365)2.23721351
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22149731
77Coronal craniosynostosis (HP:0004440)2.19102379
78Anencephaly (HP:0002323)2.18422398
79Anteriorly placed anus (HP:0001545)2.16985490
80Bifid tongue (HP:0010297)2.16410510
81Ankle clonus (HP:0011448)2.15878099
82Hypohidrosis (HP:0000966)2.15041274
83Anophthalmia (HP:0000528)2.14876707
84Intestinal atresia (HP:0011100)2.13638083
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.13374458
86Severe visual impairment (HP:0001141)2.13361354
87Methylmalonic aciduria (HP:0012120)2.11551363
88Cystic liver disease (HP:0006706)2.11476800
89Hamartoma of the eye (HP:0010568)2.10490718
90Increased corneal curvature (HP:0100692)2.10341885
91Keratoconus (HP:0000563)2.10341885
92Slow saccadic eye movements (HP:0000514)2.09692011
93Short tibia (HP:0005736)2.09656640
94Short hallux (HP:0010109)2.07692605
95Supernumerary spleens (HP:0009799)2.05963869
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05834602
97Sclerocornea (HP:0000647)2.05806801
98Abnormality of the middle phalanges of the toes (HP:0010183)2.03556063
99Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.02921969
100Abnormality of abdominal situs (HP:0011620)2.02733251
101Abdominal situs inversus (HP:0003363)2.02733251
102Progressive cerebellar ataxia (HP:0002073)2.01493970
103Abnormality of the renal medulla (HP:0100957)1.98755300
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98143702
105Male pseudohermaphroditism (HP:0000037)1.97242128
106Abnormality of the axillary hair (HP:0100134)1.97201328
107Abnormality of secondary sexual hair (HP:0009888)1.97201328
108Humeroradial synostosis (HP:0003041)1.96791943
109Synostosis involving the elbow (HP:0003938)1.96791943
110Hypoplasia of the iris (HP:0007676)1.96428914
111Overfolded helix (HP:0000396)1.95410909
112Corneal erosion (HP:0200020)1.94626211
113Congenital, generalized hypertrichosis (HP:0004540)1.93927795
114Clumsiness (HP:0002312)1.93701089
115Morphological abnormality of the middle ear (HP:0008609)1.93416077
116Preaxial hand polydactyly (HP:0001177)1.92365552
117Abnormality of the labia minora (HP:0012880)1.91658554
118Aplasia/Hypoplasia of the hallux (HP:0008362)1.91051180
119Abnormal pancreas size (HP:0012094)1.91001700
120Oligodactyly (hands) (HP:0001180)1.90378664
121Gastrointestinal atresia (HP:0002589)1.90228299
122Autoamputation (HP:0001218)1.89080374
123Foot dorsiflexor weakness (HP:0009027)1.88918401
124Postaxial foot polydactyly (HP:0001830)1.88039471
125Abnormality of the nasal septum (HP:0000419)1.87827044
126Cutaneous finger syndactyly (HP:0010554)1.87381589
127Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.86532177
128Abnormally folded helix (HP:0008544)1.86280204
129Chorioretinal atrophy (HP:0000533)1.86187774
130Bowel incontinence (HP:0002607)1.85384469
131Abnormality of the proximal phalanges of the hand (HP:0009834)1.85345717
132Methylmalonic acidemia (HP:0002912)1.84626104
133Pterygium (HP:0001059)1.84428286
134Nasolacrimal duct obstruction (HP:0000579)1.83267296
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.82663792
136Absent/shortened dynein arms (HP:0200106)1.82663792
137Abnormality of methionine metabolism (HP:0010901)1.82052485
138Lip pit (HP:0100267)1.80817722
139Myelomeningocele (HP:0002475)1.79778602
140Renal hypoplasia (HP:0000089)1.79392987
141Hepatosplenomegaly (HP:0001433)1.78847074
142Milia (HP:0001056)1.78729594
143Hypomagnesemia (HP:0002917)1.78677121
144Abnormality of the foot musculature (HP:0001436)1.77499430
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77338259
146Myokymia (HP:0002411)1.76803792
147Decreased motor nerve conduction velocity (HP:0003431)1.76530776
148Decreased central vision (HP:0007663)1.76517529
149Medial flaring of the eyebrow (HP:0010747)1.76451818
150Abnormal rod and cone electroretinograms (HP:0008323)1.76192095
151Abnormality of the 2nd finger (HP:0004100)1.76072781
152Retinal dysplasia (HP:0007973)1.75722817
153Increased circulating renin level (HP:0000848)1.75052953
154Anomalous pulmonary venous return (HP:0010772)1.74997995
155Muscle fiber splitting (HP:0003555)1.74493206
156Cerebral hemorrhage (HP:0001342)1.73349131
157Chronic hepatic failure (HP:0100626)1.72263234
158Absent radius (HP:0003974)1.71973873
159Dandy-Walker malformation (HP:0001305)1.71807059
160Abnormal large intestine physiology (HP:0012700)1.70982662
161Genetic anticipation (HP:0003743)1.70865764
162Bilateral microphthalmos (HP:0007633)1.70813418
163Anhidrosis (HP:0000970)1.70658467
164Ridged nail (HP:0001807)1.70491970
165Morphological abnormality of the pyramidal tract (HP:0002062)1.70067671
166Postaxial hand polydactyly (HP:0001162)1.69845011
167Confusion (HP:0001289)1.69824503
168Seborrheic dermatitis (HP:0001051)1.69552631
169Ectopic kidney (HP:0000086)1.69463420
170Brittle hair (HP:0002299)1.69125522
171Abnormality of the preputium (HP:0100587)1.68769081
172* Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65660703
173Meningioma (HP:0002858)1.65122614
174Periauricular skin pits (HP:0100277)1.64995111
175Preauricular pit (HP:0004467)1.64995111
176Sloping forehead (HP:0000340)1.64937770
177Labial hypoplasia (HP:0000066)1.64800731
178Absent forearm bone (HP:0003953)1.64438923
179Aplasia involving forearm bones (HP:0009822)1.64438923
180Synostosis of carpal bones (HP:0005048)1.63901202
181Short 1st metacarpal (HP:0010034)1.63579576
182Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63579576
183Mesomelia (HP:0003027)1.62228997
184Colon cancer (HP:0003003)1.61753820
185Megalencephaly (HP:0001355)1.61665123
186Hemivertebrae (HP:0002937)1.61619139
187Hypoplastic female external genitalia (HP:0012815)1.60224369
188Congenital hepatic fibrosis (HP:0002612)1.60009761
189Median cleft lip (HP:0000161)1.59160724
190Oligohydramnios (HP:0001562)1.59025340
191Long nose (HP:0003189)1.58759606
192Triphalangeal thumb (HP:0001199)1.58322530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.98166670
2OXSR14.27261337
3WNK33.65304180
4BCR3.33755281
5EPHB12.97024171
6ACVR1B2.78409707
7MST42.71646921
8MET2.71190856
9PBK2.69808856
10PKN12.68777354
11FRK2.66764623
12MKNK22.56861838
13TRIM282.55114012
14FGFR22.50836475
15MAPKAPK52.45482800
16CDK192.42549136
17PLK42.40878625
18TNIK2.24195304
19NUAK12.16375410
20LIMK12.03853404
21WNK41.96130782
22WEE11.93518554
23PLK21.90547576
24UHMK11.84898995
25CSNK1G31.83977705
26PNCK1.73739461
27MAP4K21.70496778
28PLK31.69509630
29CASK1.66477014
30CSNK1A1L1.65783609
31VRK21.63731299
32MAP3K41.63373192
33ADRBK21.61864492
34TESK21.58371862
35BRSK21.58074080
36ROCK21.56280917
37CAMK2B1.51967479
38ERBB31.49477164
39TAF11.49195282
40CLK11.47956277
41WNK11.47819253
42PRPF4B1.45867326
43EIF2AK31.40798052
44CSNK1G11.38224415
45PINK11.35681171
46NEK61.33515947
47CDC71.30658351
48NTRK11.28741468
49ICK1.27527635
50ZAK1.25483488
51DYRK21.25143372
52CAMK2D1.24577923
53STK161.24023863
54CSNK1G21.23878783
55SRPK11.23856497
56VRK11.20847049
57TYRO31.19930786
58BMPR1B1.18179196
59MST1R1.05602038
60FGR1.04983324
61EIF2AK11.01162734
62PLK10.98896045
63MAP3K20.98660741
64MAPK150.98559171
65STK38L0.95948384
66MARK10.94618240
67CAMK2G0.93750617
68TRPM70.93736132
69MAP2K20.93494315
70PAK60.91251220
71TTK0.88621902
72MARK20.88070249
73NTRK20.87521277
74PRKCG0.86540479
75NEK20.86393808
76BRSK10.85351135
77NEK10.84286016
78FGFR10.83014214
79TGFBR10.81262106
80CDK140.80992802
81GRK70.80044060
82RPS6KA50.78752022
83MAP2K70.78543510
84STK30.78293303
85INSRR0.76268934
86CAMK2A0.76089662
87EPHA40.73826294
88ARAF0.71711637
89ADRBK10.68651390
90PRKD10.68020940
91CDK150.67678155
92BUB10.66282897
93EPHB20.66213302
94TESK10.65647852
95NLK0.65474600
96IRAK20.64584843
97SGK4940.64408888
98SGK2230.64408888
99CSNK1D0.63598586
100PRKCQ0.63295796
101CDK50.62644188
102TSSK60.62476816
103CDK180.62364124
104PRKCE0.62074178
105PAK30.61663253
106CDK11A0.61466613
107EIF2AK20.60716351
108CCNB10.55334110
109STK110.54733969
110MINK10.54554824
111PAK10.54514299
112ATR0.52603141
113ERBB20.50609675
114AKT30.50271606
115KSR20.48474546
116CHEK20.46659692
117GSK3A0.46204663
118MKNK10.44669942
119BRD40.44511541
120ERBB40.44185969
121ATM0.43909174
122ITK0.43581751
123PHKG20.43192035
124PHKG10.43192035
125FYN0.43179709
126CSNK1E0.43075049
127PRKD20.42136953
128PDK20.41507115
129MAP3K120.41411220
130MELK0.40551217
131MAP3K90.40519122
132NME10.40189767
133PRKG10.40019657
134PDPK10.39884242
135IRAK10.38928254
136FLT30.38415302
137CSNK1A10.38109453
138EPHA20.36312103
139MOS0.36282633
140FER0.36042856
141AURKB0.35582355
142STK100.33680947
143MAP3K30.33479188
144CHEK10.32833332
145PRKACB0.31820438
146DMPK0.31275536
147PTK2B0.30905620
148CSNK2A10.30674476
149TLK10.29520351
150MAPK130.29287992
151ROCK10.28908963
152DAPK30.28274803
153IGF1R0.28269264
154GRK50.26584922
155SGK20.25965099
156CDK30.25844377
157YES10.25749607
158PRKACA0.25281169
159PAK20.24071934
160GRK10.23262305
161MAP3K130.23050911
162LATS20.22247411
163MUSK0.21669154

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.90697436
2Steroid biosynthesis_Homo sapiens_hsa001005.05075715
3Fatty acid elongation_Homo sapiens_hsa000624.50380789
4Ether lipid metabolism_Homo sapiens_hsa005653.23054033
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.99297639
6Homologous recombination_Homo sapiens_hsa034402.90774194
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.82691055
8Oxidative phosphorylation_Homo sapiens_hsa001902.56218945
9Sphingolipid metabolism_Homo sapiens_hsa006002.35683257
10Fanconi anemia pathway_Homo sapiens_hsa034602.23744634
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21680002
12Basal transcription factors_Homo sapiens_hsa030222.15174733
13Linoleic acid metabolism_Homo sapiens_hsa005912.12955997
14Axon guidance_Homo sapiens_hsa043602.00248003
15Non-homologous end-joining_Homo sapiens_hsa034501.94571556
16Propanoate metabolism_Homo sapiens_hsa006401.88052828
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87638958
18Histidine metabolism_Homo sapiens_hsa003401.87030948
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83238651
20Mismatch repair_Homo sapiens_hsa034301.82729624
21Protein export_Homo sapiens_hsa030601.80454190
22Parkinsons disease_Homo sapiens_hsa050121.70766799
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65402760
24Alzheimers disease_Homo sapiens_hsa050101.61930317
25Sulfur metabolism_Homo sapiens_hsa009201.57718194
26Nucleotide excision repair_Homo sapiens_hsa034201.52922434
27RNA degradation_Homo sapiens_hsa030181.44943138
28Arachidonic acid metabolism_Homo sapiens_hsa005901.42121592
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39798904
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37443169
31DNA replication_Homo sapiens_hsa030301.35517843
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35095847
33RNA transport_Homo sapiens_hsa030131.30420218
34Ribosome_Homo sapiens_hsa030101.27660056
35Serotonergic synapse_Homo sapiens_hsa047261.27519325
36Caffeine metabolism_Homo sapiens_hsa002321.26121414
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.24988729
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23203409
39Tight junction_Homo sapiens_hsa045301.22917984
40TGF-beta signaling pathway_Homo sapiens_hsa043501.21897374
41Collecting duct acid secretion_Homo sapiens_hsa049661.20421648
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19462189
43Pyruvate metabolism_Homo sapiens_hsa006201.18843695
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12988662
45* Hedgehog signaling pathway_Homo sapiens_hsa043401.12764926
46Vitamin B6 metabolism_Homo sapiens_hsa007501.08935006
47Glutamatergic synapse_Homo sapiens_hsa047241.07096099
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04770244
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04763784
50Vibrio cholerae infection_Homo sapiens_hsa051101.04552037
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03362381
52* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02707923
53Huntingtons disease_Homo sapiens_hsa050161.01473487
54Butanoate metabolism_Homo sapiens_hsa006500.99230746
55Long-term depression_Homo sapiens_hsa047300.98662297
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97908573
57Melanoma_Homo sapiens_hsa052180.97027917
58Cardiac muscle contraction_Homo sapiens_hsa042600.95316210
59Glutathione metabolism_Homo sapiens_hsa004800.91850521
60* Basal cell carcinoma_Homo sapiens_hsa052170.90384079
61Base excision repair_Homo sapiens_hsa034100.90348177
62One carbon pool by folate_Homo sapiens_hsa006700.89731606
63Arginine and proline metabolism_Homo sapiens_hsa003300.89124323
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88834519
65Spliceosome_Homo sapiens_hsa030400.88727363
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88302455
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.88231504
68Olfactory transduction_Homo sapiens_hsa047400.87465421
69Renal cell carcinoma_Homo sapiens_hsa052110.86816449
70Cell cycle_Homo sapiens_hsa041100.86708808
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.85297980
72Tryptophan metabolism_Homo sapiens_hsa003800.84777566
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81740777
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81402929
75GABAergic synapse_Homo sapiens_hsa047270.79440034
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79232628
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.76658179
78Oocyte meiosis_Homo sapiens_hsa041140.76631707
79Phototransduction_Homo sapiens_hsa047440.75946200
80Selenocompound metabolism_Homo sapiens_hsa004500.75527272
81Ras signaling pathway_Homo sapiens_hsa040140.74904966
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.72827688
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72167399
84RNA polymerase_Homo sapiens_hsa030200.71334226
85Cocaine addiction_Homo sapiens_hsa050300.70827803
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69831141
87Fat digestion and absorption_Homo sapiens_hsa049750.68877997
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68214413
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64567724
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63685292
91Endocytosis_Homo sapiens_hsa041440.63559708
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.61966992
93Fatty acid biosynthesis_Homo sapiens_hsa000610.61794322
94Rheumatoid arthritis_Homo sapiens_hsa053230.59807177
95p53 signaling pathway_Homo sapiens_hsa041150.59062458
96Mineral absorption_Homo sapiens_hsa049780.58683695
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58001772
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57352192
99Fatty acid degradation_Homo sapiens_hsa000710.57099562
100Tyrosine metabolism_Homo sapiens_hsa003500.56945635
101Retinol metabolism_Homo sapiens_hsa008300.56806844
102Fatty acid metabolism_Homo sapiens_hsa012120.56592755
103Dorso-ventral axis formation_Homo sapiens_hsa043200.54900077
104Purine metabolism_Homo sapiens_hsa002300.54201822
105Pancreatic secretion_Homo sapiens_hsa049720.53464711
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53455293
107Ovarian steroidogenesis_Homo sapiens_hsa049130.51232918
108Insulin secretion_Homo sapiens_hsa049110.51138852
109Glycerolipid metabolism_Homo sapiens_hsa005610.50995572
110Chemical carcinogenesis_Homo sapiens_hsa052040.50484060
111Folate biosynthesis_Homo sapiens_hsa007900.49315536
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.48819797
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.48765164
114Morphine addiction_Homo sapiens_hsa050320.47427335
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47306326
116* Hippo signaling pathway_Homo sapiens_hsa043900.45885393
117Salivary secretion_Homo sapiens_hsa049700.45661283
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.45573074
119Metabolic pathways_Homo sapiens_hsa011000.43382019
120Phenylalanine metabolism_Homo sapiens_hsa003600.42993095
121Pyrimidine metabolism_Homo sapiens_hsa002400.42778685
122Nitrogen metabolism_Homo sapiens_hsa009100.42119564
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41693661
124ErbB signaling pathway_Homo sapiens_hsa040120.41483608
125beta-Alanine metabolism_Homo sapiens_hsa004100.40898732
126ECM-receptor interaction_Homo sapiens_hsa045120.40846859
127Nicotine addiction_Homo sapiens_hsa050330.40746122
128Phagosome_Homo sapiens_hsa041450.40512951
129Renin secretion_Homo sapiens_hsa049240.40458835
130* Wnt signaling pathway_Homo sapiens_hsa043100.40392952
131Synaptic vesicle cycle_Homo sapiens_hsa047210.38087254
132Dopaminergic synapse_Homo sapiens_hsa047280.37200380
133Circadian entrainment_Homo sapiens_hsa047130.37007503
134Taste transduction_Homo sapiens_hsa047420.35672032
135* Melanogenesis_Homo sapiens_hsa049160.34879672
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33943073
137Gastric acid secretion_Homo sapiens_hsa049710.33364978
138Cholinergic synapse_Homo sapiens_hsa047250.33075153
139Gap junction_Homo sapiens_hsa045400.32464673
140MAPK signaling pathway_Homo sapiens_hsa040100.26641477
141Alcoholism_Homo sapiens_hsa050340.26389733
142Autoimmune thyroid disease_Homo sapiens_hsa053200.26037399
143Peroxisome_Homo sapiens_hsa041460.24892650
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24150382
145Proteasome_Homo sapiens_hsa030500.24007812
146Vitamin digestion and absorption_Homo sapiens_hsa049770.23162482
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21327839
148Amphetamine addiction_Homo sapiens_hsa050310.20512254

Most similar genes based on co-expression Upload to Enrichr

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