WNT3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hematopoietic stem cell proliferation (GO:0071425)8.03547947
2* spinal cord association neuron differentiation (GO:0021527)7.48488646
3hemidesmosome assembly (GO:0031581)7.18628512
4regulation of histone H3-K27 methylation (GO:0061085)6.69653837
5desmosome organization (GO:0002934)6.44962725
6cornea development in camera-type eye (GO:0061303)6.14913116
7regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.14221558
8midbrain development (GO:0030901)5.90720091
9labyrinthine layer development (GO:0060711)5.79123878
10intestinal epithelial cell development (GO:0060576)5.72162491
11keratinocyte development (GO:0003334)5.51070036
12cardiac right ventricle morphogenesis (GO:0003215)5.49358907
13planar cell polarity pathway involved in neural tube closure (GO:0090179)5.43466422
14regulation of water loss via skin (GO:0033561)5.41810556
15establishment of skin barrier (GO:0061436)5.39073530
16lung-associated mesenchyme development (GO:0060484)5.31140779
17folic acid metabolic process (GO:0046655)5.15484836
18regulation of cell proliferation involved in kidney development (GO:1901722)5.04954700
19folic acid transport (GO:0015884)5.03691371
20cellular response to interferon-alpha (GO:0035457)5.02101893
21negative regulation of cell aging (GO:0090344)4.97461939
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.94366538
23neuron fate determination (GO:0048664)4.93394697
24myoblast fusion (GO:0007520)4.78392482
25hepatocyte differentiation (GO:0070365)4.77392926
26maturation of SSU-rRNA (GO:0030490)4.71408213
27cranial suture morphogenesis (GO:0060363)4.60972548
28mesenchymal-epithelial cell signaling (GO:0060638)4.58987225
29outflow tract septum morphogenesis (GO:0003148)4.56279474
30cyclooxygenase pathway (GO:0019371)4.56276462
31regulation of hair follicle development (GO:0051797)4.50884813
32trophectodermal cell differentiation (GO:0001829)4.50167958
33regulation of interleukin-13 production (GO:0032656)4.44856817
34* positive regulation of embryonic development (GO:0040019)4.42418831
35positive regulation of transcription regulatory region DNA binding (GO:2000679)4.41383802
36ribosomal small subunit biogenesis (GO:0042274)4.35782717
37respiratory tube development (GO:0030323)4.32938849
38syncytium formation by plasma membrane fusion (GO:0000768)4.31194240
39peptidyl-arginine omega-N-methylation (GO:0035247)4.29836134
40ear development (GO:0043583)4.29077169
41viral transcription (GO:0019083)4.18819475
42bone trabecula formation (GO:0060346)4.16153236
43convergent extension (GO:0060026)4.12583153
44ribosomal large subunit biogenesis (GO:0042273)4.10319101
45translational termination (GO:0006415)4.08084729
46mesenchymal to epithelial transition (GO:0060231)4.02870051
47regulation of mammary gland epithelial cell proliferation (GO:0033599)4.01852994
48multicellular organismal water homeostasis (GO:0050891)4.00511723
49prostanoid biosynthetic process (GO:0046457)3.96741497
50prostaglandin biosynthetic process (GO:0001516)3.96741497
51organ induction (GO:0001759)3.86825030
52establishment of tissue polarity (GO:0007164)3.83554848
53establishment of planar polarity (GO:0001736)3.83554848
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.82811630
55morphogenesis of an epithelial fold (GO:0060571)3.82159884
56stem cell proliferation (GO:0072089)3.82049396
57positive regulation of hair follicle development (GO:0051798)3.78180804
58positive regulation of hair cycle (GO:0042635)3.78180804
59embryonic skeletal joint morphogenesis (GO:0060272)3.75798567
60histone arginine methylation (GO:0034969)3.75159931
61mesonephros development (GO:0001823)3.71730405
62syncytium formation (GO:0006949)3.70014356
63formation of translation preinitiation complex (GO:0001731)3.68946084
64left/right pattern formation (GO:0060972)3.65977346
65negative regulation of interleukin-2 production (GO:0032703)3.65829733
66branching involved in salivary gland morphogenesis (GO:0060445)3.64527876
67outer ear morphogenesis (GO:0042473)3.62633124
68establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.61007732
69peptidyl-arginine N-methylation (GO:0035246)3.60275601
70peptidyl-arginine methylation (GO:0018216)3.60275601
71regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.59956830
72regulation of establishment of planar polarity (GO:0090175)3.59909735
73translational elongation (GO:0006414)3.56874068
74water homeostasis (GO:0030104)3.56592532
75forebrain morphogenesis (GO:0048853)3.55497097
76response to xenobiotic stimulus (GO:0009410)3.55056063
77mesenchymal cell proliferation (GO:0010463)3.54775182
78modified amino acid transport (GO:0072337)3.54396268
79negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.52635239
80translational initiation (GO:0006413)3.50946175
81paraxial mesoderm development (GO:0048339)3.47861538
82norepinephrine metabolic process (GO:0042415)3.43125131
83* positive regulation of canonical Wnt signaling pathway (GO:0090263)3.41151854
84surfactant homeostasis (GO:0043129)3.40392832
85* dorsal/ventral neural tube patterning (GO:0021904)3.40208672
86wound healing, spreading of epidermal cells (GO:0035313)3.36831693
87non-canonical Wnt signaling pathway (GO:0035567)3.35934954
88epithelial cell differentiation involved in prostate gland development (GO:0060742)3.34056674
89prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.30370940
90notochord development (GO:0030903)3.29492610
91establishment or maintenance of apical/basal cell polarity (GO:0035088)3.29112328
92establishment or maintenance of bipolar cell polarity (GO:0061245)3.29112328
93craniofacial suture morphogenesis (GO:0097094)3.26291557
94muscle cell fate commitment (GO:0042693)3.25875797
95amino sugar catabolic process (GO:0046348)3.25865228
96lymph vessel development (GO:0001945)3.25705303
97* canonical Wnt signaling pathway (GO:0060070)3.24549380
98anterior/posterior axis specification, embryo (GO:0008595)3.24415236
99DNA deamination (GO:0045006)3.24161673
100regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.23048945
101response to nitric oxide (GO:0071731)3.22615686
102positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.22352468
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20049912
104SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19532576
105embryonic body morphogenesis (GO:0010172)3.18884834
106viral life cycle (GO:0019058)3.18211843
107positive regulation of hormone metabolic process (GO:0032352)3.17724565
108cellular protein complex disassembly (GO:0043624)3.16885555
109* cell surface receptor signaling pathway involved in heart development (GO:0061311)3.16440772
110protein targeting to ER (GO:0045047)3.12040275
111cotranslational protein targeting to membrane (GO:0006613)3.11927091
112mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.11838257
113regulation of organ formation (GO:0003156)3.09277954
114establishment of apical/basal cell polarity (GO:0035089)3.09173529
115gland morphogenesis (GO:0022612)3.08636912
116regulation of interleukin-5 production (GO:0032674)3.07884706
117neuron projection extension involved in neuron projection guidance (GO:1902284)3.07533806
118axon extension involved in axon guidance (GO:0048846)3.07533806
119endocrine hormone secretion (GO:0060986)3.06229338
120ribosomal small subunit assembly (GO:0000028)3.05157015
121sympathetic nervous system development (GO:0048485)3.04773197
122dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.04543122
123lens fiber cell development (GO:0070307)3.02564988
124mammary gland epithelial cell differentiation (GO:0060644)3.02227159
125proteasome assembly (GO:0043248)3.02139098
126negative regulation of kidney development (GO:0090185)3.01327100
127ventricular septum development (GO:0003281)3.01152425
128body morphogenesis (GO:0010171)2.99119054
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97553471
130positive regulation of mesonephros development (GO:0061213)2.97517278
131apical protein localization (GO:0045176)2.97314514
132negative regulation of epidermis development (GO:0045683)2.96431848
133protein localization to endoplasmic reticulum (GO:0070972)2.94838151
134amyloid precursor protein catabolic process (GO:0042987)2.94649158
135establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93958622
136* cell differentiation in spinal cord (GO:0021515)2.93663817
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92013767
138positive regulation of interleukin-4 production (GO:0032753)2.91635410
139lens development in camera-type eye (GO:0002088)2.91179666
140calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.91004244
141ribonucleoprotein complex biogenesis (GO:0022613)2.90224105
142digestive tract morphogenesis (GO:0048546)2.89908857
143cochlea morphogenesis (GO:0090103)2.89561473
144prostaglandin metabolic process (GO:0006693)2.88995081
145prostanoid metabolic process (GO:0006692)2.88995081
146regulation of cellular amino acid metabolic process (GO:0006521)2.88822400
147ribosome assembly (GO:0042255)2.88642032
148tooth mineralization (GO:0034505)2.88104283
149positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86753522
150purine nucleobase biosynthetic process (GO:0009113)2.85961319
151regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.85869065
152positive regulation of lamellipodium assembly (GO:0010592)2.85788854
153regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84703874
154atrial septum morphogenesis (GO:0060413)2.82698400
155wound healing, spreading of cells (GO:0044319)2.82239828
156cranial nerve morphogenesis (GO:0021602)2.82218443
157* inner ear morphogenesis (GO:0042472)2.79761507
158protein complex disassembly (GO:0043241)2.78741481
159bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77077724
160apoptotic process involved in morphogenesis (GO:0060561)2.77020693
161uterus development (GO:0060065)2.76539675
162limb bud formation (GO:0060174)2.75061621
163rRNA transcription (GO:0009303)2.74622896
164lateral sprouting from an epithelium (GO:0060601)2.73970453
165embryonic viscerocranium morphogenesis (GO:0048703)2.73810874
166keratinization (GO:0031424)2.73722383
167mesoderm formation (GO:0001707)2.72608094
168positive regulation of pseudopodium assembly (GO:0031274)2.72428463
169heterochromatin organization (GO:0070828)2.72200892
170nucleobase biosynthetic process (GO:0046112)2.71043561
171L-serine metabolic process (GO:0006563)2.70495316
172UTP biosynthetic process (GO:0006228)2.70490273
173regulation of mesonephros development (GO:0061217)2.69385515
174establishment of monopolar cell polarity (GO:0061162)2.69300745
175establishment or maintenance of monopolar cell polarity (GO:0061339)2.69300745
176negative regulation of keratinocyte proliferation (GO:0010839)2.69253100
177negative regulation of Ras GTPase activity (GO:0034261)2.68646866
178regulation of hair cycle (GO:0042634)2.68142698
179negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66968155
180negative regulation of ligase activity (GO:0051352)2.66968155
181developmental induction (GO:0031128)2.66950189
182polarized epithelial cell differentiation (GO:0030859)2.64815661
183regulation of gene silencing by miRNA (GO:0060964)2.64705954
184regulation of gene silencing by RNA (GO:0060966)2.64705954
185regulation of posttranscriptional gene silencing (GO:0060147)2.64705954
186molting cycle (GO:0042303)2.64242155
187mitotic G1 DNA damage checkpoint (GO:0031571)2.64191733
188* regulation of cardioblast differentiation (GO:0051890)2.64056570
189regulation of cell aging (GO:0090342)2.64046932
190embryonic retina morphogenesis in camera-type eye (GO:0060059)2.63871174
191interferon-gamma secretion (GO:0072643)12.6798335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.07568091
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.33919730
3ZNF263_19887448_ChIP-Seq_K562_Human2.94963564
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.84604070
5NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75356857
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67479791
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.58009478
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.53757366
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49473030
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42284743
11TCF3_18692474_ChIP-Seq_MEFs_Mouse2.31532010
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23738505
13KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.23039796
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.20011315
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14454245
16E2F7_22180533_ChIP-Seq_HELA_Human2.14113539
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06610897
18CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.06003087
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.05188950
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.02119595
21TP63_17297297_ChIP-ChIP_HaCaT_Human10.4558996
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95132328
23* LXR_22292898_ChIP-Seq_THP-1_Human1.90751515
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88722501
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88722501
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88722501
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.87647364
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87547014
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86958188
30AR_21909140_ChIP-Seq_LNCAP_Human1.85657146
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83562915
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83329194
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.81349179
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78977674
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74830111
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.71987390
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71800314
38VDR_21846776_ChIP-Seq_THP-1_Human1.71796192
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.71009045
40* EZH2_27304074_Chip-Seq_ESCs_Mouse1.69939759
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.67447957
42* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63857832
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63197635
44KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.63014382
45* EED_16625203_ChIP-ChIP_MESCs_Mouse1.61470594
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58830413
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57170681
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56713406
49EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.56363739
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55798232
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55588626
52ATF3_27146783_Chip-Seq_COLON_Human1.55367362
53OCT4_18692474_ChIP-Seq_MEFs_Mouse1.54875938
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52695619
55KDM2B_26808549_Chip-Seq_K562_Human1.52258744
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48985273
57SOX2_18692474_ChIP-Seq_MEFs_Mouse1.47498229
58XRN2_22483619_ChIP-Seq_HELA_Human1.47265097
59RACK7_27058665_Chip-Seq_MCF-7_Human1.47103229
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46778430
61P68_20966046_ChIP-Seq_HELA_Human1.44723355
62NANOG_18692474_ChIP-Seq_MEFs_Mouse1.44679854
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41319062
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40747870
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39924284
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.38399648
67* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38109011
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37032823
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35782893
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35685806
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35685806
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35622768
73* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34222736
74* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34222736
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.33425460
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.33046140
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32467502
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31575582
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31522995
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31376850
81* RNF2_27304074_Chip-Seq_ESCs_Mouse1.31135497
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29430074
83* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29344579
84GABP_19822575_ChIP-Seq_HepG2_Human1.27898063
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27506880
86* CTCF_27219007_Chip-Seq_Bcells_Human1.27355826
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27347243
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.26929055
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.26316083
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25568968
91* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25177462
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24944775
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24730480
94CREB1_26743006_Chip-Seq_LNCaP_Human1.24352872
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23539934
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.22789108
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21432222
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20907929
99JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20857593
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20795012
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.20553365
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19286319
103FOXP1_21924763_ChIP-Seq_HESCs_Human1.19009084
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18986252
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18688646
106* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18002643
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17426661
108MYC_22102868_ChIP-Seq_BL_Human1.16904000
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16812020
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15789759
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14767896
112CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14704477
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13556289
114* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13452287
115* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13155257
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12461745
117RARA_24833708_ChIP-Seq_LIVER_Mouse1.12441707
118KDM2B_26808549_Chip-Seq_DND41_Human1.12405737
119* EZH2_27294783_Chip-Seq_ESCs_Mouse1.11965363
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.09961322
121KDM5A_27292631_Chip-Seq_BREAST_Human1.09759341
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.08259866
123SMC4_20622854_ChIP-Seq_HELA_Human1.07694850
124ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07607123
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07374782
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07170591
127E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07101377
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07080467
129STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07000687
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06439640
131GABP_17652178_ChIP-ChIP_JURKAT_Human1.06263635
132TTF2_22483619_ChIP-Seq_HELA_Human1.03930816
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.03831097
134SALL1_21062744_ChIP-ChIP_HESCs_Human1.02156698
135NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01203383
136POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99808627
137KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99405744
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98972547
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.97093095
140NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96430410
141* SA1_27219007_Chip-Seq_ERYTHROID_Human0.96115569
142TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96010957
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95921393
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95055351
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93473571
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.91839100
147CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91542960
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.91351434
149POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90306160
150SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90257556
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.89950677
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89540394
153* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87964762
154GATA4_25053715_ChIP-Seq_YYC3_Human0.87964293
155* TP53_20018659_ChIP-ChIP_R1E_Mouse0.85895950
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85205532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000383_abnormal_hair_follicle4.61866269
2MP0002249_abnormal_larynx_morphology4.22066890
3MP0002796_impaired_skin_barrier4.03944087
4MP0010678_abnormal_skin_adnexa3.77461607
5MP0002254_reproductive_system_inflammat3.74090409
6MP0009840_abnormal_foam_cell3.70532970
7MP0003693_abnormal_embryo_hatching3.39733013
8MP0003195_calcinosis3.31754899
9MP0004381_abnormal_hair_follicle3.20484901
10MP0010234_abnormal_vibrissa_follicle3.12962887
11MP0004782_abnormal_surfactant_physiolog3.03135314
12MP0005076_abnormal_cell_differentiation3.03073553
13MP0010352_gastrointestinal_tract_polyps2.98854443
14MP0002098_abnormal_vibrissa_morphology2.73945215
15MP0000049_abnormal_middle_ear2.70075901
16MP0000647_abnormal_sebaceous_gland2.51119099
17MP0000537_abnormal_urethra_morphology2.47316041
18MP0004957_abnormal_blastocyst_morpholog2.46551368
19MP0010030_abnormal_orbit_morphology2.46087550
20MP0002938_white_spotting2.44099126
21MP0003111_abnormal_nucleus_morphology2.24705635
22MP0003941_abnormal_skin_development2.22783854
23MP0000762_abnormal_tongue_morphology2.16200666
24MP0005501_abnormal_skin_physiology2.08312023
25MP0003315_abnormal_perineum_morphology2.05357488
26MP0003705_abnormal_hypodermis_morpholog1.99801444
27MP0001293_anophthalmia1.99387490
28MP0003828_pulmonary_edema1.99114826
29MP0001216_abnormal_epidermal_layer1.96132324
30MP0002060_abnormal_skin_morphology1.94831898
31MP0000579_abnormal_nail_morphology1.85830219
32MP0008995_early_reproductive_senescence1.85258094
33MP0000377_abnormal_hair_follicle1.83964712
34MP0005248_abnormal_Harderian_gland1.81938276
35MP0002233_abnormal_nose_morphology1.80488804
36MP0003786_premature_aging1.79127663
37MP0002697_abnormal_eye_size1.77793043
38MP0001346_abnormal_lacrimal_gland1.72572964
39MP0000566_synostosis1.66822112
40MP0000467_abnormal_esophagus_morphology1.61444660
41MP0006292_abnormal_olfactory_placode1.60933000
42MP0005075_abnormal_melanosome_morpholog1.59122728
43MP0005275_abnormal_skin_tensile1.54686503
44MP0005023_abnormal_wound_healing1.54524453
45MP0005171_absent_coat_pigmentation1.53992545
46MP0000428_abnormal_craniofacial_morphol1.52455214
47MP0003566_abnormal_cell_adhesion1.52050175
48MP0002009_preneoplasia1.48664066
49MP0002092_abnormal_eye_morphology1.48534246
50MP0002932_abnormal_joint_morphology1.44091233
51MP0004858_abnormal_nervous_system1.43979633
52MP0009053_abnormal_anal_canal1.42991694
53MP0000627_abnormal_mammary_gland1.42572759
54MP0003385_abnormal_body_wall1.30375135
55MP0010771_integument_phenotype1.29846691
56MP0008932_abnormal_embryonic_tissue1.29380196
57MP0002116_abnormal_craniofacial_bone1.28796846
58MP0004742_abnormal_vestibular_system1.27855127
59MP0005499_abnormal_olfactory_system1.27215984
60MP0005394_taste/olfaction_phenotype1.27215984
61MP0003077_abnormal_cell_cycle1.25459456
62MP0002089_abnormal_postnatal_growth/wei1.25235595
63MP0000427_abnormal_hair_cycle1.24345882
64* MP0003861_abnormal_nervous_system1.24201865
65MP0008789_abnormal_olfactory_epithelium1.23166628
66MP0003119_abnormal_digestive_system1.20550359
67MP0000026_abnormal_inner_ear1.19748759
68MP0003453_abnormal_keratinocyte_physiol1.18368632
69MP0009379_abnormal_foot_pigmentation1.16622952
70MP0009672_abnormal_birth_weight1.15564078
71MP0003567_abnormal_fetal_cardiomyocyte1.13553935
72MP0001730_embryonic_growth_arrest1.12774168
73* MP0003937_abnormal_limbs/digits/tail_de1.12372069
74MP0003938_abnormal_ear_development1.10872745
75MP0003935_abnormal_craniofacial_develop1.08488996
76MP0009931_abnormal_skin_appearance1.05203079
77MP0000733_abnormal_muscle_development1.05057742
78MP0003755_abnormal_palate_morphology1.04340622
79MP0000462_abnormal_digestive_system1.03712504
80MP0003123_paternal_imprinting1.00943797
81MP0000003_abnormal_adipose_tissue0.97790352
82MP0003115_abnormal_respiratory_system0.95966920
83MP0001727_abnormal_embryo_implantation0.95124798
84MP0002234_abnormal_pharynx_morphology0.94256521
85MP0003936_abnormal_reproductive_system0.94241630
86MP0001849_ear_inflammation0.93873862
87MP0002086_abnormal_extraembryonic_tissu0.93520726
88MP0004019_abnormal_vitamin_homeostasis0.92153352
89MP0005377_hearing/vestibular/ear_phenot0.92088337
90MP0003878_abnormal_ear_physiology0.92088337
91MP0005380_embryogenesis_phenotype0.91435274
92MP0001672_abnormal_embryogenesis/_devel0.91435274
93MP0001340_abnormal_eyelid_morphology0.90363297
94MP0001286_abnormal_eye_development0.90185283
95MP0000432_abnormal_head_morphology0.89981021
96* MP0002111_abnormal_tail_morphology0.89412339
97* MP0002085_abnormal_embryonic_tissue0.88399576
98MP0000678_abnormal_parathyroid_gland0.87707903
99MP0004264_abnormal_extraembryonic_tissu0.87025449
100MP0001299_abnormal_eye_distance/0.86490772
101MP0008057_abnormal_DNA_replication0.84648433
102MP0005508_abnormal_skeleton_morphology0.83935291
103MP0001958_emphysema0.83684232
104MP0005197_abnormal_uvea_morphology0.82017839
105MP0003718_maternal_effect0.81656389
106MP0002088_abnormal_embryonic_growth/wei0.81362818
107MP0010094_abnormal_chromosome_stability0.81181742
108MP0008260_abnormal_autophagy0.80528687
109MP0000681_abnormal_thyroid_gland0.80410118
110MP0000534_abnormal_ureter_morphology0.79631209
111MP0002295_abnormal_pulmonary_circulatio0.79578031
112MP0000778_abnormal_nervous_system0.79508701
113MP0000350_abnormal_cell_proliferation0.79422054
114MP0004133_heterotaxia0.79414795
115* MP0002084_abnormal_developmental_patter0.78288985
116MP0002133_abnormal_respiratory_system0.77667346
117MP0005388_respiratory_system_phenotype0.77667346
118* MP0001697_abnormal_embryo_size0.76488373
119MP0008007_abnormal_cellular_replicative0.75659585
120MP0004197_abnormal_fetal_growth/weight/0.75383021
121MP0005623_abnormal_meninges_morphology0.74207857
122MP0000367_abnormal_coat/_hair0.72971696
123MP0000613_abnormal_salivary_gland0.71600139
124MP0002653_abnormal_ependyma_morphology0.70885986
125* MP0002114_abnormal_axial_skeleton0.70349684
126MP0005257_abnormal_intraocular_pressure0.69702704
127MP0004484_altered_response_of0.69302818
128MP0009384_cardiac_valve_regurgitation0.68492815
129MP0003984_embryonic_growth_retardation0.68463136
130MP0005395_other_phenotype0.68367787
131MP0009250_abnormal_appendicular_skeleto0.68296923
132MP0004185_abnormal_adipocyte_glucose0.66861223
133MP0002177_abnormal_outer_ear0.66589040
134MP0002109_abnormal_limb_morphology0.65664306
135* MP0002080_prenatal_lethality0.65447941
136MP0004272_abnormal_basement_membrane0.65203251
137MP0000750_abnormal_muscle_regeneration0.64489944
138MP0000163_abnormal_cartilage_morphology0.64302931
139MP0009278_abnormal_bone_marrow0.63657194
140MP0001243_abnormal_dermal_layer0.63244926
141MP0005367_renal/urinary_system_phenotyp0.62782046
142MP0000516_abnormal_urinary_system0.62782046
143MP0001191_abnormal_skin_condition0.62523988
144MP0002168_other_aberrant_phenotype0.61207504
145MP0003942_abnormal_urinary_system0.61138412
146MP0002152_abnormal_brain_morphology0.61036492
147MP0003890_abnormal_embryonic-extraembry0.60944037
148MP0002081_perinatal_lethality0.60593082
149MP0008770_decreased_survivor_rate0.60406117
150MP0006138_congestive_heart_failure0.60173388
151MP0001544_abnormal_cardiovascular_syste0.60169762
152MP0005385_cardiovascular_system_phenoty0.60169762
153MP0002282_abnormal_trachea_morphology0.59299904

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)6.07783755
2Septate vagina (HP:0001153)5.22377777
3Milia (HP:0001056)4.78454462
4Broad distal phalanx of finger (HP:0009836)4.73639767
5Hypoplasia of the pons (HP:0012110)4.46793837
6Pili torti (HP:0003777)4.10880027
7Plantar hyperkeratosis (HP:0007556)4.00551955
8Stenosis of the external auditory canal (HP:0000402)3.92908898
9Aplasia involving bones of the extremities (HP:0009825)3.86290708
10Aplasia involving bones of the upper limbs (HP:0009823)3.86290708
11Aplasia of the phalanges of the hand (HP:0009802)3.86290708
12Abnormality of the pons (HP:0007361)3.81721603
13Prolonged neonatal jaundice (HP:0006579)3.81404866
14Ulnar bowing (HP:0003031)3.79667455
15Ileus (HP:0002595)3.76498386
16Thin ribs (HP:0000883)3.61497999
17Onycholysis (HP:0001806)3.51584232
18Atrophic scars (HP:0001075)3.50698009
19Esophageal atresia (HP:0002032)3.45613427
20Abnormality of the aortic arch (HP:0012303)3.44221865
21Woolly hair (HP:0002224)3.39202414
22Myopathic facies (HP:0002058)3.33723266
23Hypotrichosis (HP:0001006)3.31338496
24Breast hypoplasia (HP:0003187)3.24941843
25Coronal craniosynostosis (HP:0004440)3.21564275
26Hypoparathyroidism (HP:0000829)3.15956778
27Overriding aorta (HP:0002623)3.14369137
28Bell-shaped thorax (HP:0001591)3.14137837
29Nausea (HP:0002018)3.13944293
30High anterior hairline (HP:0009890)3.13606789
31Reticulocytopenia (HP:0001896)3.12940004
32Polycythemia (HP:0001901)3.09985856
33Abnormal hemoglobin (HP:0011902)3.07645725
34Abnormality of cochlea (HP:0000375)3.06377572
35Abnormality of liposaccharide metabolism (HP:0010968)3.06244841
36Abnormality of glycosphingolipid metabolism (HP:0004343)3.06244841
37Abnormality of glycolipid metabolism (HP:0010969)3.06244841
38Nail dystrophy (HP:0008404)3.05468272
39Concave nail (HP:0001598)3.03198860
40Right ventricular cardiomyopathy (HP:0011663)2.98049536
41Abnormality of cells of the erythroid lineage (HP:0012130)2.97455089
42Abnormal blistering of the skin (HP:0008066)2.96232166
43Abnormality of the parietal bone (HP:0002696)2.92852551
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.86797035
45Interstitial pulmonary disease (HP:0006530)2.83988438
46Macrocytic anemia (HP:0001972)2.82895371
47Cutaneous finger syndactyly (HP:0010554)2.82738712
48Sparse eyelashes (HP:0000653)2.82378884
49Secondary amenorrhea (HP:0000869)2.82064432
50Aplasia cutis congenita (HP:0001057)2.81431940
51Cutaneous syndactyly (HP:0012725)2.79763895
52Turricephaly (HP:0000262)2.75387360
53Hyperlipoproteinemia (HP:0010980)2.75050554
54Split foot (HP:0001839)2.72581293
55Abnormality of the middle phalanges of the toes (HP:0010183)2.70914421
56Bronchomalacia (HP:0002780)2.70004462
57Duplication of thumb phalanx (HP:0009942)2.67720064
58Abnormality of the umbilical cord (HP:0010881)2.66474570
59Vitreoretinal degeneration (HP:0000655)2.65320967
60Blepharitis (HP:0000498)2.64963091
61Selective tooth agenesis (HP:0001592)2.61396927
62Gonadotropin excess (HP:0000837)2.58572808
63Abnormality of the phalanges of the 2nd finger (HP:0009541)2.58281877
64Abnormality of nail color (HP:0100643)2.56478426
65Abnormality of the fetal cardiovascular system (HP:0010948)2.54885225
66Abnormal umbilical cord blood vessels (HP:0011403)2.54885225
67Single umbilical artery (HP:0001195)2.54885225
68Transposition of the great arteries (HP:0001669)2.53921111
69Abnormal connection of the cardiac segments (HP:0011545)2.53921111
70Abnormal ventriculo-arterial connection (HP:0011563)2.53921111
71Synostosis of carpal bones (HP:0005048)2.53554732
72Broad thumb (HP:0011304)2.52496883
73Trigonocephaly (HP:0000243)2.51571197
74Amelogenesis imperfecta (HP:0000705)2.51525017
75Tracheomalacia (HP:0002779)2.47210089
76Mixed hearing impairment (HP:0000410)2.44850198
77Premature ovarian failure (HP:0008209)2.44543508
78Congenital malformation of the right heart (HP:0011723)2.40574312
79Double outlet right ventricle (HP:0001719)2.40574312
80Hyperacusis (HP:0010780)2.37385132
81Athetosis (HP:0002305)2.36937533
82Morphological abnormality of the inner ear (HP:0011390)2.34815222
83Broad toe (HP:0001837)2.33935538
84Abnormality of the dental root (HP:0006486)2.33136444
85Taurodontia (HP:0000679)2.33136444
86Abnormality of permanent molar morphology (HP:0011071)2.33136444
87Carpal synostosis (HP:0009702)2.32991743
88Hypoplastic left heart (HP:0004383)2.32534152
89Absent forearm bone (HP:0003953)2.27795908
90Aplasia involving forearm bones (HP:0009822)2.27795908
91Alopecia of scalp (HP:0002293)2.27736082
92Absent radius (HP:0003974)2.26266343
93Cerebral hypomyelination (HP:0006808)2.25960596
94Palmoplantar hyperkeratosis (HP:0000972)2.25126696
95Abnormality of the lacrimal duct (HP:0011481)2.24351573
96Abnormality of the phalanges of the hallux (HP:0010057)2.23030202
97Alacrima (HP:0000522)2.21398686
98Pallor (HP:0000980)2.21395478
99Palmar hyperkeratosis (HP:0010765)2.20367437
100Broad hallux (HP:0010055)2.19680207
101Abnormality of the 2nd finger (HP:0004100)2.18525695
102Broad phalanges of the hand (HP:0009768)2.17697278
103Hypoplastic pelvis (HP:0008839)2.17426090
104Preaxial foot polydactyly (HP:0001841)2.17256192
105Abnormal number of erythroid precursors (HP:0012131)2.16326351
106Abnormality of the distal phalanges of the toes (HP:0010182)2.16297605
107Esophageal varix (HP:0002040)2.15136771
108Rib fusion (HP:0000902)2.13848294
109Short 5th finger (HP:0009237)2.13169292
110Truncus arteriosus (HP:0001660)2.11924603
111Hypoalphalipoproteinemia (HP:0003233)2.11285239
112Cheilitis (HP:0100825)2.10720410
113Buphthalmos (HP:0000557)2.09591333
114Down-sloping shoulders (HP:0200021)2.09429011
115Abnormality of molar (HP:0011077)2.09366530
116Abnormality of molar morphology (HP:0011070)2.09366530
117Renal dysplasia (HP:0000110)2.08045980
118Trismus (HP:0000211)2.07747847
119Myelomeningocele (HP:0002475)2.07636976
120Abnormality of the salivary glands (HP:0010286)2.07193459
121Gastrointestinal atresia (HP:0002589)2.06572867
122Oligodactyly (HP:0012165)2.06251939
123Broad finger (HP:0001500)2.05838818
124Short middle phalanx of finger (HP:0005819)2.03940611
125Poor head control (HP:0002421)2.03743533
126Parakeratosis (HP:0001036)2.03374055
127Abnormality of macrophages (HP:0004311)2.02526534
128Acanthosis nigricans (HP:0000956)2.01712378
129Xanthomatosis (HP:0000991)2.01322078
130Flattened epiphyses (HP:0003071)2.01218300
131Death in infancy (HP:0001522)2.00950159
132Distal lower limb muscle weakness (HP:0009053)1.99129541
133Oral leukoplakia (HP:0002745)1.98268737
134Abnormality of the dental pulp (HP:0006479)1.98050037
135Thick nail (HP:0001805)1.96518103
136Micronodular cirrhosis (HP:0001413)1.95885853
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95443761
138Congenital, generalized hypertrichosis (HP:0004540)1.94282379
139Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93319451
140Facial cleft (HP:0002006)1.92777098
141Arnold-Chiari malformation (HP:0002308)1.91576980
142Pulmonary artery stenosis (HP:0004415)1.87857434
143Abnormally folded helix (HP:0008544)1.87250809
144Fused cervical vertebrae (HP:0002949)1.85639874
145Ureteral duplication (HP:0000073)1.85596940
146Abnormality of the nasolacrimal system (HP:0000614)1.85515088
147Abnormal hair laboratory examination (HP:0003328)1.84598420
148Premature skin wrinkling (HP:0100678)1.84557682
149Synostosis involving bones of the hand (HP:0004278)1.84494124
150Diminished motivation (HP:0000745)1.84335800
151Natal tooth (HP:0000695)1.84311921
152Limited elbow extension (HP:0001377)1.84168735
153Partial duplication of the phalanx of hand (HP:0009999)1.83858698
154Hypoplastic heart (HP:0001961)1.81711768
155Nasolacrimal duct obstruction (HP:0000579)1.81463393
156Carpal bone hypoplasia (HP:0001498)1.79834986
157Aplasia/Hypoplasia of the ulna (HP:0006495)1.79727305
158Seborrheic dermatitis (HP:0001051)1.79503981
159Renal duplication (HP:0000075)1.79484730
160Broad phalanx (HP:0006009)1.78937719
161Partial duplication of thumb phalanx (HP:0009944)1.78669899
162Humeroradial synostosis (HP:0003041)1.78334787
163Synostosis involving the elbow (HP:0003938)1.78334787
164Decreased lacrimation (HP:0000633)1.78029354
165Congenital glaucoma (HP:0001087)1.77986728
166Bowed forearm bones (HP:0003956)1.77682730
167Bowing of the arm (HP:0006488)1.77682730
168Atresia of the external auditory canal (HP:0000413)1.77561775
169Lip pit (HP:0100267)1.77286661
170Pterygium (HP:0001059)1.76962860
171Bifid scrotum (HP:0000048)1.76049655
172Absent thumb (HP:0009777)1.75898787
173Shawl scrotum (HP:0000049)1.75680849
174Ankyloglossia (HP:0010296)1.74493375
175Choanal stenosis (HP:0000452)1.73862457
176Ridged nail (HP:0001807)1.73258149
177Preaxial hand polydactyly (HP:0001177)1.72178371
178Difficulty climbing stairs (HP:0003551)1.71825586
179Apathy (HP:0000741)1.70833730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG15.09643313
2VRK24.18405054
3WEE14.01086573
4BUB13.67303182
5MAP3K103.02616960
6RPS6KB22.99738755
7EEF2K2.96414338
8MAP3K32.54045274
9SIK12.39878161
10ICK2.19739675
11EPHA210.9149451
12MAP2K21.97996352
13TAF11.86393522
14DYRK31.74767045
15MAPKAPK31.66836906
16STK161.65998808
17TAOK11.64851478
18PRKD31.64675601
19FER1.60712982
20SRPK11.58121612
21TTK1.55700195
22PKN21.52746101
23MAP2K31.49419519
24IRAK31.45273951
25LATS21.44831423
26MAP3K111.44534861
27PNCK1.42351512
28TRIB31.41826678
29CDK121.41466234
30LATS11.37922923
31EPHB21.33354928
32TAOK21.32658812
33PAK41.26884202
34TSSK61.26382147
35TLK11.20776676
36MST41.20594858
37LRRK21.19292442
38BRSK21.13121045
39NEK11.10547817
40AURKA1.10437987
41PRKCI1.09611981
42NEK21.07855902
43ILK1.04174200
44AKT31.00740483
45MAP3K80.99109923
46FGFR20.93717817
47STK100.92676641
48MAP3K10.91420803
49NME10.90388500
50CDK80.90383006
51CSNK1A1L0.89514635
52CDC70.89227815
53AURKB0.87236833
54CSNK1G30.85520826
55STK40.85375270
56NME20.85077616
57NTRK10.84342257
58ATR0.83937972
59PDK20.82657505
60TESK10.82141225
61GRK60.80816455
62STK240.80408073
63PLK10.78505845
64KDR0.77845665
65MAP2K60.72747612
66CDK70.71937391
67CHUK0.71526282
68CDK40.71262083
69PDK30.71243974
70PDK40.71243974
71TIE10.71173275
72TGFBR10.70709112
73MAPK150.70659297
74NEK90.70012942
75BCKDK0.68247810
76MARK10.67531687
77PDGFRA0.66249542
78STK38L0.66142418
79PAK10.64890050
80IRAK20.64656312
81ZAK0.63402646
82CSNK1G10.63079500
83PLK40.61995742
84RPS6KA50.59611182
85CDK90.59278393
86CHEK10.58988939
87MAP2K10.58966039
88PTK60.58806476
89TYRO30.57065387
90PBK0.56275202
91FGFR40.55642119
92RPS6KA20.52581667
93DDR20.51449910
94MST1R0.50974715
95PLK30.50627137
96MET0.50504084
97CAMK1G0.48554545
98BRD40.47880138
99ERBB30.47828508
100BRSK10.46932160
101RPS6KC10.46584844
102RPS6KL10.46584844
103MELK0.46511716
104MARK30.46506748
105MUSK0.45976099
106CDK10.45674658
107RIPK10.45221373
108EPHA40.44184237
109EIF2AK20.43529704
110SCYL20.42630887
111BRAF0.42557320
112CAMK1D0.41210406
113TTN0.40172430
114BMX0.39699445
115CSNK1E0.39283351
116CSNK1G20.38386383
117PASK0.37831630
118RPS6KA60.37306643
119CDK60.37227417
120RPS6KA10.36102257
121MAPKAPK20.36004790
122RPS6KA40.35381386
123CHEK20.35208038
124MTOR0.34833992
125DAPK10.33619389
126DAPK30.33337695
127CSNK2A10.32184512
128LMTK20.32107734
129GRK10.31774761
130PRPF4B0.31222547
131VRK10.30948465
132MAP2K70.30450155
133MAPK110.30259901
134DYRK1B0.28839383
135FGFR10.28824593
136PTK20.28635332
137AKT20.28131914
138TYK20.27926253
139MAPK120.27692205
140TGFBR20.27267889
141MAP3K90.26885757
142CDK20.26631287
143ROCK20.26386820
144EPHB10.26346224
145NLK0.26243616
146CAMK2B0.25400240
147DYRK20.24897184
148CAMK2G0.24505732
149STK110.21889972
150ABL20.21845559
151MAPK90.21225245
152PRKCD0.20017738
153CSNK2A20.19691182
154BCR0.19164667
155ALK0.18700034

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.00701230
2Proteasome_Homo sapiens_hsa030504.56638144
3* Hedgehog signaling pathway_Homo sapiens_hsa043402.74297435
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.60168235
5* Hippo signaling pathway_Homo sapiens_hsa043902.52761983
6Tight junction_Homo sapiens_hsa045302.40266192
7* Basal cell carcinoma_Homo sapiens_hsa052172.35181697
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35095774
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.33475052
10RNA transport_Homo sapiens_hsa030132.30521793
11Spliceosome_Homo sapiens_hsa030402.23608286
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.18031431
13Fructose and mannose metabolism_Homo sapiens_hsa000512.17709466
14RNA polymerase_Homo sapiens_hsa030202.13734519
15Base excision repair_Homo sapiens_hsa034101.83881837
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.82680504
17Arachidonic acid metabolism_Homo sapiens_hsa005901.77280701
18DNA replication_Homo sapiens_hsa030301.74455148
19Adherens junction_Homo sapiens_hsa045201.56220864
20p53 signaling pathway_Homo sapiens_hsa041151.53005007
21Mismatch repair_Homo sapiens_hsa034301.49565843
22Cell cycle_Homo sapiens_hsa041101.44550330
23One carbon pool by folate_Homo sapiens_hsa006701.27028193
24Pyrimidine metabolism_Homo sapiens_hsa002401.20895028
25Glutathione metabolism_Homo sapiens_hsa004801.20384710
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18473433
27Bladder cancer_Homo sapiens_hsa052191.14847119
28* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14303956
29Fanconi anemia pathway_Homo sapiens_hsa034601.12323808
30Regulation of autophagy_Homo sapiens_hsa041401.10716307
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09475846
32Sphingolipid metabolism_Homo sapiens_hsa006001.07530780
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06844201
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.05827290
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.05746884
36Vitamin digestion and absorption_Homo sapiens_hsa049771.05662302
37ECM-receptor interaction_Homo sapiens_hsa045121.04730781
38Folate biosynthesis_Homo sapiens_hsa007901.00095825
39Lysine degradation_Homo sapiens_hsa003100.99516091
40Endometrial cancer_Homo sapiens_hsa052130.99459715
41Nucleotide excision repair_Homo sapiens_hsa034200.97379263
42Oocyte meiosis_Homo sapiens_hsa041140.97315507
43Pentose phosphate pathway_Homo sapiens_hsa000300.95434314
44* Proteoglycans in cancer_Homo sapiens_hsa052050.95278554
45Endocytosis_Homo sapiens_hsa041440.94401204
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93193086
47Alcoholism_Homo sapiens_hsa050340.92269307
48Small cell lung cancer_Homo sapiens_hsa052220.91427269
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90415480
50Systemic lupus erythematosus_Homo sapiens_hsa053220.89717422
51Linoleic acid metabolism_Homo sapiens_hsa005910.89200344
52Non-homologous end-joining_Homo sapiens_hsa034500.87930599
53Mineral absorption_Homo sapiens_hsa049780.83809359
54N-Glycan biosynthesis_Homo sapiens_hsa005100.82643009
55Parkinsons disease_Homo sapiens_hsa050120.82483564
56Shigellosis_Homo sapiens_hsa051310.82230051
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81457313
58Circadian rhythm_Homo sapiens_hsa047100.80832310
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80792170
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79929623
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79673257
62Thyroid cancer_Homo sapiens_hsa052160.78523537
63Vitamin B6 metabolism_Homo sapiens_hsa007500.78093994
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77965870
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.77960248
66Homologous recombination_Homo sapiens_hsa034400.77320110
67Caffeine metabolism_Homo sapiens_hsa002320.77188326
68* HTLV-I infection_Homo sapiens_hsa051660.74985688
69Epstein-Barr virus infection_Homo sapiens_hsa051690.73741313
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72409850
71Notch signaling pathway_Homo sapiens_hsa043300.71516622
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69186545
73Colorectal cancer_Homo sapiens_hsa052100.68238970
74RNA degradation_Homo sapiens_hsa030180.68181755
75Chronic myeloid leukemia_Homo sapiens_hsa052200.66787334
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65508019
77* Pathways in cancer_Homo sapiens_hsa052000.64769013
78Non-small cell lung cancer_Homo sapiens_hsa052230.64205185
79Lysosome_Homo sapiens_hsa041420.64000938
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63647123
81Alzheimers disease_Homo sapiens_hsa050100.61001223
82Renal cell carcinoma_Homo sapiens_hsa052110.59793534
83Prostate cancer_Homo sapiens_hsa052150.57934123
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57745982
85Selenocompound metabolism_Homo sapiens_hsa004500.57299247
86Galactose metabolism_Homo sapiens_hsa000520.57182690
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56522393
88mRNA surveillance pathway_Homo sapiens_hsa030150.56432622
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56010174
90* MicroRNAs in cancer_Homo sapiens_hsa052060.55914374
91Basal transcription factors_Homo sapiens_hsa030220.55167014
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55124743
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.55053905
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54662655
95* Wnt signaling pathway_Homo sapiens_hsa043100.53845186
96Glioma_Homo sapiens_hsa052140.53469357
97Inositol phosphate metabolism_Homo sapiens_hsa005620.53137326
98Retinol metabolism_Homo sapiens_hsa008300.52835247
99Fat digestion and absorption_Homo sapiens_hsa049750.52634537
100Protein digestion and absorption_Homo sapiens_hsa049740.52355313
101Purine metabolism_Homo sapiens_hsa002300.52247815
102Phenylalanine metabolism_Homo sapiens_hsa003600.51211229
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50305769
104Focal adhesion_Homo sapiens_hsa045100.50255922
105Renin-angiotensin system_Homo sapiens_hsa046140.49344589
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49062197
107* Melanogenesis_Homo sapiens_hsa049160.48771483
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48008776
109Carbon metabolism_Homo sapiens_hsa012000.47991938
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45201582
111VEGF signaling pathway_Homo sapiens_hsa043700.44533422
112Huntingtons disease_Homo sapiens_hsa050160.44073708
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43598971
114Axon guidance_Homo sapiens_hsa043600.43070938
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41604409
116Sulfur relay system_Homo sapiens_hsa041220.40429232
117beta-Alanine metabolism_Homo sapiens_hsa004100.39778120
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.39631916
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.39348178
120Insulin signaling pathway_Homo sapiens_hsa049100.37836455
121TGF-beta signaling pathway_Homo sapiens_hsa043500.36341937
122Ether lipid metabolism_Homo sapiens_hsa005650.34681564
123ErbB signaling pathway_Homo sapiens_hsa040120.34290226
124Arginine and proline metabolism_Homo sapiens_hsa003300.34163086
125mTOR signaling pathway_Homo sapiens_hsa041500.33090727
126Vibrio cholerae infection_Homo sapiens_hsa051100.32785212
127Biosynthesis of amino acids_Homo sapiens_hsa012300.32691381
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32439206
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32068669
130Oxidative phosphorylation_Homo sapiens_hsa001900.30906321
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29882960
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29733315
133AMPK signaling pathway_Homo sapiens_hsa041520.29638826
134Metabolic pathways_Homo sapiens_hsa011000.27842197
135Arginine biosynthesis_Homo sapiens_hsa002200.27382564
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26368054
137Melanoma_Homo sapiens_hsa052180.25731920
138Amoebiasis_Homo sapiens_hsa051460.23526855

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