WNT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.91194115
2Golgi transport vesicle coating (GO:0048200)5.91194115
3type B pancreatic cell development (GO:0003323)5.66850529
4endocrine pancreas development (GO:0031018)5.48098158
5glandular epithelial cell development (GO:0002068)5.15931134
6peptide hormone processing (GO:0016486)4.56684008
7regulation of type B pancreatic cell apoptotic process (GO:2000674)4.43042620
8* glandular epithelial cell differentiation (GO:0002067)4.42476359
9desmosome organization (GO:0002934)4.36524990
10hemidesmosome assembly (GO:0031581)4.31532397
11protein maturation by protein folding (GO:0022417)4.23792415
12exocrine pancreas development (GO:0031017)4.10973804
13positive regulation of glycolytic process (GO:0045821)4.01428254
14columnar/cuboidal epithelial cell development (GO:0002066)3.97936526
15negative regulation of keratinocyte proliferation (GO:0010839)3.87687135
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.85373198
17signal peptide processing (GO:0006465)3.80599977
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.76751365
19COPII vesicle coating (GO:0048208)3.74299815
20negative regulation of cytosolic calcium ion concentration (GO:0051481)3.73754986
21insulin secretion (GO:0030073)3.69696259
22nucleoside diphosphate catabolic process (GO:0009134)3.66300754
23cornea development in camera-type eye (GO:0061303)3.63338463
24interleukin-1-mediated signaling pathway (GO:0070498)3.58325548
25cellular response to vitamin D (GO:0071305)3.56392036
26positive regulation of respiratory burst (GO:0060267)3.55101109
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.54556042
28negative regulation of osteoblast proliferation (GO:0033689)3.53957970
29cellular ketone body metabolic process (GO:0046950)3.53582312
30positive regulation of insulin secretion (GO:0032024)3.51333941
31regulation of water loss via skin (GO:0033561)3.47051671
32water-soluble vitamin biosynthetic process (GO:0042364)3.45830127
33chemosensory behavior (GO:0007635)3.45694793
34multicellular organismal water homeostasis (GO:0050891)3.43972803
35regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.43480879
36dendritic spine morphogenesis (GO:0060997)3.42653282
37negative regulation of gluconeogenesis (GO:0045721)3.41387980
38kidney morphogenesis (GO:0060993)3.35776744
39detection of calcium ion (GO:0005513)3.32306512
40protein retention in ER lumen (GO:0006621)3.31595343
41regulation of pigment cell differentiation (GO:0050932)3.31060507
42negative regulation of protein oligomerization (GO:0032460)3.28919447
43negative regulation of norepinephrine secretion (GO:0010700)3.27502707
44epithelial cell fate commitment (GO:0072148)3.26562697
45regulation of hexokinase activity (GO:1903299)3.22336828
46regulation of glucokinase activity (GO:0033131)3.22336828
47ketone body metabolic process (GO:1902224)3.18132971
48establishment of skin barrier (GO:0061436)3.17604643
49gland morphogenesis (GO:0022612)3.17097802
50positive regulation of gastrulation (GO:2000543)3.12604855
51auditory receptor cell differentiation (GO:0042491)3.10245728
52glycerophospholipid catabolic process (GO:0046475)3.09074688
53regulation of insulin secretion (GO:0050796)3.04890445
54macroautophagy (GO:0016236)3.04495986
55ganglion development (GO:0061548)3.04356352
56keratinocyte development (GO:0003334)3.00363080
57inositol phosphate catabolic process (GO:0071545)2.99621740
58ER overload response (GO:0006983)2.96689203
59negative regulation of activin receptor signaling pathway (GO:0032926)2.94672041
60nephron tubule morphogenesis (GO:0072078)2.94069012
61nephron epithelium morphogenesis (GO:0072088)2.94069012
62sequestering of metal ion (GO:0051238)2.93554274
63intraciliary transport (GO:0042073)2.92741433
64astrocyte differentiation (GO:0048708)2.89058698
65neuron fate specification (GO:0048665)2.86643887
66positive regulation of glycogen biosynthetic process (GO:0045725)2.85744153
67negative regulation of glycoprotein biosynthetic process (GO:0010561)2.85235093
68regulation of keratinocyte proliferation (GO:0010837)2.84931054
69respiratory chain complex IV assembly (GO:0008535)2.84310069
70toxin metabolic process (GO:0009404)2.83962596
71regulation of calcium ion-dependent exocytosis (GO:0017158)2.83652474
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83570567
73neuron fate determination (GO:0048664)2.83446936
74negative regulation of glycogen biosynthetic process (GO:0045719)2.79950940
75regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.78771141
76epithelial cilium movement (GO:0003351)2.77501209
77peptide hormone secretion (GO:0030072)2.76960279
78polyol catabolic process (GO:0046174)2.76598840
79regulation of peptide hormone secretion (GO:0090276)2.76591351
80nitric oxide biosynthetic process (GO:0006809)2.75593490
81phosphorylated carbohydrate dephosphorylation (GO:0046838)2.75449912
82inositol phosphate dephosphorylation (GO:0046855)2.75449912
83protein localization to cilium (GO:0061512)2.74548624
84pancreas development (GO:0031016)2.73467536
85regulation of peptide secretion (GO:0002791)2.72773479
86positive regulation of macroautophagy (GO:0016239)2.72566482
87cellular response to antibiotic (GO:0071236)2.72463110
88artery smooth muscle contraction (GO:0014824)2.70457757
89induction of positive chemotaxis (GO:0050930)2.70006012
90establishment of protein localization to Golgi (GO:0072600)2.69921024
91righting reflex (GO:0060013)2.69506596
92retinal ganglion cell axon guidance (GO:0031290)2.69274688
93cytochrome complex assembly (GO:0017004)2.69121541
94protein targeting to Golgi (GO:0000042)2.68941899
95peptide secretion (GO:0002790)2.68613256
96axoneme assembly (GO:0035082)2.68018787
97pharyngeal system development (GO:0060037)2.67744006
98activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67535924
99phenylpropanoid metabolic process (GO:0009698)2.66584466
100cellular response to vitamin (GO:0071295)2.66383604
101somite rostral/caudal axis specification (GO:0032525)2.64287859
102xenobiotic catabolic process (GO:0042178)2.64211511
103inner ear receptor cell development (GO:0060119)2.63771875
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.62721551
105nephron tubule formation (GO:0072079)2.61659342
106negative regulation of Ras GTPase activity (GO:0034261)2.61611900
107regulation of energy homeostasis (GO:2000505)2.60561320
108positive regulation of hormone secretion (GO:0046887)2.60138728
109positive regulation of peptide hormone secretion (GO:0090277)2.59927795
110developmental pigmentation (GO:0048066)2.59886394
111regulation of uterine smooth muscle contraction (GO:0070472)2.59878149
112water homeostasis (GO:0030104)2.59404787
113norepinephrine metabolic process (GO:0042415)2.58117702
114negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55685819
115regulation of hormone secretion (GO:0046883)2.55294379
116protein localization to Golgi apparatus (GO:0034067)2.55049733
117regulation of apoptotic process involved in morphogenesis (GO:1902337)2.54985022
118positive regulation of response to extracellular stimulus (GO:0032106)2.54981112
119positive regulation of response to nutrient levels (GO:0032109)2.54981112
120preassembly of GPI anchor in ER membrane (GO:0016254)2.54841216
121positive regulation of glycogen metabolic process (GO:0070875)2.54675289
122retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53943695
123nitric oxide mediated signal transduction (GO:0007263)2.53905526
124positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.53558525
125* androgen biosynthetic process (GO:0006702)2.53458741
126positive regulation of peptide secretion (GO:0002793)2.53305467
127calcium ion import (GO:0070509)2.52856075
128negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.51394770
129ear development (GO:0043583)2.51388947
130keratinization (GO:0031424)2.51213761
131regulation of acrosome reaction (GO:0060046)2.50706896
132response to pheromone (GO:0019236)2.50340502
133presynaptic membrane assembly (GO:0097105)2.50099892
134renal tubule morphogenesis (GO:0061333)2.49787668
135* positive regulation of bone mineralization (GO:0030501)2.49456077
136dentate gyrus development (GO:0021542)2.48979743
137innervation (GO:0060384)2.48308983
138regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.47975812
139* positive regulation of biomineral tissue development (GO:0070169)2.47493474
140protein complex biogenesis (GO:0070271)2.47485193
141regulation of autophagic vacuole assembly (GO:2000785)2.47479779
142regulation of cilium movement (GO:0003352)2.46322043
143signal transduction involved in regulation of gene expression (GO:0023019)2.46316108
144retinol metabolic process (GO:0042572)2.45757280
145positive regulation of nuclease activity (GO:0032075)2.45061751
146peptide transport (GO:0015833)2.44586339
147* mesenchymal cell differentiation (GO:0048762)2.44198992
148positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.43058401
149vesicle coating (GO:0006901)2.42920403
150nonmotile primary cilium assembly (GO:0035058)2.42818878
151smoothened signaling pathway (GO:0007224)2.42672457
152negative regulation of acute inflammatory response (GO:0002674)2.42279702
153negative regulation of bone resorption (GO:0045779)2.41591068
154lactate metabolic process (GO:0006089)2.41430025
155intra-Golgi vesicle-mediated transport (GO:0006891)2.41054767
156negative regulation of insulin secretion (GO:0046676)2.40988330
157facial nerve structural organization (GO:0021612)2.40750875
158regulation of mesenchymal cell apoptotic process (GO:2001053)2.40417776
159epithelial cell maturation (GO:0002070)2.40351250
160collecting duct development (GO:0072044)2.39529243
161postsynaptic membrane organization (GO:0001941)2.38779209
162bundle of His cell to Purkinje myocyte communication (GO:0086069)2.37867699
163regulation of mesonephros development (GO:0061217)2.36450722
164regulation of secondary heart field cardioblast proliferation (GO:0003266)2.36240927
165regulation of cardioblast proliferation (GO:0003264)2.36240927
166regulation of transcription involved in cell fate commitment (GO:0060850)2.36133437
167negative regulation of catecholamine secretion (GO:0033604)2.35878714
168sphingoid metabolic process (GO:0046519)2.35290968
169magnesium ion transport (GO:0015693)2.34814084
170positive regulation of protein kinase C signaling (GO:0090037)2.34112546
171positive regulation of calcium ion import (GO:0090280)2.33992985
172anatomical structure arrangement (GO:0048532)2.32913667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.18753067
2EZH2_22144423_ChIP-Seq_EOC_Human2.99691941
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81192399
4GBX2_23144817_ChIP-Seq_PC3_Human2.25393228
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.24476317
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.21360768
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19246624
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16846324
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16554657
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11772410
11GATA1_22025678_ChIP-Seq_K562_Human2.08701097
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02785175
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02195979
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97492439
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93431060
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.89168581
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88831026
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87452574
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86815613
20ZNF274_21170338_ChIP-Seq_K562_Hela1.85672811
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85069166
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85069166
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.84181338
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81500304
25FUS_26573619_Chip-Seq_HEK293_Human1.79521812
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.79164182
27TAF15_26573619_Chip-Seq_HEK293_Human1.78026259
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.76719562
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76414068
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.72577885
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72218959
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70489736
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64236031
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61599731
35HTT_18923047_ChIP-ChIP_STHdh_Human1.60017816
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58365181
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56679381
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56525330
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53114577
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52946108
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51343247
42VDR_22108803_ChIP-Seq_LS180_Human1.50484062
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.50419095
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47799839
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46789968
46IGF1R_20145208_ChIP-Seq_DFB_Human1.46273411
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.44719247
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43089138
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42141860
50TP53_18474530_ChIP-ChIP_U2OS_Human1.38574489
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38520732
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37257837
53ER_23166858_ChIP-Seq_MCF-7_Human1.34996630
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32797555
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32710907
56EWS_26573619_Chip-Seq_HEK293_Human1.28876412
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.28380715
58CDX2_22108803_ChIP-Seq_LS180_Human1.25677846
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25208557
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24891723
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24249558
62RNF2_27304074_Chip-Seq_NSC_Mouse1.23878004
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23611090
64CBP_20019798_ChIP-Seq_JUKART_Human1.23611090
65* TCF4_22108803_ChIP-Seq_LS180_Human1.23094258
66SMAD4_21799915_ChIP-Seq_A2780_Human1.21890155
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21392673
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21018178
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20912106
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.20908860
71TP53_22573176_ChIP-Seq_HFKS_Human1.20882160
72TCF4_23295773_ChIP-Seq_U87_Human1.20823898
73* NANOG_18555785_Chip-Seq_ESCs_Mouse1.20436011
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17596316
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.16477121
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15503752
77P53_22387025_ChIP-Seq_ESCs_Mouse1.15466898
78AHR_22903824_ChIP-Seq_MCF-7_Human1.15244668
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13951855
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11836692
81AR_21572438_ChIP-Seq_LNCaP_Human1.11405999
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10255886
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.09697531
84* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09168064
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09160349
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08318384
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08012615
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08012615
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07233926
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.07209601
91SOX2_20726797_ChIP-Seq_SW620_Human1.06748558
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.06723239
93NANOG_19829295_ChIP-Seq_ESCs_Human1.06145696
94SOX2_19829295_ChIP-Seq_ESCs_Human1.06145696
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.06015295
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05199590
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05077649
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.04496058
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.04054499
100REST_21632747_ChIP-Seq_MESCs_Mouse1.03438400
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03256589
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.02825901
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02324568
104* TBL1_22424771_ChIP-Seq_293T_Human1.02172943
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01496334
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.01436982
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.01022700
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01022700
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99945809
110* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99902226
111* BCAT_22108803_ChIP-Seq_LS180_Human0.99771096
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99624892
113* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99596051
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.98552019
115TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97777265
116SOX2_18555785_Chip-Seq_ESCs_Mouse0.97537680
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96776877
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96015984
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95007213
120P300_19829295_ChIP-Seq_ESCs_Human0.94981928
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.93642329
122STAT3_23295773_ChIP-Seq_U87_Human0.93498584
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.92767890
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92006349
125* RUNX2_22187159_ChIP-Seq_PCA_Human0.91942013
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91456558
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91410084
128* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90833511
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.90642554
130P300_18555785_Chip-Seq_ESCs_Mouse0.90170374
131AR_25329375_ChIP-Seq_VCAP_Human0.89550767
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89354180
133* ZFX_18555785_Chip-Seq_ESCs_Mouse0.89175401
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.89141076
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.88660402
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88403415
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88333779
138* SMAD3_21741376_ChIP-Seq_HESCs_Human0.88251814
139DROSHA_22980978_ChIP-Seq_HELA_Human0.87123452
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.86725776
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86704379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000678_abnormal_parathyroid_gland4.06560936
2MP0002877_abnormal_melanocyte_morpholog3.88332350
3MP0002837_dystrophic_cardiac_calcinosis3.32973135
4MP0001188_hyperpigmentation3.25238954
5MP0003283_abnormal_digestive_organ3.20050281
6MP0005379_endocrine/exocrine_gland_phen3.11423710
7MP0002693_abnormal_pancreas_physiology3.08533067
8MP0009379_abnormal_foot_pigmentation3.07767245
9MP0001944_abnormal_pancreas_morphology2.95013863
10MP0005409_darkened_coat_color2.77584493
11MP0000579_abnormal_nail_morphology2.73628582
12MP0000566_synostosis2.52548743
13MP0010386_abnormal_urinary_bladder2.38486729
14MP0009780_abnormal_chondrocyte_physiolo2.37698682
15MP0002234_abnormal_pharynx_morphology2.28853098
16MP0004043_abnormal_pH_regulation2.19984019
17MP0000013_abnormal_adipose_tissue2.17394168
18MP0001986_abnormal_taste_sensitivity2.14441751
19MP0001346_abnormal_lacrimal_gland2.13510920
20MP0002098_abnormal_vibrissa_morphology2.13239618
21MP0003195_calcinosis2.06854201
22MP0004885_abnormal_endolymph2.06565253
23MP0004381_abnormal_hair_follicle2.00247538
24MP0003941_abnormal_skin_development1.97870874
25MP0009046_muscle_twitch1.97403839
26MP0002822_catalepsy1.93785527
27MP0000613_abnormal_salivary_gland1.93315589
28MP0006292_abnormal_olfactory_placode1.91950352
29MP0003136_yellow_coat_color1.86671325
30MP0003183_abnormal_peptide_metabolism1.82225326
31MP0000383_abnormal_hair_follicle1.81847995
32MP0000681_abnormal_thyroid_gland1.77525576
33MP0002876_abnormal_thyroid_physiology1.77211772
34MP0005220_abnormal_exocrine_pancreas1.74899859
35MP0002177_abnormal_outer_ear1.74388563
36MP0003121_genomic_imprinting1.73063090
37MP0008877_abnormal_DNA_methylation1.72046464
38MP0002896_abnormal_bone_mineralization1.72042744
39MP0000762_abnormal_tongue_morphology1.64645573
40MP0001984_abnormal_olfaction1.63534234
41MP0004133_heterotaxia1.63236547
42MP0003123_paternal_imprinting1.63029209
43MP0005645_abnormal_hypothalamus_physiol1.62580541
44MP0002928_abnormal_bile_duct1.60757360
45MP0000467_abnormal_esophagus_morphology1.58581796
46MP0001756_abnormal_urination1.57385335
47MP0001270_distended_abdomen1.56349701
48* MP0002909_abnormal_adrenal_gland1.55968784
49MP0010234_abnormal_vibrissa_follicle1.49466014
50MP0000049_abnormal_middle_ear1.47360978
51MP0002796_impaired_skin_barrier1.47318632
52MP0002638_abnormal_pupillary_reflex1.43961041
53MP0002938_white_spotting1.43748648
54MP0010678_abnormal_skin_adnexa1.43477352
55MP0002254_reproductive_system_inflammat1.38884439
56MP0004264_abnormal_extraembryonic_tissu1.37668893
57MP0004019_abnormal_vitamin_homeostasis1.36990120
58MP0006072_abnormal_retinal_apoptosis1.34080333
59MP0004145_abnormal_muscle_electrophysio1.33873703
60MP0001765_abnormal_ion_homeostasis1.33537006
61MP0005332_abnormal_amino_acid1.29413965
62MP0000462_abnormal_digestive_system1.28322368
63MP0000538_abnormal_urinary_bladder1.27165421
64MP0002249_abnormal_larynx_morphology1.25385832
65MP0005253_abnormal_eye_physiology1.24161212
66MP0005551_abnormal_eye_electrophysiolog1.23898938
67MP0002557_abnormal_social/conspecific_i1.21892683
68MP0003011_delayed_dark_adaptation1.20494561
69MP0003868_abnormal_feces_composition1.20351051
70MP0002163_abnormal_gland_morphology1.19826669
71MP0005646_abnormal_pituitary_gland1.18465419
72MP0002060_abnormal_skin_morphology1.17055650
73MP0000647_abnormal_sebaceous_gland1.16458982
74MP0002078_abnormal_glucose_homeostasis1.15276652
75MP0005448_abnormal_energy_balance1.14691926
76MP0001501_abnormal_sleep_pattern1.13535578
77* MP0000631_abnormal_neuroendocrine_gland1.11442224
78MP0005377_hearing/vestibular/ear_phenot1.10553496
79MP0003878_abnormal_ear_physiology1.10553496
80MP0010329_abnormal_lipoprotein_level1.10518492
81MP0009745_abnormal_behavioral_response1.09211823
82MP0005084_abnormal_gallbladder_morpholo1.08359277
83MP0000003_abnormal_adipose_tissue1.07412722
84MP0001919_abnormal_reproductive_system1.07113514
85MP0005275_abnormal_skin_tensile1.07036974
86MP0001485_abnormal_pinna_reflex1.05565142
87MP0002272_abnormal_nervous_system1.04987291
88MP0000428_abnormal_craniofacial_morphol1.03932000
89MP0005075_abnormal_melanosome_morpholog1.03499567
90MP0005257_abnormal_intraocular_pressure1.03311536
91MP0000015_abnormal_ear_pigmentation1.02856083
92MP0000163_abnormal_cartilage_morphology1.01692223
93MP0005174_abnormal_tail_pigmentation1.00985806
94MP0005248_abnormal_Harderian_gland1.00681550
95MP0002572_abnormal_emotion/affect_behav0.99160047
96MP0002064_seizures0.98905285
97MP0002009_preneoplasia0.98110345
98MP0000516_abnormal_urinary_system0.97436053
99MP0005367_renal/urinary_system_phenotyp0.97436053
100MP0003787_abnormal_imprinting0.95388806
101MP0002116_abnormal_craniofacial_bone0.93819013
102MP0003045_fibrosis0.92897008
103MP0009250_abnormal_appendicular_skeleto0.91564053
104MP0008789_abnormal_olfactory_epithelium0.91298267
105MP0004924_abnormal_behavior0.90618030
106MP0005386_behavior/neurological_phenoty0.90618030
107MP0003755_abnormal_palate_morphology0.90541534
108MP0002095_abnormal_skin_pigmentation0.90363072
109MP0000427_abnormal_hair_cycle0.89988681
110MP0003890_abnormal_embryonic-extraembry0.89403382
111MP0000377_abnormal_hair_follicle0.89076328
112MP0001216_abnormal_epidermal_layer0.88536654
113MP0003385_abnormal_body_wall0.87475468
114MP0002229_neurodegeneration0.86950400
115MP0002734_abnormal_mechanical_nocicepti0.86903132
116MP0005636_abnormal_mineral_homeostasis0.86899837
117MP0001970_abnormal_pain_threshold0.86819450
118MP0002295_abnormal_pulmonary_circulatio0.86740804
119MP0000639_abnormal_adrenal_gland0.86718549
120MP0002102_abnormal_ear_morphology0.86682082
121MP0001529_abnormal_vocalization0.85788493
122MP0003172_abnormal_lysosome_physiology0.85494285
123MP0002090_abnormal_vision0.84197269
124MP0002233_abnormal_nose_morphology0.84140276
125MP0006276_abnormal_autonomic_nervous0.83870399
126MP0003122_maternal_imprinting0.83758056
127MP0010030_abnormal_orbit_morphology0.83697864
128MP0005365_abnormal_bile_salt0.83687455
129MP0004270_analgesia0.83640929
130MP0002184_abnormal_innervation0.83497621
131MP0003300_gastrointestinal_ulcer0.83354849
132MP0003953_abnormal_hormone_level0.82213944
133MP0001905_abnormal_dopamine_level0.81879870
134MP0003879_abnormal_hair_cell0.81619660
135MP0000470_abnormal_stomach_morphology0.81494946
136MP0005508_abnormal_skeleton_morphology0.81241170
137MP0002069_abnormal_eating/drinking_beha0.78043495
138MP0010771_integument_phenotype0.77160370
139MP0004142_abnormal_muscle_tone0.77131946
140MP0003935_abnormal_craniofacial_develop0.77105318
141MP0002751_abnormal_autonomic_nervous0.76182212
142MP0001502_abnormal_circadian_rhythm0.75506372
143MP0000026_abnormal_inner_ear0.75206737
144MP0001299_abnormal_eye_distance/0.74901667
145MP0002277_abnormal_respiratory_mucosa0.74475600
146MP0002063_abnormal_learning/memory/cond0.71746597
147MP0001968_abnormal_touch/_nociception0.71478037
148MP0001666_abnormal_nutrient_absorption0.69783284
149MP0008961_abnormal_basal_metabolism0.69454606
150MP0002138_abnormal_hepatobiliary_system0.69245687
151MP0003119_abnormal_digestive_system0.68948699
152MP0002733_abnormal_thermal_nociception0.68806796
153MP0005501_abnormal_skin_physiology0.68527161
154MP0003635_abnormal_synaptic_transmissio0.66876907
155MP0001186_pigmentation_phenotype0.66262998
156MP0001340_abnormal_eyelid_morphology0.65587375

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.34115512
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.10266570
3Symptomatic seizures (HP:0011145)4.47491283
4Decreased circulating renin level (HP:0003351)4.46660217
5Hypoglycemic seizures (HP:0002173)4.46339734
6Insulin-resistant diabetes mellitus (HP:0000831)4.26205529
7Abnormality of calcium-phosphate metabolism (HP:0100530)4.12479743
8Onycholysis (HP:0001806)3.82296803
9Double outlet right ventricle (HP:0001719)3.71281542
10Congenital malformation of the right heart (HP:0011723)3.71281542
11Milia (HP:0001056)3.48156412
12Hyperphosphatemia (HP:0002905)3.36096565
13Fragile nails (HP:0001808)3.29120735
14Abnormality of renin-angiotensin system (HP:0000847)3.20691711
15Hypothermia (HP:0002045)3.20316441
16Hyperglycemia (HP:0003074)3.16370277
17Hypokalemia (HP:0002900)3.13869652
18Ketosis (HP:0001946)3.11030894
19Large for gestational age (HP:0001520)3.10471680
20Hyperkalemia (HP:0002153)3.09702381
21EEG with generalized epileptiform discharges (HP:0011198)3.07361969
22Pancreatic islet-cell hyperplasia (HP:0004510)3.05818619
23Hypomagnesemia (HP:0002917)3.05686231
24Absent eyebrow (HP:0002223)3.05375077
25Epileptiform EEG discharges (HP:0011182)3.01271489
26Hyperparathyroidism (HP:0000843)2.98343966
27Osteomalacia (HP:0002749)2.97837096
28Abnormal pancreas size (HP:0012094)2.93049323
29Amelogenesis imperfecta (HP:0000705)2.91079097
30Hypsarrhythmia (HP:0002521)2.90111662
31Enlarged penis (HP:0000040)2.88189727
32Hypoglycemic coma (HP:0001325)2.86576395
33Abnormality of potassium homeostasis (HP:0011042)2.86148900
34Type I transferrin isoform profile (HP:0003642)2.85040407
35Mucopolysacchariduria (HP:0008155)2.83032023
36Urinary glycosaminoglycan excretion (HP:0003541)2.83032023
37Intestinal atresia (HP:0011100)2.80632593
38Lip pit (HP:0100267)2.79932816
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.69797221
40Abnormality of polysaccharide metabolism (HP:0011012)2.69797221
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.69797221
42Congenital sensorineural hearing impairment (HP:0008527)2.69453537
43Atrophic scars (HP:0001075)2.68615707
44Popliteal pterygium (HP:0009756)2.64991124
45Pancreatic cysts (HP:0001737)2.61017559
46True hermaphroditism (HP:0010459)2.60970450
47Agitation (HP:0000713)2.59200511
48Type I diabetes mellitus (HP:0100651)2.56778704
49Plantar hyperkeratosis (HP:0007556)2.54705514
50Nephronophthisis (HP:0000090)2.53225060
51Abnormality of the pancreatic islet cells (HP:0006476)2.49886508
52Abnormality of endocrine pancreas physiology (HP:0012093)2.49886508
53Dysostosis multiplex (HP:0000943)2.49707654
54Hypoplastic labia majora (HP:0000059)2.47906590
55Molar tooth sign on MRI (HP:0002419)2.45197096
56Abnormality of midbrain morphology (HP:0002418)2.45197096
57Late onset (HP:0003584)2.43183269
58Hyperactive renin-angiotensin system (HP:0000841)2.40754057
59Cystic liver disease (HP:0006706)2.40406749
60Dry hair (HP:0011359)2.39977669
61Hypotrichosis (HP:0001006)2.39678777
62Ridged nail (HP:0001807)2.38814533
63Conjunctival hamartoma (HP:0100780)2.37637490
64Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35775750
65Hemiparesis (HP:0001269)2.35583299
66Abnormality of the neuromuscular junction (HP:0003398)2.33068510
67Fatigable weakness (HP:0003473)2.33068510
68Abnormality of the renal cortex (HP:0011035)2.31132590
69Hypoplasia of dental enamel (HP:0006297)2.30173218
70Abnormal drinking behavior (HP:0030082)2.29941636
71Polydipsia (HP:0001959)2.29941636
72Proximal tubulopathy (HP:0000114)2.28900886
73Abnormal glycosylation (HP:0012345)2.28674773
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28674773
75Abnormal protein N-linked glycosylation (HP:0012347)2.28674773
76Abnormal protein glycosylation (HP:0012346)2.28674773
77Furrowed tongue (HP:0000221)2.28474634
78Decreased lacrimation (HP:0000633)2.24888071
79Bronchomalacia (HP:0002780)2.21528048
8011 pairs of ribs (HP:0000878)2.21419196
81Menstrual irregularities (HP:0000858)2.20928380
82Abnormality of the labia majora (HP:0012881)2.20906174
83Medial flaring of the eyebrow (HP:0010747)2.20107849
84Polyphagia (HP:0002591)2.19944744
85Obstructive sleep apnea (HP:0002870)2.18196306
86Split foot (HP:0001839)2.17401052
87Abnormality of the renal medulla (HP:0100957)2.16341682
88Abnormality of vitamin B metabolism (HP:0004340)2.16217796
89Hypoplasia of the uterus (HP:0000013)2.15316806
90Cortical visual impairment (HP:0100704)2.12663155
91Aqueductal stenosis (HP:0002410)2.11201177
92Neoplasm of the adrenal cortex (HP:0100641)2.10660755
93Progressive macrocephaly (HP:0004481)2.09832729
94Chronic bronchitis (HP:0004469)2.09673214
95Abnormality of urine glucose concentration (HP:0011016)2.07321002
96Glycosuria (HP:0003076)2.07321002
97Hepatic necrosis (HP:0002605)2.06798658
98Cutaneous finger syndactyly (HP:0010554)2.06426848
99Increased IgE level (HP:0003212)2.03275205
100Aplasia/Hypoplasia of the fovea (HP:0008060)2.01999109
101Hypoplasia of the fovea (HP:0007750)2.01999109
102Woolly hair (HP:0002224)1.98899830
103Congenital glaucoma (HP:0001087)1.98476929
104Tubular atrophy (HP:0000092)1.98248633
105Natal tooth (HP:0000695)1.97622230
106Hamartoma of the eye (HP:0010568)1.95747033
107Acute necrotizing encephalopathy (HP:0006965)1.95694022
108Increased circulating renin level (HP:0000848)1.94255566
109Abnormality of magnesium homeostasis (HP:0004921)1.94104499
110Hyperaldosteronism (HP:0000859)1.93925439
111Downturned corners of mouth (HP:0002714)1.93534891
112Muscular hypotonia of the trunk (HP:0008936)1.92719199
113Pili torti (HP:0003777)1.92414407
114Generalized aminoaciduria (HP:0002909)1.92070036
115Pancreatic fibrosis (HP:0100732)1.91909709
116Insulin resistance (HP:0000855)1.91608804
117Testicular neoplasm (HP:0010788)1.91397376
118Limb dystonia (HP:0002451)1.85193630
119Hypoalbuminemia (HP:0003073)1.84169525
120Abnormal albumin level (HP:0012116)1.84169525
121Mixed hearing impairment (HP:0000410)1.83201660
122Mitochondrial inheritance (HP:0001427)1.83165403
123Tongue fasciculations (HP:0001308)1.82124608
124Gait imbalance (HP:0002141)1.82064697
125Prominent metopic ridge (HP:0005487)1.81599796
126Cutaneous syndactyly (HP:0012725)1.81574696
127Hypokinesia (HP:0002375)1.81372874
128Anhidrosis (HP:0000970)1.80941602
129Gaze-evoked nystagmus (HP:0000640)1.80275155
130Renal cortical cysts (HP:0000803)1.79984031
131Hyperventilation (HP:0002883)1.79042910
132Absent eyelashes (HP:0000561)1.78631302
133Median cleft lip (HP:0000161)1.78315754
134Labial hypoplasia (HP:0000066)1.78240926
135Abnormality of chloride homeostasis (HP:0011422)1.77948039
136Broad nasal tip (HP:0000455)1.77725980
137Hyperthyroidism (HP:0000836)1.77634656
138Congenital stationary night blindness (HP:0007642)1.76817185
139Widely spaced teeth (HP:0000687)1.76749251
140Congenital, generalized hypertrichosis (HP:0004540)1.76586659
141Increased CSF protein (HP:0002922)1.76268990
142Abdominal situs inversus (HP:0003363)1.75413280
143Abnormality of abdominal situs (HP:0011620)1.75413280
144Abdominal distention (HP:0003270)1.73274877
145Missing ribs (HP:0000921)1.72726368
146Palmar hyperkeratosis (HP:0010765)1.71149621
147Methylmalonic acidemia (HP:0002912)1.70975181
148Congenital primary aphakia (HP:0007707)1.70716428
149Arthropathy (HP:0003040)1.69890533
150Tracheomalacia (HP:0002779)1.69689923
151Disproportionate short-trunk short stature (HP:0003521)1.69485413
152Abnormality of the fovea (HP:0000493)1.69299781
153Hypodontia (HP:0000668)1.68497699
154Right ventricular cardiomyopathy (HP:0011663)1.68470865
155Abnormality of the metopic suture (HP:0005556)1.67936974
156Abnormality of vitamin metabolism (HP:0100508)1.67921900
157Postural tremor (HP:0002174)1.67271685
158Retinal atrophy (HP:0001105)1.67127003
159Ketoacidosis (HP:0001993)1.66696129
160Alacrima (HP:0000522)1.65706962
161Thoracolumbar scoliosis (HP:0002944)1.65562322
162Palmoplantar hyperkeratosis (HP:0000972)1.65451686
163Poor suck (HP:0002033)1.64564165
164Genital tract atresia (HP:0001827)1.63202427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.17732587
2INSRR5.57327952
3PASK3.72954783
4FGFR23.63126649
5TAOK33.53115596
6IRAK33.00450057
7PHKG22.91899730
8PHKG12.91899730
9CASK2.73907289
10HIPK22.63896643
11MAP3K22.57766386
12TNIK2.37609094
13IRAK12.35680971
14MAP4K22.18193539
15DAPK22.12524688
16MAP3K42.00984459
17STK38L1.94530538
18FRK1.92503180
19MAP3K11.89473847
20MAP3K121.87801497
21ACVR1B1.81258179
22NLK1.80150804
23MAP2K61.69310369
24FGFR31.54611885
25WNK41.54391421
26FER1.47978487
27STK241.43182788
28PRKD21.41837310
29NTRK31.41485760
30ZAK1.40078000
31PRKD31.38483434
32TRPM71.37034143
33AKT31.34269461
34EPHA31.33239690
35EPHA21.26920335
36STK391.20385984
37CSNK1G11.19071412
38MAP2K21.18893701
39BMPR1B1.17236848
40IRAK21.17162163
41IRAK41.15988638
42MAP3K31.13855333
43MKNK21.13137732
44MAP3K91.12877817
45UHMK11.11373805
46STK31.10598718
47CAMKK21.10547675
48BMPR21.05078335
49MUSK1.04969208
50CDK31.04754144
51EPHB21.03952630
52CSNK1G30.99406560
53NEK60.98829523
54CDC42BPA0.97072613
55PIK3CG0.96462732
56WNK30.96304029
57MAP2K40.96273764
58PRKCG0.94474964
59CSNK1G20.94389263
60PINK10.93018658
61STK110.91292008
62OXSR10.88314321
63TAOK10.85929895
64DYRK20.81475275
65PRKCH0.80256268
66STK160.79789975
67PRKCE0.79228719
68TGFBR10.77630797
69ERN10.77444331
70MAP2K70.75713660
71ERBB30.75015322
72DYRK1B0.72603553
73PRKAA10.70273580
74ADRBK20.68377267
75PLK20.67897057
76PTK60.67334888
77MARK10.66153588
78PRKAA20.64317039
79PTK20.64223358
80NME10.62445770
81NUAK10.62206461
82RPS6KA20.61888256
83PRKCI0.56319880
84GRK10.55981712
85MST1R0.55854464
86YES10.55143914
87SGK20.54674977
88TEC0.54082163
89CAMK10.53624103
90WNK10.52328978
91PTK2B0.50950524
92MET0.49912661
93CAMK2D0.49592207
94CHUK0.49354152
95EIF2AK30.48365422
96BTK0.48096816
97MAP3K140.47656769
98CAMK2B0.45291037
99LATS10.44541902
100PNCK0.43673933
101BRSK20.43060953
102CSNK1D0.42808082
103STK380.41278403
104MARK20.41240492
105MAPK130.39570541
106CSNK1A10.39407352
107FGFR10.39099897
108FLT30.38384717
109MST40.38200492
110PRKACA0.38102873
111ADRBK10.37433451
112CAMK1G0.37346813
113VRK10.36026167
114NTRK20.35779399
115TLK10.35171049
116PDGFRA0.33762776
117PRKD10.33638063
118MAP3K70.32192713
119CSNK1A1L0.32170423
120PRKG20.31876239
121PRKG10.31793091
122BRD40.31352036
123SGK2230.31299776
124SGK4940.31299776
125SGK10.29634876
126TIE10.29229834
127MAPKAPK30.29196623
128JAK20.27709841
129PRKCA0.27686012
130GSK3A0.27151157
131ERBB20.26296809
132CAMK2A0.25674802
133PRPF4B0.25560163
134DYRK1A0.25315306
135RPS6KL10.25017773
136RPS6KC10.25017773
137GRK50.24845735
138CDK90.24826058
139PAK30.24805141
140TNK20.24297247
141MAPK70.24266581

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.32577114
2Protein export_Homo sapiens_hsa030604.40803606
3Insulin secretion_Homo sapiens_hsa049112.99995951
4Oxidative phosphorylation_Homo sapiens_hsa001902.44037550
5Butanoate metabolism_Homo sapiens_hsa006502.42534332
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.10483295
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06868245
8Type I diabetes mellitus_Homo sapiens_hsa049401.81454216
9Other glycan degradation_Homo sapiens_hsa005111.79564413
10Sulfur metabolism_Homo sapiens_hsa009201.77939002
11Type II diabetes mellitus_Homo sapiens_hsa049301.75025830
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65259084
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63779849
14Sphingolipid metabolism_Homo sapiens_hsa006001.58009691
15Taste transduction_Homo sapiens_hsa047421.55598403
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.53996294
17Cocaine addiction_Homo sapiens_hsa050301.53465200
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50332384
19N-Glycan biosynthesis_Homo sapiens_hsa005101.48424274
20Folate biosynthesis_Homo sapiens_hsa007901.45562916
21Tryptophan metabolism_Homo sapiens_hsa003801.43867057
22Pancreatic secretion_Homo sapiens_hsa049721.41442058
23Parkinsons disease_Homo sapiens_hsa050121.38752779
24Amphetamine addiction_Homo sapiens_hsa050311.33135252
25Vitamin B6 metabolism_Homo sapiens_hsa007501.31470718
26Vibrio cholerae infection_Homo sapiens_hsa051101.31110530
27Circadian rhythm_Homo sapiens_hsa047101.28929007
28Fatty acid elongation_Homo sapiens_hsa000621.24106457
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23726574
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21226903
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19641333
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16823599
33Cardiac muscle contraction_Homo sapiens_hsa042601.15220823
34Selenocompound metabolism_Homo sapiens_hsa004501.14339672
35Alzheimers disease_Homo sapiens_hsa050101.12321262
36Serotonergic synapse_Homo sapiens_hsa047261.11853562
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10078003
38Lysosome_Homo sapiens_hsa041421.04718165
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04568454
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03467313
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03179551
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01791963
43Protein digestion and absorption_Homo sapiens_hsa049741.01528559
44Mineral absorption_Homo sapiens_hsa049781.01411054
45Peroxisome_Homo sapiens_hsa041461.00971558
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98101851
47Ovarian steroidogenesis_Homo sapiens_hsa049130.97279152
48Arachidonic acid metabolism_Homo sapiens_hsa005900.94547599
49ABC transporters_Homo sapiens_hsa020100.92691922
50Linoleic acid metabolism_Homo sapiens_hsa005910.92354932
51Cholinergic synapse_Homo sapiens_hsa047250.92044819
52Nicotine addiction_Homo sapiens_hsa050330.89467527
53Huntingtons disease_Homo sapiens_hsa050160.89315851
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88811033
55* Melanogenesis_Homo sapiens_hsa049160.88256343
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88144580
57Thyroid hormone synthesis_Homo sapiens_hsa049180.87477133
58Propanoate metabolism_Homo sapiens_hsa006400.87089321
59Circadian entrainment_Homo sapiens_hsa047130.85349341
60Retinol metabolism_Homo sapiens_hsa008300.85233235
61beta-Alanine metabolism_Homo sapiens_hsa004100.84742685
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84322538
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83134902
64Prolactin signaling pathway_Homo sapiens_hsa049170.80363061
65Thyroid cancer_Homo sapiens_hsa052160.78907093
66Fatty acid metabolism_Homo sapiens_hsa012120.77480423
67Renin secretion_Homo sapiens_hsa049240.77073514
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76690416
69* Basal cell carcinoma_Homo sapiens_hsa052170.75620587
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.74979430
71* Wnt signaling pathway_Homo sapiens_hsa043100.74715622
72* Hedgehog signaling pathway_Homo sapiens_hsa043400.73539082
73Prostate cancer_Homo sapiens_hsa052150.73341693
74Dopaminergic synapse_Homo sapiens_hsa047280.72774013
75Morphine addiction_Homo sapiens_hsa050320.71785500
76Long-term depression_Homo sapiens_hsa047300.71711248
77Chemical carcinogenesis_Homo sapiens_hsa052040.71436654
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70779340
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69520290
80Nitrogen metabolism_Homo sapiens_hsa009100.69476385
81Estrogen signaling pathway_Homo sapiens_hsa049150.68418462
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68241675
83Fatty acid degradation_Homo sapiens_hsa000710.68017872
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67597697
85ECM-receptor interaction_Homo sapiens_hsa045120.67155220
86cAMP signaling pathway_Homo sapiens_hsa040240.67062117
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66824568
88Long-term potentiation_Homo sapiens_hsa047200.66811864
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63332342
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.61597495
91Caffeine metabolism_Homo sapiens_hsa002320.60837612
92Glutathione metabolism_Homo sapiens_hsa004800.60583341
93Regulation of autophagy_Homo sapiens_hsa041400.60439546
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60261398
95GnRH signaling pathway_Homo sapiens_hsa049120.59069569
96Glutamatergic synapse_Homo sapiens_hsa047240.57933355
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57365603
98Glucagon signaling pathway_Homo sapiens_hsa049220.56737224
99Calcium signaling pathway_Homo sapiens_hsa040200.56596255
100Metabolic pathways_Homo sapiens_hsa011000.56361496
101Phototransduction_Homo sapiens_hsa047440.56003676
102Fat digestion and absorption_Homo sapiens_hsa049750.55393600
103Insulin resistance_Homo sapiens_hsa049310.53943704
104Salivary secretion_Homo sapiens_hsa049700.52358541
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51647934
106GABAergic synapse_Homo sapiens_hsa047270.50770852
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50657480
108Bladder cancer_Homo sapiens_hsa052190.50455711
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49793305
110Gastric acid secretion_Homo sapiens_hsa049710.48580549
111Histidine metabolism_Homo sapiens_hsa003400.47798743
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.47701376
113Ether lipid metabolism_Homo sapiens_hsa005650.47523339
114Amoebiasis_Homo sapiens_hsa051460.46429191
115Rheumatoid arthritis_Homo sapiens_hsa053230.45962204
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44951493
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42938477
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42662461
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42305622
120Ras signaling pathway_Homo sapiens_hsa040140.41618628
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41470685
122Notch signaling pathway_Homo sapiens_hsa043300.41034126
123Starch and sucrose metabolism_Homo sapiens_hsa005000.40901761
124Dorso-ventral axis formation_Homo sapiens_hsa043200.40384270
125Gap junction_Homo sapiens_hsa045400.37297598
126* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36239178
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33872960
128Olfactory transduction_Homo sapiens_hsa047400.33555195
129Axon guidance_Homo sapiens_hsa043600.32532889
130MAPK signaling pathway_Homo sapiens_hsa040100.32497017
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.32432399
132TNF signaling pathway_Homo sapiens_hsa046680.32405602
133Alcoholism_Homo sapiens_hsa050340.31969233
134Endometrial cancer_Homo sapiens_hsa052130.31482031
135Collecting duct acid secretion_Homo sapiens_hsa049660.31282816
136Prion diseases_Homo sapiens_hsa050200.31215340
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31067194
138Synaptic vesicle cycle_Homo sapiens_hsa047210.30288170
139Melanoma_Homo sapiens_hsa052180.29991524
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29588833
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.29463020

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