WNT5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endodermal cell differentiation (GO:0035987)5.19323585
2bone trabecula formation (GO:0060346)5.12408638
3cell proliferation involved in metanephros development (GO:0072203)5.10250223
4axon extension involved in axon guidance (GO:0048846)5.10088031
5neuron projection extension involved in neuron projection guidance (GO:1902284)5.10088031
6skin morphogenesis (GO:0043589)4.95110896
7extracellular matrix assembly (GO:0085029)4.88367094
8regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.85155668
9mesenchymal cell proliferation (GO:0010463)4.76903805
10chondrocyte proliferation (GO:0035988)4.67021421
11paraxial mesoderm development (GO:0048339)4.63822732
12* lateral sprouting from an epithelium (GO:0060601)4.55667779
13craniofacial suture morphogenesis (GO:0097094)4.52095760
14endocardial cushion development (GO:0003197)4.48616480
15* planar cell polarity pathway involved in neural tube closure (GO:0090179)4.44520713
16sequestering of extracellular ligand from receptor (GO:0035581)4.42027599
17type B pancreatic cell proliferation (GO:0044342)4.39651453
18regulation of integrin-mediated signaling pathway (GO:2001044)4.36869010
19G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.33796871
20cell proliferation involved in kidney development (GO:0072111)4.28912101
21outer ear morphogenesis (GO:0042473)4.21100946
22* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.21037250
23cell adhesion mediated by integrin (GO:0033627)4.15580748
24epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.09871441
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.08958024
26embryonic forelimb morphogenesis (GO:0035115)4.08337963
27negative regulation of smooth muscle cell migration (GO:0014912)4.05606646
28prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.95812200
29hippo signaling (GO:0035329)3.93016951
30mesenchyme morphogenesis (GO:0072132)3.92559499
31pericardium development (GO:0060039)3.92338016
32collagen metabolic process (GO:0032963)3.88041800
33cranial suture morphogenesis (GO:0060363)3.86941115
34cell migration involved in sprouting angiogenesis (GO:0002042)3.84023742
35regulation of mesenchymal cell apoptotic process (GO:2001053)3.82401726
36regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.81560696
37radial glial cell differentiation (GO:0060019)3.80907483
38hindlimb morphogenesis (GO:0035137)3.80865827
39collagen fibril organization (GO:0030199)3.80475065
40negative regulation of catenin import into nucleus (GO:0035414)3.78084190
41forelimb morphogenesis (GO:0035136)3.77703517
42chondrocyte development (GO:0002063)3.75790720
43negative regulation of chondrocyte differentiation (GO:0032331)3.74276864
44collagen catabolic process (GO:0030574)3.70807377
45cell migration involved in heart development (GO:0060973)3.67233713
46embryonic hindlimb morphogenesis (GO:0035116)3.66849235
47regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.63383509
48glomerular filtration (GO:0003094)3.62295952
49embryonic cranial skeleton morphogenesis (GO:0048701)3.62102881
50multicellular organismal macromolecule metabolic process (GO:0044259)3.58696154
51branching involved in prostate gland morphogenesis (GO:0060442)3.56225524
52artery development (GO:0060840)3.54977512
53dermatan sulfate biosynthetic process (GO:0030208)3.53997371
54embryonic skeletal joint morphogenesis (GO:0060272)3.52154952
55endocardial cushion morphogenesis (GO:0003203)3.50871070
56regulation of metalloenzyme activity (GO:0048552)3.48871656
57positive regulation of blood vessel endothelial cell migration (GO:0043536)3.48112065
58regulation of non-canonical Wnt signaling pathway (GO:2000050)3.46970859
59substrate-dependent cell migration (GO:0006929)3.44627646
60proximal/distal pattern formation (GO:0009954)3.43761661
61positive regulation of fibroblast migration (GO:0010763)3.43101649
62positive regulation of epithelial to mesenchymal transition (GO:0010718)3.42802145
63heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.41935222
64multicellular organismal metabolic process (GO:0044236)3.39423161
65head development (GO:0060322)3.39143472
66multicellular organismal catabolic process (GO:0044243)3.38530507
67lung-associated mesenchyme development (GO:0060484)3.35229607
68axis elongation (GO:0003401)3.34499888
69wound healing, spreading of epidermal cells (GO:0035313)3.34135566
70embryonic appendage morphogenesis (GO:0035113)3.33035112
71embryonic limb morphogenesis (GO:0030326)3.33035112
72positive regulation of smoothened signaling pathway (GO:0045880)3.32815432
73* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.32733865
74limb morphogenesis (GO:0035108)3.32713141
75appendage morphogenesis (GO:0035107)3.32713141
76extracellular fibril organization (GO:0043206)3.32443082
77* negative regulation of axon extension involved in axon guidance (GO:0048843)3.30627153
78neural crest cell development (GO:0014032)3.29501485
79dermatan sulfate metabolic process (GO:0030205)3.28844623
80extracellular matrix disassembly (GO:0022617)3.28696304
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.28201578
82prostate gland epithelium morphogenesis (GO:0060740)3.27776999
83* mesenchymal-epithelial cell signaling (GO:0060638)3.27726746
84renal filtration (GO:0097205)3.26436542
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26151101
86branching involved in salivary gland morphogenesis (GO:0060445)3.26030435
87* regulation of establishment of planar polarity (GO:0090175)3.23938494
88limb bud formation (GO:0060174)3.23857863
89vascular endothelial growth factor signaling pathway (GO:0038084)3.23421026
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22766860
91smooth muscle tissue development (GO:0048745)3.22272529
92mesodermal cell differentiation (GO:0048333)3.19735046
93substrate adhesion-dependent cell spreading (GO:0034446)3.19326491
94cellular response to vitamin (GO:0071295)3.19143822
95branch elongation of an epithelium (GO:0060602)3.15061494
96negative regulation of cartilage development (GO:0061037)3.13439409
97mesenchyme development (GO:0060485)3.12317661
98regulation of heart morphogenesis (GO:2000826)3.11225151
99middle ear morphogenesis (GO:0042474)3.11158318
100* establishment of planar polarity (GO:0001736)3.08526145
101* establishment of tissue polarity (GO:0007164)3.08526145
102notochord development (GO:0030903)3.08013027
103* negative regulation of embryonic development (GO:0045992)3.06623643
104cartilage morphogenesis (GO:0060536)3.03652784
105extracellular matrix organization (GO:0030198)3.03540852
106mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.03373375
107* cochlea morphogenesis (GO:0090103)3.02721163
108extracellular structure organization (GO:0043062)3.02529459
109virion attachment to host cell (GO:0019062)3.02501327
110adhesion of symbiont to host cell (GO:0044650)3.02501327
111cardiac epithelial to mesenchymal transition (GO:0060317)3.01673658
112positive regulation of gastrulation (GO:2000543)3.01133869
113metanephric mesenchyme development (GO:0072075)3.01013978
114establishment of nucleus localization (GO:0040023)3.00786160
115* cell surface receptor signaling pathway involved in heart development (GO:0061311)3.00552882
116regulation of chondrocyte differentiation (GO:0032330)3.00050651
117dorsal/ventral axis specification (GO:0009950)2.99071756
118heparan sulfate proteoglycan metabolic process (GO:0030201)2.98849398
119negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.98299102
120positive regulation of astrocyte differentiation (GO:0048711)2.97939544
121extracellular negative regulation of signal transduction (GO:1900116)2.96462477
122extracellular regulation of signal transduction (GO:1900115)2.96462477
123somite development (GO:0061053)2.95798141
124* non-canonical Wnt signaling pathway (GO:0035567)2.94368254
125kidney mesenchyme development (GO:0072074)2.92568398
126endothelial cell morphogenesis (GO:0001886)2.92345717
127negative regulation of nitric-oxide synthase activity (GO:0051001)2.92254309
128* regulation of mesenchymal cell proliferation (GO:0010464)2.91878331
129* negative chemotaxis (GO:0050919)2.91755154
130anatomical structure regression (GO:0060033)2.91653811
131* positive regulation of mesenchymal cell proliferation (GO:0002053)2.91268191
132protein heterotrimerization (GO:0070208)2.90722392
133* dopaminergic neuron differentiation (GO:0071542)2.90707130
134* embryonic digit morphogenesis (GO:0042733)2.90186811
135* negative regulation of BMP signaling pathway (GO:0030514)2.90173363
136* epithelial to mesenchymal transition (GO:0001837)2.89742548
137positive regulation of endothelial cell apoptotic process (GO:2000353)2.89277152
138mesenchymal cell development (GO:0014031)2.89027728
139* regulation of organ formation (GO:0003156)2.88823457
140glomerular basement membrane development (GO:0032836)2.88292823
141lymphangiogenesis (GO:0001946)2.87390728
142* negative regulation of axon guidance (GO:1902668)2.85817072
143fibril organization (GO:0097435)2.85349364
144insulin-like growth factor receptor signaling pathway (GO:0048009)2.85086861
145regulation of plasminogen activation (GO:0010755)2.84821911
146cellular response to vitamin D (GO:0071305)2.84656406
147mesenchymal cell differentiation (GO:0048762)2.84060347
148face morphogenesis (GO:0060325)2.83543454
149branching involved in ureteric bud morphogenesis (GO:0001658)2.83363403
150muscle cell migration (GO:0014812)2.83270874
151regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.82921638
152sprouting angiogenesis (GO:0002040)2.82465707
153artery morphogenesis (GO:0048844)2.82237523
154embryonic foregut morphogenesis (GO:0048617)2.82048963
155basement membrane organization (GO:0071711)2.81350223
156organ formation (GO:0048645)2.81045436
157eyelid development in camera-type eye (GO:0061029)2.80699080
158apoptotic cell clearance (GO:0043277)2.80502464
159tooth mineralization (GO:0034505)2.78602060
160protein localization to cell surface (GO:0034394)2.76633850
161negative regulation of fatty acid transport (GO:2000192)2.74750994
162endocrine hormone secretion (GO:0060986)2.73525494
163atrioventricular valve morphogenesis (GO:0003181)2.73521793
164positive regulation of osteoblast proliferation (GO:0033690)2.71260145
165blood vessel maturation (GO:0001955)2.70158490
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67375828
167negative regulation of osteoblast proliferation (GO:0033689)2.67202736
168regulation of smooth muscle cell migration (GO:0014910)2.67162034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.41170832
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.83354524
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.35964675
4* EED_16625203_ChIP-ChIP_MESCs_Mouse3.13564943
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09389979
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.08345436
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.91025726
8* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.86717813
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.68852362
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55087196
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55087196
12EZH2_22144423_ChIP-Seq_EOC_Human2.50439864
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.48477661
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46250482
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.44600305
16* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.43837618
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43780163
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40954810
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.29522359
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27493213
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24812598
22* TP53_20018659_ChIP-ChIP_R1E_Mouse2.22095891
23* CBX2_27304074_Chip-Seq_ESCs_Mouse2.21015842
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20425586
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.15099304
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09286797
27* RNF2_27304074_Chip-Seq_ESCs_Mouse2.03844974
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.03816638
29* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99414219
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.95831726
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95255329
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91232881
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90712579
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86220538
35* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85018410
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82550569
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77155167
38TP53_18474530_ChIP-ChIP_U2OS_Human1.76634777
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76454733
40* ISL1_27105846_Chip-Seq_CPCs_Mouse1.75647134
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74319881
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.73734460
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71253640
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.64191728
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62069420
46GBX2_23144817_ChIP-Seq_PC3_Human1.54836744
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.53589759
48* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52324944
49MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.50282186
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48685403
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48561825
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48088996
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46639973
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44672391
55* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44206577
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41289550
57* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41199900
58* EZH2_27294783_Chip-Seq_ESCs_Mouse1.39580604
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39100891
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39100891
61* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38491818
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38427307
63* CJUN_26792858_Chip-Seq_BT549_Human1.35273719
64* SA1_22415368_ChIP-Seq_MEFs_Mouse1.34309946
65* BRD4_25478319_ChIP-Seq_HGPS_Human1.33208302
66* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31117686
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30496301
68* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28308849
69* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28260641
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27648260
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27084145
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.26516087
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26328161
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25722273
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.23203538
76AR_21572438_ChIP-Seq_LNCaP_Human1.22053974
77* UBF1/2_26484160_Chip-Seq_HMECs_Human1.20224245
78* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19392436
79AR_21909140_ChIP-Seq_LNCAP_Human1.19362948
80EWS_26573619_Chip-Seq_HEK293_Human1.18483328
81FUS_26573619_Chip-Seq_HEK293_Human1.18189702
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17998831
83ZNF274_21170338_ChIP-Seq_K562_Hela1.16622928
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15900994
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15713256
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15284538
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15181719
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15098761
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11571618
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11177169
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10192796
92RNF2_27304074_Chip-Seq_NSC_Mouse1.09903534
93* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09771008
94* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09771008
95AHR_22903824_ChIP-Seq_MCF-7_Human1.09687263
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09478999
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.09380938
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08920907
99* P300_19829295_ChIP-Seq_ESCs_Human1.08559672
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.07831687
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07150963
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.07024167
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.06299143
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06211627
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05165001
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03488941
107ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03306916
108* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03252305
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02987332
110* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02109150
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01752832
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.01334194
113* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99815155
114SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99806202
115TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99740811
116* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99499431
117TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99412121
118* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98923844
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98909477
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97539228
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.97213731
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96457717
123TP53_16413492_ChIP-PET_HCT116_Human0.96400889
124* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96138206
125CLOCK_20551151_ChIP-Seq_293T_Human0.95418102
126BCAT_22108803_ChIP-Seq_LS180_Human0.94303057
127* SMAD4_21799915_ChIP-Seq_A2780_Human0.93975116
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92675167
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92291165
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.92279429
131RXR_22108803_ChIP-Seq_LS180_Human0.91496226
132AR_19668381_ChIP-Seq_PC3_Human0.91386398
133SOX2_20726797_ChIP-Seq_SW620_Human0.91007846
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90587916
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89659267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.12268664
2MP0005503_abnormal_tendon_morphology4.03224984
3MP0000537_abnormal_urethra_morphology3.35212205
4MP0010030_abnormal_orbit_morphology3.32749201
5* MP0009053_abnormal_anal_canal3.27499162
6MP0000566_synostosis3.20844029
7MP0003385_abnormal_body_wall2.96743282
8MP0009250_abnormal_appendicular_skeleto2.96668798
9MP0003122_maternal_imprinting2.92548567
10MP0003950_abnormal_plasma_membrane2.74975350
11MP0005275_abnormal_skin_tensile2.64207650
12MP0001542_abnormal_bone_strength2.50437092
13MP0002938_white_spotting2.34076007
14MP0003937_abnormal_limbs/digits/tail_de2.29646319
15* MP0003942_abnormal_urinary_system2.29353587
16MP0000049_abnormal_middle_ear2.20613684
17MP0000534_abnormal_ureter_morphology2.10494047
18MP0003941_abnormal_skin_development2.10312050
19MP0004272_abnormal_basement_membrane2.10031118
20MP0003566_abnormal_cell_adhesion2.00506182
21MP0000428_abnormal_craniofacial_morphol1.97620143
22* MP0002932_abnormal_joint_morphology1.95596984
23MP0005508_abnormal_skeleton_morphology1.92728235
24MP0003755_abnormal_palate_morphology1.90450760
25MP0005187_abnormal_penis_morphology1.89204595
26MP0002249_abnormal_larynx_morphology1.87809024
27MP0005023_abnormal_wound_healing1.87421315
28MP0003283_abnormal_digestive_organ1.84908650
29MP0001299_abnormal_eye_distance/1.83902264
30* MP0002282_abnormal_trachea_morphology1.81509189
31MP0009384_cardiac_valve_regurgitation1.80600040
32MP0003705_abnormal_hypodermis_morpholog1.79471987
33MP0003121_genomic_imprinting1.77549374
34MP0003935_abnormal_craniofacial_develop1.73318198
35MP0003123_paternal_imprinting1.69760555
36MP0005257_abnormal_intraocular_pressure1.67631121
37MP0002233_abnormal_nose_morphology1.66072813
38MP0009780_abnormal_chondrocyte_physiolo1.65808671
39MP0005248_abnormal_Harderian_gland1.64686261
40* MP0002116_abnormal_craniofacial_bone1.63078892
41MP0000516_abnormal_urinary_system1.62913280
42MP0005367_renal/urinary_system_phenotyp1.62913280
43MP0003279_aneurysm1.61980610
44MP0005623_abnormal_meninges_morphology1.57354808
45* MP0003115_abnormal_respiratory_system1.56359381
46MP0001293_anophthalmia1.56282219
47MP0001958_emphysema1.50608180
48* MP0002109_abnormal_limb_morphology1.47478743
49MP0010352_gastrointestinal_tract_polyps1.46959497
50MP0005171_absent_coat_pigmentation1.45342302
51MP0000163_abnormal_cartilage_morphology1.43275397
52MP0002108_abnormal_muscle_morphology1.43240404
53MP0003315_abnormal_perineum_morphology1.40601495
54* MP0000762_abnormal_tongue_morphology1.39927707
55MP0000733_abnormal_muscle_development1.39237326
56* MP0000432_abnormal_head_morphology1.39201585
57MP0003938_abnormal_ear_development1.38916350
58MP0006054_spinal_hemorrhage1.35384552
59* MP0002115_abnormal_skeleton_extremities1.34486948
60MP0005595_abnormal_vascular_smooth1.28164584
61MP0000751_myopathy1.26582799
62MP0003119_abnormal_digestive_system1.25216174
63MP0000569_abnormal_digit_pigmentation1.23291863
64MP0000383_abnormal_hair_follicle1.21778233
65MP0001879_abnormal_lymphatic_vessel1.21537081
66MP0000579_abnormal_nail_morphology1.18724979
67MP0002234_abnormal_pharynx_morphology1.18547525
68MP0010386_abnormal_urinary_bladder1.17162437
69MP0000767_abnormal_smooth_muscle1.17046213
70* MP0002113_abnormal_skeleton_development1.11936860
71* MP0002177_abnormal_outer_ear1.11596797
72MP0004134_abnormal_chest_morphology1.10599899
73MP0002697_abnormal_eye_size1.08054515
74MP0002896_abnormal_bone_mineralization1.07630347
75* MP0002114_abnormal_axial_skeleton1.07089155
76MP0002102_abnormal_ear_morphology1.07034220
77MP0000462_abnormal_digestive_system1.05113288
78MP0000013_abnormal_adipose_tissue1.04053204
79MP0001286_abnormal_eye_development1.03799656
80MP0002098_abnormal_vibrissa_morphology1.02525912
81* MP0002111_abnormal_tail_morphology1.01377875
82MP0004858_abnormal_nervous_system0.99246090
83MP0001340_abnormal_eyelid_morphology0.99197958
84MP0001348_abnormal_lacrimal_gland0.95066432
85MP0005076_abnormal_cell_differentiation0.93612035
86MP0001346_abnormal_lacrimal_gland0.93148195
87MP0002092_abnormal_eye_morphology0.91660496
88MP0000778_abnormal_nervous_system0.90930142
89MP0005164_abnormal_response_to0.86966381
90MP0002089_abnormal_postnatal_growth/wei0.86520237
91MP0001270_distended_abdomen0.86001526
92* MP0002085_abnormal_embryonic_tissue0.85972693
93MP0010678_abnormal_skin_adnexa0.85067235
94MP0003861_abnormal_nervous_system0.83172135
95MP0004233_abnormal_muscle_weight0.81393868
96MP0002128_abnormal_blood_circulation0.81321103
97MP0000467_abnormal_esophagus_morphology0.80974363
98MP0003448_altered_tumor_morphology0.80889488
99MP0000647_abnormal_sebaceous_gland0.80761378
100MP0000749_muscle_degeneration0.80427603
101MP0002060_abnormal_skin_morphology0.80260233
102MP0003091_abnormal_cell_migration0.79255845
103MP0002751_abnormal_autonomic_nervous0.78609505
104MP0002925_abnormal_cardiovascular_devel0.77770341
105MP0010368_abnormal_lymphatic_system0.76485910
106* MP0002084_abnormal_developmental_patter0.75551918
107MP0004197_abnormal_fetal_growth/weight/0.75303442
108MP0000750_abnormal_muscle_regeneration0.74959335
109MP0002653_abnormal_ependyma_morphology0.73467099
110* MP0002081_perinatal_lethality0.73395013
111MP0009703_decreased_birth_body0.73362094
112MP0005388_respiratory_system_phenotype0.72982596
113MP0002133_abnormal_respiratory_system0.72982596
114MP0002295_abnormal_pulmonary_circulatio0.72072478
115MP0005197_abnormal_uvea_morphology0.71949051
116MP0008789_abnormal_olfactory_epithelium0.70531511
117MP0000613_abnormal_salivary_gland0.70453599
118MP0003567_abnormal_fetal_cardiomyocyte0.70283371
119MP0005390_skeleton_phenotype0.69855608
120MP0001614_abnormal_blood_vessel0.69836399
121MP0001243_abnormal_dermal_layer0.69751779
122MP0005193_abnormal_anterior_eye0.68661944
123MP0000759_abnormal_skeletal_muscle0.67564460
124MP0008775_abnormal_heart_ventricle0.66788122
125MP0002168_other_aberrant_phenotype0.66182225
126MP0004084_abnormal_cardiac_muscle0.63377247
127MP0001849_ear_inflammation0.58391650
128* MP0001175_abnormal_lung_morphology0.56653214
129MP0001915_intracranial_hemorrhage0.55166395
130MP0008004_abnormal_stomach_pH0.52835050
131MP0002254_reproductive_system_inflammat0.52566193
132MP0005620_abnormal_muscle_contractility0.48625958
133MP0003795_abnormal_bone_structure0.48052050
134MP0004883_abnormal_blood_vessel0.47110250
135MP0001177_atelectasis0.46352396
136MP0000003_abnormal_adipose_tissue0.45238612

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.99640356
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.99640356
3Protrusio acetabuli (HP:0003179)4.52900691
4Abnormality of the 4th metacarpal (HP:0010012)4.48258836
5Shallow orbits (HP:0000586)4.18991913
6Type 1 muscle fiber predominance (HP:0003803)4.18659077
7Premature rupture of membranes (HP:0001788)4.06873161
8Abnormality of the parietal bone (HP:0002696)3.86361653
9Cervical subluxation (HP:0003308)3.66801934
10Slender build (HP:0001533)3.57160228
11Spondylolisthesis (HP:0003302)3.52124736
12Wormian bones (HP:0002645)3.46045533
13Coronal craniosynostosis (HP:0004440)3.39558985
14Spinal rigidity (HP:0003306)3.26933477
15Broad metatarsal (HP:0001783)3.24991889
16Aortic dissection (HP:0002647)3.19731705
17Midline defect of the nose (HP:0004122)3.18376020
18* Blue sclerae (HP:0000592)3.10917069
19Bowel diverticulosis (HP:0005222)3.07331934
20Abnormality of the phalanges of the hallux (HP:0010057)3.01147890
21Hyperextensible skin (HP:0000974)2.81894938
22Soft skin (HP:0000977)2.76592058
23Deviation of the hallux (HP:0010051)2.74912983
24Biconcave vertebral bodies (HP:0004586)2.74241175
25Overgrowth (HP:0001548)2.68023347
26Morphological abnormality of the middle ear (HP:0008609)2.65468244
27Microglossia (HP:0000171)2.64904462
28Elbow flexion contracture (HP:0002987)2.63929153
29Cutaneous finger syndactyly (HP:0010554)2.60732976
30Abnormality of the 2nd finger (HP:0004100)2.59460520
31Aortic aneurysm (HP:0004942)2.59311428
32Abnormality of the distal phalanx of the thumb (HP:0009617)2.58672633
33Abnormal delivery (HP:0001787)2.57750430
34Ankle contracture (HP:0006466)2.56877102
35Aortic regurgitation (HP:0001659)2.54582495
36Mildly elevated creatine phosphokinase (HP:0008180)2.53403077
37Bladder diverticulum (HP:0000015)2.51365694
38Preaxial foot polydactyly (HP:0001841)2.49993967
39Trigonocephaly (HP:0000243)2.49902544
40Concave nail (HP:0001598)2.48105187
41Atrophic scars (HP:0001075)2.46968928
42Hallux valgus (HP:0001822)2.44727676
43* Broad toe (HP:0001837)2.43881089
44Hepatoblastoma (HP:0002884)2.37606704
45Hypoventilation (HP:0002791)2.37037084
46Neonatal short-limb short stature (HP:0008921)2.36373529
47Osteolytic defects of the hand bones (HP:0009699)2.36366973
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.36366973
49Spinal cord lesions (HP:0100561)2.36014151
50Syringomyelia (HP:0003396)2.36014151
51Increased variability in muscle fiber diameter (HP:0003557)2.33695534
52Abnormality of dentin (HP:0010299)2.33587898
53Broad hallux (HP:0010055)2.32053422
54Bell-shaped thorax (HP:0001591)2.31431231
55Vertebral compression fractures (HP:0002953)2.31315134
56Aplasia of the musculature (HP:0100854)2.30477813
57* Wide anterior fontanel (HP:0000260)2.30197534
58Abnormality of the middle phalanges of the toes (HP:0010183)2.30099606
59Abnormality of the acetabulum (HP:0003170)2.28654174
60Abnormality of the nasolacrimal system (HP:0000614)2.28530436
61Cutaneous syndactyly (HP:0012725)2.28320929
62Follicular hyperkeratosis (HP:0007502)2.27097213
63Mitral regurgitation (HP:0001653)2.25577293
64Mild short stature (HP:0003502)2.25178969
65Camptodactyly of toe (HP:0001836)2.24387467
66Partial duplication of the phalanx of hand (HP:0009999)2.22196820
67Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19430177
68Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.17256304
69Ectopia lentis (HP:0001083)2.16583449
70Ulnar bowing (HP:0003031)2.12693561
71Buphthalmos (HP:0000557)2.11811011
72Aortic valve stenosis (HP:0001650)2.11480577
73Absent frontal sinuses (HP:0002688)2.10917793
74Anophthalmia (HP:0000528)2.09482610
75Bilateral microphthalmos (HP:0007633)2.09322345
76Dilatation of the ascending aorta (HP:0005111)2.08467300
77Short hallux (HP:0010109)2.07426256
78Knee flexion contracture (HP:0006380)2.06625629
79Asymmetry of the thorax (HP:0001555)2.04955224
80Narrow nasal bridge (HP:0000446)2.04371599
81Turricephaly (HP:0000262)2.04217696
82Short clavicles (HP:0000894)2.04094131
83Deformed tarsal bones (HP:0008119)2.04022926
84* Broad long bones (HP:0005622)2.03946873
85Mitral valve prolapse (HP:0001634)2.02773436
86Calcaneovalgus deformity (HP:0001848)2.02366098
87Delayed gross motor development (HP:0002194)2.02084921
88Aneurysm (HP:0002617)2.00572882
89Fragile skin (HP:0001030)1.99733859
90Aplasia/Hypoplasia of the clavicles (HP:0006710)1.98574843
91Short phalanx of the thumb (HP:0009660)1.97951815
92Protruding ear (HP:0000411)1.97656421
93* Broad thumb (HP:0011304)1.97346422
94Tarsal synostosis (HP:0008368)1.97320349
95Delayed cranial suture closure (HP:0000270)1.96360266
96Vascular tortuosity (HP:0004948)1.96335818
97Abnormal number of incisors (HP:0011064)1.96254840
98* Short 5th finger (HP:0009237)1.95816945
99Short nail (HP:0001799)1.95707135
100Synostosis of carpal bones (HP:0005048)1.95476922
101Round ear (HP:0100830)1.95116902
102Hypoplasia of the iris (HP:0007676)1.94663203
103Exostoses (HP:0100777)1.94095592
104Arterial tortuosity (HP:0005116)1.94060871
105Delayed closure of the anterior fontanelle (HP:0001476)1.94042851
106Redundant skin (HP:0001582)1.93835862
107Absent phalangeal crease (HP:0006109)1.93053651
108Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.92717062
109Broad ribs (HP:0000885)1.92356480
110Keratoconus (HP:0000563)1.91568351
111Increased corneal curvature (HP:0100692)1.91568351
112Disproportionate tall stature (HP:0001519)1.90386308
113* Short middle phalanx of the 5th finger (HP:0004220)1.90125616
114Abnormal umbilical cord blood vessels (HP:0011403)1.89262721
115Single umbilical artery (HP:0001195)1.89262721
116Abnormality of the fetal cardiovascular system (HP:0010948)1.89262721
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88800733
118Synostosis involving bones of the feet (HP:0009140)1.88192919
119Synostosis involving bones of the lower limbs (HP:0009138)1.88192919
120Peritonitis (HP:0002586)1.87106346
121Abnormality of the nasal septum (HP:0000419)1.86715176
122Cerebral aneurysm (HP:0004944)1.85769224
123* Mesomelia (HP:0003027)1.85579483
124Natal tooth (HP:0000695)1.85259497
125* Broad phalanx (HP:0006009)1.85067674
126Flared iliac wings (HP:0002869)1.84714622
127* Renal duplication (HP:0000075)1.84596140
128Short 1st metacarpal (HP:0010034)1.84373137
129Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84373137
130Generalized amyotrophy (HP:0003700)1.84118274
131Abnormality of the lacrimal duct (HP:0011481)1.83927663
132Nonimmune hydrops fetalis (HP:0001790)1.83890888
133Cupped ribs (HP:0000887)1.83540842
134Genu recurvatum (HP:0002816)1.83492624
135Aplasia/Hypoplasia of the hallux (HP:0008362)1.82594667
136Carpal synostosis (HP:0009702)1.82452607
137Abnormality of skeletal muscle fiber size (HP:0012084)1.82385479
138* Inguinal hernia (HP:0000023)1.82247975
139Breech presentation (HP:0001623)1.81778804
140* Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81672235
141Abnormality of skull ossification (HP:0002703)1.81509469
142Wrist flexion contracture (HP:0001239)1.80836154
143Abnormality of the umbilical cord (HP:0010881)1.80611636
144Decreased skull ossification (HP:0004331)1.80415671
145Joint laxity (HP:0001388)1.79778640
146Bifid scrotum (HP:0000048)1.79759116
147Broad distal phalanx of finger (HP:0009836)1.79453943
148Aplasia involving bones of the extremities (HP:0009825)1.79397463
149Aplasia involving bones of the upper limbs (HP:0009823)1.79397463
150Aplasia of the phalanges of the hand (HP:0009802)1.79397463
151Limb-girdle muscle weakness (HP:0003325)1.79303747
152Short metatarsal (HP:0010743)1.78589667
153Congenital glaucoma (HP:0001087)1.78041087
154* Broad finger (HP:0001500)1.77885325
155Hypoplasia of the maxilla (HP:0000327)1.77815883
156Supernumerary ribs (HP:0005815)1.77479605
157Femoral bowing (HP:0002980)1.77282470
158Osteoarthritis (HP:0002758)1.77025831
159Down-sloping shoulders (HP:0200021)1.76690169
160* Broad phalanges of the hand (HP:0009768)1.76689822
161Infantile muscular hypotonia (HP:0008947)1.76501680
162Aplasia cutis congenita (HP:0001057)1.76476617
163Abnormality of the radial head (HP:0003995)1.76410944
164Vitreoretinal degeneration (HP:0000655)1.76225153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.74129167
2LATS14.70234468
3DDR24.30581448
4PDGFRA3.36517686
5LATS23.33248535
6FGFR22.79552632
7ERBB32.28228443
8PNCK2.15241366
9TTN2.10149018
10SIK12.05215676
11FGFR12.00144679
12NTRK11.99267881
13KSR11.95363621
14PIK3CG1.94025021
15MKNK11.91149685
16PRKD21.88332465
17STK38L1.87786921
18DMPK1.72024036
19FLT31.68599148
20FER1.66282041
21SIK31.65301729
22STK31.63975216
23MAP3K101.59379212
24PAK21.55899197
25ERBB21.52477316
26EPHA31.48342521
27PAK31.48092605
28CDK81.47542694
29MUSK1.41178890
30CAMK1G1.39947213
31CDK121.34342442
32MOS1.30594484
33CAMK1D1.28199924
34TRIB31.27506007
35NUAK11.27185860
36PIK3CA1.25448903
37GRK71.24518931
38BRD41.19322800
39MAP3K31.18868936
40PLK21.08054262
41TGFBR11.05996162
42CDC42BPA1.03601027
43MKNK21.02562409
44RIPK11.01776206
45PTK21.01645942
46PAK41.01639231
47ROCK10.98271769
48BRSK20.98028719
49NEK90.96945640
50PDGFRB0.95993514
51EIF2AK30.95844396
52PTK60.94758341
53TRIM280.94628642
54MELK0.93288802
55ABL20.93184393
56MYLK0.90430256
57MTOR0.90280692
58CASK0.89509404
59BCR0.86543381
60KIT0.85572792
61PLK30.83246733
62GSK3A0.81501722
63RPS6KA40.79402694
64AKT30.78710936
65UHMK10.77627512
66PTK2B0.74183474
67PRKD30.71709709
68CSNK1A1L0.70686860
69ICK0.67408622
70CDK70.66835160
71WEE10.65894595
72TYRO30.61527967
73ZAK0.60774879
74LMTK20.60284033
75ADRBK20.59964939
76BMPR1B0.59323934
77LIMK10.59261342
78BMX0.58775193
79JAK10.58360884
80ROCK20.57372696
81WNK10.55980631
82MAP2K10.55797262
83DYRK20.54255898
84RPS6KA20.53661361
85PKN20.53616145
86MAPK70.53101232
87CSNK1G10.52284145
88AKT20.51898987
89CDK60.51363209
90NEK10.48943343
91MINK10.48567535
92DAPK30.48374361
93TAOK20.48193635
94ADRBK10.46986587
95YES10.46554075
96TRPM70.46361287
97TGFBR20.44852116
98ERBB40.43763396
99STK240.43419323
100GRK10.43414053
101BRSK10.43306049
102EIF2AK10.43152621
103MAPK130.43038810
104MET0.42572952
105PRKCE0.42348995
106ERN10.42255611
107PRKG20.41670885
108SRC0.41032522
109AKT10.40884332
110FRK0.40771680
111GRK50.39786391
112CDK90.38988347
113MAP3K60.38970534
114FGFR30.38063849
115CAMK40.36788440
116PRKCH0.36310561
117ACVR1B0.36155356
118CDK10.35335651
119PIM20.35107029
120DYRK1B0.34966074
121PBK0.33948940
122INSR0.33679135
123ILK0.32792323
124PAK10.32694699
125DYRK30.32664004
126SRPK10.32651952
127ABL10.31931350
128PAK60.30720365
129IGF1R0.30051395
130TAF10.29916073
131CAMK2G0.29263068
132STK380.28960959
133MAPK10.28697839
134CHEK20.28468203
135PRKD10.26961241
136ATR0.26710705
137CDK140.26426270
138TESK10.25503745
139CHUK0.25421614
140MAPKAPK20.22656741
141STK390.22558848
142MAP3K120.18882447
143CAMK2D0.17293974

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052174.60489419
2* Hedgehog signaling pathway_Homo sapiens_hsa043403.70943897
3* Hippo signaling pathway_Homo sapiens_hsa043903.18802377
4ECM-receptor interaction_Homo sapiens_hsa045123.09178863
5TGF-beta signaling pathway_Homo sapiens_hsa043502.82916490
6* Wnt signaling pathway_Homo sapiens_hsa043102.51125820
7Adherens junction_Homo sapiens_hsa045202.47540126
8Axon guidance_Homo sapiens_hsa043602.32217810
9Focal adhesion_Homo sapiens_hsa045102.28766635
10* Proteoglycans in cancer_Homo sapiens_hsa052052.26067616
11* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.20497827
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.09099267
13MicroRNAs in cancer_Homo sapiens_hsa052062.06079398
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.89904126
15Notch signaling pathway_Homo sapiens_hsa043301.87722254
16Dilated cardiomyopathy_Homo sapiens_hsa054141.75832823
17Protein digestion and absorption_Homo sapiens_hsa049741.74793811
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74619548
19* Melanogenesis_Homo sapiens_hsa049161.72934202
20Melanoma_Homo sapiens_hsa052181.72465647
21* Pathways in cancer_Homo sapiens_hsa052001.62630337
22Small cell lung cancer_Homo sapiens_hsa052221.59058307
23Prostate cancer_Homo sapiens_hsa052151.57884700
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54352013
25Colorectal cancer_Homo sapiens_hsa052101.50772458
26Protein export_Homo sapiens_hsa030601.48521873
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44924209
28Cell cycle_Homo sapiens_hsa041101.40809528
29Bladder cancer_Homo sapiens_hsa052191.37407000
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36806876
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36799136
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33587005
33Endometrial cancer_Homo sapiens_hsa052131.29015006
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.27299055
35Chronic myeloid leukemia_Homo sapiens_hsa052201.23653885
36Tight junction_Homo sapiens_hsa045301.23067958
37Sulfur metabolism_Homo sapiens_hsa009201.20203837
38Viral myocarditis_Homo sapiens_hsa054161.19591652
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19348452
40* HTLV-I infection_Homo sapiens_hsa051661.16493337
41Amoebiasis_Homo sapiens_hsa051461.13788542
42Rap1 signaling pathway_Homo sapiens_hsa040151.12759169
43Glioma_Homo sapiens_hsa052141.10242774
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01929915
45Lysine degradation_Homo sapiens_hsa003100.97471334
46p53 signaling pathway_Homo sapiens_hsa041150.96225824
47Prion diseases_Homo sapiens_hsa050200.94436869
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92363925
49Renal cell carcinoma_Homo sapiens_hsa052110.89734067
50Mineral absorption_Homo sapiens_hsa049780.88800503
51Gap junction_Homo sapiens_hsa045400.88778497
52Complement and coagulation cascades_Homo sapiens_hsa046100.88502389
53Pancreatic cancer_Homo sapiens_hsa052120.85510596
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85368591
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84222259
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80077659
57Ovarian steroidogenesis_Homo sapiens_hsa049130.79747551
58Shigellosis_Homo sapiens_hsa051310.79545155
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.76161903
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74037749
61Thyroid cancer_Homo sapiens_hsa052160.72713041
62ErbB signaling pathway_Homo sapiens_hsa040120.70755452
63mRNA surveillance pathway_Homo sapiens_hsa030150.70027176
64Ras signaling pathway_Homo sapiens_hsa040140.66966444
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66196538
66Malaria_Homo sapiens_hsa051440.65611682
67Oocyte meiosis_Homo sapiens_hsa041140.64540583
68Spliceosome_Homo sapiens_hsa030400.64465228
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61102290
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.61059706
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59102157
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58057592
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.57854638
74FoxO signaling pathway_Homo sapiens_hsa040680.57834856
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57674925
76Estrogen signaling pathway_Homo sapiens_hsa049150.56260678
77Vibrio cholerae infection_Homo sapiens_hsa051100.54044896
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53987262
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52498459
80cAMP signaling pathway_Homo sapiens_hsa040240.52107816
81Cocaine addiction_Homo sapiens_hsa050300.51300198
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50187135
83HIF-1 signaling pathway_Homo sapiens_hsa040660.50063986
84Pertussis_Homo sapiens_hsa051330.49412683
85Non-small cell lung cancer_Homo sapiens_hsa052230.48608747
86MAPK signaling pathway_Homo sapiens_hsa040100.48588059
87Calcium signaling pathway_Homo sapiens_hsa040200.48009360
88Hepatitis B_Homo sapiens_hsa051610.47827863
89Endocytosis_Homo sapiens_hsa041440.47629771
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47339008
91Renin secretion_Homo sapiens_hsa049240.46142322
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45701080
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.45055293
94Dorso-ventral axis formation_Homo sapiens_hsa043200.44917017
95Renin-angiotensin system_Homo sapiens_hsa046140.43939879
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43828727
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42308422
98GnRH signaling pathway_Homo sapiens_hsa049120.42098259
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41879294
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41287928
101Thyroid hormone synthesis_Homo sapiens_hsa049180.40200150
102Long-term depression_Homo sapiens_hsa047300.39617432
103Phagosome_Homo sapiens_hsa041450.38639641
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37854851
105mTOR signaling pathway_Homo sapiens_hsa041500.37602307
106AMPK signaling pathway_Homo sapiens_hsa041520.35570181
107N-Glycan biosynthesis_Homo sapiens_hsa005100.34729530
108Salmonella infection_Homo sapiens_hsa051320.34663167
109Choline metabolism in cancer_Homo sapiens_hsa052310.34446690
110Oxytocin signaling pathway_Homo sapiens_hsa049210.33264449
111RNA transport_Homo sapiens_hsa030130.32930017
112Circadian entrainment_Homo sapiens_hsa047130.32511682
113TNF signaling pathway_Homo sapiens_hsa046680.32443615
114Selenocompound metabolism_Homo sapiens_hsa004500.31702987
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.31380285
116Dopaminergic synapse_Homo sapiens_hsa047280.30657119
117Viral carcinogenesis_Homo sapiens_hsa052030.30608174
118Sphingolipid metabolism_Homo sapiens_hsa006000.30598335
119Platelet activation_Homo sapiens_hsa046110.30390599
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29629025
121Lysosome_Homo sapiens_hsa041420.27642208
122Glutathione metabolism_Homo sapiens_hsa004800.27508527
123African trypanosomiasis_Homo sapiens_hsa051430.26818939
124Toxoplasmosis_Homo sapiens_hsa051450.25442919
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23235906

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