WNT5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.97512826
2endodermal cell differentiation (GO:0035987)5.58614710
3skin morphogenesis (GO:0043589)5.47317136
4bone trabecula formation (GO:0060346)5.40171305
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.93608511
6virion attachment to host cell (GO:0019062)4.75507145
7adhesion of symbiont to host cell (GO:0044650)4.75507145
8chondrocyte proliferation (GO:0035988)4.74310342
9sequestering of extracellular ligand from receptor (GO:0035581)4.67506026
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.65929723
11L-phenylalanine metabolic process (GO:0006558)4.65929723
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.55267047
13L-phenylalanine catabolic process (GO:0006559)4.55267047
14cell adhesion mediated by integrin (GO:0033627)4.49749456
15kidney mesenchyme development (GO:0072074)4.45107275
16cellular response to vitamin (GO:0071295)4.31569701
17negative regulation of cholesterol transport (GO:0032375)4.29956418
18negative regulation of sterol transport (GO:0032372)4.29956418
19alpha-linolenic acid metabolic process (GO:0036109)4.29849964
20cell migration involved in heart development (GO:0060973)4.29743939
21extracellular matrix assembly (GO:0085029)4.29297307
22dopaminergic neuron differentiation (GO:0071542)4.17228365
23lung epithelium development (GO:0060428)4.16815460
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.15505745
25negative regulation of fibrinolysis (GO:0051918)4.12892238
26substrate-dependent cell migration (GO:0006929)4.10579335
27protein retention in ER lumen (GO:0006621)4.09412598
28aromatic amino acid family catabolic process (GO:0009074)4.07595028
29mesenchymal-epithelial cell signaling (GO:0060638)4.04790348
30collagen metabolic process (GO:0032963)4.02215558
31midgut development (GO:0007494)3.98872873
32adhesion of symbiont to host (GO:0044406)3.98755947
33kynurenine metabolic process (GO:0070189)3.96002074
34glyoxylate metabolic process (GO:0046487)3.92364027
35endocardial cushion development (GO:0003197)3.90847787
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.90160747
37heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.84928595
38collagen catabolic process (GO:0030574)3.81603969
39epoxygenase P450 pathway (GO:0019373)3.80363896
40lysine metabolic process (GO:0006553)3.74919231
41lysine catabolic process (GO:0006554)3.74919231
42regulation of fibrinolysis (GO:0051917)3.72491612
43paraxial mesoderm development (GO:0048339)3.71656420
44multicellular organismal macromolecule metabolic process (GO:0044259)3.68329106
45triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.67968748
46peptidyl-glutamic acid carboxylation (GO:0017187)3.67435930
47protein carboxylation (GO:0018214)3.67435930
48tryptophan catabolic process (GO:0006569)3.65558240
49indole-containing compound catabolic process (GO:0042436)3.65558240
50indolalkylamine catabolic process (GO:0046218)3.65558240
51cellular response to vitamin D (GO:0071305)3.64613736
52positive regulation of blood vessel endothelial cell migration (GO:0043536)3.64000853
53glycine metabolic process (GO:0006544)3.63054497
54cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.60573006
55cell migration involved in sprouting angiogenesis (GO:0002042)3.57854954
56sulfur amino acid catabolic process (GO:0000098)3.53786595
57tryptophan metabolic process (GO:0006568)3.51552443
58serine family amino acid catabolic process (GO:0009071)3.49159950
59cell proliferation involved in metanephros development (GO:0072203)3.49039806
60extracellular fibril organization (GO:0043206)3.47818669
61axon extension involved in axon guidance (GO:0048846)3.47574440
62neuron projection extension involved in neuron projection guidance (GO:1902284)3.47574440
63cell-substrate junction assembly (GO:0007044)3.46936954
64multicellular organismal metabolic process (GO:0044236)3.45811415
65negative regulation of smooth muscle cell migration (GO:0014912)3.45697286
66regulation of protein activation cascade (GO:2000257)3.45462403
67multicellular organismal catabolic process (GO:0044243)3.44719535
68bile acid biosynthetic process (GO:0006699)3.41877800
69metanephric mesenchyme development (GO:0072075)3.41768322
70primitive streak formation (GO:0090009)3.39153596
71mesodermal cell differentiation (GO:0048333)3.38017549
72branching involved in salivary gland morphogenesis (GO:0060445)3.37603161
73stress fiber assembly (GO:0043149)3.35938717
74tooth mineralization (GO:0034505)3.34817109
75wound healing, spreading of epidermal cells (GO:0035313)3.33834572
76type B pancreatic cell proliferation (GO:0044342)3.33504558
77Golgi transport vesicle coating (GO:0048200)3.33149218
78COPI coating of Golgi vesicle (GO:0048205)3.33149218
79Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31881935
80G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.30073670
81extracellular matrix disassembly (GO:0022617)3.29000062
82homocysteine metabolic process (GO:0050667)3.27577349
83urea cycle (GO:0000050)3.27358631
84urea metabolic process (GO:0019627)3.27358631
85negative regulation of chondrocyte differentiation (GO:0032331)3.27101006
86regulation of complement activation (GO:0030449)3.26221130
87negative regulation of axon extension involved in axon guidance (GO:0048843)3.25286593
88notochord development (GO:0030903)3.24038285
89muscle cell migration (GO:0014812)3.22375076
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.22307716
91protein localization to endosome (GO:0036010)3.21041291
92actin filament depolymerization (GO:0030042)3.20717656
93basement membrane organization (GO:0071711)3.20407245
94apoptotic cell clearance (GO:0043277)3.19002862
95complement activation, alternative pathway (GO:0006957)3.18421979
96positive regulation of axon extension (GO:0045773)3.17693513
974-hydroxyproline metabolic process (GO:0019471)3.17562150
98regulation of plasminogen activation (GO:0010755)3.16974818
99cellular glucuronidation (GO:0052695)3.16406055
100regulation of establishment of planar polarity (GO:0090175)3.15467017
101extracellular regulation of signal transduction (GO:1900115)3.12023575
102extracellular negative regulation of signal transduction (GO:1900116)3.12023575
103cochlea morphogenesis (GO:0090103)3.11719230
104embryonic foregut morphogenesis (GO:0048617)3.11354049
105hemidesmosome assembly (GO:0031581)3.10357762
106high-density lipoprotein particle remodeling (GO:0034375)3.09338978
107cysteine metabolic process (GO:0006534)3.08921490
108planar cell polarity pathway involved in neural tube closure (GO:0090179)3.08806730
109positive regulation of extracellular matrix organization (GO:1903055)3.07204986
110hypotonic response (GO:0006971)3.06856116
111barbed-end actin filament capping (GO:0051016)3.06720358
112negative regulation of osteoblast proliferation (GO:0033689)3.05141974
113negative regulation of nitric-oxide synthase activity (GO:0051001)3.04531255
114wound healing, spreading of cells (GO:0044319)3.04100824
115heparan sulfate proteoglycan metabolic process (GO:0030201)3.03032438
116venous blood vessel morphogenesis (GO:0048845)3.03023726
117acylglycerol homeostasis (GO:0055090)3.02958039
118triglyceride homeostasis (GO:0070328)3.02958039
119serine family amino acid metabolic process (GO:0009069)3.01891145
120mesenchymal cell proliferation (GO:0010463)3.00019242
121serine family amino acid biosynthetic process (GO:0009070)2.99974730
122regulation of mesoderm development (GO:2000380)2.98270114
123regulation of fatty acid beta-oxidation (GO:0031998)2.97666376
124axon extension (GO:0048675)2.97345776
125alpha-amino acid catabolic process (GO:1901606)2.96109945
126negative regulation of BMP signaling pathway (GO:0030514)2.96041603
127extracellular matrix organization (GO:0030198)2.95549782
128fibril organization (GO:0097435)2.95475087
129extracellular structure organization (GO:0043062)2.94366539
130adherens junction assembly (GO:0034333)2.93682838
131regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.93123926
132negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.92953482
133aromatic amino acid family metabolic process (GO:0009072)2.92339955
134cellular modified amino acid catabolic process (GO:0042219)2.91820558
135vascular endothelial growth factor signaling pathway (GO:0038084)2.90454213
136negative regulation of embryonic development (GO:0045992)2.90315973
137regulation of cholesterol homeostasis (GO:2000188)2.90110204
138collagen fibril organization (GO:0030199)2.89834895
139positive regulation of endothelial cell apoptotic process (GO:2000353)2.89804585
140bile acid metabolic process (GO:0008206)2.89447830
141dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89124201
142convergent extension (GO:0060026)2.88835653
143regulation of triglyceride catabolic process (GO:0010896)2.87971140
144nitrogen cycle metabolic process (GO:0071941)2.87906609
145endothelial cell morphogenesis (GO:0001886)2.86633362
146tyrosine metabolic process (GO:0006570)2.86318181
147amino-acid betaine metabolic process (GO:0006577)2.86154264
148negative regulation of axon guidance (GO:1902668)2.85724503
149lung-associated mesenchyme development (GO:0060484)2.85292949
150positive regulation of cartilage development (GO:0061036)2.84947664
151substrate adhesion-dependent cell spreading (GO:0034446)2.84683851
152glomerular basement membrane development (GO:0032836)2.83248395
153cell-substrate adherens junction assembly (GO:0007045)2.83107770
154focal adhesion assembly (GO:0048041)2.83107770
155negative regulation of stem cell proliferation (GO:2000647)2.82805678
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82738116
157DNA unwinding involved in DNA replication (GO:0006268)2.82576621
158positive regulation of osteoblast proliferation (GO:0033690)2.81720778
159regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.81608101
160peptidyl-proline hydroxylation (GO:0019511)2.78314332
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77863656
162negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.77387085
163dermatan sulfate biosynthetic process (GO:0030208)2.76770678
164lung lobe morphogenesis (GO:0060463)2.76134332
165one-carbon metabolic process (GO:0006730)2.75571776
166blood vessel maturation (GO:0001955)2.75401304
167renal system development (GO:0072001)2.75366950
168cellular amino acid catabolic process (GO:0009063)2.75181430
169trabecula formation (GO:0060343)2.74400059
170smooth muscle tissue development (GO:0048745)2.74122630
171acetyl-CoA metabolic process (GO:0006084)2.73829724
172hyaluronan catabolic process (GO:0030214)2.73237085
173cell proliferation involved in kidney development (GO:0072111)2.71671084
174indolalkylamine metabolic process (GO:0006586)2.71348475
175ethanol oxidation (GO:0006069)2.70226530
176glucuronate metabolic process (GO:0019585)2.69567098
177uronic acid metabolic process (GO:0006063)2.69567098
178aspartate family amino acid catabolic process (GO:0009068)2.69483897
179chondrocyte development (GO:0002063)2.68786597
180plasma lipoprotein particle clearance (GO:0034381)2.67027725
181reverse cholesterol transport (GO:0043691)2.64229419
182fibrinolysis (GO:0042730)2.64152383
1832-oxoglutarate metabolic process (GO:0006103)2.62000357
184regulation of extracellular matrix organization (GO:1903053)2.61882032
185negative regulation of smooth muscle cell differentiation (GO:0051151)2.58532632
186negative regulation of lipid transport (GO:0032369)2.58309258
187coenzyme catabolic process (GO:0009109)2.58182701
188epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58102960
189cell migration involved in gastrulation (GO:0042074)2.57829084
190anterior/posterior axis specification, embryo (GO:0008595)2.56832624
191folic acid-containing compound biosynthetic process (GO:0009396)2.56300501
192negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55430626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.15663197
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.95000362
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37106774
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.35336861
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.99512660
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.79802076
7E2F7_22180533_ChIP-Seq_HELA_Human3.26273176
8WT1_19549856_ChIP-ChIP_CCG9911_Human3.08379735
9BRD4_25478319_ChIP-Seq_HGPS_Human3.07786672
10CLOCK_20551151_ChIP-Seq_293T_Human2.99514643
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.98119606
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.91488371
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.86639825
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.75292451
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57518517
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.55477688
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.36274356
18CJUN_26792858_Chip-Seq_BT549_Human2.22564868
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.16730599
20TP53_22127205_ChIP-Seq_IMR90_Human2.14992445
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.13811847
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10562905
23AR_21909140_ChIP-Seq_LNCAP_Human2.07716749
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07400139
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97450298
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.97289504
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94989878
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.92382443
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90008510
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88774724
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88376365
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87904024
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.87734651
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.85823270
35* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85107646
36ZNF263_19887448_ChIP-Seq_K562_Human1.82614611
37SMC1_22415368_ChIP-Seq_MEFs_Mouse1.80894761
38TP53_18474530_ChIP-ChIP_U2OS_Human1.79584091
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78513168
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77478290
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77220991
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.74179761
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72472265
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72122078
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.71502591
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.71272669
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70933354
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69913629
49* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67677052
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.67323405
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65368026
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65368026
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65317461
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64600355
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62538693
56SMC3_22415368_ChIP-Seq_MEFs_Mouse1.62178598
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59586066
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59287052
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56022085
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53646837
61TP53_23651856_ChIP-Seq_MEFs_Mouse1.53312534
62* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52951197
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51668683
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51668683
65SA1_22415368_ChIP-Seq_MEFs_Mouse1.51101366
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49120903
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46410760
68TP53_16413492_ChIP-PET_HCT116_Human1.46306893
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45523493
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43827371
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.43557998
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41852920
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38899077
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35715799
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34735704
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34465250
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34465250
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34215841
79* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32802720
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32605085
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32078655
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25428847
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24712649
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22490086
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19989116
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19772844
87RACK7_27058665_Chip-Seq_MCF-7_Human1.19734219
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17113280
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17069804
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15870357
91LXR_22292898_ChIP-Seq_THP-1_Human1.15815625
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15600824
93ATF3_27146783_Chip-Seq_COLON_Human1.14280645
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14174406
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.13793111
96* RNF2_27304074_Chip-Seq_ESCs_Mouse1.12246071
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12113492
98KDM2B_26808549_Chip-Seq_K562_Human1.11692032
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.11348817
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11028638
101* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10882937
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09653315
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09076421
104* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09026790
105* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08519867
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.07379365
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.06764034
108TET1_21490601_ChIP-Seq_MESCs_Mouse1.06382518
109MYC_22102868_ChIP-Seq_BL_Human1.05129673
110MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04833032
111* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04448089
112POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01503216
113XRN2_22483619_ChIP-Seq_HELA_Human1.00983916
114NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99657729
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99534602
116* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99308431
117NFI_21473784_ChIP-Seq_ESCs_Mouse0.98755268
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.98039558
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.97885072
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97482818
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97261461
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96592059
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.95164338
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94888378
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94614608
126* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94444997
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94148513
128TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93810995
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93483405
130ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93234765
131SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92979995
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92959873
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.92481020
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91958279
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91468640
136* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91345426
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91344969
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91343115
139PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.90561122
140MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90532403
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89998433
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89977232
143MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89167318
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87229039
145GATA6_25053715_ChIP-Seq_YYC3_Human0.84494936
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.83914769
147TBX20_22080862_ChIP-Seq_HEART_Mouse0.83914769
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83573874
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.82722892
150HNF4A_19822575_ChIP-Seq_HepG2_Human0.82628002
151CHD1_26751641_Chip-Seq_LNCaP_Human0.82582686
152EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82339043
153E2F1_18555785_ChIP-Seq_MESCs_Mouse0.80698014
154CREB1_26743006_Chip-Seq_LNCaP_Human0.80366266
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79781291
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79780202
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79487871
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79142070
159SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78699837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.54068776
2MP0003279_aneurysm4.03666731
3MP0005360_urolithiasis3.98882986
4MP0001958_emphysema3.89318319
5MP0003283_abnormal_digestive_organ3.86687771
6MP0005257_abnormal_intraocular_pressure3.81174637
7MP0009053_abnormal_anal_canal3.36331928
8MP0005623_abnormal_meninges_morphology3.28143746
9MP0005085_abnormal_gallbladder_physiolo3.25572709
10MP0005365_abnormal_bile_salt3.08469168
11MP0001542_abnormal_bone_strength3.03447422
12MP0005503_abnormal_tendon_morphology2.92793145
13MP0002282_abnormal_trachea_morphology2.73742719
14MP0003705_abnormal_hypodermis_morpholog2.65692709
15MP0006054_spinal_hemorrhage2.61773676
16MP0003806_abnormal_nucleotide_metabolis2.59732428
17MP0003950_abnormal_plasma_membrane2.58701853
18MP0010368_abnormal_lymphatic_system2.42382231
19MP0002234_abnormal_pharynx_morphology2.05416320
20MP0010030_abnormal_orbit_morphology2.04547056
21MP0008875_abnormal_xenobiotic_pharmacok2.00681751
22MP0003091_abnormal_cell_migration1.92944379
23MP0008438_abnormal_cutaneous_collagen1.92890230
24MP0003252_abnormal_bile_duct1.92264727
25MP0000566_synostosis1.87096226
26MP0001299_abnormal_eye_distance/1.86963535
27MP0000751_myopathy1.82994469
28MP0005083_abnormal_biliary_tract1.73758819
29MP0002295_abnormal_pulmonary_circulatio1.72569546
30MP0010329_abnormal_lipoprotein_level1.71849539
31MP0003123_paternal_imprinting1.71164401
32MP0002932_abnormal_joint_morphology1.66975218
33MP0000163_abnormal_cartilage_morphology1.62121106
34MP0000537_abnormal_urethra_morphology1.61964736
35MP0003942_abnormal_urinary_system1.60999245
36MP0002060_abnormal_skin_morphology1.59785058
37MP0003941_abnormal_skin_development1.59728032
38MP0003119_abnormal_digestive_system1.57377055
39MP0009250_abnormal_appendicular_skeleto1.53371819
40MP0002249_abnormal_larynx_morphology1.50261079
41MP0000013_abnormal_adipose_tissue1.49276838
42MP0001243_abnormal_dermal_layer1.44692860
43MP0001348_abnormal_lacrimal_gland1.43239366
44MP0002697_abnormal_eye_size1.41647893
45MP0000733_abnormal_muscle_development1.41334320
46MP0004272_abnormal_basement_membrane1.40545296
47MP0005332_abnormal_amino_acid1.37536111
48MP0009780_abnormal_chondrocyte_physiolo1.36609228
49MP0003937_abnormal_limbs/digits/tail_de1.35076626
50MP0004019_abnormal_vitamin_homeostasis1.33841731
51MP0000462_abnormal_digestive_system1.29621791
52MP0003115_abnormal_respiratory_system1.29575727
53MP0010386_abnormal_urinary_bladder1.25963590
54MP0005508_abnormal_skeleton_morphology1.25623222
55MP0002653_abnormal_ependyma_morphology1.23853954
56MP0004858_abnormal_nervous_system1.23372258
57MP0002115_abnormal_skeleton_extremities1.22044475
58MP0005197_abnormal_uvea_morphology1.21916674
59MP0001666_abnormal_nutrient_absorption1.21599718
60MP0005275_abnormal_skin_tensile1.20406702
61MP0002111_abnormal_tail_morphology1.20079071
62MP0005595_abnormal_vascular_smooth1.19902495
63MP0000749_muscle_degeneration1.19225164
64MP0004197_abnormal_fetal_growth/weight/1.18536750
65MP0002896_abnormal_bone_mineralization1.18397410
66MP0009840_abnormal_foam_cell1.16091609
67MP0000762_abnormal_tongue_morphology1.13887046
68MP0001881_abnormal_mammary_gland1.12309234
69MP0000579_abnormal_nail_morphology1.11769340
70MP0005248_abnormal_Harderian_gland1.11503607
71MP0000534_abnormal_ureter_morphology1.11055544
72MP0002254_reproductive_system_inflammat1.10839632
73MP0002098_abnormal_vibrissa_morphology1.08893338
74MP0005076_abnormal_cell_differentiation1.08359612
75MP0002877_abnormal_melanocyte_morpholog1.07337807
76MP0003385_abnormal_body_wall1.05824883
77MP0000609_abnormal_liver_physiology1.05778755
78MP0010352_gastrointestinal_tract_polyps1.05225489
79MP0005666_abnormal_adipose_tissue1.05224609
80MP0005670_abnormal_white_adipose1.05027961
81MP0003890_abnormal_embryonic-extraembry1.04438166
82MP0000759_abnormal_skeletal_muscle1.01976437
83MP0001849_ear_inflammation1.01224001
84MP0002233_abnormal_nose_morphology1.00869404
85MP0002092_abnormal_eye_morphology1.00765007
86MP0000428_abnormal_craniofacial_morphol1.00300968
87MP0005023_abnormal_wound_healing0.99790844
88MP0002933_joint_inflammation0.99651354
89MP0002116_abnormal_craniofacial_bone0.98794191
90MP0002113_abnormal_skeleton_development0.98552144
91MP0003195_calcinosis0.97988121
92MP0005319_abnormal_enzyme/_coenzyme0.97933582
93MP0002108_abnormal_muscle_morphology0.97878888
94MP0005390_skeleton_phenotype0.95777806
95MP0000049_abnormal_middle_ear0.95250283
96MP0010234_abnormal_vibrissa_follicle0.93866958
97MP0001286_abnormal_eye_development0.93445479
98MP0002109_abnormal_limb_morphology0.93165673
99MP0003935_abnormal_craniofacial_develop0.92781278
100MP0003011_delayed_dark_adaptation0.92382085
101MP0000750_abnormal_muscle_regeneration0.91270829
102MP0005193_abnormal_anterior_eye0.90608976
103MP0001293_anophthalmia0.90061065
104MP0009384_cardiac_valve_regurgitation0.89837647
105MP0004185_abnormal_adipocyte_glucose0.89213198
106MP0003566_abnormal_cell_adhesion0.88126376
107MP0000383_abnormal_hair_follicle0.88080463
108MP0010678_abnormal_skin_adnexa0.86467569
109MP0002084_abnormal_developmental_patter0.86345375
110MP0000767_abnormal_smooth_muscle0.84124250
111MP0002089_abnormal_postnatal_growth/wei0.82333414
112MP0002118_abnormal_lipid_homeostasis0.81856089
113MP0002128_abnormal_blood_circulation0.81721320
114MP0000003_abnormal_adipose_tissue0.81502809
115MP0001879_abnormal_lymphatic_vessel0.81350326
116MP0004264_abnormal_extraembryonic_tissu0.81085356
117MP0001672_abnormal_embryogenesis/_devel0.80563459
118MP0005380_embryogenesis_phenotype0.80563459
119MP0003755_abnormal_palate_morphology0.80469844
120MP0002088_abnormal_embryonic_growth/wei0.79620689
121MP0000432_abnormal_head_morphology0.79536884
122MP0004134_abnormal_chest_morphology0.78522006
123MP0003448_altered_tumor_morphology0.78457002
124MP0003984_embryonic_growth_retardation0.78414867
125MP0002177_abnormal_outer_ear0.78072431
126MP0000467_abnormal_esophagus_morphology0.77898904
127MP0008961_abnormal_basal_metabolism0.76023325
128MP0002085_abnormal_embryonic_tissue0.74486596
129MP0002102_abnormal_ear_morphology0.74481883
130MP0002114_abnormal_axial_skeleton0.73771499
131MP0004133_heterotaxia0.72883956
132MP0009697_abnormal_copulation0.72506657
133MP0001270_distended_abdomen0.72184908
134MP0003646_muscle_fatigue0.72156042
135MP0001730_embryonic_growth_arrest0.69910471
136MP0001614_abnormal_blood_vessel0.69167156
137MP0001915_intracranial_hemorrhage0.68927277
138MP0001175_abnormal_lung_morphology0.65329676
139MP0002168_other_aberrant_phenotype0.64356222
140MP0005164_abnormal_response_to0.58627476
141MP0000538_abnormal_urinary_bladder0.58037922
142MP0002925_abnormal_cardiovascular_devel0.55922255
143MP0008789_abnormal_olfactory_epithelium0.53123718
144MP0003795_abnormal_bone_structure0.52315306
145MP0005171_absent_coat_pigmentation0.52041144
146MP0002133_abnormal_respiratory_system0.51906291
147MP0005388_respiratory_system_phenotype0.51906291
148MP0000858_altered_metastatic_potential0.48675942
149MP0005620_abnormal_muscle_contractility0.48460299
150MP0004087_abnormal_muscle_fiber0.47396324
151MP0001340_abnormal_eyelid_morphology0.45432209
152MP0004233_abnormal_muscle_weight0.45257935

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)5.36583069
2Aortic dissection (HP:0002647)4.91603072
3Epiphyseal dysplasia (HP:0002656)4.89128841
4Aortic aneurysm (HP:0004942)4.62916824
5Type 1 muscle fiber predominance (HP:0003803)4.41078948
6Follicular hyperkeratosis (HP:0007502)4.40310665
7Irregular epiphyses (HP:0010582)4.39683699
8Vitreoretinal degeneration (HP:0000655)4.37223794
9Vascular tortuosity (HP:0004948)4.36893307
10Soft skin (HP:0000977)4.24133581
11Deep venous thrombosis (HP:0002625)4.23294889
12Abnormality of dentin (HP:0010299)4.13450045
13Bladder diverticulum (HP:0000015)4.07868280
14Spinal rigidity (HP:0003306)4.06697446
15Atrophic scars (HP:0001075)4.05899951
16Metaphyseal cupping (HP:0003021)4.02641218
17Abnormal tarsal ossification (HP:0008369)3.88993871
18Arterial tortuosity (HP:0005116)3.77763103
19Slender build (HP:0001533)3.71678743
20Broad metatarsal (HP:0001783)3.61522591
21Genu recurvatum (HP:0002816)3.60556528
22Cupped ribs (HP:0000887)3.59246681
23Fragile skin (HP:0001030)3.56088737
24Small epiphyses (HP:0010585)3.52382021
25Wormian bones (HP:0002645)3.42133054
26Abnormality of monocarboxylic acid metabolism (HP:0010996)3.36105708
27Intrahepatic cholestasis (HP:0001406)3.35637479
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32129007
29Exostoses (HP:0100777)3.31738333
30Hypoplastic ischia (HP:0003175)3.26685307
31Vertebral compression fractures (HP:0002953)3.24249544
32Flat acetabular roof (HP:0003180)3.23210112
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.16307206
34Delayed epiphyseal ossification (HP:0002663)3.13131811
35Hypobetalipoproteinemia (HP:0003563)3.11531953
36Xanthomatosis (HP:0000991)3.07984051
37Osteoarthritis (HP:0002758)3.05993227
38Peritonitis (HP:0002586)3.04371648
39Dilatation of the ascending aorta (HP:0005111)3.02737095
40Bowel diverticulosis (HP:0005222)2.99518765
41Protrusio acetabuli (HP:0003179)2.98275682
42Abnormality of the ischium (HP:0003174)2.94003773
43Mildly elevated creatine phosphokinase (HP:0008180)2.92910097
44Spondylolisthesis (HP:0003302)2.88794453
45Increased variability in muscle fiber diameter (HP:0003557)2.86246878
46Hepatoblastoma (HP:0002884)2.82305002
47Abnormal foot bone ossification (HP:0010675)2.77776057
48Mitral regurgitation (HP:0001653)2.76983650
49Neonatal short-limb short stature (HP:0008921)2.76624150
50Elbow flexion contracture (HP:0002987)2.75271648
51Biconcave vertebral bodies (HP:0004586)2.74441879
52Hypoventilation (HP:0002791)2.73486938
53Joint laxity (HP:0001388)2.71268851
54Mitral valve prolapse (HP:0001634)2.69887234
55Hyperextensible skin (HP:0000974)2.66078185
56Aortic regurgitation (HP:0001659)2.62856257
57Limited elbow extension (HP:0001377)2.62526358
58Genu varum (HP:0002970)2.60298465
59Flat capital femoral epiphysis (HP:0003370)2.56793459
60Mesomelia (HP:0003027)2.55850816
61Coronal craniosynostosis (HP:0004440)2.54490867
62Concave nail (HP:0001598)2.51332508
63Wrist flexion contracture (HP:0001239)2.47114350
64Round ear (HP:0100830)2.43683703
65Hypolipoproteinemia (HP:0010981)2.42664036
66Abnormal cartilage morphology (HP:0002763)2.41606875
67Abnormality of the acetabulum (HP:0003170)2.39707673
68Generalized amyotrophy (HP:0003700)2.39373313
69Disproportionate tall stature (HP:0001519)2.39015959
70Abnormality of skeletal muscle fiber size (HP:0012084)2.38797300
71Camptodactyly of toe (HP:0001836)2.36571150
72Short nail (HP:0001799)2.33112094
73Abnormal delivery (HP:0001787)2.32245925
74Glomerulonephritis (HP:0000099)2.30951803
75Overgrowth (HP:0001548)2.30345515
76Abnormality of carpal bone ossification (HP:0006257)2.28246139
77Lymphangioma (HP:0100764)2.27701523
78Joint stiffness (HP:0001387)2.26587920
79Prolonged partial thromboplastin time (HP:0003645)2.25988137
80Hypoalphalipoproteinemia (HP:0003233)2.25399853
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.25219322
82Achilles tendon contracture (HP:0001771)2.25206289
83Protuberant abdomen (HP:0001538)2.22455072
84Osteolytic defects of the hand bones (HP:0009699)2.22074454
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.22074454
86Abnormal vertebral ossification (HP:0100569)2.21907584
87Natal tooth (HP:0000695)2.21334071
88Aortic valve stenosis (HP:0001650)2.20882276
89Long toe (HP:0010511)2.20797568
90Platyspondyly (HP:0000926)2.20734829
91Increased connective tissue (HP:0009025)2.19253453
92Back pain (HP:0003418)2.18247071
93Complement deficiency (HP:0004431)2.18226990
94Ketosis (HP:0001946)2.15967879
95Hyperlipoproteinemia (HP:0010980)2.15897635
96Distal upper limb amyotrophy (HP:0007149)2.14346843
97Upper limb amyotrophy (HP:0009129)2.14346843
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13373835
99Hyperammonemia (HP:0001987)2.13202104
100Mild short stature (HP:0003502)2.12953174
101Limb-girdle muscle weakness (HP:0003325)2.11433064
102Abnormality of the common coagulation pathway (HP:0010990)2.11334263
103Deviation of the hallux (HP:0010051)2.10638665
104Blue sclerae (HP:0000592)2.10212201
105Abnormality of the vertebral endplates (HP:0005106)2.09409380
106Hallux valgus (HP:0001822)2.09058886
107Arthropathy (HP:0003040)2.08669340
108Abnormal ossification of hand bones (HP:0005921)2.08629994
109Breech presentation (HP:0001623)2.08021003
110Irregular vertebral endplates (HP:0003301)2.05679385
111Renal duplication (HP:0000075)2.04718140
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04257079
113Absent phalangeal crease (HP:0006109)2.03557194
114Short 5th finger (HP:0009237)2.03368101
115Carpal bone hypoplasia (HP:0001498)2.02900887
116Aplasia of the musculature (HP:0100854)2.02710860
117Lumbar hyperlordosis (HP:0002938)2.01975975
118Ulnar bowing (HP:0003031)2.01895413
119Metaphyseal dysplasia (HP:0100255)2.00599434
120Abnormality of methionine metabolism (HP:0010901)2.00275486
121Aneurysm (HP:0002617)2.00081641
122Mitral stenosis (HP:0001718)1.99864319
123Broad thumb (HP:0011304)1.99329025
124Entropion (HP:0000621)1.99019598
125Vertebral clefting (HP:0008428)1.98770238
126Spastic diplegia (HP:0001264)1.97479156
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95830906
128Thin ribs (HP:0000883)1.95706442
129Epidermoid cyst (HP:0200040)1.95702786
130Absent epiphyses (HP:0010577)1.95245311
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95245311
132Coxa vara (HP:0002812)1.94955104
133Abnormality of the intrinsic pathway (HP:0010989)1.94234637
134Rhizomelia (HP:0008905)1.94148914
135Delayed cranial suture closure (HP:0000270)1.93612468
136Absent frontal sinuses (HP:0002688)1.93507831
137Cerebral aneurysm (HP:0004944)1.93391147
138Congenital glaucoma (HP:0001087)1.93173735
139Premature rupture of membranes (HP:0001788)1.93123810
140Abnormality of the Achilles tendon (HP:0005109)1.91274835
141Protruding ear (HP:0000411)1.90461489
142Right ventricular cardiomyopathy (HP:0011663)1.89611065
143Thoracolumbar scoliosis (HP:0002944)1.89603511
144Hyperglycinuria (HP:0003108)1.88360149
145Nephritis (HP:0000123)1.88313860
146Flat cornea (HP:0007720)1.88202635
147Abnormal hand bone ossification (HP:0010660)1.87700755
148Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87464319
149Hepatocellular carcinoma (HP:0001402)1.87111902
150Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.86860609
151Abnormality of femoral epiphyses (HP:0006499)1.86860609
152Sprengel anomaly (HP:0000912)1.86720203
153Wide anterior fontanel (HP:0000260)1.85938732
154Bowed forearm bones (HP:0003956)1.85424791
155Bowing of the arm (HP:0006488)1.85424791
156Nonimmune hydrops fetalis (HP:0001790)1.84573368
157Inguinal hernia (HP:0000023)1.83598977
158Abnormality of skull ossification (HP:0002703)1.83524757
159Ectopia lentis (HP:0001083)1.83400948
160Joint contractures involving the joints of the feet (HP:0100492)1.83297345
161Flexion contracture of toe (HP:0005830)1.83297345
162Spinal cord compression (HP:0002176)1.82648125
163Diastasis recti (HP:0001540)1.82275564
164Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.82220004
165Broad phalanx (HP:0006009)1.82170764
166Abnormality of the proximal phalanges of the hand (HP:0009834)1.81839227
167Abnormality of the pubic bones (HP:0003172)1.81731947
168Hyperglycinemia (HP:0002154)1.80276509
169Shallow orbits (HP:0000586)1.78071192
170Broad long bones (HP:0005622)1.77464883
171Cardiovascular calcification (HP:0011915)1.76882418
172Infantile muscular hypotonia (HP:0008947)1.76485504
173Ovoid vertebral bodies (HP:0003300)1.76368951
174Cervical subluxation (HP:0003308)1.76212686
175Redundant skin (HP:0001582)1.76211047
176Vascular calcification (HP:0004934)1.75755508
177Bilateral microphthalmos (HP:0007633)1.75720552
178Deformed tarsal bones (HP:0008119)1.74796357
179Abnormal number of incisors (HP:0011064)1.74770057
180Reduced subcutaneous adipose tissue (HP:0003758)1.73890703
181Syringomyelia (HP:0003396)1.73684941
182Spinal cord lesions (HP:0100561)1.73684941
183Partial duplication of the phalanx of hand (HP:0009999)1.73273301
184Hydroureter (HP:0000072)1.71319361
185Hand muscle atrophy (HP:0009130)1.71119153
186Distal lower limb amyotrophy (HP:0008944)1.70684478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.94989176
2SIK14.15167853
3LIMK13.36975374
4TRIB33.35752639
5BCKDK3.12734229
6DDR22.85362242
7LATS12.74206877
8PKN22.68713685
9MAP3K102.55100344
10EPHB22.54884003
11MOS2.52599407
12STK38L2.52085418
13ERN12.43654573
14EPHA22.39885581
15NTRK12.35082127
16LATS22.35009421
17FGFR42.14612802
18MAP3K32.04215916
19PRKD21.97409892
20BUB11.90022611
21PTK61.82082379
22PDGFRA1.78439550
23NEK11.74427761
24CDC71.70027983
25FGFR21.69067584
26PAK41.63157100
27STK381.53431296
28CDK121.52332546
29FGFR11.43358046
30GRK71.42754819
31PAK61.40338087
32TTN1.38077571
33TGFBR11.37867176
34PASK1.37000072
35CDC42BPA1.36404814
36ROCK21.30498953
37KSR11.27916727
38PDK31.26189974
39PDK41.26189974
40DAPK31.18707589
41ERBB21.16927299
42PIM21.13929718
43TESK11.12894517
44DMPK1.11163838
45TRPM71.10937529
46ICK1.09895736
47PTK21.07723457
48ABL21.02648752
49EEF2K1.02476029
50STK31.02468918
51AKT31.01253927
52RPS6KA21.01052776
53ADRBK10.98550138
54FER0.98418352
55MTOR0.97720951
56ARAF0.95111731
57RIPK10.95105567
58CDK60.93949495
59DYRK1B0.92449207
60MAP3K60.92148472
61CAMK1D0.91748496
62PTK2B0.91054642
63CAMK1G0.89479284
64LRRK20.89441164
65PAK10.88771405
66KDR0.88008569
67TYRO30.87608795
68CDK70.83000553
69LMTK20.82879860
70TTK0.82024169
71GRK60.81836342
72SMG10.81322097
73DYRK30.80538671
74NEK90.79807543
75PIK3CA0.78007328
76MAP3K110.77220218
77RPS6KA40.76909978
78CDK80.76324244
79PAK30.76062511
80EIF2AK10.75815185
81PAK20.73162018
82CDK40.72449625
83BMX0.71043299
84ERBB40.70893325
85MAPK70.70117863
86STK100.69327806
87MAP3K80.68542020
88PDK20.67793263
89BCR0.66762147
90RPS6KB20.65997127
91FGFR30.65717883
92EPHB10.65483187
93IRAK30.64588614
94MET0.61810398
95TGFBR20.60708488
96FLT30.59320380
97FRK0.59319894
98PRKG20.58844439
99WEE10.58066557
100STK240.57270603
101PDGFRB0.57024189
102CDK150.55113578
103CDK11A0.54197986
104AURKB0.53551470
105WNK10.53130016
106BRAF0.51676677
107TAOK20.51297164
108CDK180.50394384
109NEK20.50017958
110PIK3CG0.49126010
111CDK140.48271428
112AKT20.48028608
113RPS6KL10.47573263
114RPS6KC10.47573263
115MAP3K70.47361012
116ROCK10.46766043
117MELK0.45628078
118IRAK20.45374716
119GSK3A0.44550032
120CAMK2G0.43674824
121AURKA0.43555823
122SIK30.43427298
123MAP2K10.43227307
124NME20.43010894
125BRSK10.42205426
126PLK20.42187251
127IRAK10.41182332
128TESK20.40578745
129PRPF4B0.40551429
130MKNK10.39404522
131MAP2K30.39252619
132ILK0.38849211
133WNK40.38246371
134MAPKAPK20.35906524
135PRKD10.35642160
136TSSK60.35303091
137CHEK10.34393356
138RET0.33639231
139PLK10.32745717
140CHEK20.32714740
141RPS6KA60.31258327
142PRKD30.31135456
143CHUK0.30475298
144STK40.29903129
145EPHA30.29720250
146CLK10.29704050
147ATR0.29417070
148GRK50.28921961
149MUSK0.27785444
150CAMK2B0.24366464

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.40780455
2Nitrogen metabolism_Homo sapiens_hsa009102.99866358
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94424634
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.91982086
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59641102
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51825390
7Arginine biosynthesis_Homo sapiens_hsa002202.48658628
8Tryptophan metabolism_Homo sapiens_hsa003802.47292493
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.40873490
10Dilated cardiomyopathy_Homo sapiens_hsa054142.35123950
11Selenocompound metabolism_Homo sapiens_hsa004502.22661420
12Fatty acid degradation_Homo sapiens_hsa000712.19864748
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.15966585
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13932860
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09924714
16Regulation of actin cytoskeleton_Homo sapiens_hsa048102.06612353
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.06163888
18Complement and coagulation cascades_Homo sapiens_hsa046102.06031344
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05409223
20Propanoate metabolism_Homo sapiens_hsa006401.93948736
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.92419809
22Amoebiasis_Homo sapiens_hsa051461.88212923
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77804355
24* Basal cell carcinoma_Homo sapiens_hsa052171.77338459
25Biosynthesis of amino acids_Homo sapiens_hsa012301.76529678
26Fatty acid metabolism_Homo sapiens_hsa012121.71335965
27One carbon pool by folate_Homo sapiens_hsa006701.70156905
28PPAR signaling pathway_Homo sapiens_hsa033201.68281539
29Melanoma_Homo sapiens_hsa052181.67920025
30Butanoate metabolism_Homo sapiens_hsa006501.66904030
31Pyruvate metabolism_Homo sapiens_hsa006201.65738490
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65080333
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60155289
34Caffeine metabolism_Homo sapiens_hsa002321.58581309
35Phenylalanine metabolism_Homo sapiens_hsa003601.54015190
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.53838803
37Chemical carcinogenesis_Homo sapiens_hsa052041.53123975
38Carbon metabolism_Homo sapiens_hsa012001.50966562
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45100522
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44798399
41Peroxisome_Homo sapiens_hsa041461.44708197
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43368486
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.43277281
44Folate biosynthesis_Homo sapiens_hsa007901.40860018
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.40434440
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39191272
47beta-Alanine metabolism_Homo sapiens_hsa004101.35776237
48Axon guidance_Homo sapiens_hsa043601.34055002
49ECM-receptor interaction_Homo sapiens_hsa045121.31265013
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29136122
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28559253
52N-Glycan biosynthesis_Homo sapiens_hsa005101.28507966
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26794549
54* Hedgehog signaling pathway_Homo sapiens_hsa043401.25533568
55Lysine degradation_Homo sapiens_hsa003101.23265763
56Retinol metabolism_Homo sapiens_hsa008301.22804539
57p53 signaling pathway_Homo sapiens_hsa041151.20522694
58Bile secretion_Homo sapiens_hsa049761.18783072
59Tyrosine metabolism_Homo sapiens_hsa003501.17727689
60* Pathways in cancer_Homo sapiens_hsa052001.16941479
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.16761194
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13361057
63Chronic myeloid leukemia_Homo sapiens_hsa052201.13248114
64Starch and sucrose metabolism_Homo sapiens_hsa005001.12638525
65Vibrio cholerae infection_Homo sapiens_hsa051101.12354299
66Sulfur metabolism_Homo sapiens_hsa009201.12312338
67Shigellosis_Homo sapiens_hsa051311.09933718
68Gap junction_Homo sapiens_hsa045401.05516138
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05057277
70Histidine metabolism_Homo sapiens_hsa003401.04198612
71* Melanogenesis_Homo sapiens_hsa049161.04153484
72* Hippo signaling pathway_Homo sapiens_hsa043901.02110312
73Protein digestion and absorption_Homo sapiens_hsa049741.00980570
74Rap1 signaling pathway_Homo sapiens_hsa040150.98889282
75Arginine and proline metabolism_Homo sapiens_hsa003300.95665952
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90737466
77Sulfur relay system_Homo sapiens_hsa041220.90170864
78Fat digestion and absorption_Homo sapiens_hsa049750.88244269
79Other glycan degradation_Homo sapiens_hsa005110.87535314
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.86196717
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85260311
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84290273
83Glioma_Homo sapiens_hsa052140.84285232
84Prostate cancer_Homo sapiens_hsa052150.82349917
85Prion diseases_Homo sapiens_hsa050200.80332445
86DNA replication_Homo sapiens_hsa030300.80202134
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.78688548
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.76972960
89Endocytosis_Homo sapiens_hsa041440.76574031
90Pancreatic cancer_Homo sapiens_hsa052120.75456873
91Glutathione metabolism_Homo sapiens_hsa004800.74646818
92Bladder cancer_Homo sapiens_hsa052190.73123699
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71681321
94Steroid biosynthesis_Homo sapiens_hsa001000.69806770
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69419772
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68655112
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.68088136
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67894756
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65920548
100Staphylococcus aureus infection_Homo sapiens_hsa051500.65058119
101Fatty acid elongation_Homo sapiens_hsa000620.64891840
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.63073145
103Malaria_Homo sapiens_hsa051440.62985639
104* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61755118
105Ras signaling pathway_Homo sapiens_hsa040140.60998155
106TGF-beta signaling pathway_Homo sapiens_hsa043500.60393487
107* Proteoglycans in cancer_Homo sapiens_hsa052050.60110475
108Pentose phosphate pathway_Homo sapiens_hsa000300.58963332
109Galactose metabolism_Homo sapiens_hsa000520.57872745
110Focal adhesion_Homo sapiens_hsa045100.57580257
111Cocaine addiction_Homo sapiens_hsa050300.57430133
112Lysosome_Homo sapiens_hsa041420.56999337
113Adherens junction_Homo sapiens_hsa045200.56648087
114Insulin resistance_Homo sapiens_hsa049310.54994314
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.54863005
116Endometrial cancer_Homo sapiens_hsa052130.54170537
117* HTLV-I infection_Homo sapiens_hsa051660.52857522
118Fatty acid biosynthesis_Homo sapiens_hsa000610.52772960
119Salmonella infection_Homo sapiens_hsa051320.52512428
120MAPK signaling pathway_Homo sapiens_hsa040100.51508953
121Colorectal cancer_Homo sapiens_hsa052100.51441586
122Apoptosis_Homo sapiens_hsa042100.50984326
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49903172
124Thyroid hormone synthesis_Homo sapiens_hsa049180.49804032
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49232174
126Small cell lung cancer_Homo sapiens_hsa052220.46136619
127AMPK signaling pathway_Homo sapiens_hsa041520.45284103
128Estrogen signaling pathway_Homo sapiens_hsa049150.44909521
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44650407
130Hepatitis B_Homo sapiens_hsa051610.42508284
131Renal cell carcinoma_Homo sapiens_hsa052110.42119365
132Cell cycle_Homo sapiens_hsa041100.41685185
133TNF signaling pathway_Homo sapiens_hsa046680.39894780
134Phagosome_Homo sapiens_hsa041450.39110371
135Glucagon signaling pathway_Homo sapiens_hsa049220.38891985
136MicroRNAs in cancer_Homo sapiens_hsa052060.38502402
137GnRH signaling pathway_Homo sapiens_hsa049120.37595113
138Thyroid cancer_Homo sapiens_hsa052160.37181345
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36838317
140Vitamin digestion and absorption_Homo sapiens_hsa049770.36727667
141Non-small cell lung cancer_Homo sapiens_hsa052230.35906847
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34914633
143Notch signaling pathway_Homo sapiens_hsa043300.34445204
144Platelet activation_Homo sapiens_hsa046110.33579918
145Spliceosome_Homo sapiens_hsa030400.32792014
146Nucleotide excision repair_Homo sapiens_hsa034200.30933524
147RNA transport_Homo sapiens_hsa030130.30219633
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30149380
149Metabolic pathways_Homo sapiens_hsa011000.30051324
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28966924
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26921459
152Oxytocin signaling pathway_Homo sapiens_hsa049210.26787589
153VEGF signaling pathway_Homo sapiens_hsa043700.26474038
154cAMP signaling pathway_Homo sapiens_hsa040240.26032472
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25428156
156Sphingolipid metabolism_Homo sapiens_hsa006000.25379177
157Cholinergic synapse_Homo sapiens_hsa047250.25234106
158Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24749309
159Fructose and mannose metabolism_Homo sapiens_hsa000510.24690975
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.24140414
161Tight junction_Homo sapiens_hsa045300.24111629
162ErbB signaling pathway_Homo sapiens_hsa040120.24048202
163Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22376817
164* Wnt signaling pathway_Homo sapiens_hsa043100.21231824
165Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21017973
166Base excision repair_Homo sapiens_hsa034100.20772661
167Glycerolipid metabolism_Homo sapiens_hsa005610.19295722
168Mismatch repair_Homo sapiens_hsa034300.19087279

Most similar genes based on co-expression Upload to Enrichr

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