WNT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung morphogenesis (GO:0060425)8.62062427
2cell migration involved in gastrulation (GO:0042074)7.62761375
3nodal signaling pathway (GO:0038092)7.51823965
4negative regulation of metanephros development (GO:0072217)7.38781878
5desmosome organization (GO:0002934)6.85216367
6embryonic process involved in female pregnancy (GO:0060136)6.53695323
7positive regulation of SMAD protein import into nucleus (GO:0060391)6.52742451
8maternal placenta development (GO:0001893)6.38224878
9ribosomal small subunit biogenesis (GO:0042274)6.31157397
10regulation of odontogenesis of dentin-containing tooth (GO:0042487)6.23987590
11response to parathyroid hormone (GO:0071107)6.19037331
12epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.97219410
13morphogenesis of embryonic epithelium (GO:0016331)5.78246776
14regulation of SMAD protein import into nucleus (GO:0060390)5.77356292
15branching involved in salivary gland morphogenesis (GO:0060445)5.69783545
16negative regulation of kidney development (GO:0090185)5.48426649
17maturation of SSU-rRNA (GO:0030490)5.20312656
18hepatocyte apoptotic process (GO:0097284)5.17734863
19morphogenesis of an epithelial fold (GO:0060571)5.09316616
20SMAD protein signal transduction (GO:0060395)4.90360371
21cellular response to gonadotropin stimulus (GO:0071371)4.88881100
22bundle of His cell to Purkinje myocyte communication (GO:0086069)4.86698659
23hemidesmosome assembly (GO:0031581)4.79122736
24cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.77637582
25anatomical structure regression (GO:0060033)4.70452355
26signal transduction involved in regulation of gene expression (GO:0023019)4.66595658
27mesenchymal to epithelial transition (GO:0060231)4.64866488
28negative regulation of androgen receptor signaling pathway (GO:0060766)4.60909524
29labyrinthine layer development (GO:0060711)4.60256356
30regulation of mesoderm development (GO:2000380)4.58792472
31regulation of cell proliferation involved in kidney development (GO:1901722)4.55991543
32planar cell polarity pathway involved in neural tube closure (GO:0090179)4.54747320
33regulation of gene silencing by RNA (GO:0060966)4.52842342
34regulation of posttranscriptional gene silencing (GO:0060147)4.52842342
35regulation of gene silencing by miRNA (GO:0060964)4.52842342
36mesonephros development (GO:0001823)4.50346516
37regulation of stem cell maintenance (GO:2000036)4.50049795
38regulation of gonadotropin secretion (GO:0032276)4.48144634
39sex determination (GO:0007530)4.46597437
40negative regulation of macrophage differentiation (GO:0045650)4.44671753
41translational termination (GO:0006415)4.37083433
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.30105620
43notochord development (GO:0030903)4.27344790
44polarized epithelial cell differentiation (GO:0030859)4.20767313
45positive regulation of male gonad development (GO:2000020)4.16663771
46outflow tract septum morphogenesis (GO:0003148)4.13524922
47digestive tract morphogenesis (GO:0048546)4.10243073
48otic vesicle formation (GO:0030916)4.05589541
49regulation of hippo signaling (GO:0035330)4.00010982
50regulation of male gonad development (GO:2000018)3.99228389
51cell-cell junction maintenance (GO:0045217)3.98474859
52paraxial mesoderm development (GO:0048339)3.95596113
53metanephric mesenchyme development (GO:0072075)3.91709427
54eyelid development in camera-type eye (GO:0061029)3.85577321
55response to water (GO:0009415)3.81156526
56endodermal cell differentiation (GO:0035987)3.80875180
57type B pancreatic cell proliferation (GO:0044342)3.79647738
58muscle cell fate commitment (GO:0042693)3.79524074
59response to gonadotropin (GO:0034698)3.78766256
60male genitalia development (GO:0030539)3.78109263
61GDP-mannose metabolic process (GO:0019673)3.77033136
62regulation of mesenchymal cell apoptotic process (GO:2001053)3.75521686
63activin receptor signaling pathway (GO:0032924)3.72398389
64translational elongation (GO:0006414)3.68666460
65cardiac right ventricle morphogenesis (GO:0003215)3.65803620
66kidney mesenchyme development (GO:0072074)3.64873676
67establishment of apical/basal cell polarity (GO:0035089)3.64604808
68adrenal gland development (GO:0030325)3.64488172
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62835302
70sex differentiation (GO:0007548)3.60366702
71regulation of female gonad development (GO:2000194)3.59149990
72protein autoprocessing (GO:0016540)3.58722654
73regulation of glomerulus development (GO:0090192)3.58033594
74cell junction maintenance (GO:0034331)3.56393083
75establishment of tissue polarity (GO:0007164)3.55619925
76establishment of planar polarity (GO:0001736)3.55619925
77protein targeting to ER (GO:0045047)3.55199270
78anterior/posterior axis specification, embryo (GO:0008595)3.52677220
79regulation of gastrulation (GO:0010470)3.51727851
80cotranslational protein targeting to membrane (GO:0006613)3.51466460
81response to follicle-stimulating hormone (GO:0032354)3.50743287
82regulation of development, heterochronic (GO:0040034)3.49392751
83regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.49392603
84endocardial cushion development (GO:0003197)3.47148257
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47018687
86epithelial cell fate commitment (GO:0072148)3.43406332
87protein localization to endoplasmic reticulum (GO:0070972)3.43018386
88hemoglobin metabolic process (GO:0020027)3.41969636
89viral life cycle (GO:0019058)3.38931942
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35794944
91* regulation of odontogenesis (GO:0042481)3.35759302
92regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.32874123
93cellular protein complex disassembly (GO:0043624)3.31648261
94lung-associated mesenchyme development (GO:0060484)3.30600609
95cell proliferation in forebrain (GO:0021846)3.29930766
96male sex determination (GO:0030238)3.23023582
97organ induction (GO:0001759)3.22902193
98ribosomal large subunit biogenesis (GO:0042273)3.22518378
99oxidative phosphorylation (GO:0006119)3.21980025
100regulation of metanephros development (GO:0072215)3.20629470
101aorta morphogenesis (GO:0035909)3.20618991
102cell differentiation involved in embryonic placenta development (GO:0060706)3.19082607
103positive regulation of hair follicle development (GO:0051798)3.18798310
104positive regulation of hair cycle (GO:0042635)3.18798310
105regulation of timing of cell differentiation (GO:0048505)3.18736420
106tongue development (GO:0043586)3.16671516
107negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.16257226
108positive regulation of pseudopodium assembly (GO:0031274)3.15776868
109regulation of activin receptor signaling pathway (GO:0032925)3.15749125
110skeletal muscle organ development (GO:0060538)3.15746024
111tooth mineralization (GO:0034505)3.15659717
112folic acid metabolic process (GO:0046655)3.13537054
113embryonic skeletal joint morphogenesis (GO:0060272)3.12593776
114formation of translation preinitiation complex (GO:0001731)3.11516623
115basement membrane organization (GO:0071711)3.11311481
116regulation of water loss via skin (GO:0033561)3.10139089
117regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.09936597
118ribonucleoprotein complex biogenesis (GO:0022613)3.08428384
119embryonic hindlimb morphogenesis (GO:0035116)3.06429878
120non-canonical Wnt signaling pathway (GO:0035567)3.06191472
121galactose catabolic process (GO:0019388)3.04466986
122establishment of monopolar cell polarity (GO:0061162)3.04067932
123establishment or maintenance of monopolar cell polarity (GO:0061339)3.04067932
124negative regulation of DNA-templated transcription, elongation (GO:0032785)3.02382937
125translational initiation (GO:0006413)3.00639748
126respiratory system process (GO:0003016)3.00359289
127ribosomal small subunit assembly (GO:0000028)2.97826888
128heart valve morphogenesis (GO:0003179)2.97294124
129hippo signaling (GO:0035329)2.95682563
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.95102032
131protein complex disassembly (GO:0043241)2.94522095
132melanin biosynthetic process (GO:0042438)2.94495465
133pre-miRNA processing (GO:0031054)2.94167986
134post-anal tail morphogenesis (GO:0036342)2.92824801
135atrioventricular valve morphogenesis (GO:0003181)2.92759312
136regulation of chromatin binding (GO:0035561)2.90542393
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.90485802
138lymph vessel development (GO:0001945)2.90074959
139forebrain morphogenesis (GO:0048853)2.89032481
140regulation of androgen receptor signaling pathway (GO:0060765)2.88576477
141regulation of cardioblast differentiation (GO:0051890)2.88371157
142cell-substrate junction assembly (GO:0007044)2.87818923
143regulation of establishment of planar polarity (GO:0090175)2.87043836
144epithelial cell-cell adhesion (GO:0090136)2.86222102
145reproductive system development (GO:0061458)2.84703928
146melanin metabolic process (GO:0006582)2.83953802
147dorsal/ventral axis specification (GO:0009950)2.83361445
148wound healing, spreading of epidermal cells (GO:0035313)2.82214487
149mesenchyme development (GO:0060485)2.81034104
150glomerulus development (GO:0032835)2.79544896
151negative regulation of cell fate specification (GO:0009996)2.78727974
152trophectodermal cell differentiation (GO:0001829)2.78454733
153regulation of mitochondrial translation (GO:0070129)2.77273830
154skin development (GO:0043588)2.76529927
155positive regulation of Cdc42 GTPase activity (GO:0043089)2.76506479
156viral transcription (GO:0019083)2.75673557
157embryonic foregut morphogenesis (GO:0048617)2.75386171
158respiratory tube development (GO:0030323)2.74700241
159glomerular basement membrane development (GO:0032836)2.73198817
160genitalia development (GO:0048806)2.72180942
161bone morphogenesis (GO:0060349)2.72069671
162spliceosomal tri-snRNP complex assembly (GO:0000244)2.69969494
163osteoblast development (GO:0002076)2.69424321
164hindlimb morphogenesis (GO:0035137)2.69135377
165cardiac muscle hypertrophy in response to stress (GO:0014898)2.69011083
166muscle hypertrophy in response to stress (GO:0003299)2.69011083
167cardiac muscle adaptation (GO:0014887)2.69011083
168placenta development (GO:0001890)2.67743869
169primitive streak formation (GO:0090009)2.67440617
170protein targeting to membrane (GO:0006612)2.66604164
171macromolecular complex disassembly (GO:0032984)2.66493457
172positive regulation vascular endothelial growth factor production (GO:0010575)2.66450676
173regulation of pseudopodium assembly (GO:0031272)2.66397493
174cardiac epithelial to mesenchymal transition (GO:0060317)2.66352032
175embryonic placenta development (GO:0001892)2.66292764
176establishment of skin barrier (GO:0061436)2.65632738
177atrial septum morphogenesis (GO:0060413)2.63939002
178regulation of hair follicle development (GO:0051797)2.62847250
179diaphragm development (GO:0060539)2.61016680
180embryonic cranial skeleton morphogenesis (GO:0048701)2.60409563
181gonadal mesoderm development (GO:0007506)11.4521320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.67997564
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.79941397
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.78080968
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.58975260
5E2F7_22180533_ChIP-Seq_HELA_Human2.48314739
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.36095113
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31035211
8KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.30178164
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28186293
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.24253561
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23880651
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17058425
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14892691
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12392095
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07522445
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07522445
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07522445
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.03382314
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02543909
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98517559
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94589624
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94258349
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.93697206
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82254976
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82178953
26RACK7_27058665_Chip-Seq_MCF-7_Human1.81372810
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.78529329
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.78434611
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.77980750
30MYC_22102868_ChIP-Seq_BL_Human1.76843333
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76797004
32* P68_20966046_ChIP-Seq_HELA_Human1.75536443
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73240660
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71350887
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.70654455
36* LXR_22292898_ChIP-Seq_THP-1_Human1.67691455
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65177082
38ATF3_27146783_Chip-Seq_COLON_Human1.64934681
39SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.63436460
40* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63203457
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61020355
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60035114
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58268596
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56882510
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.54372697
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51644899
47KDM2B_26808549_Chip-Seq_DND41_Human1.50704940
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48317177
49TP53_22127205_ChIP-Seq_IMR90_Human1.47138146
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46924595
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46277731
52ZNF263_19887448_ChIP-Seq_K562_Human1.46137654
53XRN2_22483619_ChIP-Seq_HELA_Human1.45649840
54* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43113288
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40519719
56VDR_21846776_ChIP-Seq_THP-1_Human1.39141283
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38926324
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38911375
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38866613
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38428713
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37310546
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36748830
63OCT4_18692474_ChIP-Seq_MEFs_Mouse1.36202742
64DCP1A_22483619_ChIP-Seq_HELA_Human1.35797433
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35739240
66* TCF7_22412390_ChIP-Seq_EML_Mouse1.34084200
67SMC4_20622854_ChIP-Seq_HELA_Human1.33641930
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33324099
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33253065
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32927766
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32859414
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31825292
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31173949
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29994650
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29737182
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29647809
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29044543
78BCOR_27268052_Chip-Seq_Bcells_Human1.28484422
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28018590
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27509792
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.25572528
82POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25136042
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.24724541
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23171503
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22849458
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.22643849
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.21019206
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.20522064
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20425641
90KDM2B_26808549_Chip-Seq_K562_Human1.20373992
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20332920
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20220582
93* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19318271
94AR_21909140_ChIP-Seq_LNCAP_Human1.18921982
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18441550
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17600836
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16584664
98TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16491241
99CTCF_27219007_Chip-Seq_Bcells_Human1.15886328
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14916303
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14658277
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.13824898
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13547630
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12535198
105CREB1_26743006_Chip-Seq_LNCaP_Human1.12313675
106CTCF_21964334_Chip-Seq_Bcells_Human1.10745602
107ETS1_21867929_ChIP-Seq_TH2_Mouse1.10102098
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09814497
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.09609387
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09545220
111NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09128761
112* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08970590
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08164232
114VDR_24763502_ChIP-Seq_THP-1_Human1.07753484
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07442956
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07333007
117* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06230544
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06183290
119* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06153045
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.05591498
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05182515
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03883222
123BCL6_27268052_Chip-Seq_Bcells_Human1.03288277
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03130209
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02494266
126KDM5A_27292631_Chip-Seq_BREAST_Human1.01575798
127CLOCK_20551151_ChIP-Seq_293T_Human1.01279503
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01106641
129E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00902143
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99877064
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.99813598
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99659865
133* TP63_22573176_ChIP-Seq_HFKS_Human0.99542035
134ELF1_20517297_ChIP-Seq_JURKAT_Human0.98600726
135TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97914496
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97340511
137* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96520432
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96479852
139NCOR1_26117541_ChIP-Seq_K562_Human0.95146427
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.94818361
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94553573
142GATA6_25053715_ChIP-Seq_YYC3_Human0.94422070
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94265855
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93349038
145* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93241222
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92389101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009053_abnormal_anal_canal3.43362024
2MP0004133_heterotaxia3.16289874
3MP0000537_abnormal_urethra_morphology2.98635261
4MP0010234_abnormal_vibrissa_follicle2.97986177
5MP0005377_hearing/vestibular/ear_phenot2.88830103
6MP0003878_abnormal_ear_physiology2.88830103
7MP0003705_abnormal_hypodermis_morpholog2.87957906
8MP0004272_abnormal_basement_membrane2.67634466
9MP0003119_abnormal_digestive_system2.63675147
10MP0010030_abnormal_orbit_morphology2.58145513
11MP0000566_synostosis2.52008932
12MP0000428_abnormal_craniofacial_morphol2.44570843
13MP0003315_abnormal_perineum_morphology2.44262076
14MP0000678_abnormal_parathyroid_gland2.34141964
15MP0002796_impaired_skin_barrier2.24050529
16MP0003566_abnormal_cell_adhesion2.13324264
17MP0001346_abnormal_lacrimal_gland2.10759437
18MP0000462_abnormal_digestive_system2.07623743
19MP0009333_abnormal_splenocyte_physiolog2.06588961
20MP0001661_extended_life_span2.03634344
21MP0000762_abnormal_tongue_morphology2.02254466
22MP0000639_abnormal_adrenal_gland2.02138429
23MP0002234_abnormal_pharynx_morphology2.00823079
24MP0005076_abnormal_cell_differentiation1.98082747
25MP0002160_abnormal_reproductive_system1.95955684
26MP0005451_abnormal_body_composition1.95877684
27MP0005058_abnormal_lysosome_morphology1.94355532
28MP0005367_renal/urinary_system_phenotyp1.92141693
29MP0000516_abnormal_urinary_system1.92141693
30MP0008260_abnormal_autophagy1.91512853
31MP0002098_abnormal_vibrissa_morphology1.90759129
32MP0003828_pulmonary_edema1.88327030
33MP0004957_abnormal_blastocyst_morpholog1.84880011
34MP0008995_early_reproductive_senescence1.84780544
35MP0003941_abnormal_skin_development1.74957085
36MP0003111_abnormal_nucleus_morphology1.73926638
37MP0003693_abnormal_embryo_hatching1.73816490
38MP0005623_abnormal_meninges_morphology1.72398679
39MP0003942_abnormal_urinary_system1.71222771
40MP0004197_abnormal_fetal_growth/weight/1.70798353
41MP0010352_gastrointestinal_tract_polyps1.68097306
42MP0001730_embryonic_growth_arrest1.63727922
43MP0001348_abnormal_lacrimal_gland1.62681595
44MP0009672_abnormal_birth_weight1.61198489
45MP0003385_abnormal_body_wall1.59220437
46MP0005501_abnormal_skin_physiology1.58490957
47MP0002111_abnormal_tail_morphology1.56684434
48MP0003077_abnormal_cell_cycle1.56234643
49MP0002249_abnormal_larynx_morphology1.55709677
50MP0003115_abnormal_respiratory_system1.55683317
51MP0008932_abnormal_embryonic_tissue1.55443898
52MP0001849_ear_inflammation1.55212897
53MP0008438_abnormal_cutaneous_collagen1.52894076
54MP0001697_abnormal_embryo_size1.51989594
55MP0002084_abnormal_developmental_patter1.50806922
56MP0005275_abnormal_skin_tensile1.49222135
57MP0000383_abnormal_hair_follicle1.48205346
58MP0000049_abnormal_middle_ear1.46491023
59MP0003937_abnormal_limbs/digits/tail_de1.45000815
60MP0006138_congestive_heart_failure1.43895443
61MP0002254_reproductive_system_inflammat1.41670723
62MP0002085_abnormal_embryonic_tissue1.35215372
63MP0005646_abnormal_pituitary_gland1.34981668
64MP0003123_paternal_imprinting1.32758977
65MP0002086_abnormal_extraembryonic_tissu1.31443642
66MP0003935_abnormal_craniofacial_develop1.30756501
67MP0004185_abnormal_adipocyte_glucose1.29953549
68MP0000350_abnormal_cell_proliferation1.29642139
69MP0004264_abnormal_extraembryonic_tissu1.28304820
70MP0008007_abnormal_cellular_replicative1.27958315
71MP0001340_abnormal_eyelid_morphology1.24530325
72MP0003091_abnormal_cell_migration1.22973414
73MP0001958_emphysema1.16313217
74MP0002653_abnormal_ependyma_morphology1.14805115
75MP0005380_embryogenesis_phenotype1.14073562
76MP0001672_abnormal_embryogenesis/_devel1.14073562
77MP0000733_abnormal_muscle_development1.13058941
78MP0004858_abnormal_nervous_system1.12459812
79MP0003786_premature_aging1.11756130
80MP0001216_abnormal_epidermal_layer1.10739428
81MP0000467_abnormal_esophagus_morphology1.10529788
82MP0000432_abnormal_head_morphology1.06580902
83MP0005389_reproductive_system_phenotype1.05908844
84MP0005023_abnormal_wound_healing1.04662993
85MP0000470_abnormal_stomach_morphology1.04028473
86MP0002127_abnormal_cardiovascular_syste1.02371891
87MP0009384_cardiac_valve_regurgitation1.00238545
88MP0003866_abnormal_defecation1.00097427
89MP0005670_abnormal_white_adipose0.99418906
90MP0003755_abnormal_palate_morphology0.99039182
91MP0000534_abnormal_ureter_morphology0.97422191
92MP0002080_prenatal_lethality0.97153985
93MP0004782_abnormal_surfactant_physiolog0.96887743
94MP0000767_abnormal_smooth_muscle0.95338198
95MP0010678_abnormal_skin_adnexa0.95140593
96MP0002233_abnormal_nose_morphology0.94782040
97MP0001145_abnormal_male_reproductive0.94203144
98MP0002060_abnormal_skin_morphology0.93852420
99MP0000750_abnormal_muscle_regeneration0.93473237
100MP0003879_abnormal_hair_cell0.93058439
101MP0005666_abnormal_adipose_tissue0.92483964
102MP0003122_maternal_imprinting0.92341233
103MP0003121_genomic_imprinting0.91965068
104MP0009379_abnormal_foot_pigmentation0.91669413
105MP0002089_abnormal_postnatal_growth/wei0.90952407
106MP0010630_abnormal_cardiac_muscle0.90457998
107MP0003936_abnormal_reproductive_system0.89897217
108MP0001286_abnormal_eye_development0.89830199
109MP0002697_abnormal_eye_size0.89797601
110MP0002210_abnormal_sex_determination0.88900290
111MP0002088_abnormal_embryonic_growth/wei0.88481084
112MP0009278_abnormal_bone_marrow0.88135562
113MP0005409_darkened_coat_color0.87150150
114MP0003984_embryonic_growth_retardation0.86505804
115MP0004019_abnormal_vitamin_homeostasis0.85008322
116MP0000377_abnormal_hair_follicle0.84951581
117MP0009931_abnormal_skin_appearance0.84776945
118MP0009703_decreased_birth_body0.84215384
119MP0003453_abnormal_keratinocyte_physiol0.83267779
120MP0003045_fibrosis0.81808256
121MP0000579_abnormal_nail_morphology0.81018228
122MP0002177_abnormal_outer_ear0.80856149
123MP0002116_abnormal_craniofacial_bone0.80728417
124MP0002282_abnormal_trachea_morphology0.80420568
125MP0002092_abnormal_eye_morphology0.79535707
126MP0002925_abnormal_cardiovascular_devel0.79250539
127MP0003567_abnormal_fetal_cardiomyocyte0.78686478
128MP0002932_abnormal_joint_morphology0.77979598
129MP0001915_intracranial_hemorrhage0.77970032
130MP0003861_abnormal_nervous_system0.77129541
131MP0010771_integument_phenotype0.75956476
132MP0000367_abnormal_coat/_hair0.75503947
133MP0001243_abnormal_dermal_layer0.75268376
134MP0004233_abnormal_muscle_weight0.72796552
135MP0009250_abnormal_appendicular_skeleto0.72501997
136MP0000003_abnormal_adipose_tissue0.71793288
137MP0005330_cardiomyopathy0.71117947
138MP0001764_abnormal_homeostasis0.71014542
139MP0005375_adipose_tissue_phenotype0.69808960
140MP0010307_abnormal_tumor_latency0.67736011
141MP0005508_abnormal_skeleton_morphology0.66035089
142MP0001727_abnormal_embryo_implantation0.65523251
143MP0000653_abnormal_sex_gland0.64188919
144MP0001919_abnormal_reproductive_system0.62308523
145MP0005197_abnormal_uvea_morphology0.59030277

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)6.06108939
2Abdominal situs inversus (HP:0003363)5.02145920
3Abnormality of abdominal situs (HP:0011620)5.02145920
4Hypoplastic left heart (HP:0004383)4.44676615
5Milia (HP:0001056)4.24740156
6Anomalous pulmonary venous return (HP:0010772)3.99711770
7Micronodular cirrhosis (HP:0001413)3.84927376
8Ridged nail (HP:0001807)3.80213456
9Ankle contracture (HP:0006466)3.79668408
10Transposition of the great arteries (HP:0001669)3.77907117
11Abnormal connection of the cardiac segments (HP:0011545)3.77907117
12Abnormal ventriculo-arterial connection (HP:0011563)3.77907117
13Stridor (HP:0010307)3.76331037
14Atrophic scars (HP:0001075)3.74868155
15Male infertility (HP:0003251)3.68830377
16Hypoplastic heart (HP:0001961)3.62677746
17Progressive muscle weakness (HP:0003323)3.49480882
18Abnormality of the pulmonary veins (HP:0011718)3.46548535
19Protrusio acetabuli (HP:0003179)3.37578771
20Bulbar palsy (HP:0001283)3.35787854
21Abnormal tarsal ossification (HP:0008369)3.35295838
22Shallow orbits (HP:0000586)3.30723848
23Diaphragmatic weakness (HP:0009113)3.25148761
24Reticulocytopenia (HP:0001896)3.17176236
25Metaphyseal cupping (HP:0003021)3.16643140
26Dry hair (HP:0011359)3.16288632
27Fragile nails (HP:0001808)3.13346706
28Hypotrichosis (HP:0001006)3.12597293
29Gonadal dysgenesis (HP:0000133)3.11034897
30Nail dystrophy (HP:0008404)3.10446456
31Blepharitis (HP:0000498)3.07051272
32Short 4th metacarpal (HP:0010044)3.04307433
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.04307433
34Female pseudohermaphroditism (HP:0010458)3.03245100
35Selective tooth agenesis (HP:0001592)2.98060451
36Pili torti (HP:0003777)2.93342403
37Delayed epiphyseal ossification (HP:0002663)2.91166075
38Choanal stenosis (HP:0000452)2.91164611
39Cervical subluxation (HP:0003308)2.88990819
40Abnormal sex determination (HP:0012244)2.86304895
41Sex reversal (HP:0012245)2.86304895
42Trismus (HP:0000211)2.76564296
43Plantar hyperkeratosis (HP:0007556)2.75792232
44Morphological abnormality of the middle ear (HP:0008609)2.74690977
45Pallor (HP:0000980)2.74046644
46Basal cell carcinoma (HP:0002671)2.73124688
47Abnormality of male internal genitalia (HP:0000022)2.67957241
48Hypoplastic pelvis (HP:0008839)2.66336280
49Macrocytic anemia (HP:0001972)2.65948684
50Bronchomalacia (HP:0002780)2.63751877
51Bilateral microphthalmos (HP:0007633)2.62949214
52Squamous cell carcinoma (HP:0002860)2.60721664
53Esophageal varix (HP:0002040)2.56746446
54Fragile skin (HP:0001030)2.54548987
55Renal duplication (HP:0000075)2.50649500
56Ulnar bowing (HP:0003031)2.49526847
57Premature rupture of membranes (HP:0001788)2.49075672
58Abnormality of the fetal cardiovascular system (HP:0010948)2.48062823
59Abnormal umbilical cord blood vessels (HP:0011403)2.48062823
60Single umbilical artery (HP:0001195)2.48062823
61Asymmetry of the thorax (HP:0001555)2.47405181
62Testicular atrophy (HP:0000029)2.46634505
63Microvesicular hepatic steatosis (HP:0001414)2.43495718
64Preauricular pit (HP:0004467)2.42500523
65Periauricular skin pits (HP:0100277)2.42500523
66Myopathic facies (HP:0002058)2.42230769
67Sparse scalp hair (HP:0002209)2.41975454
6811 pairs of ribs (HP:0000878)2.41972742
69Flat acetabular roof (HP:0003180)2.41204060
70Increased connective tissue (HP:0009025)2.37456229
71Abnormality of the 4th metacarpal (HP:0010012)2.32917383
72Bladder diverticulum (HP:0000015)2.29261837
73Missing ribs (HP:0000921)2.28538756
74Bicornuate uterus (HP:0000813)2.27234173
75Abnormal vertebral ossification (HP:0100569)2.24334635
76Biconcave vertebral bodies (HP:0004586)2.22611177
77Aplasia/Hypoplasia of the breasts (HP:0010311)2.19456242
78Ovarian neoplasm (HP:0100615)2.18931423
79Absent eyebrow (HP:0002223)2.18748010
80Abnormality of the distal phalanx of the thumb (HP:0009617)2.17333850
81Hyperacusis (HP:0010780)2.16888942
82Upper limb amyotrophy (HP:0009129)2.16229797
83Distal upper limb amyotrophy (HP:0007149)2.16229797
84Down-sloping shoulders (HP:0200021)2.15080052
85Breast aplasia (HP:0100783)2.14355149
86Premature loss of primary teeth (HP:0006323)2.10748971
87Beaking of vertebral bodies (HP:0004568)2.08139525
88Villous atrophy (HP:0011473)2.04680695
89Abnormality of small intestinal villus morphology (HP:0011472)2.04680695
90Abnormal foot bone ossification (HP:0010675)2.04165210
91Deviation of the thumb (HP:0009603)2.03537045
92Ragged-red muscle fibers (HP:0003200)2.02983566
93Difficulty climbing stairs (HP:0003551)2.01802412
94Abnormal hair laboratory examination (HP:0003328)2.01246625
95Abnormality of cochlea (HP:0000375)2.00933420
96Pseudobulbar signs (HP:0002200)2.00317586
97Abnormality of the distal phalanges of the toes (HP:0010182)1.98112232
98Acanthosis nigricans (HP:0000956)1.94907622
99Hand muscle atrophy (HP:0009130)1.94259922
100Renal tubular acidosis (HP:0001947)1.92848057
101Abnormality of the calcaneus (HP:0008364)1.92605680
102Lip pit (HP:0100267)1.91011328
103Vertebral compression fractures (HP:0002953)1.90926646
104Breast hypoplasia (HP:0003187)1.89652275
105Mesangial abnormality (HP:0001966)1.89313884
106Primary adrenal insufficiency (HP:0008207)1.89290837
107Conical tooth (HP:0000698)1.86303707
108Cerebral aneurysm (HP:0004944)1.85450294
109Anonychia (HP:0001798)1.85073318
110Abnormality of the lacrimal duct (HP:0011481)1.85034334
111Renovascular hypertension (HP:0100817)1.84883904
112Right ventricular cardiomyopathy (HP:0011663)1.84801518
113Abnormality of cells of the erythroid lineage (HP:0012130)1.84799848
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84160379
115Underdeveloped supraorbital ridges (HP:0009891)1.83880107
116Irregular epiphyses (HP:0010582)1.83550563
117Germ cell neoplasia (HP:0100728)1.83489082
118Vitreoretinal degeneration (HP:0000655)1.83306409
119Testicular neoplasm (HP:0010788)1.83191979
120Abnormality of the lower motor neuron (HP:0002366)1.80378000
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.80002159
122Abnormal hemoglobin (HP:0011902)1.79567146
123Spinal rigidity (HP:0003306)1.79035068
124Broad thumb (HP:0011304)1.78280087
125Abnormality of carpal bone ossification (HP:0006257)1.77828814
126Resting tremor (HP:0002322)1.77654457
127Flared metaphyses (HP:0003015)1.77193967
128Abnormality of the aortic arch (HP:0012303)1.77143499
129Flattened epiphyses (HP:0003071)1.76343398
130Absent eyelashes (HP:0000561)1.76193552
131Abnormality of the parietal bone (HP:0002696)1.75849236
132Broad forehead (HP:0000337)1.75588412
133Calcaneovalgus deformity (HP:0001848)1.75580391
134Anosmia (HP:0000458)1.75553546
135Skin pits (HP:0100276)1.74958994
136Long palpebral fissure (HP:0000637)1.74100653
137Proximal placement of thumb (HP:0009623)1.73709527
138Abnormality of incisor morphology (HP:0011063)1.73562536
139Tongue fasciculations (HP:0001308)1.73519113
140Woolly hair (HP:0002224)1.72360970
141Abnormality of the vocal cords (HP:0008777)1.72299205
142Pointed chin (HP:0000307)1.71015759
143Abnormality of dentin (HP:0010299)1.70337675
144Fused cervical vertebrae (HP:0002949)1.69484611
145Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69291414
146Rectal prolapse (HP:0002035)1.69288767
147Sprengel anomaly (HP:0000912)1.68506889
148Premature ovarian failure (HP:0008209)1.68273061
149Abnormality of the pubic bones (HP:0003172)1.68076840
150Esophageal atresia (HP:0002032)1.67244553
151Male pseudohermaphroditism (HP:0000037)1.67178415
152Aplasia/hypoplasia of the uterus (HP:0008684)1.66095348
153Aplasia/hypoplasia of the humerus (HP:0006507)1.65441808
154Epiphyseal dysplasia (HP:0002656)1.65319607
155Broad distal phalanx of finger (HP:0009836)1.64650294
156Tracheal stenosis (HP:0002777)1.64285521
157Ventricular tachycardia (HP:0004756)1.63200231
158Hypoplasia of the uterus (HP:0000013)1.62897587
159Clumsiness (HP:0002312)1.62844706
160Ankyloglossia (HP:0010296)1.62182933
161Abnormal lung lobation (HP:0002101)1.61979569
162Insomnia (HP:0100785)1.61813362
163Short humerus (HP:0005792)1.61707942
164Abnormality of the umbilical cord (HP:0010881)1.61672186
165Abnormality of dental color (HP:0011073)1.61582094
166Hypergonadotropic hypogonadism (HP:0000815)1.61573050
167Achilles tendon contracture (HP:0001771)1.61506958
168Abnormality of the nasal septum (HP:0000419)1.61329119
169Bell-shaped thorax (HP:0001591)1.61150661
170Slender long bone (HP:0003100)1.60738318
171Glossoptosis (HP:0000162)1.59123095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME27.07012998
2EPHA26.03330821
3BUB14.33278971
4CDK124.23734353
5MAP2K23.94649396
6PDK23.38791640
7RPS6KB22.76419244
8TRIB32.72232516
9SMG12.34305274
10PAK42.15203743
11EPHB22.10861118
12NEK22.07545493
13CDK72.07013727
14RIPK11.98234785
15TESK11.95435438
16TTN1.94395931
17LATS21.90107418
18TYRO31.81510206
19STK101.76312660
20MST1R1.76301286
21PTK61.73060382
22MAP3K101.70206915
23PKN21.67613391
24VRK21.63294723
25TNK21.56936633
26BRD41.55636202
27TESK21.50570249
28ICK1.47293343
29MAP2K11.46525518
30MAP3K31.46207038
31LATS11.44873086
32PTK21.42245081
33WEE11.40038658
34MAP3K81.39805152
35STK381.36050659
36TLK11.28380282
37MAP3K21.27832814
38BMX1.26908202
39PDGFRA1.22354795
40STK391.21491449
41PRKD31.19550156
42STK161.18881811
43PLK41.15434631
44DDR21.15421493
45SCYL21.12996649
46RPS6KA61.12895387
47PRKCI1.03769120
48MAP3K71.01233141
49EEF2K1.00705571
50OXSR11.00253746
51DAPK30.99350183
52MTOR0.98616771
53LRRK20.96557615
54PRPF4B0.95984835
55FER0.95138090
56CAMK2B0.93188916
57CDC70.92008946
58CDC42BPA0.91791342
59MAP2K60.91741436
60CDK40.89970404
61PAK10.88358630
62MAPKAPK30.88358580
63AURKB0.85938496
64MAPK110.85511975
65AURKA0.84826998
66MAP3K110.84285645
67PDPK10.84020610
68MET0.80927759
69PLK10.80618902
70DAPK10.80233377
71FGFR10.79739513
72STK38L0.79384644
73ABL20.78960597
74LIMK10.78183843
75CAMK2G0.77852692
76ILK0.77643696
77TSSK60.75997137
78MAP3K60.74560206
79IRAK30.74497054
80ERN10.70560343
81NME10.67950293
82MAPK150.67450598
83MAP4K10.64281996
84TTK0.63995049
85GRK60.62903358
86CAMK2D0.61917623
87STK30.58974425
88DYRK30.58285938
89RPS6KA40.58244581
90AKT20.58183823
91PRKD20.56954157
92SIK10.55415210
93ERBB20.55153562
94BCKDK0.55032233
95ALK0.54810676
96HIPK20.54042743
97CSNK1E0.53276554
98TGFBR10.52869748
99STK40.51052339
100PAK20.49843601
101WNK40.49796805
102NEK10.48495859
103KSR20.46532889
104FLT30.46393803
105MAP2K30.45756702
106MAPKAPK20.45487870
107PASK0.44761624
108MARK20.44444406
109MATK0.43770894
110BTK0.43282923
111CHUK0.43257521
112CHEK10.41485020
113CHEK20.39620531
114CDK60.39082208
115DYRK1B0.36861571
116MAP3K10.36659066
117TAOK20.36639269
118IKBKB0.36555496
119MINK10.36518625
120ROCK20.35252302
121ATR0.35180111
122CDK20.35151494
123PRKG20.34554145
124MAPK10.34533911
125CDK90.33921993
126BRAF0.33839718
127DAPK20.33665426
128CSF1R0.33561889
129RPS6KA20.33547337
130MAPK120.33345141
131PRKDC0.31912250
132MAPK40.30492130
133MYLK0.29814316
134STK240.29798118
135CDK190.29511309
136RPS6KA10.27445393
137PBK0.27258579
138ROCK10.27178338
139PAK30.24824707
140RPS6KC10.24380756
141RPS6KL10.24380756
142DMPK0.23499437
143CDK10.22807454
144SRC0.22533643

Predicted pathways (KEGG)

RankGene SetZ-score
1* Hedgehog signaling pathway_Homo sapiens_hsa043404.61272059
2* Basal cell carcinoma_Homo sapiens_hsa052174.59945595
3Folate biosynthesis_Homo sapiens_hsa007903.57833431
4* Hippo signaling pathway_Homo sapiens_hsa043903.19220332
5* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.44037714
6TGF-beta signaling pathway_Homo sapiens_hsa043502.41843012
7Galactose metabolism_Homo sapiens_hsa000522.37819353
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.28444993
9p53 signaling pathway_Homo sapiens_hsa041152.20979996
10Ribosome_Homo sapiens_hsa030102.19223896
11Pentose phosphate pathway_Homo sapiens_hsa000302.16824652
12ECM-receptor interaction_Homo sapiens_hsa045122.15202036
13Tight junction_Homo sapiens_hsa045302.11779143
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.01129310
15* Proteoglycans in cancer_Homo sapiens_hsa052051.98566254
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93578704
17Adherens junction_Homo sapiens_hsa045201.89689205
18Melanoma_Homo sapiens_hsa052181.89593108
19Spliceosome_Homo sapiens_hsa030401.88941430
20Small cell lung cancer_Homo sapiens_hsa052221.87573022
21Other glycan degradation_Homo sapiens_hsa005111.82651318
22Fructose and mannose metabolism_Homo sapiens_hsa000511.81786276
23* Melanogenesis_Homo sapiens_hsa049161.81053230
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.80045055
25DNA replication_Homo sapiens_hsa030301.77145674
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.76663836
27Fatty acid elongation_Homo sapiens_hsa000621.75530877
28Cell cycle_Homo sapiens_hsa041101.74351562
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72414486
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72178568
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.68211649
32Focal adhesion_Homo sapiens_hsa045101.66904670
33Pyruvate metabolism_Homo sapiens_hsa006201.64644144
34Bladder cancer_Homo sapiens_hsa052191.63282136
35Vibrio cholerae infection_Homo sapiens_hsa051101.62612744
36RNA transport_Homo sapiens_hsa030131.60738904
37* Wnt signaling pathway_Homo sapiens_hsa043101.55999293
38Amoebiasis_Homo sapiens_hsa051461.55233615
39* Pathways in cancer_Homo sapiens_hsa052001.53549929
40Mismatch repair_Homo sapiens_hsa034301.48778895
41* HTLV-I infection_Homo sapiens_hsa051661.45600671
42Thyroid cancer_Homo sapiens_hsa052161.40328539
43Vitamin digestion and absorption_Homo sapiens_hsa049771.38859417
44MicroRNAs in cancer_Homo sapiens_hsa052061.38416574
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.32582777
46N-Glycan biosynthesis_Homo sapiens_hsa005101.32078872
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28738739
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27475068
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23037662
50Glutathione metabolism_Homo sapiens_hsa004801.22707521
51Notch signaling pathway_Homo sapiens_hsa043301.18740991
52Arginine biosynthesis_Homo sapiens_hsa002201.17277394
53Carbon metabolism_Homo sapiens_hsa012001.14690287
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14171007
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.13200862
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13073774
57Phenylalanine metabolism_Homo sapiens_hsa003601.12377939
58Collecting duct acid secretion_Homo sapiens_hsa049661.10311045
59Oocyte meiosis_Homo sapiens_hsa041141.08451887
60Sulfur relay system_Homo sapiens_hsa041221.06627246
61Proteasome_Homo sapiens_hsa030501.04564334
62Endometrial cancer_Homo sapiens_hsa052131.03971561
63Gap junction_Homo sapiens_hsa045401.02249237
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01713388
65Rap1 signaling pathway_Homo sapiens_hsa040150.99690651
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98822494
67Protein digestion and absorption_Homo sapiens_hsa049740.97351364
68Axon guidance_Homo sapiens_hsa043600.96983011
69Viral myocarditis_Homo sapiens_hsa054160.96524429
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92694197
71Base excision repair_Homo sapiens_hsa034100.92336666
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90604925
73One carbon pool by folate_Homo sapiens_hsa006700.90531266
74Oxidative phosphorylation_Homo sapiens_hsa001900.90485486
75Nucleotide excision repair_Homo sapiens_hsa034200.85692966
76Apoptosis_Homo sapiens_hsa042100.85212176
77mRNA surveillance pathway_Homo sapiens_hsa030150.85146974
78Non-homologous end-joining_Homo sapiens_hsa034500.84616387
79Arginine and proline metabolism_Homo sapiens_hsa003300.81421624
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78782103
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77077495
82RNA polymerase_Homo sapiens_hsa030200.76520441
83Chronic myeloid leukemia_Homo sapiens_hsa052200.76003042
84Viral carcinogenesis_Homo sapiens_hsa052030.74932811
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74078007
86Colorectal cancer_Homo sapiens_hsa052100.73366586
87VEGF signaling pathway_Homo sapiens_hsa043700.72258373
88Shigellosis_Homo sapiens_hsa051310.71991895
89Salmonella infection_Homo sapiens_hsa051320.68252656
90Renal cell carcinoma_Homo sapiens_hsa052110.67681219
91Toxoplasmosis_Homo sapiens_hsa051450.65852849
92Lysosome_Homo sapiens_hsa041420.65768848
93Inositol phosphate metabolism_Homo sapiens_hsa005620.65417709
94Glioma_Homo sapiens_hsa052140.63460762
95Prostate cancer_Homo sapiens_hsa052150.58368906
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58335175
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56789536
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.54791150
99Acute myeloid leukemia_Homo sapiens_hsa052210.54283645
100Sulfur metabolism_Homo sapiens_hsa009200.53563434
101Lysine degradation_Homo sapiens_hsa003100.53053497
102Pyrimidine metabolism_Homo sapiens_hsa002400.52934215
103Epstein-Barr virus infection_Homo sapiens_hsa051690.50875157
104Homologous recombination_Homo sapiens_hsa034400.50791361
105Metabolic pathways_Homo sapiens_hsa011000.50787406
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50160185
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50106304
108Biosynthesis of amino acids_Homo sapiens_hsa012300.50030536
109Insulin signaling pathway_Homo sapiens_hsa049100.49413558
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48144081
111mTOR signaling pathway_Homo sapiens_hsa041500.47928427
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47013832
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46888354
114Huntingtons disease_Homo sapiens_hsa050160.45050427
115B cell receptor signaling pathway_Homo sapiens_hsa046620.44077207
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43175345
117Estrogen signaling pathway_Homo sapiens_hsa049150.43150313
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42914666
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42353090
120Selenocompound metabolism_Homo sapiens_hsa004500.40275501
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.39175988
122Ras signaling pathway_Homo sapiens_hsa040140.38795376
123AMPK signaling pathway_Homo sapiens_hsa041520.38490037
124Pancreatic cancer_Homo sapiens_hsa052120.37250774
125MAPK signaling pathway_Homo sapiens_hsa040100.36671513
126HIF-1 signaling pathway_Homo sapiens_hsa040660.36481006
127Alzheimers disease_Homo sapiens_hsa050100.36433800
128Antigen processing and presentation_Homo sapiens_hsa046120.35570592
129Glucagon signaling pathway_Homo sapiens_hsa049220.33517648
130Non-small cell lung cancer_Homo sapiens_hsa052230.33221754
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33003577
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32848612
133Dorso-ventral axis formation_Homo sapiens_hsa043200.32765963
134Dilated cardiomyopathy_Homo sapiens_hsa054140.32761928
135Endocytosis_Homo sapiens_hsa041440.32182218
136Hepatitis C_Homo sapiens_hsa051600.31921153
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31450125
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30974603
139Herpes simplex infection_Homo sapiens_hsa051680.30453097
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.30124547
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29982803
142Prion diseases_Homo sapiens_hsa050200.29710038
143Thyroid hormone synthesis_Homo sapiens_hsa049180.28549170
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27583692

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »