WNT7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-independent telencephalic tangential migration (GO:0021826)6.98665872
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.98665872
3locomotory exploration behavior (GO:0035641)5.70550039
4pyrimidine nucleobase catabolic process (GO:0006208)5.58110845
5negative regulation of oligodendrocyte differentiation (GO:0048715)5.32760414
6sodium ion export (GO:0071436)5.21922701
7cellular potassium ion homeostasis (GO:0030007)5.19520235
8neuronal stem cell maintenance (GO:0097150)4.89981140
9gamma-aminobutyric acid transport (GO:0015812)4.82310707
10nucleobase catabolic process (GO:0046113)4.80437408
11mating behavior (GO:0007617)4.79299620
12peristalsis (GO:0030432)4.74831211
13neuron fate determination (GO:0048664)4.71665470
14vocalization behavior (GO:0071625)4.48642952
15cellular sodium ion homeostasis (GO:0006883)4.44944804
16negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.42000107
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.41015865
18dopamine transport (GO:0015872)4.39708720
19neuron cell-cell adhesion (GO:0007158)4.38973522
20adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.37592497
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.32806269
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32050931
23limb bud formation (GO:0060174)4.30767270
24regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.11121528
25regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.11121528
26cell communication by electrical coupling (GO:0010644)4.05112824
27regulation of neurotransmitter uptake (GO:0051580)4.01594925
28glutamate receptor signaling pathway (GO:0007215)3.98647409
29startle response (GO:0001964)3.98608767
30auditory behavior (GO:0031223)3.97221169
31layer formation in cerebral cortex (GO:0021819)3.97079280
32exploration behavior (GO:0035640)3.94881236
33negative regulation of astrocyte differentiation (GO:0048712)3.94825021
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94764992
35postsynaptic membrane organization (GO:0001941)3.93226564
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87181867
37phasic smooth muscle contraction (GO:0014821)3.85515779
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85228054
39negative regulation of sodium ion transport (GO:0010766)3.84362023
40behavioral response to cocaine (GO:0048148)3.84087436
41maternal behavior (GO:0042711)3.83762247
42neural tube formation (GO:0001841)3.74764203
43regulation of glutamate receptor signaling pathway (GO:1900449)3.72852351
44synaptic transmission, glutamatergic (GO:0035249)3.71453026
45* cerebellar granule cell differentiation (GO:0021707)3.71138759
46neurotransmitter-gated ion channel clustering (GO:0072578)3.70555706
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69575951
48potassium ion import (GO:0010107)3.68906307
49phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.68190279
50regulation of development, heterochronic (GO:0040034)3.64628944
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.61986037
52adult walking behavior (GO:0007628)3.59741945
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58997501
54sequestering of actin monomers (GO:0042989)3.57318763
55response to auditory stimulus (GO:0010996)3.56987830
56positive regulation of Notch signaling pathway (GO:0045747)3.56377303
57neuronal action potential propagation (GO:0019227)3.54777894
58astrocyte development (GO:0014002)3.53984535
59positive regulation of synapse maturation (GO:0090129)3.53185625
60cell morphogenesis involved in neuron differentiation (GO:0048667)3.52174802
61synaptic vesicle exocytosis (GO:0016079)3.51689453
62regulation of timing of cell differentiation (GO:0048505)3.51317835
63L-amino acid import (GO:0043092)3.51299079
64tolerance induction (GO:0002507)3.50483143
65C4-dicarboxylate transport (GO:0015740)3.48868223
66alanine transport (GO:0032328)3.48226796
67central nervous system myelination (GO:0022010)3.45841295
68axon ensheathment in central nervous system (GO:0032291)3.45841295
69amino acid import (GO:0043090)3.45836586
70regulation of oligodendrocyte differentiation (GO:0048713)3.42440068
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42204372
72regulation of mesenchymal cell apoptotic process (GO:2001053)3.40739317
73innervation (GO:0060384)3.37031925
74transmission of nerve impulse (GO:0019226)3.36945238
75parental behavior (GO:0060746)3.36430334
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35773241
77establishment of mitochondrion localization (GO:0051654)3.35145932
78neuronal action potential (GO:0019228)3.35094521
79regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33432177
80retinal ganglion cell axon guidance (GO:0031290)3.30598153
81potassium ion homeostasis (GO:0055075)3.24908787
82hemidesmosome assembly (GO:0031581)3.24797715
83striatum development (GO:0021756)3.21740361
84* neurotransmitter secretion (GO:0007269)3.21618275
85ephrin receptor signaling pathway (GO:0048013)3.21043656
86neuron recognition (GO:0008038)3.19480328
87nephron tubule morphogenesis (GO:0072078)3.18594060
88nephron epithelium morphogenesis (GO:0072088)3.18594060
89glutamate secretion (GO:0014047)3.18321306
90* lens fiber cell development (GO:0070307)3.17642938
91dendrite morphogenesis (GO:0048813)3.17426970
92regulation of astrocyte differentiation (GO:0048710)3.17038907
93negative regulation of smoothened signaling pathway (GO:0045879)3.14575810
94neuron-neuron synaptic transmission (GO:0007270)3.13873819
95synaptic vesicle maturation (GO:0016188)3.13518429
96response to pheromone (GO:0019236)3.11860683
97mechanosensory behavior (GO:0007638)3.11207411
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10450879
99regulation of neuronal synaptic plasticity (GO:0048168)3.10450395
100regulation of synaptic transmission, glutamatergic (GO:0051966)3.08809685
101glial cell proliferation (GO:0014009)3.08220717
102regulation of cardiac muscle cell contraction (GO:0086004)3.07479143
103* positive regulation of synapse assembly (GO:0051965)3.06605639
104protein localization to synapse (GO:0035418)3.04190971
105axonal fasciculation (GO:0007413)3.03291505
106neurotransmitter uptake (GO:0001504)3.02274567
107renal system development (GO:0072001)3.02031820
108negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01577667
109L-serine transport (GO:0015825)3.01005771
110pattern specification involved in kidney development (GO:0061004)3.00769198
111behavioral response to nicotine (GO:0035095)3.00378296
112synaptic transmission, dopaminergic (GO:0001963)2.99832452
113regulation of respiratory system process (GO:0044065)2.96928651
114dendritic spine morphogenesis (GO:0060997)2.94934833
115cerebral cortex radially oriented cell migration (GO:0021799)2.94783331
116positive regulation of mitochondrial fission (GO:0090141)2.93257230
117presynaptic membrane assembly (GO:0097105)2.92609688
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92532047
119neural crest cell development (GO:0014032)2.92323571
120neuromuscular process controlling balance (GO:0050885)2.91266636
121regulation of synapse maturation (GO:0090128)2.91234006
122proline transport (GO:0015824)2.91176190
123long-term synaptic potentiation (GO:0060291)2.90937183
124forebrain neuron differentiation (GO:0021879)2.90387510
125membrane hyperpolarization (GO:0060081)2.89660974
126gamma-aminobutyric acid signaling pathway (GO:0007214)2.88439364
127regulation of synapse structural plasticity (GO:0051823)2.88114174
128synapse assembly (GO:0007416)2.87738794
129fucosylation (GO:0036065)2.87616800
130cochlea development (GO:0090102)2.86479274
131regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85844353
132cell migration in hindbrain (GO:0021535)2.84252866
133regulation of synaptic vesicle exocytosis (GO:2000300)2.84084170
134long-term memory (GO:0007616)2.84008686
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83556093
136lung epithelium development (GO:0060428)2.83072365
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80461170
138negative regulation of glial cell differentiation (GO:0045686)2.78857265
139establishment of nucleus localization (GO:0040023)2.78648058
140regulation of dendritic spine morphogenesis (GO:0061001)2.77312951
141catecholamine transport (GO:0051937)2.75392100
142prepulse inhibition (GO:0060134)2.74315938
143negative regulation of glial cell proliferation (GO:0060253)2.74303066
144presynaptic membrane organization (GO:0097090)2.73873224
145negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.73332405
146positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.73229386
147behavioral defense response (GO:0002209)2.73169474
148behavioral fear response (GO:0001662)2.73169474
149regulation of postsynaptic membrane potential (GO:0060078)2.71942547
150radial glial cell differentiation (GO:0060019)2.71466499
151* neurotransmitter transport (GO:0006836)2.71068286
152protein K11-linked deubiquitination (GO:0035871)2.70852634
153negative regulation of axon extension (GO:0030517)2.70264286
154regulation of secondary heart field cardioblast proliferation (GO:0003266)2.69222891
155regulation of cardioblast proliferation (GO:0003264)2.69222891
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.68648499
157* synapse organization (GO:0050808)2.68613570
158regulation of beta-amyloid formation (GO:1902003)2.68280788
159regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67601553
160lateral sprouting from an epithelium (GO:0060601)2.66547080
161regulation of respiratory gaseous exchange (GO:0043576)2.66348424
162* regulation of neurotransmitter levels (GO:0001505)2.65768250
163positive regulation of dendritic spine morphogenesis (GO:0061003)2.65492121
164positive regulation of oligodendrocyte differentiation (GO:0048714)2.63864747
165establishment of tissue polarity (GO:0007164)2.63276009
166establishment of planar polarity (GO:0001736)2.63276009
167cranial nerve development (GO:0021545)2.63205039
168nephron tubule formation (GO:0072079)2.63088240
169L-fucose catabolic process (GO:0042355)2.59189845
170fucose catabolic process (GO:0019317)2.59189845
171L-fucose metabolic process (GO:0042354)2.59189845
172inner ear receptor stereocilium organization (GO:0060122)2.57296107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.09599963
2EZH2_22144423_ChIP-Seq_EOC_Human4.50560034
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15545958
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05850640
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02008314
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90861572
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90861572
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87259068
9GBX2_23144817_ChIP-Seq_PC3_Human2.79572244
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.78572758
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75330802
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.74648784
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.73369920
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71455594
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.65144786
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63073157
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49436591
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.44797851
19AR_21572438_ChIP-Seq_LNCaP_Human2.36243997
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.34863372
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33973155
22DROSHA_22980978_ChIP-Seq_HELA_Human2.29353237
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22563869
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11527446
25REST_21632747_ChIP-Seq_MESCs_Mouse2.05931856
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.00113816
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92216241
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85955666
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78328860
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72657120
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.72577288
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.70688519
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.69840871
34* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69773901
35* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64589927
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62073558
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59992177
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.56113201
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.53945147
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52594785
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50736883
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46823694
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43869716
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.41979358
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41772504
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40947413
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38424740
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37440765
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36545897
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.36173081
51IGF1R_20145208_ChIP-Seq_DFB_Human1.34294676
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34025197
53SMAD4_21799915_ChIP-Seq_A2780_Human1.31843013
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.31576029
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29788755
56VDR_22108803_ChIP-Seq_LS180_Human1.23752794
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23447829
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22388103
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19763095
60* AR_25329375_ChIP-Seq_VCAP_Human1.18051568
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17862057
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17531755
63* ZNF274_21170338_ChIP-Seq_K562_Hela1.17320321
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16279845
65EWS_26573619_Chip-Seq_HEK293_Human1.16154881
66AR_19668381_ChIP-Seq_PC3_Human1.16102330
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16031484
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14910058
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.14474402
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13981697
71KDM2B_26808549_Chip-Seq_K562_Human1.12819704
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.12335145
73* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11203620
74FUS_26573619_Chip-Seq_HEK293_Human1.10801768
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10538200
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10039692
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.09565769
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09058782
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08578180
80TP53_16413492_ChIP-PET_HCT116_Human1.08540987
81P300_19829295_ChIP-Seq_ESCs_Human1.07834012
82AHR_22903824_ChIP-Seq_MCF-7_Human1.07818947
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.07355339
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07290665
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07027769
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06796842
87* TP53_18474530_ChIP-ChIP_U2OS_Human1.06421231
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05985879
89RXR_22108803_ChIP-Seq_LS180_Human1.05775389
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04263119
91TAF15_26573619_Chip-Seq_HEK293_Human1.03756288
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03095566
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02110634
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02011612
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01604825
96BCAT_22108803_ChIP-Seq_LS180_Human0.99969998
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99962062
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99877244
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.99306129
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98963264
101FLI1_27457419_Chip-Seq_LIVER_Mouse0.98296273
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97606754
103* STAT3_23295773_ChIP-Seq_U87_Human0.96440249
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95732095
105RUNX2_22187159_ChIP-Seq_PCA_Human0.95520743
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95209555
107NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95116682
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94830658
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94830658
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94553400
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.94255736
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94180732
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93734736
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93654963
115EP300_21415370_ChIP-Seq_HL-1_Mouse0.93521267
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93447895
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93199490
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.90709030
119FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90709030
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89952004
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89706315
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89251903
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.89035714
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88254031
125RNF2_27304074_Chip-Seq_NSC_Mouse0.85392362
126ER_23166858_ChIP-Seq_MCF-7_Human0.85259524
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84640752
128TAL1_26923725_Chip-Seq_HPCs_Mouse0.84417150
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83978168
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83691758
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83689401
132JUN_21703547_ChIP-Seq_K562_Human0.82480421
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81783815
134* TCF4_23295773_ChIP-Seq_U87_Human0.81016105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.40103943
2MP0005423_abnormal_somatic_nervous3.80623390
3MP0003880_abnormal_central_pattern3.46354518
4MP0003635_abnormal_synaptic_transmissio3.26787610
5MP0004858_abnormal_nervous_system2.98129966
6MP0004885_abnormal_endolymph2.96191309
7MP0004270_analgesia2.86496134
8MP0009780_abnormal_chondrocyte_physiolo2.63391143
9MP0009046_muscle_twitch2.61717756
10MP0001486_abnormal_startle_reflex2.60171334
11MP0002234_abnormal_pharynx_morphology2.59800566
12MP0002928_abnormal_bile_duct2.54240282
13MP0002063_abnormal_learning/memory/cond2.53058751
14MP0009745_abnormal_behavioral_response2.49721733
15MP0002064_seizures2.44115636
16MP0003329_amyloid_beta_deposits2.30855919
17MP0000778_abnormal_nervous_system2.28722215
18MP0001968_abnormal_touch/_nociception2.27658833
19MP0005084_abnormal_gallbladder_morpholo2.26911434
20MP0002102_abnormal_ear_morphology2.24857681
21MP0002572_abnormal_emotion/affect_behav2.23715059
22MP0002736_abnormal_nociception_after2.19918142
23MP0002653_abnormal_ependyma_morphology2.15904381
24MP0002272_abnormal_nervous_system2.00110677
25MP0008569_lethality_at_weaning1.99372243
26MP0001440_abnormal_grooming_behavior1.98989195
27MP0000579_abnormal_nail_morphology1.89924153
28MP0002067_abnormal_sensory_capabilities1.89345384
29MP0002184_abnormal_innervation1.88676593
30MP0002734_abnormal_mechanical_nocicepti1.87161514
31MP0005377_hearing/vestibular/ear_phenot1.83741281
32MP0003878_abnormal_ear_physiology1.83741281
33MP0003122_maternal_imprinting1.78877856
34MP0002557_abnormal_social/conspecific_i1.77694452
35MP0001485_abnormal_pinna_reflex1.77158906
36MP0003136_yellow_coat_color1.69436846
37MP0002733_abnormal_thermal_nociception1.66043473
38MP0005646_abnormal_pituitary_gland1.63053601
39MP0000467_abnormal_esophagus_morphology1.61224258
40MP0000566_synostosis1.61148723
41MP0003283_abnormal_digestive_organ1.60360814
42MP0003011_delayed_dark_adaptation1.55683023
43MP0001299_abnormal_eye_distance/1.54540590
44MP0000955_abnormal_spinal_cord1.48700070
45MP0009053_abnormal_anal_canal1.47506900
46MP0004742_abnormal_vestibular_system1.46151141
47MP0001501_abnormal_sleep_pattern1.44452615
48MP0003690_abnormal_glial_cell1.44370497
49MP0003634_abnormal_glial_cell1.42135591
50MP0001963_abnormal_hearing_physiology1.41463478
51MP0000049_abnormal_middle_ear1.40771978
52MP0002751_abnormal_autonomic_nervous1.40641346
53MP0002882_abnormal_neuron_morphology1.39983412
54MP0000026_abnormal_inner_ear1.39636722
55MP0002735_abnormal_chemical_nociception1.39276756
56MP0001984_abnormal_olfaction1.38991239
57MP0003941_abnormal_skin_development1.38878054
58MP0002089_abnormal_postnatal_growth/wei1.38129079
59MP0002277_abnormal_respiratory_mucosa1.37986084
60MP0000569_abnormal_digit_pigmentation1.36636794
61MP0002152_abnormal_brain_morphology1.32951076
62MP0001970_abnormal_pain_threshold1.32897013
63MP0009384_cardiac_valve_regurgitation1.30227797
64MP0001502_abnormal_circadian_rhythm1.28753132
65MP0003632_abnormal_nervous_system1.27438174
66MP0003119_abnormal_digestive_system1.26051545
67MP0000762_abnormal_tongue_morphology1.25466925
68MP0003879_abnormal_hair_cell1.24030988
69MP0000383_abnormal_hair_follicle1.21441527
70MP0000537_abnormal_urethra_morphology1.21256766
71MP0000631_abnormal_neuroendocrine_gland1.20947018
72MP0002066_abnormal_motor_capabilities/c1.19333880
73MP0002249_abnormal_larynx_morphology1.17914735
74MP0002282_abnormal_trachea_morphology1.17910178
75MP0002098_abnormal_vibrissa_morphology1.17670387
76MP0004924_abnormal_behavior1.15979695
77MP0005386_behavior/neurological_phenoty1.15979695
78MP0001286_abnormal_eye_development1.14534656
79MP0004133_heterotaxia1.13891460
80MP0001958_emphysema1.12810969
81MP0008789_abnormal_olfactory_epithelium1.10334237
82MP0001293_anophthalmia1.09211914
83MP0005075_abnormal_melanosome_morpholog1.06210725
84MP0006276_abnormal_autonomic_nervous1.03499282
85MP0003631_nervous_system_phenotype1.02051706
86MP0004811_abnormal_neuron_physiology1.02014542
87MP0005167_abnormal_blood-brain_barrier1.00191263
88MP0003861_abnormal_nervous_system0.98277928
89MP0005195_abnormal_posterior_eye0.97739838
90MP0006292_abnormal_olfactory_placode0.97092556
91MP0002752_abnormal_somatic_nervous0.96497487
92MP0003137_abnormal_impulse_conducting0.96335847
93MP0003633_abnormal_nervous_system0.95770212
94MP0004142_abnormal_muscle_tone0.95761524
95MP0000534_abnormal_ureter_morphology0.95274855
96MP0003937_abnormal_limbs/digits/tail_de0.94484923
97MP0005645_abnormal_hypothalamus_physiol0.93952281
98MP0005171_absent_coat_pigmentation0.92903970
99MP0000604_amyloidosis0.92411626
100MP0003115_abnormal_respiratory_system0.92151194
101MP0003938_abnormal_ear_development0.91909066
102MP0001177_atelectasis0.91375803
103MP0002254_reproductive_system_inflammat0.90615553
104MP0001188_hyperpigmentation0.89725472
105MP0010678_abnormal_skin_adnexa0.88373299
106MP0000428_abnormal_craniofacial_morphol0.87636016
107MP0001324_abnormal_eye_pigmentation0.86931438
108MP0006072_abnormal_retinal_apoptosis0.86798509
109MP0002638_abnormal_pupillary_reflex0.85912665
110MP0005391_vision/eye_phenotype0.81761680
111MP0001943_abnormal_respiration0.80730818
112MP0002909_abnormal_adrenal_gland0.79988013
113MP0001529_abnormal_vocalization0.79933624
114MP0004145_abnormal_muscle_electrophysio0.79000974
115MP0002177_abnormal_outer_ear0.78801011
116MP0002229_neurodegeneration0.78481870
117MP0005551_abnormal_eye_electrophysiolog0.78217895
118MP0002697_abnormal_eye_size0.77605712
119MP0001905_abnormal_dopamine_level0.77173427
120MP0005253_abnormal_eye_physiology0.76435670
121MP0005394_taste/olfaction_phenotype0.76155746
122MP0005499_abnormal_olfactory_system0.76155746
123MP0008995_early_reproductive_senescence0.75191384
124MP0000920_abnormal_myelination0.74246429
125MP0005623_abnormal_meninges_morphology0.71412746
126MP0002822_catalepsy0.71336905
127MP0005408_hypopigmentation0.70323596
128MP0003075_altered_response_to0.69726813
129MP0002116_abnormal_craniofacial_bone0.69469018
130MP0003755_abnormal_palate_morphology0.69465834
131MP0004085_abnormal_heartbeat0.69416240
132* MP0009250_abnormal_appendicular_skeleto0.68060617
133MP0003942_abnormal_urinary_system0.67336747

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)5.30668238
2Aplasia involving bones of the upper limbs (HP:0009823)5.14903774
3Aplasia of the phalanges of the hand (HP:0009802)5.14903774
4Aplasia involving bones of the extremities (HP:0009825)5.14903774
5Megalencephaly (HP:0001355)4.88482542
6Diplopia (HP:0000651)4.31625400
7Abnormality of binocular vision (HP:0011514)4.31625400
8Hemiparesis (HP:0001269)4.24875815
9Focal motor seizures (HP:0011153)4.22721555
10Hemiplegia (HP:0002301)3.96902419
11Mixed hearing impairment (HP:0000410)3.92767885
12Myokymia (HP:0002411)3.76738384
13Progressive cerebellar ataxia (HP:0002073)3.64762411
14Lissencephaly (HP:0001339)3.55520247
15Congenital stationary night blindness (HP:0007642)3.49553710
16Cerebellar dysplasia (HP:0007033)3.34415614
17Nuclear cataract (HP:0100018)3.26838198
18Focal seizures (HP:0007359)3.19711815
19True hermaphroditism (HP:0010459)3.11295373
20Action tremor (HP:0002345)3.08623988
21B lymphocytopenia (HP:0010976)2.99878669
22Visual hallucinations (HP:0002367)2.97964810
23Neurofibrillary tangles (HP:0002185)2.96514382
24Dysdiadochokinesis (HP:0002075)2.83381406
25Cerebral inclusion bodies (HP:0100314)2.80837572
26Milia (HP:0001056)2.80418933
27* Humeroradial synostosis (HP:0003041)2.76762521
28* Synostosis involving the elbow (HP:0003938)2.76762521
29Pancreatic cysts (HP:0001737)2.75907985
30Epileptic encephalopathy (HP:0200134)2.75508460
31Abnormality of the middle phalanges of the toes (HP:0010183)2.73862978
32Thickened helices (HP:0000391)2.72793762
33Fragile nails (HP:0001808)2.66573298
34Abnormality of B cell number (HP:0010975)2.63148633
35Pheochromocytoma (HP:0002666)2.62229319
36Pachygyria (HP:0001302)2.61859505
37Specific learning disability (HP:0001328)2.61768109
38Gastrointestinal atresia (HP:0002589)2.61610842
39Zonular cataract (HP:0010920)2.59145382
40Molar tooth sign on MRI (HP:0002419)2.58966748
41Abnormality of midbrain morphology (HP:0002418)2.58966748
42Hyperventilation (HP:0002883)2.56757490
43Coronal craniosynostosis (HP:0004440)2.56415481
44Delayed gross motor development (HP:0002194)2.55805870
45Neuroendocrine neoplasm (HP:0100634)2.49666267
46Abnormality of the labia minora (HP:0012880)2.46530534
47Broad-based gait (HP:0002136)2.43795663
48Chorioretinal atrophy (HP:0000533)2.41321840
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40572497
50Alacrima (HP:0000522)2.39416643
51Supranuclear gaze palsy (HP:0000605)2.39212819
52Optic nerve hypoplasia (HP:0000609)2.39107658
53Gait imbalance (HP:0002141)2.37937716
54Pancreatic fibrosis (HP:0100732)2.35596671
55Abnormal drinking behavior (HP:0030082)2.35412311
56Polydipsia (HP:0001959)2.35412311
57Medial flaring of the eyebrow (HP:0010747)2.30692268
58Peripheral hypomyelination (HP:0007182)2.29391231
59Generalized tonic-clonic seizures (HP:0002069)2.29177733
60Abnormal ciliary motility (HP:0012262)2.28616021
61Bronchomalacia (HP:0002780)2.28179378
62Septo-optic dysplasia (HP:0100842)2.27795811
63Inability to walk (HP:0002540)2.24288213
64Abnormal respiratory epithelium morphology (HP:0012253)2.24210093
65Abnormal respiratory motile cilium morphology (HP:0005938)2.24210093
66Absent/shortened dynein arms (HP:0200106)2.20549132
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.20549132
68Partial agenesis of the corpus callosum (HP:0001338)2.18366288
69Atonic seizures (HP:0010819)2.16763489
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16276899
71Morphological abnormality of the middle ear (HP:0008609)2.15545040
72Potter facies (HP:0002009)2.14940927
73Facial shape deformation (HP:0011334)2.14940927
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14900590
75Hypoplasia of the brainstem (HP:0002365)2.14900590
76Arterial tortuosity (HP:0005116)2.14135555
77Anterior segment dysgenesis (HP:0007700)2.14126822
78Truncal ataxia (HP:0002078)2.09203640
79Spastic tetraplegia (HP:0002510)2.07328137
80Abnormality of alanine metabolism (HP:0010916)2.06705764
81Hyperalaninemia (HP:0003348)2.06705764
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06705764
83Neonatal short-limb short stature (HP:0008921)2.06141343
84Abnormal respiratory motile cilium physiology (HP:0012261)2.04130183
85Congenital primary aphakia (HP:0007707)2.04088166
86Scanning speech (HP:0002168)2.01368069
87Mesangial abnormality (HP:0001966)2.00939741
88Absence seizures (HP:0002121)2.00391307
89Abnormal eating behavior (HP:0100738)2.00083957
90Amblyopia (HP:0000646)1.99982518
91Tetraplegia (HP:0002445)1.99583038
92Depression (HP:0000716)1.98584702
93Increased corneal curvature (HP:0100692)1.97697389
94Keratoconus (HP:0000563)1.97697389
95Dysmetria (HP:0001310)1.97009906
96Hypomagnesemia (HP:0002917)1.95926980
97Anophthalmia (HP:0000528)1.95752668
98Clumsiness (HP:0002312)1.94877073
99Nephrogenic diabetes insipidus (HP:0009806)1.92564700
100Epileptiform EEG discharges (HP:0011182)1.92350171
101Bilateral microphthalmos (HP:0007633)1.92061380
102Status epilepticus (HP:0002133)1.91961297
103Onycholysis (HP:0001806)1.91487325
104Cystic liver disease (HP:0006706)1.91290952
105Alopecia of scalp (HP:0002293)1.90939627
106Ankyloglossia (HP:0010296)1.90008069
107Rib fusion (HP:0000902)1.89066324
108Hypsarrhythmia (HP:0002521)1.89051759
109Intellectual disability, profound (HP:0002187)1.88944864
110Plantar hyperkeratosis (HP:0007556)1.88464346
111* Oligodactyly (HP:0012165)1.87841644
112Sclerocornea (HP:0000647)1.87149349
113Maternal diabetes (HP:0009800)1.86472556
114Febrile seizures (HP:0002373)1.86423470
115Confusion (HP:0001289)1.85518138
116Pendular nystagmus (HP:0012043)1.84872059
117Concave nail (HP:0001598)1.84497670
118Dialeptic seizures (HP:0011146)1.84485271
119Severe muscular hypotonia (HP:0006829)1.84443750
120Limb dystonia (HP:0002451)1.84343323
121Vascular tortuosity (HP:0004948)1.82615860
122Gaze-evoked nystagmus (HP:0000640)1.82310255
123Drooling (HP:0002307)1.82165019
124Excessive salivation (HP:0003781)1.82165019
125Chronic hepatic failure (HP:0100626)1.81461744
126Anxiety (HP:0000739)1.80053147
127Narrow nasal bridge (HP:0000446)1.79829237
128Arnold-Chiari malformation (HP:0002308)1.79788720
129Abnormality of the antihelix (HP:0009738)1.79672000
130IgM deficiency (HP:0002850)1.78629923
131Decreased lacrimation (HP:0000633)1.78170428
132EEG with generalized epileptiform discharges (HP:0011198)1.78051873
133Esophageal atresia (HP:0002032)1.77970726
134Obstructive sleep apnea (HP:0002870)1.76480696
135Anencephaly (HP:0002323)1.76298863
136Atrophic scars (HP:0001075)1.75076590
137* Oligodactyly (hands) (HP:0001180)1.75072802
138Partial duplication of thumb phalanx (HP:0009944)1.74854851
139Hypoplasia of the pons (HP:0012110)1.74757298
140Renal dysplasia (HP:0000110)1.74743651
141Impaired vibration sensation in the lower limbs (HP:0002166)1.74591995
142Athetosis (HP:0002305)1.74148677
143* Split foot (HP:0001839)1.74048084
144Renal tubular acidosis (HP:0001947)1.73750349
145Severe visual impairment (HP:0001141)1.72935351
146Hypoplastic female external genitalia (HP:0012815)1.72284416
147Intention tremor (HP:0002080)1.71467931
148Genetic anticipation (HP:0003743)1.70756898
149Tibial bowing (HP:0002982)1.69522213
150Nephronophthisis (HP:0000090)1.69088837
151Labial hypoplasia (HP:0000066)1.68850415
152Thyroid-stimulating hormone excess (HP:0002925)1.68517273
153Cutaneous syndactyly (HP:0012725)1.67792671
154Poor eye contact (HP:0000817)1.66718589
155Abnormality of the dental pulp (HP:0006479)1.66516472
156Genital tract atresia (HP:0001827)1.66511449
157Abnormal mitochondria in muscle tissue (HP:0008316)1.65282367
158Ankle clonus (HP:0011448)1.65091359
159Insomnia (HP:0100785)1.65037811
160Cutaneous finger syndactyly (HP:0010554)1.64391970
161Lipid accumulation in hepatocytes (HP:0006561)1.63543997
162Mitochondrial inheritance (HP:0001427)1.63495007
163Shallow orbits (HP:0000586)1.61794990
164Stereotypic behavior (HP:0000733)1.61622440
165Fetal akinesia sequence (HP:0001989)1.61345244
166Absent speech (HP:0001344)1.59817712
167Incomplete penetrance (HP:0003829)1.59310061
168Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58449234
169* Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56100715
170Retinal dysplasia (HP:0007973)1.55563557
171Aqueductal stenosis (HP:0002410)1.55458636
172Pointed chin (HP:0000307)1.54287451
173Abnormal social behavior (HP:0012433)1.53931029
174Impaired social interactions (HP:0000735)1.53931029
175Trigonocephaly (HP:0000243)1.51817731
176Polyphagia (HP:0002591)1.50191092
177Anteriorly placed anus (HP:0001545)1.49739482
178Myelomeningocele (HP:0002475)1.49368678
179Progressive inability to walk (HP:0002505)1.47921028
180Spinal canal stenosis (HP:0003416)1.47611970
181Anomalous pulmonary venous return (HP:0010772)1.46377321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.85591370
2CASK3.65002217
3EPHA33.27867775
4NTRK23.24739329
5EPHA43.12624985
6NTRK32.97521594
7MARK12.94411109
8TNIK2.72068535
9MAP3K92.44715264
10PHKG22.37448455
11PHKG12.37448455
12DDR22.25217113
13MAP3K42.16311474
14MINK12.15135965
15ARAF2.14779885
16MAP4K22.02419671
17CSNK1G11.91034291
18PNCK1.89200613
19CSNK1G31.82127325
20KSR11.81306862
21MAPK131.77994908
22MAP2K71.77005011
23CSNK1A1L1.74947070
24SIK11.71609890
25LMTK21.70483912
26NTRK11.68200039
27TYRO31.59242691
28PAK61.57179661
29CAMKK11.56692782
30WNK31.49849962
31PRKD31.48303116
32PINK11.47530817
33EPHB21.41215445
34MUSK1.36672966
35PDGFRA1.36479303
36FGR1.35658017
37RIPK11.34818093
38PRKCI1.33804573
39TAOK31.32661394
40CDK51.30650247
41EPHB11.30462323
42ADRBK21.29481341
43SIK21.29441077
44TSSK61.26496000
45PRPF4B1.25826976
46BMPR1B1.18074205
47UHMK11.17830842
48PAK31.13606568
49KSR21.11588828
50PRKCG1.09237588
51SGK2231.09006972
52SGK4941.09006972
53EPHA21.08815194
54ERBB41.07139890
55SGK21.05008843
56STK381.04504687
57TRIB31.00688681
58PLK20.99251308
59DAPK20.98703877
60CAMK1G0.98618445
61ROCK20.98285328
62ICK0.97781725
63WNK40.97111540
64FER0.96218909
65DYRK1A0.95606756
66VRK10.95387144
67MOS0.94822289
68ROCK10.89356898
69LATS20.88482282
70ADRBK10.88036620
71INSRR0.86462498
72MAP2K40.86172658
73TLK10.84649444
74CAMK2A0.84423912
75TGFBR10.80491050
76GRK10.79705111
77BMX0.78989271
78PTK20.76052040
79RET0.74631084
80LATS10.74612480
81SGK30.73758445
82CDK180.72392042
83FGFR20.71706632
84SGK10.71305493
85SIK30.71185931
86CDK150.70670769
87CAMK2B0.70423583
88NLK0.69728877
89FES0.69071068
90CDK140.68935444
91CAMKK20.66032649
92FGFR10.66013942
93PRKCE0.63936522
94MAP3K130.62769839
95GRK50.62456779
96DYRK20.61021071
97PTK2B0.60364721
98CSNK1A10.59168101
99CDK11A0.58986679
100MAP3K120.58779109
101PRKCZ0.58478055
102CSNK1G20.57523027
103MAP3K20.57140167
104WNK10.56115603
105ERBB20.56105700
106RIPK40.54945703
107PTK60.52531865
108FYN0.51973646
109RAF10.51959653
110RPS6KA30.51712497
111CAMK10.51641604
112CDC42BPA0.50598858
113DMPK0.49360867
114CAMK2G0.49262486
115CDK190.48381681
116PDGFRB0.46642817
117ERBB30.46049444
118WEE10.45224669
119BCR0.44936676
120STK240.44480296
121GSK3A0.44217410
122MARK20.43920636
123FRK0.43684441
124SRC0.43595529
125PKN10.42090619
126CDK30.40948723
127IRAK10.40800213
128STK110.40067952
129CAMK2D0.40019791
130IRAK20.39921285
131PRKCH0.39825423
132ALK0.38896432
133YES10.38420538
134CDK80.37525605
135BCKDK0.36767734
136GRK70.36669994
137RPS6KA40.34405687
138PRKD10.32694028
139STK38L0.32300663
140TRIM280.32148531
141BRAF0.29624629
142PIM20.28968433
143PRKD20.28585617
144TAOK10.27378569
145RPS6KA50.26406791
146IKBKE0.26063367
147PRKCA0.25197511
148MAP2K60.24810968
149MET0.24389641
150PRKACA0.22926892
151PAK20.22095589
152CSNK1D0.21154404

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43639003
2Nitrogen metabolism_Homo sapiens_hsa009102.96298216
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.71971382
4Phototransduction_Homo sapiens_hsa047442.63177042
5Glutamatergic synapse_Homo sapiens_hsa047242.48747886
6GABAergic synapse_Homo sapiens_hsa047272.36288024
7Steroid biosynthesis_Homo sapiens_hsa001002.29886331
8Salivary secretion_Homo sapiens_hsa049702.22533756
9Long-term potentiation_Homo sapiens_hsa047202.16252269
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14430068
11Circadian entrainment_Homo sapiens_hsa047131.97746544
12Fatty acid biosynthesis_Homo sapiens_hsa000611.94207229
13Morphine addiction_Homo sapiens_hsa050321.91148654
14Long-term depression_Homo sapiens_hsa047301.84810314
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.83252152
16Gastric acid secretion_Homo sapiens_hsa049711.82302717
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75982788
18Synaptic vesicle cycle_Homo sapiens_hsa047211.75877709
19Amphetamine addiction_Homo sapiens_hsa050311.70287181
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69601886
21Oxidative phosphorylation_Homo sapiens_hsa001901.67885781
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64423546
23Taste transduction_Homo sapiens_hsa047421.62769170
24Olfactory transduction_Homo sapiens_hsa047401.62309547
25Parkinsons disease_Homo sapiens_hsa050121.60459599
26Insulin secretion_Homo sapiens_hsa049111.59045257
27Axon guidance_Homo sapiens_hsa043601.55170089
28Gap junction_Homo sapiens_hsa045401.52563274
29Dopaminergic synapse_Homo sapiens_hsa047281.48698748
30Renin secretion_Homo sapiens_hsa049241.48371164
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46680184
32Linoleic acid metabolism_Homo sapiens_hsa005911.46415653
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43212477
34Ether lipid metabolism_Homo sapiens_hsa005651.41057876
35Calcium signaling pathway_Homo sapiens_hsa040201.39886654
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38519479
37Dorso-ventral axis formation_Homo sapiens_hsa043201.37489918
38Protein export_Homo sapiens_hsa030601.32589677
39Cocaine addiction_Homo sapiens_hsa050301.31831521
40Cholinergic synapse_Homo sapiens_hsa047251.29198816
41Serotonergic synapse_Homo sapiens_hsa047261.28042007
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26693766
43Basal transcription factors_Homo sapiens_hsa030221.24910859
44Oxytocin signaling pathway_Homo sapiens_hsa049211.22082427
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21471994
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21117316
47Glioma_Homo sapiens_hsa052141.20378405
48cAMP signaling pathway_Homo sapiens_hsa040241.20353209
49* Melanogenesis_Homo sapiens_hsa049161.19080855
50GnRH signaling pathway_Homo sapiens_hsa049121.17347018
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17341519
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15766931
53* Basal cell carcinoma_Homo sapiens_hsa052171.13269410
54Alzheimers disease_Homo sapiens_hsa050101.12102966
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09793285
56ErbB signaling pathway_Homo sapiens_hsa040121.04749365
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04141316
58Primary immunodeficiency_Homo sapiens_hsa053401.03967131
59Dilated cardiomyopathy_Homo sapiens_hsa054141.02236974
60Estrogen signaling pathway_Homo sapiens_hsa049151.00110203
61Pancreatic secretion_Homo sapiens_hsa049720.98955535
62Bile secretion_Homo sapiens_hsa049760.95305535
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.94942648
64* Hedgehog signaling pathway_Homo sapiens_hsa043400.93578216
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93142360
66Cardiac muscle contraction_Homo sapiens_hsa042600.92859493
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91223482
68Thyroid hormone synthesis_Homo sapiens_hsa049180.87939959
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87246783
70* Hippo signaling pathway_Homo sapiens_hsa043900.86335767
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85746549
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85311382
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85098228
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83568364
75Butanoate metabolism_Homo sapiens_hsa006500.82649537
76Huntingtons disease_Homo sapiens_hsa050160.82500095
77Mineral absorption_Homo sapiens_hsa049780.79129394
78Choline metabolism in cancer_Homo sapiens_hsa052310.78477225
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77519545
80* Wnt signaling pathway_Homo sapiens_hsa043100.76117152
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73774082
82Regulation of autophagy_Homo sapiens_hsa041400.73389105
83Caffeine metabolism_Homo sapiens_hsa002320.73146703
84Rap1 signaling pathway_Homo sapiens_hsa040150.71900126
85Tight junction_Homo sapiens_hsa045300.68886356
86Type II diabetes mellitus_Homo sapiens_hsa049300.68152766
87T cell receptor signaling pathway_Homo sapiens_hsa046600.68037510
88Melanoma_Homo sapiens_hsa052180.63976650
89Notch signaling pathway_Homo sapiens_hsa043300.63692952
90Alcoholism_Homo sapiens_hsa050340.62965134
91Renal cell carcinoma_Homo sapiens_hsa052110.62822399
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62090247
93Endometrial cancer_Homo sapiens_hsa052130.61180573
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59979590
95MAPK signaling pathway_Homo sapiens_hsa040100.59896634
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59871754
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.58187977
98* Proteoglycans in cancer_Homo sapiens_hsa052050.58104143
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57955958
100Fatty acid metabolism_Homo sapiens_hsa012120.56667337
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56632511
102Circadian rhythm_Homo sapiens_hsa047100.55328109
103Ovarian steroidogenesis_Homo sapiens_hsa049130.54939593
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52813191
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52739884
106* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52639737
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.51989391
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51799470
109VEGF signaling pathway_Homo sapiens_hsa043700.51229618
110Ras signaling pathway_Homo sapiens_hsa040140.50947214
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50539506
112Bladder cancer_Homo sapiens_hsa052190.48095734
113Colorectal cancer_Homo sapiens_hsa052100.47615848
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47360513
115Collecting duct acid secretion_Homo sapiens_hsa049660.47338763
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.46852095
117Prion diseases_Homo sapiens_hsa050200.46066809
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.45730611
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45065177
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44782414
121Oocyte meiosis_Homo sapiens_hsa041140.44566699
122Vibrio cholerae infection_Homo sapiens_hsa051100.43674313
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43182161
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43162223
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.43061235
126Inositol phosphate metabolism_Homo sapiens_hsa005620.42965021
127Glucagon signaling pathway_Homo sapiens_hsa049220.42849353
128ECM-receptor interaction_Homo sapiens_hsa045120.42554626
129Focal adhesion_Homo sapiens_hsa045100.41770748
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41667599
131Glycerolipid metabolism_Homo sapiens_hsa005610.31167841
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.24128517

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