WNT7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glial cell proliferation (GO:0014009)5.63961178
2layer formation in cerebral cortex (GO:0021819)5.51974884
3* lens fiber cell development (GO:0070307)5.50719059
4central nervous system myelination (GO:0022010)4.80389266
5axon ensheathment in central nervous system (GO:0032291)4.80389266
6nonmotile primary cilium assembly (GO:0035058)4.61867860
7positive regulation of synapse maturation (GO:0090129)4.36139364
8hemidesmosome assembly (GO:0031581)4.26358643
9viral transcription (GO:0019083)4.18361821
10locomotory exploration behavior (GO:0035641)4.16067125
11behavioral response to nicotine (GO:0035095)4.13152320
12ribosomal small subunit biogenesis (GO:0042274)4.12310684
13translational termination (GO:0006415)4.03357484
14regulation of hippo signaling (GO:0035330)3.98478410
15cell proliferation in forebrain (GO:0021846)3.94285450
16proline biosynthetic process (GO:0006561)3.91574521
17base-excision repair, AP site formation (GO:0006285)3.87703154
18maturation of SSU-rRNA (GO:0030490)3.86696448
19interferon-gamma secretion (GO:0072643)3.79230250
20body morphogenesis (GO:0010171)3.78618966
21embryonic body morphogenesis (GO:0010172)3.76121598
22tongue development (GO:0043586)3.70005057
23pattern specification involved in kidney development (GO:0061004)3.64854857
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.63667339
25dendritic spine morphogenesis (GO:0060997)3.63504571
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57724162
27negative regulation of oligodendrocyte differentiation (GO:0048715)3.57369133
28synaptic vesicle maturation (GO:0016188)3.55042897
29* lung epithelium development (GO:0060428)3.43953621
30branching involved in salivary gland morphogenesis (GO:0060445)3.38099354
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37363751
32negative regulation of astrocyte differentiation (GO:0048712)3.36391955
33translational elongation (GO:0006414)3.34551800
34lens morphogenesis in camera-type eye (GO:0002089)3.30463788
35viral life cycle (GO:0019058)3.27926549
36L-serine transport (GO:0015825)3.27706185
37glutamate secretion (GO:0014047)3.24977400
38sodium ion export (GO:0071436)3.24659569
39epithelial cell differentiation involved in prostate gland development (GO:0060742)3.24204292
40exploration behavior (GO:0035640)3.23239819
41central nervous system projection neuron axonogenesis (GO:0021952)3.22022529
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17765814
43ephrin receptor signaling pathway (GO:0048013)3.17687994
44cerebral cortex neuron differentiation (GO:0021895)3.17227386
45cell communication by electrical coupling (GO:0010644)3.17214364
46vocalization behavior (GO:0071625)3.16778218
47protein targeting to ER (GO:0045047)3.16142499
48renal system development (GO:0072001)3.14828517
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14221514
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13936922
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12199647
52cochlea development (GO:0090102)3.12098711
53negative regulation of cell fate commitment (GO:0010454)3.11083224
54cellular protein complex disassembly (GO:0043624)3.10847397
55embryonic foregut morphogenesis (GO:0048617)3.10022981
56hippo signaling (GO:0035329)3.09950037
57dendrite morphogenesis (GO:0048813)3.08850843
58synaptic vesicle exocytosis (GO:0016079)3.08056821
59regulation of glomerular filtration (GO:0003093)3.07839530
60cotranslational protein targeting to membrane (GO:0006613)3.07606872
61positive regulation of triglyceride biosynthetic process (GO:0010867)3.06867437
62camera-type eye morphogenesis (GO:0048593)3.06272120
63axonemal dynein complex assembly (GO:0070286)3.03757223
64axonal fasciculation (GO:0007413)3.03195933
65proline metabolic process (GO:0006560)3.02686359
66motile cilium assembly (GO:0044458)3.02279757
67polyketide metabolic process (GO:0030638)3.00376363
68doxorubicin metabolic process (GO:0044598)3.00376363
69daunorubicin metabolic process (GO:0044597)3.00376363
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98828430
71clathrin coat assembly (GO:0048268)2.97514903
72negative regulation of sodium ion transport (GO:0010766)2.96867301
73head development (GO:0060322)2.95945368
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94942459
75negative regulation of glial cell differentiation (GO:0045686)2.94859717
76alanine transport (GO:0032328)2.94497022
77positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93950285
78startle response (GO:0001964)2.93620076
79regulation of astrocyte differentiation (GO:0048710)2.93178956
80protein localization to endoplasmic reticulum (GO:0070972)2.92695657
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92298168
82cornea development in camera-type eye (GO:0061303)2.92090662
83mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.90809502
84myoblast fusion (GO:0007520)2.89923813
85primary alcohol catabolic process (GO:0034310)2.89686770
86postsynaptic membrane organization (GO:0001941)2.89606655
87chondrocyte proliferation (GO:0035988)2.89026545
88axon extension involved in axon guidance (GO:0048846)2.88867638
89neuron projection extension involved in neuron projection guidance (GO:1902284)2.88867638
90axon extension (GO:0048675)2.88855082
91cellular potassium ion homeostasis (GO:0030007)2.87532428
92regulation of synapse maturation (GO:0090128)2.86027031
93pyrimidine nucleobase catabolic process (GO:0006208)2.86006473
94regulation of glutamate receptor signaling pathway (GO:1900449)2.85968789
95epithelial cell fate commitment (GO:0072148)2.85683723
96ribosomal small subunit assembly (GO:0000028)2.85149146
97proline transport (GO:0015824)2.84954947
98regulation of synapse structural plasticity (GO:0051823)2.84480554
99retinal ganglion cell axon guidance (GO:0031290)2.83544457
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.83447957
101establishment of nucleus localization (GO:0040023)2.83127196
102mesodermal cell differentiation (GO:0048333)2.82450024
103inner ear morphogenesis (GO:0042472)2.81869273
104negative regulation of catenin import into nucleus (GO:0035414)2.80717766
105negative regulation of axon extension involved in axon guidance (GO:0048843)2.80042964
106protein localization to synapse (GO:0035418)2.78996541
107regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78963507
108cell adhesion mediated by integrin (GO:0033627)2.78140825
109auditory receptor cell differentiation (GO:0042491)2.78051155
110neuronal stem cell maintenance (GO:0097150)2.77890488
111regulation of neuronal synaptic plasticity (GO:0048168)2.77874071
112cell migration in hindbrain (GO:0021535)2.77687038
113protein complex disassembly (GO:0043241)2.77391327
114skeletal muscle organ development (GO:0060538)2.76862683
115dendritic spine organization (GO:0097061)2.74766837
116* collecting duct development (GO:0072044)2.73738669
117positive regulation of pseudopodium assembly (GO:0031274)2.73407471
118positive regulation of axon extension (GO:0045773)2.72049794
119substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.71424435
120substrate-independent telencephalic tangential migration (GO:0021826)2.71424435
121neuron projection extension (GO:1990138)2.71126595
122serine transport (GO:0032329)2.71122073
123positive regulation of cell fate commitment (GO:0010455)2.70459654
124midbrain development (GO:0030901)2.69963197
125ear development (GO:0043583)2.69207404
126DNA ligation (GO:0006266)2.67938566
127aminoglycoside antibiotic metabolic process (GO:0030647)2.66717374
128neuron recognition (GO:0008038)2.66035686
129neural tube development (GO:0021915)2.65360198
130establishment of monopolar cell polarity (GO:0061162)2.64337366
131establishment or maintenance of monopolar cell polarity (GO:0061339)2.64337366
132regulation of axon extension involved in axon guidance (GO:0048841)2.64065866
133spinal cord development (GO:0021510)2.63702074
134cell-cell junction maintenance (GO:0045217)2.62775358
135innervation (GO:0060384)2.62631128
136cerebellar granule cell differentiation (GO:0021707)2.60862588
137ectoderm development (GO:0007398)2.60771027
138renal system process involved in regulation of blood volume (GO:0001977)2.60757738
139regulation of dendritic spine morphogenesis (GO:0061001)2.60379036
140negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.59888610
141neuroblast proliferation (GO:0007405)2.59776037
142macromolecular complex disassembly (GO:0032984)2.59100285
143neurotransmitter-gated ion channel clustering (GO:0072578)2.58973854
144cellular response to cholesterol (GO:0071397)2.58158936
145positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.58040418
146neuron cell-cell adhesion (GO:0007158)2.56712100
147lateral sprouting from an epithelium (GO:0060601)2.56210734
148establishment of tissue polarity (GO:0007164)2.56099310
149establishment of planar polarity (GO:0001736)2.56099310
150desmosome organization (GO:0002934)2.55953678
151syncytium formation by plasma membrane fusion (GO:0000768)2.55730981
152dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55531062
153limb bud formation (GO:0060174)2.55244233
154regulation of phospholipid biosynthetic process (GO:0071071)2.55143933
155positive regulation of gastrulation (GO:2000543)2.54212255
156regulation of water loss via skin (GO:0033561)2.53699407
157translational initiation (GO:0006413)2.53535382
158nephron tubule formation (GO:0072079)2.52414883
159positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52139558
160response to auditory stimulus (GO:0010996)2.51986473
161hair follicle development (GO:0001942)2.51472490
162negative regulation of axon guidance (GO:1902668)2.50475970
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50392560
164auditory behavior (GO:0031223)2.50154484
165negative regulation of microtubule polymerization (GO:0031115)2.49218689
166anatomical structure maturation (GO:0071695)2.48726259
167positive regulation of astrocyte differentiation (GO:0048711)2.47772575
168regulation of axon extension (GO:0030516)2.45882883
169pyrimidine nucleotide catabolic process (GO:0006244)2.45474191
170semaphorin-plexin signaling pathway (GO:0071526)2.43451956
171positive regulation of action potential (GO:0045760)2.42351680
172negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.41046663
173establishment of apical/basal cell polarity (GO:0035089)2.40787351
174protein targeting to membrane (GO:0006612)2.40779431
175regulation of mesoderm development (GO:2000380)2.40200634
176chromatin assembly (GO:0031497)2.38524974
177neuron fate determination (GO:0048664)2.36909140
178regulation of endothelial cell chemotaxis (GO:2001026)2.34825541
179positive regulation of histone deacetylation (GO:0031065)2.34622252
180white fat cell differentiation (GO:0050872)2.33653283
181dorsal/ventral pattern formation (GO:0009953)2.33199219
182left/right pattern formation (GO:0060972)2.32628981
183dorsal/ventral neural tube patterning (GO:0021904)2.31160663
184intraciliary transport (GO:0042073)2.30250517
185aldehyde catabolic process (GO:0046185)2.29742512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.89038059
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50973547
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.29351359
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.91040291
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56595814
6ZNF263_19887448_ChIP-Seq_K562_Human2.35642339
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22878392
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17669145
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12915885
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12915885
11EZH2_22144423_ChIP-Seq_EOC_Human2.08224284
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07516881
13* ESR2_21235772_ChIP-Seq_MCF-7_Human2.07072140
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.05703017
15* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04247523
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02980604
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.02665931
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02595519
19* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01152070
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99174876
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98432355
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97117357
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92136260
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.88701799
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87792569
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.86525091
27* EZH2_27304074_Chip-Seq_ESCs_Mouse1.81003871
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78351908
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76864546
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.76861056
31P68_20966046_ChIP-Seq_HELA_Human1.76400918
32* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75436390
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73486109
34* TP53_20018659_ChIP-ChIP_R1E_Mouse1.73109966
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72827639
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70196249
37* KDM2B_26808549_Chip-Seq_K562_Human1.67376304
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63614663
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.63219835
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.57228647
41SMC4_20622854_ChIP-Seq_HELA_Human1.54636623
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53927845
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53415893
44* DROSHA_22980978_ChIP-Seq_HELA_Human1.51060145
45* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49667567
46* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49616834
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49237214
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.47094263
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46862458
50* TET1_21451524_ChIP-Seq_MESCs_Mouse1.45677831
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44823036
52AR_21572438_ChIP-Seq_LNCaP_Human1.42039458
53* RING1B_27294783_Chip-Seq_NPCs_Mouse1.41067227
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40815522
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39398615
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39134214
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38819409
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37902697
59* CBX2_27304074_Chip-Seq_ESCs_Mouse1.37468845
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36589115
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.35346910
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.35025218
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33614839
64* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30191305
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29679645
66* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29170711
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.26956036
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26794892
69* REST_21632747_ChIP-Seq_MESCs_Mouse1.26075606
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.25191954
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25046443
72* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24956937
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24395694
74* LXR_22292898_ChIP-Seq_THP-1_Human1.22385430
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21979015
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.21911620
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21621937
78RACK7_27058665_Chip-Seq_MCF-7_Human1.21530695
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19796941
80KLF5_25053715_ChIP-Seq_YYC3_Human1.19347655
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19087055
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18969330
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17332402
84ZNF274_21170338_ChIP-Seq_K562_Hela1.17011586
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16629814
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15262037
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14647028
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13954905
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13867565
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13867565
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.12266518
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11875445
93AHR_22903824_ChIP-Seq_MCF-7_Human1.11839020
94* TP63_22573176_ChIP-Seq_HFKS_Human1.10558815
95* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09581570
96ATF3_27146783_Chip-Seq_COLON_Human1.08844420
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08536299
98RARA_24833708_ChIP-Seq_LIVER_Mouse1.07863795
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07538472
100TP53_22127205_ChIP-Seq_IMR90_Human1.06688407
101E2F1_20622854_ChIP-Seq_HELA_Human1.06627439
102* REST_18959480_ChIP-ChIP_MESCs_Mouse1.06386650
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05447777
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05175791
105* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05092117
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04098333
107* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03617765
108XRN2_22483619_ChIP-Seq_HELA_Human1.02958303
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02468108
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00993075
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00976363
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00462494
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.98318566
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98050029
115* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97209064
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96835366
117SA1_27219007_Chip-Seq_Bcells_Human0.96698871
118* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96110649
119FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95692794
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95401087
121OCT4_19829295_ChIP-Seq_ESCs_Human0.95232926
122BCL6_27268052_Chip-Seq_Bcells_Human0.95113216
123TP53_18474530_ChIP-ChIP_U2OS_Human0.94782249
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.94394135
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.94362297
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93894845
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93459359
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.93361279
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92047327
130* KDM2B_26808549_Chip-Seq_JURKAT_Human0.91970348
131CTCF_20526341_ChIP-Seq_ESCs_Human0.91420047
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90783085
133HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90430252
134RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90375017
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90170243
136CTCF_27219007_Chip-Seq_Bcells_Human0.89875646
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88730311
138CREB1_26743006_Chip-Seq_LNCaP_Human0.87933479
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87710820
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87682199
141* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87171630
142JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87161916
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87005783
144RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86942824
145RARB_24833708_ChIP-Seq_LIVER_Mouse0.85166860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.12338794
2MP0010234_abnormal_vibrissa_follicle4.38711914
3MP0004859_abnormal_synaptic_plasticity4.04715921
4MP0000537_abnormal_urethra_morphology3.94319201
5MP0009780_abnormal_chondrocyte_physiolo3.92553185
6MP0005646_abnormal_pituitary_gland3.48644193
7MP0000566_synostosis3.44753901
8MP0006292_abnormal_olfactory_placode2.88604517
9MP0003880_abnormal_central_pattern2.72664463
10MP0003329_amyloid_beta_deposits2.65642636
11MP0004858_abnormal_nervous_system2.54509486
12MP0010030_abnormal_orbit_morphology2.47820664
13MP0005423_abnormal_somatic_nervous2.34527731
14MP0002796_impaired_skin_barrier2.32776134
15MP0002102_abnormal_ear_morphology2.30880799
16MP0000778_abnormal_nervous_system2.26529376
17MP0004270_analgesia2.09091560
18MP0003941_abnormal_skin_development2.08589511
19MP0010678_abnormal_skin_adnexa2.04972700
20MP0003635_abnormal_synaptic_transmissio2.04193870
21MP0008057_abnormal_DNA_replication1.99191559
22MP0002234_abnormal_pharynx_morphology1.95345443
23MP0005623_abnormal_meninges_morphology1.77596320
24MP0009278_abnormal_bone_marrow1.76620443
25MP0002063_abnormal_learning/memory/cond1.75697238
26MP0004885_abnormal_endolymph1.74741209
27MP0003705_abnormal_hypodermis_morpholog1.73644410
28MP0009053_abnormal_anal_canal1.65965811
29MP0002697_abnormal_eye_size1.65208100
30MP0003119_abnormal_digestive_system1.54568743
31MP0000647_abnormal_sebaceous_gland1.54104465
32MP0002089_abnormal_postnatal_growth/wei1.52376516
33MP0001293_anophthalmia1.49388028
34MP0002254_reproductive_system_inflammat1.47792387
35MP0002653_abnormal_ependyma_morphology1.45880335
36MP0000762_abnormal_tongue_morphology1.38974261
37MP0001299_abnormal_eye_distance/1.37991455
38MP0000383_abnormal_hair_follicle1.36745621
39MP0003283_abnormal_digestive_organ1.36537964
40MP0000026_abnormal_inner_ear1.36161645
41MP0000534_abnormal_ureter_morphology1.35910743
42MP0005501_abnormal_skin_physiology1.35799800
43MP0003123_paternal_imprinting1.35469985
44MP0000579_abnormal_nail_morphology1.35337155
45MP0010352_gastrointestinal_tract_polyps1.35057488
46* MP0003115_abnormal_respiratory_system1.33795769
47MP0005187_abnormal_penis_morphology1.32091024
48MP0002184_abnormal_innervation1.30207319
49MP0000467_abnormal_esophagus_morphology1.29813386
50MP0002938_white_spotting1.29097645
51MP0003136_yellow_coat_color1.26665949
52MP0000955_abnormal_spinal_cord1.26068214
53MP0008875_abnormal_xenobiotic_pharmacok1.25395709
54MP0002909_abnormal_adrenal_gland1.21242402
55MP0003632_abnormal_nervous_system1.21151307
56MP0003861_abnormal_nervous_system1.20481210
57MP0005197_abnormal_uvea_morphology1.19013945
58MP0001849_ear_inflammation1.17886846
59MP0005248_abnormal_Harderian_gland1.17268690
60MP0002092_abnormal_eye_morphology1.16659504
61MP0002163_abnormal_gland_morphology1.16086892
62MP0000428_abnormal_craniofacial_morphol1.16084688
63MP0009840_abnormal_foam_cell1.14547940
64MP0004133_heterotaxia1.11837345
65MP0002733_abnormal_thermal_nociception1.10941767
66MP0005193_abnormal_anterior_eye1.10066789
67MP0002249_abnormal_larynx_morphology1.09302095
68MP0002152_abnormal_brain_morphology1.09298566
69MP0003634_abnormal_glial_cell1.09122634
70MP0009745_abnormal_behavioral_response1.08632940
71MP0001346_abnormal_lacrimal_gland1.07698640
72MP0003937_abnormal_limbs/digits/tail_de1.07424846
73MP0003942_abnormal_urinary_system1.07412819
74MP0002572_abnormal_emotion/affect_behav1.06413788
75MP0002064_seizures1.06161051
76MP0004272_abnormal_basement_membrane1.05643127
77MP0003566_abnormal_cell_adhesion1.04250986
78MP0002282_abnormal_trachea_morphology1.04072600
79MP0004811_abnormal_neuron_physiology1.02796354
80MP0000049_abnormal_middle_ear1.02086072
81MP0001440_abnormal_grooming_behavior1.00951366
82MP0005076_abnormal_cell_differentiation1.00842798
83MP0002734_abnormal_mechanical_nocicepti1.00650238
84MP0003938_abnormal_ear_development0.99236631
85* MP0005195_abnormal_posterior_eye0.98310291
86MP0003755_abnormal_palate_morphology0.98076843
87MP0001958_emphysema0.96391146
88MP0003878_abnormal_ear_physiology0.95528258
89MP0005377_hearing/vestibular/ear_phenot0.95528258
90MP0000427_abnormal_hair_cycle0.94827137
91MP0000678_abnormal_parathyroid_gland0.94611427
92MP0002882_abnormal_neuron_morphology0.94156794
93MP0002557_abnormal_social/conspecific_i0.93885023
94MP0000631_abnormal_neuroendocrine_gland0.93285693
95MP0001486_abnormal_startle_reflex0.93071905
96MP0009384_cardiac_valve_regurgitation0.92731462
97MP0005083_abnormal_biliary_tract0.92406890
98MP0001216_abnormal_epidermal_layer0.91514200
99MP0000604_amyloidosis0.91452305
100MP0002233_abnormal_nose_morphology0.91393075
101MP0000462_abnormal_digestive_system0.91145121
102MP0010771_integument_phenotype0.88163490
103MP0003091_abnormal_cell_migration0.88069106
104MP0003453_abnormal_keratinocyte_physiol0.87989261
105MP0002752_abnormal_somatic_nervous0.85014645
106MP0001502_abnormal_circadian_rhythm0.82919084
107MP0004233_abnormal_muscle_weight0.82209789
108MP0008569_lethality_at_weaning0.81484557
109MP0003936_abnormal_reproductive_system0.81388780
110MP0005167_abnormal_blood-brain_barrier0.81180998
111MP0000377_abnormal_hair_follicle0.79905301
112* MP0001286_abnormal_eye_development0.79578132
113MP0002084_abnormal_developmental_patter0.79016013
114MP0005391_vision/eye_phenotype0.78283161
115MP0003693_abnormal_embryo_hatching0.78139554
116MP0005670_abnormal_white_adipose0.77683914
117MP0001188_hyperpigmentation0.77071146
118MP0002090_abnormal_vision0.75884174
119MP0001177_atelectasis0.75016096
120MP0001348_abnormal_lacrimal_gland0.74818839
121MP0002098_abnormal_vibrissa_morphology0.74231721
122MP0002928_abnormal_bile_duct0.72191979
123MP0001663_abnormal_digestive_system0.70865787
124MP0003787_abnormal_imprinting0.69358675
125MP0001340_abnormal_eyelid_morphology0.68725992
126MP0005394_taste/olfaction_phenotype0.68679347
127MP0005499_abnormal_olfactory_system0.68679347
128MP0002210_abnormal_sex_determination0.68392940
129MP0001970_abnormal_pain_threshold0.68077971
130MP0001485_abnormal_pinna_reflex0.67746729
131* MP0002081_perinatal_lethality0.67362836
132MP0000163_abnormal_cartilage_morphology0.66596456
133MP0002177_abnormal_outer_ear0.65959332
134MP0002116_abnormal_craniofacial_bone0.65877944
135MP0000750_abnormal_muscle_regeneration0.64515409
136MP0008789_abnormal_olfactory_epithelium0.64325055
137MP0002111_abnormal_tail_morphology0.63850694
138MP0002751_abnormal_autonomic_nervous0.63519332
139MP0002095_abnormal_skin_pigmentation0.62619130
140MP0005409_darkened_coat_color0.59277955
141MP0005381_digestive/alimentary_phenotyp0.57986291
142MP0000432_abnormal_head_morphology0.57064114
143MP0008872_abnormal_physiological_respon0.56627813
144MP0003315_abnormal_perineum_morphology0.55249473
145MP0008775_abnormal_heart_ventricle0.55074456

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)5.64382516
2Nuclear cataract (HP:0100018)5.00657680
3Aplasia involving bones of the extremities (HP:0009825)4.87033896
4Aplasia involving bones of the upper limbs (HP:0009823)4.87033896
5Aplasia of the phalanges of the hand (HP:0009802)4.87033896
6True hermaphroditism (HP:0010459)4.28763267
7Zonular cataract (HP:0010920)4.14834563
8Aplasia/Hypoplasia of the sacrum (HP:0008517)4.01137299
9Decreased central vision (HP:0007663)3.95605450
10Dyschromatopsia (HP:0007641)3.61687337
11Onycholysis (HP:0001806)3.59838780
12Fragile nails (HP:0001808)3.32746500
13Pendular nystagmus (HP:0012043)3.30413799
14Coronal craniosynostosis (HP:0004440)3.27974379
15Anophthalmia (HP:0000528)3.15261662
16Bronchomalacia (HP:0002780)3.11769048
17Pancreatic fibrosis (HP:0100732)3.09111524
18Cerebral inclusion bodies (HP:0100314)3.05679362
19Milia (HP:0001056)3.00061428
20Nephronophthisis (HP:0000090)2.98882118
21Cystic liver disease (HP:0006706)2.91491550
22Sex reversal (HP:0012245)2.89216731
23Abnormal sex determination (HP:0012244)2.89216731
24Abnormality of cells of the erythroid lineage (HP:0012130)2.86088144
25Neurofibrillary tangles (HP:0002185)2.78377274
26Rib fusion (HP:0000902)2.75586703
27Ankyloglossia (HP:0010296)2.71165070
28Myokymia (HP:0002411)2.70705335
29Split foot (HP:0001839)2.69651998
30High anterior hairline (HP:0009890)2.64114825
31Tubular atrophy (HP:0000092)2.59925663
32Abnormality of the renal medulla (HP:0100957)2.59519066
33Humeroradial synostosis (HP:0003041)2.54867018
34Synostosis involving the elbow (HP:0003938)2.54867018
35Molar tooth sign on MRI (HP:0002419)2.54537727
36Abnormality of midbrain morphology (HP:0002418)2.54537727
37Neonatal short-limb short stature (HP:0008921)2.54159740
38Neoplasm of the adrenal cortex (HP:0100641)2.54025174
39Anencephaly (HP:0002323)2.52792634
40Sclerocornea (HP:0000647)2.52192264
41Fibular aplasia (HP:0002990)2.51437407
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.49829552
43Absent/shortened dynein arms (HP:0200106)2.49829552
44Abnormality of cochlea (HP:0000375)2.45702072
45Pancreatic cysts (HP:0001737)2.44620698
46Germ cell neoplasia (HP:0100728)2.44475727
47Abnormality of the middle phalanges of the toes (HP:0010183)2.44251555
48Cerebellar dysplasia (HP:0007033)2.41658099
49Type II lissencephaly (HP:0007260)2.39815642
50Maternal diabetes (HP:0009800)2.38258782
51Mixed hearing impairment (HP:0000410)2.37532205
5211 pairs of ribs (HP:0000878)2.36478245
53Shallow orbits (HP:0000586)2.34844197
54Atrophic scars (HP:0001075)2.34442034
55Micronodular cirrhosis (HP:0001413)2.32538235
56Abnormal respiratory epithelium morphology (HP:0012253)2.30018990
57Abnormal respiratory motile cilium morphology (HP:0005938)2.30018990
58Holoprosencephaly (HP:0001360)2.28438486
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.27551226
60Amblyopia (HP:0000646)2.27408687
61Esophageal atresia (HP:0002032)2.27252373
62Reticulocytopenia (HP:0001896)2.23768486
63Alacrima (HP:0000522)2.22382261
64Severe visual impairment (HP:0001141)2.21882297
65Abnormality of oral frenula (HP:0000190)2.20731209
66Amelogenesis imperfecta (HP:0000705)2.18282792
67Apathy (HP:0000741)2.17484937
68Absent thumb (HP:0009777)2.15009990
69Arnold-Chiari malformation (HP:0002308)2.09376221
70Abnormal number of erythroid precursors (HP:0012131)2.09343419
71Visual hallucinations (HP:0002367)2.08940882
72Postaxial foot polydactyly (HP:0001830)2.08940131
73Diminished motivation (HP:0000745)2.08666010
74Trigonocephaly (HP:0000243)2.08398981
75Nail dystrophy (HP:0008404)2.07642239
76Conical tooth (HP:0000698)2.05308398
77Elfin facies (HP:0004428)2.03199480
78Hypoplastic nipples (HP:0002557)2.00985267
79Focal segmental glomerulosclerosis (HP:0000097)2.00222872
80Abnormal ciliary motility (HP:0012262)1.99391069
81Athetosis (HP:0002305)1.99278354
82Plantar hyperkeratosis (HP:0007556)1.98979156
83Arterial tortuosity (HP:0005116)1.97248092
84Supranuclear gaze palsy (HP:0000605)1.97012782
85Chronic bronchitis (HP:0004469)1.96551148
86Mutism (HP:0002300)1.96093396
87Annular pancreas (HP:0001734)1.93991173
88Adrenal hypoplasia (HP:0000835)1.93909239
89Obstructive sleep apnea (HP:0002870)1.92075045
90Amyotrophic lateral sclerosis (HP:0007354)1.91997777
91Renal salt wasting (HP:0000127)1.90213034
92Abnormal respiratory motile cilium physiology (HP:0012261)1.89943232
93Male pseudohermaphroditism (HP:0000037)1.89787330
94Thickened helices (HP:0000391)1.89140105
95Renal dysplasia (HP:0000110)1.88839291
96Partial duplication of thumb phalanx (HP:0009944)1.88443440
97Morphological abnormality of the inner ear (HP:0011390)1.88360682
98Adactyly (HP:0009776)1.88241514
99Back pain (HP:0003418)1.88037280
100Ankle clonus (HP:0011448)1.86340140
101Absent epiphyses (HP:0010577)1.84886832
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84886832
103Preaxial hand polydactyly (HP:0001177)1.84487704
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84343739
105Abnormality of the aortic arch (HP:0012303)1.83282712
106Meningocele (HP:0002435)1.83257891
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82682430
108Oligodactyly (hands) (HP:0001180)1.78777220
109Myelomeningocele (HP:0002475)1.78156346
110Furrowed tongue (HP:0000221)1.77359366
111Choanal stenosis (HP:0000452)1.76803813
112Aplasia/Hypoplasia of the spleen (HP:0010451)1.75162715
113Hypoplasia of dental enamel (HP:0006297)1.73691490
114Hypokinesia (HP:0002375)1.73679582
115Concave nail (HP:0001598)1.73528836
116Abnormality of the diencephalon (HP:0010662)1.71741084
117Leiomyosarcoma (HP:0100243)1.71730983
118Uterine leiomyosarcoma (HP:0002891)1.71730983
119Oligodactyly (HP:0012165)1.71179808
120Anterior segment dysgenesis (HP:0007700)1.70712157
121Glomerulosclerosis (HP:0000096)1.70494800
122Abnormal number of incisors (HP:0011064)1.70272056
123Intellectual disability, profound (HP:0002187)1.70074173
124Insomnia (HP:0100785)1.69959606
125Clumsiness (HP:0002312)1.69041196
126Abnormality of the antihelix (HP:0009738)1.68901500
127Ectopic kidney (HP:0000086)1.68315800
128Partial duplication of the phalanx of hand (HP:0009999)1.68235425
129Curly hair (HP:0002212)1.67664308
130Pointed chin (HP:0000307)1.66819100
131Fibular hypoplasia (HP:0003038)1.66624590
132Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66454798
133Taurodontia (HP:0000679)1.64718664
134Abnormality of permanent molar morphology (HP:0011071)1.64718664
135Abnormality of the dental root (HP:0006486)1.64718664
136Vascular tortuosity (HP:0004948)1.64469780
137Septo-optic dysplasia (HP:0100842)1.64225625
138Heterotopia (HP:0002282)1.63987455
139Hemiparesis (HP:0001269)1.63335049
140Scrotal hypoplasia (HP:0000046)1.62720844
141Vitreoretinal degeneration (HP:0000655)1.62421872
142Abnormality of the 4th metacarpal (HP:0010012)1.62168682
143Pili torti (HP:0003777)1.62146874
144Depressed nasal ridge (HP:0000457)1.62065825
145Abnormal rod and cone electroretinograms (HP:0008323)1.61601131
146Right ventricular cardiomyopathy (HP:0011663)1.61536416
147Hemiplegia (HP:0002301)1.60820092
148Macrocytic anemia (HP:0001972)1.60609247
149Pterygium (HP:0001059)1.60163609
150Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.59971303
151Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59601255
152Hyperthyroidism (HP:0000836)1.58432446
153Hallux valgus (HP:0001822)1.58352259
154Congenital hepatic fibrosis (HP:0002612)1.58194876
155Xerostomia (HP:0000217)1.57958997
156Deviation of the hallux (HP:0010051)1.57751459
157Turricephaly (HP:0000262)1.57380388
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.56721755
159Hypotrichosis (HP:0001006)1.55954945
160Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55749587
161Missing ribs (HP:0000921)1.55481959
162Atresia of the external auditory canal (HP:0000413)1.55405968
163Decreased lacrimation (HP:0000633)1.54285012
164Polycystic kidney dysplasia (HP:0000113)1.54171474
165Choroideremia (HP:0001139)1.54155433
166Abnormality of the dental pulp (HP:0006479)1.53931494
167Hypoplasia of the uterus (HP:0000013)1.53783440
168Lissencephaly (HP:0001339)1.53674652
169Medial flaring of the eyebrow (HP:0010747)1.53608555
170Tubulointerstitial fibrosis (HP:0005576)1.53185938
171Hypoplasia of the radius (HP:0002984)1.52924885
172Aplasia/Hypoplasia of the clavicles (HP:0006710)1.52436645
173Broad distal phalanx of finger (HP:0009836)1.52378636
174Increased corneal curvature (HP:0100692)1.51951687
175Keratoconus (HP:0000563)1.51951687
176Selective tooth agenesis (HP:0001592)1.51854348
177Abnormality of binocular vision (HP:0011514)1.51268909
178Diplopia (HP:0000651)1.51268909
179Tarsal synostosis (HP:0008368)1.49748270
180Malignant gastrointestinal tract tumors (HP:0006749)1.49716682
181Gastrointestinal carcinoma (HP:0002672)1.49716682
182Abnormality of the lacrimal duct (HP:0011481)1.48562489
183Neonatal death (HP:0003811)1.48150623
184Nasolacrimal duct obstruction (HP:0000579)1.48028872
185Bladder carcinoma (HP:0002862)1.47721076
186Bladder neoplasm (HP:0009725)1.47721076
187Hyperacusis (HP:0010780)1.47550990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.83035047
2MARK14.38123379
3SIK13.57705348
4EPHA43.17820976
5MAP3K93.16467128
6LMTK22.31849791
7EPHB22.27994374
8LATS22.00787958
9PHKG22.00117167
10PHKG12.00117167
11TRIB31.91208590
12MAPK151.90754538
13PRKD21.85762524
14NTRK31.82653316
15KSR11.82161435
16WNK41.78635651
17MINK11.71574185
18TYRO31.71556562
19FER1.64835944
20CDC71.61948274
21IRAK31.58374507
22DDR21.58104334
23NTRK21.56868213
24SCYL21.55960946
25AURKB1.51836294
26NME21.51692712
27PRKD31.51131391
28PAK61.47676740
29CAMKK11.42277030
30PTK21.41560469
31PAK41.40588132
32DYRK1B1.38930062
33ERBB31.37985963
34RPS6KB21.37086978
35PAK31.34222402
36KSR21.32980167
37TESK11.26744035
38NTRK11.26053414
39BUB11.25088858
40MUSK1.24877672
41CASK1.24721512
42CAMK1D1.24627823
43TLK11.21736887
44CDK81.21546628
45MST41.19005608
46LIMK11.16577818
47MAP3K21.12312282
48FGFR11.10530402
49VRK21.09671535
50ICK1.08415048
51PRKCH1.08320413
52RIPK11.05537704
53PRKCI1.02293162
54DAPK21.00549949
55PKN20.98844720
56TAOK10.95691260
57DYRK20.95580843
58MAP3K120.95065844
59PDGFRA0.94770402
60STK380.93743375
61PTK60.92844782
62PLK20.92568272
63ROCK20.92214846
64LATS10.91754940
65NEK20.91509775
66MAPKAPK30.91436773
67MTOR0.91265968
68CDK50.90822783
69CAMK1G0.90771240
70ZAK0.89672767
71STK390.84362258
72MAP3K40.81853079
73AURKA0.80452074
74ILK0.80157704
75LRRK20.79994479
76TTN0.78362963
77CDK150.77746350
78CAMK2B0.77719943
79CDK180.77053517
80CDK140.76781227
81MARK20.76062182
82EPHB10.75546473
83MAP2K10.75313583
84MAP2K70.74145599
85BMX0.73901194
86CSNK1G20.69264240
87ROCK10.68310800
88CDK11A0.68198638
89ERBB20.68037663
90FGFR20.67909654
91MAP2K60.67904470
92MAPK130.67833360
93PRKCZ0.67629910
94NEK10.66341677
95FGR0.66026312
96MST1R0.65812518
97DMPK0.65781493
98ALK0.63055499
99NME10.62060129
100BCKDK0.60064490
101WNK10.59264073
102DAPK10.59027561
103MAP2K20.58621332
104MET0.58013427
105ATR0.57879540
106CAMK2D0.56649621
107MAP3K70.55546089
108FGFR30.54344587
109CHEK20.52194864
110GRK10.51504700
111ARAF0.51345019
112TTK0.51344222
113SMG10.51216315
114CDK10.49075724
115EIF2AK10.48609803
116BCR0.48223513
117STK110.47431030
118RPS6KA20.47224335
119CAMK2A0.46201775
120BRSK10.45625530
121RPS6KA60.44890289
122SGK10.44371357
123UHMK10.43060086
124DYRK1A0.42822278
125PRKCG0.42816070
126CAMKK20.41424306
127CAMK2G0.40289663
128EEF2K0.40034445
129HIPK20.39091379
130BRAF0.38202045
131AKT20.37828284
132PLK10.37542941
133CSNK1E0.37540053
134PRKCE0.36995772
135TAOK20.35536010
136CSNK1G30.35190356
137CDK70.35093198
138RPS6KL10.34613519
139RPS6KC10.34613519
140CHEK10.34599146
141WNK30.34559696
142RET0.33697273
143MAPK90.33591544
144CHUK0.33247145
145PNCK0.32916834
146TNIK0.31986277
147SRC0.31384015
148GRK50.31347669
149CSNK1A1L0.31098414
150CAMK10.31089371
151SIK20.30240959
152ERBB40.29679478

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.69931234
2Sulfur relay system_Homo sapiens_hsa041222.97673604
3Mismatch repair_Homo sapiens_hsa034302.95980429
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.87482263
5Base excision repair_Homo sapiens_hsa034102.74435897
6* Hippo signaling pathway_Homo sapiens_hsa043902.25370557
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18518932
8DNA replication_Homo sapiens_hsa030302.12927309
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.12611800
10Axon guidance_Homo sapiens_hsa043602.09365788
11* Basal cell carcinoma_Homo sapiens_hsa052172.06053941
12Galactose metabolism_Homo sapiens_hsa000521.98328288
13Tight junction_Homo sapiens_hsa045301.88636320
14Synaptic vesicle cycle_Homo sapiens_hsa047211.88521385
15Bladder cancer_Homo sapiens_hsa052191.79268337
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78805834
17* Hedgehog signaling pathway_Homo sapiens_hsa043401.74859320
18Nicotine addiction_Homo sapiens_hsa050331.73956988
19Long-term potentiation_Homo sapiens_hsa047201.69458954
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68913894
21Vitamin B6 metabolism_Homo sapiens_hsa007501.67544802
22Glioma_Homo sapiens_hsa052141.67129375
23Gap junction_Homo sapiens_hsa045401.65828235
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59641601
25Nucleotide excision repair_Homo sapiens_hsa034201.59067357
26Adherens junction_Homo sapiens_hsa045201.57515377
27* Melanogenesis_Homo sapiens_hsa049161.57042528
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52892245
29Circadian entrainment_Homo sapiens_hsa047131.50345806
30One carbon pool by folate_Homo sapiens_hsa006701.50275143
31GABAergic synapse_Homo sapiens_hsa047271.49803704
32Gastric acid secretion_Homo sapiens_hsa049711.49552697
33Endometrial cancer_Homo sapiens_hsa052131.48874403
34Nitrogen metabolism_Homo sapiens_hsa009101.46213829
35Salivary secretion_Homo sapiens_hsa049701.45260532
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45188985
37Fatty acid biosynthesis_Homo sapiens_hsa000611.44290170
38Glutamatergic synapse_Homo sapiens_hsa047241.41071950
39* Proteoglycans in cancer_Homo sapiens_hsa052051.34563290
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33617970
41Dopaminergic synapse_Homo sapiens_hsa047281.32761218
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32358449
43ErbB signaling pathway_Homo sapiens_hsa040121.32299934
44Focal adhesion_Homo sapiens_hsa045101.30822149
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29629041
46* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29453142
47* Wnt signaling pathway_Homo sapiens_hsa043101.28180342
48Renal cell carcinoma_Homo sapiens_hsa052111.27991741
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27969108
50Olfactory transduction_Homo sapiens_hsa047401.27742301
51ECM-receptor interaction_Homo sapiens_hsa045121.27521201
52Small cell lung cancer_Homo sapiens_hsa052221.23828495
53Steroid biosynthesis_Homo sapiens_hsa001001.23168121
54Biosynthesis of amino acids_Homo sapiens_hsa012301.20003970
55Dorso-ventral axis formation_Homo sapiens_hsa043201.19164169
56Amphetamine addiction_Homo sapiens_hsa050311.18214973
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17725634
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16880260
59Estrogen signaling pathway_Homo sapiens_hsa049151.16294759
60Homologous recombination_Homo sapiens_hsa034401.15815225
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15224112
62GnRH signaling pathway_Homo sapiens_hsa049121.14763317
63Colorectal cancer_Homo sapiens_hsa052101.14721731
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12940612
65Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12125175
66Oxytocin signaling pathway_Homo sapiens_hsa049211.10737814
67Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10426170
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09323569
69MicroRNAs in cancer_Homo sapiens_hsa052061.08157777
70Notch signaling pathway_Homo sapiens_hsa043301.08112814
71Rap1 signaling pathway_Homo sapiens_hsa040151.06811376
72Cholinergic synapse_Homo sapiens_hsa047251.04599619
73Endocytosis_Homo sapiens_hsa041441.03557820
74Phenylalanine metabolism_Homo sapiens_hsa003601.03528961
75Long-term depression_Homo sapiens_hsa047301.02398266
76Huntingtons disease_Homo sapiens_hsa050161.01961223
77VEGF signaling pathway_Homo sapiens_hsa043701.01485706
78Insulin secretion_Homo sapiens_hsa049110.99969008
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99827237
80Dilated cardiomyopathy_Homo sapiens_hsa054140.98850056
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.98841016
82Folate biosynthesis_Homo sapiens_hsa007900.98762573
83Cocaine addiction_Homo sapiens_hsa050300.98513103
84Arginine and proline metabolism_Homo sapiens_hsa003300.98436930
85Cardiac muscle contraction_Homo sapiens_hsa042600.98362888
86Oocyte meiosis_Homo sapiens_hsa041140.95837839
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95587569
88Chronic myeloid leukemia_Homo sapiens_hsa052200.92647894
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.92304947
90Morphine addiction_Homo sapiens_hsa050320.92236972
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89422186
92Fanconi anemia pathway_Homo sapiens_hsa034600.89284278
93beta-Alanine metabolism_Homo sapiens_hsa004100.87904844
94Pyrimidine metabolism_Homo sapiens_hsa002400.86187285
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.85846166
96Bile secretion_Homo sapiens_hsa049760.85081631
97Oxidative phosphorylation_Homo sapiens_hsa001900.83348636
98Renin secretion_Homo sapiens_hsa049240.83143374
99RNA polymerase_Homo sapiens_hsa030200.80128285
100Amoebiasis_Homo sapiens_hsa051460.78668091
101Choline metabolism in cancer_Homo sapiens_hsa052310.78653371
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78412697
103Phototransduction_Homo sapiens_hsa047440.78319707
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.78077941
105Pancreatic cancer_Homo sapiens_hsa052120.77644634
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.77367595
107Ovarian steroidogenesis_Homo sapiens_hsa049130.76755157
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.76742156
109Tyrosine metabolism_Homo sapiens_hsa003500.75701365
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.75624556
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74335735
112mTOR signaling pathway_Homo sapiens_hsa041500.74185344
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74060276
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74040265
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73946912
116* Pathways in cancer_Homo sapiens_hsa052000.73153900
117Thyroid cancer_Homo sapiens_hsa052160.73110044
118Ras signaling pathway_Homo sapiens_hsa040140.72976970
119Sphingolipid metabolism_Homo sapiens_hsa006000.71634660
120Melanoma_Homo sapiens_hsa052180.70844020
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70700051
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69666120
123Vibrio cholerae infection_Homo sapiens_hsa051100.67969877
124Non-small cell lung cancer_Homo sapiens_hsa052230.67621925
125Basal transcription factors_Homo sapiens_hsa030220.66552905
126Parkinsons disease_Homo sapiens_hsa050120.65344732
127cAMP signaling pathway_Homo sapiens_hsa040240.65162061
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65070211
129Serotonergic synapse_Homo sapiens_hsa047260.64894207
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64695772
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62586014
132TGF-beta signaling pathway_Homo sapiens_hsa043500.62550363
133Calcium signaling pathway_Homo sapiens_hsa040200.61319123
134Mineral absorption_Homo sapiens_hsa049780.59017273
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57604232
136Starch and sucrose metabolism_Homo sapiens_hsa005000.56786879
137Insulin signaling pathway_Homo sapiens_hsa049100.56663319
138Chemical carcinogenesis_Homo sapiens_hsa052040.56594983
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56050830
140MAPK signaling pathway_Homo sapiens_hsa040100.55993704
141Linoleic acid metabolism_Homo sapiens_hsa005910.54325730
142Alzheimers disease_Homo sapiens_hsa050100.53022130
143Metabolic pathways_Homo sapiens_hsa011000.52739045
144Prion diseases_Homo sapiens_hsa050200.51268555
145Thyroid hormone synthesis_Homo sapiens_hsa049180.51138139
146Shigellosis_Homo sapiens_hsa051310.50862602
147N-Glycan biosynthesis_Homo sapiens_hsa005100.49162308
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48171567
149Viral myocarditis_Homo sapiens_hsa054160.48005325
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47716164
151Purine metabolism_Homo sapiens_hsa002300.47433191
152Non-homologous end-joining_Homo sapiens_hsa034500.46682025
153Retinol metabolism_Homo sapiens_hsa008300.46337974
154AMPK signaling pathway_Homo sapiens_hsa041520.46304764
155Pentose phosphate pathway_Homo sapiens_hsa000300.45678140
156Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45305124
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44982749
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44487033
159Glucagon signaling pathway_Homo sapiens_hsa049220.42465019
1602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42071067
161Glycosaminoglycan degradation_Homo sapiens_hsa005310.40836658
162Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40525642
163Taste transduction_Homo sapiens_hsa047420.37717307
164Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37179151
165Histidine metabolism_Homo sapiens_hsa003400.37121672
166RNA degradation_Homo sapiens_hsa030180.37051818
167Cysteine and methionine metabolism_Homo sapiens_hsa002700.36918761
168Lysine degradation_Homo sapiens_hsa003100.35676112

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