WNT8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071997.45823364
2establishment of tissue polarity (GO:0007164)7.28726246
3establishment of planar polarity (GO:0001736)7.28726246
4lung epithelium development (GO:0060428)6.21978908
5organ growth (GO:0035265)5.88883923
6negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.72637448
7midbrain development (GO:0030901)5.72388334
8hematopoietic stem cell proliferation (GO:0071425)5.50872337
9cell proliferation involved in metanephros development (GO:0072203)5.39211456
10mesenchymal-epithelial cell signaling (GO:0060638)5.16472208
11regulation of non-canonical Wnt signaling pathway (GO:2000050)5.08618251
12regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.05693176
13embryonic foregut morphogenesis (GO:0048617)5.01524687
14regulation of mesenchymal cell apoptotic process (GO:2001053)4.97392442
15lens fiber cell development (GO:0070307)4.86896226
16negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.73186966
17negative regulation of DNA-templated transcription, elongation (GO:0032785)4.73186966
18dopaminergic neuron differentiation (GO:0071542)4.70868618
19paraxial mesoderm development (GO:0048339)4.69625050
20somite development (GO:0061053)4.67480819
21limb bud formation (GO:0060174)4.66493422
22retinal ganglion cell axon guidance (GO:0031290)4.61004308
23thalamus development (GO:0021794)4.48626278
24lung-associated mesenchyme development (GO:0060484)4.47846858
25cartilage morphogenesis (GO:0060536)4.44075813
26intraciliary transport (GO:0042073)4.36896914
27neuroblast proliferation (GO:0007405)4.29710830
28renal system development (GO:0072001)4.29301826
29dendritic spine morphogenesis (GO:0060997)4.28483844
30lateral sprouting from an epithelium (GO:0060601)4.27275074
31DNA unwinding involved in DNA replication (GO:0006268)4.18682426
32otic vesicle formation (GO:0030916)4.18660082
33regulation of somitogenesis (GO:0014807)4.17644703
34mesenchymal cell proliferation (GO:0010463)4.13756541
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.08896877
36embryonic camera-type eye development (GO:0031076)4.03318669
37kidney morphogenesis (GO:0060993)4.02392764
38radial glial cell differentiation (GO:0060019)4.01061784
39artery development (GO:0060840)3.96620512
40epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.96410619
41endocardial cushion morphogenesis (GO:0003203)3.92532683
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.91908924
43positive regulation of canonical Wnt signaling pathway (GO:0090263)3.80161956
44positive regulation of oligodendrocyte differentiation (GO:0048714)3.79897201
45lung lobe morphogenesis (GO:0060463)3.76559027
46dorsal/ventral neural tube patterning (GO:0021904)3.76530047
47DNA integration (GO:0015074)3.73675618
48cell proliferation involved in kidney development (GO:0072111)3.73609373
49DNA replication checkpoint (GO:0000076)3.72316830
50positive regulation of gastrulation (GO:2000543)3.67943171
51pyrimidine nucleobase catabolic process (GO:0006208)3.65124499
52astrocyte differentiation (GO:0048708)3.64231278
53branching involved in salivary gland morphogenesis (GO:0060445)3.60334630
54neuronal stem cell maintenance (GO:0097150)3.58948050
55negative regulation of RNA splicing (GO:0033119)3.58688198
56DNA strand elongation involved in DNA replication (GO:0006271)3.56974608
57positive regulation of neuroblast proliferation (GO:0002052)3.53457093
58convergent extension (GO:0060026)3.51953784
59negative regulation of mRNA processing (GO:0050686)3.49080982
60mesenchyme morphogenesis (GO:0072132)3.46147520
61camera-type eye morphogenesis (GO:0048593)3.45927840
62kinetochore assembly (GO:0051382)3.45255083
63branching involved in labyrinthine layer morphogenesis (GO:0060670)3.42308845
64organ induction (GO:0001759)3.39895484
65axon extension involved in axon guidance (GO:0048846)3.39196422
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.39196422
67notochord development (GO:0030903)3.38473414
68neural precursor cell proliferation (GO:0061351)3.37902001
69post-anal tail morphogenesis (GO:0036342)3.35295713
70positive regulation of embryonic development (GO:0040019)3.34691272
71DNA strand elongation (GO:0022616)3.32582470
72midgut development (GO:0007494)3.31841821
73cornea development in camera-type eye (GO:0061303)3.29698144
74kinetochore organization (GO:0051383)3.26463615
75DNA double-strand break processing (GO:0000729)3.25605372
76negative regulation of oligodendrocyte differentiation (GO:0048715)3.23919915
77planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18932437
78viral transcription (GO:0019083)3.18558841
79regulation of sister chromatid cohesion (GO:0007063)3.17867512
80urogenital system development (GO:0001655)3.17466333
81genitalia morphogenesis (GO:0035112)3.17150371
82cilium movement (GO:0003341)3.14388105
83negative regulation of smooth muscle cell differentiation (GO:0051151)3.12544737
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.11308114
85heart valve formation (GO:0003188)3.10306475
86non-canonical Wnt signaling pathway (GO:0035567)3.09287340
87embryonic hindlimb morphogenesis (GO:0035116)3.08998888
88axonal fasciculation (GO:0007413)3.08455319
89regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.08174695
90negative regulation of axon guidance (GO:1902668)3.07077816
91prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.05150339
92epithelial cilium movement (GO:0003351)3.03614907
93cell proliferation in forebrain (GO:0021846)3.03481850
94regulation of oligodendrocyte differentiation (GO:0048713)3.02975746
95negative regulation of translation, ncRNA-mediated (GO:0040033)3.02888897
96regulation of translation, ncRNA-mediated (GO:0045974)3.02888897
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.02888897
98meiotic chromosome segregation (GO:0045132)3.01999481
99establishment of nucleus localization (GO:0040023)3.01740286
100hindlimb morphogenesis (GO:0035137)2.97530550
101embryonic digestive tract morphogenesis (GO:0048557)2.96858417
102hindbrain development (GO:0030902)2.96495876
103translational termination (GO:0006415)2.96145508
104glomerular basement membrane development (GO:0032836)2.95217008
105myotube differentiation (GO:0014902)2.95027779
106prostate gland growth (GO:0060736)2.94963109
107positive regulation of Wnt signaling pathway (GO:0030177)2.94135754
108epithelial tube branching involved in lung morphogenesis (GO:0060441)2.92582655
109inner ear receptor stereocilium organization (GO:0060122)2.90480554
110neuron fate determination (GO:0048664)2.87675153
111Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.87383057
112cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.86854210
113short-term memory (GO:0007614)2.86295988
114embryonic forelimb morphogenesis (GO:0035115)2.86175190
115regulation of NFAT protein import into nucleus (GO:0051532)2.85457299
116nonmotile primary cilium assembly (GO:0035058)2.83269168
117protein localization to kinetochore (GO:0034501)2.83121391
118regulation of establishment of planar polarity (GO:0090175)2.82172589
119cell surface receptor signaling pathway involved in heart development (GO:0061311)2.81819884
120axis elongation (GO:0003401)2.81427344
121DNA replication-dependent nucleosome assembly (GO:0006335)2.81146765
122DNA replication-dependent nucleosome organization (GO:0034723)2.81146765
123epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80837551
124epithelial cell fate commitment (GO:0072148)2.80174272
125cell fate commitment involved in formation of primary germ layer (GO:0060795)2.79773613
126positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.79248914
127positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77019350
128somatic stem cell division (GO:0048103)2.76486804
129histone H3-K9 methylation (GO:0051567)2.75832934
130establishment of integrated proviral latency (GO:0075713)2.75756011
131peptidyl-lysine dimethylation (GO:0018027)2.75688890
132synaptic vesicle endocytosis (GO:0048488)2.75472960
133cochlea morphogenesis (GO:0090103)2.74853302
134mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74465397
135attachment of spindle microtubules to kinetochore (GO:0008608)2.73900140
136cell migration involved in heart development (GO:0060973)2.73694036
137positive regulation of smoothened signaling pathway (GO:0045880)2.73083315
138regulation of organ formation (GO:0003156)2.73008295
139protein localization to chromosome, centromeric region (GO:0071459)2.72805158
140histone H2A acetylation (GO:0043968)2.70945520
141negative regulation of circadian rhythm (GO:0042754)2.70564902
142regulation of axon guidance (GO:1902667)2.69818060
143negative regulation of cell fate specification (GO:0009996)2.69728625
144nucleosome disassembly (GO:0006337)2.68839194
145protein-DNA complex disassembly (GO:0032986)2.68839194
146left/right pattern formation (GO:0060972)2.68652018
147neuron fate commitment (GO:0048663)2.68616868
148telomere maintenance via semi-conservative replication (GO:0032201)2.68015820
149cerebral cortex development (GO:0021987)2.67728196
150cilium morphogenesis (GO:0060271)2.67718039
151regulation of centrosome duplication (GO:0010824)2.66742737
152inner ear morphogenesis (GO:0042472)2.66562162
153nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66343723
154piRNA metabolic process (GO:0034587)2.65199719
155smoothened signaling pathway (GO:0007224)2.64228903
156canonical Wnt signaling pathway (GO:0060070)2.63722279
157forebrain neuron differentiation (GO:0021879)2.63696683
158dorsal/ventral axis specification (GO:0009950)2.62878552
159axoneme assembly (GO:0035082)2.62854091
160negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.62621217
161male meiosis (GO:0007140)2.62146287
162motile cilium assembly (GO:0044458)2.61922537
163positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.60364236
164positive regulation of cell cycle G2/M phase transition (GO:1902751)2.60364236
165cilium assembly (GO:0042384)2.59537914
166negative regulation of mRNA metabolic process (GO:1903312)2.58484800
167neuronal ion channel clustering (GO:0045161)2.57782938
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.57782381
169stem cell proliferation (GO:0072089)2.57601994
170cardiovascular system development (GO:0072358)2.56647365
171developmental induction (GO:0031128)2.56219946
172cranial nerve morphogenesis (GO:0021602)2.55980191
173dentate gyrus development (GO:0021542)2.55838717
174spinal cord association neuron differentiation (GO:0021527)2.55480540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.91936596
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.93495231
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.76144944
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.95416703
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.71042187
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23546223
7* EZH2_27304074_Chip-Seq_ESCs_Mouse3.22488500
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.09494256
9EZH2_22144423_ChIP-Seq_EOC_Human3.00094151
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.88004593
11TAF15_26573619_Chip-Seq_HEK293_Human2.85763036
12* CBX2_27304074_Chip-Seq_ESCs_Mouse2.85741212
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76630579
14PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.73386044
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55320794
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51454931
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45810683
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43071408
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.42232624
20KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.39917385
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38849027
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38849027
23* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38346789
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34308944
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32751761
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.28756781
27* TP53_20018659_ChIP-ChIP_R1E_Mouse2.27907254
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.27022531
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24517585
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10295745
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08608321
32FUS_26573619_Chip-Seq_HEK293_Human2.06049742
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02936026
34* EZH2_27294783_Chip-Seq_ESCs_Mouse2.02404216
35* RING1B_27294783_Chip-Seq_NPCs_Mouse1.98913901
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92070835
37XRN2_22483619_ChIP-Seq_HELA_Human1.88258758
38* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88087412
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80302667
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73907528
41OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.71988337
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71183010
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70745488
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.63374284
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.60918780
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59985512
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59985512
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59363155
49RNF2_27304074_Chip-Seq_NSC_Mouse1.59227445
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.55941042
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.53204789
52SOX9_26525672_Chip-Seq_HEART_Mouse1.51706336
53TBX3_20139965_ChIP-Seq_ESCs_Mouse1.51283428
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50046289
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50007837
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49640217
57TBX3_20139965_ChIP-Seq_MESCs_Mouse1.49449092
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.49079112
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48891153
60IGF1R_20145208_ChIP-Seq_DFB_Human1.47837222
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41523432
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.41102066
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36097846
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.34173088
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34152024
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34012281
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33756141
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33257949
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32401357
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30447727
71CIITA_25753668_ChIP-Seq_RAJI_Human1.30311313
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30178453
73TTF2_22483619_ChIP-Seq_HELA_Human1.29586351
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28826234
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28088247
76* P300_19829295_ChIP-Seq_ESCs_Human1.27908555
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22957485
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22846922
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.22761380
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22381147
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21508414
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20222948
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19362600
84AR_21909140_ChIP-Seq_LNCAP_Human1.18800068
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17795562
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16751034
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16326508
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14878172
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.11899684
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11883002
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11055719
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10741401
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.10629747
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09960358
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09594422
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08605183
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08199132
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06788910
99KDM2B_26808549_Chip-Seq_K562_Human1.06269155
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05484755
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05484755
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05484755
103TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02590892
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00488526
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00353707
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00345508
107PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00030610
108* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98435715
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97601335
110CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97461503
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96810985
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95809251
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95608666
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95206562
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94657074
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94461862
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94102199
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93567391
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93307360
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.92865472
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92511239
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.92485483
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90395063
124RXR_22108803_ChIP-Seq_LS180_Human0.89666811
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89243750
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88901966
127MYC_18940864_ChIP-ChIP_HL60_Human0.88655622
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88588967
129EWS_26573619_Chip-Seq_HEK293_Human0.88184016
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.84194125
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.82526779
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79887587
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79569974
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77674839
135ZNF274_21170338_ChIP-Seq_K562_Hela0.75208760
136AR_21572438_ChIP-Seq_LNCaP_Human0.74088514
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.73759504
138ELK4_26923725_Chip-Seq_MESODERM_Mouse0.73571404
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.73252623
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.72108641
141POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.71386650
142SOX3_22085726_ChIP-Seq_NPCs_Mouse0.70926081
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70599142
144E2F1_21310950_ChIP-Seq_MCF-7_Human0.70357063
145POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.70158058
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.69885896
147CTCF_27219007_Chip-Seq_Bcells_Human0.69875249
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.68250562
149ZNF263_19887448_ChIP-Seq_K562_Human0.68001293
150WDR5_24793694_ChIP-Seq_LNCAP_Human0.66575628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.76517437
2MP0010030_abnormal_orbit_morphology5.01313558
3MP0003283_abnormal_digestive_organ4.76254344
4MP0002234_abnormal_pharynx_morphology3.92003773
5MP0002102_abnormal_ear_morphology3.90746476
6MP0000537_abnormal_urethra_morphology3.46112505
7MP0002282_abnormal_trachea_morphology3.11541965
8MP0005377_hearing/vestibular/ear_phenot3.02423191
9MP0003878_abnormal_ear_physiology3.02423191
10MP0001529_abnormal_vocalization2.90853062
11MP0009053_abnormal_anal_canal2.90221686
12MP0000778_abnormal_nervous_system2.69642026
13MP0003938_abnormal_ear_development2.33003028
14MP0002249_abnormal_larynx_morphology2.26308915
15MP0002938_white_spotting2.13082209
16MP0005423_abnormal_somatic_nervous2.11117161
17MP0002653_abnormal_ependyma_morphology2.10960296
18MP0003136_yellow_coat_color2.07057423
19MP0003122_maternal_imprinting2.03644418
20MP0003890_abnormal_embryonic-extraembry2.01679194
21MP0005257_abnormal_intraocular_pressure1.99269949
22MP0003880_abnormal_central_pattern1.95614231
23MP0000049_abnormal_middle_ear1.86583147
24MP0002751_abnormal_autonomic_nervous1.81887587
25MP0000569_abnormal_digit_pigmentation1.80916701
26MP0005076_abnormal_cell_differentiation1.72008804
27MP0001849_ear_inflammation1.70505166
28MP0000383_abnormal_hair_follicle1.65030357
29MP0003315_abnormal_perineum_morphology1.64151408
30MP0003937_abnormal_limbs/digits/tail_de1.61365299
31MP0001293_anophthalmia1.58561236
32MP0000026_abnormal_inner_ear1.56397149
33MP0001661_extended_life_span1.55665571
34MP0003718_maternal_effect1.54995646
35MP0000762_abnormal_tongue_morphology1.51789635
36MP0003121_genomic_imprinting1.44882275
37MP0003115_abnormal_respiratory_system1.40570051
38MP0008932_abnormal_embryonic_tissue1.39841520
39MP0005248_abnormal_Harderian_gland1.38590049
40MP0001346_abnormal_lacrimal_gland1.34248964
41MP0003119_abnormal_digestive_system1.32331193
42MP0000428_abnormal_craniofacial_morphol1.31775446
43MP0001286_abnormal_eye_development1.31731996
44MP0003755_abnormal_palate_morphology1.27020071
45MP0009780_abnormal_chondrocyte_physiolo1.26482463
46MP0002295_abnormal_pulmonary_circulatio1.26193133
47MP0000462_abnormal_digestive_system1.25243289
48MP0003861_abnormal_nervous_system1.24968555
49MP0002233_abnormal_nose_morphology1.24816113
50MP0003111_abnormal_nucleus_morphology1.23964609
51MP0003385_abnormal_body_wall1.23700372
52MP0002932_abnormal_joint_morphology1.23665041
53MP0002092_abnormal_eye_morphology1.17105511
54MP0000534_abnormal_ureter_morphology1.16056943
55MP0003943_abnormal_hepatobiliary_system1.15203957
56MP0002116_abnormal_craniofacial_bone1.13346370
57MP0006276_abnormal_autonomic_nervous1.13245730
58MP0003646_muscle_fatigue1.12289938
59MP0006292_abnormal_olfactory_placode1.10824683
60MP0003942_abnormal_urinary_system1.10756829
61MP0003077_abnormal_cell_cycle1.10662925
62MP0000631_abnormal_neuroendocrine_gland1.09916509
63MP0010678_abnormal_skin_adnexa1.09654965
64MP0000467_abnormal_esophagus_morphology1.09608551
65MP0008789_abnormal_olfactory_epithelium1.09061064
66MP0002697_abnormal_eye_size1.06657182
67MP0009379_abnormal_foot_pigmentation1.04357154
68MP0001340_abnormal_eyelid_morphology1.01740474
69MP0003935_abnormal_craniofacial_develop1.01717024
70MP0004859_abnormal_synaptic_plasticity1.01252755
71MP0003123_paternal_imprinting0.98605736
72MP0005171_absent_coat_pigmentation0.97557071
73MP0004742_abnormal_vestibular_system0.96269361
74MP0010307_abnormal_tumor_latency0.95864715
75MP0002085_abnormal_embryonic_tissue0.94279713
76MP0002111_abnormal_tail_morphology0.92774238
77MP0005499_abnormal_olfactory_system0.92352540
78MP0005394_taste/olfaction_phenotype0.92352540
79MP0004133_heterotaxia0.91797477
80MP0010094_abnormal_chromosome_stability0.90740399
81MP0009703_decreased_birth_body0.90153807
82MP0005367_renal/urinary_system_phenotyp0.88772904
83MP0000516_abnormal_urinary_system0.88772904
84MP0000733_abnormal_muscle_development0.87875219
85MP0001963_abnormal_hearing_physiology0.87513690
86MP0001697_abnormal_embryo_size0.86758835
87MP0002638_abnormal_pupillary_reflex0.86350162
88MP0004957_abnormal_blastocyst_morpholog0.85018546
89MP0002109_abnormal_limb_morphology0.84888852
90MP0008057_abnormal_DNA_replication0.84872318
91MP0004381_abnormal_hair_follicle0.83808864
92MP0008058_abnormal_DNA_repair0.81852359
93MP0002152_abnormal_brain_morphology0.81314856
94MP0005646_abnormal_pituitary_gland0.80001950
95MP0009250_abnormal_appendicular_skeleto0.79402580
96MP0002210_abnormal_sex_determination0.78834839
97MP0002009_preneoplasia0.78724804
98MP0002089_abnormal_postnatal_growth/wei0.77858697
99MP0005253_abnormal_eye_physiology0.77809537
100MP0000653_abnormal_sex_gland0.77253136
101MP0008961_abnormal_basal_metabolism0.76012103
102MP0002081_perinatal_lethality0.75532180
103MP0002098_abnormal_vibrissa_morphology0.75348994
104MP0001672_abnormal_embryogenesis/_devel0.74930700
105MP0005380_embryogenesis_phenotype0.74930700
106MP0005391_vision/eye_phenotype0.74659238
107MP0000955_abnormal_spinal_cord0.73397020
108MP0009672_abnormal_birth_weight0.73225061
109MP0002184_abnormal_innervation0.73112625
110MP0001502_abnormal_circadian_rhythm0.72688976
111MP0000579_abnormal_nail_morphology0.72554623
112MP0002084_abnormal_developmental_patter0.71503296
113MP0009384_cardiac_valve_regurgitation0.71051842
114MP0008007_abnormal_cellular_replicative0.67141178
115MP0004885_abnormal_endolymph0.64732846
116MP0000613_abnormal_salivary_gland0.64150815
117MP0003693_abnormal_embryo_hatching0.64148569
118MP0004134_abnormal_chest_morphology0.63956523
119MP0000163_abnormal_cartilage_morphology0.62653065
120MP0005508_abnormal_skeleton_morphology0.61972947
121MP0002752_abnormal_somatic_nervous0.61204093
122MP0000350_abnormal_cell_proliferation0.60427227
123MP0003137_abnormal_impulse_conducting0.59787109
124MP0005220_abnormal_exocrine_pancreas0.59454533
125MP0002882_abnormal_neuron_morphology0.58368337
126MP0005409_darkened_coat_color0.58333674
127MP0005187_abnormal_penis_morphology0.57826099
128MP0000647_abnormal_sebaceous_gland0.56996279
129MP0001299_abnormal_eye_distance/0.54194532
130MP0000432_abnormal_head_morphology0.53848392

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of incisors (HP:0011064)5.26794925
2Bilateral microphthalmos (HP:0007633)4.23248850
3Coronal craniosynostosis (HP:0004440)3.63350549
4Megalencephaly (HP:0001355)3.58346078
5Maternal diabetes (HP:0009800)3.56886489
6Trigonocephaly (HP:0000243)3.52645497
7Renal duplication (HP:0000075)3.30077852
8Bronchomalacia (HP:0002780)3.27716744
9Colon cancer (HP:0003003)3.22972677
10Pancreatic fibrosis (HP:0100732)3.12939870
11Tented upper lip vermilion (HP:0010804)3.09215789
12Neonatal short-limb short stature (HP:0008921)3.07105214
13Preaxial foot polydactyly (HP:0001841)3.04172320
14Supernumerary spleens (HP:0009799)2.97533496
15Anophthalmia (HP:0000528)2.95642940
16Alacrima (HP:0000522)2.95117425
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94073261
18Short 4th metacarpal (HP:0010044)2.94073261
19Anterior segment dysgenesis (HP:0007700)2.93841130
20Partial duplication of thumb phalanx (HP:0009944)2.89241857
21Increased nuchal translucency (HP:0010880)2.87065879
22Overriding aorta (HP:0002623)2.85188128
23Tubulointerstitial nephritis (HP:0001970)2.83633211
24High anterior hairline (HP:0009890)2.81785703
25Porencephaly (HP:0002132)2.79660466
26Abnormality of the labia minora (HP:0012880)2.79636657
27Abnormality of the incisor (HP:0000676)2.79239859
28Reticulocytopenia (HP:0001896)2.77742921
29Hyperacusis (HP:0010780)2.75192898
30Cutaneous finger syndactyly (HP:0010554)2.68645423
31Abnormality of incisor morphology (HP:0011063)2.66476899
32Skull defect (HP:0001362)2.62505329
33Decreased lacrimation (HP:0000633)2.62117791
34Partial duplication of the phalanx of hand (HP:0009999)2.61684653
35Occipital encephalocele (HP:0002085)2.60932382
36Upper limb muscle weakness (HP:0003484)2.60784788
37Pancreatic cysts (HP:0001737)2.58314685
38Broad finger (HP:0001500)2.57868821
39Preaxial hand polydactyly (HP:0001177)2.56466965
40Elfin facies (HP:0004428)2.56409405
41Absent radius (HP:0003974)2.54663984
42Stenosis of the external auditory canal (HP:0000402)2.53749469
43Broad thumb (HP:0011304)2.51589303
44Abnormality of cochlea (HP:0000375)2.51038259
45True hermaphroditism (HP:0010459)2.47531718
46Broad phalanges of the hand (HP:0009768)2.46427271
47Ependymoma (HP:0002888)2.46373950
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44837502
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44168902
50Hypotelorism (HP:0000601)2.42122579
51Aplasia involving bones of the extremities (HP:0009825)2.40816947
52Aplasia involving bones of the upper limbs (HP:0009823)2.40816947
53Aplasia of the phalanges of the hand (HP:0009802)2.40816947
54Morphological abnormality of the middle ear (HP:0008609)2.39907327
55Medulloblastoma (HP:0002885)2.39584502
56Turricephaly (HP:0000262)2.39349706
57Neoplasm of striated muscle (HP:0009728)2.39193463
58Cutaneous syndactyly (HP:0012725)2.38580605
59Broad phalanx (HP:0006009)2.35013189
60Ectopic kidney (HP:0000086)2.34973357
61Broad hallux (HP:0010055)2.33595181
62Cystic liver disease (HP:0006706)2.33421526
63Renovascular hypertension (HP:0100817)2.32870148
64Long foot (HP:0001833)2.32484046
65Tracheomalacia (HP:0002779)2.30978207
66Facial hemangioma (HP:0000329)2.29363409
67Oligodactyly (HP:0012165)2.28366013
68Protruding tongue (HP:0010808)2.28360990
69Septo-optic dysplasia (HP:0100842)2.28097043
70Narrow nasal bridge (HP:0000446)2.26594322
71Abdominal situs inversus (HP:0003363)2.26158367
72Abnormality of abdominal situs (HP:0011620)2.26158367
73Neoplasm of the heart (HP:0100544)2.24323013
74Vitreoretinal degeneration (HP:0000655)2.22842899
75Breast hypoplasia (HP:0003187)2.22114015
76Triphalangeal thumb (HP:0001199)2.21282933
77Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.20192876
78Short 5th finger (HP:0009237)2.18383906
79Absent septum pellucidum (HP:0001331)2.16776152
80Abnormality of the right ventricle (HP:0001707)2.16346388
81Polyphagia (HP:0002591)2.14707989
82Patellar aplasia (HP:0006443)2.13792150
83Abnormal ciliary motility (HP:0012262)2.13125768
84Acute lymphatic leukemia (HP:0006721)2.12788463
85Broad distal phalanx of finger (HP:0009836)2.12774570
86Anencephaly (HP:0002323)2.12485413
87Broad long bones (HP:0005622)2.12059132
88Oligodactyly (hands) (HP:0001180)2.09418967
89Midline defect of the nose (HP:0004122)2.09248472
90Tubulointerstitial abnormality (HP:0001969)2.08728855
91Abnormality of chromosome segregation (HP:0002916)2.08540417
92Abnormality of the musculature of the hand (HP:0001421)2.08239165
93Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08016198
94Leiomyosarcoma (HP:0100243)2.06863120
95Uterine leiomyosarcoma (HP:0002891)2.06863120
96Renal dysplasia (HP:0000110)2.05339654
97Aqueductal stenosis (HP:0002410)2.05050005
98Narrow forehead (HP:0000341)2.04635564
99Abnormality of the intervertebral disk (HP:0005108)2.04498469
100Cortical dysplasia (HP:0002539)2.04260494
101Abnormal respiratory motile cilium physiology (HP:0012261)2.03050577
102Atelectasis (HP:0100750)2.03001425
103Abnormality of the septum pellucidum (HP:0007375)2.02596377
104Astrocytoma (HP:0009592)2.02230729
105Abnormality of the astrocytes (HP:0100707)2.02230729
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.01985754
107Thickened helices (HP:0000391)2.01728762
108Abnormality of the 4th metacarpal (HP:0010012)2.00851229
109Postaxial foot polydactyly (HP:0001830)2.00604117
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.99743022
111Arterial tortuosity (HP:0005116)1.98845452
112Abnormality of the diencephalon (HP:0010662)1.98474876
113Synostosis of carpal bones (HP:0005048)1.97351250
114Holoprosencephaly (HP:0001360)1.96801786
115Hepatoblastoma (HP:0002884)1.96682725
116Abnormality of the dental root (HP:0006486)1.96036071
117Taurodontia (HP:0000679)1.96036071
118Abnormality of permanent molar morphology (HP:0011071)1.96036071
119Exotropia (HP:0000577)1.95535006
120Aplasia/Hypoplasia of the patella (HP:0006498)1.95137275
121Aplasia cutis congenita (HP:0001057)1.94975497
122Wide anterior fontanel (HP:0000260)1.94742134
123Morphological abnormality of the inner ear (HP:0011390)1.94283074
124Mixed hearing impairment (HP:0000410)1.94144511
125Bifid tongue (HP:0010297)1.92898880
126Highly arched eyebrow (HP:0002553)1.90334120
127Glioma (HP:0009733)1.90201129
128Broad foot (HP:0001769)1.89985657
129Hallux valgus (HP:0001822)1.89774661
130Renal hypoplasia (HP:0000089)1.89115958
131Atresia of the external auditory canal (HP:0000413)1.88983677
132Broad toe (HP:0001837)1.88830155
133Sclerocornea (HP:0000647)1.88753311
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.88210866
135Obsessive-compulsive behavior (HP:0000722)1.87976421
136Overlapping toe (HP:0001845)1.87881060
137Rib fusion (HP:0000902)1.87620585
138Hypoplasia of the ulna (HP:0003022)1.87249904
139Carpal synostosis (HP:0009702)1.87206564
140Recurrent corneal erosions (HP:0000495)1.86988822
141Rhinitis (HP:0012384)1.86850015
142Flat cornea (HP:0007720)1.86147857
143Duplication of thumb phalanx (HP:0009942)1.85127808
144Growth hormone deficiency (HP:0000824)1.84572549
145Hand muscle atrophy (HP:0009130)1.83745825
146Absent epiphyses (HP:0010577)1.82916812
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82916812
148Concave nail (HP:0001598)1.80391746
149Aplasia involving forearm bones (HP:0009822)1.80060698
150Absent forearm bone (HP:0003953)1.80060698
151Visceral angiomatosis (HP:0100761)1.79654517
152Deviation of the hallux (HP:0010051)1.79619401
153Megalocornea (HP:0000485)1.79606793
154Slender build (HP:0001533)1.79300463
155Diastasis recti (HP:0001540)1.79185992
156Abnormality of the middle phalanges of the toes (HP:0010183)1.78629872
157Esophageal atresia (HP:0002032)1.78321805
158Nephroblastoma (Wilms tumor) (HP:0002667)1.78243453
159Rhabdomyosarcoma (HP:0002859)1.77748819
160Chorioretinal coloboma (HP:0000567)1.75834969
161Abnormality of molar morphology (HP:0011070)1.75052010
162Abnormality of molar (HP:0011077)1.75052010
163Ulnar bowing (HP:0003031)1.74628503
164Abnormality of the parietal bone (HP:0002696)1.73855699
165Hip dysplasia (HP:0001385)1.73513455
166Bifid scrotum (HP:0000048)1.73155558
167Nephronophthisis (HP:0000090)1.72676527
168Abnormal lung lobation (HP:0002101)1.71597520
169Hemivertebrae (HP:0002937)1.69894466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.51152639
2BUB14.55744727
3EPHA34.08318663
4KSR13.95414213
5EPHA43.81016933
6STK163.09921251
7FGFR22.63252475
8SIK32.59737095
9MKNK22.54906693
10CDC72.53301452
11MAP3K102.29555049
12BCR2.20136092
13TAF12.11812592
14ERBB22.07068136
15VRK21.99080699
16TLK11.99016361
17UHMK11.98227896
18NUAK11.95972459
19PLK41.91649140
20TNIK1.80019171
21PRKD31.78429355
22WNK31.76819125
23PASK1.74622774
24MARK11.71632799
25FGFR11.70426574
26NTRK21.62605689
27CCNB11.59122757
28SRPK11.54369544
29SMG11.54150137
30MELK1.52767300
31NEK11.49915736
32TGFBR11.48793920
33NEK21.47396262
34ZAK1.46442607
35MINK11.37707498
36CDK81.36990441
37TSSK61.34822106
38TRIM281.33771524
39WEE11.32361281
40BRSK21.32213387
41DYRK31.26347379
42PLK21.19185121
43BRD41.17967423
44NLK1.16684262
45BMPR1B1.13930563
46AKT21.10776387
47ERBB31.06212959
48PLK11.05977267
49CDK191.03014924
50DYRK21.02868295
51PINK11.01914468
52DYRK1B1.01018426
53STK30.95802324
54FGFR30.94630177
55TNK20.93366002
56CDK90.93241246
57MAP3K40.90975536
58EIF2AK10.87283394
59CSNK1A1L0.86008241
60SIK10.85146517
61VRK10.84924662
62PDK20.82474031
63ROCK20.82444674
64AURKB0.81587958
65LRRK20.81574418
66ICK0.80896790
67CHEK20.79940329
68TYRO30.79860130
69YES10.79039932
70PBK0.78478569
71PDGFRA0.78254959
72IRAK20.76803161
73CAMK1D0.76328312
74ROCK10.75604922
75CDK180.75398878
76MAPK130.74613775
77MKNK10.74227851
78BRSK10.73858647
79STK390.73179909
80AURKA0.72380610
81CSNK1G30.70092915
82PAK40.70030997
83LATS20.67554582
84NME20.67451222
85CDK120.67226313
86ACVR1B0.66610722
87ATM0.65865005
88EEF2K0.63751952
89CDK70.63386027
90MAPK150.63365120
91CASK0.59926541
92ATR0.59771416
93EIF2AK30.59574377
94CDK150.58961015
95LATS10.55970268
96CDK140.55763655
97CHEK10.53547158
98PRKDC0.51881232
99RAF10.51751137
100PLK30.50477646
101CDK11A0.50102941
102FER0.47869627
103CDK40.47349753
104TTK0.47344809
105CSNK1D0.47099885
106STK240.46706119
107PNCK0.45704006
108PTK60.45404907
109CDK10.44811964
110MTOR0.44728668
111LIMK10.42408373
112STK110.41555901
113IRAK10.40202811
114PRKCZ0.40191810
115LMTK20.39450908
116FGFR40.39027467
117STK38L0.37841476
118DMPK0.37010239
119EIF2AK20.36627579
120CDK20.36550809
121FGR0.35772661
122GSK3B0.34930286
123MAPK90.34648987
124MAP2K20.34030557
125CAMK1G0.33366153
126CSNK1G10.31643628
127MAPK100.31569928
128CLK10.31118591
129CSNK1G20.30843867
130CDK50.29250484
131INSRR0.26955553
132DYRK1A0.26242455
133PKN10.26180908
134BLK0.25397327
135SRC0.24491231
136MAP3K70.22940276
137SGK4940.21710987
138SGK2230.21710987

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052175.00678168
2DNA replication_Homo sapiens_hsa030304.52355160
3Nitrogen metabolism_Homo sapiens_hsa009103.65898401
4Spliceosome_Homo sapiens_hsa030403.58662726
5Notch signaling pathway_Homo sapiens_hsa043303.37789014
6Ribosome_Homo sapiens_hsa030103.16939698
7* Hippo signaling pathway_Homo sapiens_hsa043903.12292864
8* Hedgehog signaling pathway_Homo sapiens_hsa043403.02683920
9Mismatch repair_Homo sapiens_hsa034302.92038966
10Cell cycle_Homo sapiens_hsa041102.89125486
11Axon guidance_Homo sapiens_hsa043602.53121469
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37461113
13Base excision repair_Homo sapiens_hsa034102.14914126
14mRNA surveillance pathway_Homo sapiens_hsa030152.14600803
15* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.08152398
16* Wnt signaling pathway_Homo sapiens_hsa043102.04111251
17MicroRNAs in cancer_Homo sapiens_hsa052061.92081071
18* Melanogenesis_Homo sapiens_hsa049161.83407161
19Oocyte meiosis_Homo sapiens_hsa041141.76287868
20RNA transport_Homo sapiens_hsa030131.61592961
21Circadian rhythm_Homo sapiens_hsa047101.56920212
22Nucleotide excision repair_Homo sapiens_hsa034201.53072573
23Dorso-ventral axis formation_Homo sapiens_hsa043201.51990139
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46740738
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.46394815
26Propanoate metabolism_Homo sapiens_hsa006401.44145333
27Colorectal cancer_Homo sapiens_hsa052101.42654060
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37837400
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27915202
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26361702
31Lysine degradation_Homo sapiens_hsa003101.18083723
32* HTLV-I infection_Homo sapiens_hsa051661.17514016
33* Pathways in cancer_Homo sapiens_hsa052001.16465094
34TGF-beta signaling pathway_Homo sapiens_hsa043501.16235859
35Protein export_Homo sapiens_hsa030601.05660491
36Vitamin B6 metabolism_Homo sapiens_hsa007501.03151787
37Homologous recombination_Homo sapiens_hsa034401.02468635
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.01596928
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99708180
40Bladder cancer_Homo sapiens_hsa052190.99432123
41Gap junction_Homo sapiens_hsa045400.99322186
42Circadian entrainment_Homo sapiens_hsa047130.97210581
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96938329
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96033615
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95049694
46* Proteoglycans in cancer_Homo sapiens_hsa052050.94161841
47Dopaminergic synapse_Homo sapiens_hsa047280.93561434
48N-Glycan biosynthesis_Homo sapiens_hsa005100.91181364
49Thyroid cancer_Homo sapiens_hsa052160.91143151
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90250416
51Systemic lupus erythematosus_Homo sapiens_hsa053220.85722587
52Alcoholism_Homo sapiens_hsa050340.85271346
53Phototransduction_Homo sapiens_hsa047440.84140407
54Protein digestion and absorption_Homo sapiens_hsa049740.82387507
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80869751
56Fanconi anemia pathway_Homo sapiens_hsa034600.80690281
57Renal cell carcinoma_Homo sapiens_hsa052110.80487613
58Non-homologous end-joining_Homo sapiens_hsa034500.79977644
59ECM-receptor interaction_Homo sapiens_hsa045120.78894672
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78074625
61RNA polymerase_Homo sapiens_hsa030200.77570406
62RNA degradation_Homo sapiens_hsa030180.76326434
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75413567
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75154326
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73866464
66Tight junction_Homo sapiens_hsa045300.71816815
67One carbon pool by folate_Homo sapiens_hsa006700.71481494
68Prostate cancer_Homo sapiens_hsa052150.71299035
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70321351
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69617332
71Glioma_Homo sapiens_hsa052140.69551188
72Endometrial cancer_Homo sapiens_hsa052130.67427319
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65788157
74Adherens junction_Homo sapiens_hsa045200.64188402
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63919836
76Pyruvate metabolism_Homo sapiens_hsa006200.63241334
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62923470
78Arginine biosynthesis_Homo sapiens_hsa002200.62108205
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62028484
80AMPK signaling pathway_Homo sapiens_hsa041520.61351013
81Small cell lung cancer_Homo sapiens_hsa052220.61277985
82Chronic myeloid leukemia_Homo sapiens_hsa052200.60017038
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59380896
84Cocaine addiction_Homo sapiens_hsa050300.58650554
85GABAergic synapse_Homo sapiens_hsa047270.58336893
86Nicotine addiction_Homo sapiens_hsa050330.57177625
87Cardiac muscle contraction_Homo sapiens_hsa042600.57006351
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56277737
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56079059
90Glutamatergic synapse_Homo sapiens_hsa047240.55282704
91Sphingolipid metabolism_Homo sapiens_hsa006000.54627473
92Pyrimidine metabolism_Homo sapiens_hsa002400.51489566
93mTOR signaling pathway_Homo sapiens_hsa041500.51464143
94p53 signaling pathway_Homo sapiens_hsa041150.49529072
95Inositol phosphate metabolism_Homo sapiens_hsa005620.48911142
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48739738
97Non-small cell lung cancer_Homo sapiens_hsa052230.48254664
98Biosynthesis of amino acids_Homo sapiens_hsa012300.48086408
99Prion diseases_Homo sapiens_hsa050200.47130835
100Rap1 signaling pathway_Homo sapiens_hsa040150.46832409
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46581791
102Arginine and proline metabolism_Homo sapiens_hsa003300.45759841
103Olfactory transduction_Homo sapiens_hsa047400.45418718
104Melanoma_Homo sapiens_hsa052180.45320711
105beta-Alanine metabolism_Homo sapiens_hsa004100.45224064
106Phenylalanine metabolism_Homo sapiens_hsa003600.45196272
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44862179
108Viral carcinogenesis_Homo sapiens_hsa052030.44116896
109Purine metabolism_Homo sapiens_hsa002300.43390008
110Morphine addiction_Homo sapiens_hsa050320.43243866
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41525431
112Selenocompound metabolism_Homo sapiens_hsa004500.40697169
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40685861
114Butanoate metabolism_Homo sapiens_hsa006500.40378810
115Regulation of autophagy_Homo sapiens_hsa041400.39430243
116Fatty acid metabolism_Homo sapiens_hsa012120.37253365
117HIF-1 signaling pathway_Homo sapiens_hsa040660.35994338
118Type II diabetes mellitus_Homo sapiens_hsa049300.35937223
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35628714
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32393054
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31972806
122Viral myocarditis_Homo sapiens_hsa054160.31870531
123T cell receptor signaling pathway_Homo sapiens_hsa046600.31841293
124Steroid biosynthesis_Homo sapiens_hsa001000.31167977
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30017657
126Gastric acid secretion_Homo sapiens_hsa049710.29020483
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28626139
128Huntingtons disease_Homo sapiens_hsa050160.28442207
129Glucagon signaling pathway_Homo sapiens_hsa049220.28182515
130Choline metabolism in cancer_Homo sapiens_hsa052310.28006513
131Cholinergic synapse_Homo sapiens_hsa047250.27759317
132Pancreatic cancer_Homo sapiens_hsa052120.27466242
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.27042019
134Ras signaling pathway_Homo sapiens_hsa040140.23320069
135Basal transcription factors_Homo sapiens_hsa030220.23268644
136Amphetamine addiction_Homo sapiens_hsa050310.23233581
137FoxO signaling pathway_Homo sapiens_hsa040680.22760853
138ErbB signaling pathway_Homo sapiens_hsa040120.21794932
139Focal adhesion_Homo sapiens_hsa045100.21449381
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21412031
141Salivary secretion_Homo sapiens_hsa049700.20943927
142Oxytocin signaling pathway_Homo sapiens_hsa049210.20938279
143Carbon metabolism_Homo sapiens_hsa012000.20128929
144Epstein-Barr virus infection_Homo sapiens_hsa051690.18307089
145Fatty acid elongation_Homo sapiens_hsa000620.17353876

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