WNT9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.45385492
2motile cilium assembly (GO:0044458)8.53135146
3cilium movement (GO:0003341)7.97127711
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.91638864
5epithelial cilium movement (GO:0003351)6.76814474
6left/right pattern formation (GO:0060972)5.67271573
7plasma membrane repair (GO:0001778)5.64937450
8axoneme assembly (GO:0035082)5.23875297
9primary alcohol catabolic process (GO:0034310)4.81815031
10vitamin transmembrane transport (GO:0035461)4.74018632
11diterpenoid biosynthetic process (GO:0016102)4.50220344
12desmosome organization (GO:0002934)4.43053433
13hemidesmosome assembly (GO:0031581)4.41821446
14establishment of apical/basal cell polarity (GO:0035089)4.36159761
15glomerular epithelial cell development (GO:0072310)4.24891342
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.02641858
17pyrimidine-containing compound transmembrane transport (GO:0072531)3.87926908
18response to muscle activity (GO:0014850)3.84396200
19lung epithelium development (GO:0060428)3.83396586
20skeletal muscle fiber development (GO:0048741)3.79658665
21ethanol metabolic process (GO:0006067)3.76773479
22actin-myosin filament sliding (GO:0033275)3.73867906
23muscle filament sliding (GO:0030049)3.73867906
24establishment or maintenance of monopolar cell polarity (GO:0061339)3.71326478
25establishment of monopolar cell polarity (GO:0061162)3.71326478
26positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.68330679
27left/right axis specification (GO:0070986)3.67095684
28skeletal muscle adaptation (GO:0043501)3.61240376
29regulation of cilium movement (GO:0003352)3.57098065
30microtubule bundle formation (GO:0001578)3.54918965
31postsynaptic membrane organization (GO:0001941)3.54663026
32intraciliary transport (GO:0042073)3.53755862
33sarcomere organization (GO:0045214)3.52367256
34striated muscle atrophy (GO:0014891)3.40009176
35muscle cell fate commitment (GO:0042693)3.31281142
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31065796
37vocalization behavior (GO:0071625)3.30796065
38positive regulation of myoblast differentiation (GO:0045663)3.29611604
39carnitine transmembrane transport (GO:1902603)3.28187737
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.27436116
41axon extension involved in axon guidance (GO:0048846)3.27436116
42establishment of tissue polarity (GO:0007164)3.27197368
43establishment of planar polarity (GO:0001736)3.27197368
44glutamate secretion (GO:0014047)3.26977396
45actin-mediated cell contraction (GO:0070252)3.22312361
46ventricular system development (GO:0021591)3.20834577
47skeletal muscle contraction (GO:0003009)3.18343402
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.17865538
49regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.17806542
50myotube differentiation (GO:0014902)3.15565647
51myotube cell development (GO:0014904)3.15560753
52response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.15418418
53collagen fibril organization (GO:0030199)3.14655425
54regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.14587194
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.13637442
56regulation of skeletal muscle contraction (GO:0014819)3.11508459
57cilium organization (GO:0044782)3.09115951
58terpenoid biosynthetic process (GO:0016114)3.08386288
59cytoplasmic microtubule organization (GO:0031122)3.07941922
60chondrocyte proliferation (GO:0035988)3.05390130
61regulation of relaxation of muscle (GO:1901077)3.04346284
62cell adhesion mediated by integrin (GO:0033627)3.04169969
63myoblast fusion (GO:0007520)3.02734316
64multicellular organismal water homeostasis (GO:0050891)2.98572396
65cilium assembly (GO:0042384)2.98018246
66bundle of His cell to Purkinje myocyte communication (GO:0086069)2.95835890
67amino-acid betaine transport (GO:0015838)2.95530151
68carnitine transport (GO:0015879)2.95530151
69axon extension (GO:0048675)2.94773924
70positive regulation of myotube differentiation (GO:0010831)2.94564052
71muscle cell migration (GO:0014812)2.93724390
72muscle atrophy (GO:0014889)2.93651832
73stress fiber assembly (GO:0043149)2.93091326
74negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92664190
75kidney mesenchyme development (GO:0072074)2.91500043
76protein localization to synapse (GO:0035418)2.91449947
77syncytium formation (GO:0006949)2.90353960
78endodermal cell differentiation (GO:0035987)2.87768932
79cardiac myofibril assembly (GO:0055003)2.87512834
80muscle contraction (GO:0006936)2.86606026
81neuromuscular junction development (GO:0007528)2.85347680
82adherens junction assembly (GO:0034333)2.85158795
83regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83256578
84cellular component assembly involved in morphogenesis (GO:0010927)2.82450060
85hippo signaling (GO:0035329)2.80228810
86retinoic acid metabolic process (GO:0042573)2.79602751
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.78421576
88skeletal muscle tissue development (GO:0007519)2.75846844
89layer formation in cerebral cortex (GO:0021819)2.74480152
90actomyosin structure organization (GO:0031032)2.74158092
91sperm capacitation (GO:0048240)2.74121318
92synaptic vesicle maturation (GO:0016188)2.71737593
93cardiac muscle contraction (GO:0060048)2.71564071
94one-carbon compound transport (GO:0019755)2.71285873
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70382882
96focal adhesion assembly (GO:0048041)2.70080452
97cell-substrate adherens junction assembly (GO:0007045)2.70080452
98actin filament-based movement (GO:0030048)2.69159848
99muscle cell cellular homeostasis (GO:0046716)2.68146742
100negative regulation of fatty acid transport (GO:2000192)2.67805394
101renal filtration (GO:0097205)2.67777529
102epithelial cell-cell adhesion (GO:0090136)2.67425484
103regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65880244
104syncytium formation by plasma membrane fusion (GO:0000768)2.64608441
105protein heterotrimerization (GO:0070208)2.64543874
106regulation of synaptic vesicle exocytosis (GO:2000300)2.64474871
107ethanol oxidation (GO:0006069)2.63644245
108quaternary ammonium group transport (GO:0015697)2.63347216
109hypotonic response (GO:0006971)2.63188621
110negative regulation of T cell differentiation in thymus (GO:0033085)2.63041536
111regulation of the force of heart contraction (GO:0002026)2.62272416
112cell-substrate junction assembly (GO:0007044)2.60610604
113synaptic vesicle exocytosis (GO:0016079)2.60272510
114neuron projection extension (GO:1990138)2.59795598
115sequestering of extracellular ligand from receptor (GO:0035581)2.58380392
116muscle fiber development (GO:0048747)2.58001346
117sarcoplasmic reticulum calcium ion transport (GO:0070296)2.57942682
118positive regulation of synapse maturation (GO:0090129)2.57749093
119positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.57720374
120positive regulation of fibroblast migration (GO:0010763)2.57449306
121regulation of glutamate receptor signaling pathway (GO:1900449)2.57316747
122adherens junction organization (GO:0034332)2.56770960
123glomerular basement membrane development (GO:0032836)2.56497662
124carnitine metabolic process (GO:0009437)2.55881997
125notochord development (GO:0030903)2.54328529
126myofibril assembly (GO:0030239)2.54242098
127regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53076896
128protein targeting to plasma membrane (GO:0072661)2.52690897
129muscle organ morphogenesis (GO:0048644)2.51168306
130negative regulation of catenin import into nucleus (GO:0035414)2.51057508
131regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50863976
132establishment or maintenance of bipolar cell polarity (GO:0061245)2.50512390
133establishment or maintenance of apical/basal cell polarity (GO:0035088)2.50512390
134polarized epithelial cell differentiation (GO:0030859)2.49837621
135apical protein localization (GO:0045176)2.49828007
136muscle system process (GO:0003012)2.49383749
137regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.49355032
138water homeostasis (GO:0030104)2.48944175
139myoblast migration (GO:0051451)2.47939351
140axonal fasciculation (GO:0007413)2.47200135
141dendritic spine morphogenesis (GO:0060997)2.46859783
142bone trabecula formation (GO:0060346)2.46597785
143microtubule-based movement (GO:0007018)2.46165538
144membrane assembly (GO:0071709)2.45964871
145locomotory exploration behavior (GO:0035641)2.45266230
146negative regulation of potassium ion transmembrane transport (GO:1901380)2.44936190
147regulation of interleukin-5 production (GO:0032674)2.44336880
148positive regulation of skeletal muscle tissue development (GO:0048643)2.44062023
149asymmetric protein localization (GO:0008105)2.42812217
150regulation of cell communication by electrical coupling (GO:0010649)2.42302127
151glycogen catabolic process (GO:0005980)2.41874988
152establishment of nucleus localization (GO:0040023)2.41029653
153metanephric mesenchyme development (GO:0072075)2.38268167
154positive regulation of axon extension (GO:0045773)2.37723450
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36450573
156neuronal action potential propagation (GO:0019227)2.36228654
157cell communication by electrical coupling (GO:0010644)2.36209785
158striated muscle contraction (GO:0006941)2.35918527
159cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.34923789
160response to inactivity (GO:0014854)2.34859635
161regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.34828512
162regulation of dendritic spine morphogenesis (GO:0061001)2.32640900
163activation of protein kinase A activity (GO:0034199)2.31510526
164neuromuscular synaptic transmission (GO:0007274)2.30776456
165regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30707102
166positive regulation of cardiac muscle cell differentiation (GO:2000727)2.29037380
167positive regulation of dendrite morphogenesis (GO:0050775)2.28868056
168ephrin receptor signaling pathway (GO:0048013)2.28302225
169innervation (GO:0060384)2.27869410
170cell communication involved in cardiac conduction (GO:0086065)2.27382288
171regulation of cardiac muscle cell differentiation (GO:2000725)2.26967890
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26293342
173axonemal dynein complex assembly (GO:0070286)11.6997036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.24139223
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.10647516
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.97826418
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93717631
5EZH2_22144423_ChIP-Seq_EOC_Human2.91944571
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69389721
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51440913
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41388581
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41388581
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26315458
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13254834
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11311396
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08424109
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.07713401
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05891954
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05419467
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03859327
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02038716
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.00126688
20* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.95325030
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93927998
22* TP53_20018659_ChIP-ChIP_R1E_Mouse1.93704691
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.91668379
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.91482331
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83141654
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82780722
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.80430286
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78000185
29DROSHA_22980978_ChIP-Seq_HELA_Human1.76429685
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.75649596
31* RUNX1_27514584_Chip-Seq_MCF-7_Human1.71312930
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.70261085
33TP53_16413492_ChIP-PET_HCT116_Human1.69928588
34* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67059480
35* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67059480
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.65626840
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65464037
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65425262
39* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64684016
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63668345
41SMC4_20622854_ChIP-Seq_HELA_Human1.62880792
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61601710
43GBX2_23144817_ChIP-Seq_PC3_Human1.57814402
44TP63_22573176_ChIP-Seq_HFKS_Human1.57298882
45CLOCK_20551151_ChIP-Seq_293T_Human1.55361349
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53328118
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52225059
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51398515
49* ERG_21242973_ChIP-ChIP_JURKAT_Human1.50214287
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.50170486
51TP53_18474530_ChIP-ChIP_U2OS_Human1.49725911
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48129474
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46939833
54CJUN_26792858_Chip-Seq_BT549_Human1.46542651
55* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44468901
56KDM2B_26808549_Chip-Seq_K562_Human1.42478237
57* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41560187
58CTCF_27219007_Chip-Seq_Bcells_Human1.41399789
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40622144
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40550090
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.39306211
62GATA3_24758297_ChIP-Seq_MCF-7_Human1.38500230
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37440437
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37157642
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36797316
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.35074627
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34514814
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33921298
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33921298
70KLF5_25053715_ChIP-Seq_YYC3_Human1.30192102
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29827337
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28952800
73* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27206524
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26938139
75* TP63_23658742_ChIP-Seq_EP156T_Human1.26889225
76SOX2_20726797_ChIP-Seq_SW620_Human1.26179182
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.21940235
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21707217
79* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21631823
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.20622391
81TP53_22127205_ChIP-Seq_IMR90_Human1.19853250
82ZNF263_19887448_ChIP-Seq_K562_Human1.19168280
83ZNF274_21170338_ChIP-Seq_K562_Hela1.19115872
84AR_21572438_ChIP-Seq_LNCaP_Human1.18968886
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.18437916
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17299040
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17240005
88* ATF3_27146783_Chip-Seq_COLON_Human1.16508751
89* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16265237
90* AHR_22903824_ChIP-Seq_MCF-7_Human1.15780162
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15159832
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14872099
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.14581545
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14513535
95* ARNT_22903824_ChIP-Seq_MCF-7_Human1.13846148
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13409258
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.13035681
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12615938
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12096324
100* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11984400
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11048923
102P68_20966046_ChIP-Seq_HELA_Human1.10919708
103* TP53_23651856_ChIP-Seq_MEFs_Mouse1.10861490
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09234574
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08947650
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.08812356
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08406320
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06479850
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.06143920
110TBX20_22080862_ChIP-Seq_HEART_Mouse1.06143920
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05236789
112RXR_22108803_ChIP-Seq_LS180_Human1.04872928
113* CREB1_26743006_Chip-Seq_LNCaP_Human1.04804116
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04196465
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03837251
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.03005460
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02865552
118ISL1_27105846_Chip-Seq_CPCs_Mouse1.02701265
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02126676
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.01608879
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01211327
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00706377
123* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00592946
124BRD4_25478319_ChIP-Seq_HGPS_Human0.99208243
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97754389
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97734311
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.97506858
128AR_19668381_ChIP-Seq_PC3_Human0.96991953
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96664073
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94272611
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93929124
132RACK7_27058665_Chip-Seq_MCF-7_Human0.93466368
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93301460
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.92929800
135SMAD4_21799915_ChIP-Seq_A2780_Human0.92776049
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.92745540
137PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92245160
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92197799
139REST_21632747_ChIP-Seq_MESCs_Mouse0.91461857
140* LXR_22292898_ChIP-Seq_THP-1_Human0.90999137
141* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90962382
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90948501
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90648918
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90033382
145GATA6_25053715_ChIP-Seq_YYC3_Human0.88967466
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88207631
147* UBF1/2_26484160_Chip-Seq_HMECs_Human0.87113858
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.85321351
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85220399
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83438060
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.81671554
152* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80691164
153* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80076372
154SA1_27219007_Chip-Seq_ERYTHROID_Human0.79661801
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77840501
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.77647107
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77130958
158FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76958349
159NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76122716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.01282165
2MP0000751_myopathy3.45638126
3MP0005623_abnormal_meninges_morphology3.29808197
4MP0004859_abnormal_synaptic_plasticity3.26781372
5MP0005275_abnormal_skin_tensile3.00769347
6MP0004270_analgesia3.00441210
7MP0005503_abnormal_tendon_morphology2.72628250
8MP0002837_dystrophic_cardiac_calcinosis2.68642472
9MP0004145_abnormal_muscle_electrophysio2.52209059
10MP0000749_muscle_degeneration2.51907876
11MP0004272_abnormal_basement_membrane2.45646980
12MP0003705_abnormal_hypodermis_morpholog2.26369443
13MP0000733_abnormal_muscle_development2.25250603
14MP0008875_abnormal_xenobiotic_pharmacok2.14705149
15MP0000579_abnormal_nail_morphology2.14225897
16MP0000750_abnormal_muscle_regeneration2.11618438
17MP0004233_abnormal_muscle_weight2.02661656
18MP0002653_abnormal_ependyma_morphology1.97994480
19MP0000747_muscle_weakness1.97287699
20MP0003950_abnormal_plasma_membrane1.95891342
21MP0004087_abnormal_muscle_fiber1.87644719
22MP0004084_abnormal_cardiac_muscle1.85873293
23MP0000759_abnormal_skeletal_muscle1.82676430
24MP0003879_abnormal_hair_cell1.76590326
25MP0003279_aneurysm1.72425675
26MP0000013_abnormal_adipose_tissue1.71396361
27MP0004858_abnormal_nervous_system1.69980538
28MP0010678_abnormal_skin_adnexa1.69975207
29MP0002108_abnormal_muscle_morphology1.67232712
30MP0008789_abnormal_olfactory_epithelium1.65458630
31MP0002332_abnormal_exercise_endurance1.64403096
32MP0003635_abnormal_synaptic_transmissio1.60937437
33MP0001958_emphysema1.60872054
34MP0003566_abnormal_cell_adhesion1.60197740
35MP0000383_abnormal_hair_follicle1.60045087
36MP0000566_synostosis1.60010107
37MP0001542_abnormal_bone_strength1.58759665
38MP0002106_abnormal_muscle_physiology1.57787915
39MP0004036_abnormal_muscle_relaxation1.54333915
40MP0005369_muscle_phenotype1.53232505
41MP0003385_abnormal_body_wall1.52240414
42MP0000467_abnormal_esophagus_morphology1.50434320
43MP0004043_abnormal_pH_regulation1.46681787
44MP0000678_abnormal_parathyroid_gland1.43248145
45MP0005620_abnormal_muscle_contractility1.43131913
46MP0003880_abnormal_central_pattern1.41309558
47MP0000537_abnormal_urethra_morphology1.41167418
48MP0005451_abnormal_body_composition1.39776240
49MP0002269_muscular_atrophy1.38366524
50MP0003941_abnormal_skin_development1.37558677
51* MP0009780_abnormal_chondrocyte_physiolo1.37113166
52MP0006054_spinal_hemorrhage1.35650042
53MP0004484_altered_response_of1.35374054
54MP0002734_abnormal_mechanical_nocicepti1.33995093
55MP0001968_abnormal_touch/_nociception1.32291929
56MP0002234_abnormal_pharynx_morphology1.30066636
57MP0003091_abnormal_cell_migration1.29583331
58MP0003045_fibrosis1.29459717
59MP0002796_impaired_skin_barrier1.29397286
60MP0001849_ear_inflammation1.26947338
61MP0000534_abnormal_ureter_morphology1.26258636
62MP0006138_congestive_heart_failure1.26097108
63MP0005330_cardiomyopathy1.25746073
64MP0002896_abnormal_bone_mineralization1.24969911
65MP0004264_abnormal_extraembryonic_tissu1.24966822
66MP0004782_abnormal_surfactant_physiolog1.24943249
67MP0004215_abnormal_myocardial_fiber1.23995078
68MP0005257_abnormal_intraocular_pressure1.23355242
69MP0004133_heterotaxia1.23140564
70MP0009384_cardiac_valve_regurgitation1.21844606
71MP0009053_abnormal_anal_canal1.20693035
72MP0008775_abnormal_heart_ventricle1.18709834
73MP0005508_abnormal_skeleton_morphology1.18656648
74MP0002063_abnormal_learning/memory/cond1.18651546
75MP0002098_abnormal_vibrissa_morphology1.17842294
76MP0009250_abnormal_appendicular_skeleto1.17357373
77MP0001299_abnormal_eye_distance/1.17144422
78MP0002972_abnormal_cardiac_muscle1.15226179
79MP0005248_abnormal_Harderian_gland1.14975307
80MP0004130_abnormal_muscle_cell1.13904444
81MP0003283_abnormal_digestive_organ1.13385568
82MP0002132_abnormal_respiratory_system1.10719191
83MP0005409_darkened_coat_color1.10350676
84MP0005083_abnormal_biliary_tract1.09913976
85MP0001346_abnormal_lacrimal_gland1.09152972
86MP0001984_abnormal_olfaction1.08092528
87MP0003453_abnormal_keratinocyte_physiol1.07115593
88MP0003942_abnormal_urinary_system1.06149862
89MP0003115_abnormal_respiratory_system1.04961657
90MP0005165_increased_susceptibility_to1.03555534
91MP0002295_abnormal_pulmonary_circulatio1.02080924
92MP0003122_maternal_imprinting0.99058872
93MP0010352_gastrointestinal_tract_polyps0.98747018
94MP0003329_amyloid_beta_deposits0.97707176
95MP0010030_abnormal_orbit_morphology0.97105698
96MP0005501_abnormal_skin_physiology0.96295850
97MP0010630_abnormal_cardiac_muscle0.95926749
98MP0002909_abnormal_adrenal_gland0.95339056
99MP0002127_abnormal_cardiovascular_syste0.92976866
100MP0001348_abnormal_lacrimal_gland0.92665967
101MP0000003_abnormal_adipose_tissue0.92058402
102MP0009745_abnormal_behavioral_response0.92044072
103MP0002184_abnormal_innervation0.90628763
104MP0002735_abnormal_chemical_nociception0.90101035
105MP0003755_abnormal_palate_morphology0.89708392
106MP0010368_abnormal_lymphatic_system0.89680024
107MP0003137_abnormal_impulse_conducting0.88252627
108MP0002736_abnormal_nociception_after0.87458869
109MP0000428_abnormal_craniofacial_morphol0.87403195
110MP0002249_abnormal_larynx_morphology0.87144917
111MP0000778_abnormal_nervous_system0.86289931
112MP0005385_cardiovascular_system_phenoty0.85543017
113MP0001544_abnormal_cardiovascular_syste0.85543017
114MP0010234_abnormal_vibrissa_follicle0.84664915
115MP0006036_abnormal_mitochondrial_physio0.82865908
116MP0004085_abnormal_heartbeat0.81998626
117MP0000516_abnormal_urinary_system0.80648073
118MP0005367_renal/urinary_system_phenotyp0.80648073
119MP0000266_abnormal_heart_morphology0.80450302
120MP0010771_integument_phenotype0.79958240
121MP0002064_seizures0.79683256
122MP0003646_muscle_fatigue0.79680812
123MP0001440_abnormal_grooming_behavior0.78193426
124MP0002282_abnormal_trachea_morphology0.77983261
125MP0001216_abnormal_epidermal_layer0.77127944
126MP0002876_abnormal_thyroid_physiology0.76836015
127MP0002168_other_aberrant_phenotype0.76034474
128MP0000762_abnormal_tongue_morphology0.75303946
129MP0002572_abnormal_emotion/affect_behav0.74811553
130MP0000767_abnormal_smooth_muscle0.74719482
131MP0005023_abnormal_wound_healing0.74251771
132MP0005375_adipose_tissue_phenotype0.73831684
133MP0000163_abnormal_cartilage_morphology0.73545189
134MP0002060_abnormal_skin_morphology0.72008166
135MP0005499_abnormal_olfactory_system0.71293057
136MP0005394_taste/olfaction_phenotype0.71293057
137MP0005076_abnormal_cell_differentiation0.69462722
138MP0002233_abnormal_nose_morphology0.69180507
139MP0002089_abnormal_postnatal_growth/wei0.68487033
140MP0003806_abnormal_nucleotide_metabolis0.68066934
141MP0004811_abnormal_neuron_physiology0.68029134
142* MP0002932_abnormal_joint_morphology0.64156673

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.26408568
2Abnormal respiratory epithelium morphology (HP:0012253)7.54381595
3Abnormal respiratory motile cilium morphology (HP:0005938)7.54381595
4Abnormal respiratory motile cilium physiology (HP:0012261)7.20227813
5Absent/shortened dynein arms (HP:0200106)7.11233168
6Dynein arm defect of respiratory motile cilia (HP:0012255)7.11233168
7Abnormal ciliary motility (HP:0012262)7.05377259
8Rhinitis (HP:0012384)6.63199539
9Chronic bronchitis (HP:0004469)5.20066206
10Protrusio acetabuli (HP:0003179)4.80983236
11Premature rupture of membranes (HP:0001788)4.55922965
12Bronchiectasis (HP:0002110)4.50823080
13Type 1 muscle fiber predominance (HP:0003803)4.30173303
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.26379222
15Round ear (HP:0100830)4.25257135
16Nasal polyposis (HP:0100582)4.24378704
17Muscle fiber splitting (HP:0003555)4.22624001
18Muscle fiber inclusion bodies (HP:0100299)4.13766625
19Distal arthrogryposis (HP:0005684)3.99566377
20Hyporeflexia of lower limbs (HP:0002600)3.79175419
21Difficulty running (HP:0009046)3.59202792
22Abnormality of the nasal mucosa (HP:0000433)3.58451992
23Difficulty climbing stairs (HP:0003551)3.53674238
24Increased connective tissue (HP:0009025)3.45687903
25Nemaline bodies (HP:0003798)3.44287591
26Shallow orbits (HP:0000586)3.39965396
27Abnormality of the calf musculature (HP:0001430)3.35005697
28Fetal akinesia sequence (HP:0001989)3.28708135
29Ulnar deviation of the wrist (HP:0003049)3.27719284
30Exercise-induced myalgia (HP:0003738)3.14976507
31Atrophic scars (HP:0001075)3.13669940
32Increased variability in muscle fiber diameter (HP:0003557)3.01695735
33Calf muscle hypertrophy (HP:0008981)2.96380168
34Abnormality of skeletal muscle fiber size (HP:0012084)2.96102144
35Muscle hypertrophy of the lower extremities (HP:0008968)2.92387552
36EMG: myopathic abnormalities (HP:0003458)2.85096423
37Calcaneovalgus deformity (HP:0001848)2.83777831
38Sudden death (HP:0001699)2.83113689
39Infertility (HP:0000789)2.80994704
40Malignant hyperthermia (HP:0002047)2.80288394
41Mildly elevated creatine phosphokinase (HP:0008180)2.75532115
42Right ventricular cardiomyopathy (HP:0011663)2.75477919
43Fragile skin (HP:0001030)2.74658470
44Distal lower limb amyotrophy (HP:0008944)2.74342102
45Popliteal pterygium (HP:0009756)2.73953922
46Exercise-induced muscle cramps (HP:0003710)2.72673141
47Aortic dissection (HP:0002647)2.69289630
48Absent phalangeal crease (HP:0006109)2.68160132
49Hip contracture (HP:0003273)2.67197246
50Male infertility (HP:0003251)2.65138994
51Neck muscle weakness (HP:0000467)2.63471085
52Abnormality of dentin (HP:0010299)2.63412129
53Broad metatarsal (HP:0001783)2.62045144
54Spinal rigidity (HP:0003306)2.55033645
55Deformed tarsal bones (HP:0008119)2.54873665
56Lower limb amyotrophy (HP:0007210)2.54140310
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.47471600
58Wrist flexion contracture (HP:0001239)2.47409379
59Gowers sign (HP:0003391)2.47048475
60Myotonia (HP:0002486)2.46068759
61Occipital encephalocele (HP:0002085)2.43389322
62Ankle contracture (HP:0006466)2.42356159
63Scapular winging (HP:0003691)2.42232361
64Myopathic facies (HP:0002058)2.41522856
65Distal lower limb muscle weakness (HP:0009053)2.40430959
66Thin ribs (HP:0000883)2.39078204
67Recurrent otitis media (HP:0000403)2.37251177
68Bladder diverticulum (HP:0000015)2.36317896
69Cerebral aneurysm (HP:0004944)2.34511259
70Bronchitis (HP:0012387)2.32509918
71Chronic sinusitis (HP:0011109)2.32437225
72Rimmed vacuoles (HP:0003805)2.31384427
73Abnormality of the calcaneus (HP:0008364)2.30534361
74Atelectasis (HP:0100750)2.30449334
75Hyperkalemia (HP:0002153)2.30326536
76Fatigable weakness (HP:0003473)2.28667626
77Abnormality of the neuromuscular junction (HP:0003398)2.28667626
78Abnormal finger flexion creases (HP:0006143)2.28001279
79Bell-shaped thorax (HP:0001591)2.24192162
80Buphthalmos (HP:0000557)2.23620595
81Pterygium (HP:0001059)2.22837090
82Bundle branch block (HP:0011710)2.21808151
83Myoglobinuria (HP:0002913)2.20779939
84Mitral valve prolapse (HP:0001634)2.19500534
85Hyperactive renin-angiotensin system (HP:0000841)2.16324281
86Distal upper limb amyotrophy (HP:0007149)2.15594987
87Upper limb amyotrophy (HP:0009129)2.15594987
88Dilatation of the ascending aorta (HP:0005111)2.13879708
89Cervical subluxation (HP:0003308)2.13596887
90Slender build (HP:0001533)2.12470374
91Asymmetric septal hypertrophy (HP:0001670)2.12274607
92Hypercortisolism (HP:0001578)2.09440208
93Aplasia of the musculature (HP:0100854)2.09204543
94Soft skin (HP:0000977)2.09126647
95Knee flexion contracture (HP:0006380)2.07836690
96Breech presentation (HP:0001623)2.05660878
97Genu recurvatum (HP:0002816)2.02461748
98Focal motor seizures (HP:0011153)2.01209126
99Limited hip movement (HP:0008800)2.00406420
100Nonprogressive disorder (HP:0003680)2.00179995
101Recurrent sinusitis (HP:0011108)2.00118739
102Vascular tortuosity (HP:0004948)1.99482432
103Tarsal synostosis (HP:0008368)1.99472994
104Rhabdomyolysis (HP:0003201)1.98813548
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98402100
106Peritonitis (HP:0002586)1.96567020
107Shoulder girdle muscle weakness (HP:0003547)1.96012105
108Pancreatic fibrosis (HP:0100732)1.95703788
109Neonatal short-limb short stature (HP:0008921)1.95154253
110Weak cry (HP:0001612)1.94976905
111Aortic aneurysm (HP:0004942)1.94882029
112Achilles tendon contracture (HP:0001771)1.94284860
113Abnormality of the left ventricular outflow tract (HP:0011103)1.94036849
114Subaortic stenosis (HP:0001682)1.94036849
115Limb-girdle muscle atrophy (HP:0003797)1.91556440
116Proximal amyotrophy (HP:0007126)1.91108285
117Lip pit (HP:0100267)1.89569330
118Wormian bones (HP:0002645)1.89136162
119Ventricular tachycardia (HP:0004756)1.88324993
120Overgrowth (HP:0001548)1.88076045
121True hermaphroditism (HP:0010459)1.85981025
122Bulbar palsy (HP:0001283)1.85040886
123Akinesia (HP:0002304)1.84983896
124Lipoatrophy (HP:0100578)1.84567703
125Chin dimple (HP:0010751)1.84394828
126Atonic seizures (HP:0010819)1.83352399
127Short nail (HP:0001799)1.82166232
128Arterial tortuosity (HP:0005116)1.81194122
129Blue sclerae (HP:0000592)1.79376757
130Bronchomalacia (HP:0002780)1.76845212
131Abnormality of the distal phalanges of the toes (HP:0010182)1.76764164
132Synostosis involving bones of the lower limbs (HP:0009138)1.76278141
133Synostosis involving bones of the feet (HP:0009140)1.76278141
134Limb-girdle muscle weakness (HP:0003325)1.76253075
135Amniotic constriction ring (HP:0009775)1.75444863
136Abnormality of placental membranes (HP:0011409)1.75444863
137Abnormality of the foot musculature (HP:0001436)1.74941238
138Hyperextensible skin (HP:0000974)1.74768133
139Abnormal delivery (HP:0001787)1.73008481
140Hypoplastic ischia (HP:0003175)1.71318864
141Areflexia of lower limbs (HP:0002522)1.71043050
142EMG: neuropathic changes (HP:0003445)1.71030766
143Trismus (HP:0000211)1.70667206
144Abnormality of the Achilles tendon (HP:0005109)1.70616237
145Abnormal atrioventricular conduction (HP:0005150)1.67785294
146Diaphragmatic weakness (HP:0009113)1.66969719
147Foot dorsiflexor weakness (HP:0009027)1.66786590
148Cystic liver disease (HP:0006706)1.65276731
149Muscle stiffness (HP:0003552)1.64855138
150Glucose intolerance (HP:0000833)1.64789379
151Nephronophthisis (HP:0000090)1.63907272
152Abnormality of the shoulder girdle musculature (HP:0001435)1.62895549
153Dilated cardiomyopathy (HP:0001644)1.61203497
154Muscular dystrophy (HP:0003560)1.54482016
155Taurodontia (HP:0000679)1.52976583
156Abnormality of permanent molar morphology (HP:0011071)1.52976583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.56715507
2TTN3.52451835
3DAPK22.97905227
4MST1R2.86046169
5TRIB32.84125390
6MAP3K92.57379119
7EPHA42.41265232
8EPHB22.40696809
9MST42.34836803
10EPHA22.31507231
11SMG12.25840759
12MET2.25301124
13DDR22.23022876
14CASK2.17676568
15NTRK32.14045402
16EEF2K2.09856335
17LATS21.95495437
18ICK1.91953186
19RIPK11.77983057
20MOS1.73552482
21PRKD31.70375970
22MAP3K121.69046812
23DAPK31.65328355
24PLK21.64714212
25PAK31.63997151
26CCNB11.61615092
27FER1.61370521
28DMPK1.61315345
29KSR11.49656317
30PTK2B1.49169481
31PTK21.49137703
32NTRK11.47986908
33PDGFRA1.46440780
34PAK61.42899030
35MAP3K41.42557925
36PKN21.39305643
37CDK81.38091266
38MAP2K11.37731966
39PHKG21.36386493
40PHKG11.36386493
41PIK3CA1.35517860
42EPHB11.34432595
43PINK11.33795835
44MAP3K31.31174882
45DAPK11.30475033
46MUSK1.28130243
47OBSCN1.25748722
48LATS11.24402329
49PIM21.23416066
50MAP2K41.22677392
51KSR21.21603356
52MINK11.20450021
53CAMKK11.09686770
54PAK41.08350698
55BMPR1B1.08292295
56STK38L1.08186400
57LIMK11.04668895
58MAP3K71.01708973
59NEK11.00351070
60STK240.99421981
61CDK140.96208374
62CDK120.94011713
63ROCK20.93824796
64TGFBR10.92739062
65ILK0.91607081
66PTK60.91193799
67SIK20.90917769
68MAP3K20.90735285
69MAP3K60.90716811
70ROCK10.88241955
71RET0.87852901
72BMX0.85731828
73CDK180.84918752
74PAK20.84632759
75CDK150.84632307
76BCR0.84044042
77STK380.83264806
78PIK3CG0.81021197
79MARK10.77970323
80NME10.77921476
81MYLK0.76371418
82CDK50.75884881
83BCKDK0.75727596
84CAMK2G0.75206431
85LMTK20.74875723
86MAPK120.74704445
87CDK11A0.74249111
88CAMKK20.74111731
89CAMK2A0.73752859
90FGFR10.72485651
91SIK10.71546457
92AKT20.71532123
93TAOK10.70347341
94PDK40.69931384
95PDK30.69931384
96RPS6KB20.67998619
97PRKCI0.66793902
98PBK0.65836147
99TESK10.65797497
100MAP3K50.64111670
101CDK190.62256571
102NEK60.58635640
103GRK50.57568762
104RIPK40.57155595
105MAPKAPK30.56689815
106LRRK20.54394286
107CAMK2B0.52340545
108CDK90.52308666
109PRKCE0.51064831
110TYRO30.50941896
111ERN10.49226039
112MAPK70.49113590
113STK110.48575755
114PRKCH0.48242760
115CAMK10.47082766
116PRKCG0.46848633
117MTOR0.44935425
118PRPF4B0.44367180
119PRKAA10.42453168
120ERBB30.41725432
121STK30.41562861
122CAMK2D0.40141800
123MAP3K100.38800942
124EPHA30.38776962
125TRPM70.38755507
126SRC0.38048831
127SGK10.37924300
128ERBB40.37721282
129PRKAA20.36944406
130RPS6KA20.36580598
131CDC42BPA0.36399742
132MAP2K70.35410794
133ARAF0.34445626
134MARK20.34262322
135IRAK30.33865088
136ABL20.33368924
137PRKD20.30103053
138PRKD10.30021270
139GRK10.29963734
140RPS6KC10.29533366
141RPS6KL10.29533366
142NEK90.27864972
143MAPKAPK50.27353880
144RPS6KA60.22720405
145STK100.20846902
146TTK0.20165941
147MAP2K30.19567310
148AURKA0.17809969
149MAP2K60.17779869
150FLT30.16292605

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.85050722
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.59589380
3Dilated cardiomyopathy_Homo sapiens_hsa054142.58856578
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54243708
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.45965982
6Histidine metabolism_Homo sapiens_hsa003402.42799844
7Tyrosine metabolism_Homo sapiens_hsa003502.29241930
8ECM-receptor interaction_Homo sapiens_hsa045122.07825859
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.05144967
10beta-Alanine metabolism_Homo sapiens_hsa004101.98140413
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97524919
12Chemical carcinogenesis_Homo sapiens_hsa052041.94521540
13Focal adhesion_Homo sapiens_hsa045101.87906316
14Synaptic vesicle cycle_Homo sapiens_hsa047211.82783459
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80803863
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80193910
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80000157
18Oxytocin signaling pathway_Homo sapiens_hsa049211.75467856
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72859892
20Long-term potentiation_Homo sapiens_hsa047201.61198645
21Bladder cancer_Homo sapiens_hsa052191.58092416
22Circadian entrainment_Homo sapiens_hsa047131.56520343
23Axon guidance_Homo sapiens_hsa043601.56157718
24Glutathione metabolism_Homo sapiens_hsa004801.55817430
25Nicotine addiction_Homo sapiens_hsa050331.51573266
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50949116
27Cardiac muscle contraction_Homo sapiens_hsa042601.48661051
28* Proteoglycans in cancer_Homo sapiens_hsa052051.48177513
29Glioma_Homo sapiens_hsa052141.47177456
30Tight junction_Homo sapiens_hsa045301.44550007
31* Hippo signaling pathway_Homo sapiens_hsa043901.44304996
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42479257
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42252145
34Amphetamine addiction_Homo sapiens_hsa050311.39266946
35GnRH signaling pathway_Homo sapiens_hsa049121.37956384
36Salivary secretion_Homo sapiens_hsa049701.37705741
37Gastric acid secretion_Homo sapiens_hsa049711.37610043
38Fructose and mannose metabolism_Homo sapiens_hsa000511.37504214
39* Melanogenesis_Homo sapiens_hsa049161.36715116
40Insulin secretion_Homo sapiens_hsa049111.33728147
41Amoebiasis_Homo sapiens_hsa051461.32144377
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31476402
43Adherens junction_Homo sapiens_hsa045201.31464997
44Folate biosynthesis_Homo sapiens_hsa007901.28802683
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28523719
46Gap junction_Homo sapiens_hsa045401.27268989
47Arginine and proline metabolism_Homo sapiens_hsa003301.27069893
48Renin secretion_Homo sapiens_hsa049241.20921969
49Dopaminergic synapse_Homo sapiens_hsa047281.19861183
50Pentose phosphate pathway_Homo sapiens_hsa000301.16831988
51Calcium signaling pathway_Homo sapiens_hsa040201.16594133
52Cholinergic synapse_Homo sapiens_hsa047251.16258528
53Glutamatergic synapse_Homo sapiens_hsa047241.15696537
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14338285
55Estrogen signaling pathway_Homo sapiens_hsa049151.11994394
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10918275
57Huntingtons disease_Homo sapiens_hsa050161.09366021
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08078692
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07741882
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06628366
61Fatty acid degradation_Homo sapiens_hsa000711.06069318
62Olfactory transduction_Homo sapiens_hsa047401.05380131
63* Basal cell carcinoma_Homo sapiens_hsa052171.04647580
64GABAergic synapse_Homo sapiens_hsa047271.03627984
65Sphingolipid metabolism_Homo sapiens_hsa006000.98818660
66Arginine biosynthesis_Homo sapiens_hsa002200.98044273
67Morphine addiction_Homo sapiens_hsa050320.97636953
68ErbB signaling pathway_Homo sapiens_hsa040120.96890530
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.96694196
70* Wnt signaling pathway_Homo sapiens_hsa043100.96469856
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95933940
72Insulin resistance_Homo sapiens_hsa049310.95584243
73Long-term depression_Homo sapiens_hsa047300.95077666
74* Hedgehog signaling pathway_Homo sapiens_hsa043400.94802669
75Melanoma_Homo sapiens_hsa052180.94767420
76Rap1 signaling pathway_Homo sapiens_hsa040150.93943272
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93911422
78Carbon metabolism_Homo sapiens_hsa012000.93154797
79Starch and sucrose metabolism_Homo sapiens_hsa005000.92971863
80Glucagon signaling pathway_Homo sapiens_hsa049220.92600544
81VEGF signaling pathway_Homo sapiens_hsa043700.91922953
82MAPK signaling pathway_Homo sapiens_hsa040100.88845227
83Vibrio cholerae infection_Homo sapiens_hsa051100.88565389
84Renal cell carcinoma_Homo sapiens_hsa052110.88210669
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86568914
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86061037
87Insulin signaling pathway_Homo sapiens_hsa049100.85654159
88Protein digestion and absorption_Homo sapiens_hsa049740.85084558
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84316870
90Biosynthesis of amino acids_Homo sapiens_hsa012300.83980173
91mTOR signaling pathway_Homo sapiens_hsa041500.82682310
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81514486
93Small cell lung cancer_Homo sapiens_hsa052220.81388591
94cAMP signaling pathway_Homo sapiens_hsa040240.81319473
95Taste transduction_Homo sapiens_hsa047420.79177430
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.78841793
97Endometrial cancer_Homo sapiens_hsa052130.77625112
98Cocaine addiction_Homo sapiens_hsa050300.77441352
99Sulfur relay system_Homo sapiens_hsa041220.75783753
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70992057
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70874949
102TGF-beta signaling pathway_Homo sapiens_hsa043500.69861326
103ABC transporters_Homo sapiens_hsa020100.69200853
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69060315
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68944346
106Viral myocarditis_Homo sapiens_hsa054160.68164923
107Collecting duct acid secretion_Homo sapiens_hsa049660.67598958
108Serotonergic synapse_Homo sapiens_hsa047260.67521239
109Pyruvate metabolism_Homo sapiens_hsa006200.67498095
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66665600
111Ovarian steroidogenesis_Homo sapiens_hsa049130.66073080
112HIF-1 signaling pathway_Homo sapiens_hsa040660.65714353
113MicroRNAs in cancer_Homo sapiens_hsa052060.65155418
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.65033885
115Chronic myeloid leukemia_Homo sapiens_hsa052200.64686493
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63524445
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.63482397
118Thyroid hormone synthesis_Homo sapiens_hsa049180.63408182
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63140440
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.61963104
121Type II diabetes mellitus_Homo sapiens_hsa049300.61608727
122Ras signaling pathway_Homo sapiens_hsa040140.61417180
123Platelet activation_Homo sapiens_hsa046110.60439688
124Circadian rhythm_Homo sapiens_hsa047100.60299677
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59155549
126AMPK signaling pathway_Homo sapiens_hsa041520.57657089
127Endocytosis_Homo sapiens_hsa041440.56694612
128FoxO signaling pathway_Homo sapiens_hsa040680.56138323
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56134044
130Notch signaling pathway_Homo sapiens_hsa043300.55990727
131* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55863519
132* Pathways in cancer_Homo sapiens_hsa052000.55198509
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51538264
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.49254104
135Regulation of autophagy_Homo sapiens_hsa041400.49253896
136Thyroid cancer_Homo sapiens_hsa052160.48879111
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47099234
138Galactose metabolism_Homo sapiens_hsa000520.46422676
139N-Glycan biosynthesis_Homo sapiens_hsa005100.46087184
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45117680
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44293166
142Retinol metabolism_Homo sapiens_hsa008300.41961013
143Linoleic acid metabolism_Homo sapiens_hsa005910.40358625
144Peroxisome_Homo sapiens_hsa041460.35993946
145Lysine degradation_Homo sapiens_hsa003100.35731350
146Phototransduction_Homo sapiens_hsa047440.34845005
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32894827
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.32538370
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.31103858
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.31027225
151PPAR signaling pathway_Homo sapiens_hsa033200.30171404
152Choline metabolism in cancer_Homo sapiens_hsa052310.29373418
153Mineral absorption_Homo sapiens_hsa049780.28650416

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