WNT9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.23509987
2L-phenylalanine catabolic process (GO:0006559)7.23509987
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.01726955
4L-phenylalanine metabolic process (GO:0006558)7.01726955
5aromatic amino acid family catabolic process (GO:0009074)6.25628849
6glyoxylate metabolic process (GO:0046487)5.62001922
7kynurenine metabolic process (GO:0070189)5.57870304
8cysteine metabolic process (GO:0006534)5.49556255
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.43958186
10lysine metabolic process (GO:0006553)5.43410374
11lysine catabolic process (GO:0006554)5.43410374
12behavioral response to nicotine (GO:0035095)5.39705038
13indole-containing compound catabolic process (GO:0042436)5.37973287
14indolalkylamine catabolic process (GO:0046218)5.37973287
15tryptophan catabolic process (GO:0006569)5.37973287
16bile acid biosynthetic process (GO:0006699)5.25208614
17response to pheromone (GO:0019236)5.18167305
18urea cycle (GO:0000050)5.15244036
19urea metabolic process (GO:0019627)5.15244036
20tryptophan metabolic process (GO:0006568)5.13170091
21serine family amino acid catabolic process (GO:0009071)4.92778982
22homocysteine metabolic process (GO:0050667)4.88655975
23high-density lipoprotein particle remodeling (GO:0034375)4.80112315
24nitrogen cycle metabolic process (GO:0071941)4.66371581
25alpha-linolenic acid metabolic process (GO:0036109)4.65299648
26sulfur amino acid catabolic process (GO:0000098)4.57598940
27alpha-amino acid catabolic process (GO:1901606)4.47942724
28negative regulation of fibrinolysis (GO:0051918)4.45021543
29aromatic amino acid family metabolic process (GO:0009072)4.44988743
30regulation of triglyceride catabolic process (GO:0010896)4.43699822
31glutamate metabolic process (GO:0006536)4.42201169
32peptidyl-glutamic acid carboxylation (GO:0017187)4.37462024
33protein carboxylation (GO:0018214)4.37462024
34dicarboxylic acid biosynthetic process (GO:0043650)4.36130180
35bile acid metabolic process (GO:0008206)4.33626031
36regulation of protein activation cascade (GO:2000257)4.32310923
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.30797133
38complement activation, alternative pathway (GO:0006957)4.28730746
39regulation of fibrinolysis (GO:0051917)4.25521120
40short-chain fatty acid metabolic process (GO:0046459)4.23354349
41aspartate family amino acid catabolic process (GO:0009068)4.23146619
42cellular ketone body metabolic process (GO:0046950)4.22941753
43cellular modified amino acid catabolic process (GO:0042219)4.20261034
44tyrosine metabolic process (GO:0006570)4.19068159
45amino-acid betaine metabolic process (GO:0006577)4.15982505
46cellular amino acid catabolic process (GO:0009063)4.14211092
47reverse cholesterol transport (GO:0043691)4.07980766
48triglyceride homeostasis (GO:0070328)4.06794108
49acylglycerol homeostasis (GO:0055090)4.06794108
50drug catabolic process (GO:0042737)4.04998562
51negative regulation of sterol transport (GO:0032372)4.04756302
52negative regulation of cholesterol transport (GO:0032375)4.04756302
53plasma lipoprotein particle remodeling (GO:0034369)4.03212875
54protein-lipid complex remodeling (GO:0034368)4.03212875
55macromolecular complex remodeling (GO:0034367)4.03212875
56serine family amino acid metabolic process (GO:0009069)4.02366907
57regulation of complement activation (GO:0030449)4.01760179
58coenzyme catabolic process (GO:0009109)3.98739722
59drug transmembrane transport (GO:0006855)3.92834772
60L-fucose catabolic process (GO:0042355)3.91079129
61fucose catabolic process (GO:0019317)3.91079129
62L-fucose metabolic process (GO:0042354)3.91079129
63urate metabolic process (GO:0046415)3.89773019
64arginine metabolic process (GO:0006525)3.85499620
652-oxoglutarate metabolic process (GO:0006103)3.85094840
66glycine metabolic process (GO:0006544)3.84265815
67regulation of cholesterol esterification (GO:0010872)3.82829383
68indolalkylamine metabolic process (GO:0006586)3.81842984
69exogenous drug catabolic process (GO:0042738)3.81406680
70water-soluble vitamin biosynthetic process (GO:0042364)3.79391198
71DNA deamination (GO:0045006)3.79325669
72platelet dense granule organization (GO:0060155)3.72126567
73acetyl-CoA metabolic process (GO:0006084)3.69587838
74cellular glucuronidation (GO:0052695)3.68570920
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.63508927
76phospholipid efflux (GO:0033700)3.63208245
77benzene-containing compound metabolic process (GO:0042537)3.62810115
78regulation of cholesterol homeostasis (GO:2000188)3.61550448
79protein complex biogenesis (GO:0070271)3.61312477
80aldehyde catabolic process (GO:0046185)3.58453429
81ketone body metabolic process (GO:1902224)3.58205283
82serine family amino acid biosynthetic process (GO:0009070)3.57710147
83carboxylic acid catabolic process (GO:0046395)3.56810496
84organic acid catabolic process (GO:0016054)3.56810496
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56318267
86plasma lipoprotein particle clearance (GO:0034381)3.56095332
87NAD biosynthetic process (GO:0009435)3.52253139
88response to mercury ion (GO:0046689)3.48254053
89heme transport (GO:0015886)3.45844178
90positive regulation of lipid catabolic process (GO:0050996)3.45796591
91ethanol oxidation (GO:0006069)3.44453112
92mitochondrial respiratory chain complex I assembly (GO:0032981)3.43009527
93NADH dehydrogenase complex assembly (GO:0010257)3.43009527
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43009527
95imidazole-containing compound metabolic process (GO:0052803)3.42623995
96flavonoid metabolic process (GO:0009812)3.40549923
97pyridine nucleotide biosynthetic process (GO:0019363)3.39147824
98nicotinamide nucleotide biosynthetic process (GO:0019359)3.39147824
99epithelial cilium movement (GO:0003351)3.37513468
100mitochondrial respiratory chain complex assembly (GO:0033108)3.37290481
101amine catabolic process (GO:0009310)3.36613120
102cellular biogenic amine catabolic process (GO:0042402)3.36613120
103monocarboxylic acid catabolic process (GO:0072329)3.36070925
104phospholipid homeostasis (GO:0055091)3.34128312
105bile acid and bile salt transport (GO:0015721)3.33827493
106regulation of bile acid biosynthetic process (GO:0070857)3.33811546
107behavioral response to ethanol (GO:0048149)3.32250025
108negative regulation of telomere maintenance (GO:0032205)3.30475319
109negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29624824
110fatty acid beta-oxidation (GO:0006635)3.28398023
111uronic acid metabolic process (GO:0006063)3.27427359
112glucuronate metabolic process (GO:0019585)3.27427359
113fatty acid oxidation (GO:0019395)3.27003778
114drug transport (GO:0015893)3.26858167
115cholesterol efflux (GO:0033344)3.25918209
116negative regulation of lipase activity (GO:0060192)3.23151173
117fatty acid catabolic process (GO:0009062)3.20271132
118lipid oxidation (GO:0034440)3.20121555
119plasma lipoprotein particle assembly (GO:0034377)3.18872485
120piRNA metabolic process (GO:0034587)3.18048819
121protein-cofactor linkage (GO:0018065)3.13520944
122axoneme assembly (GO:0035082)3.10418777
123mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09544687
124energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08428561
125ATP synthesis coupled proton transport (GO:0015986)3.08428561
126preassembly of GPI anchor in ER membrane (GO:0016254)3.08015609
127respiratory chain complex IV assembly (GO:0008535)3.04690056
128detection of light stimulus involved in visual perception (GO:0050908)3.01581927
129detection of light stimulus involved in sensory perception (GO:0050962)3.01581927
130mannosylation (GO:0097502)3.00444009
131neuronal action potential (GO:0019228)2.92611783
132mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92177161
133kidney morphogenesis (GO:0060993)2.84668493
134protein polyglutamylation (GO:0018095)2.83034755
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81700431
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81700431
137cytochrome complex assembly (GO:0017004)2.80367409
138positive regulation of fatty acid transport (GO:2000193)2.78916001
139regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78743924
140rhodopsin mediated signaling pathway (GO:0016056)2.76381365
141cilium movement (GO:0003341)2.71749730
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.69684811
143indole-containing compound metabolic process (GO:0042430)2.69265512
144negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68810215
145negative regulation of mast cell activation (GO:0033004)2.68352352
146nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68265032
147transmission of nerve impulse (GO:0019226)2.67722239
148retinal cone cell development (GO:0046549)2.66447079
149neural tube formation (GO:0001841)2.63569861
150regulation of glucokinase activity (GO:0033131)2.61688160
151regulation of hexokinase activity (GO:1903299)2.61688160
152reflex (GO:0060004)2.61328186
153protein neddylation (GO:0045116)2.61321631
154gamma-aminobutyric acid transport (GO:0015812)2.60818539
155dopamine transport (GO:0015872)2.60335721
156cilium morphogenesis (GO:0060271)2.60170349
157regulation of cilium movement (GO:0003352)2.59996325
158photoreceptor cell maintenance (GO:0045494)2.58995721
159GPI anchor metabolic process (GO:0006505)2.57739095
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57074521
161ubiquinone biosynthetic process (GO:0006744)2.56655764
162nonmotile primary cilium assembly (GO:0035058)2.54878318
163photoreceptor cell development (GO:0042461)2.52274128
164electron transport chain (GO:0022900)2.51970718
165C4-dicarboxylate transport (GO:0015740)2.51253959
166rRNA catabolic process (GO:0016075)2.51123120
167regulation of action potential (GO:0098900)2.48319171
168ubiquinone metabolic process (GO:0006743)2.48147834
169reciprocal meiotic recombination (GO:0007131)2.47666922
170reciprocal DNA recombination (GO:0035825)2.47666922
171glycerophospholipid catabolic process (GO:0046475)2.47476833
172male meiosis I (GO:0007141)2.46960045
173startle response (GO:0001964)2.46009148
174cilium organization (GO:0044782)2.45963521
175multicellular organism reproduction (GO:0032504)2.45583755
176presynaptic membrane assembly (GO:0097105)2.42370449
177replication fork processing (GO:0031297)2.41329344
178respiratory electron transport chain (GO:0022904)2.41226578
179synaptic transmission, cholinergic (GO:0007271)2.41201416
180positive regulation of icosanoid secretion (GO:0032305)2.41179195
181protein localization to cilium (GO:0061512)2.41163141
182opioid receptor signaling pathway (GO:0038003)2.40886179
183L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40340782
184positive regulation of prostaglandin secretion (GO:0032308)2.38661806
185RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38567295
186adult feeding behavior (GO:0008343)2.38010876
187cellular response to ATP (GO:0071318)2.36740229
188phosphatidylinositol acyl-chain remodeling (GO:0036149)2.36690433
189pyrimidine nucleobase catabolic process (GO:0006208)2.34854032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.76509150
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.64158969
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.54650191
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.12964769
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.62234525
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.56752102
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.31541170
8ZNF274_21170338_ChIP-Seq_K562_Hela4.17439488
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.36088591
10VDR_22108803_ChIP-Seq_LS180_Human3.31593853
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.11501734
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56485256
13IGF1R_20145208_ChIP-Seq_DFB_Human2.47015093
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34520457
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28561290
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25408924
17FUS_26573619_Chip-Seq_HEK293_Human2.18420390
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16550650
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.15569805
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08138249
21EWS_26573619_Chip-Seq_HEK293_Human2.02271468
22P300_19829295_ChIP-Seq_ESCs_Human2.01646449
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.90366022
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85971523
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84505618
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80423503
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80257277
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.80224690
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78524157
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77804113
31ER_23166858_ChIP-Seq_MCF-7_Human1.76626544
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76100873
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70210803
34* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64566375
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61678775
36TP53_22573176_ChIP-Seq_HFKS_Human1.61140254
37MYC_18940864_ChIP-ChIP_HL60_Human1.60543719
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.59888004
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58840415
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57336266
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57279918
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57244197
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.57122887
44* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56332623
45* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56332623
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55773894
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51153680
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48906134
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46927492
50EZH2_22144423_ChIP-Seq_EOC_Human1.46491352
51IRF1_19129219_ChIP-ChIP_H3396_Human1.44562416
52AR_25329375_ChIP-Seq_VCAP_Human1.44551703
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44400018
54* EED_16625203_ChIP-ChIP_MESCs_Mouse1.43993305
55CLOCK_20551151_ChIP-Seq_293T_Human1.43155188
56NANOG_19829295_ChIP-Seq_ESCs_Human1.42961573
57SOX2_19829295_ChIP-Seq_ESCs_Human1.42961573
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42805836
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.42579774
60CBP_20019798_ChIP-Seq_JUKART_Human1.41415911
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41415911
62SMAD4_21799915_ChIP-Seq_A2780_Human1.41167476
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40162451
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39643480
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38782149
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.37808719
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37808719
68* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37181471
69* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36948198
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36345488
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.36213289
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36025983
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34193333
74STAT3_23295773_ChIP-Seq_U87_Human1.33480746
75TCF4_23295773_ChIP-Seq_U87_Human1.32513841
76* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32166945
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29747552
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29747552
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.29358377
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29049099
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.29013116
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27304326
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26557528
84* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26538404
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24671133
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.24513795
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24420517
88TCF4_22108803_ChIP-Seq_LS180_Human1.24374511
89* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24037434
90* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23068471
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.22528431
92RNF2_27304074_Chip-Seq_NSC_Mouse1.22482229
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22425117
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21166643
95AR_20517297_ChIP-Seq_VCAP_Human1.20976538
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20330647
97GATA3_21878914_ChIP-Seq_MCF-7_Human1.20308713
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17441651
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17214033
100HTT_18923047_ChIP-ChIP_STHdh_Human1.15755388
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15740627
102* EZH2_27294783_Chip-Seq_ESCs_Mouse1.14783463
103NCOR_22424771_ChIP-Seq_293T_Human1.14035883
104HNF4A_19822575_ChIP-Seq_HepG2_Human1.13484955
105* RUNX2_22187159_ChIP-Seq_PCA_Human1.13434969
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13199495
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12064607
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.11029223
109LXR_22292898_ChIP-Seq_THP-1_Human1.10209820
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09334602
111CTCF_27219007_Chip-Seq_Bcells_Human1.08893781
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07323604
113HOXB7_26014856_ChIP-Seq_BT474_Human1.07234397
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06619001
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06103301
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05641824
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.05266144
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.05146512
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.04698498
120ELK1_19687146_ChIP-ChIP_HELA_Human1.04539744
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03841308
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.03837132
123VDR_23849224_ChIP-Seq_CD4+_Human1.02626805
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02614802
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00647552
126P53_22387025_ChIP-Seq_ESCs_Mouse1.00350239
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99062114
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99025083
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98899183
130AR_21572438_ChIP-Seq_LNCaP_Human0.97480243
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.96664937
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96619050
133DROSHA_22980978_ChIP-Seq_HELA_Human0.96553615
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96028646
135GATA1_22025678_ChIP-Seq_K562_Human0.94997874
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94825202
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94185902
138TAF15_26573619_Chip-Seq_HEK293_Human0.93780789
139* TP53_20018659_ChIP-ChIP_R1E_Mouse0.88333936
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.87307222
141GBX2_23144817_ChIP-Seq_PC3_Human0.85929893
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84763813
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83606463
144* RNF2_27304074_Chip-Seq_ESCs_Mouse0.83294185
145BCAT_22108803_ChIP-Seq_LS180_Human0.82243641
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82042105
147RING1B_27294783_Chip-Seq_ESCs_Mouse0.81114942
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.81090498
149REST_18959480_ChIP-ChIP_MESCs_Mouse0.80819815
150* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78372458
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76025307
152REST_21632747_ChIP-Seq_MESCs_Mouse0.75453086
153CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75088977
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.74572073
155RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74260163
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73006393
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.72967474
158AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71999825
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71911298
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70737968
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.70337131
162ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68943006
163TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68678865
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.67910014
165EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.66952314
166RXRA_24833708_ChIP-Seq_LIVER_Mouse0.66039856
167CREB1_26743006_Chip-Seq_LNCaP_Human0.65452284
168CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.65343222
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.64440886
170TAF2_19829295_ChIP-Seq_ESCs_Human0.63697249
171* AR_19668381_ChIP-Seq_PC3_Human0.62917997
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.62673983
173GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62557113
174CBP_21632823_ChIP-Seq_H3396_Human0.62271611
175BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61758521
176STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.61712581
177SOX2_27498859_Chip-Seq_STOMACH_Mouse0.60468372
178KDM2B_26808549_Chip-Seq_K562_Human0.60205822
179ZNF263_19887448_ChIP-Seq_K562_Human0.59347250
180SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57154225
181* RING1B_27294783_Chip-Seq_NPCs_Mouse0.56984317
182MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.56383413
183CBX2_27304074_Chip-Seq_ESCs_Mouse0.55662850
184WT1_25993318_ChIP-Seq_PODOCYTE_Human0.55287613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.48036416
2MP0002139_abnormal_hepatobiliary_system7.13801177
3MP0005085_abnormal_gallbladder_physiolo5.64357121
4MP0005365_abnormal_bile_salt5.23174972
5MP0008875_abnormal_xenobiotic_pharmacok4.81616954
6MP0003252_abnormal_bile_duct3.53839303
7MP0010329_abnormal_lipoprotein_level3.17596277
8MP0005332_abnormal_amino_acid3.07849305
9MP0005083_abnormal_biliary_tract2.83954154
10MP0003195_calcinosis2.60732177
11MP0006072_abnormal_retinal_apoptosis2.57785151
12MP0008877_abnormal_DNA_methylation2.55782355
13MP0002102_abnormal_ear_morphology2.53502692
14MP0003806_abnormal_nucleotide_metabolis2.48888666
15MP0009840_abnormal_foam_cell2.42355266
16MP0004019_abnormal_vitamin_homeostasis2.40852082
17MP0001666_abnormal_nutrient_absorption2.29488557
18MP0003136_yellow_coat_color2.25091643
19MP0005645_abnormal_hypothalamus_physiol2.21188625
20MP0003787_abnormal_imprinting2.21008601
21MP0006292_abnormal_olfactory_placode2.15576906
22MP0005646_abnormal_pituitary_gland2.13815518
23MP0003011_delayed_dark_adaptation2.07835880
24MP0000372_irregular_coat_pigmentation2.07769135
25MP0003880_abnormal_central_pattern2.07446204
26MP0005253_abnormal_eye_physiology2.03000339
27MP0002876_abnormal_thyroid_physiology2.00801096
28MP0005451_abnormal_body_composition2.00746779
29MP0001986_abnormal_taste_sensitivity1.96229313
30MP0002638_abnormal_pupillary_reflex1.93362396
31MP0004885_abnormal_endolymph1.87952049
32MP0002138_abnormal_hepatobiliary_system1.83653443
33MP0002118_abnormal_lipid_homeostasis1.81134514
34MP0002938_white_spotting1.79671871
35MP0002736_abnormal_nociception_after1.79454533
36MP0004043_abnormal_pH_regulation1.76574084
37MP0003646_muscle_fatigue1.76546405
38MP0004133_heterotaxia1.73557385
39MP0002272_abnormal_nervous_system1.73139728
40MP0003191_abnormal_cellular_cholesterol1.66956386
41MP0000631_abnormal_neuroendocrine_gland1.66338603
42MP0004142_abnormal_muscle_tone1.64039860
43MP0001485_abnormal_pinna_reflex1.61418281
44MP0002163_abnormal_gland_morphology1.57053581
45MP0000609_abnormal_liver_physiology1.56990441
46MP0005319_abnormal_enzyme/_coenzyme1.53430327
47MP0002653_abnormal_ependyma_morphology1.50861339
48MP0010368_abnormal_lymphatic_system1.50732318
49MP0000427_abnormal_hair_cycle1.43152355
50MP0001486_abnormal_startle_reflex1.43127141
51MP0002837_dystrophic_cardiac_calcinosis1.39962003
52MP0009643_abnormal_urine_homeostasis1.39454846
53MP0001764_abnormal_homeostasis1.38106933
54MP0005584_abnormal_enzyme/coenzyme_acti1.36985905
55MP0005174_abnormal_tail_pigmentation1.36977192
56MP0005379_endocrine/exocrine_gland_phen1.35095210
57MP0003705_abnormal_hypodermis_morpholog1.31267041
58MP0005389_reproductive_system_phenotype1.30838002
59MP0002735_abnormal_chemical_nociception1.30793662
60MP0002160_abnormal_reproductive_system1.29771961
61MP0004145_abnormal_muscle_electrophysio1.26865542
62MP0005075_abnormal_melanosome_morpholog1.26456618
63MP0003283_abnormal_digestive_organ1.25907984
64MP0002572_abnormal_emotion/affect_behav1.25222700
65MP0002277_abnormal_respiratory_mucosa1.23307810
66MP0002095_abnormal_skin_pigmentation1.22851216
67MP0003868_abnormal_feces_composition1.22823432
68MP0001984_abnormal_olfaction1.22504165
69MP0002733_abnormal_thermal_nociception1.22038226
70MP0002557_abnormal_social/conspecific_i1.20981126
71MP0001970_abnormal_pain_threshold1.18238443
72MP0005195_abnormal_posterior_eye1.17865037
73MP0003329_amyloid_beta_deposits1.15985932
74MP0001529_abnormal_vocalization1.15756436
75MP0002234_abnormal_pharynx_morphology1.14966983
76MP0008995_early_reproductive_senescence1.13902375
77MP0001919_abnormal_reproductive_system1.13351464
78MP0009053_abnormal_anal_canal1.12018063
79MP0000569_abnormal_digit_pigmentation1.12003992
80MP0005636_abnormal_mineral_homeostasis1.11410231
81MP0005551_abnormal_eye_electrophysiolog1.07852862
82MP0001756_abnormal_urination1.04437818
83MP0003121_genomic_imprinting1.00365559
84MP0005187_abnormal_penis_morphology0.99452253
85MP0004215_abnormal_myocardial_fiber0.99265064
86MP0003890_abnormal_embryonic-extraembry0.99259556
87MP0000383_abnormal_hair_follicle0.98948748
88MP0002063_abnormal_learning/memory/cond0.98726505
89MP0003123_paternal_imprinting0.97147725
90MP0006036_abnormal_mitochondrial_physio0.96309924
91MP0010386_abnormal_urinary_bladder0.94909759
92MP0002752_abnormal_somatic_nervous0.94660448
93MP0001324_abnormal_eye_pigmentation0.94655721
94MP0000604_amyloidosis0.92464108
95MP0004130_abnormal_muscle_cell0.91989596
96MP0005377_hearing/vestibular/ear_phenot0.91392828
97MP0003878_abnormal_ear_physiology0.91392828
98MP0004742_abnormal_vestibular_system0.90790163
99MP0000026_abnormal_inner_ear0.90710671
100MP0002229_neurodegeneration0.89057379
101MP0001963_abnormal_hearing_physiology0.88866912
102MP0000015_abnormal_ear_pigmentation0.87192109
103MP0008058_abnormal_DNA_repair0.87012745
104MP0005535_abnormal_body_temperature0.86931573
105MP0001905_abnormal_dopamine_level0.86296071
106MP0009780_abnormal_chondrocyte_physiolo0.85996805
107MP0003718_maternal_effect0.84317739
108MP0002734_abnormal_mechanical_nocicepti0.83124629
109MP0000751_myopathy0.82253124
110MP0000598_abnormal_liver_morphology0.81608801
111MP0005410_abnormal_fertilization0.79882844
112MP0002184_abnormal_innervation0.79444825
113MP0002751_abnormal_autonomic_nervous0.78234337
114MP0001765_abnormal_ion_homeostasis0.77980379
115MP0002693_abnormal_pancreas_physiology0.77335968
116MP0000778_abnormal_nervous_system0.77096562
117MP0010234_abnormal_vibrissa_follicle0.75838196
118MP0005220_abnormal_exocrine_pancreas0.75171641
119MP0006276_abnormal_autonomic_nervous0.74705642
120MP0008872_abnormal_physiological_respon0.73370070
121MP0003186_abnormal_redox_activity0.73105189
122MP0003638_abnormal_response/metabolism_0.72357976
123MP0005670_abnormal_white_adipose0.70637934
124MP0009642_abnormal_blood_homeostasis0.70047230
125MP0002078_abnormal_glucose_homeostasis0.69982895
126MP0000639_abnormal_adrenal_gland0.68034056
127MP0009046_muscle_twitch0.67468344
128MP0005330_cardiomyopathy0.66153782
129MP0008874_decreased_physiological_sensi0.66106718
130MP0009764_decreased_sensitivity_to0.65451639
131MP0005167_abnormal_blood-brain_barrier0.65329784
132MP0005376_homeostasis/metabolism_phenot0.64728419
133MP0009745_abnormal_behavioral_response0.64369453
134MP0004272_abnormal_basement_membrane0.63841092
135MP0002822_catalepsy0.63737091
136MP0003635_abnormal_synaptic_transmissio0.63335425
137MP0002136_abnormal_kidney_physiology0.62670389
138MP0000230_abnormal_systemic_arterial0.62640910
139MP0002064_seizures0.61380199
140MP0008961_abnormal_basal_metabolism0.61084564
141MP0006035_abnormal_mitochondrial_morpho0.60399065
142MP0005266_abnormal_metabolism0.60112687
143MP0002971_abnormal_brown_adipose0.59868229
144MP0009763_increased_sensitivity_to0.59495393
145MP0001501_abnormal_sleep_pattern0.59323088
146MP0009697_abnormal_copulation0.59006277
147MP0003690_abnormal_glial_cell0.57920174
148MP0003656_abnormal_erythrocyte_physiolo0.56129564
149MP0009672_abnormal_birth_weight0.55126176
150MP0005448_abnormal_energy_balance0.52113236
151MP0006138_congestive_heart_failure0.51475609
152MP0002067_abnormal_sensory_capabilities0.51037217
153MP0002909_abnormal_adrenal_gland0.50254631
154MP0001968_abnormal_touch/_nociception0.49979432
155MP0003122_maternal_imprinting0.49842506
156MP0003075_altered_response_to0.49782453
157MP0004859_abnormal_synaptic_plasticity0.49627392
158MP0003137_abnormal_impulse_conducting0.48492070
159MP0005248_abnormal_Harderian_gland0.47729168
160MP0002928_abnormal_bile_duct0.47623318
161MP0002069_abnormal_eating/drinking_beha0.45989644
162MP0000579_abnormal_nail_morphology0.45782074
163MP0005084_abnormal_gallbladder_morpholo0.45355728
164MP0002090_abnormal_vision0.45003071
165MP0009384_cardiac_valve_regurgitation0.44157314
166MP0010030_abnormal_orbit_morphology0.43104879
167MP0004924_abnormal_behavior0.43086257
168MP0005386_behavior/neurological_phenoty0.43086257
169MP0002332_abnormal_exercise_endurance0.42789780
170MP0004147_increased_porphyrin_level0.42616446
171MP0004036_abnormal_muscle_relaxation0.42048980

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.49686042
2Deep venous thrombosis (HP:0002625)6.17092781
3Intrahepatic cholestasis (HP:0001406)5.72004127
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.51683807
5Xanthomatosis (HP:0000991)5.37399802
6Hypobetalipoproteinemia (HP:0003563)5.32080267
7Hyperlipoproteinemia (HP:0010980)4.91889449
8Prolonged partial thromboplastin time (HP:0003645)4.70605332
9Hyperammonemia (HP:0001987)4.39682729
10Ketosis (HP:0001946)4.29074722
11Pancreatic cysts (HP:0001737)4.28616108
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.24518123
13Hyperglycinemia (HP:0002154)4.16775554
14Congenital stationary night blindness (HP:0007642)4.08188049
15Hyperglycinuria (HP:0003108)4.06414800
16Complement deficiency (HP:0004431)3.96006816
17Hypolipoproteinemia (HP:0010981)3.92453713
18Gout (HP:0001997)3.91640895
19Abnormality of midbrain morphology (HP:0002418)3.87154429
20Molar tooth sign on MRI (HP:0002419)3.87154429
21Abnormality of glycine metabolism (HP:0010895)3.85797202
22Abnormality of serine family amino acid metabolism (HP:0010894)3.85797202
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.84285949
24Pancreatic fibrosis (HP:0100732)3.83459588
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.79882447
26Joint hemorrhage (HP:0005261)3.72473561
27True hermaphroditism (HP:0010459)3.71318669
28Nephronophthisis (HP:0000090)3.67492550
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.48413319
30Epidermoid cyst (HP:0200040)3.47547256
31Hypoalphalipoproteinemia (HP:0003233)3.45797016
32Ketoacidosis (HP:0001993)3.44200154
33Abnormality of methionine metabolism (HP:0010901)3.42779349
34Abnormality of fatty-acid metabolism (HP:0004359)3.35134058
35Abnormality of the renal medulla (HP:0100957)3.27352491
36Abnormality of the common coagulation pathway (HP:0010990)3.24993280
37Type II lissencephaly (HP:0007260)3.22544840
38Abnormality of the renal cortex (HP:0011035)3.21076851
39Attenuation of retinal blood vessels (HP:0007843)3.15947081
40Delayed CNS myelination (HP:0002188)3.13614384
41Hypoglycemic coma (HP:0001325)3.09571806
42Abnormality of pyrimidine metabolism (HP:0004353)3.09314943
43Fat malabsorption (HP:0002630)3.06875382
44Abnormality of nucleobase metabolism (HP:0010932)3.04636902
45Tubular atrophy (HP:0000092)3.03436351
46Abnormality of purine metabolism (HP:0004352)3.02297882
47Cerebral edema (HP:0002181)3.00651362
48Abolished electroretinogram (ERG) (HP:0000550)2.88932456
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88931090
50Medial flaring of the eyebrow (HP:0010747)2.88762431
51Abnormal gallbladder physiology (HP:0012438)2.87965373
52Cholecystitis (HP:0001082)2.87965373
53Abnormal rod and cone electroretinograms (HP:0008323)2.85036855
54Hypercholesterolemia (HP:0003124)2.80792281
55Neonatal onset (HP:0003623)2.80065633
56Hyperbilirubinemia (HP:0002904)2.78176220
57Abnormal drinking behavior (HP:0030082)2.77282713
58Polydipsia (HP:0001959)2.77282713
59Lethargy (HP:0001254)2.76866703
60Hepatocellular carcinoma (HP:0001402)2.75061722
61Spastic diplegia (HP:0001264)2.73922106
62Abnormality of complement system (HP:0005339)2.72709413
63Cholelithiasis (HP:0001081)2.70267423
64Increased purine levels (HP:0004368)2.69553075
65Hyperuricemia (HP:0002149)2.69553075
66Acute necrotizing encephalopathy (HP:0006965)2.66933558
67Pendular nystagmus (HP:0012043)2.66906949
68Alkalosis (HP:0001948)2.65096111
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63547090
70Cystic liver disease (HP:0006706)2.62563738
71Metabolic acidosis (HP:0001942)2.61504622
72Abnormality of the intrinsic pathway (HP:0010989)2.60342672
73Skin nodule (HP:0200036)2.59168401
74Abnormal gallbladder morphology (HP:0012437)2.57833490
75Status epilepticus (HP:0002133)2.57604056
76Enlarged kidneys (HP:0000105)2.55905109
77Abnormality of serum amino acid levels (HP:0003112)2.52556257
78Increased corneal curvature (HP:0100692)2.51755320
79Keratoconus (HP:0000563)2.51755320
80Mitochondrial inheritance (HP:0001427)2.51062895
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50652075
82Dicarboxylic aciduria (HP:0003215)2.50652075
83Conjugated hyperbilirubinemia (HP:0002908)2.49157457
84Large for gestational age (HP:0001520)2.48788440
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48444933
86Increased circulating renin level (HP:0000848)2.48042834
87Chorioretinal atrophy (HP:0000533)2.46154118
88Vomiting (HP:0002013)2.43752001
893-Methylglutaconic aciduria (HP:0003535)2.42809485
90Increased CSF lactate (HP:0002490)2.42652861
91Decreased central vision (HP:0007663)2.42387057
92Progressive macrocephaly (HP:0004481)2.37606035
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36409498
94Hypothermia (HP:0002045)2.36339573
95Renal cortical cysts (HP:0000803)2.35913173
96Optic nerve hypoplasia (HP:0000609)2.34045284
97Lissencephaly (HP:0001339)2.32791016
98Hypochromic microcytic anemia (HP:0004840)2.32419127
99Spontaneous abortion (HP:0005268)2.31673358
100Focal motor seizures (HP:0011153)2.31591452
101Optic disc pallor (HP:0000543)2.29938821
102Inability to walk (HP:0002540)2.29584961
103Proximal tubulopathy (HP:0000114)2.28490645
104Sclerocornea (HP:0000647)2.26873792
105Irritability (HP:0000737)2.25909578
106Abnormality of the gallbladder (HP:0005264)2.24421296
107Chronic hepatic failure (HP:0100626)2.23502704
108Abnormal mitochondria in muscle tissue (HP:0008316)2.23181999
109Sensorimotor neuropathy (HP:0007141)2.21841939
110Thyroid-stimulating hormone excess (HP:0002925)2.19908729
111Polyuria (HP:0000103)2.19578373
112Steatorrhea (HP:0002570)2.17976887
113Congenital hepatic fibrosis (HP:0002612)2.17397157
114Esophageal varix (HP:0002040)2.16409946
115Malnutrition (HP:0004395)2.15668830
116Confusion (HP:0001289)2.13380339
117Acute encephalopathy (HP:0006846)2.11010293
118Cerebellar dysplasia (HP:0007033)2.10739407
119Gaze-evoked nystagmus (HP:0000640)2.09808428
120Abnormal respiratory epithelium morphology (HP:0012253)2.07832275
121Abnormal respiratory motile cilium morphology (HP:0005938)2.07832275
122Nephrolithiasis (HP:0000787)2.06286070
123Hypoplasia of the fovea (HP:0007750)2.05272016
124Aplasia/Hypoplasia of the fovea (HP:0008060)2.05272016
125Gait imbalance (HP:0002141)2.04885246
126Dynein arm defect of respiratory motile cilia (HP:0012255)2.04456914
127Absent/shortened dynein arms (HP:0200106)2.04456914
128Abnormality of alanine metabolism (HP:0010916)2.03220714
129Hyperalaninemia (HP:0003348)2.03220714
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03220714
131Generalized aminoaciduria (HP:0002909)2.03213830
132Anencephaly (HP:0002323)2.03194982
133Vascular calcification (HP:0004934)2.03186454
134Hepatocellular necrosis (HP:0001404)2.02286885
135Bile duct proliferation (HP:0001408)2.02005376
136Abnormal biliary tract physiology (HP:0012439)2.02005376
137Congenital, generalized hypertrichosis (HP:0004540)2.01977069
138Hepatic necrosis (HP:0002605)2.01824261
139Broad-based gait (HP:0002136)2.01785442
140Furrowed tongue (HP:0000221)2.00705836
141Abnormality of the labia minora (HP:0012880)1.99660395
142Hypokalemic alkalosis (HP:0001949)1.98942966
143Hyperventilation (HP:0002883)1.98941458
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.98356083
145Progressive inability to walk (HP:0002505)1.97991632
146Congenital primary aphakia (HP:0007707)1.97730757
147Colon cancer (HP:0003003)1.96936415
148Glycosuria (HP:0003076)1.95685070
149Abnormality of urine glucose concentration (HP:0011016)1.95685070
150Nephrogenic diabetes insipidus (HP:0009806)1.95390756
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.94589941
152Male pseudohermaphroditism (HP:0000037)1.93081664
153Stomach cancer (HP:0012126)1.91856789
154Intestinal atresia (HP:0011100)1.91503552
155Concave nail (HP:0001598)1.89444317
156Pachygyria (HP:0001302)1.88505546
157Hemiparesis (HP:0001269)1.88049253
158Rickets (HP:0002748)1.87974326
159Hypomagnesemia (HP:0002917)1.86979421
160Septo-optic dysplasia (HP:0100842)1.86848722
161Aplasia/hypoplasia of the uterus (HP:0008684)1.86366798
162Asplenia (HP:0001746)1.85090120
163Severe muscular hypotonia (HP:0006829)1.84861161
164Lipid accumulation in hepatocytes (HP:0006561)1.84757109
165Amyloidosis (HP:0011034)1.83760303
166Abnormal ciliary motility (HP:0012262)1.83574784
167Myoglobinuria (HP:0002913)1.82978495
168Increased hepatocellular lipid droplets (HP:0006565)1.81844618
169Febrile seizures (HP:0002373)1.81592216
170Cardiovascular calcification (HP:0011915)1.80746847
171Bony spicule pigmentary retinopathy (HP:0007737)1.79900567
172Abnormality of the pons (HP:0007361)1.79853080
173Metabolic alkalosis (HP:0200114)1.78815788
174Hypophosphatemic rickets (HP:0004912)1.78734150
175Pseudobulbar signs (HP:0002200)1.77836994
176Reticulocytosis (HP:0001923)1.77817546
177Genital tract atresia (HP:0001827)1.77643732
178Agitation (HP:0000713)1.77553990
179Abnormal urine output (HP:0012590)1.76615628
180Late onset (HP:0003584)1.76393029
181Turricephaly (HP:0000262)1.76234249
182Hypoplasia of the pons (HP:0012110)1.75961559
183Mitral stenosis (HP:0001718)1.75468754
184Hydroxyprolinuria (HP:0003080)1.75277459
185Abnormality of proline metabolism (HP:0010907)1.75277459
186Aplasia/Hypoplasia of the tibia (HP:0005772)1.74134909
187Focal seizures (HP:0007359)1.74077481
188Vaginal atresia (HP:0000148)1.74002197
189Glomerulosclerosis (HP:0000096)1.73886600
190Abnormal number of erythroid precursors (HP:0012131)1.72903612
191Lymphangioma (HP:0100764)1.72436200
192Postaxial foot polydactyly (HP:0001830)1.71742021
193Abnormality of the Achilles tendon (HP:0005109)1.70095963
194Cerebral hemorrhage (HP:0001342)1.68448457
195Thrombophlebitis (HP:0004418)1.67166571
196Facial shape deformation (HP:0011334)1.66607314
197Potter facies (HP:0002009)1.66607314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.98202034
2ADRBK23.70718577
3WNK43.35345959
4MAP3K93.29955189
5MAP2K42.94655614
6MAP4K22.84450377
7ZAK2.63974022
8NUAK12.51541604
9BMPR1B2.47634580
10DAPK22.44432913
11PKN22.38830901
12GRK12.37842145
13WNK32.37835854
14SIK12.27247419
15ERN12.14237645
16STK38L2.13005390
17LATS12.05529237
18ACVR1B2.02878577
19LATS21.99168821
20STK381.94909307
21TLK11.92937762
22OXSR11.91497499
23FGFR41.84661232
24EPHA41.81402734
25TIE11.78920611
26PTK61.71269207
27KSR21.70686688
28MAPK131.67625060
29ERBB41.66838828
30TRIB31.55335627
31TXK1.51218771
32NTRK31.50061718
33MST1R1.49069141
34MAP3K71.44706217
35RIPK11.40302266
36ADRBK11.33465682
37TNIK1.28686373
38MAP2K31.26258076
39MAP3K41.25230414
40INSRR1.24263139
41MUSK1.23294505
42MAP3K101.19738082
43LMTK21.19658984
44DYRK21.15199549
45MST41.13918723
46MINK11.13393478
47CAMKK21.12043147
48PLK21.07323830
49NTRK21.06813640
50PNCK1.06302705
51MAP3K131.06282762
52PAK31.05516300
53TRIM281.04591738
54NTRK11.04164831
55TAOK31.03616846
56EPHB21.03165619
57BRSK21.03013672
58MARK11.01385156
59ERBB20.98944712
60TAF10.98918183
61PRKCE0.97548809
62PRKCH0.97535363
63CSNK1G10.97007029
64FRK0.94448425
65MKNK20.91762701
66CSNK1G20.90775199
67WNK10.89606877
68STK160.89344117
69PRKAA20.88873771
70CSNK1G30.88420465
71SGK4940.87258814
72SGK2230.87258814
73MAP3K110.86428118
74KSR10.86168096
75TTN0.85877313
76FER0.84221978
77PLK40.84149572
78PRKCZ0.83560552
79VRK10.83320398
80VRK20.81679422
81FGFR20.81267573
82NEK10.80278610
83ABL20.79836389
84STK390.79245784
85SIK20.78809605
86BMX0.78449876
87WEE10.75827961
88PRKCG0.75103225
89PLK30.72479433
90ICK0.71315858
91TGFBR10.69041839
92MAPK110.68890150
93BCR0.68819014
94PRKACG0.68454018
95SGK30.68247089
96CSNK1A1L0.67797015
97PIK3CA0.67102703
98DAPK10.66127869
99SGK20.65615206
100CAMK2G0.65528855
101PTK20.65484727
102JAK20.64552014
103MYLK0.64055564
104MAP2K60.63539064
105MAP2K10.62759603
106GRK60.61674051
107IRAK10.61506608
108MAPK120.61270639
109MAPKAPK50.61243785
110PINK10.61184296
111CAMK2A0.61097759
112PHKG20.61029712
113PHKG10.61029712
114MAPKAPK30.60759101
115MKNK10.60404403
116TEC0.58655575
117NME10.58562480
118PTK2B0.58335973
119PASK0.56877371
120IRAK20.56499016
121CDK190.56269305
122NLK0.56128427
123FES0.55493063
124MAPK150.55430423
125CAMK40.55285316
126PRKCQ0.54103493
127PRKCI0.53352994
128FGFR10.52535746
129PKN10.52069264
130GRK70.52009002
131SGK10.51949628
132PDPK10.51870855
133PRKAA10.51684559
134MAP2K70.51044714
135PRKACA0.50703478
136CAMKK10.49470679
137DAPK30.49205353
138ERBB30.48255311
139MAP3K10.48004926
140CSNK1E0.47868855
141KDR0.46863729
142PDK40.46695551
143PDK30.46695551
144RET0.46407948
145IKBKB0.46163351
146CAMK10.45564183
147IRAK40.44658276
148PDGFRA0.44507048
149CASK0.43074335
150CDK50.43029868
151RPS6KA50.42820452
152STK30.42582456
153RPS6KA30.42545277
154PAK60.42319292
155CDK30.42161351
156DYRK1B0.41250607
157ITK0.40968541
158CSNK1A10.40914889
159STK110.40336101
160ARAF0.40212859
161EIF2AK30.39612389
162AKT30.39062928
163PIK3CG0.38250422
164KIT0.38085112
165PLK10.37099561
166PRKCA0.36917122
167OBSCN0.35785819
168TRPM70.35719613
169CAMK2D0.31848366
170TSSK60.30668844

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.07284364
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.98693896
3Nitrogen metabolism_Homo sapiens_hsa009103.36103499
4Arginine biosynthesis_Homo sapiens_hsa002203.16331585
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14358192
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68965785
7Tryptophan metabolism_Homo sapiens_hsa003802.55539098
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49675786
9Fatty acid degradation_Homo sapiens_hsa000712.44222952
10Linoleic acid metabolism_Homo sapiens_hsa005912.42504144
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40888745
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40013994
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39319255
14Butanoate metabolism_Homo sapiens_hsa006502.38413488
15Propanoate metabolism_Homo sapiens_hsa006402.26788570
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25115077
17Protein export_Homo sapiens_hsa030602.20835811
18Complement and coagulation cascades_Homo sapiens_hsa046102.13240551
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12540916
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97357889
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88352633
22Peroxisome_Homo sapiens_hsa041461.84572555
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78766109
24Bile secretion_Homo sapiens_hsa049761.77576273
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73082873
26PPAR signaling pathway_Homo sapiens_hsa033201.73007985
27Fatty acid metabolism_Homo sapiens_hsa012121.72856189
28Phenylalanine metabolism_Homo sapiens_hsa003601.70866313
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68318858
30Homologous recombination_Homo sapiens_hsa034401.67376379
31beta-Alanine metabolism_Homo sapiens_hsa004101.67036173
32Ether lipid metabolism_Homo sapiens_hsa005651.63778946
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63252316
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62702596
35Pyruvate metabolism_Homo sapiens_hsa006201.62042168
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59413653
37RNA polymerase_Homo sapiens_hsa030201.58720235
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.56073043
39Fanconi anemia pathway_Homo sapiens_hsa034601.54821008
40Basal transcription factors_Homo sapiens_hsa030221.54670046
41Chemical carcinogenesis_Homo sapiens_hsa052041.54543731
42Carbon metabolism_Homo sapiens_hsa012001.54058063
43Histidine metabolism_Homo sapiens_hsa003401.53527563
44Biosynthesis of amino acids_Homo sapiens_hsa012301.51596091
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50897888
46Proteasome_Homo sapiens_hsa030501.46938347
47Huntingtons disease_Homo sapiens_hsa050161.45443444
48Retinol metabolism_Homo sapiens_hsa008301.41307406
49Caffeine metabolism_Homo sapiens_hsa002321.37660077
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.37270032
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.35509198
52Olfactory transduction_Homo sapiens_hsa047401.32588284
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31349495
54Tyrosine metabolism_Homo sapiens_hsa003501.29696061
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29373356
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.20147815
57Starch and sucrose metabolism_Homo sapiens_hsa005001.20091525
58Ribosome_Homo sapiens_hsa030101.17522397
59RNA degradation_Homo sapiens_hsa030181.17488640
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13432440
61Selenocompound metabolism_Homo sapiens_hsa004501.13280686
62Fatty acid elongation_Homo sapiens_hsa000621.12040727
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10041505
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09604211
65Sulfur metabolism_Homo sapiens_hsa009201.09601193
66Arachidonic acid metabolism_Homo sapiens_hsa005901.08271371
67Staphylococcus aureus infection_Homo sapiens_hsa051501.05678509
68Fat digestion and absorption_Homo sapiens_hsa049751.02745009
69ABC transporters_Homo sapiens_hsa020100.99346895
70Regulation of autophagy_Homo sapiens_hsa041400.98405127
71Collecting duct acid secretion_Homo sapiens_hsa049660.95474472
72Insulin secretion_Homo sapiens_hsa049110.87630239
73Lysine degradation_Homo sapiens_hsa003100.87462016
74Vitamin digestion and absorption_Homo sapiens_hsa049770.84277914
75Arginine and proline metabolism_Homo sapiens_hsa003300.83446486
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.82764570
77Serotonergic synapse_Homo sapiens_hsa047260.80414837
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78192893
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77092056
80Ovarian steroidogenesis_Homo sapiens_hsa049130.76102843
81Vitamin B6 metabolism_Homo sapiens_hsa007500.75192538
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74727171
83Steroid biosynthesis_Homo sapiens_hsa001000.74147820
84Purine metabolism_Homo sapiens_hsa002300.73558635
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72392134
86Folate biosynthesis_Homo sapiens_hsa007900.70523649
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70069809
88Glycerolipid metabolism_Homo sapiens_hsa005610.66307246
89Sulfur relay system_Homo sapiens_hsa041220.66261825
90Type I diabetes mellitus_Homo sapiens_hsa049400.65956052
91Salivary secretion_Homo sapiens_hsa049700.64922871
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.64520791
93Pentose phosphate pathway_Homo sapiens_hsa000300.63753874
94Nicotine addiction_Homo sapiens_hsa050330.63717387
95Fructose and mannose metabolism_Homo sapiens_hsa000510.58026586
96Calcium signaling pathway_Homo sapiens_hsa040200.56012646
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54189195
98Asthma_Homo sapiens_hsa053100.51833739
99Glutathione metabolism_Homo sapiens_hsa004800.50204093
100Pyrimidine metabolism_Homo sapiens_hsa002400.50096640
101Mineral absorption_Homo sapiens_hsa049780.48199329
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44821354
103GABAergic synapse_Homo sapiens_hsa047270.44473559
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44031651
105Metabolic pathways_Homo sapiens_hsa011000.42661086
106Graft-versus-host disease_Homo sapiens_hsa053320.40773878
107Dopaminergic synapse_Homo sapiens_hsa047280.39248531
108Primary immunodeficiency_Homo sapiens_hsa053400.35020425
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34658235
110Allograft rejection_Homo sapiens_hsa053300.33698726
111Non-homologous end-joining_Homo sapiens_hsa034500.32926919
112Prion diseases_Homo sapiens_hsa050200.31950260
113Oxidative phosphorylation_Homo sapiens_hsa001900.30586613
114Rheumatoid arthritis_Homo sapiens_hsa053230.29949838
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28229707
116Cardiac muscle contraction_Homo sapiens_hsa042600.27548807
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27101458
118Synaptic vesicle cycle_Homo sapiens_hsa047210.25407951
119One carbon pool by folate_Homo sapiens_hsa006700.25013224
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24337110
121Fatty acid biosynthesis_Homo sapiens_hsa000610.23524236
122Glucagon signaling pathway_Homo sapiens_hsa049220.23441218
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23150243
124Insulin resistance_Homo sapiens_hsa049310.21917921
125Galactose metabolism_Homo sapiens_hsa000520.21396522
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20436075
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.17520750
128Phototransduction_Homo sapiens_hsa047440.15076097
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14888229
130Parkinsons disease_Homo sapiens_hsa050120.13857749
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12661131
132Alzheimers disease_Homo sapiens_hsa050100.11717331
133Glutamatergic synapse_Homo sapiens_hsa047240.11502242
134Thyroid hormone synthesis_Homo sapiens_hsa049180.11137469
135Type II diabetes mellitus_Homo sapiens_hsa049300.10137968
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.06549072
137Morphine addiction_Homo sapiens_hsa050320.05067840
138Protein digestion and absorption_Homo sapiens_hsa049740.04452146
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.03900611
140AMPK signaling pathway_Homo sapiens_hsa041520.03420052
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.02831787
142Taste transduction_Homo sapiens_hsa047420.01740846
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0119256
144Circadian entrainment_Homo sapiens_hsa04713-0.0105505
145Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0095887

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