WRAP53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.11071864
2DNA strand elongation (GO:0022616)4.91323300
3telomere maintenance via semi-conservative replication (GO:0032201)4.78347457
4DNA replication initiation (GO:0006270)4.61885650
5nucleobase biosynthetic process (GO:0046112)4.55327612
6DNA unwinding involved in DNA replication (GO:0006268)4.41844190
7purine nucleobase biosynthetic process (GO:0009113)4.39602130
8formation of translation preinitiation complex (GO:0001731)4.32256552
9DNA replication checkpoint (GO:0000076)4.25725457
10maturation of SSU-rRNA (GO:0030490)4.13622230
11telomere maintenance via recombination (GO:0000722)4.12238303
12proteasome assembly (GO:0043248)4.06292164
13DNA deamination (GO:0045006)3.99027740
14mitotic metaphase plate congression (GO:0007080)3.95115188
15mitotic recombination (GO:0006312)3.84651035
16ribosome biogenesis (GO:0042254)3.79509693
17DNA replication-dependent nucleosome organization (GO:0034723)3.76177854
18DNA replication-dependent nucleosome assembly (GO:0006335)3.76177854
19nucleotide-excision repair, DNA gap filling (GO:0006297)3.71998082
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.71931507
21telomere maintenance via telomere lengthening (GO:0010833)3.71898705
22ribosome assembly (GO:0042255)3.70691884
23establishment of integrated proviral latency (GO:0075713)3.66954375
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66765777
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.66529403
26ribosomal small subunit assembly (GO:0000028)3.64541865
27mitotic chromosome condensation (GO:0007076)3.61975367
28mitotic sister chromatid segregation (GO:0000070)3.60407455
29ribonucleoprotein complex biogenesis (GO:0022613)3.60342567
30protein localization to kinetochore (GO:0034501)3.57597218
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.57194962
32spliceosomal snRNP assembly (GO:0000387)3.56075032
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55547236
34regulation of mitochondrial translation (GO:0070129)3.55441457
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51090159
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50862521
37ribosomal small subunit biogenesis (GO:0042274)3.49167105
38pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.47616887
39folic acid-containing compound biosynthetic process (GO:0009396)3.45896487
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.44267116
41ribosomal large subunit biogenesis (GO:0042273)3.44162237
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41879851
43negative regulation of ligase activity (GO:0051352)3.41879851
44DNA ligation (GO:0006266)3.41150652
45transcription-coupled nucleotide-excision repair (GO:0006283)3.39117655
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38804326
47rRNA processing (GO:0006364)3.38388676
48metaphase plate congression (GO:0051310)3.37304563
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.36997043
50termination of RNA polymerase III transcription (GO:0006386)3.36997043
51viral transcription (GO:0019083)3.36061660
52protein localization to endoplasmic reticulum (GO:0070972)3.35940418
53rRNA modification (GO:0000154)3.34544571
54translational termination (GO:0006415)3.33980259
55UTP biosynthetic process (GO:0006228)3.32677801
56pseudouridine synthesis (GO:0001522)3.32023687
57viral life cycle (GO:0019058)3.31564821
58IMP biosynthetic process (GO:0006188)3.31438314
59cellular protein complex disassembly (GO:0043624)3.31139760
60CENP-A containing nucleosome assembly (GO:0034080)3.30725061
61DNA topological change (GO:0006265)3.30302913
62kinetochore assembly (GO:0051382)3.29073586
63chromatin remodeling at centromere (GO:0031055)3.28061784
64sister chromatid segregation (GO:0000819)3.26434175
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24824495
66translational initiation (GO:0006413)3.24814033
67rRNA metabolic process (GO:0016072)3.24378435
68mitotic nuclear envelope disassembly (GO:0007077)3.22704629
69cell cycle G1/S phase transition (GO:0044843)3.20762858
70G1/S transition of mitotic cell cycle (GO:0000082)3.20762858
71pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.20688735
72spliceosomal complex assembly (GO:0000245)3.17744824
73axonemal dynein complex assembly (GO:0070286)3.17540147
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16767094
75chaperone-mediated protein transport (GO:0072321)3.16461035
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16355556
77folic acid metabolic process (GO:0046655)3.16112757
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15339454
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15339454
80guanosine-containing compound biosynthetic process (GO:1901070)3.15336024
81GTP biosynthetic process (GO:0006183)3.14850752
82pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.14188674
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12501298
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12501298
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12501298
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12159926
87translational elongation (GO:0006414)3.12014618
88protein complex disassembly (GO:0043241)3.11448905
89signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10088288
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.10088288
91DNA strand renaturation (GO:0000733)3.09510716
92DNA replication-independent nucleosome organization (GO:0034724)3.09430350
93DNA replication-independent nucleosome assembly (GO:0006336)3.09430350
94mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08836908
95somatic hypermutation of immunoglobulin genes (GO:0016446)3.06805446
96somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06805446
97positive regulation of ligase activity (GO:0051351)3.04540343
98amino acid salvage (GO:0043102)3.03857248
99L-methionine salvage (GO:0071267)3.03857248
100L-methionine biosynthetic process (GO:0071265)3.03857248
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.03752631
102mitotic nuclear envelope reassembly (GO:0007084)3.02652251
103nuclear envelope reassembly (GO:0031468)3.02652251
104protein localization to chromosome, centromeric region (GO:0071459)3.02099967
105CTP biosynthetic process (GO:0006241)3.00517279
106CTP metabolic process (GO:0046036)3.00517279
107establishment of viral latency (GO:0019043)2.98860238
108regulation of cellular amino acid metabolic process (GO:0006521)2.98512181
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97917552
110IMP metabolic process (GO:0046040)2.96554104
111macromolecular complex disassembly (GO:0032984)2.95119299
112L-serine metabolic process (GO:0006563)2.94227035
113membrane disassembly (GO:0030397)2.93211843
114nuclear envelope disassembly (GO:0051081)2.93211843
115cullin deneddylation (GO:0010388)2.92251883
116SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92165283
117base-excision repair (GO:0006284)2.91967123
118negative regulation of RNA splicing (GO:0033119)2.89784047
119negative regulation of mRNA processing (GO:0050686)2.89772914
120UTP metabolic process (GO:0046051)2.89702257
121kinetochore organization (GO:0051383)2.89484936
122translation (GO:0006412)2.89114118
1237-methylguanosine mRNA capping (GO:0006370)2.88233751
124* telomere organization (GO:0032200)2.88065185
125telomere maintenance (GO:0000723)2.88065185
126negative regulation of chromosome segregation (GO:0051985)2.87996517
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87921695
128regulation of ubiquitin-protein transferase activity (GO:0051438)2.87861052
129cotranslational protein targeting to membrane (GO:0006613)2.87724641
130pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.87559913
131cellular component biogenesis (GO:0044085)2.87409626
132viral mRNA export from host cell nucleus (GO:0046784)2.86115698
133RNA splicing, via transesterification reactions (GO:0000375)2.85575535
134establishment of chromosome localization (GO:0051303)2.85248183
135protein targeting to ER (GO:0045047)2.85173036
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84867371
137ATP synthesis coupled proton transport (GO:0015986)2.84665401
138energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84665401
139base-excision repair, AP site formation (GO:0006285)2.84620438
140mRNA splicing, via spliceosome (GO:0000398)2.84411548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.32176921
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11917323
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76012836
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37919720
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.20132488
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17887629
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10979432
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.10585335
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.09666331
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04687681
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96032830
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.95294400
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94556992
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90335592
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86601580
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81530227
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70972910
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64313016
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63562382
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.56976528
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53933151
22XRN2_22483619_ChIP-Seq_HELA_Human2.36943434
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31572188
24VDR_23849224_ChIP-Seq_CD4+_Human2.26288102
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15140121
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13278390
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12938158
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11414956
29DCP1A_22483619_ChIP-Seq_HELA_Human2.06074169
30GABP_19822575_ChIP-Seq_HepG2_Human1.98205655
31FOXP3_21729870_ChIP-Seq_TREG_Human1.95899854
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95487016
33AR_21909140_ChIP-Seq_LNCAP_Human1.92862178
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88857830
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84235153
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80620043
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79715874
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78824220
39TTF2_22483619_ChIP-Seq_HELA_Human1.74517352
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.69886948
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69213732
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.62780662
43CIITA_25753668_ChIP-Seq_RAJI_Human1.62367326
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61376375
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58469980
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.56034701
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54710561
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53227136
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51478728
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49757252
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49543718
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48389917
53ELK1_19687146_ChIP-ChIP_HELA_Human1.48357319
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45628883
55KDM5A_27292631_Chip-Seq_BREAST_Human1.44775639
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36396511
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29415051
58MYC_22102868_ChIP-Seq_BL_Human1.28532554
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28316772
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26938286
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25755588
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25203458
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23854927
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20966724
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20427589
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17790887
67* FOXP1_21924763_ChIP-Seq_HESCs_Human1.15189104
68TFEB_21752829_ChIP-Seq_HELA_Human1.13913305
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.12935664
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12578112
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12501659
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12083295
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08803832
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08591418
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08048038
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06731424
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04126714
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03812772
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03181895
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02528232
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02455288
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01230046
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01107163
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98533287
85VDR_21846776_ChIP-Seq_THP-1_Human0.96387082
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96266485
87* TET1_21451524_ChIP-Seq_MESCs_Mouse0.96166859
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91213813
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90087171
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90087171
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90087171
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89037797
93* ELK1_22589737_ChIP-Seq_MCF10A_Human0.88937438
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.88658949
95OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88240333
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88151441
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.87683650
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87596117
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86861303
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.86735076
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86449799
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85366035
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85104985
104P68_20966046_ChIP-Seq_HELA_Human0.85045191
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84852814
106MYC_18940864_ChIP-ChIP_HL60_Human0.84559810
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84180590
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.81683486
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81633570
110ZNF263_19887448_ChIP-Seq_K562_Human0.81540816
111* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81047380
112IRF1_19129219_ChIP-ChIP_H3396_Human0.80134130
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.79891872
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79871352
115SPI1_23547873_ChIP-Seq_NB4_Human0.78779518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05984948
2MP0004957_abnormal_blastocyst_morpholog4.68486018
3MP0010094_abnormal_chromosome_stability4.64226995
4MP0003806_abnormal_nucleotide_metabolis4.62455299
5MP0003111_abnormal_nucleus_morphology4.49423446
6MP0008057_abnormal_DNA_replication4.30088120
7MP0003077_abnormal_cell_cycle4.03742511
8MP0008058_abnormal_DNA_repair3.43710362
9MP0008932_abnormal_embryonic_tissue2.88763752
10MP0001730_embryonic_growth_arrest2.68930651
11MP0008789_abnormal_olfactory_epithelium2.54361499
12MP0008007_abnormal_cellular_replicative2.41955303
13MP0005394_taste/olfaction_phenotype2.38497915
14MP0005499_abnormal_olfactory_system2.38497915
15MP0002396_abnormal_hematopoietic_system2.25035398
16MP0003123_paternal_imprinting2.23544791
17MP0000350_abnormal_cell_proliferation2.15400054
18MP0008877_abnormal_DNA_methylation1.98768790
19MP0003786_premature_aging1.95898013
20MP0009379_abnormal_foot_pigmentation1.90904391
21MP0003718_maternal_effect1.88691566
22MP0002653_abnormal_ependyma_morphology1.80770042
23MP0000049_abnormal_middle_ear1.70036423
24MP0001697_abnormal_embryo_size1.67879680
25MP0002080_prenatal_lethality1.63567737
26MP0001672_abnormal_embryogenesis/_devel1.63077247
27MP0005380_embryogenesis_phenotype1.63077247
28MP0000490_abnormal_crypts_of1.61913161
29MP0001529_abnormal_vocalization1.60796900
30MP0000313_abnormal_cell_death1.55685903
31MP0003950_abnormal_plasma_membrane1.54955608
32MP0002234_abnormal_pharynx_morphology1.50760008
33MP0002085_abnormal_embryonic_tissue1.49038465
34MP0003186_abnormal_redox_activity1.48796418
35MP0003984_embryonic_growth_retardation1.47035419
36MP0010030_abnormal_orbit_morphology1.45752743
37MP0008260_abnormal_autophagy1.45480492
38MP0009333_abnormal_splenocyte_physiolog1.44316498
39MP0002019_abnormal_tumor_incidence1.41394520
40MP0002088_abnormal_embryonic_growth/wei1.40537818
41MP0004133_heterotaxia1.36412900
42MP0004185_abnormal_adipocyte_glucose1.34510938
43MP0010307_abnormal_tumor_latency1.34484657
44MP0006036_abnormal_mitochondrial_physio1.33911537
45MP0002210_abnormal_sex_determination1.33048688
46MP0008995_early_reproductive_senescence1.30378916
47MP0001145_abnormal_male_reproductive1.25345710
48MP0003937_abnormal_limbs/digits/tail_de1.22865102
49MP0010352_gastrointestinal_tract_polyps1.22672156
50MP0001293_anophthalmia1.22575625
51MP0005083_abnormal_biliary_tract1.22460868
52MP0001727_abnormal_embryo_implantation1.22113277
53MP0002084_abnormal_developmental_patter1.20687034
54MP0004197_abnormal_fetal_growth/weight/1.17937252
55MP0004233_abnormal_muscle_weight1.17715940
56MP0000678_abnormal_parathyroid_gland1.13695333
57MP0001929_abnormal_gametogenesis1.12130901
58MP0003567_abnormal_fetal_cardiomyocyte1.11940175
59MP0002086_abnormal_extraembryonic_tissu1.11534917
60MP0004147_increased_porphyrin_level1.11014845
61MP0002132_abnormal_respiratory_system1.10907280
62MP0005075_abnormal_melanosome_morpholog1.09859646
63MP0003221_abnormal_cardiomyocyte_apopto1.09520216
64MP0003890_abnormal_embryonic-extraembry1.09431779
65MP0002697_abnormal_eye_size1.09120620
66MP0005623_abnormal_meninges_morphology1.08633008
67MP0006292_abnormal_olfactory_placode1.07288086
68MP0000689_abnormal_spleen_morphology1.05971666
69MP0003656_abnormal_erythrocyte_physiolo1.04977093
70MP0005451_abnormal_body_composition1.04662230
71MP0000703_abnormal_thymus_morphology1.04340544
72MP0000358_abnormal_cell_content/1.04307593
73MP0005266_abnormal_metabolism1.03225217
74MP0000653_abnormal_sex_gland1.02313823
75MP0003763_abnormal_thymus_physiology1.02139529
76MP0002722_abnormal_immune_system1.02007087
77MP0002249_abnormal_larynx_morphology0.97736436
78MP0003861_abnormal_nervous_system0.96731172
79MP0002398_abnormal_bone_marrow0.96390860
80MP0003136_yellow_coat_color0.95574952
81MP0009278_abnormal_bone_marrow0.95184205
82MP0002102_abnormal_ear_morphology0.95141439
83MP0001346_abnormal_lacrimal_gland0.94575511
84MP0001286_abnormal_eye_development0.94129127
85MP0002163_abnormal_gland_morphology0.93350436
86MP0009053_abnormal_anal_canal0.91296585
87MP0003119_abnormal_digestive_system0.90948339
88MP0006035_abnormal_mitochondrial_morpho0.90228027
89MP0001545_abnormal_hematopoietic_system0.89805655
90MP0005397_hematopoietic_system_phenotyp0.89805655
91MP0003315_abnormal_perineum_morphology0.85511843
92MP0002111_abnormal_tail_morphology0.85075641
93MP0002429_abnormal_blood_cell0.84512746
94MP0005384_cellular_phenotype0.83135238
95MP0005220_abnormal_exocrine_pancreas0.82316361
96MP0003942_abnormal_urinary_system0.79568050
97MP0004808_abnormal_hematopoietic_stem0.77856095
98MP0005501_abnormal_skin_physiology0.77524604
99MP0002233_abnormal_nose_morphology0.76456028
100MP0002160_abnormal_reproductive_system0.76296201
101MP0001915_intracranial_hemorrhage0.76270876
102MP0000537_abnormal_urethra_morphology0.76248588
103MP0005621_abnormal_cell_physiology0.74922998
104MP0009697_abnormal_copulation0.74030120
105MP0000920_abnormal_myelination0.73745749
106MP0003121_genomic_imprinting0.73666420
107MP0009672_abnormal_birth_weight0.72403243
108MP0004381_abnormal_hair_follicle0.72378150
109MP0006072_abnormal_retinal_apoptosis0.71533928
110MP0005391_vision/eye_phenotype0.68399374
111MP0005408_hypopigmentation0.68182553
112MP0006054_spinal_hemorrhage0.67778621
113MP0003938_abnormal_ear_development0.67653478
114MP0000716_abnormal_immune_system0.65989132
115MP0000465_gastrointestinal_hemorrhage0.65934980
116MP0009840_abnormal_foam_cell0.65503682
117MP0003755_abnormal_palate_morphology0.64989030
118MP0001485_abnormal_pinna_reflex0.64812044
119MP0003698_abnormal_male_reproductive0.64810492
120MP0000477_abnormal_intestine_morphology0.63111685
121MP0003385_abnormal_body_wall0.62144117
122MP0001764_abnormal_homeostasis0.58483164
123MP0001661_extended_life_span0.57730039
124MP0002161_abnormal_fertility/fecundity0.56374738
125MP0000372_irregular_coat_pigmentation0.54375143
126MP0002751_abnormal_autonomic_nervous0.52452748
127MP0002095_abnormal_skin_pigmentation0.52096984
128MP0005389_reproductive_system_phenotype0.51569233
129MP0002938_white_spotting0.50988264
130MP0002075_abnormal_coat/hair_pigmentati0.50929184
131MP0001119_abnormal_female_reproductive0.50604753
132MP0005023_abnormal_wound_healing0.49143852
133MP0002092_abnormal_eye_morphology0.48577396
134MP0001849_ear_inflammation0.48005014
135MP0002269_muscular_atrophy0.47827842

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)6.17109507
2Birth length less than 3rd percentile (HP:0003561)5.50234691
3Breast hypoplasia (HP:0003187)5.04341680
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.90499835
5Reticulocytopenia (HP:0001896)3.94105071
6Abnormality of cells of the erythroid lineage (HP:0012130)3.92384265
7Abnormal number of erythroid precursors (HP:0012131)3.80385617
8Oral leukoplakia (HP:0002745)3.77074020
9Acute necrotizing encephalopathy (HP:0006965)3.58441994
10Abnormal mitochondria in muscle tissue (HP:0008316)3.54584740
11Abnormal respiratory motile cilium physiology (HP:0012261)3.52160919
12CNS hypomyelination (HP:0003429)3.45700810
13Abnormal respiratory motile cilium morphology (HP:0005938)3.32123218
14Abnormal respiratory epithelium morphology (HP:0012253)3.32123218
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.30224753
16Carpal bone hypoplasia (HP:0001498)3.19419453
17Rhinitis (HP:0012384)3.13746370
18Abnormal ciliary motility (HP:0012262)3.13677577
19Microretrognathia (HP:0000308)3.11356712
20Acute encephalopathy (HP:0006846)3.09833469
21Patellar aplasia (HP:0006443)3.06529552
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.02679458
23Absent/shortened dynein arms (HP:0200106)3.02679458
24Selective tooth agenesis (HP:0001592)3.01767001
25Poikiloderma (HP:0001029)2.96104957
26Absent radius (HP:0003974)2.94692145
27* Rough bone trabeculation (HP:0100670)2.92091472
28Aplasia/Hypoplasia of the patella (HP:0006498)2.88499257
293-Methylglutaconic aciduria (HP:0003535)2.87426003
30Abnormality of glycolysis (HP:0004366)2.85069357
31Increased serum pyruvate (HP:0003542)2.85069357
32Macrocytic anemia (HP:0001972)2.80872009
33Ependymoma (HP:0002888)2.80126083
34Chronic bronchitis (HP:0004469)2.80015374
35Entropion (HP:0000621)2.80000057
36Degeneration of anterior horn cells (HP:0002398)2.79529933
37Abnormality of the anterior horn cell (HP:0006802)2.79529933
38Absent forearm bone (HP:0003953)2.78551723
39Aplasia involving forearm bones (HP:0009822)2.78551723
40Chromsome breakage (HP:0040012)2.77067361
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72824107
42Aplastic anemia (HP:0001915)2.69747940
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.69248094
44Duplicated collecting system (HP:0000081)2.68293151
45Medulloblastoma (HP:0002885)2.68007173
46Hepatic necrosis (HP:0002605)2.66731179
47Postnatal microcephaly (HP:0005484)2.62577983
48Increased hepatocellular lipid droplets (HP:0006565)2.58015838
49Abnormality of the labia minora (HP:0012880)2.55223603
50Abnormality of the ileum (HP:0001549)2.54607560
51* Premature graying of hair (HP:0002216)2.54421525
52Abnormality of chromosome stability (HP:0003220)2.52130384
53Facial cleft (HP:0002006)2.51161397
54Lipid accumulation in hepatocytes (HP:0006561)2.50493108
55Progressive macrocephaly (HP:0004481)2.49527814
56Meckel diverticulum (HP:0002245)2.48085605
57Cerebral edema (HP:0002181)2.45346365
58Secondary amenorrhea (HP:0000869)2.44396069
59Premature ovarian failure (HP:0008209)2.43537198
60Colon cancer (HP:0003003)2.41557702
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.41115725
62Abnormality of the preputium (HP:0100587)2.40704274
63Absent thumb (HP:0009777)2.37627668
64Abnormality of DNA repair (HP:0003254)2.37283853
65Trismus (HP:0000211)2.33470655
66Supernumerary spleens (HP:0009799)2.31977707
67Increased serum lactate (HP:0002151)2.29642012
68Exercise intolerance (HP:0003546)2.27752685
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.27700973
70Pancreatic fibrosis (HP:0100732)2.26886236
71Abnormal lung lobation (HP:0002101)2.26277611
72Nasal polyposis (HP:0100582)2.26038168
73Agnosia (HP:0010524)2.25738465
74Pallor (HP:0000980)2.25663189
75Preaxial hand polydactyly (HP:0001177)2.22911434
76Abnormal umbilical cord blood vessels (HP:0011403)2.21943077
77Single umbilical artery (HP:0001195)2.21943077
78Abnormality of the fetal cardiovascular system (HP:0010948)2.21943077
79* Bone marrow hypocellularity (HP:0005528)2.20828662
80Basal cell carcinoma (HP:0002671)2.19439540
81Sclerocornea (HP:0000647)2.16638381
82* Squamous cell carcinoma (HP:0002860)2.15528042
83Renal Fanconi syndrome (HP:0001994)2.15328146
84Horseshoe kidney (HP:0000085)2.15318770
85Small intestinal stenosis (HP:0012848)2.15253452
86Duodenal stenosis (HP:0100867)2.15253452
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.14896929
88Triphalangeal thumb (HP:0001199)2.14142679
89* Neoplasm of the pancreas (HP:0002894)2.14125239
90Abnormality of the umbilical cord (HP:0010881)2.13681514
91Ureteral duplication (HP:0000073)2.13663054
92Abnormal number of incisors (HP:0011064)2.13195061
93Hypoplastic pelvis (HP:0008839)2.12181797
94Rectal fistula (HP:0100590)2.11405814
95Rectovaginal fistula (HP:0000143)2.11405814
96Hepatocellular necrosis (HP:0001404)2.11094269
97Lactic acidosis (HP:0003128)2.10918054
98Optic nerve coloboma (HP:0000588)2.08936244
99Abnormality of midbrain morphology (HP:0002418)2.08932767
100Molar tooth sign on MRI (HP:0002419)2.08932767
101Microvesicular hepatic steatosis (HP:0001414)2.08299239
102Leukodystrophy (HP:0002415)2.08051114
103Broad distal phalanx of finger (HP:0009836)2.07396097
104Proximal placement of thumb (HP:0009623)2.05414075
105Sloping forehead (HP:0000340)2.05293090
106Hypoplasia of the pons (HP:0012110)2.04820292
107Progressive muscle weakness (HP:0003323)2.04107357
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03762439
109Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03762439
110Abnormal protein glycosylation (HP:0012346)2.03757167
111Abnormal glycosylation (HP:0012345)2.03757167
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03757167
113Abnormal protein N-linked glycosylation (HP:0012347)2.03757167
114Increased intramyocellular lipid droplets (HP:0012240)2.00027909
115Abnormality of the renal collecting system (HP:0004742)1.99723107
116* Pancytopenia (HP:0001876)1.99713917
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98977062
118Megaloblastic anemia (HP:0001889)1.98763039
119* Cellular immunodeficiency (HP:0005374)1.97329217
120Asplenia (HP:0001746)1.96428392
121IgM deficiency (HP:0002850)1.95686379
122Multiple enchondromatosis (HP:0005701)1.95215621
123Hypoplasia of the radius (HP:0002984)1.94608352
124* Abnormal trabecular bone morphology (HP:0100671)1.94489267
125Anencephaly (HP:0002323)1.92820651
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92387927
127Occipital encephalocele (HP:0002085)1.92277992
128Rhabdomyosarcoma (HP:0002859)1.91975157
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.91818643
130Neoplasm of the oral cavity (HP:0100649)1.91534355
131Type I transferrin isoform profile (HP:0003642)1.91523526
132Testicular atrophy (HP:0000029)1.91289570
133Atresia of the external auditory canal (HP:0000413)1.91161485
134Myelodysplasia (HP:0002863)1.91023061
135Duplication of thumb phalanx (HP:0009942)1.90079530
136CNS demyelination (HP:0007305)1.88691732
137Facial hemangioma (HP:0000329)1.88585282
138Increased CSF lactate (HP:0002490)1.86959646
139Impulsivity (HP:0100710)1.86326187
140Abnormality of reticulocytes (HP:0004312)1.86180617
141Median cleft lip (HP:0000161)1.85779183
142Emotional lability (HP:0000712)1.85633392
143Abnormality of the duodenum (HP:0002246)1.85346875
144Mitochondrial inheritance (HP:0001427)1.85009655
145Short thumb (HP:0009778)1.82315249
146Cleft eyelid (HP:0000625)1.82238581
147Panhypogammaglobulinemia (HP:0003139)1.82084705
148Pendular nystagmus (HP:0012043)1.81208946
149Cerebellar dysplasia (HP:0007033)1.80282204
150Bronchiectasis (HP:0002110)1.79394688
151Ectopic kidney (HP:0000086)1.77717451
152Abnormality of the pons (HP:0007361)1.76704114
153Holoprosencephaly (HP:0001360)1.76290977
154Increased muscle lipid content (HP:0009058)1.75453041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.17457101
2BUB15.00831528
3WEE14.46701364
4EIF2AK13.75814202
5PASK3.57535775
6CDC73.43124328
7TESK23.20930332
8SMG12.85717573
9STK162.68672775
10NEK22.29266616
11ZAK2.23652172
12NME22.20712576
13SRPK12.16744087
14TSSK62.03303626
15EIF2AK31.93947715
16BRSK21.93809176
17TTK1.90498016
18TAF11.88994181
19DYRK31.88139611
20VRK11.87910539
21PLK11.85624704
22CDK81.84844163
23TLK11.73000476
24PLK41.60742455
25MKNK11.57575080
26PBK1.53832085
27ACVR1B1.49999416
28NUAK11.47041476
29CDK71.45347003
30AURKB1.36282975
31NEK11.35560462
32CDK191.34601731
33BCKDK1.34336858
34ATR1.31565656
35BRSK11.31508935
36PAK41.31151926
37MAP3K81.31099389
38SCYL21.24411753
39LIMK11.23516460
40AURKA1.22107855
41CLK11.21502588
42MAP4K11.19894225
43CHEK21.12921453
44CHEK11.11606568
45PLK31.09607015
46MAP3K111.09031863
47STK41.07569206
48RPS6KA41.05763991
49CDK91.04023322
50KDR1.03949626
51STK101.03632937
52CDK41.01814901
53MAP3K100.93892352
54PAK10.93079030
55RPS6KB20.92068957
56IRAK30.89703642
57CCNB10.87741643
58NME10.83694362
59PIM20.83176489
60MKNK20.83027195
61BRAF0.81900575
62TRIM280.80018078
63TESK10.78343300
64CSNK1G30.77798958
65STK390.75286132
66DYRK20.73234709
67BRD40.71582822
68CDK20.70609306
69RPS6KA50.70381067
70GRK60.67503172
71PIM10.67246471
72CSNK2A20.66988901
73ARAF0.66792007
74DAPK10.66612285
75PNCK0.64489455
76CSNK2A10.64216112
77EPHA20.62156870
78CSNK1G20.60940452
79ATM0.59870999
80MAPK150.56990410
81OXSR10.54141403
82CDK10.53396419
83UHMK10.52374589
84MAP2K70.51510772
85CSNK1G10.48872971
86ABL20.48505825
87AKT20.46238639
88CDK11A0.45830426
89PRKCI0.44444543
90CSNK1A1L0.44042478
91CDK120.43221003
92BCR0.43187704
93EIF2AK20.43154624
94MST40.42681772
95PDK20.42489762
96CDK150.41036167
97CDK140.40087925
98MET0.39649839
99ALK0.38132623
100CDK180.38037715
101BTK0.37204331
102LRRK20.36240047
103MELK0.35947145
104FLT30.35314483
105EEF2K0.35077950
106TAOK20.34565368
107BLK0.34283903
108DAPK30.33847776
109TRIB30.33744996
110PDK30.32763752
111PDK40.32763752
112CSNK1E0.32111513
113NEK60.31546046
114MARK30.30854404
115PRKD30.26452806
116ILK0.24012775
117ICK0.23138294
118TGFBR10.22800867
119MAPKAPK50.22565960
120PRKDC0.21750337
121CAMK1D0.21749766
122PAK20.21716636
123CSNK1D0.21043187
124MAPK110.19728259
125MST1R0.18673102
126RPS6KA10.16742387
127ERBB40.16633550

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88614382
2Mismatch repair_Homo sapiens_hsa034304.18117451
3Proteasome_Homo sapiens_hsa030503.96858907
4RNA polymerase_Homo sapiens_hsa030203.59788616
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56218839
6Ribosome_Homo sapiens_hsa030103.33989002
7Spliceosome_Homo sapiens_hsa030403.21566924
8Homologous recombination_Homo sapiens_hsa034403.05510577
9Base excision repair_Homo sapiens_hsa034102.98611185
10RNA transport_Homo sapiens_hsa030132.79266955
11Nucleotide excision repair_Homo sapiens_hsa034202.75608842
12Pyrimidine metabolism_Homo sapiens_hsa002402.62005376
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40969904
14Cell cycle_Homo sapiens_hsa041102.32903052
15One carbon pool by folate_Homo sapiens_hsa006702.27260441
16Non-homologous end-joining_Homo sapiens_hsa034502.22207600
17Basal transcription factors_Homo sapiens_hsa030221.93230661
18Fanconi anemia pathway_Homo sapiens_hsa034601.89724029
19Vitamin B6 metabolism_Homo sapiens_hsa007501.67790440
20Folate biosynthesis_Homo sapiens_hsa007901.63608098
21RNA degradation_Homo sapiens_hsa030181.50468681
22Purine metabolism_Homo sapiens_hsa002301.47509353
23Protein export_Homo sapiens_hsa030601.45149301
24mRNA surveillance pathway_Homo sapiens_hsa030151.43220943
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37141812
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28486931
27Pentose phosphate pathway_Homo sapiens_hsa000301.27174900
28p53 signaling pathway_Homo sapiens_hsa041151.18587641
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.16857986
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15776609
31Biosynthesis of amino acids_Homo sapiens_hsa012301.13051438
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12859054
33Epstein-Barr virus infection_Homo sapiens_hsa051691.07660615
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.00785408
35Parkinsons disease_Homo sapiens_hsa050120.97818164
36Glutathione metabolism_Homo sapiens_hsa004800.97413948
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.93150055
38Systemic lupus erythematosus_Homo sapiens_hsa053220.91977983
39Huntingtons disease_Homo sapiens_hsa050160.86366371
40Sulfur relay system_Homo sapiens_hsa041220.85217533
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81650741
42Oxidative phosphorylation_Homo sapiens_hsa001900.81102541
43Fatty acid elongation_Homo sapiens_hsa000620.79065850
44Selenocompound metabolism_Homo sapiens_hsa004500.75573486
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74817158
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74446193
47Carbon metabolism_Homo sapiens_hsa012000.72482916
48Arginine and proline metabolism_Homo sapiens_hsa003300.72003837
49Viral carcinogenesis_Homo sapiens_hsa052030.70931327
50Oocyte meiosis_Homo sapiens_hsa041140.70697230
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68580498
52Primary immunodeficiency_Homo sapiens_hsa053400.63509001
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58216985
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55107818
55Herpes simplex infection_Homo sapiens_hsa051680.54055311
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53445339
57Galactose metabolism_Homo sapiens_hsa000520.52521275
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52456610
59Regulation of autophagy_Homo sapiens_hsa041400.49326785
60Metabolic pathways_Homo sapiens_hsa011000.49315268
61Fructose and mannose metabolism_Homo sapiens_hsa000510.47330052
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46938265
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46640249
64Linoleic acid metabolism_Homo sapiens_hsa005910.45303621
65Antigen processing and presentation_Homo sapiens_hsa046120.44670827
66Cardiac muscle contraction_Homo sapiens_hsa042600.44111410
67Steroid biosynthesis_Homo sapiens_hsa001000.43839525
68HTLV-I infection_Homo sapiens_hsa051660.39362669
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38334482
70Bladder cancer_Homo sapiens_hsa052190.35783224
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34195965
72Pyruvate metabolism_Homo sapiens_hsa006200.30101856
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29889095
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29174768
75Alzheimers disease_Homo sapiens_hsa050100.29066076
76Arachidonic acid metabolism_Homo sapiens_hsa005900.28413900
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28162641
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.27288924
79Ether lipid metabolism_Homo sapiens_hsa005650.26630217
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25339701
81Alcoholism_Homo sapiens_hsa050340.24205479
82Thyroid cancer_Homo sapiens_hsa052160.24035742
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23322176
84Legionellosis_Homo sapiens_hsa051340.22362737
85Shigellosis_Homo sapiens_hsa051310.21659379
86Wnt signaling pathway_Homo sapiens_hsa043100.20999380
87Lysine degradation_Homo sapiens_hsa003100.20699675
88Vitamin digestion and absorption_Homo sapiens_hsa049770.20180123
89Phenylalanine metabolism_Homo sapiens_hsa003600.20082262
90Tyrosine metabolism_Homo sapiens_hsa003500.19500784
91Notch signaling pathway_Homo sapiens_hsa043300.18863248
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18649664
93Small cell lung cancer_Homo sapiens_hsa052220.17141944
94Apoptosis_Homo sapiens_hsa042100.16367127
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.14349902
96Propanoate metabolism_Homo sapiens_hsa006400.13783447
97N-Glycan biosynthesis_Homo sapiens_hsa005100.12681252
98MicroRNAs in cancer_Homo sapiens_hsa052060.12646217
99Vibrio cholerae infection_Homo sapiens_hsa051100.11733244
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11732363
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11116280
102Basal cell carcinoma_Homo sapiens_hsa052170.11053304
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10387136
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.09440109
105Hippo signaling pathway_Homo sapiens_hsa043900.08925296
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07737843
107Sulfur metabolism_Homo sapiens_hsa009200.06460307
108Arginine biosynthesis_Homo sapiens_hsa002200.06061285
109Colorectal cancer_Homo sapiens_hsa052100.05369951
110Renin-angiotensin system_Homo sapiens_hsa046140.05280667
111Hematopoietic cell lineage_Homo sapiens_hsa046400.02662454
112Hedgehog signaling pathway_Homo sapiens_hsa043400.01552829
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.01359252
114Histidine metabolism_Homo sapiens_hsa003400.00414075
115Pathways in cancer_Homo sapiens_hsa052000.00219070
116Peroxisome_Homo sapiens_hsa04146-0.0143447
117Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0137773
118SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0100312
119Measles_Homo sapiens_hsa05162-0.0083004
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0015792

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