WRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.01024129
2presynaptic membrane assembly (GO:0097105)4.84851886
3pyrimidine nucleobase catabolic process (GO:0006208)4.71260767
4presynaptic membrane organization (GO:0097090)4.61649539
5protein deneddylation (GO:0000338)4.55128409
6negative regulation of dendrite morphogenesis (GO:0050774)4.35659446
7neuron cell-cell adhesion (GO:0007158)4.30401122
8sequestering of actin monomers (GO:0042989)4.01176322
9chaperone-mediated protein transport (GO:0072321)3.99908893
10epithelial cilium movement (GO:0003351)3.89248868
11postsynaptic membrane organization (GO:0001941)3.84375132
12nucleobase catabolic process (GO:0046113)3.79624504
13negative regulation of synaptic transmission, GABAergic (GO:0032229)3.75318105
14vocalization behavior (GO:0071625)3.71576116
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69354338
16neurotransmitter-gated ion channel clustering (GO:0072578)3.64949475
17cilium movement (GO:0003341)3.61637282
18protein neddylation (GO:0045116)3.57345821
19negative regulation of dendrite development (GO:2000171)3.56578686
20positive regulation of mitochondrial fission (GO:0090141)3.50925498
21regulation of cilium movement (GO:0003352)3.50709633
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44610388
23synaptic vesicle exocytosis (GO:0016079)3.38148607
24protein complex biogenesis (GO:0070271)3.37346287
25axonemal dynein complex assembly (GO:0070286)3.34714715
26protein localization to cilium (GO:0061512)3.26793041
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23602542
28serotonin receptor signaling pathway (GO:0007210)3.23151190
29startle response (GO:0001964)3.21870684
30protein localization to synapse (GO:0035418)3.21606110
31neuron-neuron synaptic transmission (GO:0007270)3.21174096
32nonmotile primary cilium assembly (GO:0035058)3.19119574
33regulation of glutamate receptor signaling pathway (GO:1900449)3.16759009
34protein-cofactor linkage (GO:0018065)3.16063620
35platelet dense granule organization (GO:0060155)3.14258506
36positive regulation of synapse assembly (GO:0051965)3.14162289
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12278236
38transferrin transport (GO:0033572)3.10740489
39positive regulation of amino acid transport (GO:0051957)3.10042473
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05000863
41dopamine transport (GO:0015872)3.03342256
42synaptic transmission, glutamatergic (GO:0035249)3.01938315
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01578060
44axoneme assembly (GO:0035082)3.00929739
45mitochondrial respiratory chain complex assembly (GO:0033108)3.00239695
46striatum development (GO:0021756)2.99633296
47NADH dehydrogenase complex assembly (GO:0010257)2.97701645
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97701645
49mitochondrial respiratory chain complex I assembly (GO:0032981)2.97701645
50ATP hydrolysis coupled proton transport (GO:0015991)2.96913138
51energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.96913138
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96239096
53regulation of synaptic vesicle exocytosis (GO:2000300)2.94642708
54cilium organization (GO:0044782)2.94201233
55cilium assembly (GO:0042384)2.93670928
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90634179
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87626643
58behavioral response to nicotine (GO:0035095)2.86943237
59viral protein processing (GO:0019082)2.86811789
60gamma-aminobutyric acid transport (GO:0015812)2.86237432
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86138655
62synaptic vesicle maturation (GO:0016188)2.86092517
63ferric iron transport (GO:0015682)2.86016444
64trivalent inorganic cation transport (GO:0072512)2.86016444
65dendrite development (GO:0016358)2.84697857
66cilium morphogenesis (GO:0060271)2.84396555
67inositol phosphate catabolic process (GO:0071545)2.83873881
68protein polyglutamylation (GO:0018095)2.83671791
69regulation of synaptic transmission, GABAergic (GO:0032228)2.79571930
70neuronal action potential propagation (GO:0019227)2.79440783
71energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78924591
72ATP synthesis coupled proton transport (GO:0015986)2.78924591
73negative regulation of heart rate (GO:0010459)2.78152249
74neurofilament cytoskeleton organization (GO:0060052)2.76005506
75regulation of respiratory system process (GO:0044065)2.74942462
76cytochrome complex assembly (GO:0017004)2.74688456
77axonal fasciculation (GO:0007413)2.72606768
78regulation of glutamate secretion (GO:0014048)2.71405051
79retinal ganglion cell axon guidance (GO:0031290)2.70653433
80positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70011920
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.69153375
82opioid receptor signaling pathway (GO:0038003)2.68769753
83regulation of synaptic vesicle transport (GO:1902803)2.67156905
84glycosphingolipid biosynthetic process (GO:0006688)2.66792467
85auditory behavior (GO:0031223)2.66474737
86cilium or flagellum-dependent cell motility (GO:0001539)2.66430802
87transmission of nerve impulse (GO:0019226)2.65090920
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65083284
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65083284
90microtubule depolymerization (GO:0007019)2.65033809
91synaptic vesicle docking involved in exocytosis (GO:0016081)2.64008058
92proteasome assembly (GO:0043248)2.62535610
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.62152364
94intraciliary transport (GO:0042073)2.61584300
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60865056
96neurotransmitter uptake (GO:0001504)2.59745435
97establishment of melanosome localization (GO:0032401)2.58854695
98glutamate receptor signaling pathway (GO:0007215)2.57891260
99anterograde axon cargo transport (GO:0008089)2.57378277
100response to cocaine (GO:0042220)2.57104646
101respiratory chain complex IV assembly (GO:0008535)2.56838919
102neuron recognition (GO:0008038)2.56004844
103DNA double-strand break processing (GO:0000729)2.55831057
104melanosome transport (GO:0032402)2.52857129
105neurotransmitter secretion (GO:0007269)2.52728115
106regulation of synapse assembly (GO:0051963)2.52465236
107regulation of microtubule-based movement (GO:0060632)2.51943361
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.51659227
109anterograde synaptic vesicle transport (GO:0048490)2.51406967
110glutamate secretion (GO:0014047)2.50267593
111regulation of mitochondrial fission (GO:0090140)2.49484602
112organelle disassembly (GO:1903008)2.48122825
113negative regulation of response to food (GO:0032096)2.47370225
114negative regulation of appetite (GO:0032099)2.47370225
115regulation of synapse structural plasticity (GO:0051823)2.47267874
116long-term synaptic potentiation (GO:0060291)2.46181084
117synaptic vesicle endocytosis (GO:0048488)2.46126577
118establishment of mitochondrion localization (GO:0051654)2.45561131
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44779548
120cytoskeleton-dependent intracellular transport (GO:0030705)2.44681784
121electron transport chain (GO:0022900)2.44427734
122hippocampus development (GO:0021766)2.42808035
123negative regulation of neurotransmitter transport (GO:0051589)2.41915469
124positive regulation of protein homodimerization activity (GO:0090073)2.41794814
125establishment of pigment granule localization (GO:0051905)2.41552234
126mannosylation (GO:0097502)2.41030343
127histone H2A acetylation (GO:0043968)2.40034543
128regulation of respiratory gaseous exchange (GO:0043576)2.39464625
129ribonucleoprotein complex disassembly (GO:0032988)2.39193124
130synapse assembly (GO:0007416)2.38812275
131cholesterol biosynthetic process (GO:0006695)2.38774715
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.38452855
133microtubule-based transport (GO:0010970)2.38175858
1342-deoxyribonucleotide biosynthetic process (GO:0009265)2.38007900
135deoxyribose phosphate biosynthetic process (GO:0046385)2.38007900
136neuromuscular synaptic transmission (GO:0007274)2.36975513
137sympathetic nervous system development (GO:0048485)2.36763921
138respiratory electron transport chain (GO:0022904)2.36246293
139female mating behavior (GO:0060180)2.36072817
140regulation of synaptic transmission, glutamatergic (GO:0051966)2.36050693
1417-methylguanosine mRNA capping (GO:0006370)2.36001050
142neuron fate determination (GO:0048664)2.35207213
143pigment granule transport (GO:0051904)2.35040810
144regulation of protein kinase A signaling (GO:0010738)2.34384761
1457-methylguanosine RNA capping (GO:0009452)2.34233836
146RNA capping (GO:0036260)2.34233836
147microtubule polymerization or depolymerization (GO:0031109)2.34099186
148regulation of feeding behavior (GO:0060259)2.33497073
149protein localization to microtubule (GO:0035372)2.33329369
150mechanosensory behavior (GO:0007638)2.32856983
151sterol biosynthetic process (GO:0016126)2.32222774
152cellular component assembly involved in morphogenesis (GO:0010927)2.30641087
153positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.28565276
154limb bud formation (GO:0060174)2.28188693
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.28050937
156positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.26346206
157fatty acid elongation (GO:0030497)2.25075003
158retinal cone cell development (GO:0046549)2.24889200
159melanosome localization (GO:0032400)2.24887011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.24354935
2GBX2_23144817_ChIP-Seq_PC3_Human4.14024054
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01149589
4ZNF274_21170338_ChIP-Seq_K562_Hela2.66327352
5TAF15_26573619_Chip-Seq_HEK293_Human2.63973567
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47749916
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47653751
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40697273
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36661882
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28502948
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24182383
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09586228
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06869298
14FUS_26573619_Chip-Seq_HEK293_Human2.04014198
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03960864
16P300_19829295_ChIP-Seq_ESCs_Human1.93473655
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91292651
18RNF2_27304074_Chip-Seq_NSC_Mouse1.90004008
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.87197821
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86896833
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83890062
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82477076
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81273107
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.80874774
25IGF1R_20145208_ChIP-Seq_DFB_Human1.79803432
26REST_21632747_ChIP-Seq_MESCs_Mouse1.75860459
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72893472
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.71083248
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68536376
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64311587
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63202045
32VDR_22108803_ChIP-Seq_LS180_Human1.61633261
33SMAD4_21799915_ChIP-Seq_A2780_Human1.59782043
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59628932
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58719513
36EWS_26573619_Chip-Seq_HEK293_Human1.58576845
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57986536
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54606630
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53623650
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52934068
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.52321761
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51788587
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50600768
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49023048
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45754159
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45754159
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45632756
48* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44749160
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44533514
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43842513
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43188976
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.42761255
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41631478
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.41463352
55ER_23166858_ChIP-Seq_MCF-7_Human1.39297482
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38542856
57JUN_21703547_ChIP-Seq_K562_Human1.37896666
58ELK1_19687146_ChIP-ChIP_HELA_Human1.37556588
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37352154
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34695959
61* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30240987
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.26571725
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25524483
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.25419271
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25160454
66CBP_20019798_ChIP-Seq_JUKART_Human1.25160454
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24854076
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.24482483
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.23827406
70* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22972725
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22758762
72SOX9_26525672_Chip-Seq_HEART_Mouse1.21953491
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.19862505
74TP53_22573176_ChIP-Seq_HFKS_Human1.19580841
75* MYC_18940864_ChIP-ChIP_HL60_Human1.19476860
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.18846224
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.16792232
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16638807
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15946329
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15923719
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.15228865
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13872224
83P53_22387025_ChIP-Seq_ESCs_Mouse1.12865896
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12680302
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12188003
86* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10200869
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09531636
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09446479
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08610982
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08607778
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08332651
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07784487
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.07782448
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07389612
95BCAT_22108803_ChIP-Seq_LS180_Human1.07287839
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.07059386
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.07048890
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06934217
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06916524
100* IRF1_19129219_ChIP-ChIP_H3396_Human1.06330504
101SOX2_19829295_ChIP-Seq_ESCs_Human1.06328381
102NANOG_19829295_ChIP-Seq_ESCs_Human1.06328381
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06102808
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06102808
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05895860
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05678254
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05042271
108AR_25329375_ChIP-Seq_VCAP_Human1.04400720
109* HTT_18923047_ChIP-ChIP_STHdh_Human1.04317754
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04311207
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.03669439
112RUNX2_22187159_ChIP-Seq_PCA_Human1.03204293
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.02659585
114STAT3_23295773_ChIP-Seq_U87_Human1.02409288
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.02243117
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02054076
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01313877
118TCF4_22108803_ChIP-Seq_LS180_Human1.00466441
119SMAD_19615063_ChIP-ChIP_OVARY_Human1.00059880
120P300_18555785_Chip-Seq_ESCs_Mouse0.99403660
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99372917
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99190316
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99168915
124TCF4_23295773_ChIP-Seq_U87_Human0.98450342
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97187421
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.96979640
127VDR_23849224_ChIP-Seq_CD4+_Human0.96330663
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96201171
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96061276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.95613771
2MP0001188_hyperpigmentation2.87151212
3MP0001529_abnormal_vocalization2.70906819
4MP0002735_abnormal_chemical_nociception2.64000649
5MP0001968_abnormal_touch/_nociception2.63198701
6MP0004859_abnormal_synaptic_plasticity2.61313826
7MP0006276_abnormal_autonomic_nervous2.58679568
8MP0003635_abnormal_synaptic_transmissio2.49137857
9MP0009046_muscle_twitch2.46796063
10MP0009745_abnormal_behavioral_response2.46454314
11MP0002736_abnormal_nociception_after2.40202027
12MP0003122_maternal_imprinting2.28266012
13MP0004270_analgesia2.25767234
14MP0002734_abnormal_mechanical_nocicepti2.24357403
15MP0002822_catalepsy2.21437089
16MP0002063_abnormal_learning/memory/cond2.21374136
17MP0002064_seizures2.18957763
18MP0002572_abnormal_emotion/affect_behav2.17179031
19MP0003787_abnormal_imprinting2.15041875
20MP0002272_abnormal_nervous_system2.10420974
21MP0005423_abnormal_somatic_nervous2.03098941
22MP0001986_abnormal_taste_sensitivity2.01657547
23MP0005646_abnormal_pituitary_gland2.00645137
24MP0006292_abnormal_olfactory_placode2.00547863
25MP0001984_abnormal_olfaction1.98919389
26MP0000778_abnormal_nervous_system1.95872636
27MP0008877_abnormal_DNA_methylation1.84091278
28MP0001486_abnormal_startle_reflex1.80993084
29MP0001905_abnormal_dopamine_level1.80370869
30MP0005171_absent_coat_pigmentation1.77893577
31MP0002067_abnormal_sensory_capabilities1.73619755
32MP0002653_abnormal_ependyma_morphology1.73510184
33MP0004142_abnormal_muscle_tone1.72487790
34MP0002184_abnormal_innervation1.71144825
35MP0003121_genomic_imprinting1.70705636
36MP0005394_taste/olfaction_phenotype1.66244358
37MP0005499_abnormal_olfactory_system1.66244358
38MP0004133_heterotaxia1.65285248
39MP0005645_abnormal_hypothalamus_physiol1.65092996
40MP0002751_abnormal_autonomic_nervous1.63085167
41MP0002876_abnormal_thyroid_physiology1.55495821
42MP0008789_abnormal_olfactory_epithelium1.54837556
43MP0009697_abnormal_copulation1.54154550
44MP0005386_behavior/neurological_phenoty1.51156287
45MP0004924_abnormal_behavior1.51156287
46MP0005084_abnormal_gallbladder_morpholo1.50714707
47MP0000566_synostosis1.49968596
48MP0001970_abnormal_pain_threshold1.48387194
49MP0002557_abnormal_social/conspecific_i1.47530277
50MP0005409_darkened_coat_color1.47202834
51MP0003011_delayed_dark_adaptation1.46394193
52MP0002733_abnormal_thermal_nociception1.45273545
53MP0005187_abnormal_penis_morphology1.42071572
54MP0001440_abnormal_grooming_behavior1.41945734
55MP0001501_abnormal_sleep_pattern1.37994742
56MP0010386_abnormal_urinary_bladder1.37864420
57MP0003123_paternal_imprinting1.34936067
58MP0000015_abnormal_ear_pigmentation1.34595588
59MP0002938_white_spotting1.28483473
60MP0000569_abnormal_digit_pigmentation1.24495880
61MP0000372_irregular_coat_pigmentation1.22884394
62MP0000631_abnormal_neuroendocrine_gland1.21044141
63MP0003136_yellow_coat_color1.19559259
64MP0002882_abnormal_neuron_morphology1.19272971
65MP0002638_abnormal_pupillary_reflex1.18725886
66MP0001485_abnormal_pinna_reflex1.17211027
67MP0004811_abnormal_neuron_physiology1.16896481
68MP0003315_abnormal_perineum_morphology1.14046459
69MP0002234_abnormal_pharynx_morphology1.09782705
70MP0000955_abnormal_spinal_cord1.09230009
71MP0001963_abnormal_hearing_physiology1.09110727
72MP0008569_lethality_at_weaning1.08357378
73MP0001177_atelectasis1.06520254
74MP0003879_abnormal_hair_cell1.04744126
75MP0002160_abnormal_reproductive_system1.04271793
76MP0004885_abnormal_endolymph1.03081477
77MP0002233_abnormal_nose_morphology1.01690740
78MP0008058_abnormal_DNA_repair1.00642673
79MP0002066_abnormal_motor_capabilities/c1.00634140
80MP0003718_maternal_effect1.00196931
81MP0000026_abnormal_inner_ear0.98989178
82MP0002090_abnormal_vision0.98987483
83MP0002752_abnormal_somatic_nervous0.97791255
84MP0004215_abnormal_myocardial_fiber0.96814815
85MP0005551_abnormal_eye_electrophysiolog0.95261853
86MP0005248_abnormal_Harderian_gland0.94726793
87MP0002152_abnormal_brain_morphology0.93148307
88MP0004147_increased_porphyrin_level0.93052553
89MP0002909_abnormal_adrenal_gland0.92316351
90MP0003786_premature_aging0.92074644
91MP0008872_abnormal_physiological_respon0.91744518
92MP0001293_anophthalmia0.91041381
93MP0000049_abnormal_middle_ear0.91039642
94MP0000516_abnormal_urinary_system0.87370862
95MP0005367_renal/urinary_system_phenotyp0.87370862
96MP0004742_abnormal_vestibular_system0.86566815
97MP0003119_abnormal_digestive_system0.85163665
98MP0008875_abnormal_xenobiotic_pharmacok0.84283104
99MP0000647_abnormal_sebaceous_gland0.83686457
100MP0001299_abnormal_eye_distance/0.83412187
101MP0003698_abnormal_male_reproductive0.81849605
102MP0003937_abnormal_limbs/digits/tail_de0.81424857
103MP0002069_abnormal_eating/drinking_beha0.80932006
104MP0005195_abnormal_posterior_eye0.80247028
105MP0002282_abnormal_trachea_morphology0.78350124
106MP0009379_abnormal_foot_pigmentation0.77443718
107MP0005410_abnormal_fertilization0.75870417
108MP0004858_abnormal_nervous_system0.75429224
109MP0006036_abnormal_mitochondrial_physio0.74710188
110MP0008007_abnormal_cellular_replicative0.74310502
111MP0002102_abnormal_ear_morphology0.72384772
112MP0004085_abnormal_heartbeat0.71210567
113MP0002229_neurodegeneration0.70439666
114MP0006035_abnormal_mitochondrial_morpho0.70388032
115MP0000681_abnormal_thyroid_gland0.69760100
116MP0006072_abnormal_retinal_apoptosis0.68788605
117MP0003385_abnormal_body_wall0.67997528
118MP0003861_abnormal_nervous_system0.67896546
119MP0009250_abnormal_appendicular_skeleto0.67863601
120MP0002837_dystrophic_cardiac_calcinosis0.67734986
121MP0004145_abnormal_muscle_electrophysio0.65391071
122MP0005253_abnormal_eye_physiology0.65346743
123MP0004134_abnormal_chest_morphology0.64362471
124MP0008260_abnormal_autophagy0.62795247
125MP0005389_reproductive_system_phenotype0.62304394
126MP0003938_abnormal_ear_development0.61808215
127MP0003890_abnormal_embryonic-extraembry0.61546231
128MP0001943_abnormal_respiration0.60853822
129MP0001502_abnormal_circadian_rhythm0.60613729

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.79333080
2Focal motor seizures (HP:0011153)4.78146139
3Acute necrotizing encephalopathy (HP:0006965)4.08033694
4Febrile seizures (HP:0002373)4.00848143
5Abnormal mitochondria in muscle tissue (HP:0008316)3.72337098
6Hypothermia (HP:0002045)3.69866913
7Atonic seizures (HP:0010819)3.59856410
8Progressive macrocephaly (HP:0004481)3.57607066
9Gait imbalance (HP:0002141)3.51937903
10Medial flaring of the eyebrow (HP:0010747)3.43875085
11Epileptic encephalopathy (HP:0200134)3.38107001
12Abnormal respiratory motile cilium morphology (HP:0005938)3.32366435
13Abnormal respiratory epithelium morphology (HP:0012253)3.32366435
14Congenital primary aphakia (HP:0007707)3.32089552
15Abnormal ciliary motility (HP:0012262)3.27725177
16Mitochondrial inheritance (HP:0001427)3.25142968
17Nephrogenic diabetes insipidus (HP:0009806)3.24782157
18Hyperventilation (HP:0002883)3.18936789
19Abnormality of the labia minora (HP:0012880)3.13377184
20Abnormal respiratory motile cilium physiology (HP:0012261)3.11315819
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.05323177
22Pheochromocytoma (HP:0002666)3.01294745
23Acute encephalopathy (HP:0006846)2.97305012
24Increased CSF lactate (HP:0002490)2.93302799
25Neuroendocrine neoplasm (HP:0100634)2.83445031
26Rhinitis (HP:0012384)2.80858440
27Hepatocellular necrosis (HP:0001404)2.74188267
28Retinal dysplasia (HP:0007973)2.73739263
29Increased serum pyruvate (HP:0003542)2.72110131
30Abnormality of glycolysis (HP:0004366)2.72110131
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.69489099
32Absent/shortened dynein arms (HP:0200106)2.69489099
33Poor coordination (HP:0002370)2.65972080
34Genital tract atresia (HP:0001827)2.62749549
35Myokymia (HP:0002411)2.61831094
36Vaginal atresia (HP:0000148)2.59521272
37Limb dystonia (HP:0002451)2.54737626
38Occipital encephalocele (HP:0002085)2.50266843
39Poor suck (HP:0002033)2.50213978
40Birth length less than 3rd percentile (HP:0003561)2.48222117
41Focal seizures (HP:0007359)2.44865293
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.39497306
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39497306
44Progressive cerebellar ataxia (HP:0002073)2.37664054
45Optic disc pallor (HP:0000543)2.37498245
46Abnormality of the corticospinal tract (HP:0002492)2.29750802
47True hermaphroditism (HP:0010459)2.28328218
48Pancreatic fibrosis (HP:0100732)2.23014401
49Cortical dysplasia (HP:0002539)2.22791548
50Failure to thrive in infancy (HP:0001531)2.21134278
51Hemiparesis (HP:0001269)2.20306708
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.19200851
53Methylmalonic acidemia (HP:0002912)2.17207256
54Broad-based gait (HP:0002136)2.15803693
55Drooling (HP:0002307)2.15399828
56Abnormality of the renal medulla (HP:0100957)2.15200441
57Hypsarrhythmia (HP:0002521)2.15170691
58Specific learning disability (HP:0001328)2.13712084
59Absence seizures (HP:0002121)2.12576132
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.10912984
61Atrophy/Degeneration involving motor neurons (HP:0007373)2.10615004
62EEG with generalized epileptiform discharges (HP:0011198)2.09289352
63Renal Fanconi syndrome (HP:0001994)2.08310952
64Type II lissencephaly (HP:0007260)2.05338144
65Sclerocornea (HP:0000647)2.05308335
66Short tibia (HP:0005736)2.02153077
67Polyphagia (HP:0002591)2.01032379
68Aplasia/Hypoplasia of the lens (HP:0008063)2.00227159
69Anencephaly (HP:0002323)1.98557602
70Lipid accumulation in hepatocytes (HP:0006561)1.98182375
71Amyotrophic lateral sclerosis (HP:0007354)1.97632767
72Tubulointerstitial nephritis (HP:0001970)1.97387430
73Cystic liver disease (HP:0006706)1.97109701
74Dialeptic seizures (HP:0011146)1.96714869
75Fetal akinesia sequence (HP:0001989)1.94919924
76Chronic hepatic failure (HP:0100626)1.94908435
77Leukodystrophy (HP:0002415)1.94059749
78Increased serum lactate (HP:0002151)1.93832715
79Pachygyria (HP:0001302)1.93170663
80Generalized tonic-clonic seizures (HP:0002069)1.92919012
81Progressive inability to walk (HP:0002505)1.92631474
82Sleep apnea (HP:0010535)1.92541943
83Decreased testicular size (HP:0008734)1.92487190
84Male pseudohermaphroditism (HP:0000037)1.92099340
85Exercise intolerance (HP:0003546)1.91647722
86Degeneration of anterior horn cells (HP:0002398)1.90981559
87Abnormality of the anterior horn cell (HP:0006802)1.90981559
88Morphological abnormality of the pyramidal tract (HP:0002062)1.90786681
89Gaze-evoked nystagmus (HP:0000640)1.90778363
90Spastic tetraplegia (HP:0002510)1.88307465
91Hyperglycinemia (HP:0002154)1.87117525
92Excessive salivation (HP:0003781)1.87076221
93Abnormality of midbrain morphology (HP:0002418)1.86850406
94Molar tooth sign on MRI (HP:0002419)1.86850406
95Optic nerve hypoplasia (HP:0000609)1.85490427
96Hepatic necrosis (HP:0002605)1.85350946
97Preaxial hand polydactyly (HP:0001177)1.85203083
98Cerebral edema (HP:0002181)1.82989031
99Inability to walk (HP:0002540)1.82312339
100Esotropia (HP:0000565)1.81952711
101Impaired vibration sensation in the lower limbs (HP:0002166)1.81564325
102Postaxial hand polydactyly (HP:0001162)1.80321532
1033-Methylglutaconic aciduria (HP:0003535)1.79948450
104Respiratory failure (HP:0002878)1.79455869
105Unsteady gait (HP:0002317)1.79447679
106Lactic acidosis (HP:0003128)1.79322822
107Urinary urgency (HP:0000012)1.77516420
108Aganglionic megacolon (HP:0002251)1.77488705
109Broad foot (HP:0001769)1.76509654
110Renal cortical cysts (HP:0000803)1.75759720
111Muscular hypotonia of the trunk (HP:0008936)1.73917200
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73690539
113Protruding tongue (HP:0010808)1.72880112
114Narrow forehead (HP:0000341)1.72224818
115Bifid tongue (HP:0010297)1.72077764
116Hypoplastic left heart (HP:0004383)1.71236665
117Pancreatic cysts (HP:0001737)1.70762882
118Neoplasm of the peripheral nervous system (HP:0100007)1.69709834
119Narrow nasal bridge (HP:0000446)1.69682856
120Abnormal eating behavior (HP:0100738)1.67610576
121Nephronophthisis (HP:0000090)1.67337483
122Amblyopia (HP:0000646)1.65938011
123Rectal fistula (HP:0100590)1.65830102
124Rectovaginal fistula (HP:0000143)1.65830102
125Bradycardia (HP:0001662)1.65134786
126Lissencephaly (HP:0001339)1.64188216
127Postaxial foot polydactyly (HP:0001830)1.61777819
128Epileptiform EEG discharges (HP:0011182)1.60948427
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.60079095
130Severe visual impairment (HP:0001141)1.59849551
131Growth hormone deficiency (HP:0000824)1.59321513
132Increased hepatocellular lipid droplets (HP:0006565)1.58752165
133X-linked dominant inheritance (HP:0001423)1.58380416
134Gastroesophageal reflux (HP:0002020)1.56843822
135Tongue fasciculations (HP:0001308)1.56648444
136Generalized hypotonia (HP:0001290)1.55732968
137Decreased activity of mitochondrial respiratory chain (HP:0008972)1.53920485
138Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.53920485
139Astigmatism (HP:0000483)1.52687729
140Abnormal lung lobation (HP:0002101)1.52252660
141Cerebral hypomyelination (HP:0006808)1.52075056
142Nasal speech (HP:0001611)1.51935761
143Heterochromia iridis (HP:0001100)1.51702856
144Abnormality of incisor morphology (HP:0011063)1.51307151
145Hypoplasia of the brainstem (HP:0002365)1.51223141
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.51223141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.43277432
2MAP4K23.40015299
3MAP2K73.10735299
4AKT32.65578884
5TRIM282.59705948
6MAP3K122.58690821
7SIK32.43747815
8PRPF4B2.35183647
9PLK22.31532196
10NTRK32.29864811
11MKNK22.25600821
12BMPR1B2.20091153
13MARK12.14141126
14ERBB32.12180796
15MAP3K42.09570496
16TSSK62.06784091
17SGK22.04469945
18TNIK1.99668156
19MKNK11.94169331
20MAPK131.81829824
21MINK11.69537258
22SGK2231.64853944
23SGK4941.64853944
24STK161.62079945
25CSNK1A1L1.58667722
26SRPK11.54077690
27BMPR21.54067694
28BCR1.53462979
29YES11.50184958
30EPHA41.38983125
31INSRR1.38053460
32CDK81.36647037
33ZAK1.31237465
34MST41.30528345
35MUSK1.30192758
36PLK31.29933704
37WEE11.26779650
38ADRBK21.26619975
39DYRK31.24557173
40PAK31.22310786
41BCKDK1.19946740
42MAPK151.18439869
43FRK1.15660327
44BRAF1.15530906
45NEK61.14647851
46NME11.11207770
47VRK11.09708946
48MYLK1.09598415
49PRKCG1.07954816
50SGK31.06680468
51DAPK11.06062175
52CCNB11.06033076
53DYRK21.04925108
54EPHA31.04208075
55NTRK21.03975333
56LIMK10.97667339
57PHKG10.92187105
58PHKG20.92187105
59STK240.91541946
60MAP2K40.90744238
61GRK70.82257488
62GRK10.81089188
63BRSK10.78920399
64NUAK10.76667461
65PNCK0.76549118
66GRK50.76408753
67PRKCE0.76319144
68STK38L0.73731783
69ARAF0.73168508
70CAMK2A0.72386811
71WNK30.72290507
72RPS6KA40.70700927
73PLK40.70250374
74BRSK20.69961112
75FER0.69047219
76RPS6KB10.68983494
77BUB10.68631626
78EIF2AK30.68060497
79OXSR10.67941884
80UHMK10.67857897
81KSR10.66599121
82PDK40.65327779
83PDK30.65327779
84CDK190.64968392
85CSNK1G30.64871152
86ERBB40.64796066
87ADRBK10.63743951
88PAK60.63490188
89EIF2AK10.63184518
90EPHB20.61660228
91DYRK1A0.61383804
92RPS6KA20.58944716
93CDK180.58939324
94CDK30.58592640
95CAMK2B0.58268230
96CDK50.56366179
97STK390.54810922
98OBSCN0.52908942
99TESK10.52580846
100PINK10.52130391
101EIF2AK20.51443437
102PTK2B0.50839968
103VRK20.50536368
104CSNK1G20.49902183
105DYRK1B0.48687020
106DAPK20.48386635
107MAPKAPK50.46315736
108RPS6KA50.45819331
109PBK0.45245584
110PDK20.45135237
111CDK140.44989706
112CSNK1A10.44805806
113RPS6KC10.44593152
114RPS6KL10.44593152
115CAMKK20.42880572
116LMTK20.42213601
117CDK150.41597014
118MAP3K50.39012226
119SGK10.38474293
120PRKG10.38450278
121AURKA0.38111638
122CAMK2D0.37564588
123TLK10.37410982
124PRKACA0.36443093
125NEK10.35431054
126ACVR1B0.33966730
127RPS6KA60.33117430
128CDK11A0.32882872
129CSNK1G10.32666131
130PKN10.32409629
131CAMK2G0.32249973
132PLK10.32169683
133CDC70.29389846

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.53062660
2Oxidative phosphorylation_Homo sapiens_hsa001903.47121847
3Synaptic vesicle cycle_Homo sapiens_hsa047213.23792984
4Collecting duct acid secretion_Homo sapiens_hsa049662.95114214
5Parkinsons disease_Homo sapiens_hsa050122.84772929
6Proteasome_Homo sapiens_hsa030502.64948066
7Steroid biosynthesis_Homo sapiens_hsa001002.24912163
8Huntingtons disease_Homo sapiens_hsa050162.24884675
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21067425
10Olfactory transduction_Homo sapiens_hsa047402.10633132
11Alzheimers disease_Homo sapiens_hsa050102.08572492
12Vibrio cholerae infection_Homo sapiens_hsa051102.02463831
13GABAergic synapse_Homo sapiens_hsa047272.00699566
14RNA polymerase_Homo sapiens_hsa030201.92160981
15Morphine addiction_Homo sapiens_hsa050321.88325703
16Phototransduction_Homo sapiens_hsa047441.86676155
17Serotonergic synapse_Homo sapiens_hsa047261.85911258
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82505047
19Circadian entrainment_Homo sapiens_hsa047131.80911895
20Taste transduction_Homo sapiens_hsa047421.79675921
21Butanoate metabolism_Homo sapiens_hsa006501.74743847
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68331964
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63340203
24Amphetamine addiction_Homo sapiens_hsa050311.62898581
25Dopaminergic synapse_Homo sapiens_hsa047281.61500295
26Glutamatergic synapse_Homo sapiens_hsa047241.51861150
27Propanoate metabolism_Homo sapiens_hsa006401.50325966
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42985499
29Cardiac muscle contraction_Homo sapiens_hsa042601.42380790
30Long-term potentiation_Homo sapiens_hsa047201.35737709
31Long-term depression_Homo sapiens_hsa047301.32568093
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27172005
33Basal transcription factors_Homo sapiens_hsa030221.24774750
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19295450
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18789789
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18221176
37Mismatch repair_Homo sapiens_hsa034301.17344530
38Cholinergic synapse_Homo sapiens_hsa047251.17086591
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13802836
40Cocaine addiction_Homo sapiens_hsa050301.11350619
41Protein export_Homo sapiens_hsa030601.11246897
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10588842
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09608475
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06947580
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06514613
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06435030
47Purine metabolism_Homo sapiens_hsa002301.05758436
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04719015
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02844390
50Homologous recombination_Homo sapiens_hsa034401.02181065
51Calcium signaling pathway_Homo sapiens_hsa040201.01712018
52Nucleotide excision repair_Homo sapiens_hsa034200.99787634
53Phagosome_Homo sapiens_hsa041450.98699829
54Nitrogen metabolism_Homo sapiens_hsa009100.98096513
55Axon guidance_Homo sapiens_hsa043600.96031197
56beta-Alanine metabolism_Homo sapiens_hsa004100.95498509
57Rheumatoid arthritis_Homo sapiens_hsa053230.94904988
58Circadian rhythm_Homo sapiens_hsa047100.94746985
59Pyrimidine metabolism_Homo sapiens_hsa002400.93953048
60Insulin secretion_Homo sapiens_hsa049110.93789851
61RNA degradation_Homo sapiens_hsa030180.91231627
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.89954724
63Peroxisome_Homo sapiens_hsa041460.89931856
64Spliceosome_Homo sapiens_hsa030400.89475649
65Sulfur metabolism_Homo sapiens_hsa009200.84974628
66Gap junction_Homo sapiens_hsa045400.78982482
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78444907
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.76813414
69Oocyte meiosis_Homo sapiens_hsa041140.75956441
70Fanconi anemia pathway_Homo sapiens_hsa034600.75681945
71Renin secretion_Homo sapiens_hsa049240.75643107
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74579315
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74451449
74Salivary secretion_Homo sapiens_hsa049700.73997610
75Selenocompound metabolism_Homo sapiens_hsa004500.73685653
76RNA transport_Homo sapiens_hsa030130.73663003
77Alcoholism_Homo sapiens_hsa050340.73614066
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73280986
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72993526
80Folate biosynthesis_Homo sapiens_hsa007900.71789155
81Base excision repair_Homo sapiens_hsa034100.69930297
82DNA replication_Homo sapiens_hsa030300.69303131
83Fatty acid elongation_Homo sapiens_hsa000620.68870275
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.68785126
85Chemical carcinogenesis_Homo sapiens_hsa052040.67170074
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63675403
87mRNA surveillance pathway_Homo sapiens_hsa030150.62832725
88Type I diabetes mellitus_Homo sapiens_hsa049400.62688066
89Glutathione metabolism_Homo sapiens_hsa004800.62452798
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62430002
91Tryptophan metabolism_Homo sapiens_hsa003800.61359424
92Melanoma_Homo sapiens_hsa052180.61325390
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61205979
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60999403
95Linoleic acid metabolism_Homo sapiens_hsa005910.60987348
96Arginine and proline metabolism_Homo sapiens_hsa003300.60935855
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60531494
98Oxytocin signaling pathway_Homo sapiens_hsa049210.60522919
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59773860
100Regulation of autophagy_Homo sapiens_hsa041400.59673902
101Non-homologous end-joining_Homo sapiens_hsa034500.58643228
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56544243
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56460944
104Ether lipid metabolism_Homo sapiens_hsa005650.55915521
105Melanogenesis_Homo sapiens_hsa049160.55281111
106Vitamin B6 metabolism_Homo sapiens_hsa007500.54955126
107Cell cycle_Homo sapiens_hsa041100.54908502
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53962646
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51997979
110ErbB signaling pathway_Homo sapiens_hsa040120.51593208
111Fatty acid metabolism_Homo sapiens_hsa012120.50963660
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50043603
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47951293
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47103683
115N-Glycan biosynthesis_Homo sapiens_hsa005100.46128329
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.45877542
117Wnt signaling pathway_Homo sapiens_hsa043100.45857713
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45457162
119Gastric acid secretion_Homo sapiens_hsa049710.45009545
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44807126
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44657683
122Retinol metabolism_Homo sapiens_hsa008300.42891326
123Tyrosine metabolism_Homo sapiens_hsa003500.42571896
124Pyruvate metabolism_Homo sapiens_hsa006200.42155000
125cAMP signaling pathway_Homo sapiens_hsa040240.38975862
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38463848
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37618907
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36629595
129Metabolic pathways_Homo sapiens_hsa011000.33093926
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.32733885
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30753469
132Dilated cardiomyopathy_Homo sapiens_hsa054140.30340621
133Colorectal cancer_Homo sapiens_hsa052100.30274594
134Endometrial cancer_Homo sapiens_hsa052130.29327850
135Ras signaling pathway_Homo sapiens_hsa040140.29199292
136MAPK signaling pathway_Homo sapiens_hsa040100.28372915
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28024438
138GnRH signaling pathway_Homo sapiens_hsa049120.27618899
139Arachidonic acid metabolism_Homo sapiens_hsa005900.26968038

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