WRBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.41302461
2chromatin remodeling at centromere (GO:0031055)4.76652233
3chaperone-mediated protein transport (GO:0072321)4.73332368
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.72455458
5DNA damage response, detection of DNA damage (GO:0042769)4.59661818
6establishment of integrated proviral latency (GO:0075713)4.59319547
7DNA double-strand break processing (GO:0000729)4.55974069
8regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.43731397
9CENP-A containing nucleosome assembly (GO:0034080)4.39695205
10negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.38454840
11negative regulation of ligase activity (GO:0051352)4.38454840
12L-serine metabolic process (GO:0006563)4.28671612
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.24438259
14ribosome assembly (GO:0042255)4.23907089
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.16165618
16IMP biosynthetic process (GO:0006188)4.15515174
17DNA replication checkpoint (GO:0000076)4.03233048
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.99513467
19regulation of cellular amino acid metabolic process (GO:0006521)3.94027533
20histone exchange (GO:0043486)3.90701249
21DNA strand elongation involved in DNA replication (GO:0006271)3.80818695
22regulation of helicase activity (GO:0051095)3.77626210
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.68047577
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.66888065
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.66888065
26signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.66888065
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65261873
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.65261873
29establishment of viral latency (GO:0019043)3.64516195
30signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.63614740
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.63614740
32mitotic metaphase plate congression (GO:0007080)3.63514469
33purine nucleobase biosynthetic process (GO:0009113)3.63310491
34DNA catabolic process, exonucleolytic (GO:0000738)3.59868144
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.59466712
36DNA strand elongation (GO:0022616)3.58131537
37DNA replication-independent nucleosome organization (GO:0034724)3.58054682
38DNA replication-independent nucleosome assembly (GO:0006336)3.58054682
39regulation of ubiquitin-protein transferase activity (GO:0051438)3.54549337
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.54160456
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.53997673
42regulation of mitotic spindle checkpoint (GO:1903504)3.53997673
43IMP metabolic process (GO:0046040)3.53691954
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.53508629
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.53508629
46rRNA modification (GO:0000154)3.51523218
47positive regulation of SMAD protein import into nucleus (GO:0060391)3.49753171
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.48513939
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.44085022
50negative regulation of sister chromatid segregation (GO:0033046)3.44085022
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.44085022
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.44085022
53negative regulation of mitotic sister chromatid segregation (GO:0033048)3.44085022
54positive regulation of ligase activity (GO:0051351)3.42609064
55regulation of ligase activity (GO:0051340)3.40442243
56negative regulation of chromosome segregation (GO:0051985)3.36449558
57protein neddylation (GO:0045116)3.28448452
58spliceosomal snRNP assembly (GO:0000387)3.25534987
59nucleobase biosynthetic process (GO:0046112)3.23954593
60mitotic spindle checkpoint (GO:0071174)3.23859134
61spindle checkpoint (GO:0031577)3.23514828
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22401609
63telomere maintenance via semi-conservative replication (GO:0032201)3.21795531
64cullin deneddylation (GO:0010388)3.20677547
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.17124849
66termination of RNA polymerase III transcription (GO:0006386)3.17124849
67nodal signaling pathway (GO:0038092)3.15575970
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13857356
69heterochromatin organization (GO:0070828)3.11790760
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.10751972
71primitive streak formation (GO:0090009)3.10148065
72cell cycle G1/S phase transition (GO:0044843)3.08061067
73G1/S transition of mitotic cell cycle (GO:0000082)3.08061067
74protein localization to kinetochore (GO:0034501)3.06351028
75protein deneddylation (GO:0000338)3.04110231
76female gonad development (GO:0008585)3.03188270
77mitotic spindle assembly checkpoint (GO:0007094)3.02606326
78negative regulation of protein ubiquitination (GO:0031397)3.02410980
79metaphase plate congression (GO:0051310)3.01544246
80protein maturation by protein folding (GO:0022417)3.00591048
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99973229
82transcription from mitochondrial promoter (GO:0006390)2.96795446
83pseudouridine synthesis (GO:0001522)2.96685256
84histone mRNA metabolic process (GO:0008334)2.95895434
85double-strand break repair via nonhomologous end joining (GO:0006303)2.95519357
86non-recombinational repair (GO:0000726)2.95519357
87tRNA aminoacylation for protein translation (GO:0006418)2.94633926
88spindle assembly checkpoint (GO:0071173)2.94584642
89protein targeting to mitochondrion (GO:0006626)2.94447898
90DNA replication-dependent nucleosome assembly (GO:0006335)2.94071769
91DNA replication-dependent nucleosome organization (GO:0034723)2.94071769
92negative regulation of mitosis (GO:0045839)2.92630146
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92206150
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92206150
95formation of translation preinitiation complex (GO:0001731)2.90034490
96DNA unwinding involved in DNA replication (GO:0006268)2.89646794
97regulation of cellular amine metabolic process (GO:0033238)2.89401738
98tRNA aminoacylation (GO:0043039)2.88581651
99amino acid activation (GO:0043038)2.88581651
100oxidative phosphorylation (GO:0006119)2.86984918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.46159905
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88792922
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.72022249
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.71286562
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59600669
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.40704619
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21920999
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91384607
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88942576
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87056469
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63590881
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57950261
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52041370
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.47833075
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.47412002
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.47412002
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.47412002
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39566669
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39446858
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38590097
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24434497
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23166176
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18294336
24NANOG_16153702_ChIP-ChIP_HESCs_Human2.16923931
25POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12370851
26ELK1_19687146_ChIP-ChIP_HELA_Human2.09905889
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04374588
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02209476
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97736012
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.95518952
31AR_21909140_ChIP-Seq_LNCAP_Human1.94493877
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92016697
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90517772
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.89796360
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89224456
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89026860
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.88896365
38FOXP3_21729870_ChIP-Seq_TREG_Human1.88149949
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87338453
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.87241515
41NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83685724
42VDR_23849224_ChIP-Seq_CD4+_Human1.81806538
43DCP1A_22483619_ChIP-Seq_HELA_Human1.76673749
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74760447
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74097310
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70061819
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69870020
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65036781
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63464814
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61579538
51TTF2_22483619_ChIP-Seq_HELA_Human1.58970974
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58348444
53GABP_19822575_ChIP-Seq_HepG2_Human1.55256159
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52643336
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50611808
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50574179
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47932696
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.46370667
59XRN2_22483619_ChIP-Seq_HELA_Human1.45212997
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.42684060
61NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39959733
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.37358628
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36302271
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34623372
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.33023034
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32856028
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.31841221
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31639903
69ZNF274_21170338_ChIP-Seq_K562_Hela1.25594937
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25130191
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24264341
72EWS_26573619_Chip-Seq_HEK293_Human1.24216505
73MYC_18940864_ChIP-ChIP_HL60_Human1.23371264
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21007698
75VDR_22108803_ChIP-Seq_LS180_Human1.18652588
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17582489
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07443562
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.05844391
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03106664
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01889466
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00238698
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97685475
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95921231
84SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94995872
85FUS_26573619_Chip-Seq_HEK293_Human0.93847965
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.92396708
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91731307
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90987533
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89215585
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88531249
91NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86222494
92P300_19829295_ChIP-Seq_ESCs_Human0.83137049
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83017878
94POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82540049
95NANOG_16518401_ChIP-PET_MESCs_Mouse0.82426108
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81559520
97TAF15_26573619_Chip-Seq_HEK293_Human0.80490448
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79531066
99IRF1_19129219_ChIP-ChIP_H3396_Human0.78172513
100EOMES_21245162_ChIP-Seq_HESCs_Human0.76404950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.36101365
2MP0008058_abnormal_DNA_repair4.05091851
3MP0004957_abnormal_blastocyst_morpholog3.94490751
4MP0003890_abnormal_embryonic-extraembry3.93159401
5MP0010094_abnormal_chromosome_stability3.48916455
6MP0008877_abnormal_DNA_methylation3.37766227
7MP0003111_abnormal_nucleus_morphology3.17455982
8MP0008057_abnormal_DNA_replication3.05808806
9MP0002254_reproductive_system_inflammat3.03469338
10MP0003941_abnormal_skin_development3.00485759
11MP0003077_abnormal_cell_cycle2.78558486
12MP0008932_abnormal_embryonic_tissue2.75535428
13MP0001188_hyperpigmentation2.62125027
14MP0006292_abnormal_olfactory_placode2.61787598
15MP0004133_heterotaxia2.30924874
16MP0003567_abnormal_fetal_cardiomyocyte2.25589487
17MP0003718_maternal_effect2.14153402
18MP0001730_embryonic_growth_arrest2.09697792
19MP0008007_abnormal_cellular_replicative2.02731552
20MP0009672_abnormal_birth_weight1.98024855
21MP0003119_abnormal_digestive_system1.94266377
22MP0010352_gastrointestinal_tract_polyps1.86513343
23MP0003806_abnormal_nucleotide_metabolis1.77828941
24MP0010030_abnormal_orbit_morphology1.72902887
25MP0003121_genomic_imprinting1.72394031
26MP0001293_anophthalmia1.66607292
27MP0000350_abnormal_cell_proliferation1.59167409
28MP0002163_abnormal_gland_morphology1.58998047
29MP0003186_abnormal_redox_activity1.56908580
30MP0003123_paternal_imprinting1.54232767
31MP0002102_abnormal_ear_morphology1.49501195
32MP0002736_abnormal_nociception_after1.45914136
33MP0002084_abnormal_developmental_patter1.43168756
34MP0003136_yellow_coat_color1.42830856
35MP0006035_abnormal_mitochondrial_morpho1.42652627
36MP0001672_abnormal_embryogenesis/_devel1.40035274
37MP0005380_embryogenesis_phenotype1.40035274
38MP0003787_abnormal_imprinting1.39822433
39MP0005084_abnormal_gallbladder_morpholo1.38291699
40MP0008789_abnormal_olfactory_epithelium1.37243927
41MP0003937_abnormal_limbs/digits/tail_de1.35150036
42MP0002085_abnormal_embryonic_tissue1.33369895
43MP0003786_premature_aging1.30655423
44MP0010307_abnormal_tumor_latency1.26657454
45MP0001697_abnormal_embryo_size1.26583287
46MP0003122_maternal_imprinting1.25893377
47MP0002751_abnormal_autonomic_nervous1.25384831
48MP0005499_abnormal_olfactory_system1.23779154
49MP0005394_taste/olfaction_phenotype1.23779154
50MP0001529_abnormal_vocalization1.20013475
51MP0003011_delayed_dark_adaptation1.15609206
52MP0002080_prenatal_lethality1.14492139
53MP0006036_abnormal_mitochondrial_physio1.14478831
54MP0005670_abnormal_white_adipose1.10424620
55MP0004147_increased_porphyrin_level1.07182628
56MP0009697_abnormal_copulation1.05243813
57MP0003195_calcinosis1.04504688
58MP0003984_embryonic_growth_retardation1.03523372
59MP0002210_abnormal_sex_determination1.02873362
60MP0001286_abnormal_eye_development1.02349342
61MP0001177_atelectasis1.01122164
62MP0001485_abnormal_pinna_reflex1.00454970
63MP0002088_abnormal_embryonic_growth/wei1.00412446
64MP0009703_decreased_birth_body0.98991966
65MP0004197_abnormal_fetal_growth/weight/0.97439162
66MP0001929_abnormal_gametogenesis0.96099362
67MP0005075_abnormal_melanosome_morpholog0.94854701
68MP0000049_abnormal_middle_ear0.94287363
69MP0001145_abnormal_male_reproductive0.92226382
70MP0002111_abnormal_tail_morphology0.91410338
71MP0000653_abnormal_sex_gland0.90600948
72MP0000313_abnormal_cell_death0.90190447
73MP0008872_abnormal_physiological_respon0.89504534
74MP0002233_abnormal_nose_morphology0.85666663
75MP0002697_abnormal_eye_size0.85197143
76MP0002086_abnormal_extraembryonic_tissu0.84072176
77MP0000537_abnormal_urethra_morphology0.83780099
78MP0002938_white_spotting0.80542632
79MP0002160_abnormal_reproductive_system0.78777729
80MP0005379_endocrine/exocrine_gland_phen0.78725346
81MP0000490_abnormal_crypts_of0.78401661
82MP0000372_irregular_coat_pigmentation0.75352531
83MP0002796_impaired_skin_barrier0.74431152
84MP0005647_abnormal_sex_gland0.73153719
85MP0006054_spinal_hemorrhage0.72663934
86MP0004215_abnormal_myocardial_fiber0.72467728
87MP0006072_abnormal_retinal_apoptosis0.72271996
88MP0003137_abnormal_impulse_conducting0.71416173
89MP0003221_abnormal_cardiomyocyte_apopto0.71043446
90MP0003880_abnormal_central_pattern0.70456093
91MP0008770_decreased_survivor_rate0.69936224
92MP0001119_abnormal_female_reproductive0.65999277
93MP0000358_abnormal_cell_content/0.65487756
94MP0005395_other_phenotype0.65314134
95MP0005646_abnormal_pituitary_gland0.63256225
96MP0000428_abnormal_craniofacial_morphol0.63106854
97MP0001764_abnormal_homeostasis0.61058957
98MP0000579_abnormal_nail_morphology0.59559769
99MP0003861_abnormal_nervous_system0.59529132
100MP0003698_abnormal_male_reproductive0.59071212

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.33391836
2Colon cancer (HP:0003003)4.51102604
3Ependymoma (HP:0002888)3.64192595
4Multiple enchondromatosis (HP:0005701)3.45092875
5Meckel diverticulum (HP:0002245)3.38057557
6Abnormality of abdominal situs (HP:0011620)3.36612291
7Abdominal situs inversus (HP:0003363)3.36612291
8Acute necrotizing encephalopathy (HP:0006965)3.18185316
9Abnormality of the ileum (HP:0001549)3.16505717
10Birth length less than 3rd percentile (HP:0003561)3.06568876
11Abnormality of the preputium (HP:0100587)3.05859404
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.03566972
13Abnormality of chromosome stability (HP:0003220)3.02149616
14Hyperglycinemia (HP:0002154)2.98267926
15Acute encephalopathy (HP:0006846)2.97663082
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89131947
17Agnosia (HP:0010524)2.79676705
18Abnormal mitochondria in muscle tissue (HP:0008316)2.76659608
19Abnormality of glycine metabolism (HP:0010895)2.74979732
20Abnormality of serine family amino acid metabolism (HP:0010894)2.74979732
21Chromsome breakage (HP:0040012)2.74748925
22Abnormality of serum amino acid levels (HP:0003112)2.68575349
23Increased CSF lactate (HP:0002490)2.66346559
24Spastic diplegia (HP:0001264)2.57055259
25Septo-optic dysplasia (HP:0100842)2.56520536
26Microvesicular hepatic steatosis (HP:0001414)2.56195344
27Stenosis of the external auditory canal (HP:0000402)2.56080606
28Abnormality of the astrocytes (HP:0100707)2.49047236
29Astrocytoma (HP:0009592)2.49047236
30Absent radius (HP:0003974)2.46343392
31Progressive macrocephaly (HP:0004481)2.45819711
32Glioma (HP:0009733)2.44254686
33Horseshoe kidney (HP:0000085)2.44189592
34Aplasia involving forearm bones (HP:0009822)2.43162592
35Absent forearm bone (HP:0003953)2.43162592
36Rhabdomyosarcoma (HP:0002859)2.42107549
37Abnormal hair whorl (HP:0010721)2.41530653
38Hyperglycinuria (HP:0003108)2.39564741
39Cerebral edema (HP:0002181)2.38804778
40Mitochondrial inheritance (HP:0001427)2.36814793
41Neoplasm of the adrenal gland (HP:0100631)2.31993787
42Small intestinal stenosis (HP:0012848)2.26971333
43Duodenal stenosis (HP:0100867)2.26971333
44Increased hepatocellular lipid droplets (HP:0006565)2.25388835
45Fused cervical vertebrae (HP:0002949)2.23627992
46Nephroblastoma (Wilms tumor) (HP:0002667)2.22129974
47Increased serum lactate (HP:0002151)2.19409432
48Type I transferrin isoform profile (HP:0003642)2.16889710
49Increased serum pyruvate (HP:0003542)2.16162886
50Medulloblastoma (HP:0002885)2.16092297
51Embryonal renal neoplasm (HP:0011794)2.14622277
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13748946
53Abnormality of alanine metabolism (HP:0010916)2.13748946
54Hyperalaninemia (HP:0003348)2.13748946
55Abnormal lung lobation (HP:0002101)2.12156839
56Methylmalonic aciduria (HP:0012120)2.09428994
57Bilateral microphthalmos (HP:0007633)2.08073711
58Abnormality of the duodenum (HP:0002246)2.07982215
59Methylmalonic acidemia (HP:0002912)2.07550091
60Abnormality of the septum pellucidum (HP:0007375)2.05164145
61Triphalangeal thumb (HP:0001199)2.03256004
62Absent septum pellucidum (HP:0001331)2.02374765
63Hypoglycemic seizures (HP:0002173)2.01712877
64Supernumerary spleens (HP:0009799)2.01360150
65Hepatocellular necrosis (HP:0001404)1.99627326
66Carpal bone hypoplasia (HP:0001498)1.99389918
67Lactic acidosis (HP:0003128)1.98862495
68Respiratory difficulties (HP:0002880)1.98077109
69Abnormality of the fetal cardiovascular system (HP:0010948)1.96881815
70Abnormal umbilical cord blood vessels (HP:0011403)1.96881815
71Single umbilical artery (HP:0001195)1.96881815
72Lipid accumulation in hepatocytes (HP:0006561)1.96352567
73Cerebral hypomyelination (HP:0006808)1.94709900
74Abnormality of methionine metabolism (HP:0010901)1.94036597
75Ectopic kidney (HP:0000086)1.93524285
76Clubbing of toes (HP:0100760)1.91046883
77Cortical dysplasia (HP:0002539)1.90165026
78Abnormality of the umbilical cord (HP:0010881)1.89923152
79Reticulocytopenia (HP:0001896)1.89284325
80Nasal speech (HP:0001611)1.88418244
81Neoplasm of the colon (HP:0100273)1.87218424
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86628850
83Abnormality of glycolysis (HP:0004366)1.84793831
84Anal atresia (HP:0002023)1.84548428
85Hepatic necrosis (HP:0002605)1.82653670
86Abnormality of the clitoris (HP:0000056)1.82403713
87Reduced antithrombin III activity (HP:0001976)1.80383369
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80180341
89Gonadotropin excess (HP:0000837)1.79711222
90Hypoglycemic coma (HP:0001325)1.78831736
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78383775
92Decreased muscle mass (HP:0003199)1.77574705
93Leukodystrophy (HP:0002415)1.75524773
94Breast carcinoma (HP:0003002)1.75376203
95Postnatal microcephaly (HP:0005484)1.74988912
96Generalized hypotonia (HP:0001290)1.74877822
97Aqueductal stenosis (HP:0002410)1.73144293
98Biliary tract neoplasm (HP:0100574)1.71902981
99Cellular immunodeficiency (HP:0005374)1.71234350
100Hypoplastic female external genitalia (HP:0012815)1.70691242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.99494863
2BUB13.96302682
3PBK3.36923455
4VRK23.22706293
5CDC73.06792726
6STK163.02135276
7TTK2.98285507
8SRPK12.93750518
9MKNK22.78777692
10MST42.62535385
11WNK32.55914267
12PLK32.50554542
13MKNK12.41580708
14ZAK2.24539075
15TAF12.21953006
16BRSK22.21695733
17TNIK2.00336462
18PDK21.93746182
19NME11.90464564
20EIF2AK31.87654925
21VRK11.86508386
22PLK41.76538645
23NEK11.67519898
24TRIM281.66482677
25PLK11.57711779
26ACVR1B1.56056158
27DYRK21.52848030
28NUAK11.34824640
29PASK1.34356944
30BRSK11.33955716
31CDK191.29230454
32NLK1.27361252
33WEE11.25197267
34NME21.23670281
35DYRK31.17843872
36OXSR11.10431734
37EIF2AK11.08926038
38ATR1.08688075
39WNK41.02571440
40ALK0.97829746
41STK390.91709635
42EIF2AK20.89212282
43STK40.85034841
44CHEK20.84722629
45PLK20.81572374
46KDR0.79221563
47FGFR10.77601176
48BMPR1B0.75211375
49PAK40.73890790
50CSNK1G10.73713071
51MAP3K80.70376011
52AURKB0.70264640
53BCKDK0.69326273
54BCR0.68643790
55ATM0.67860512
56TGFBR10.64433547
57TESK20.61873109
58DAPK10.61582565
59ERBB40.60221299
60GRK10.58724406
61CASK0.58459178
62PNCK0.57816095
63STK38L0.56496938
64CSNK1G20.55777425
65MAP3K40.55564473
66CHEK10.55045165
67CSNK2A10.53972499
68TIE10.53847482
69MAP3K100.53042454
70MELK0.51631395
71STK30.50783271
72CSNK1G30.50323173
73CSNK1E0.49542323
74MINK10.45579413
75CSNK2A20.42970691
76LATS20.42838308
77ERBB30.41971416
78CDK70.39244692
79BRAF0.37130657
80AURKA0.36896505
81UHMK10.35102205
82EGFR0.34010952
83STK100.33576897
84CDK20.32285214
85CDK10.32130495
86PRKCI0.31179644
87RPS6KA40.30347818
88CDK90.30066476
89PRKDC0.29999591
90BMX0.29328097
91EPHA40.28628830
92PAK10.28394533
93PRKCG0.26837171
94NEK20.26800369
95CSNK1A1L0.26588282
96MAP3K50.26251558
97DYRK1A0.25999926
98INSRR0.24781575
99RPS6KA50.23907096
100MAP4K20.23731728

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.39652760
2Mismatch repair_Homo sapiens_hsa034303.38771916
3DNA replication_Homo sapiens_hsa030303.38359911
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28379737
5RNA polymerase_Homo sapiens_hsa030202.78841908
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57716958
7Non-homologous end-joining_Homo sapiens_hsa034502.47874580
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.42382737
9Base excision repair_Homo sapiens_hsa034102.31186534
10Homologous recombination_Homo sapiens_hsa034402.30115573
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20954131
12RNA transport_Homo sapiens_hsa030132.18982432
13Parkinsons disease_Homo sapiens_hsa050122.01668491
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.99267993
15Oxidative phosphorylation_Homo sapiens_hsa001901.93477138
16Spliceosome_Homo sapiens_hsa030401.90861022
17Propanoate metabolism_Homo sapiens_hsa006401.90396428
18Ribosome_Homo sapiens_hsa030101.88614450
19Basal transcription factors_Homo sapiens_hsa030221.87004344
20One carbon pool by folate_Homo sapiens_hsa006701.86590865
21Fanconi anemia pathway_Homo sapiens_hsa034601.77828484
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76846606
23Pyruvate metabolism_Homo sapiens_hsa006201.75217959
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75060222
25RNA degradation_Homo sapiens_hsa030181.75035604
26Cell cycle_Homo sapiens_hsa041101.73146085
27Protein export_Homo sapiens_hsa030601.70429876
28Fatty acid elongation_Homo sapiens_hsa000621.60503725
29Huntingtons disease_Homo sapiens_hsa050161.58068270
30Pyrimidine metabolism_Homo sapiens_hsa002401.55736682
31Steroid biosynthesis_Homo sapiens_hsa001001.48766194
32Nucleotide excision repair_Homo sapiens_hsa034201.44781469
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41989330
34Selenocompound metabolism_Homo sapiens_hsa004501.37462208
35Biosynthesis of amino acids_Homo sapiens_hsa012301.37231118
36Carbon metabolism_Homo sapiens_hsa012001.36878028
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35594426
38Vitamin B6 metabolism_Homo sapiens_hsa007501.31111834
39Glutathione metabolism_Homo sapiens_hsa004801.23571216
40mRNA surveillance pathway_Homo sapiens_hsa030151.23085453
41Purine metabolism_Homo sapiens_hsa002301.21909914
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14997510
43Alzheimers disease_Homo sapiens_hsa050101.11625859
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91935000
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91076079
46beta-Alanine metabolism_Homo sapiens_hsa004100.89600947
47Oocyte meiosis_Homo sapiens_hsa041140.86040716
48Phototransduction_Homo sapiens_hsa047440.82524106
49p53 signaling pathway_Homo sapiens_hsa041150.80886184
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79371363
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72556433
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69029448
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66663115
54Metabolic pathways_Homo sapiens_hsa011000.66330084
55Folate biosynthesis_Homo sapiens_hsa007900.65320670
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65025319
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63754320
58Arginine and proline metabolism_Homo sapiens_hsa003300.63240570
59Fatty acid degradation_Homo sapiens_hsa000710.60356156
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59828883
61Tryptophan metabolism_Homo sapiens_hsa003800.58771422
62TGF-beta signaling pathway_Homo sapiens_hsa043500.56339184
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52199132
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51043211
65Vitamin digestion and absorption_Homo sapiens_hsa049770.49451017
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48694227
67Peroxisome_Homo sapiens_hsa041460.47563604
68Cardiac muscle contraction_Homo sapiens_hsa042600.46697960
69Fatty acid metabolism_Homo sapiens_hsa012120.45678550
70Retinol metabolism_Homo sapiens_hsa008300.45548493
71Wnt signaling pathway_Homo sapiens_hsa043100.44854917
72Epstein-Barr virus infection_Homo sapiens_hsa051690.44850761
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44057881
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39663535
75Tight junction_Homo sapiens_hsa045300.35420757
76Basal cell carcinoma_Homo sapiens_hsa052170.31580824
77Hippo signaling pathway_Homo sapiens_hsa043900.29881122
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28626434
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27696011
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26974932
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26892467
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.26815801
83Sulfur relay system_Homo sapiens_hsa041220.26704745
84Galactose metabolism_Homo sapiens_hsa000520.24667007
85Sulfur metabolism_Homo sapiens_hsa009200.23321265
86N-Glycan biosynthesis_Homo sapiens_hsa005100.21476820
87Lysine degradation_Homo sapiens_hsa003100.20130244
88Adherens junction_Homo sapiens_hsa045200.19249252
89Thyroid cancer_Homo sapiens_hsa052160.18749713
90Butanoate metabolism_Homo sapiens_hsa006500.16184335
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15989481
92Chemical carcinogenesis_Homo sapiens_hsa052040.15595546
93Caffeine metabolism_Homo sapiens_hsa002320.15443626
94Histidine metabolism_Homo sapiens_hsa003400.15367783
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15292552
96Tyrosine metabolism_Homo sapiens_hsa003500.14815327
97Fat digestion and absorption_Homo sapiens_hsa049750.14765819
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.13729090
99Ether lipid metabolism_Homo sapiens_hsa005650.10912381
100Starch and sucrose metabolism_Homo sapiens_hsa005000.08544233

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