WRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.40558872
2DNA replication checkpoint (GO:0000076)4.52131667
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39822993
4mitotic sister chromatid segregation (GO:0000070)4.35298458
5regulation of centriole replication (GO:0046599)4.30682830
6DNA strand elongation involved in DNA replication (GO:0006271)4.20247212
7DNA double-strand break processing (GO:0000729)4.15937493
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05800383
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05800383
10positive regulation of B cell differentiation (GO:0045579)4.03321979
11mitotic metaphase plate congression (GO:0007080)4.03288480
12regulation of DNA endoreduplication (GO:0032875)4.02395197
13DNA strand elongation (GO:0022616)4.01130832
14definitive hemopoiesis (GO:0060216)3.86768515
15metaphase plate congression (GO:0051310)3.84390597
16histone exchange (GO:0043486)3.84369121
17membrane disassembly (GO:0030397)3.83638653
18nuclear envelope disassembly (GO:0051081)3.83638653
19regulation of gamma-delta T cell differentiation (GO:0045586)3.81163915
20double-strand break repair via nonhomologous end joining (GO:0006303)3.78011224
21non-recombinational repair (GO:0000726)3.78011224
22spindle checkpoint (GO:0031577)3.75161162
23DNA replication initiation (GO:0006270)3.74627177
24antigen processing and presentation of endogenous antigen (GO:0019883)3.74591860
25regulation of gamma-delta T cell activation (GO:0046643)3.71899532
26DNA ligation (GO:0006266)3.70976449
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.70078924
28kinetochore assembly (GO:0051382)3.70052089
29mitotic spindle checkpoint (GO:0071174)3.66249601
30centriole replication (GO:0007099)3.64203196
31mitotic sister chromatid cohesion (GO:0007064)3.62977543
32positive regulation of histone H3-K4 methylation (GO:0051571)3.62832215
33* replication fork processing (GO:0031297)3.62052927
34negative regulation of mitotic sister chromatid separation (GO:2000816)3.61925806
35negative regulation of sister chromatid segregation (GO:0033046)3.61925806
36negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.61925806
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.61925806
38negative regulation of mitotic sister chromatid segregation (GO:0033048)3.61925806
39DNA replication-independent nucleosome organization (GO:0034724)3.61750671
40DNA replication-independent nucleosome assembly (GO:0006336)3.61750671
41negative regulation of chromosome segregation (GO:0051985)3.61684718
42regulation of centrosome cycle (GO:0046605)3.56864197
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.55528542
44regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55528542
45purine nucleobase biosynthetic process (GO:0009113)3.52281955
46regulation of chromosome segregation (GO:0051983)3.52217138
47nuclear pore complex assembly (GO:0051292)3.51790479
48mitotic G2/M transition checkpoint (GO:0044818)3.51399433
49synapsis (GO:0007129)3.50615201
50regulation of sister chromatid segregation (GO:0033045)3.46895164
51regulation of mitotic sister chromatid separation (GO:0010965)3.46895164
52regulation of mitotic sister chromatid segregation (GO:0033047)3.46895164
53DNA replication-dependent nucleosome assembly (GO:0006335)3.44570634
54DNA replication-dependent nucleosome organization (GO:0034723)3.44570634
55mitotic spindle assembly checkpoint (GO:0007094)3.43859590
56DNA strand renaturation (GO:0000733)3.43182354
57ribosome assembly (GO:0042255)3.41679971
58spindle assembly checkpoint (GO:0071173)3.40224353
59establishment of integrated proviral latency (GO:0075713)3.38848543
60IMP biosynthetic process (GO:0006188)3.36713877
61regulation of B cell differentiation (GO:0045577)3.36107154
62negative regulation of DNA recombination (GO:0045910)3.36083995
63somatic hypermutation of immunoglobulin genes (GO:0016446)3.34237375
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34237375
65* DNA geometric change (GO:0032392)3.33342419
66nucleobase biosynthetic process (GO:0046112)3.33204965
67regulation of centrosome duplication (GO:0010824)3.33143766
68resolution of meiotic recombination intermediates (GO:0000712)3.27229578
69pre-miRNA processing (GO:0031054)3.27126836
70establishment of chromosome localization (GO:0051303)3.26570221
71meiotic chromosome segregation (GO:0045132)3.25984584
72* DNA duplex unwinding (GO:0032508)3.25610950
73regulation of mitotic spindle checkpoint (GO:1903504)3.23985975
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23985975
75regulation of RNA export from nucleus (GO:0046831)3.22882029
76positive regulation of chromosome segregation (GO:0051984)3.22378990
77monoubiquitinated protein deubiquitination (GO:0035520)3.21946604
78chromosome segregation (GO:0007059)3.18712749
79negative regulation of DNA repair (GO:0045738)3.18092014
80* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17614588
81folic acid-containing compound biosynthetic process (GO:0009396)3.17369090
82kinetochore organization (GO:0051383)3.12220401
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.11485445
84positive regulation of natural killer cell differentiation (GO:0032825)3.11138238
85mitotic chromosome condensation (GO:0007076)3.10723023
86regulation of helicase activity (GO:0051095)3.10147278
87negative regulation of phagocytosis (GO:0050765)3.08809504
88double-strand break repair via homologous recombination (GO:0000724)3.07290234
89* DNA conformation change (GO:0071103)3.04976382
90recombinational repair (GO:0000725)3.04543846
91regulation of sister chromatid cohesion (GO:0007063)3.04468108
92ATP-dependent chromatin remodeling (GO:0043044)3.04206236
93IMP metabolic process (GO:0046040)3.03406348
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02202254
95negative T cell selection (GO:0043383)3.01530277
96pore complex assembly (GO:0046931)3.01344931
97nuclear pore organization (GO:0006999)3.01315925
98protein localization to kinetochore (GO:0034501)3.00908924
99positive regulation of histone methylation (GO:0031062)3.00314011
100mitotic G2 DNA damage checkpoint (GO:0007095)3.00121378
101telomere maintenance via telomere lengthening (GO:0010833)2.99906230
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99575539
103intra-S DNA damage checkpoint (GO:0031573)2.99105115
104protein localization to chromosome, centromeric region (GO:0071459)2.98362940
105DNA topological change (GO:0006265)2.95201124
106mucosal-associated lymphoid tissue development (GO:0048537)2.91377099
107Peyers patch development (GO:0048541)2.91377099
108megakaryocyte development (GO:0035855)2.90735760
109negative regulation of DNA-dependent DNA replication (GO:2000104)2.90108618
110leukocyte aggregation (GO:0070486)2.87776615
111negative regulation of cell killing (GO:0031342)2.87635085
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87635085
113NIK/NF-kappaB signaling (GO:0038061)2.87380532
114negative thymic T cell selection (GO:0045060)2.86655171
115positive regulation of granulocyte differentiation (GO:0030854)2.83435643
116embryonic hemopoiesis (GO:0035162)2.83214520
117cellular response to zinc ion (GO:0071294)2.83176011
118regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80126848
119necroptotic process (GO:0070266)2.78445788
120regulation of interleukin-12 biosynthetic process (GO:0045075)2.78260084
121myeloid dendritic cell activation (GO:0001773)2.78017540
122positive regulation by symbiont of host defense response (GO:0052509)2.76992584
123modulation by symbiont of host defense response (GO:0052031)2.76992584
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76992584
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76992584
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.76992584
127modulation by symbiont of host immune response (GO:0052553)2.76992584
128T cell homeostasis (GO:0043029)2.74526313
129histone mRNA catabolic process (GO:0071044)2.73914154
130regulation of B cell receptor signaling pathway (GO:0050855)2.71631601
131dosage compensation (GO:0007549)2.70727391
132regulation of histone H3-K9 methylation (GO:0051570)2.68927572
133negative regulation of B cell proliferation (GO:0030889)2.65531748
134positive thymic T cell selection (GO:0045059)2.64457002
135sister chromatid segregation (GO:0000819)2.61519114
136regulation of erythrocyte differentiation (GO:0045646)2.61506413
137myoblast migration (GO:0051451)2.59562608
138interferon-gamma production (GO:0032609)2.57905029
139hepatocyte apoptotic process (GO:0097284)2.56965946
140positive regulation of erythrocyte differentiation (GO:0045648)2.56777642
141T cell migration (GO:0072678)2.56401731
142neutrophil activation involved in immune response (GO:0002283)2.54098623
143negative regulation of erythrocyte differentiation (GO:0045647)2.53945650
144lymph node development (GO:0048535)2.53484416
145sister chromatid cohesion (GO:0007062)2.53273453
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53081619
147lymphocyte homeostasis (GO:0002260)2.50533982
148regulation of interferon-beta biosynthetic process (GO:0045357)2.50332171
149erythrocyte maturation (GO:0043249)2.50087121
150natural killer cell differentiation (GO:0001779)2.48326933
151neutrophil activation (GO:0042119)2.48056298
152JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47486635
153mitotic recombination (GO:0006312)2.47188335
154regulation of alpha-beta T cell proliferation (GO:0046640)2.47005913
155telomere maintenance via recombination (GO:0000722)2.46563043
156natural killer cell mediated cytotoxicity (GO:0042267)2.46141859
157natural killer cell mediated immunity (GO:0002228)2.46141859
158negative regulation of granulocyte differentiation (GO:0030853)2.45631919
159CENP-A containing nucleosome assembly (GO:0034080)2.44775145
160translesion synthesis (GO:0019985)2.44091517
161leukocyte homeostasis (GO:0001776)2.43604213
162ribosomal small subunit assembly (GO:0000028)2.42161598
163regulation of granulocyte differentiation (GO:0030852)2.40473232
164positive T cell selection (GO:0043368)2.40202941
165B cell receptor signaling pathway (GO:0050853)2.39992933
166regulation of necroptotic process (GO:0060544)2.38946516
167energy homeostasis (GO:0097009)2.38746279
168B cell homeostasis (GO:0001782)2.36752557
169positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.34102045
170DNA unwinding involved in DNA replication (GO:0006268)2.33929446
171positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.33342315
172positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33342315
173positive regulation of mitotic sister chromatid separation (GO:1901970)2.33342315
174T cell selection (GO:0045058)2.33230221
175telomere maintenance via semi-conservative replication (GO:0032201)2.32619395
176mature B cell differentiation (GO:0002335)2.31520798
177mitotic nuclear envelope disassembly (GO:0007077)2.30856883
178positive regulation of protein import into nucleus, translocation (GO:0033160)2.30263538
179chromatin remodeling at centromere (GO:0031055)2.30179607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.42411729
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.37538873
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.27058619
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.87040727
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.71974510
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42040176
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35659345
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.30343106
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20306172
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.99680890
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89950405
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.84161189
13GATA1_22025678_ChIP-Seq_K562_Human2.79620615
14SCL_19346495_ChIP-Seq_HPC-7_Human2.73945408
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.62709453
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.61891790
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55769545
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48210666
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46567739
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43785225
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.40998352
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40894024
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33655515
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29773834
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26628003
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.25571523
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16756229
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15459347
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12285520
30MYB_26560356_Chip-Seq_TH2_Human2.10693257
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09188747
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08789745
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07387001
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06081441
35MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01615876
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01390296
37RUNX_20019798_ChIP-Seq_JUKART_Human1.91210661
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.88080970
39MYB_26560356_Chip-Seq_TH1_Human1.86887312
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84575996
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83831739
42MYC_22102868_ChIP-Seq_BL_Human1.82221574
43SPI1_23547873_ChIP-Seq_NB4_Human1.82195198
44FUS_26573619_Chip-Seq_HEK293_Human1.78173890
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76939172
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76230901
47EWS_26573619_Chip-Seq_HEK293_Human1.75640012
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.73930438
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72989899
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70124015
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69275349
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65609017
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64914881
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63857732
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.61971218
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60066767
57MAF_26560356_Chip-Seq_TH1_Human1.59461913
58VDR_21846776_ChIP-Seq_THP-1_Human1.59072198
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57610201
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53259034
61* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51021895
62DCP1A_22483619_ChIP-Seq_HELA_Human1.50786771
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48235822
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48106329
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47886212
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45965034
67TTF2_22483619_ChIP-Seq_HELA_Human1.43613144
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42130579
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38586966
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38193743
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37405581
72VDR_24763502_ChIP-Seq_THP-1_Human1.36815996
73PU_27001747_Chip-Seq_BMDM_Mouse1.36396708
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.36219273
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.35280371
76UTX_26944678_Chip-Seq_JUKART_Human1.34144979
77TCF7_22412390_ChIP-Seq_EML_Mouse1.33844393
78ELK1_19687146_ChIP-ChIP_HELA_Human1.32285879
79GATA3_27048872_Chip-Seq_THYMUS_Human1.31648491
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30320414
81MYC_18940864_ChIP-ChIP_HL60_Human1.30086741
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29948496
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28280220
84AR_21909140_ChIP-Seq_LNCAP_Human1.27454764
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25386561
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23293361
87* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23041109
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21154746
89KDM5A_27292631_Chip-Seq_BREAST_Human1.21147097
90SPI1_23127762_ChIP-Seq_K562_Human1.19113775
91* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19019614
92VDR_22108803_ChIP-Seq_LS180_Human1.18281110
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16216827
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.15901138
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15675182
96IGF1R_20145208_ChIP-Seq_DFB_Human1.15491471
97XRN2_22483619_ChIP-Seq_HELA_Human1.15118707
98ZNF274_21170338_ChIP-Seq_K562_Hela1.15026920
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13946303
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13602436
101GABP_19822575_ChIP-Seq_HepG2_Human1.13034043
102* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11704549
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.11480498
104* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08408143
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.08398005
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07859376
107VDR_23849224_ChIP-Seq_CD4+_Human1.06187575
108EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05695055
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05601002
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05046223
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05002322
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04735837
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04577538
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04337042
115SOX2_16153702_ChIP-ChIP_HESCs_Human1.03198551
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.03173384
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01636900
118GATA3_26560356_Chip-Seq_TH2_Human1.00341883
119* SRF_21415370_ChIP-Seq_HL-1_Mouse1.00196026
120* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99857381
121TAF15_26573619_Chip-Seq_HEK293_Human0.99686507
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98205590
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97455842
124CIITA_25753668_ChIP-Seq_RAJI_Human0.95625498
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93091126
126FOXP3_21729870_ChIP-Seq_TREG_Human0.91862862
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91678590
128ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91388020
129P300_19829295_ChIP-Seq_ESCs_Human0.91055417
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91036099
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90158168
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.89491483
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88427843
134STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86814728
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86668397
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84559193
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84330544
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83668039
139MAF_26560356_Chip-Seq_TH2_Human0.83651047
140* SOX17_20123909_ChIP-Seq_XEN_Mouse0.83615042
141MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83391437
142IRF1_19129219_ChIP-ChIP_H3396_Human0.82208468
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81699892
144GATA1_19941826_ChIP-Seq_K562_Human0.81665628
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81084118
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78341870
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78284488
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78280668
149VDR_24787735_ChIP-Seq_THP-1_Human0.77936005
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77795896
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.77433398
152SMAD_19615063_ChIP-ChIP_OVARY_Human0.77180446
153* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76886914
154PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76755128
155GATA2_19941826_ChIP-Seq_K562_Human0.75984735
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.75735940
157FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.75115428
158NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75050085
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74144044
160CHD1_26751641_Chip-Seq_LNCaP_Human0.74033288
161ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.73820092
162GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73763625
163SALL4_22934838_ChIP-ChIP_CD34+_Human0.73056171
164PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73021225
165EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.72189178
166NCOR1_26117541_ChIP-Seq_K562_Human0.72018539
167TFEB_21752829_ChIP-Seq_HELA_Human0.71599007
168SOX9_26525672_Chip-Seq_HEART_Mouse0.71050885
169CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70770164
170KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.70201377
171KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.70201377
172KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.70201377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.41112385
2MP0001835_abnormal_antigen_presentation3.24418337
3MP0009697_abnormal_copulation3.03031548
4MP0002166_altered_tumor_susceptibility2.69535959
5MP0008057_abnormal_DNA_replication2.67092115
6MP0008932_abnormal_embryonic_tissue2.62937840
7MP0000685_abnormal_immune_system2.56940119
8MP0003890_abnormal_embryonic-extraembry2.52689494
9MP0005671_abnormal_response_to2.48699404
10MP0003763_abnormal_thymus_physiology2.36705322
11MP0005397_hematopoietic_system_phenotyp2.35190601
12MP0001545_abnormal_hematopoietic_system2.35190601
13MP0001800_abnormal_humoral_immune2.33410940
14MP0010094_abnormal_chromosome_stability2.33169551
15MP0002006_tumorigenesis2.28696809
16MP0003718_maternal_effect2.19352219
17MP0001790_abnormal_immune_system2.19082805
18MP0005387_immune_system_phenotype2.19082805
19MP0004808_abnormal_hematopoietic_stem2.18811161
20MP0002398_abnormal_bone_marrow2.17115495
21MP0000569_abnormal_digit_pigmentation2.13343470
22MP0002452_abnormal_antigen_presenting2.12810464
23MP0003786_premature_aging2.10584113
24MP0003436_decreased_susceptibility_to2.05335911
25MP0002723_abnormal_immune_serum2.02405090
26MP0002420_abnormal_adaptive_immunity2.01203477
27MP0009785_altered_susceptibility_to2.00684763
28MP0001819_abnormal_immune_cell2.00027118
29MP0003941_abnormal_skin_development1.99405483
30MP0005000_abnormal_immune_tolerance1.98341728
31MP0002419_abnormal_innate_immunity1.97021717
32MP0003656_abnormal_erythrocyte_physiolo1.96640543
33MP0003693_abnormal_embryo_hatching1.95138996
34MP0008995_early_reproductive_senescence1.94319956
35* MP0005025_abnormal_response_to1.90035021
36MP0005464_abnormal_platelet_physiology1.80271038
37MP0000716_abnormal_immune_system1.78575441
38MP0003077_abnormal_cell_cycle1.77734764
39MP0001730_embryonic_growth_arrest1.76578868
40MP0000689_abnormal_spleen_morphology1.75919036
41MP0005174_abnormal_tail_pigmentation1.75333538
42MP0001672_abnormal_embryogenesis/_devel1.74452912
43MP0005380_embryogenesis_phenotype1.74452912
44MP0000490_abnormal_crypts_of1.73137514
45MP0002722_abnormal_immune_system1.72606308
46MP0006054_spinal_hemorrhage1.72040127
47MP0001697_abnormal_embryo_size1.71847628
48MP0003937_abnormal_limbs/digits/tail_de1.70633171
49MP0002405_respiratory_system_inflammati1.70303758
50MP0006292_abnormal_olfactory_placode1.69953356
51MP0002148_abnormal_hypersensitivity_rea1.69012037
52MP0009333_abnormal_splenocyte_physiolog1.68439271
53MP0000703_abnormal_thymus_morphology1.67818292
54MP0002084_abnormal_developmental_patter1.63773017
55MP0003300_gastrointestinal_ulcer1.63320453
56MP0003111_abnormal_nucleus_morphology1.62556972
57MP0002429_abnormal_blood_cell1.61011218
58MP0010155_abnormal_intestine_physiology1.60191940
59MP0003984_embryonic_growth_retardation1.60184979
60MP0008058_abnormal_DNA_repair1.58622885
61MP0010307_abnormal_tumor_latency1.57783908
62MP0002088_abnormal_embryonic_growth/wei1.57367196
63MP0001293_anophthalmia1.55467242
64MP0010352_gastrointestinal_tract_polyps1.55021639
65MP0002138_abnormal_hepatobiliary_system1.54404384
66MP0002938_white_spotting1.53763004
67MP0009278_abnormal_bone_marrow1.46639741
68MP0002009_preneoplasia1.46145892
69MP0008007_abnormal_cellular_replicative1.44673160
70MP0002085_abnormal_embryonic_tissue1.44401218
71MP0004147_increased_porphyrin_level1.40499181
72MP0003724_increased_susceptibility_to1.40073086
73MP0002877_abnormal_melanocyte_morpholog1.37742922
74MP0004197_abnormal_fetal_growth/weight/1.36576861
75MP0001845_abnormal_inflammatory_respons1.35758567
76* MP0001853_heart_inflammation1.35429254
77MP0003567_abnormal_fetal_cardiomyocyte1.33496716
78MP0004947_skin_inflammation1.32548215
79* MP0002080_prenatal_lethality1.32042299
80MP0001873_stomach_inflammation1.29636501
81MP0003183_abnormal_peptide_metabolism1.29094153
82MP0001929_abnormal_gametogenesis1.28350606
83MP0002095_abnormal_skin_pigmentation1.27756170
84MP0000465_gastrointestinal_hemorrhage1.24811299
85MP0009672_abnormal_birth_weight1.24322567
86MP0000372_irregular_coat_pigmentation1.24106079
87MP0009703_decreased_birth_body1.23315946
88MP0002210_abnormal_sex_determination1.21680861
89MP0002697_abnormal_eye_size1.19059482
90* MP0002019_abnormal_tumor_incidence1.18929379
91MP0003866_abnormal_defecation1.15847023
92MP0003868_abnormal_feces_composition1.14364864
93MP0006072_abnormal_retinal_apoptosis1.14295019
94MP0006035_abnormal_mitochondrial_morpho1.12983421
95MP0003121_genomic_imprinting1.12435677
96MP0005076_abnormal_cell_differentiation1.11905911
97MP0003303_peritoneal_inflammation1.11402665
98MP0001286_abnormal_eye_development1.10788646
99MP0008877_abnormal_DNA_methylation1.08553587
100MP0010030_abnormal_orbit_morphology1.07711152
101MP0003385_abnormal_body_wall1.07340960
102MP0002233_abnormal_nose_morphology1.04060376
103MP0001145_abnormal_male_reproductive1.03334276
104MP0000858_altered_metastatic_potential1.01153099
105MP0000428_abnormal_craniofacial_morphol1.00316127
106MP0009764_decreased_sensitivity_to0.99789851
107MP0000653_abnormal_sex_gland0.99712292
108MP0003448_altered_tumor_morphology0.97636557
109MP0005310_abnormal_salivary_gland0.96015071
110MP0002111_abnormal_tail_morphology0.95396353
111MP0002132_abnormal_respiratory_system0.94905983
112MP0000358_abnormal_cell_content/0.94664422
113MP0008469_abnormal_protein_level0.94533005
114MP0005075_abnormal_melanosome_morpholog0.94508102
115MP0003787_abnormal_imprinting0.92824336
116MP0003935_abnormal_craniofacial_develop0.90461296
117MP0001533_abnormal_skeleton_physiology0.90329093
118MP0001299_abnormal_eye_distance/0.89962349
119MP0001915_intracranial_hemorrhage0.88190923
120MP0005395_other_phenotype0.88171540
121MP0003943_abnormal_hepatobiliary_system0.87271426
122* MP0000313_abnormal_cell_death0.85688878
123MP0001986_abnormal_taste_sensitivity0.85597975
124MP0003119_abnormal_digestive_system0.85056907
125MP0003045_fibrosis0.85028856
126MP0002928_abnormal_bile_duct0.83853422
127MP0000350_abnormal_cell_proliferation0.83328069
128MP0001119_abnormal_female_reproductive0.82739325
129MP0000015_abnormal_ear_pigmentation0.81878617
130MP0004957_abnormal_blastocyst_morpholog0.81215924
131MP0010678_abnormal_skin_adnexa0.80032375
132MP0003755_abnormal_palate_morphology0.78766319
133MP0001661_extended_life_span0.77804232
134MP0002092_abnormal_eye_morphology0.77686326
135MP0003698_abnormal_male_reproductive0.76903863
136MP0005408_hypopigmentation0.76013922
137MP0002102_abnormal_ear_morphology0.75990348
138MP0005391_vision/eye_phenotype0.74886681
139MP0003566_abnormal_cell_adhesion0.74655069
140MP0000647_abnormal_sebaceous_gland0.74448007
141MP0009763_increased_sensitivity_to0.74233846
142MP0000432_abnormal_head_morphology0.72597313
143MP0001529_abnormal_vocalization0.72421238
144MP0002933_joint_inflammation0.72212336
145MP0002751_abnormal_autonomic_nervous0.71339821
146MP0001851_eye_inflammation0.71201064
147* MP0005384_cellular_phenotype0.70524446
148MP0002998_abnormal_bone_remodeling0.70405630
149MP0004264_abnormal_extraembryonic_tissu0.68084911
150MP0003699_abnormal_female_reproductive0.67869374
151MP0003861_abnormal_nervous_system0.65396028
152MP0002282_abnormal_trachea_morphology0.65167706
153MP0009765_abnormal_xenobiotic_induced0.64719202
154MP0005023_abnormal_wound_healing0.63952082
155MP0006082_CNS_inflammation0.63610692
156MP0003221_abnormal_cardiomyocyte_apopto0.62122130
157MP0002234_abnormal_pharynx_morphology0.62117728
158MP0002060_abnormal_skin_morphology0.62093396
159MP0005253_abnormal_eye_physiology0.61752492
160MP0005220_abnormal_exocrine_pancreas0.60724057
161MP0003123_paternal_imprinting0.60497550
162MP0002160_abnormal_reproductive_system0.59896123
163MP0006036_abnormal_mitochondrial_physio0.59196409
164MP0002086_abnormal_extraembryonic_tissu0.59105077
165MP0001243_abnormal_dermal_layer0.58948749
166MP0005647_abnormal_sex_gland0.58894396
167MP0008770_decreased_survivor_rate0.58695836
168MP0000631_abnormal_neuroendocrine_gland0.58225262
169MP0000383_abnormal_hair_follicle0.57788298
170* MP0005621_abnormal_cell_physiology0.57701426
171MP0000427_abnormal_hair_cycle0.57638449
172MP0008789_abnormal_olfactory_epithelium0.57632478
173MP0000537_abnormal_urethra_morphology0.57473547
174MP0002254_reproductive_system_inflammat0.56527098

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.09878685
2Thrombocytosis (HP:0001894)3.82461421
3Embryonal renal neoplasm (HP:0011794)3.75865270
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.75482769
5Recurrent viral infections (HP:0004429)3.73513813
6Meckel diverticulum (HP:0002245)3.72293692
7Nephroblastoma (Wilms tumor) (HP:0002667)3.60937803
8Abnormality of the ileum (HP:0001549)3.60169464
9Chromsome breakage (HP:0040012)3.59593880
10Recurrent abscess formation (HP:0002722)3.43870589
11Abnormality of the preputium (HP:0100587)3.43365720
12Recurrent bronchitis (HP:0002837)3.42886746
13Chronic otitis media (HP:0000389)3.40974049
14Abnormality of the labia minora (HP:0012880)3.34327071
15Volvulus (HP:0002580)3.34233366
16Myositis (HP:0100614)3.29746953
17Acute myeloid leukemia (HP:0004808)3.29494835
18Recurrent fungal infections (HP:0002841)3.29149540
19Small intestinal stenosis (HP:0012848)3.24471693
20Duodenal stenosis (HP:0100867)3.24471693
21IgM deficiency (HP:0002850)3.19571305
22Recurrent bacterial skin infections (HP:0005406)3.14548583
23Abnormal lung lobation (HP:0002101)3.08887391
24T lymphocytopenia (HP:0005403)3.06373089
25Optic neuritis (HP:0100653)3.04651401
26Retrobulbar optic neuritis (HP:0100654)3.04651401
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97093429
28Abnormality of the duodenum (HP:0002246)2.95062803
29Rhabdomyosarcoma (HP:0002859)2.95008393
30Abnormality of T cell number (HP:0011839)2.93903984
31Periodontitis (HP:0000704)2.82329961
32Cellulitis (HP:0100658)2.80472452
33Intestinal atresia (HP:0011100)2.74592139
34Eczematoid dermatitis (HP:0000976)2.73884678
35Prolonged bleeding time (HP:0003010)2.73697328
36Sloping forehead (HP:0000340)2.72576288
37Colon cancer (HP:0003003)2.69478137
38Thyroiditis (HP:0100646)2.68884806
39Nasal polyposis (HP:0100582)2.66000854
40Orchitis (HP:0100796)2.65653822
41Aplastic anemia (HP:0001915)2.64238699
42Recurrent sinusitis (HP:0011108)2.63982403
43Elevated erythrocyte sedimentation rate (HP:0003565)2.63208178
44Meningitis (HP:0001287)2.62306937
45Increased nuchal translucency (HP:0010880)2.62077338
46Arterial thrombosis (HP:0004420)2.61133658
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.60976132
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.59626241
49Petechiae (HP:0000967)2.58883526
50Myelodysplasia (HP:0002863)2.57244105
51B lymphocytopenia (HP:0010976)2.56864404
52Abnormality of B cell number (HP:0010975)2.56864404
53Hypoplasia of the thymus (HP:0000778)2.55899988
54Autoimmune thrombocytopenia (HP:0001973)2.55322643
55Abnormality of chromosome stability (HP:0003220)2.53151445
56Ependymoma (HP:0002888)2.52149915
57Recurrent cutaneous fungal infections (HP:0011370)2.51413516
58Chronic mucocutaneous candidiasis (HP:0002728)2.51413516
59Abnormality of the prostate (HP:0008775)2.49189563
60Absent frontal sinuses (HP:0002688)2.48532788
61Agammaglobulinemia (HP:0004432)2.47983734
62Pancreatic islet-cell hyperplasia (HP:0004510)2.47829038
63Medulloblastoma (HP:0002885)2.46231550
64Abnormal platelet volume (HP:0011876)2.45455369
65Abnormality of T cells (HP:0002843)2.43002810
66Glioma (HP:0009733)2.41184940
67Abnormality of the carotid arteries (HP:0005344)2.40266280
68Panhypogammaglobulinemia (HP:0003139)2.39478522
69Recurrent skin infections (HP:0001581)2.38430457
70Poikilocytosis (HP:0004447)2.38084894
71Vasculitis (HP:0002633)2.37339820
72Prostate neoplasm (HP:0100787)2.34961170
73Ectopic kidney (HP:0000086)2.34567405
74Gingival bleeding (HP:0000225)2.33764923
75Papillary thyroid carcinoma (HP:0002895)2.33299950
76Absent radius (HP:0003974)2.33134387
77Leukocytosis (HP:0001974)2.32308850
78Mediastinal lymphadenopathy (HP:0100721)2.31559340
79Epistaxis (HP:0000421)2.29114667
80Bronchitis (HP:0012387)2.28418025
81Neoplasm of the colon (HP:0100273)2.28207611
82Recurrent gram-negative bacterial infections (HP:0005420)2.27540886
83Cafe-au-lait spot (HP:0000957)2.24649003
84Acanthocytosis (HP:0001927)2.24545240
85Gastrointestinal infarctions (HP:0005244)2.21318414
86Chronic sinusitis (HP:0011109)2.20957426
87Keratoconjunctivitis sicca (HP:0001097)2.20483845
88Triphalangeal thumb (HP:0001199)2.20447890
89Cortical dysplasia (HP:0002539)2.18559853
90Lymphopenia (HP:0001888)2.16380843
91Astrocytoma (HP:0009592)2.15439490
92Abnormality of the astrocytes (HP:0100707)2.15439490
93Aplasia/Hypoplasia of the sternum (HP:0006714)2.15264188
94Pustule (HP:0200039)2.14809913
95Eosinophilia (HP:0001880)2.14807579
96Aplasia involving forearm bones (HP:0009822)2.13753847
97Absent forearm bone (HP:0003953)2.13753847
98Osteomyelitis (HP:0002754)2.13752125
99Biliary tract neoplasm (HP:0100574)2.13168894
100Clubbing of toes (HP:0100760)2.12975909
101Obstructive lung disease (HP:0006536)2.11752709
102Chronic obstructive pulmonary disease (HP:0006510)2.11752709
103Prominent nose (HP:0000448)2.10255419
104IgA deficiency (HP:0002720)2.08634649
105Abnormality of cells of the lymphoid lineage (HP:0012140)2.08335430
106Lymphoma (HP:0002665)2.08100533
107Embryonal neoplasm (HP:0002898)2.08089788
108Abnormality of T cell physiology (HP:0011840)2.08086127
109Deep philtrum (HP:0002002)2.07765860
110Acute lymphatic leukemia (HP:0006721)2.07628117
111IgG deficiency (HP:0004315)2.07616500
112Increased mean platelet volume (HP:0011877)2.06489519
113Abnormality of eosinophils (HP:0001879)2.05903619
114Pulmonary infiltrates (HP:0002113)2.05172392
115Long eyelashes (HP:0000527)2.04711586
116Abnormality of the nasal mucosa (HP:0000433)2.04312840
117Recurrent pneumonia (HP:0006532)2.03855628
118Encephalitis (HP:0002383)2.02821422
119Lip pit (HP:0100267)2.02260806
120Clitoromegaly (HP:0000057)2.01793479
121Truncal obesity (HP:0001956)2.01141469
122Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01005850
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00923896
124Severe combined immunodeficiency (HP:0004430)2.00318118
125Keratoconjunctivitis (HP:0001096)1.98769670
126Bronchiectasis (HP:0002110)1.98491933
127Birth length less than 3rd percentile (HP:0003561)1.97825899
128Combined immunodeficiency (HP:0005387)1.96005408
129Neoplasm of striated muscle (HP:0009728)1.93674785
130Thyroid carcinoma (HP:0002890)1.92103592
131Reticulocytopenia (HP:0001896)1.89464486
132Overlapping toe (HP:0001845)1.88921756
133Arteriovenous malformation (HP:0100026)1.88381236
134Leukopenia (HP:0001882)1.88131828
135Neoplasm of the adrenal cortex (HP:0100641)1.87689987
136Choanal atresia (HP:0000453)1.87680632
137Inflammation of the large intestine (HP:0002037)1.85604327
138Duplicated collecting system (HP:0000081)1.85314149
139Impaired platelet aggregation (HP:0003540)1.84080796
140Abnormal platelet function (HP:0011869)1.84080796
141Hypochromic microcytic anemia (HP:0004840)1.84009968
142Autoimmune hemolytic anemia (HP:0001890)1.83942215
143Hypoplastic labia majora (HP:0000059)1.83802355
144Abnormality of methionine metabolism (HP:0010901)1.83730177
145Gingivitis (HP:0000230)1.83143184
146Gonadotropin excess (HP:0000837)1.82585743
147* Ovarian neoplasm (HP:0100615)1.81314817
148Missing ribs (HP:0000921)1.80222796
149Abnormal biliary tract morphology (HP:0012440)1.79674786
150Abnormality of DNA repair (HP:0003254)1.77188800
151Oligodactyly (hands) (HP:0001180)1.76376676
152Microvesicular hepatic steatosis (HP:0001414)1.75220874
153Gastrointestinal atresia (HP:0002589)1.72274063
154Long clavicles (HP:0000890)1.71642263
155Abnormality of cochlea (HP:0000375)1.70689931
156Short middle phalanx of the 5th finger (HP:0004220)1.70038311
157Aqueductal stenosis (HP:0002410)1.69256036
158* Neoplasm of the small intestine (HP:0100833)1.67374367
159Abnormality of homocysteine metabolism (HP:0010919)1.67350575
160Homocystinuria (HP:0002156)1.67350575
161Abnormality of the labia majora (HP:0012881)1.67273488
162Skull defect (HP:0001362)1.66724592
163Tubulointerstitial nephritis (HP:0001970)1.64172977
164Abnormality of chromosome segregation (HP:0002916)1.63151181
165Sandal gap (HP:0001852)1.60941123
166Renal cortical cysts (HP:0000803)1.60235681
167Central scotoma (HP:0000603)1.59387143
168Horseshoe kidney (HP:0000085)1.58912735
169Breast carcinoma (HP:0003002)1.58320738
170Capillary hemangiomas (HP:0005306)1.58112538
171Abnormality of the parathyroid morphology (HP:0011766)1.57153202
172Uterine neoplasm (HP:0010784)1.56437865
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56032567
174Bifid tongue (HP:0010297)1.55310091
175Astigmatism (HP:0000483)1.54279976
176Abnormality of endocrine pancreas physiology (HP:0012093)1.52954720
177Abnormality of the pancreatic islet cells (HP:0006476)1.52954720
178Hypoplastic pelvis (HP:0008839)1.52561374
179Dandy-Walker malformation (HP:0001305)1.52447562
180Abnormality of the clitoris (HP:0000056)1.52332871
181Gastrointestinal carcinoma (HP:0002672)1.49790163
182Malignant gastrointestinal tract tumors (HP:0006749)1.49790163
183Neoplasm of the adrenal gland (HP:0100631)1.49371478
184Neoplasm of the rectum (HP:0100743)1.49273919
185Abnormality of the renal collecting system (HP:0004742)1.46291202
186Carpal bone hypoplasia (HP:0001498)1.45961755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.24094807
2MKNK23.21019382
3SRPK13.14323889
4MKNK12.97970346
5BUB12.89913292
6JAK32.83659446
7IRAK42.69279607
8CDC72.52704950
9EIF2AK32.50103710
10TAOK32.40490917
11MAP3K142.31593832
12TSSK62.31065185
13TXK2.29353390
14PLK32.28197538
15MST42.25484192
16NEK12.22181250
17PBK2.17274843
18MAP3K102.10213401
19STK102.07152043
20BTK1.96905905
21TYK21.93278748
22CAMK1D1.88432677
23TEC1.80693097
24KIT1.77190790
25CDK121.75742390
26PIM11.70563895
27TLK11.69586160
28NME21.66987860
29PNCK1.64909716
30STK31.63255902
31RPS6KA41.62094605
32NEK21.54610155
33JAK11.52454401
34TNIK1.48134939
35EEF2K1.45374653
36BMPR1B1.43442043
37IKBKE1.43025644
38IKBKB1.42906747
39CAMK1G1.40066296
40IRAK31.38120473
41TAF11.36090604
42TBK11.35799397
43FLT31.35583233
44NUAK11.35165828
45STK41.33764767
46CCNB11.32827377
47CHUK1.32368406
48TRIM281.31588592
49LATS11.30930864
50NEK91.29509707
51CSF1R1.29290042
52SYK1.28052129
53ATR1.27131210
54CDK61.20481339
55ITK1.17577659
56FGFR31.15864308
57VRK11.13184559
58ZAK1.12131108
59EIF2AK11.09796157
60ZAP701.07315837
61VRK21.06759739
62LCK1.05504643
63MELK1.05034354
64CDK91.05021221
65TRPM71.04482838
66BRSK21.01620443
67WNK31.01144591
68JAK21.01079445
69ACVR1B1.00774599
70STK38L1.00553575
71MAP3K130.99665075
72CSK0.96573612
73PLK20.92778416
74CDK40.86439073
75AURKB0.86371191
76LYN0.86025436
77HCK0.82646133
78AKT30.82272370
79BRSK10.82141345
80* ATM0.81973618
81RPS6KB20.81639019
82FGFR10.80977548
83MAP3K40.80690900
84NLK0.79403939
85FRK0.76540102
86STK240.76441986
87DYRK30.75518279
88PLK40.74556830
89RPS6KA60.74525079
90SCYL20.74501697
91RPS6KA50.74227689
92MAP4K20.72813162
93HIPK20.72635316
94CDK10.72545411
95EIF2AK20.72516002
96MAP2K30.72397451
97MAP3K80.71724719
98FGFR20.71149365
99TGFBR20.70633264
100PKN20.69834596
101MARK30.69121787
102RPS6KL10.66817582
103RPS6KC10.66817582
104YES10.66153237
105GRK60.65992224
106CLK10.65598929
107PASK0.64658667
108CDK20.64407396
109NME10.64374176
110INSRR0.63269104
111PIK3CA0.63129773
112FGFR40.61802730
113CHEK10.61692348
114LRRK20.61681150
115RAF10.61453383
116ERBB30.60600771
117RIPK40.59901321
118CDK30.59143910
119ALK0.58820457
120CHEK20.58708595
121BRD40.56951206
122MAPK110.56940045
123CSNK1G10.56610127
124BCR0.54986335
125RPS6KB10.54333048
126TTK0.53215066
127BLK0.52380350
128MAPKAPK20.51402139
129CSNK1E0.51299277
130WEE10.50855052
131CDK70.49867353
132PRKCQ0.48738194
133* PRKDC0.48358717
134SIK10.48029170
135PLK10.48019123
136CSNK2A20.46131092
137ABL10.45752225
138RPS6KA20.45458462
139SGK30.45122363
140SGK20.45035460
141TGFBR10.44976575
142CDK80.43647643
143PDK20.43308142
144CSNK2A10.37296023
145BRAF0.36128543
146MAPKAPK50.35133498
147PIK3CG0.34943688
148AURKA0.30433878
149GSK3B0.29776495
150MAPK140.27119764
151MAPK130.25935033
152KSR10.25794263

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.17211195
2Non-homologous end-joining_Homo sapiens_hsa034502.67341884
3DNA replication_Homo sapiens_hsa030302.63447955
4Primary immunodeficiency_Homo sapiens_hsa053402.58152190
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.42307145
6Leishmaniasis_Homo sapiens_hsa051402.16463842
7Protein export_Homo sapiens_hsa030602.14361586
8Measles_Homo sapiens_hsa051622.05821258
9RNA polymerase_Homo sapiens_hsa030201.97065136
10Fanconi anemia pathway_Homo sapiens_hsa034601.96669480
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.95928661
12Homologous recombination_Homo sapiens_hsa034401.92907478
13Antigen processing and presentation_Homo sapiens_hsa046121.87513696
14Propanoate metabolism_Homo sapiens_hsa006401.86493186
15Proteasome_Homo sapiens_hsa030501.85728382
16Systemic lupus erythematosus_Homo sapiens_hsa053221.82734473
17Hematopoietic cell lineage_Homo sapiens_hsa046401.82040654
18Herpes simplex infection_Homo sapiens_hsa051681.81808113
19Cell cycle_Homo sapiens_hsa041101.81129934
20B cell receptor signaling pathway_Homo sapiens_hsa046621.80366612
21Mismatch repair_Homo sapiens_hsa034301.77120062
22Base excision repair_Homo sapiens_hsa034101.73452482
23Osteoclast differentiation_Homo sapiens_hsa043801.66479938
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62537912
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56699407
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55109514
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.51498141
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49266399
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.48880243
30Hepatitis B_Homo sapiens_hsa051611.47770592
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38915169
32Viral carcinogenesis_Homo sapiens_hsa052031.38728609
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38373689
34Toxoplasmosis_Homo sapiens_hsa051451.38238641
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36210676
36Steroid biosynthesis_Homo sapiens_hsa001001.34095856
37Influenza A_Homo sapiens_hsa051641.33920769
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33651703
39Oocyte meiosis_Homo sapiens_hsa041141.33181238
40T cell receptor signaling pathway_Homo sapiens_hsa046601.30337580
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27060607
42Apoptosis_Homo sapiens_hsa042101.26485350
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25806526
44p53 signaling pathway_Homo sapiens_hsa041151.25335367
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25186185
46One carbon pool by folate_Homo sapiens_hsa006701.25046377
47Acute myeloid leukemia_Homo sapiens_hsa052211.23664516
48TNF signaling pathway_Homo sapiens_hsa046681.23156015
49Small cell lung cancer_Homo sapiens_hsa052221.21158224
50Chronic myeloid leukemia_Homo sapiens_hsa052201.20458618
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17806009
52Allograft rejection_Homo sapiens_hsa053301.17331121
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15539509
54Graft-versus-host disease_Homo sapiens_hsa053321.15482221
55Nucleotide excision repair_Homo sapiens_hsa034201.12717296
56Purine metabolism_Homo sapiens_hsa002301.11079047
57Pyruvate metabolism_Homo sapiens_hsa006201.08467168
58Malaria_Homo sapiens_hsa051441.08355136
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06167827
60HTLV-I infection_Homo sapiens_hsa051661.03439743
61RNA degradation_Homo sapiens_hsa030181.03351785
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99903156
63Selenocompound metabolism_Homo sapiens_hsa004500.98601033
64Platelet activation_Homo sapiens_hsa046110.97882374
65Pancreatic cancer_Homo sapiens_hsa052120.97057854
66Tuberculosis_Homo sapiens_hsa051520.95005296
67Staphylococcus aureus infection_Homo sapiens_hsa051500.94712400
68Chemokine signaling pathway_Homo sapiens_hsa040620.93714029
69Legionellosis_Homo sapiens_hsa051340.92884843
70Pertussis_Homo sapiens_hsa051330.92073439
71Lysine degradation_Homo sapiens_hsa003100.92045798
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91449847
73TGF-beta signaling pathway_Homo sapiens_hsa043500.90537006
74Epstein-Barr virus infection_Homo sapiens_hsa051690.86921799
75MicroRNAs in cancer_Homo sapiens_hsa052060.86548193
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86477776
77Thyroid cancer_Homo sapiens_hsa052160.86461079
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86218863
79ABC transporters_Homo sapiens_hsa020100.86146750
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.83946159
81Prolactin signaling pathway_Homo sapiens_hsa049170.83343096
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82254722
83Viral myocarditis_Homo sapiens_hsa054160.81302031
84Vitamin B6 metabolism_Homo sapiens_hsa007500.80583706
85Non-small cell lung cancer_Homo sapiens_hsa052230.78381740
86Hepatitis C_Homo sapiens_hsa051600.77918151
87Biosynthesis of amino acids_Homo sapiens_hsa012300.74386508
88Carbon metabolism_Homo sapiens_hsa012000.73180693
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72630374
90Spliceosome_Homo sapiens_hsa030400.69126517
91Prostate cancer_Homo sapiens_hsa052150.67928130
92FoxO signaling pathway_Homo sapiens_hsa040680.67423394
93Butanoate metabolism_Homo sapiens_hsa006500.66307322
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65053796
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64360134
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63237758
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63113759
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61506692
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61309559
100Shigellosis_Homo sapiens_hsa051310.60793911
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60165096
102RNA transport_Homo sapiens_hsa030130.59936974
103Autoimmune thyroid disease_Homo sapiens_hsa053200.59038183
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57274974
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57254905
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56576257
107Basal transcription factors_Homo sapiens_hsa030220.54179804
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53898820
109mRNA surveillance pathway_Homo sapiens_hsa030150.53092883
110Wnt signaling pathway_Homo sapiens_hsa043100.52753635
111Adherens junction_Homo sapiens_hsa045200.52430322
112Asthma_Homo sapiens_hsa053100.52393867
113Basal cell carcinoma_Homo sapiens_hsa052170.52017429
114Pyrimidine metabolism_Homo sapiens_hsa002400.50918009
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49866557
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48575069
117Insulin resistance_Homo sapiens_hsa049310.47412323
118Colorectal cancer_Homo sapiens_hsa052100.46221424
119Hedgehog signaling pathway_Homo sapiens_hsa043400.45120017
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.45057092
121Hippo signaling pathway_Homo sapiens_hsa043900.44705304
122Fatty acid metabolism_Homo sapiens_hsa012120.44602017
123Salmonella infection_Homo sapiens_hsa051320.43982630
124Other glycan degradation_Homo sapiens_hsa005110.42566401
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41921676
126Alcoholism_Homo sapiens_hsa050340.41693874
127Glutathione metabolism_Homo sapiens_hsa004800.38250405
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.38172903
129Huntingtons disease_Homo sapiens_hsa050160.38077223
130Metabolic pathways_Homo sapiens_hsa011000.37326960
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.36408209
132Ribosome_Homo sapiens_hsa030100.36355312
133Olfactory transduction_Homo sapiens_hsa047400.36340715
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36267431
135Notch signaling pathway_Homo sapiens_hsa043300.35129153
136N-Glycan biosynthesis_Homo sapiens_hsa005100.34520033
137Folate biosynthesis_Homo sapiens_hsa007900.33289508
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32896850
139Pathways in cancer_Homo sapiens_hsa052000.32612443
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30304150
141African trypanosomiasis_Homo sapiens_hsa051430.29722634
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28962386
143Fatty acid biosynthesis_Homo sapiens_hsa000610.27452709
144Peroxisome_Homo sapiens_hsa041460.25733380
145Fatty acid elongation_Homo sapiens_hsa000620.22235367
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.20793317
147Parkinsons disease_Homo sapiens_hsa050120.20276643
148Melanoma_Homo sapiens_hsa052180.19825030
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19362713
150Tight junction_Homo sapiens_hsa045300.17445581
151Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16368156
152Maturity onset diabetes of the young_Homo sapiens_hsa049500.15504596
153Circadian rhythm_Homo sapiens_hsa047100.12847044
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11262968
155Nitrogen metabolism_Homo sapiens_hsa009100.11205697
156Phototransduction_Homo sapiens_hsa047440.08690271
157mTOR signaling pathway_Homo sapiens_hsa041500.08380383
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07571259
159Inositol phosphate metabolism_Homo sapiens_hsa005620.06773592

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