WRNIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.16489416
2L-phenylalanine metabolic process (GO:0006558)6.16489416
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.16137428
4L-phenylalanine catabolic process (GO:0006559)6.16137428
5negative regulation of erythrocyte differentiation (GO:0045647)6.01399111
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.16128213
7aromatic amino acid family catabolic process (GO:0009074)5.11467474
8negative regulation of fibrinolysis (GO:0051918)4.99575131
9cysteine metabolic process (GO:0006534)4.92490884
10kynurenine metabolic process (GO:0070189)4.79921670
11alpha-linolenic acid metabolic process (GO:0036109)4.76334289
12bile acid biosynthetic process (GO:0006699)4.73979113
13sulfur amino acid catabolic process (GO:0000098)4.70048405
14definitive hemopoiesis (GO:0060216)4.60105611
15high-density lipoprotein particle remodeling (GO:0034375)4.59351584
16lysine metabolic process (GO:0006553)4.54614470
17lysine catabolic process (GO:0006554)4.54614470
18urea cycle (GO:0000050)4.49086524
19urea metabolic process (GO:0019627)4.49086524
20regulation of fibrinolysis (GO:0051917)4.48254421
21glyoxylate metabolic process (GO:0046487)4.46794705
22negative regulation of cholesterol transport (GO:0032375)4.46433172
23negative regulation of sterol transport (GO:0032372)4.46433172
24glutamate metabolic process (GO:0006536)4.34545899
25cellular ketone body metabolic process (GO:0046950)4.28312805
26regulation of cholesterol homeostasis (GO:2000188)4.24981063
27tryptophan catabolic process (GO:0006569)4.19084384
28indole-containing compound catabolic process (GO:0042436)4.19084384
29indolalkylamine catabolic process (GO:0046218)4.19084384
30regulation of protein activation cascade (GO:2000257)4.15384251
31protein carboxylation (GO:0018214)4.15055643
32peptidyl-glutamic acid carboxylation (GO:0017187)4.15055643
33glycine metabolic process (GO:0006544)4.09209474
34dicarboxylic acid biosynthetic process (GO:0043650)4.09094191
35bile acid metabolic process (GO:0008206)4.00962421
36tryptophan metabolic process (GO:0006568)3.99850109
37serine family amino acid catabolic process (GO:0009071)3.98693138
38nitrogen cycle metabolic process (GO:0071941)3.97960855
39poly(A)+ mRNA export from nucleus (GO:0016973)3.94989861
40regulation of mammary gland epithelial cell proliferation (GO:0033599)3.94616007
41DNA unwinding involved in DNA replication (GO:0006268)3.94322485
42cellular modified amino acid catabolic process (GO:0042219)3.92196010
43proline biosynthetic process (GO:0006561)3.87366872
44reverse cholesterol transport (GO:0043691)3.87014381
45regulation of complement activation (GO:0030449)3.86192087
46complement activation, alternative pathway (GO:0006957)3.84056042
47coenzyme catabolic process (GO:0009109)3.81734929
48alpha-amino acid catabolic process (GO:1901606)3.79545945
49regulation of cholesterol esterification (GO:0010872)3.78819044
50aromatic amino acid family metabolic process (GO:0009072)3.76451354
51ribosomal small subunit biogenesis (GO:0042274)3.72096409
52regulation of fatty acid beta-oxidation (GO:0031998)3.71760042
53protein-lipid complex remodeling (GO:0034368)3.68149475
54macromolecular complex remodeling (GO:0034367)3.68149475
55plasma lipoprotein particle remodeling (GO:0034369)3.68149475
56tyrosine metabolic process (GO:0006570)3.68015918
57ketone body metabolic process (GO:1902224)3.67817421
58regulation of translational fidelity (GO:0006450)3.66560006
592-oxoglutarate metabolic process (GO:0006103)3.64637444
60serine family amino acid metabolic process (GO:0009069)3.63622658
61regulation of early endosome to late endosome transport (GO:2000641)3.62215406
62acylglycerol homeostasis (GO:0055090)3.58420271
63triglyceride homeostasis (GO:0070328)3.58420271
64cellular amino acid catabolic process (GO:0009063)3.58402562
65homocysteine metabolic process (GO:0050667)3.58113367
66serine family amino acid biosynthetic process (GO:0009070)3.57320742
67pentose-phosphate shunt (GO:0006098)3.56221496
68nuclear pore complex assembly (GO:0051292)3.51222929
69imidazole-containing compound metabolic process (GO:0052803)3.46412352
70positive regulation of fatty acid beta-oxidation (GO:0032000)3.43565634
71phospholipid efflux (GO:0033700)3.42841991
72plasma lipoprotein particle assembly (GO:0034377)3.41928833
73one-carbon metabolic process (GO:0006730)3.40098969
74dicarboxylic acid catabolic process (GO:0043649)3.39720655
75regulation of triglyceride catabolic process (GO:0010896)3.38793479
76valine metabolic process (GO:0006573)3.38495336
77amino-acid betaine metabolic process (GO:0006577)3.35204653
78activation of Rac GTPase activity (GO:0032863)3.33572433
79fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.30635218
80intestinal cholesterol absorption (GO:0030299)3.30140576
81ethanol oxidation (GO:0006069)3.26268388
82aspartate family amino acid catabolic process (GO:0009068)3.24967953
83oxaloacetate metabolic process (GO:0006107)3.23850483
84bile acid and bile salt transport (GO:0015721)3.22962276
85cholesterol efflux (GO:0033344)3.22687151
86drug catabolic process (GO:0042737)3.22196985
87pinocytosis (GO:0006907)3.22123496
88protein-lipid complex assembly (GO:0065005)3.18676423
89cytolysis (GO:0019835)3.17609080
90mitotic chromosome condensation (GO:0007076)3.17176145
91sterol catabolic process (GO:0016127)3.11923855
92cholesterol catabolic process (GO:0006707)3.11923855
93Golgi transport vesicle coating (GO:0048200)3.11001593
94COPI coating of Golgi vesicle (GO:0048205)3.11001593
95plasma lipoprotein particle clearance (GO:0034381)3.10216597
96positive regulation of lipid catabolic process (GO:0050996)3.10071817
97regulation of glucose import in response to insulin stimulus (GO:2001273)3.09603008
98protein maturation by protein folding (GO:0022417)3.09407106
99negative regulation of cell size (GO:0045792)3.08839019
100glucose catabolic process (GO:0006007)3.08785169
101adherens junction assembly (GO:0034333)3.08401626
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07483072
103positive regulation of fatty acid biosynthetic process (GO:0045723)3.07087358
104benzene-containing compound metabolic process (GO:0042537)3.06896087
105complement activation, classical pathway (GO:0006958)3.05961674
106positive regulation of receptor recycling (GO:0001921)3.05817811
107cell-substrate adherens junction assembly (GO:0007045)3.05478539
108focal adhesion assembly (GO:0048041)3.05478539
109folic acid-containing compound biosynthetic process (GO:0009396)3.04939091
110low-density lipoprotein particle remodeling (GO:0034374)3.02698108
111embryonic process involved in female pregnancy (GO:0060136)3.02537663
1124-hydroxyproline metabolic process (GO:0019471)3.00840097
113protein retention in ER lumen (GO:0006621)2.99959625
114acetyl-CoA metabolic process (GO:0006084)2.99940244
115regulation of RNA export from nucleus (GO:0046831)2.98587853
116dosage compensation (GO:0007549)2.97167556
117hypotonic response (GO:0006971)2.96895904
118organic acid catabolic process (GO:0016054)2.95595181
119carboxylic acid catabolic process (GO:0046395)2.95595181
1203-UTR-mediated mRNA stabilization (GO:0070935)2.94080287
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92350697
122glutamine family amino acid biosynthetic process (GO:0009084)2.92221395
123viral transcription (GO:0019083)2.91547422
124indolalkylamine metabolic process (GO:0006586)2.90842233
125tricarboxylic acid metabolic process (GO:0072350)2.90519528
126short-chain fatty acid metabolic process (GO:0046459)2.90287989
127formation of translation preinitiation complex (GO:0001731)2.90120399
128succinate metabolic process (GO:0006105)2.89974056
129acute-phase response (GO:0006953)2.88165692
130regulation of nucleobase-containing compound transport (GO:0032239)2.85636436
131negative regulation of protein activation cascade (GO:2000258)2.85121894
132L-serine metabolic process (GO:0006563)2.83698872
133dicarboxylic acid metabolic process (GO:0043648)2.83167297
134mRNA stabilization (GO:0048255)2.83143930
135RNA stabilization (GO:0043489)2.83143930
136NADPH regeneration (GO:0006740)2.82630334
137cell-substrate junction assembly (GO:0007044)2.81784825
138spliceosomal tri-snRNP complex assembly (GO:0000244)2.81703736
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.77530789
140protein-DNA complex disassembly (GO:0032986)2.75365074
141nucleosome disassembly (GO:0006337)2.75365074
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74683796
143stress fiber assembly (GO:0043149)2.74561508
144regulation of glucocorticoid metabolic process (GO:0031943)2.74131513
145protein localization to endosome (GO:0036010)2.72879276
146pore complex assembly (GO:0046931)2.71069303
147desmosome organization (GO:0002934)2.69937083
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67905933
149translational termination (GO:0006415)2.67220552
150proline metabolic process (GO:0006560)2.66607825
151positive regulation of nuclease activity (GO:0032075)2.65075698
152cellular protein complex localization (GO:0034629)2.63256442
153corticosteroid receptor signaling pathway (GO:0031958)2.62904609
154nuclear pore organization (GO:0006999)2.61600841
155glucocorticoid receptor signaling pathway (GO:0042921)2.58722079
156regulation of histone H3-K27 methylation (GO:0061085)2.58533132
157nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55918100
158histone H2B ubiquitination (GO:0033523)2.54930478
159protein export from nucleus (GO:0006611)2.54723554
160positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54715712
161positive regulation of DNA-dependent DNA replication (GO:2000105)2.54222663
162epithelial cell-cell adhesion (GO:0090136)2.50384894
163cellular response to epidermal growth factor stimulus (GO:0071364)2.49898933
164regulation of response to osmotic stress (GO:0047484)2.49839024
165mitotic sister chromatid cohesion (GO:0007064)2.49661867
166protein localization to microtubule (GO:0035372)2.49591738
167modulation by symbiont of host cellular process (GO:0044068)2.49574667
168cellular hyperosmotic response (GO:0071474)2.49459235
169maternal placenta development (GO:0001893)2.48034592
170modulation by virus of host process (GO:0019054)2.47862365
171apoptotic process involved in morphogenesis (GO:0060561)2.47162723
172regulation of integrin activation (GO:0033623)2.44658117
173megakaryocyte development (GO:0035855)2.44530506
174regulation of translational termination (GO:0006449)2.43361225
175negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.42826404
176mitochondrial fusion (GO:0008053)2.40297419
177histone H3-K9 demethylation (GO:0033169)2.40132546
178translational elongation (GO:0006414)2.39991832
179planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38718420
180regulation of NFAT protein import into nucleus (GO:0051532)2.37849071
181negative regulation of fatty acid transport (GO:2000192)2.36430511
182ribosomal small subunit assembly (GO:0000028)2.34792440
183regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.33221561
184positive regulation of blood vessel endothelial cell migration (GO:0043536)2.32750124
185regulation of nuclease activity (GO:0032069)2.32379874
186pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.32340625
187establishment of apical/basal cell polarity (GO:0035089)2.31864724
188platelet aggregation (GO:0070527)2.31840291
189UV protection (GO:0009650)2.30955615
190regulation of superoxide anion generation (GO:0032928)2.30873386
191viral life cycle (GO:0019058)2.30599014
192protein complex disassembly (GO:0043241)2.30519649
193G1 DNA damage checkpoint (GO:0044783)2.30365051
194barbed-end actin filament capping (GO:0051016)2.29626212
195negative regulation of homotypic cell-cell adhesion (GO:0034111)2.29079383
196endoplasmic reticulum unfolded protein response (GO:0030968)2.28453342
197peptidyl-lysine dimethylation (GO:0018027)2.27722601
198regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.26373961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.08608626
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.29332707
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.55891883
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.65692537
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.25976816
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.07323849
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.59668953
8E2F7_22180533_ChIP-Seq_HELA_Human3.58436188
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56098407
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.02095487
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.01244853
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.65739473
13ZNF263_19887448_ChIP-Seq_K562_Human2.55668613
14CLOCK_20551151_ChIP-Seq_293T_Human2.47184522
15MYC_22102868_ChIP-Seq_BL_Human2.38887847
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33250414
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.31291689
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17191885
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06219622
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.00820438
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.91449106
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.90143742
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85841414
24LXR_22292898_ChIP-Seq_THP-1_Human1.84868547
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82763987
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.82149317
27GATA1_22025678_ChIP-Seq_K562_Human1.81705714
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78305445
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71701250
30* RARB_27405468_Chip-Seq_BRAIN_Mouse1.68898339
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68894518
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65683802
33SCL_19346495_ChIP-Seq_HPC-7_Human1.61076654
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59817917
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54056307
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52598379
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.52508832
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49078724
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48428542
40KDM2B_26808549_Chip-Seq_DND41_Human1.46227592
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43608243
42* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43417514
43TCF7_22412390_ChIP-Seq_EML_Mouse1.40454662
44VDR_24763502_ChIP-Seq_THP-1_Human1.37409562
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37314028
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37282419
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36850848
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.36668282
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35854701
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35145718
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32158196
52XRN2_22483619_ChIP-Seq_HELA_Human1.31717929
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31436906
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31426119
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31095575
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30465212
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30343471
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28089954
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.27849254
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27060529
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26845329
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25711149
63CREB1_26743006_Chip-Seq_LNCaP_Human1.25508357
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24607808
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19442630
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17966186
67KDM2B_26808549_Chip-Seq_K562_Human1.17023909
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15938716
69RACK7_27058665_Chip-Seq_MCF-7_Human1.15288349
70UTX_26944678_Chip-Seq_JUKART_Human1.14040765
71VDR_21846776_ChIP-Seq_THP-1_Human1.13193020
72GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.13165515
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.13058070
74* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11721521
75SMC4_20622854_ChIP-Seq_HELA_Human1.11388075
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10904433
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10894327
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10320643
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.10269313
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09291497
81ATF3_27146783_Chip-Seq_COLON_Human1.09129618
82AR_21909140_ChIP-Seq_LNCAP_Human1.08893535
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08828347
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08663565
85* HNF4A_19822575_ChIP-Seq_HepG2_Human1.07376712
86* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06441544
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06127350
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06020585
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04947725
90MAF_26560356_Chip-Seq_TH2_Human1.02994396
91GATA1_19941826_ChIP-Seq_K562_Human1.02910158
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02783817
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02704142
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02624861
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01546867
96* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01366310
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01202223
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00702501
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.00551975
100* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00312150
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00287703
102* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00259038
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00219593
104* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99982531
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99833913
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99596582
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99270740
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.96820263
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96757206
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95113728
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94791885
112* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93949153
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92645222
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92328553
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92192015
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90522267
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.88526108
118P68_20966046_ChIP-Seq_HELA_Human0.87685510
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85640367
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85408384
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.85226890
122* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84413152
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.83697563
124REST_21632747_ChIP-Seq_MESCs_Mouse0.82384788
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81965064
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81337580
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80356586
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.79966830
129EGR1_19374776_ChIP-ChIP_THP-1_Human0.79670378
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.78877519
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78570544
132* CHD1_26751641_Chip-Seq_LNCaP_Human0.78487337
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78459415
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77523292
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76895706
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76782330
137* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75255500
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74882322
139RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72951348
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.72887896
141DROSHA_22980978_ChIP-Seq_HELA_Human0.72207269
142* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.71783724
143* NCOR1_26117541_ChIP-Seq_K562_Human0.71677068
144* FOXP1_21924763_ChIP-Seq_HESCs_Human0.70960331
145MAF_26560356_Chip-Seq_TH1_Human0.70881108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.11033827
2MP0005360_urolithiasis6.23627289
3MP0005085_abnormal_gallbladder_physiolo5.50771097
4MP0005365_abnormal_bile_salt5.35719882
5MP0008875_abnormal_xenobiotic_pharmacok4.33187465
6MP0005451_abnormal_body_composition3.65482433
7MP0009840_abnormal_foam_cell3.13469525
8MP0010329_abnormal_lipoprotein_level3.13102893
9MP0003252_abnormal_bile_duct3.11908326
10MP0003806_abnormal_nucleotide_metabolis3.08418863
11MP0005464_abnormal_platelet_physiology3.02188727
12MP0005083_abnormal_biliary_tract3.02188387
13MP0004185_abnormal_adipocyte_glucose2.99991862
14MP0005409_darkened_coat_color2.90273505
15MP0001666_abnormal_nutrient_absorption2.66569522
16MP0003566_abnormal_cell_adhesion2.35541664
17MP0004859_abnormal_synaptic_plasticity2.30168999
18MP0004808_abnormal_hematopoietic_stem2.26474833
19MP0002396_abnormal_hematopoietic_system2.24961968
20MP0000678_abnormal_parathyroid_gland2.19456230
21MP0003868_abnormal_feces_composition2.18823311
22MP0005058_abnormal_lysosome_morphology2.18042670
23MP0003329_amyloid_beta_deposits2.17448566
24MP0005332_abnormal_amino_acid2.15341055
25MP0002909_abnormal_adrenal_gland2.08233402
26MP0005666_abnormal_adipose_tissue2.04979831
27MP0003705_abnormal_hypodermis_morpholog2.00008229
28MP0004233_abnormal_muscle_weight1.98144458
29MP0009379_abnormal_foot_pigmentation1.96808947
30MP0003195_calcinosis1.95486995
31MP0003111_abnormal_nucleus_morphology1.92982054
32MP0002796_impaired_skin_barrier1.90751524
33MP0000609_abnormal_liver_physiology1.88497075
34MP0002837_dystrophic_cardiac_calcinosis1.83417155
35MP0002822_catalepsy1.83403777
36MP0002118_abnormal_lipid_homeostasis1.81898971
37MP0003453_abnormal_keratinocyte_physiol1.76389078
38MP0001730_embryonic_growth_arrest1.70302744
39MP0005501_abnormal_skin_physiology1.68942671
40MP0010234_abnormal_vibrissa_follicle1.62670124
41MP0005375_adipose_tissue_phenotype1.61041284
42MP0004957_abnormal_blastocyst_morpholog1.60155896
43MP0002138_abnormal_hepatobiliary_system1.58666132
44MP0003191_abnormal_cellular_cholesterol1.56370465
45MP0005623_abnormal_meninges_morphology1.55300614
46MP0005584_abnormal_enzyme/coenzyme_acti1.53893208
47MP0000350_abnormal_cell_proliferation1.49931371
48MP0002877_abnormal_melanocyte_morpholog1.49465522
49MP0005319_abnormal_enzyme/_coenzyme1.47814359
50MP0000604_amyloidosis1.46886515
51MP0003300_gastrointestinal_ulcer1.43241689
52MP0005397_hematopoietic_system_phenotyp1.42931280
53MP0001545_abnormal_hematopoietic_system1.42931280
54MP0009278_abnormal_bone_marrow1.40364189
55MP0002089_abnormal_postnatal_growth/wei1.37393100
56MP0000465_gastrointestinal_hemorrhage1.37060533
57MP0002078_abnormal_glucose_homeostasis1.36021676
58MP0000733_abnormal_muscle_development1.34025786
59MP0008961_abnormal_basal_metabolism1.32514099
60MP0003635_abnormal_synaptic_transmissio1.31995119
61MP0003077_abnormal_cell_cycle1.29671241
62MP0001944_abnormal_pancreas_morphology1.29404187
63MP0002080_prenatal_lethality1.27896526
64MP0010630_abnormal_cardiac_muscle1.27660166
65MP0002086_abnormal_extraembryonic_tissu1.27510842
66MP0000681_abnormal_thyroid_gland1.23027547
67MP0003172_abnormal_lysosome_physiology1.21869118
68MP0009643_abnormal_urine_homeostasis1.20423915
69MP0008004_abnormal_stomach_pH1.19135756
70MP0005220_abnormal_exocrine_pancreas1.18483116
71MP0009780_abnormal_chondrocyte_physiolo1.16511232
72MP0003984_embryonic_growth_retardation1.16099228
73MP0008260_abnormal_autophagy1.14675050
74MP0004019_abnormal_vitamin_homeostasis1.14036298
75MP0001672_abnormal_embryogenesis/_devel1.12217755
76MP0005380_embryogenesis_phenotype1.12217755
77MP0001697_abnormal_embryo_size1.09008921
78MP0001851_eye_inflammation1.08991089
79MP0000537_abnormal_urethra_morphology1.08006945
80MP0003091_abnormal_cell_migration1.07902118
81MP0002063_abnormal_learning/memory/cond1.06930989
82MP0002088_abnormal_embryonic_growth/wei1.06801667
83MP0010094_abnormal_chromosome_stability1.05222137
84MP0005621_abnormal_cell_physiology1.05097327
85MP0009931_abnormal_skin_appearance1.04420296
86MP0000858_altered_metastatic_potential1.03530264
87MP0002060_abnormal_skin_morphology1.02168097
88MP0000013_abnormal_adipose_tissue1.02125059
89MP0000598_abnormal_liver_morphology1.01520270
90MP0000313_abnormal_cell_death1.01081959
91MP0003303_peritoneal_inflammation1.00924560
92MP0002009_preneoplasia1.00327749
93MP0008438_abnormal_cutaneous_collagen0.99493663
94MP0001915_intracranial_hemorrhage0.98769926
95MP0003693_abnormal_embryo_hatching0.98570121
96MP0005187_abnormal_penis_morphology0.98388156
97MP0001764_abnormal_homeostasis0.98212932
98MP0001216_abnormal_epidermal_layer0.97630735
99MP0004947_skin_inflammation0.96509515
100MP0008007_abnormal_cellular_replicative0.96181307
101MP0005023_abnormal_wound_healing0.95371903
102MP0004087_abnormal_muscle_fiber0.95337952
103MP0003283_abnormal_digestive_organ0.93747188
104MP0002249_abnormal_larynx_morphology0.93361454
105MP0010352_gastrointestinal_tract_polyps0.92191423
106MP0005636_abnormal_mineral_homeostasis0.91812446
107MP0005535_abnormal_body_temperature0.91203220
108MP0003763_abnormal_thymus_physiology0.90107896
109MP0005257_abnormal_intraocular_pressure0.90070283
110MP0000759_abnormal_skeletal_muscle0.89111013
111MP0002693_abnormal_pancreas_physiology0.88682486
112MP0009745_abnormal_behavioral_response0.86713048
113MP0004043_abnormal_pH_regulation0.86460499
114MP0005384_cellular_phenotype0.86048646
115MP0000639_abnormal_adrenal_gland0.85990185
116MP0001661_extended_life_span0.85553504
117MP0008872_abnormal_physiological_respon0.83521295
118MP0003123_paternal_imprinting0.82055819
119MP0008932_abnormal_embryonic_tissue0.81200145
120MP0000490_abnormal_crypts_of0.80171253
121MP0008874_decreased_physiological_sensi0.79630185
122MP0004272_abnormal_basement_membrane0.79311500
123MP0001346_abnormal_lacrimal_gland0.79208809
124MP0001968_abnormal_touch/_nociception0.78957713
125MP0001849_ear_inflammation0.77142678
126MP0009642_abnormal_blood_homeostasis0.76543500
127MP0006138_congestive_heart_failure0.76187460
128MP0005084_abnormal_gallbladder_morpholo0.76084636
129MP0002019_abnormal_tumor_incidence0.76013541
130MP0005448_abnormal_energy_balance0.75706448
131MP0003953_abnormal_hormone_level0.74095126
132MP0002085_abnormal_embryonic_tissue0.72412902
133MP0002925_abnormal_cardiovascular_devel0.72308147
134MP0005330_cardiomyopathy0.72257613
135MP0009672_abnormal_birth_weight0.71179878
136MP0003638_abnormal_response/metabolism_0.70513701
137MP0003315_abnormal_perineum_morphology0.70479712
138MP0004782_abnormal_surfactant_physiolog0.69654175
139MP0000703_abnormal_thymus_morphology0.68710083
140MP0000467_abnormal_esophagus_morphology0.68649056
141MP0002064_seizures0.67554437
142MP0004811_abnormal_neuron_physiology0.67466910
143MP0005076_abnormal_cell_differentiation0.67086914
144MP0006036_abnormal_mitochondrial_physio0.66668914
145MP0009333_abnormal_splenocyte_physiolog0.66628666
146MP0005165_increased_susceptibility_to0.66110649
147MP0005334_abnormal_fat_pad0.65646625
148MP0010771_integument_phenotype0.63703628
149MP0002928_abnormal_bile_duct0.61936643
150MP0001348_abnormal_lacrimal_gland0.61809635
151MP0000358_abnormal_cell_content/0.61768264
152MP0004270_analgesia0.60935874
153MP0006035_abnormal_mitochondrial_morpho0.60891790
154MP0002572_abnormal_emotion/affect_behav0.60590522
155MP0005266_abnormal_metabolism0.60371807
156MP0001765_abnormal_ion_homeostasis0.60244177
157MP0001501_abnormal_sleep_pattern0.59771141
158MP0004885_abnormal_endolymph0.59525145
159MP0004130_abnormal_muscle_cell0.57960672
160MP0008873_increased_physiological_sensi0.57075536
161MP0002970_abnormal_white_adipose0.55511154
162MP0002269_muscular_atrophy0.55466760
163MP0002733_abnormal_thermal_nociception0.55446470
164MP0003075_altered_response_to0.53675416
165MP0004858_abnormal_nervous_system0.53364288
166MP0003633_abnormal_nervous_system0.53015274
167MP0005376_homeostasis/metabolism_phenot0.52706853
168MP0002069_abnormal_eating/drinking_beha0.52684288
169MP0004264_abnormal_extraembryonic_tissu0.52189348
170MP0009763_increased_sensitivity_to0.50708446
171MP0005647_abnormal_sex_gland0.50438698
172MP0003656_abnormal_erythrocyte_physiolo0.50351774
173MP0010368_abnormal_lymphatic_system0.50096061
174MP0001756_abnormal_urination0.49750345
175MP0002234_abnormal_pharynx_morphology0.49732851
176MP0005379_endocrine/exocrine_gland_phen0.49283370
177MP0000003_abnormal_adipose_tissue0.48017116
178MP0005166_decreased_susceptibility_to0.46248727
179MP0002971_abnormal_brown_adipose0.43055256
180MP0009765_abnormal_xenobiotic_induced0.38838267

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.22748461
2Deep venous thrombosis (HP:0002625)5.97269977
3Intrahepatic cholestasis (HP:0001406)5.43174138
4Hypobetalipoproteinemia (HP:0003563)5.19253683
5Xanthomatosis (HP:0000991)4.90929949
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.88066867
7Ketosis (HP:0001946)4.21139072
8Ketoacidosis (HP:0001993)4.13737548
9Prolonged partial thromboplastin time (HP:0003645)4.05407785
10Hyperlipoproteinemia (HP:0010980)3.92007249
11Hypoglycemic seizures (HP:0002173)3.83267253
12Hypoglycemic coma (HP:0001325)3.80832498
13Hypolipoproteinemia (HP:0010981)3.51214763
14Abnormality of the common coagulation pathway (HP:0010990)3.44085028
15Hyperammonemia (HP:0001987)3.39760910
16Complement deficiency (HP:0004431)3.33628484
17Increased mean platelet volume (HP:0011877)3.33396131
18Menorrhagia (HP:0000132)3.28277288
19Hyperacusis (HP:0010780)3.26677344
20Prolonged bleeding time (HP:0003010)3.24403416
21Epidermoid cyst (HP:0200040)3.19466057
22Distal lower limb amyotrophy (HP:0008944)3.18541300
23Abnormal platelet volume (HP:0011876)3.15285994
24Abnormality of the intrinsic pathway (HP:0010989)3.10785080
25Abnormality of the lower motor neuron (HP:0002366)3.08135668
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.03284850
27Hyperinsulinemic hypoglycemia (HP:0000825)3.03215635
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.02028864
29Spastic diplegia (HP:0001264)2.97918356
30Hyperglycinemia (HP:0002154)2.93220056
31Late onset (HP:0003584)2.90245353
32Delayed CNS myelination (HP:0002188)2.86833765
33Purpura (HP:0000979)2.82954732
34Gout (HP:0001997)2.82490093
35Abnormality of endocrine pancreas physiology (HP:0012093)2.79946516
36Abnormality of the pancreatic islet cells (HP:0006476)2.79946516
37Fat malabsorption (HP:0002630)2.78091798
38Flat acetabular roof (HP:0003180)2.76779320
39Hyperthyroidism (HP:0000836)2.74733801
40Hypoalphalipoproteinemia (HP:0003233)2.70852226
41Ankyloglossia (HP:0010296)2.69394566
42Neonatal onset (HP:0003623)2.65827400
43Progressive muscle weakness (HP:0003323)2.63954770
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.61821297
45Global brain atrophy (HP:0002283)2.58807342
46Abnormality of the Achilles tendon (HP:0005109)2.56614295
47Abnormality of glycine metabolism (HP:0010895)2.56093977
48Abnormality of serine family amino acid metabolism (HP:0010894)2.56093977
49Symptomatic seizures (HP:0011145)2.55939491
50Abnormality of methionine metabolism (HP:0010901)2.53852549
51Abnormal gallbladder physiology (HP:0012438)2.53498741
52Cholecystitis (HP:0001082)2.53498741
53Hyperbilirubinemia (HP:0002904)2.53486178
54Conjugated hyperbilirubinemia (HP:0002908)2.53461378
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52224004
56Joint hemorrhage (HP:0005261)2.48104237
57Cerebral inclusion bodies (HP:0100314)2.47632626
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43014672
59Truncus arteriosus (HP:0001660)2.40716814
60Broad face (HP:0000283)2.40565862
61Insomnia (HP:0100785)2.39985135
62Distal lower limb muscle weakness (HP:0009053)2.37289726
63Visual hallucinations (HP:0002367)2.36871758
64Hyperparathyroidism (HP:0000843)2.36591071
65Abnormality of complement system (HP:0005339)2.34743408
66Acanthocytosis (HP:0001927)2.34620316
67Hyperglycinuria (HP:0003108)2.32886735
68Back pain (HP:0003418)2.32622778
69Ulnar bowing (HP:0003031)2.32141689
70Asymmetry of the thorax (HP:0001555)2.31927263
71Skin nodule (HP:0200036)2.30234633
72Abnormal platelet function (HP:0011869)2.29300984
73Impaired platelet aggregation (HP:0003540)2.29300984
74Hepatocellular carcinoma (HP:0001402)2.28293387
75Hypercholesterolemia (HP:0003124)2.27656458
76Hyperglycemia (HP:0003074)2.27268324
77Petechiae (HP:0000967)2.26144165
78Epistaxis (HP:0000421)2.25616045
79Status epilepticus (HP:0002133)2.24973305
80Protrusio acetabuli (HP:0003179)2.23935092
81Abnormality of the tricuspid valve (HP:0001702)2.23436539
82Spontaneous abortion (HP:0005268)2.23399223
83Centrally nucleated skeletal muscle fibers (HP:0003687)2.21060188
84Dysmetric saccades (HP:0000641)2.19619881
85Insidious onset (HP:0003587)2.19070065
86Termporal pattern (HP:0011008)2.19070065
87Abnormality of the fingertips (HP:0001211)2.15479788
88Abnormal gallbladder morphology (HP:0012437)2.15161914
89Abnormality of the thoracic spine (HP:0100711)2.12653570
90Irritability (HP:0000737)2.09232286
91Mitral stenosis (HP:0001718)2.09074043
92Sensorimotor neuropathy (HP:0007141)2.08406999
93Death in childhood (HP:0003819)2.08141590
94Cholelithiasis (HP:0001081)2.07440267
95Abnormality of oral frenula (HP:0000190)2.06109897
96Abnormal social behavior (HP:0012433)2.06075815
97Impaired social interactions (HP:0000735)2.06075815
98Septate vagina (HP:0001153)2.05933807
99Exercise-induced myalgia (HP:0003738)2.05026970
100Achilles tendon contracture (HP:0001771)2.04844719
101Fragile skin (HP:0001030)2.04163211
102Fatigue (HP:0012378)2.03774630
103Abnormality of purine metabolism (HP:0004352)2.03109662
104Thrombocytosis (HP:0001894)2.00922413
105Focal motor seizures (HP:0011153)2.00657398
106Abnormality of nucleobase metabolism (HP:0010932)1.99646521
107Metabolic acidosis (HP:0001942)1.98288773
108Lower limb amyotrophy (HP:0007210)1.97194056
109Vertebral compression fractures (HP:0002953)1.97010522
110Abnormality of fatty-acid metabolism (HP:0004359)1.96504104
111Abnormality of serum amino acid levels (HP:0003112)1.96471118
112Testicular neoplasm (HP:0010788)1.94673511
113Trismus (HP:0000211)1.93358931
114Abnormality of pyrimidine metabolism (HP:0004353)1.92720241
115Spinal cord lesions (HP:0100561)1.92447341
116Syringomyelia (HP:0003396)1.92447341
117Spinal cord compression (HP:0002176)1.92405425
118Progressive external ophthalmoplegia (HP:0000590)1.91759433
119Short nail (HP:0001799)1.91271537
120Elbow flexion contracture (HP:0002987)1.91160035
121Bowel incontinence (HP:0002607)1.91070196
122Amyotrophic lateral sclerosis (HP:0007354)1.90312686
123Hypercortisolism (HP:0001578)1.89430109
124Acute hepatic failure (HP:0006554)1.88924449
125Tetraplegia (HP:0002445)1.87430720
126Hypochromic microcytic anemia (HP:0004840)1.87335791
127Abnormality of reticulocytes (HP:0004312)1.86434663
128Impaired vibration sensation in the lower limbs (HP:0002166)1.86128134
129Premature rupture of membranes (HP:0001788)1.86052061
130Myocardial infarction (HP:0001658)1.85695946
131Cerebral aneurysm (HP:0004944)1.85495967
132Abnormality of the distal phalanges of the toes (HP:0010182)1.85466798
133Myokymia (HP:0002411)1.85225689
134Abnormal large intestine physiology (HP:0012700)1.84456247
135Self-mutilation (HP:0000742)1.84390506
136Seborrheic dermatitis (HP:0001051)1.83967774
137Ragged-red muscle fibers (HP:0003200)1.82716421
138Deep palmar crease (HP:0006191)1.82133154
139Cellulitis (HP:0100658)1.81755819
140Reticulocytosis (HP:0001923)1.81680302
141Hemorrhage of the eye (HP:0011885)1.80510503
142Poor eye contact (HP:0000817)1.78541471
143Abnormality of the gallbladder (HP:0005264)1.77972136
144Hemiplegia (HP:0002301)1.76807046
145Venous abnormality (HP:0002624)1.76430995
146Brushfield spots (HP:0001088)1.76323571
147Missing ribs (HP:0000921)1.76292114
148Neurofibrillary tangles (HP:0002185)1.75776722
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74937673
150Pseudobulbar signs (HP:0002200)1.74915702
151Obstructive sleep apnea (HP:0002870)1.74880577
152Patellar dislocation (HP:0002999)1.74475146
153Abnormality of the calcaneus (HP:0008364)1.74062895
154Stroke (HP:0001297)1.73677900
155Upper limb amyotrophy (HP:0009129)1.73646748
156Distal upper limb amyotrophy (HP:0007149)1.73646748
157Deviation of the thumb (HP:0009603)1.73413443
158Abnormal cartilage morphology (HP:0002763)1.73396934
159Disproportionate tall stature (HP:0001519)1.73341091
16011 pairs of ribs (HP:0000878)1.72560158
161Gingival bleeding (HP:0000225)1.72512772
162Polycythemia (HP:0001901)1.71074140
163Macroorchidism (HP:0000053)1.70578266
164Increased connective tissue (HP:0009025)1.70057910
165Atelectasis (HP:0100750)1.69803615
166Pancreatic islet-cell hyperplasia (HP:0004510)1.69494505
167Generalized hyperpigmentation (HP:0007440)1.69426434
168Heterotopia (HP:0002282)1.69268229
169Turricephaly (HP:0000262)1.68223965
170Pointed chin (HP:0000307)1.67387591
171Growth hormone excess (HP:0000845)1.66162566
172Acute lymphatic leukemia (HP:0006721)1.66000536
173Abnormal ossification of hand bones (HP:0005921)1.65999452
174Abnormality of skeletal muscle fiber size (HP:0012084)1.64842949
175Thoracic kyphosis (HP:0002942)1.64585679
176Abnormality of carpal bone ossification (HP:0006257)1.64543128
177Confusion (HP:0001289)1.63517684
178Poikilocytosis (HP:0004447)1.63367977
179Steatorrhea (HP:0002570)1.62972887
180Broad palm (HP:0001169)1.62459095
181Craniofacial dystonia (HP:0012179)1.61466161
182Unilateral renal agenesis (HP:0000122)1.61309300
183Proximal placement of thumb (HP:0009623)1.61005354
184Esophageal varix (HP:0002040)1.60144512
185Increased variability in muscle fiber diameter (HP:0003557)1.56902271
186Mitral regurgitation (HP:0001653)1.56403711
187Germ cell neoplasia (HP:0100728)1.56031342
188Broad distal phalanx of finger (HP:0009836)1.55956614
189Long palpebral fissure (HP:0000637)1.55332771
190Polygenic inheritance (HP:0010982)1.55183670
191Abnormality of the gastric mucosa (HP:0004295)1.54825771
192Difficulty climbing stairs (HP:0003551)1.52577018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.96958416
2PKN23.57306370
3SMG13.54232628
4PRPF4B2.88030259
5MAP3K102.76577878
6EEF2K2.59506160
7IRAK32.58924283
8FGFR42.56632756
9BCKDK2.53324765
10SCYL22.49849832
11DAPK22.41866889
12NME22.38357892
13NTRK32.35472267
14KSR12.34137795
15NTRK12.30503167
16EPHA42.26361871
17SIK12.23417264
18MAP3K92.16533515
19ERN12.12932769
20MAP2K42.01667497
21EPHA22.01162738
22GRK62.00205918
23MST1R1.96659592
24KSR21.93936654
25MAP3K21.72108976
26INSRR1.71977932
27TTN1.61265096
28RPS6KB21.58657589
29MINK11.57027318
30RET1.53568734
31MAP3K41.53163631
32EIF2AK11.52174333
33SIK21.51396225
34PTK61.49828121
35ALK1.45904209
36TYRO31.36492568
37PASK1.35003149
38DAPK11.30394490
39CAMKK11.24297096
40HIPK21.23921203
41PBK1.11591490
42BRAF1.08487595
43SIK31.06708751
44FLT31.05459256
45MAP4K11.01976948
46PRKD31.01853663
47TAOK10.99769858
48TAOK20.94259808
49PAK60.93962816
50PDGFRA0.90213616
51CDK70.89337769
52PAK30.88845103
53NTRK20.88600919
54ILK0.86697053
55IRAK20.86635027
56MAP3K10.86602224
57TGFBR10.83861861
58MET0.81184375
59MAP3K70.80496158
60ZAP700.78235872
61CDK80.77784146
62RIPK10.77137841
63LRRK20.77004354
64MAP3K80.76434946
65MARK20.75165935
66UHMK10.74331394
67PRKCH0.73132190
68TNK20.71090422
69MAPK110.70907638
70RPS6KL10.70469820
71RPS6KC10.70469820
72JAK20.69469079
73EPHA30.69020865
74FER0.69008065
75CDK50.68011012
76PAK40.67969377
77PTK20.67262323
78PIM20.67000855
79RPS6KA20.66017807
80MAP2K20.64465753
81AKT20.62908299
82PNCK0.62719244
83MAP2K30.61415375
84MAP3K50.61098147
85MAP3K30.59934667
86CDK90.58941255
87NEK20.57560811
88PRKCG0.57209562
89PRKG20.56763260
90ICK0.56679844
91ARAF0.55205128
92MAP3K60.54106431
93FES0.54016836
94MAP3K140.53907295
95AURKA0.53657492
96MTOR0.53281444
97CHEK10.53072168
98CHEK20.52624382
99CDK60.49968608
100FGFR20.47757213
101PDK10.47744048
102CDK40.47439312
103MAP3K130.46734691
104BRD40.46628600
105MARK10.46551471
106MAP3K110.45762687
107RPS6KB10.45601521
108RIPK40.45086563
109JAK10.44396982
110MAP2K10.44230431
111CSNK1E0.44094922
112LATS20.43528510
113MAPK150.42169937
114PAK20.42094340
115STK40.42059596
116TAOK30.41363963
117MAPKAPK30.41037184
118CSNK1G20.41023033
119RPS6KA60.40584145
120MELK0.40434755
121ERBB40.40271026
122RAF10.38886345
123TESK10.38418402
124MAPK100.38195715
125TBK10.38006158
126MAP2K60.37328382
127PRKCZ0.37257239
128STK110.36398209
129MAPK120.36003026
130BTK0.34905053
131CDK20.34691457
132CDC42BPA0.34094245
133FGFR30.33327324
134NEK10.32756131
135PRKACG0.32498217
136CDK120.32314341
137RPS6KA30.32183026
138RPS6KA10.31523701
139ERBB20.30823744
140PAK10.30164640
141WNK10.30039121
142SGK30.29544073
143EPHB10.29486733
144DAPK30.28912368
145PDPK10.28679497
146BMX0.28520298
147DMPK0.28427926
148ATR0.27734439
149CAMK1G0.27648356
150LMTK20.26648950
151STK380.25687064

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.40078170
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.20723527
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.79096092
4Arginine biosynthesis_Homo sapiens_hsa002203.16595564
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05536403
6Chronic myeloid leukemia_Homo sapiens_hsa052202.68479472
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51574150
8Tryptophan metabolism_Homo sapiens_hsa003802.33110812
9Acute myeloid leukemia_Homo sapiens_hsa052212.30196526
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21415017
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17228898
12Butanoate metabolism_Homo sapiens_hsa006502.14100719
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.13964469
14Pancreatic cancer_Homo sapiens_hsa052122.13446105
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.13361185
16Fatty acid degradation_Homo sapiens_hsa000712.07777642
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04800043
18Complement and coagulation cascades_Homo sapiens_hsa046101.96442619
19Bile secretion_Homo sapiens_hsa049761.89488781
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88142400
21Caffeine metabolism_Homo sapiens_hsa002321.84930881
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80842765
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76895411
24Sulfur metabolism_Homo sapiens_hsa009201.72706835
25VEGF signaling pathway_Homo sapiens_hsa043701.72018360
26Endometrial cancer_Homo sapiens_hsa052131.68806199
27Selenocompound metabolism_Homo sapiens_hsa004501.68050382
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.60991719
29Other glycan degradation_Homo sapiens_hsa005111.60197334
30Platelet activation_Homo sapiens_hsa046111.56423171
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.55564716
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51339821
33Small cell lung cancer_Homo sapiens_hsa052221.49112391
34Biosynthesis of amino acids_Homo sapiens_hsa012301.45733643
35Notch signaling pathway_Homo sapiens_hsa043301.44531985
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40429118
37Peroxisome_Homo sapiens_hsa041461.38505259
38B cell receptor signaling pathway_Homo sapiens_hsa046621.36630487
39DNA replication_Homo sapiens_hsa030301.36382410
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35814027
41Propanoate metabolism_Homo sapiens_hsa006401.33366467
42ErbB signaling pathway_Homo sapiens_hsa040121.32553969
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32088277
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.31543851
45Chemical carcinogenesis_Homo sapiens_hsa052041.31464947
46Renal cell carcinoma_Homo sapiens_hsa052111.28612312
47Fatty acid metabolism_Homo sapiens_hsa012121.27274305
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27236787
49PPAR signaling pathway_Homo sapiens_hsa033201.26889425
50Pyruvate metabolism_Homo sapiens_hsa006201.23322899
51Folate biosynthesis_Homo sapiens_hsa007901.21752561
52beta-Alanine metabolism_Homo sapiens_hsa004101.17326422
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.16636957
54Carbon metabolism_Homo sapiens_hsa012001.16265865
55Histidine metabolism_Homo sapiens_hsa003401.15602887
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15514418
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13669299
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13134098
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12496853
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11443257
61Inositol phosphate metabolism_Homo sapiens_hsa005621.10867673
62mRNA surveillance pathway_Homo sapiens_hsa030151.10414084
63Fat digestion and absorption_Homo sapiens_hsa049751.10403021
64Fructose and mannose metabolism_Homo sapiens_hsa000511.09750461
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09638310
66Phenylalanine metabolism_Homo sapiens_hsa003601.09628103
67Prostate cancer_Homo sapiens_hsa052151.08656317
68Ribosome_Homo sapiens_hsa030101.07601469
69Viral carcinogenesis_Homo sapiens_hsa052031.07407452
70Colorectal cancer_Homo sapiens_hsa052101.05127165
71Starch and sucrose metabolism_Homo sapiens_hsa005001.01053273
72Focal adhesion_Homo sapiens_hsa045100.99719785
73Sulfur relay system_Homo sapiens_hsa041220.92341481
74Cell cycle_Homo sapiens_hsa041100.91999955
75Choline metabolism in cancer_Homo sapiens_hsa052310.91426461
76Long-term potentiation_Homo sapiens_hsa047200.91423932
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90595682
78Prolactin signaling pathway_Homo sapiens_hsa049170.89942149
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88810303
80Tyrosine metabolism_Homo sapiens_hsa003500.88289768
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86691164
82Proteoglycans in cancer_Homo sapiens_hsa052050.83627167
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.83442072
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.81416593
85ECM-receptor interaction_Homo sapiens_hsa045120.81303451
86Base excision repair_Homo sapiens_hsa034100.80506180
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80108172
88Lysine degradation_Homo sapiens_hsa003100.80025558
89Adherens junction_Homo sapiens_hsa045200.79332411
90Prion diseases_Homo sapiens_hsa050200.79285825
91Hepatitis B_Homo sapiens_hsa051610.78336541
92Endocytosis_Homo sapiens_hsa041440.77324492
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76298031
94Glucagon signaling pathway_Homo sapiens_hsa049220.76076147
95ABC transporters_Homo sapiens_hsa020100.75826506
96Amoebiasis_Homo sapiens_hsa051460.74820791
97Insulin secretion_Homo sapiens_hsa049110.73193869
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72857771
99MicroRNAs in cancer_Homo sapiens_hsa052060.72816587
100Apoptosis_Homo sapiens_hsa042100.71819606
101Alcoholism_Homo sapiens_hsa050340.71463096
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.71133360
103Hepatitis C_Homo sapiens_hsa051600.70793125
104HTLV-I infection_Homo sapiens_hsa051660.70318243
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70049851
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.68986217
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68426774
108N-Glycan biosynthesis_Homo sapiens_hsa005100.68162779
109HIF-1 signaling pathway_Homo sapiens_hsa040660.65074521
110Spliceosome_Homo sapiens_hsa030400.63631723
111Amphetamine addiction_Homo sapiens_hsa050310.63039790
112Shigellosis_Homo sapiens_hsa051310.61270823
113GABAergic synapse_Homo sapiens_hsa047270.61191270
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60459981
115Retinol metabolism_Homo sapiens_hsa008300.59717369
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59483311
117Arginine and proline metabolism_Homo sapiens_hsa003300.59323027
118Type II diabetes mellitus_Homo sapiens_hsa049300.59216944
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58991234
120Insulin resistance_Homo sapiens_hsa049310.57207046
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56614970
122One carbon pool by folate_Homo sapiens_hsa006700.56232169
123Staphylococcus aureus infection_Homo sapiens_hsa051500.56191033
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55304613
125Gap junction_Homo sapiens_hsa045400.54957897
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54711657
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53360902
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53144601
129Dopaminergic synapse_Homo sapiens_hsa047280.51981291
130Melanoma_Homo sapiens_hsa052180.51765958
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.51463351
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51459166
133Pathways in cancer_Homo sapiens_hsa052000.50233887
134RNA transport_Homo sapiens_hsa030130.50152943
135FoxO signaling pathway_Homo sapiens_hsa040680.49410381
136Glycerolipid metabolism_Homo sapiens_hsa005610.48618763
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48056615
138Fatty acid biosynthesis_Homo sapiens_hsa000610.46391934
139Estrogen signaling pathway_Homo sapiens_hsa049150.43791992
140Thyroid hormone synthesis_Homo sapiens_hsa049180.42726090
141Cocaine addiction_Homo sapiens_hsa050300.41913653
142Synaptic vesicle cycle_Homo sapiens_hsa047210.41799206
143Non-small cell lung cancer_Homo sapiens_hsa052230.41067684
144Insulin signaling pathway_Homo sapiens_hsa049100.40693950
145Circadian entrainment_Homo sapiens_hsa047130.39315950
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35915500
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35820633
148Bladder cancer_Homo sapiens_hsa052190.35011986
149Pentose phosphate pathway_Homo sapiens_hsa000300.33538449
150Gastric acid secretion_Homo sapiens_hsa049710.32475572
151Galactose metabolism_Homo sapiens_hsa000520.32317215
152Glioma_Homo sapiens_hsa052140.30345367
153AMPK signaling pathway_Homo sapiens_hsa041520.29888807
154mTOR signaling pathway_Homo sapiens_hsa041500.29417616
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.27651535
156Glutamatergic synapse_Homo sapiens_hsa047240.25947645
157Salivary secretion_Homo sapiens_hsa049700.25044415
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23139045
159Taste transduction_Homo sapiens_hsa047420.21650369
160Thyroid cancer_Homo sapiens_hsa052160.21262016
161Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20506329
162GnRH signaling pathway_Homo sapiens_hsa049120.20458945
163Olfactory transduction_Homo sapiens_hsa047400.20454851
164Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19435448
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18040204
166Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17346450

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