WSB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.68441812
2presynaptic membrane assembly (GO:0097105)5.44600776
3nucleobase catabolic process (GO:0046113)5.36921115
4presynaptic membrane organization (GO:0097090)4.82148957
5positive regulation of mitochondrial fission (GO:0090141)4.47491145
6postsynaptic membrane organization (GO:0001941)4.42495715
7calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.34511831
8mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.32486290
9positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.32486290
10neuron cell-cell adhesion (GO:0007158)4.25467049
11nonmotile primary cilium assembly (GO:0035058)4.20603301
12retinal ganglion cell axon guidance (GO:0031290)4.06283646
13replication fork processing (GO:0031297)3.93397490
14DNA strand renaturation (GO:0000733)3.88552028
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87071914
16synapse assembly (GO:0007416)3.81480884
17dendritic spine morphogenesis (GO:0060997)3.79811629
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76355275
19epithelial cilium movement (GO:0003351)3.75944902
20neurotransmitter-gated ion channel clustering (GO:0072578)3.73953389
21olfactory bulb development (GO:0021772)3.73257700
22axonal fasciculation (GO:0007413)3.72994469
23intraciliary transport (GO:0042073)3.70993236
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.69732998
25limb bud formation (GO:0060174)3.64051421
26neural tube formation (GO:0001841)3.63604639
27kinetochore assembly (GO:0051382)3.60305908
28auditory behavior (GO:0031223)3.59771079
29mitotic metaphase plate congression (GO:0007080)3.56146725
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53837819
31mRNA splice site selection (GO:0006376)3.53571784
32vocalization behavior (GO:0071625)3.53033865
33purine nucleobase biosynthetic process (GO:0009113)3.52941069
34behavioral response to nicotine (GO:0035095)3.52591359
35protein localization to synapse (GO:0035418)3.48879156
36kinetochore organization (GO:0051383)3.48186970
37protein localization to cilium (GO:0061512)3.43905490
38gamma-aminobutyric acid transport (GO:0015812)3.42763483
39central nervous system projection neuron axonogenesis (GO:0021952)3.40280709
40negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39981837
41cilium morphogenesis (GO:0060271)3.38731248
42regulation of spindle organization (GO:0090224)3.37543768
43establishment of mitochondrion localization (GO:0051654)3.36667424
44neuron recognition (GO:0008038)3.30697928
45negative regulation of RNA splicing (GO:0033119)3.30372954
46poly(A)+ mRNA export from nucleus (GO:0016973)3.29566667
47response to pheromone (GO:0019236)3.26569570
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26519606
49transmission of nerve impulse (GO:0019226)3.26024861
50negative regulation of chromosome segregation (GO:0051985)3.23441427
51glycosphingolipid biosynthetic process (GO:0006688)3.22040882
52negative regulation of mRNA processing (GO:0050686)3.21038278
53spindle checkpoint (GO:0031577)3.20381427
54regulation of cilium movement (GO:0003352)3.17185996
55mechanosensory behavior (GO:0007638)3.14890457
56cerebral cortex radially oriented cell migration (GO:0021799)3.14673146
57viral mRNA export from host cell nucleus (GO:0046784)3.14561211
58mitotic spindle assembly checkpoint (GO:0007094)3.14538040
59mitotic spindle checkpoint (GO:0071174)3.13631263
60protein polyglutamylation (GO:0018095)3.12912982
61cilium assembly (GO:0042384)3.12422941
62cilium organization (GO:0044782)3.11042737
63central nervous system neuron axonogenesis (GO:0021955)3.10467856
64spindle assembly checkpoint (GO:0071173)3.10456757
65negative regulation of axon guidance (GO:1902668)3.10116080
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09375139
67mitotic sister chromatid cohesion (GO:0007064)3.07751044
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07613865
69negative regulation of sister chromatid segregation (GO:0033046)3.07613865
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.07613865
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07613865
72somite development (GO:0061053)3.07000063
73regulation of mitochondrial fission (GO:0090140)3.06172547
74protein localization to kinetochore (GO:0034501)3.05103235
75cilium movement (GO:0003341)3.04965959
76negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02375884
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00171185
78metaphase plate congression (GO:0051310)2.99490637
79nucleobase biosynthetic process (GO:0046112)2.99379563
80regulation of collateral sprouting (GO:0048670)2.98859892
81DNA double-strand break processing (GO:0000729)2.98635136
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.98365497
83regulation of RNA export from nucleus (GO:0046831)2.97915695
84lung-associated mesenchyme development (GO:0060484)2.97749939
85regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97604996
86regulation of histone H3-K27 methylation (GO:0061085)2.96167543
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95536746
88positive regulation of synapse assembly (GO:0051965)2.94976722
89regulation of development, heterochronic (GO:0040034)2.94822588
90regulation of double-strand break repair via homologous recombination (GO:0010569)2.91317331
91maturation of 5.8S rRNA (GO:0000460)2.90822731
92DNA integration (GO:0015074)2.89008611
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88500151
94regulation of feeding behavior (GO:0060259)2.87633794
95DNA replication checkpoint (GO:0000076)2.86504682
96regulation of sister chromatid segregation (GO:0033045)2.85209155
97regulation of mitotic sister chromatid separation (GO:0010965)2.85209155
98regulation of mitotic sister chromatid segregation (GO:0033047)2.85209155
99termination of RNA polymerase II transcription (GO:0006369)2.84212221
100DNA topological change (GO:0006265)2.82110573
101regulation of chromosome segregation (GO:0051983)2.80933440
102sequestering of actin monomers (GO:0042989)2.80613333
103response to auditory stimulus (GO:0010996)2.79048863
104neuronal action potential propagation (GO:0019227)2.76227881
105vitamin transmembrane transport (GO:0035461)2.74467937
106synapse organization (GO:0050808)2.73826700
107axoneme assembly (GO:0035082)2.73159793
108positive regulation of amino acid transport (GO:0051957)2.72802837
109negative regulation of oligodendrocyte differentiation (GO:0048715)2.70587464
110regulation of mitotic spindle organization (GO:0060236)2.70143783
111dendrite morphogenesis (GO:0048813)2.68922200
112inner ear receptor stereocilium organization (GO:0060122)2.68841318
113behavioral response to ethanol (GO:0048149)2.68657859
114negative regulation of fibroblast apoptotic process (GO:2000270)2.66337011
115cornea development in camera-type eye (GO:0061303)2.66247797
116regulation of sister chromatid cohesion (GO:0007063)2.65225664
117cerebral cortex cell migration (GO:0021795)2.64663602
118regulation of synapse structural plasticity (GO:0051823)2.64504477
119establishment of protein localization to Golgi (GO:0072600)2.64261937
120ribosome assembly (GO:0042255)2.64175762
121spinal cord development (GO:0021510)2.64120330
122head development (GO:0060322)2.63800009
123facial nerve structural organization (GO:0021612)2.63613743
124short-term memory (GO:0007614)2.63569496
125positive regulation of oligodendrocyte differentiation (GO:0048714)2.63407848
126mitotic sister chromatid segregation (GO:0000070)2.62933732
127adult walking behavior (GO:0007628)2.61355137
128homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.61330077
129forebrain neuron differentiation (GO:0021879)2.60627963
130limb development (GO:0060173)2.60412788
131appendage development (GO:0048736)2.60412788
132mRNA splicing, via spliceosome (GO:0000398)2.60333978
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.60333978
134glial cell proliferation (GO:0014009)2.59319469
135heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.59160768
136regulation of mRNA splicing, via spliceosome (GO:0048024)2.58900559
137sister chromatid segregation (GO:0000819)2.58156289
138histone H2A acetylation (GO:0043968)2.57918789
139protein targeting to Golgi (GO:0000042)2.57609415
140RNA splicing, via transesterification reactions (GO:0000375)2.57413461
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.57202409
142positive regulation of chromosome segregation (GO:0051984)2.57037659
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56619608
144face development (GO:0060324)2.56382397
145neuron fate determination (GO:0048664)2.55764862
146termination of RNA polymerase I transcription (GO:0006363)2.55740673
147hippocampus development (GO:0021766)2.54568360
148DNA-templated transcription, termination (GO:0006353)2.53877476
149meiotic chromosome segregation (GO:0045132)2.53855564
150regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53730604
151regulation of synaptic transmission, glutamatergic (GO:0051966)2.53094040
152smoothened signaling pathway (GO:0007224)2.52784829
153protein localization to chromosome, centromeric region (GO:0071459)2.52082118
154microtubule depolymerization (GO:0007019)2.51943782
155histone H4-K8 acetylation (GO:0043982)2.51893286
156histone H4-K5 acetylation (GO:0043981)2.51893286
157platelet dense granule organization (GO:0060155)2.51608783
158hematopoietic stem cell proliferation (GO:0071425)2.50849739
159transcription elongation from RNA polymerase I promoter (GO:0006362)2.50587502
160regulation of oligodendrocyte differentiation (GO:0048713)2.50371221
161neuromuscular synaptic transmission (GO:0007274)2.49612038
162establishment of melanosome localization (GO:0032401)2.48256334
163cellular component assembly involved in morphogenesis (GO:0010927)2.47857345
164trophoblast giant cell differentiation (GO:0060707)2.47224375
165ribosome biogenesis (GO:0042254)2.47133402
166melanosome transport (GO:0032402)2.46381125
167negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46118173
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45253870
169regulation of timing of cell differentiation (GO:0048505)2.45071913
170neuron migration (GO:0001764)2.44307144
171attachment of spindle microtubules to kinetochore (GO:0008608)2.44129338
172hindbrain development (GO:0030902)2.43684074
173positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43579456
174cell migration in hindbrain (GO:0021535)2.42935124
175protein localization to Golgi apparatus (GO:0034067)2.42375253
176mRNA export from nucleus (GO:0006406)2.42030972
177establishment of chromosome localization (GO:0051303)2.41475966
178mitotic recombination (GO:0006312)2.39986265
179negative regulation of mitosis (GO:0045839)2.37270738
180regulation of fibroblast apoptotic process (GO:2000269)2.36190595
181RNA export from nucleus (GO:0006405)2.36046869
182DNA replication initiation (GO:0006270)2.35219165
183spliceosomal snRNP assembly (GO:0000387)2.34295468
184telomere maintenance via semi-conservative replication (GO:0032201)2.32399124
185telomere maintenance via recombination (GO:0000722)2.32034920
186membrane invagination (GO:0010324)2.30698063
187negative regulation of mRNA metabolic process (GO:1903312)2.28880426
188negative regulation by host of viral transcription (GO:0043922)2.28762109
189dosage compensation (GO:0007549)2.28418426
190chromosome segregation (GO:0007059)2.28399617
191positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.27108605
192positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.27108605
193positive regulation of mitotic sister chromatid separation (GO:1901970)2.27108605
194protein localization to chromosome (GO:0034502)2.26190692
195regulation of DNA damage checkpoint (GO:2000001)2.25937652
196DNA replication-independent nucleosome assembly (GO:0006336)2.25313286
197DNA replication-independent nucleosome organization (GO:0034724)2.25313286
198DNA strand elongation involved in DNA replication (GO:0006271)2.24388707
199mitotic nuclear envelope disassembly (GO:0007077)2.22857222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.39570309
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.23496881
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.07615525
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.96939328
5EZH2_22144423_ChIP-Seq_EOC_Human3.88511000
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65209060
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.48734059
8GBX2_23144817_ChIP-Seq_PC3_Human3.48453316
9IGF1R_20145208_ChIP-Seq_DFB_Human3.43983011
10* ZNF274_21170338_ChIP-Seq_K562_Hela3.13176266
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95387863
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93994897
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.92208973
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.90960303
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69295402
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67217849
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.63549414
18* TAF15_26573619_Chip-Seq_HEK293_Human2.52534786
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.48080579
20FUS_26573619_Chip-Seq_HEK293_Human2.41249956
21* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40218633
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34547813
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27581996
24P300_19829295_ChIP-Seq_ESCs_Human2.15855618
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12883384
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07453431
27VDR_22108803_ChIP-Seq_LS180_Human2.05208272
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02258729
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00299220
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98478984
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96990881
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95793586
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.95053800
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.94998828
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.90754989
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.88665157
37* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.87923629
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.87777326
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86501475
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81913147
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81182733
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81104420
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80780630
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.80335695
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80205598
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78883416
47SMAD4_21799915_ChIP-Seq_A2780_Human1.78452631
48AR_21909140_ChIP-Seq_LNCAP_Human1.77429877
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76461648
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75134361
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74730863
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74680695
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74548236
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73566552
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73226346
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72796286
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71062950
58TTF2_22483619_ChIP-Seq_HELA_Human1.64088802
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62692854
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59374330
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58068501
62REST_21632747_ChIP-Seq_MESCs_Mouse1.58033545
63IRF1_19129219_ChIP-ChIP_H3396_Human1.55261971
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54423919
65ER_23166858_ChIP-Seq_MCF-7_Human1.54276900
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54051310
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.52283683
68* STAT3_23295773_ChIP-Seq_U87_Human1.51103630
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50305704
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49360308
71CBP_20019798_ChIP-Seq_JUKART_Human1.49285836
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49285836
73* AR_25329375_ChIP-Seq_VCAP_Human1.48324065
74* SMAD3_21741376_ChIP-Seq_EPCs_Human1.48010610
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46909295
76EWS_26573619_Chip-Seq_HEK293_Human1.46752737
77* XRN2_22483619_ChIP-Seq_HELA_Human1.46262152
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46098744
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45197301
80ELK1_19687146_ChIP-ChIP_HELA_Human1.40144421
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39262604
82* VDR_23849224_ChIP-Seq_CD4+_Human1.38564296
83* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38088522
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36735745
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36180248
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36180248
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.36133843
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35733302
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35412453
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34552687
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34448325
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.33721954
93AR_21572438_ChIP-Seq_LNCaP_Human1.33154429
94* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32695725
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32317043
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31608799
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31416986
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.31404724
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.31100588
100TCF4_23295773_ChIP-Seq_U87_Human1.30204245
101CIITA_25753668_ChIP-Seq_RAJI_Human1.29761484
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.29279085
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28925832
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28228394
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26598742
106TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26282493
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26144814
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24829765
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23417405
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22503348
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22242136
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22110667
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.21258254
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20908612
115BCAT_22108803_ChIP-Seq_LS180_Human1.19919583
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19667386
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.19176027
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.19175870
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18456462
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17844599
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16938087
122MYC_22102868_ChIP-Seq_BL_Human1.16076743
123GABP_19822575_ChIP-Seq_HepG2_Human1.15569234
124JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15474019
125ETS1_20019798_ChIP-Seq_JURKAT_Human1.15433018
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15383306
127* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15233213
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14587835
129TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14551078
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12468130
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11454389
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10370864
133* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10275697
134* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09449542
135TP53_22573176_ChIP-Seq_HFKS_Human1.08705306
136EZH2_27294783_Chip-Seq_NPCs_Mouse1.08046550
137TCF4_22108803_ChIP-Seq_LS180_Human1.07985580
138P53_22387025_ChIP-Seq_ESCs_Mouse1.06982825
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06821927
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06624535
141* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06435466
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06214366
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06197885
144* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05492568
145DCP1A_22483619_ChIP-Seq_HELA_Human1.05359640
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04642132
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03688737
148SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03669573
149KDM5A_27292631_Chip-Seq_BREAST_Human1.02392877
150HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02061410
151SOX2_19829295_ChIP-Seq_ESCs_Human1.01514658
152NANOG_19829295_ChIP-Seq_ESCs_Human1.01514658
153SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01049342
154NANOG_16153702_ChIP-ChIP_HESCs_Human1.00296600
155* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00024182
156SOX2_16153702_ChIP-ChIP_HESCs_Human0.99981391
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99840929
158TP53_18474530_ChIP-ChIP_U2OS_Human0.98791349
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.98339368
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97169601
161RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96915623
162NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96627885
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96528766
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96159778
165* JUN_21703547_ChIP-Seq_K562_Human0.95966994
166KDM2B_26808549_Chip-Seq_REH_Human0.95470072
167EST1_17652178_ChIP-ChIP_JURKAT_Human0.95223559
168WT1_19549856_ChIP-ChIP_CCG9911_Human0.94771274
169EZH2_27294783_Chip-Seq_ESCs_Mouse0.93947293
170* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93893639
171TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93273494
172* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91814479
173SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91202521
174TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90834928
175TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90476852
176KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90412750
177KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90412750
178KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90412750
179CLOCK_20551151_ChIP-Seq_293T_Human0.89468424
180KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88338755
181* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87658944
182GABP_17652178_ChIP-ChIP_JURKAT_Human0.87263961
183ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85993326
184SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84987024
185RNF2_27304074_Chip-Seq_NSC_Mouse0.84980284
186SPI1_23547873_ChIP-Seq_NB4_Human0.84416012
187* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82774560
188ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82725689
189YY1_21170310_ChIP-Seq_MESCs_Mouse0.82000313
190* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81465080
191FOXP3_21729870_ChIP-Seq_TREG_Human0.80336832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.67869438
2MP0008057_abnormal_DNA_replication3.33511700
3MP0003693_abnormal_embryo_hatching3.03685933
4MP0003111_abnormal_nucleus_morphology3.00576663
5MP0001529_abnormal_vocalization2.93135991
6MP0006276_abnormal_autonomic_nervous2.70999834
7MP0008007_abnormal_cellular_replicative2.66003893
8MP0010094_abnormal_chromosome_stability2.62018014
9MP0001984_abnormal_olfaction2.57971541
10MP0002638_abnormal_pupillary_reflex2.35211968
11MP0003077_abnormal_cell_cycle2.34927119
12MP0005499_abnormal_olfactory_system2.34302731
13MP0005394_taste/olfaction_phenotype2.34302731
14MP0009278_abnormal_bone_marrow2.30789563
15MP0004270_analgesia2.15712976
16MP0010030_abnormal_orbit_morphology2.15511118
17MP0008058_abnormal_DNA_repair2.11433112
18MP0003123_paternal_imprinting2.07541457
19MP0002822_catalepsy2.07423560
20MP0008789_abnormal_olfactory_epithelium2.05740149
21MP0004859_abnormal_synaptic_plasticity2.02479810
22MP0003786_premature_aging2.01926646
23MP0004133_heterotaxia2.01516536
24MP0003121_genomic_imprinting1.95338928
25MP0006292_abnormal_olfactory_placode1.92889827
26MP0000569_abnormal_digit_pigmentation1.90070961
27MP0001486_abnormal_startle_reflex1.84449228
28MP0005253_abnormal_eye_physiology1.83668775
29MP0006072_abnormal_retinal_apoptosis1.81542080
30MP0002396_abnormal_hematopoietic_system1.79918509
31MP0003941_abnormal_skin_development1.75294107
32MP0005551_abnormal_eye_electrophysiolog1.73856785
33MP0003635_abnormal_synaptic_transmissio1.72437701
34MP0002653_abnormal_ependyma_morphology1.69523100
35MP0009745_abnormal_behavioral_response1.66541009
36MP0003136_yellow_coat_color1.65666254
37MP0009046_muscle_twitch1.65293931
38MP0004957_abnormal_blastocyst_morpholog1.62803987
39MP0005187_abnormal_penis_morphology1.61576527
40MP0005171_absent_coat_pigmentation1.61151589
41MP0002009_preneoplasia1.59035326
42MP0002063_abnormal_learning/memory/cond1.58747479
43MP0003938_abnormal_ear_development1.57798010
44MP0002572_abnormal_emotion/affect_behav1.56944698
45MP0002272_abnormal_nervous_system1.55494227
46MP0008932_abnormal_embryonic_tissue1.53371492
47MP0002557_abnormal_social/conspecific_i1.51979676
48MP0004808_abnormal_hematopoietic_stem1.50476960
49MP0003122_maternal_imprinting1.49856915
50MP0000350_abnormal_cell_proliferation1.48248828
51MP0000631_abnormal_neuroendocrine_gland1.47663100
52MP0002184_abnormal_innervation1.46831927
53MP0003385_abnormal_body_wall1.45215445
54MP0004142_abnormal_muscle_tone1.41945794
55MP0000955_abnormal_spinal_cord1.41875310
56MP0001968_abnormal_touch/_nociception1.41444103
57MP0003567_abnormal_fetal_cardiomyocyte1.40804191
58MP0002734_abnormal_mechanical_nocicepti1.40775944
59MP0005248_abnormal_Harderian_gland1.39942142
60MP0000647_abnormal_sebaceous_gland1.38703410
61MP0002282_abnormal_trachea_morphology1.38058646
62MP0005397_hematopoietic_system_phenotyp1.37950536
63MP0001545_abnormal_hematopoietic_system1.37950536
64MP0002938_white_spotting1.37653332
65MP0002064_seizures1.35145824
66MP0003755_abnormal_palate_morphology1.33493992
67MP0002735_abnormal_chemical_nociception1.33072059
68MP0008995_early_reproductive_senescence1.32544331
69MP0002882_abnormal_neuron_morphology1.32077912
70MP0003011_delayed_dark_adaptation1.30631357
71MP0005380_embryogenesis_phenotype1.30600948
72MP0001672_abnormal_embryogenesis/_devel1.30600948
73MP0003828_pulmonary_edema1.30232194
74MP0002752_abnormal_somatic_nervous1.30209278
75MP0005645_abnormal_hypothalamus_physiol1.29375056
76MP0002067_abnormal_sensory_capabilities1.29109437
77MP0002928_abnormal_bile_duct1.28408788
78MP0002736_abnormal_nociception_after1.27322157
79MP0009053_abnormal_anal_canal1.25874459
80MP0005386_behavior/neurological_phenoty1.25061753
81MP0004924_abnormal_behavior1.25061753
82MP0010307_abnormal_tumor_latency1.24957766
83MP0002233_abnormal_nose_morphology1.23371855
84MP0000026_abnormal_inner_ear1.21771742
85MP0004885_abnormal_endolymph1.21208566
86MP0000049_abnormal_middle_ear1.20923326
87MP0004811_abnormal_neuron_physiology1.20039776
88MP0003718_maternal_effect1.19758975
89MP0002234_abnormal_pharynx_morphology1.19737796
90MP0002085_abnormal_embryonic_tissue1.17787991
91MP0001293_anophthalmia1.17138415
92MP0001879_abnormal_lymphatic_vessel1.15616301
93MP0003115_abnormal_respiratory_system1.14725898
94MP0002909_abnormal_adrenal_gland1.12313429
95MP0001188_hyperpigmentation1.12210430
96MP0003787_abnormal_imprinting1.12073998
97MP0002088_abnormal_embryonic_growth/wei1.11798899
98MP0001970_abnormal_pain_threshold1.11537034
99MP0001502_abnormal_circadian_rhythm1.11248682
100MP0003195_calcinosis1.09900276
101MP0003221_abnormal_cardiomyocyte_apopto1.09886843
102MP0005508_abnormal_skeleton_morphology1.09782649
103MP0003937_abnormal_limbs/digits/tail_de1.09264213
104MP0002086_abnormal_extraembryonic_tissu1.08891985
105MP0010386_abnormal_urinary_bladder1.07879629
106MP0003943_abnormal_hepatobiliary_system1.07821861
107MP0002152_abnormal_brain_morphology1.07716177
108MP0001986_abnormal_taste_sensitivity1.07357138
109MP0005391_vision/eye_phenotype1.07312309
110MP0000733_abnormal_muscle_development1.07225605
111MP0003984_embryonic_growth_retardation1.07160284
112MP0005195_abnormal_posterior_eye1.07006902
113MP0000428_abnormal_craniofacial_morphol1.06576689
114MP0003935_abnormal_craniofacial_develop1.06126788
115MP0002084_abnormal_developmental_patter1.05949258
116MP0003119_abnormal_digestive_system1.04133460
117MP0004742_abnormal_vestibular_system1.03239952
118MP0001697_abnormal_embryo_size1.02298800
119MP0003315_abnormal_perineum_morphology1.01356223
120MP0001542_abnormal_bone_strength1.01210639
121MP0005423_abnormal_somatic_nervous0.99746627
122MP0000537_abnormal_urethra_morphology0.99603350
123MP0003942_abnormal_urinary_system0.99588889
124MP0005076_abnormal_cell_differentiation0.99091869
125MP0000778_abnormal_nervous_system0.99060007
126MP0002102_abnormal_ear_morphology0.98983976
127MP0008260_abnormal_autophagy0.98589984
128MP0000432_abnormal_head_morphology0.97682589
129MP0000566_synostosis0.97619097
130MP0006054_spinal_hemorrhage0.96996520
131MP0000427_abnormal_hair_cycle0.96820726
132MP0001730_embryonic_growth_arrest0.96275591
133MP0005503_abnormal_tendon_morphology0.96079294
134MP0000490_abnormal_crypts_of0.95328070
135MP0004197_abnormal_fetal_growth/weight/0.95262203
136MP0003890_abnormal_embryonic-extraembry0.93461418
137MP0002116_abnormal_craniofacial_bone0.93329496
138MP0005084_abnormal_gallbladder_morpholo0.92712388
139MP0001485_abnormal_pinna_reflex0.92496632
140MP0005174_abnormal_tail_pigmentation0.91649876
141MP0000767_abnormal_smooth_muscle0.90963918
142MP0009333_abnormal_splenocyte_physiolog0.90304356
143MP0008877_abnormal_DNA_methylation0.90184658
144MP0005646_abnormal_pituitary_gland0.89757306
145MP0001119_abnormal_female_reproductive0.89138294
146MP0000372_irregular_coat_pigmentation0.88890946
147MP0001963_abnormal_hearing_physiology0.88753081
148MP0002092_abnormal_eye_morphology0.88611669
149MP0000015_abnormal_ear_pigmentation0.88248644
150MP0002733_abnormal_thermal_nociception0.87819465
151MP0001299_abnormal_eye_distance/0.87675542
152MP0002751_abnormal_autonomic_nervous0.87486389
153MP0002080_prenatal_lethality0.87384973
154MP0009250_abnormal_appendicular_skeleto0.86692077
155MP0000534_abnormal_ureter_morphology0.86404391
156MP0002932_abnormal_joint_morphology0.86181356
157MP0002249_abnormal_larynx_morphology0.85791143
158MP0005367_renal/urinary_system_phenotyp0.85409285
159MP0000516_abnormal_urinary_system0.85409285
160MP0001286_abnormal_eye_development0.85109676
161MP0002114_abnormal_axial_skeleton0.84318614
162MP0003861_abnormal_nervous_system0.83777713
163MP0010368_abnormal_lymphatic_system0.83420773
164MP0001324_abnormal_eye_pigmentation0.83395713
165MP0001501_abnormal_sleep_pattern0.82769657
166MP0004883_abnormal_blood_vessel0.82063720
167MP0003448_altered_tumor_morphology0.82058209
168MP0000465_gastrointestinal_hemorrhage0.81992230
169MP0002066_abnormal_motor_capabilities/c0.80752586
170MP0002177_abnormal_outer_ear0.80723769
171MP0002210_abnormal_sex_determination0.79771617
172MP0002069_abnormal_eating/drinking_beha0.78823567
173MP0002109_abnormal_limb_morphology0.78567768
174MP0003878_abnormal_ear_physiology0.78308888
175MP0005377_hearing/vestibular/ear_phenot0.78308888

Predicted human phenotypes

RankGene SetZ-score
1Gait imbalance (HP:0002141)4.19822197
2Medial flaring of the eyebrow (HP:0010747)4.19255925
3True hermaphroditism (HP:0010459)4.08274643
4Congenital primary aphakia (HP:0007707)4.00002966
5Pancreatic cysts (HP:0001737)3.86443476
6Pancreatic fibrosis (HP:0100732)3.83470440
7Nephrogenic diabetes insipidus (HP:0009806)3.72571917
8Drooling (HP:0002307)3.49981317
9Abnormality of midbrain morphology (HP:0002418)3.44093055
10Molar tooth sign on MRI (HP:0002419)3.44093055
11Genital tract atresia (HP:0001827)3.39033063
12Polyphagia (HP:0002591)3.31185614
13Vaginal atresia (HP:0000148)3.29581734
14Hyperventilation (HP:0002883)3.29181491
15Patellar aplasia (HP:0006443)3.28159244
16Excessive salivation (HP:0003781)3.21372755
17Nephronophthisis (HP:0000090)3.17862714
18Birth length less than 3rd percentile (HP:0003561)3.14754347
19Aplasia/Hypoplasia of the patella (HP:0006498)3.12525218
20Cortical dysplasia (HP:0002539)2.99004770
21Poor coordination (HP:0002370)2.85802334
22Specific learning disability (HP:0001328)2.82438996
23Abnormality of the renal medulla (HP:0100957)2.80332120
24Lissencephaly (HP:0001339)2.80328796
25Facial hemangioma (HP:0000329)2.80139832
26Intestinal atresia (HP:0011100)2.75316262
27Chronic hepatic failure (HP:0100626)2.73561367
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69867592
29Short 4th metacarpal (HP:0010044)2.69867592
30Breast hypoplasia (HP:0003187)2.68144219
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67929463
32Occipital encephalocele (HP:0002085)2.66095903
33Hemiparesis (HP:0001269)2.64985640
34Postaxial hand polydactyly (HP:0001162)2.64019066
35Abnormality of the labia minora (HP:0012880)2.63370854
36Fibular aplasia (HP:0002990)2.60431811
37Natal tooth (HP:0000695)2.60004630
38Broad foot (HP:0001769)2.59534974
39Rough bone trabeculation (HP:0100670)2.58706867
40Cystic liver disease (HP:0006706)2.54589068
41Capillary hemangiomas (HP:0005306)2.52116201
42Postaxial foot polydactyly (HP:0001830)2.50371491
43Retinal dysplasia (HP:0007973)2.49244679
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.47624591
45Absent speech (HP:0001344)2.47295078
46Pachygyria (HP:0001302)2.47201217
47Broad-based gait (HP:0002136)2.46940522
48Wrist flexion contracture (HP:0001239)2.38848587
49Amyotrophic lateral sclerosis (HP:0007354)2.37957098
50Abnormality of the renal cortex (HP:0011035)2.37299292
51Asymmetry of the thorax (HP:0001555)2.35745166
52Decreased testicular size (HP:0008734)2.33194144
53Tubulointerstitial nephritis (HP:0001970)2.32820922
54Chromsome breakage (HP:0040012)2.32111418
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.31155741
56Anencephaly (HP:0002323)2.30541170
57Narrow forehead (HP:0000341)2.28813027
58Hyperglycinemia (HP:0002154)2.26777294
59Submucous cleft hard palate (HP:0000176)2.25542375
60Febrile seizures (HP:0002373)2.25062589
61Progressive cerebellar ataxia (HP:0002073)2.24332538
62Syringomyelia (HP:0003396)2.24169386
63Spinal cord lesions (HP:0100561)2.24169386
64Limb dystonia (HP:0002451)2.21874986
65Absent radius (HP:0003974)2.21025534
66Atonic seizures (HP:0010819)2.19123834
67Aplasia involving forearm bones (HP:0009822)2.18724477
68Absent forearm bone (HP:0003953)2.18724477
69Type II lissencephaly (HP:0007260)2.18170869
70Bile duct proliferation (HP:0001408)2.17755802
71Abnormal biliary tract physiology (HP:0012439)2.17755802
72Aplasia/Hypoplasia of the lens (HP:0008063)2.16468168
73Entropion (HP:0000621)2.15444494
74Exotropia (HP:0000577)2.15372436
75Sclerocornea (HP:0000647)2.14982043
76Short tibia (HP:0005736)2.14222836
77Renal cortical cysts (HP:0000803)2.13733130
78Bifid uvula (HP:0000193)2.11451442
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11078637
80Abnormality of the ileum (HP:0001549)2.09872162
81Impulsivity (HP:0100710)2.09207298
82Broad alveolar ridges (HP:0000187)2.09005986
83Focal seizures (HP:0007359)2.07725378
84Congenital hepatic fibrosis (HP:0002612)2.07086330
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06863783
86Renal hypoplasia (HP:0000089)2.05547074
87Short foot (HP:0001773)2.04560821
88Selective tooth agenesis (HP:0001592)2.04183626
89Focal motor seizures (HP:0011153)2.03578601
90Short clavicles (HP:0000894)2.02993017
91Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02382532
92Hypoplasia of the brainstem (HP:0002365)2.02382532
93Meckel diverticulum (HP:0002245)2.02190386
94Preaxial hand polydactyly (HP:0001177)2.02182175
95Shawl scrotum (HP:0000049)2.02059643
96Optic nerve hypoplasia (HP:0000609)1.99325958
97Micropenis (HP:0000054)1.96051435
98Nephroblastoma (Wilms tumor) (HP:0002667)1.95735422
99Pustule (HP:0200039)1.95574632
100Abnormal trabecular bone morphology (HP:0100671)1.94726376
101Aplasia/Hypoplasia of the clavicles (HP:0006710)1.94396357
102Tubulointerstitial abnormality (HP:0001969)1.94278567
103Stomach cancer (HP:0012126)1.93682784
104Oligodactyly (hands) (HP:0001180)1.92708615
105Abnormal number of incisors (HP:0011064)1.92621606
106Short middle phalanx of the 5th finger (HP:0004220)1.92608226
107Abnormal eating behavior (HP:0100738)1.91875942
108Exercise-induced muscle cramps (HP:0003710)1.91565462
109Embryonal renal neoplasm (HP:0011794)1.91173717
110Agitation (HP:0000713)1.91137909
111Tubular atrophy (HP:0000092)1.90162841
112Prostate neoplasm (HP:0100787)1.87581836
113Abnormality of the nasal septum (HP:0000419)1.87211075
114Abnormality of salivation (HP:0100755)1.86266533
115Hypsarrhythmia (HP:0002521)1.86226938
116Hypothermia (HP:0002045)1.86179341
117Abnormality of the corticospinal tract (HP:0002492)1.85867809
118Degeneration of the lateral corticospinal tracts (HP:0002314)1.85746964
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85746964
120Amblyopia (HP:0000646)1.85457727
121Vitreoretinal degeneration (HP:0000655)1.84574009
122Thyroid-stimulating hormone excess (HP:0002925)1.83984402
123Inability to walk (HP:0002540)1.83062949
124Congenital stationary night blindness (HP:0007642)1.82962910
125Progressive inability to walk (HP:0002505)1.82522213
126Epidermoid cyst (HP:0200040)1.82428143
127Supernumerary spleens (HP:0009799)1.82328063
128Spastic tetraplegia (HP:0002510)1.81560987
129Abnormality of male internal genitalia (HP:0000022)1.79233119
130Left ventricular hypertrophy (HP:0001712)1.79013389
131Cerebellar dysplasia (HP:0007033)1.78547230
132Absent epiphyses (HP:0010577)1.78015292
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78015292
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.77959282
135Prominent nasal bridge (HP:0000426)1.77805646
136Absent hand (HP:0004050)1.76831522
137EEG with generalized epileptiform discharges (HP:0011198)1.76124588
138Shallow orbits (HP:0000586)1.75597424
139Degeneration of anterior horn cells (HP:0002398)1.75310981
140Abnormality of the anterior horn cell (HP:0006802)1.75310981
141Neoplasm of the adrenal cortex (HP:0100641)1.75010334
142Myelodysplasia (HP:0002863)1.74410269
143Methylmalonic acidemia (HP:0002912)1.73744370
144Premature rupture of membranes (HP:0001788)1.72632527
145Abnormal respiratory motile cilium morphology (HP:0005938)1.72531172
146Abnormal respiratory epithelium morphology (HP:0012253)1.72531172
147Polymicrogyria (HP:0002126)1.72484873
148Pelvic girdle muscle weakness (HP:0003749)1.72219103
149Spinal muscular atrophy (HP:0007269)1.72028481
150Epileptiform EEG discharges (HP:0011182)1.71831862
151Abnormality of the 4th metacarpal (HP:0010012)1.71674487
152Anophthalmia (HP:0000528)1.71497941
153Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70251465
154Anal stenosis (HP:0002025)1.70241113
155Shoulder girdle muscle weakness (HP:0003547)1.69438706
156Genetic anticipation (HP:0003743)1.69212461
157Bifid tongue (HP:0010297)1.68650768
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.68437998
159Narrow nasal bridge (HP:0000446)1.66420819
160Aplasia/hypoplasia of the humerus (HP:0006507)1.60789082
161Tracheomalacia (HP:0002779)1.60129861
162Mutism (HP:0002300)1.60101149
163Abnormality of the radial head (HP:0003995)1.59195072
164Abnormality of the distal phalanges of the toes (HP:0010182)1.58309070
165Premature graying of hair (HP:0002216)1.58036027
166Aortic valve stenosis (HP:0001650)1.57819729
167Adrenal hypoplasia (HP:0000835)1.57163211
168Fibular hypoplasia (HP:0003038)1.57037093
169Dislocated radial head (HP:0003083)1.56336777
170Aplasia/Hypoplasia of the fibula (HP:0006492)1.55140100
171Short humerus (HP:0005792)1.55029824
172Short thumb (HP:0009778)1.54278074
173Alopecia of scalp (HP:0002293)1.54189734
174Diastasis recti (HP:0001540)1.54033255
175Abnormality of the umbilical cord (HP:0010881)1.53267818
176Congenital, generalized hypertrichosis (HP:0004540)1.52036589
177Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.50510502
178Increased number of teeth (HP:0011069)1.48986711
179Aplasia/Hypoplasia of the sternum (HP:0006714)1.48903747
180Ectopic kidney (HP:0000086)1.47965101
181Tracheoesophageal fistula (HP:0002575)1.47008821
182Duodenal stenosis (HP:0100867)1.46813694
183Small intestinal stenosis (HP:0012848)1.46813694
184Abnormality of the preputium (HP:0100587)1.46710014
185Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.45859704
186Broad phalanges of the hand (HP:0009768)1.45637680
187Abnormality of chromosome segregation (HP:0002916)1.45361400
188Hypoplasia of the maxilla (HP:0000327)1.44747503
189Volvulus (HP:0002580)1.44648631
190Abnormality of the musculature of the pelvis (HP:0001469)1.43936371
191Abnormality of the hip-girdle musculature (HP:0001445)1.43936371
192Oligodactyly (HP:0012165)1.43053255
193Abnormality of the phalanges of the hallux (HP:0010057)1.42981965
194Biconcave vertebral bodies (HP:0004586)1.42834363
195Broad finger (HP:0001500)1.42271669
196Hepatoblastoma (HP:0002884)1.41538637
197Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.41223798
198Midline defect of the nose (HP:0004122)1.40974248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.08418943
2BUB13.58611629
3BCR3.52952742
4MKNK23.40388929
5MAP3K43.33323689
6MKNK13.18556627
7WEE13.16066611
8WNK33.04531741
9MAP4K22.87540181
10MAP2K72.81976335
11ACVR1B2.72687175
12TRIM282.67823832
13TAOK22.59486699
14ERBB32.58295237
15AKT32.33033667
16DYRK32.20999520
17NEK22.20693535
18FRK2.13736966
19SRPK12.12600516
20EPHA42.11266792
21TGFBR22.02031341
22CDC71.94281071
23CCNB11.94233405
24YES11.83594796
25DDR21.68591165
26CSNK1G21.68310111
27PLK31.64494716
28CDK81.61159820
29MAP3K61.57395679
30TSSK61.55843139
31PAK31.54830842
32TGFBR11.54123623
33CDK31.53876789
34PLK11.49762453
35CDK71.39407468
36BCKDK1.38189700
37RPS6KA41.36228832
38MARK11.35564122
39PLK41.33221650
40IRAK31.30609293
41DYRK21.28487448
42CHEK21.28316271
43PIM21.28277241
44EIF2AK21.27456427
45NTRK31.24195147
46MAP2K41.22549264
47STK31.20267572
48ATR1.19691044
49PLK21.19024735
50EPHA31.12357340
51PNCK1.12004768
52DYRK1B1.08942507
53CDK191.07158877
54ADRBK21.06694575
55PIM11.06600211
56SIK21.06206304
57PRKCE1.04396507
58PINK11.03821115
59ZAK1.03755885
60MATK1.03732413
61UHMK11.03040668
62MAPK151.00115202
63CHUK0.99764372
64STK160.99428423
65SGK20.99303917
66BRSK20.99118921
67BMPR1B0.96946141
68EIF2AK30.96672353
69EPHB20.96192947
70GRK10.94516626
71EPHB10.94474714
72STK38L0.93401813
73DAPK20.92272438
74AURKB0.91948158
75EPHA20.90121058
76FGFR20.89917816
77KSR10.88590866
78BRD40.87707264
79INSRR0.81976108
80PRKCG0.81517562
81VRK10.80767815
82MINK10.79750386
83SIK30.79512216
84PAK60.79462669
85TTK0.79345977
86EIF2AK10.79100503
87CDK60.78900455
88MAPK130.76191595
89FLT30.74056431
90LATS20.72489601
91CSNK1A1L0.72390113
92FER0.72104069
93SGK2230.72096314
94SGK4940.72096314
95OXSR10.71514912
96PRPF4B0.70590086
97CLK10.70584039
98CDK120.69667013
99CDK20.69456526
100CHEK10.68107319
101CDK50.67118161
102KIT0.66391331
103PKN10.65434809
104CAMK2A0.65344977
105CAMKK20.64964003
106STK390.61567438
107CDK10.60844547
108WNK40.60370387
109BRSK10.60228777
110ICK0.59774220
111NUAK10.59464645
112PKN20.59355224
113PAK40.58872857
114MAP3K140.57818104
115CSNK1G30.57253346
116DYRK1A0.56658417
117PAK20.54605698
118GRK70.53787684
119SGK30.53494022
120TIE10.52647693
121MAP3K30.52170036
122ATM0.51188074
123STK100.50926057
124FGR0.50857398
125IRAK10.50315202
126PDGFRA0.49957995
127MAP2K30.49496018
128MAPK70.47602866
129IKBKB0.47460241
130MAPK90.47213981
131CAMK40.47179740
132CSNK1G10.46599339
133TNIK0.46523005
134MELK0.44455378
135CSNK1A10.43477682
136ERBB20.43431472
137FGFR10.40882177
138NTRK20.40478363
139ADRBK10.40461822
140RPS6KC10.40261888
141RPS6KL10.40261888
142PRKAA10.40094440
143PRKACA0.38818702
144ALK0.38679093
145PRKACB0.38573700
146RAF10.38240788
147RPS6KA60.37965822
148PRKCZ0.37838771
149CSNK2A10.37476700
150CDK90.37368458
151IRAK40.37360904
152PTK2B0.36694936
153CAMK2B0.36475969
154RPS6KB20.36268746
155CDK140.34851646
156PRKG10.34252022
157CDK180.33684614
158CSNK1D0.32600084
159CAMK10.31561615
160CAMK2D0.30048600
161MAP3K70.28679874
162RPS6KA50.28071125
163PHKG10.24997088
164PHKG20.24997088
165MAP3K50.24422827

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.62507085
2Nicotine addiction_Homo sapiens_hsa050333.48702519
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.31347484
4Spliceosome_Homo sapiens_hsa030402.63242877
5Protein export_Homo sapiens_hsa030602.61425234
6Steroid biosynthesis_Homo sapiens_hsa001002.54378166
7Cell cycle_Homo sapiens_hsa041102.50329199
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47059280
9DNA replication_Homo sapiens_hsa030302.42101907
10Base excision repair_Homo sapiens_hsa034102.36833278
11Butanoate metabolism_Homo sapiens_hsa006502.23466292
12Mismatch repair_Homo sapiens_hsa034302.18581301
13GABAergic synapse_Homo sapiens_hsa047272.18123664
14RNA polymerase_Homo sapiens_hsa030202.18088355
15RNA transport_Homo sapiens_hsa030132.17785821
16Phototransduction_Homo sapiens_hsa047442.16838871
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14908750
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12397447
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09744434
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07436143
21p53 signaling pathway_Homo sapiens_hsa041151.88947189
22Propanoate metabolism_Homo sapiens_hsa006401.82992888
23Glutamatergic synapse_Homo sapiens_hsa047241.76273186
24mRNA surveillance pathway_Homo sapiens_hsa030151.73413151
25Basal transcription factors_Homo sapiens_hsa030221.73073363
26Fanconi anemia pathway_Homo sapiens_hsa034601.69199633
27Nucleotide excision repair_Homo sapiens_hsa034201.68871977
28Taste transduction_Homo sapiens_hsa047421.68577073
29Morphine addiction_Homo sapiens_hsa050321.67659790
30Cocaine addiction_Homo sapiens_hsa050301.65784385
31Dopaminergic synapse_Homo sapiens_hsa047281.61352171
32Circadian entrainment_Homo sapiens_hsa047131.59445040
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52145147
34Nitrogen metabolism_Homo sapiens_hsa009101.51894798
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51786302
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50138785
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47860775
38Homologous recombination_Homo sapiens_hsa034401.46417829
39Vitamin B6 metabolism_Homo sapiens_hsa007501.42218490
40Ether lipid metabolism_Homo sapiens_hsa005651.38833291
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34219940
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31619938
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30697753
44Circadian rhythm_Homo sapiens_hsa047101.29411295
45MicroRNAs in cancer_Homo sapiens_hsa052061.29142546
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28808949
47Synaptic vesicle cycle_Homo sapiens_hsa047211.28665152
48Colorectal cancer_Homo sapiens_hsa052101.27712678
49Hippo signaling pathway_Homo sapiens_hsa043901.26237726
50Insulin secretion_Homo sapiens_hsa049111.25170479
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24163241
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23621155
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.22605630
54Epstein-Barr virus infection_Homo sapiens_hsa051691.20954897
55Herpes simplex infection_Homo sapiens_hsa051681.20084905
56TGF-beta signaling pathway_Homo sapiens_hsa043501.19216662
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18705417
58Pyrimidine metabolism_Homo sapiens_hsa002401.17769976
59Linoleic acid metabolism_Homo sapiens_hsa005911.16332739
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16327366
61Peroxisome_Homo sapiens_hsa041461.15892564
62RNA degradation_Homo sapiens_hsa030181.15287083
63Small cell lung cancer_Homo sapiens_hsa052221.13207732
64Serotonergic synapse_Homo sapiens_hsa047261.12802922
65Collecting duct acid secretion_Homo sapiens_hsa049661.11865722
66Amphetamine addiction_Homo sapiens_hsa050311.10957231
67Notch signaling pathway_Homo sapiens_hsa043301.09037979
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.05133793
69Oocyte meiosis_Homo sapiens_hsa041141.03726993
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02785451
71Leishmaniasis_Homo sapiens_hsa051401.02417235
72Basal cell carcinoma_Homo sapiens_hsa052171.01948563
73Chronic myeloid leukemia_Homo sapiens_hsa052201.01141616
74HTLV-I infection_Homo sapiens_hsa051661.00161990
75Oxidative phosphorylation_Homo sapiens_hsa001900.99626118
76Olfactory transduction_Homo sapiens_hsa047400.98848039
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96945324
78Hedgehog signaling pathway_Homo sapiens_hsa043400.96425312
79Hepatitis B_Homo sapiens_hsa051610.96003840
80Legionellosis_Homo sapiens_hsa051340.95853700
81Parkinsons disease_Homo sapiens_hsa050120.95712992
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93358057
83Long-term depression_Homo sapiens_hsa047300.92834586
84Cholinergic synapse_Homo sapiens_hsa047250.91616036
85Adherens junction_Homo sapiens_hsa045200.87753957
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87142352
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86700810
88Shigellosis_Homo sapiens_hsa051310.86273473
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86206415
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85735907
91Cardiac muscle contraction_Homo sapiens_hsa042600.85486727
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84789594
93Measles_Homo sapiens_hsa051620.83935820
94Wnt signaling pathway_Homo sapiens_hsa043100.83613689
95FoxO signaling pathway_Homo sapiens_hsa040680.83597050
96Prostate cancer_Homo sapiens_hsa052150.83109362
97Osteoclast differentiation_Homo sapiens_hsa043800.82020143
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.81639698
99Endometrial cancer_Homo sapiens_hsa052130.80856523
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80277820
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79574737
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79499553
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79217793
104Pancreatic cancer_Homo sapiens_hsa052120.78605161
105Influenza A_Homo sapiens_hsa051640.76683781
106TNF signaling pathway_Homo sapiens_hsa046680.76423847
107Gap junction_Homo sapiens_hsa045400.76308985
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.76069503
109Apoptosis_Homo sapiens_hsa042100.76023185
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75370535
111Viral carcinogenesis_Homo sapiens_hsa052030.74851886
112mTOR signaling pathway_Homo sapiens_hsa041500.70890061
113Proteoglycans in cancer_Homo sapiens_hsa052050.70016724
114Purine metabolism_Homo sapiens_hsa002300.69780347
115Pathways in cancer_Homo sapiens_hsa052000.69272320
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68363689
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67497440
118Asthma_Homo sapiens_hsa053100.66809034
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66714860
120Fatty acid metabolism_Homo sapiens_hsa012120.65594618
121B cell receptor signaling pathway_Homo sapiens_hsa046620.65499402
122Regulation of autophagy_Homo sapiens_hsa041400.65250005
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.65035151
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64628967
125ABC transporters_Homo sapiens_hsa020100.64164068
126Allograft rejection_Homo sapiens_hsa053300.62606124
127Viral myocarditis_Homo sapiens_hsa054160.61996750
128Fatty acid elongation_Homo sapiens_hsa000620.61004161
129Renal cell carcinoma_Homo sapiens_hsa052110.60944222
130Acute myeloid leukemia_Homo sapiens_hsa052210.59988203
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59910614
132beta-Alanine metabolism_Homo sapiens_hsa004100.59110977
133HIF-1 signaling pathway_Homo sapiens_hsa040660.58733726
134cAMP signaling pathway_Homo sapiens_hsa040240.58588917
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.58279566
136Huntingtons disease_Homo sapiens_hsa050160.57331801
137MAPK signaling pathway_Homo sapiens_hsa040100.57169050
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57150185
139Axon guidance_Homo sapiens_hsa043600.57129182
140Toxoplasmosis_Homo sapiens_hsa051450.56194736
141Bladder cancer_Homo sapiens_hsa052190.54217172
142Salivary secretion_Homo sapiens_hsa049700.53441927
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53149744
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52757094
145Arginine and proline metabolism_Homo sapiens_hsa003300.52415750
146Type II diabetes mellitus_Homo sapiens_hsa049300.52344844
147Melanoma_Homo sapiens_hsa052180.51340018
148Malaria_Homo sapiens_hsa051440.51252247
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50738749
150Salmonella infection_Homo sapiens_hsa051320.49903852
151Focal adhesion_Homo sapiens_hsa045100.49848090
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49833280
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49445363
154Selenocompound metabolism_Homo sapiens_hsa004500.48985393
155Tryptophan metabolism_Homo sapiens_hsa003800.48741496
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.48710715
157Proteasome_Homo sapiens_hsa030500.48288560
158Choline metabolism in cancer_Homo sapiens_hsa052310.46692003
159Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46486078
160Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45725015
161Vitamin digestion and absorption_Homo sapiens_hsa049770.45669434
162Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45502532
163RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44698282
164Rap1 signaling pathway_Homo sapiens_hsa040150.44612224
165Melanogenesis_Homo sapiens_hsa049160.44213809
166Hematopoietic cell lineage_Homo sapiens_hsa046400.44143329
167Dorso-ventral axis formation_Homo sapiens_hsa043200.43929227
168Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43642129
169Ras signaling pathway_Homo sapiens_hsa040140.42236813
170Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41487131
171Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40870158
172Oxytocin signaling pathway_Homo sapiens_hsa049210.40195136
173Alzheimers disease_Homo sapiens_hsa050100.39376639
174Calcium signaling pathway_Homo sapiens_hsa040200.38169218
175Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37967449
176Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37792499
177Steroid hormone biosynthesis_Homo sapiens_hsa001400.37429859
178Renin secretion_Homo sapiens_hsa049240.36567143
179Alcoholism_Homo sapiens_hsa050340.36323634
180Metabolic pathways_Homo sapiens_hsa011000.35782672
181Tight junction_Homo sapiens_hsa045300.34481357
182Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33482842
183Retinol metabolism_Homo sapiens_hsa008300.33056268
184Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32223594
185Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31306724

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