WSB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.20553318
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09887457
3locomotory exploration behavior (GO:0035641)4.96886680
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63418023
5layer formation in cerebral cortex (GO:0021819)4.47733179
6vocalization behavior (GO:0071625)4.36562182
7glutamate secretion (GO:0014047)4.33418327
8synaptic vesicle exocytosis (GO:0016079)4.28042745
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.27168099
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24078816
11regulation of synaptic vesicle exocytosis (GO:2000300)4.17750102
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09970868
13regulation of synapse structural plasticity (GO:0051823)3.95278843
14regulation of glutamate receptor signaling pathway (GO:1900449)3.87599891
15proline transport (GO:0015824)3.81783778
16exploration behavior (GO:0035640)3.78788576
17activation of protein kinase A activity (GO:0034199)3.70231245
18regulation of synaptic vesicle transport (GO:1902803)3.64590366
19dendritic spine morphogenesis (GO:0060997)3.61339160
20negative regulation of dendrite morphogenesis (GO:0050774)3.56468803
21protein localization to synapse (GO:0035418)3.53717291
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51407535
23regulation of neuronal synaptic plasticity (GO:0048168)3.50148160
24neurotransmitter secretion (GO:0007269)3.48199332
25sodium ion export (GO:0071436)3.34046687
26positive regulation of neurotransmitter transport (GO:0051590)3.33588450
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31545308
28cellular potassium ion homeostasis (GO:0030007)3.30782158
29dendrite morphogenesis (GO:0048813)3.28071915
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.19687078
31cell communication by electrical coupling (GO:0010644)3.15762701
32neuron cell-cell adhesion (GO:0007158)3.15364473
33neuronal action potential propagation (GO:0019227)3.10251870
34neuromuscular process controlling balance (GO:0050885)3.08072579
35regulation of dendritic spine morphogenesis (GO:0061001)3.05857203
36gamma-aminobutyric acid transport (GO:0015812)3.03167762
37neuron recognition (GO:0008038)3.03047811
38positive regulation of actin filament depolymerization (GO:0030836)3.03015221
39regulation of ARF protein signal transduction (GO:0032012)3.02732225
40neurotransmitter-gated ion channel clustering (GO:0072578)3.00301285
41negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99027874
42positive regulation of synapse maturation (GO:0090129)2.98715506
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96038954
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94203744
45vesicle transport along microtubule (GO:0047496)2.92039605
46cytoskeletal anchoring at plasma membrane (GO:0007016)2.87745033
47cerebellar Purkinje cell layer development (GO:0021680)2.87734494
48negative regulation of dendrite development (GO:2000171)2.85664128
49synaptic transmission, glutamatergic (GO:0035249)2.85559399
50long-term memory (GO:0007616)2.85533122
51righting reflex (GO:0060013)2.85023967
52axonal fasciculation (GO:0007413)2.83013772
53regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81246273
54regulation of synaptic plasticity (GO:0048167)2.77596673
55regulation of neurotransmitter transport (GO:0051588)2.77396200
56alanine transport (GO:0032328)2.77294212
57potassium ion homeostasis (GO:0055075)2.77081436
58glutamate receptor signaling pathway (GO:0007215)2.76392746
59organelle transport along microtubule (GO:0072384)2.75921901
60positive regulation of membrane potential (GO:0045838)2.74934961
61plasma membrane repair (GO:0001778)2.73713630
62regulation of cell communication by electrical coupling (GO:0010649)2.73471828
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.72236175
64dendritic spine organization (GO:0097061)2.71889916
65postsynaptic membrane organization (GO:0001941)2.71373559
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71352269
67astrocyte differentiation (GO:0048708)2.68329209
68regulation of postsynaptic membrane potential (GO:0060078)2.67406741
69neurotransmitter transport (GO:0006836)2.66434929
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66037806
71clathrin coat assembly (GO:0048268)2.65731718
72synaptic vesicle endocytosis (GO:0048488)2.65161225
73positive regulation of protein autophosphorylation (GO:0031954)2.65135944
74cell communication involved in cardiac conduction (GO:0086065)2.64763382
75neuron-neuron synaptic transmission (GO:0007270)2.64660935
76cell migration in hindbrain (GO:0021535)2.64634436
77regulation of vesicle fusion (GO:0031338)2.63018016
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.62474086
79regulation of neurotransmitter secretion (GO:0046928)2.61528884
80nerve growth factor signaling pathway (GO:0038180)2.59561150
81mating behavior (GO:0007617)2.59477162
82positive regulation of synaptic transmission, GABAergic (GO:0032230)2.55621192
83glycine transport (GO:0015816)2.55475401
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55337895
85prepulse inhibition (GO:0060134)2.55219449
86axon extension (GO:0048675)2.54716319
87regulation of dendritic spine development (GO:0060998)2.54529995
88innervation (GO:0060384)2.54009360
89membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52989083
90cerebellar granule cell differentiation (GO:0021707)2.52203918
91positive regulation of axon extension (GO:0045773)2.52001102
92regulation of Rac protein signal transduction (GO:0035020)2.51996031
93auditory behavior (GO:0031223)2.50961804
94positive regulation of fibroblast migration (GO:0010763)2.49194705
95positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48936905
96neuromuscular synaptic transmission (GO:0007274)2.47714924
97pyrimidine nucleobase catabolic process (GO:0006208)2.45864021
98regulation of neurotransmitter levels (GO:0001505)2.45165261
99calcium ion-dependent exocytosis (GO:0017156)2.44268464
100regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.43672179
101macroautophagy (GO:0016236)2.43017349
102insulin secretion (GO:0030073)2.42809939
103signal release (GO:0023061)2.41832362
104presynaptic membrane assembly (GO:0097105)2.41687353
105detection of calcium ion (GO:0005513)2.41481534
106membrane depolarization during action potential (GO:0086010)2.41344693
107long-term synaptic potentiation (GO:0060291)2.41221455
108positive regulation of dendritic spine development (GO:0060999)2.41122346
109inositol phosphate catabolic process (GO:0071545)2.41040658
110axon cargo transport (GO:0008088)2.40914291
111response to auditory stimulus (GO:0010996)2.40712800
112potassium ion import (GO:0010107)2.40615996
113neuronal ion channel clustering (GO:0045161)2.40465351
114regulation of clathrin-mediated endocytosis (GO:2000369)2.39246377
115membrane repolarization (GO:0086009)2.39129539
116regulation of synaptic transmission, glutamatergic (GO:0051966)2.38882751
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.38779142
118synapse organization (GO:0050808)2.38367187
119positive regulation of neurotransmitter secretion (GO:0001956)2.38335653
120establishment of nucleus localization (GO:0040023)2.37208348
121neuron projection extension (GO:1990138)2.37126280
122negative regulation of microtubule polymerization (GO:0031115)2.36194221
123neuromuscular process (GO:0050905)2.35998741
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35836100
125membrane depolarization (GO:0051899)2.35314001
126transferrin transport (GO:0033572)2.34168039
127glycosphingolipid biosynthetic process (GO:0006688)2.33576617
128presynaptic membrane organization (GO:0097090)2.33506579
129melanin biosynthetic process (GO:0042438)2.33426463
130startle response (GO:0001964)2.32784869
131regulation of neurotransmitter uptake (GO:0051580)2.31748654
132regulation of calcium ion-dependent exocytosis (GO:0017158)2.30580000
133ferric iron transport (GO:0015682)2.27774471
134trivalent inorganic cation transport (GO:0072512)2.27774471
135response to gravity (GO:0009629)2.27361204
136inositol phosphate-mediated signaling (GO:0048016)2.26268646
137establishment of synaptic vesicle localization (GO:0097480)2.25969975
138synaptic vesicle transport (GO:0048489)2.25969975
139synaptic transmission (GO:0007268)2.22380604
140chemosensory behavior (GO:0007635)2.22164342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.20257129
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57983419
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57174766
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40579335
5DROSHA_22980978_ChIP-Seq_HELA_Human2.35349021
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35231646
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35231646
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32395327
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31435296
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.30154501
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28610018
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27633976
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22425077
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19666913
15REST_21632747_ChIP-Seq_MESCs_Mouse2.18721192
16GBX2_23144817_ChIP-Seq_PC3_Human2.17262992
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14597402
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04385909
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02576901
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99889370
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.99432627
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97019362
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.93507263
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.86046179
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.80279900
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74904779
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.73083528
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.67893156
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67204098
30* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60059399
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59378156
32KDM2B_26808549_Chip-Seq_K562_Human1.57829272
33* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53304258
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49862724
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48561047
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47072079
37AR_21572438_ChIP-Seq_LNCaP_Human1.46707029
38P300_19829295_ChIP-Seq_ESCs_Human1.43175369
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.41317756
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38500036
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37075941
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36737150
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35313963
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34764235
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34515781
46* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33174922
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32521044
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31535241
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31247293
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30926439
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30331327
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.30215924
53* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29862548
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25040326
55ZNF274_21170338_ChIP-Seq_K562_Hela1.24016697
56TAF15_26573619_Chip-Seq_HEK293_Human1.23707832
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23010709
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.22287818
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20249771
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.19578272
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19045890
62CJUN_26792858_Chip-Seq_BT549_Human1.18562262
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18111779
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16539077
65SMAD4_21799915_ChIP-Seq_A2780_Human1.16258970
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15664719
67TP53_18474530_ChIP-ChIP_U2OS_Human1.15522413
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.14256741
69P53_22387025_ChIP-Seq_ESCs_Mouse1.13911929
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12419411
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11971949
72AHR_22903824_ChIP-Seq_MCF-7_Human1.11862497
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11833131
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.11678384
75AR_19668381_ChIP-Seq_PC3_Human1.11148778
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10178017
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.10141925
78* TCF4_23295773_ChIP-Seq_U87_Human1.09768613
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08390595
80* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07518887
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06395113
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.06074493
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.04280585
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.03858141
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03785001
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03559086
87LXR_22292898_ChIP-Seq_THP-1_Human1.02454412
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02190289
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01594094
90KDM2B_26808549_Chip-Seq_REH_Human1.01211203
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.00585878
92BCAT_22108803_ChIP-Seq_LS180_Human1.00473845
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.00189948
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00172731
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99607686
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97466416
97* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96942806
98* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96810312
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96584387
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96502264
101CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95501403
102EZH2_27294783_Chip-Seq_NPCs_Mouse0.95270854
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.95269825
104* JUN_21703547_ChIP-Seq_K562_Human0.95217217
105RXR_22108803_ChIP-Seq_LS180_Human0.94855573
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.94810193
107SMAD_19615063_ChIP-ChIP_OVARY_Human0.94627573
108STAT3_18555785_Chip-Seq_ESCs_Mouse0.94043349
109WT1_19549856_ChIP-ChIP_CCG9911_Human0.94025263
110SOX2_20726797_ChIP-Seq_SW620_Human0.93680855
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93289235
112* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93279741
113ZNF263_19887448_ChIP-Seq_K562_Human0.93106889
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92289088
115* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92060047
116CTCF_27219007_Chip-Seq_Bcells_Human0.91949196
117AR_25329375_ChIP-Seq_VCAP_Human0.91371224
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.91047643
119* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91023176
120STAT3_23295773_ChIP-Seq_U87_Human0.90608076
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90531481
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.88651783
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88579541
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.87242719
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.86717316
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86682988
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84824483
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84824483
129* KDM2B_26808549_Chip-Seq_DND41_Human0.84771391
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84541958
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83949102
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83828176
133TP53_16413492_ChIP-PET_HCT116_Human0.83711209
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82947211
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82855985
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82331998
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81850951
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81786972
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80530205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22601428
2MP0004270_analgesia3.79606815
3MP0003635_abnormal_synaptic_transmissio3.61914956
4MP0009780_abnormal_chondrocyte_physiolo3.06648477
5MP0003880_abnormal_central_pattern3.04079584
6MP0002063_abnormal_learning/memory/cond2.95702039
7MP0009745_abnormal_behavioral_response2.65318524
8MP0004858_abnormal_nervous_system2.56143292
9MP0002064_seizures2.45338638
10MP0002734_abnormal_mechanical_nocicepti2.38829594
11MP0003329_amyloid_beta_deposits2.36672796
12MP0002909_abnormal_adrenal_gland2.36045478
13MP0005257_abnormal_intraocular_pressure2.34876098
14MP0001968_abnormal_touch/_nociception2.33723961
15MP0002572_abnormal_emotion/affect_behav2.24793752
16MP0009046_muscle_twitch2.12848615
17MP0002822_catalepsy2.05370965
18MP0005423_abnormal_somatic_nervous1.97307183
19MP0003787_abnormal_imprinting1.97185438
20MP0001440_abnormal_grooming_behavior1.96277027
21MP0002733_abnormal_thermal_nociception1.95887036
22MP0002735_abnormal_chemical_nociception1.88498107
23MP0002638_abnormal_pupillary_reflex1.84602008
24MP0001486_abnormal_startle_reflex1.84526195
25MP0003283_abnormal_digestive_organ1.81017017
26MP0000751_myopathy1.80974445
27MP0002272_abnormal_nervous_system1.75105755
28MP0000013_abnormal_adipose_tissue1.73904566
29MP0003879_abnormal_hair_cell1.71980620
30MP0004811_abnormal_neuron_physiology1.67992604
31MP0002736_abnormal_nociception_after1.67932334
32MP0001970_abnormal_pain_threshold1.67507020
33MP0001501_abnormal_sleep_pattern1.62466359
34MP0000569_abnormal_digit_pigmentation1.57508237
35MP0002837_dystrophic_cardiac_calcinosis1.56384088
36MP0000778_abnormal_nervous_system1.55254454
37MP0008961_abnormal_basal_metabolism1.51001909
38MP0005623_abnormal_meninges_morphology1.50702062
39MP0002184_abnormal_innervation1.49044977
40MP0005171_absent_coat_pigmentation1.48343386
41MP0002067_abnormal_sensory_capabilities1.43026084
42MP0000604_amyloidosis1.42722871
43MP0008569_lethality_at_weaning1.39313390
44MP0000372_irregular_coat_pigmentation1.39222157
45MP0004924_abnormal_behavior1.38721081
46MP0005386_behavior/neurological_phenoty1.38721081
47MP0010234_abnormal_vibrissa_follicle1.38590651
48MP0000955_abnormal_spinal_cord1.38174807
49MP0002557_abnormal_social/conspecific_i1.36838101
50MP0004885_abnormal_endolymph1.36129744
51MP0004130_abnormal_muscle_cell1.33371179
52MP0003633_abnormal_nervous_system1.26860299
53MP0003705_abnormal_hypodermis_morpholog1.23505826
54MP0002066_abnormal_motor_capabilities/c1.23419018
55MP0004510_myositis1.22863630
56MP0003123_paternal_imprinting1.21966539
57MP0010386_abnormal_urinary_bladder1.21075611
58MP0001905_abnormal_dopamine_level1.21040071
59MP0003075_altered_response_to1.19755198
60MP0005646_abnormal_pituitary_gland1.18711181
61MP0003172_abnormal_lysosome_physiology1.13338071
62MP0005167_abnormal_blood-brain_barrier1.12718150
63MP0002882_abnormal_neuron_morphology1.11087955
64MP0000749_muscle_degeneration1.10055350
65MP0004043_abnormal_pH_regulation1.09990862
66MP0002102_abnormal_ear_morphology1.09549440
67MP0004145_abnormal_muscle_electrophysio1.09399337
68MP0005535_abnormal_body_temperature1.05651661
69MP0002090_abnormal_vision1.04998517
70MP0000747_muscle_weakness1.04670162
71MP0000015_abnormal_ear_pigmentation1.03652427
72MP0003634_abnormal_glial_cell1.02598504
73MP0003631_nervous_system_phenotype1.00620131
74MP0001944_abnormal_pancreas_morphology1.00392202
75MP0001502_abnormal_circadian_rhythm0.97129874
76MP0002876_abnormal_thyroid_physiology0.96922808
77MP0005248_abnormal_Harderian_gland0.95636659
78MP0006276_abnormal_autonomic_nervous0.92316353
79MP0002877_abnormal_melanocyte_morpholog0.92092953
80MP0004233_abnormal_muscle_weight0.91763432
81MP0003303_peritoneal_inflammation0.91297662
82MP0004085_abnormal_heartbeat0.90476949
83MP0005551_abnormal_eye_electrophysiolog0.89786610
84MP0003690_abnormal_glial_cell0.88227023
85MP0005408_hypopigmentation0.88102140
86MP0004484_altered_response_of0.87966673
87MP0005174_abnormal_tail_pigmentation0.87398695
88MP0002152_abnormal_brain_morphology0.87129545
89MP0002069_abnormal_eating/drinking_beha0.86037316
90MP0005187_abnormal_penis_morphology0.85755756
91MP0006054_spinal_hemorrhage0.84917399
92MP0004036_abnormal_muscle_relaxation0.82914866
93MP0001756_abnormal_urination0.82512759
94MP0008874_decreased_physiological_sensi0.82161056
95MP0004084_abnormal_cardiac_muscle0.81690422
96MP0001984_abnormal_olfaction0.81447478
97MP0003045_fibrosis0.81443686
98MP0001299_abnormal_eye_distance/0.81172057
99MP0000003_abnormal_adipose_tissue0.80608638
100MP0004215_abnormal_myocardial_fiber0.80392117
101MP0005620_abnormal_muscle_contractility0.78205209
102MP0002938_white_spotting0.77152432
103MP0002896_abnormal_bone_mineralization0.74387893
104MP0001348_abnormal_lacrimal_gland0.74368135
105MP0000538_abnormal_urinary_bladder0.74088703
106MP0010678_abnormal_skin_adnexa0.73970500
107MP0004087_abnormal_muscle_fiber0.73966816
108MP0001177_atelectasis0.73391303
109MP0003632_abnormal_nervous_system0.72647499
110MP0008438_abnormal_cutaneous_collagen0.72574082
111MP0005379_endocrine/exocrine_gland_phen0.72269700
112MP0005253_abnormal_eye_physiology0.71301242
113MP0005645_abnormal_hypothalamus_physiol0.70923633
114MP0002693_abnormal_pancreas_physiology0.69925424
115MP0003195_calcinosis0.69911979
116MP0000920_abnormal_myelination0.69251863
117MP0002229_neurodegeneration0.68920238
118MP0003950_abnormal_plasma_membrane0.68532753
119MP0002972_abnormal_cardiac_muscle0.67526283
120MP0002234_abnormal_pharynx_morphology0.67104427
121MP0003868_abnormal_feces_composition0.66167670
122MP0002078_abnormal_glucose_homeostasis0.65843687
123MP0003137_abnormal_impulse_conducting0.64642713
124MP0005166_decreased_susceptibility_to0.64055315
125MP0001765_abnormal_ion_homeostasis0.61521429
126MP0002269_muscular_atrophy0.60942826
127MP0003122_maternal_imprinting0.60712692
128MP0003091_abnormal_cell_migration0.60706732

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.17201278
2Focal motor seizures (HP:0011153)4.43893463
3Visual hallucinations (HP:0002367)4.28329861
4Focal seizures (HP:0007359)3.98838954
5Supranuclear gaze palsy (HP:0000605)3.62758600
6Action tremor (HP:0002345)3.32978681
7Aplasia/Hypoplasia of the fovea (HP:0008060)3.28444882
8Hypoplasia of the fovea (HP:0007750)3.28444882
9Cerebral inclusion bodies (HP:0100314)3.24035825
10Ankle clonus (HP:0011448)3.09811652
11Neurofibrillary tangles (HP:0002185)3.01228660
12Epileptic encephalopathy (HP:0200134)2.95998066
13Generalized tonic-clonic seizures (HP:0002069)2.95517250
14Papilledema (HP:0001085)2.93344901
15Poor eye contact (HP:0000817)2.88313127
16Absence seizures (HP:0002121)2.88312545
17Atonic seizures (HP:0010819)2.87891744
18Impaired social interactions (HP:0000735)2.81986942
19Abnormal social behavior (HP:0012433)2.81986942
20Mutism (HP:0002300)2.81065517
21Abnormality of the lower motor neuron (HP:0002366)2.72097672
22Depression (HP:0000716)2.69506198
23Abnormality of the fovea (HP:0000493)2.59966536
24Insidious onset (HP:0003587)2.57938597
25Termporal pattern (HP:0011008)2.57938597
26Progressive cerebellar ataxia (HP:0002073)2.52778357
27Urinary urgency (HP:0000012)2.52032226
28Dialeptic seizures (HP:0011146)2.51697132
29Aplasia/Hypoplasia of the macula (HP:0008059)2.49299329
30Urinary bladder sphincter dysfunction (HP:0002839)2.49262163
31Impaired vibration sensation in the lower limbs (HP:0002166)2.46974048
32Postural instability (HP:0002172)2.46436143
33Torticollis (HP:0000473)2.44409740
34Rapidly progressive (HP:0003678)2.37698426
35Hyperinsulinemic hypoglycemia (HP:0000825)2.36866337
36Lower limb amyotrophy (HP:0007210)2.35845895
37Diminished movement (HP:0002374)2.35793242
38Aplasia/Hypoplasia affecting the retina (HP:0008061)2.32510529
39Bundle branch block (HP:0011710)2.32254779
40Anxiety (HP:0000739)2.31876881
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31758560
42Resting tremor (HP:0002322)2.30644678
43Megalencephaly (HP:0001355)2.29208065
44Abnormal eating behavior (HP:0100738)2.28119142
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27919156
46Upper limb amyotrophy (HP:0009129)2.25731124
47Distal upper limb amyotrophy (HP:0007149)2.25731124
48Febrile seizures (HP:0002373)2.25414872
49Ventricular fibrillation (HP:0001663)2.25301408
50Hamartoma of the eye (HP:0010568)2.25268306
51Dysdiadochokinesis (HP:0002075)2.24548471
52Agitation (HP:0000713)2.24211590
53Pheochromocytoma (HP:0002666)2.23413330
54Abnormality of liposaccharide metabolism (HP:0010968)2.22479684
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.22479684
56Abnormality of glycolipid metabolism (HP:0010969)2.22479684
57Amblyopia (HP:0000646)2.21582035
58EEG with generalized epileptiform discharges (HP:0011198)2.19316756
59Ocular albinism (HP:0001107)2.17680683
60Hypsarrhythmia (HP:0002521)2.17348918
61Heterochromia iridis (HP:0001100)2.17295422
62Epileptiform EEG discharges (HP:0011182)2.17152460
63Hypokinesia (HP:0002375)2.15660350
64Focal dystonia (HP:0004373)2.12249353
65Dysmetria (HP:0001310)2.11973333
66Sudden death (HP:0001699)2.11782317
67Tetraplegia (HP:0002445)2.11298213
68Blue irides (HP:0000635)2.10875972
69Tongue fasciculations (HP:0001308)2.09156346
70Apathy (HP:0000741)2.09061634
71Broad-based gait (HP:0002136)2.08518137
72Iris hypopigmentation (HP:0007730)2.08190611
73Intention tremor (HP:0002080)2.08004375
74Achilles tendon contracture (HP:0001771)2.06498925
75Hypothermia (HP:0002045)2.06308732
76Amyotrophic lateral sclerosis (HP:0007354)2.02953057
77Delayed gross motor development (HP:0002194)2.02764213
78Akinesia (HP:0002304)2.02401726
79Ketoacidosis (HP:0001993)2.02369951
80Drooling (HP:0002307)2.02010343
81Excessive salivation (HP:0003781)2.02010343
82Hypoglycemic coma (HP:0001325)2.01868365
83Hyperglycemia (HP:0003074)2.01596875
84Truncal ataxia (HP:0002078)2.01256343
85Neuronal loss in central nervous system (HP:0002529)2.00834197
86Delusions (HP:0000746)1.99682662
87Hyporeflexia of lower limbs (HP:0002600)1.97539875
88Calf muscle hypertrophy (HP:0008981)1.97421137
89Craniofacial dystonia (HP:0012179)1.96955462
90Congenital sensorineural hearing impairment (HP:0008527)1.96942217
91Lower limb muscle weakness (HP:0007340)1.96683279
92Congenital glaucoma (HP:0001087)1.96628835
93Abnormality of the Achilles tendon (HP:0005109)1.96306885
94Muscular hypotonia of the trunk (HP:0008936)1.96117698
95Dysmetric saccades (HP:0000641)1.95904949
96Hand muscle atrophy (HP:0009130)1.95821668
97Exercise-induced myalgia (HP:0003738)1.95002324
98Bradykinesia (HP:0002067)1.94885814
99Hypercortisolism (HP:0001578)1.94416128
100Gaze-evoked nystagmus (HP:0000640)1.94347356
101Spastic gait (HP:0002064)1.93142137
102Hemiplegia (HP:0002301)1.90509456
103Genetic anticipation (HP:0003743)1.89956919
104Spastic tetraparesis (HP:0001285)1.89583977
105Abnormality of the corticospinal tract (HP:0002492)1.89566013
106Fetal akinesia sequence (HP:0001989)1.89215352
107Diminished motivation (HP:0000745)1.88466357
108Bronchomalacia (HP:0002780)1.87786505
109Stereotypic behavior (HP:0000733)1.87497939
110Enlarged penis (HP:0000040)1.87369249
111Obstructive sleep apnea (HP:0002870)1.86189029
112Diplopia (HP:0000651)1.84563399
113Abnormality of binocular vision (HP:0011514)1.84563399
114Hyperventilation (HP:0002883)1.84504722
115Insulin-resistant diabetes mellitus (HP:0000831)1.83633950
116Insomnia (HP:0100785)1.83575384
117Hemiparesis (HP:0001269)1.82855712
118Frequent falls (HP:0002359)1.82823890
119Lower limb asymmetry (HP:0100559)1.82666033
120Postural tremor (HP:0002174)1.82559988
121Generalized myoclonic seizures (HP:0002123)1.81866960
122Absent speech (HP:0001344)1.81074520
123Status epilepticus (HP:0002133)1.80967451
124Neuroendocrine neoplasm (HP:0100634)1.79651191
125Syncope (HP:0001279)1.79099538
126Inappropriate behavior (HP:0000719)1.78986384
127Hydroxyprolinuria (HP:0003080)1.78799110
128Abnormality of proline metabolism (HP:0010907)1.78799110
129Increased cerebral lipofuscin (HP:0011813)1.78383138
130Difficulty running (HP:0009046)1.78059168
131Turricephaly (HP:0000262)1.77938461
132Macroorchidism (HP:0000053)1.77412319
133Clonus (HP:0002169)1.76979699
134Lymphangioma (HP:0100764)1.76861783
135Cardiovascular calcification (HP:0011915)1.76223695
136Limb dystonia (HP:0002451)1.75695106
137Hypoventilation (HP:0002791)1.75489887
138Mitral stenosis (HP:0001718)1.75457921
139Muscle fibrillation (HP:0010546)1.75172429
140Prolonged QT interval (HP:0001657)1.75016883
141Polyphagia (HP:0002591)1.74454731
142Buphthalmos (HP:0000557)1.74448324
143Global brain atrophy (HP:0002283)1.73849115
144Muscle hypertrophy of the lower extremities (HP:0008968)1.73829535
145Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73513422
146Abnormality of polysaccharide metabolism (HP:0011012)1.73513422
147Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73513422
148Conjunctival hamartoma (HP:0100780)1.73250737
149Increased variability in muscle fiber diameter (HP:0003557)1.71330903
150Neoplasm of the peripheral nervous system (HP:0100007)1.71097202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.81552778
2MARK13.73586843
3NTRK33.27645209
4EPHA43.18554697
5DAPK22.77221012
6CASK2.69150375
7KSR22.55977341
8PRKD32.46749895
9MINK12.30649854
10PAK62.29343207
11TRIM282.26222114
12NTRK12.21942848
13TRIB32.21515716
14MAP3K42.18792622
15CAMKK12.03812177
16MAP3K21.91876671
17PHKG11.67044383
18PHKG21.67044383
19RIPK11.64565521
20MAP2K41.62662874
21LATS21.52190670
22SIK31.50982430
23NTRK21.50600988
24KSR11.50509834
25BMPR1B1.44136737
26RIPK41.43116798
27CDK51.41778906
28PKN21.38516011
29ACVR1B1.37307588
30SIK21.36246751
31RET1.33057334
32MAP2K71.31049084
33TYRO31.29656193
34TAOK11.29365811
35PAK31.25361506
36BCR1.23098679
37TESK11.22338279
38SCYL21.20688421
39STK381.12862783
40DAPK11.12011115
41PDGFRA1.09113905
42GRK51.06345909
43CAMKK21.05096726
44FGFR21.03188663
45PLK21.00512207
46PRKCH0.99375989
47CAMK2D0.98796782
48LMTK20.94994304
49STK110.92088526
50MAP3K10.91663789
51ALK0.88849065
52STK390.88169387
53EIF2AK10.86577737
54PRKCG0.86118210
55MAP3K120.86018365
56UHMK10.85564374
57PTK2B0.85406128
58DMPK0.84972567
59OXSR10.83217308
60BMPR20.81958555
61MAPK130.80794862
62CSNK1G30.79519178
63MAP3K130.78543344
64FER0.78324075
65PDPK10.77719495
66CAMK2G0.77691751
67TTN0.77077246
68CDK140.77060116
69WNK40.75676046
70MARK20.75433212
71DDR20.74340816
72CDK150.73315638
73MYLK0.73233059
74PTK20.72816776
75ARAF0.71828852
76CAMK2A0.71540674
77ROCK20.71483570
78MAP2K10.71288657
79CDK180.70430006
80BMX0.70244608
81PDK10.66972148
82CSNK1G20.66757844
83PKN10.65423344
84CCNB10.64623168
85PRKCZ0.64568658
86CDC42BPA0.62280853
87DAPK30.62010746
88CDK11A0.60739035
89CSNK1G10.60563615
90CSNK1A1L0.60062766
91SGK10.59139436
92CAMK1G0.59043018
93PRKG20.58553472
94PTK60.57856891
95SGK30.57285095
96SGK2230.56961938
97SGK4940.56961938
98RPS6KA20.56904141
99MOS0.56614258
100WNK30.56564700
101PINK10.55035322
102FES0.54397133
103NEK10.53726927
104EIF2AK30.53104382
105FYN0.51829893
106CAMK2B0.51577886
107IRAK30.51300054
108MAP3K70.50814234
109ERBB40.50522957
110MAPK120.50460492
111EPHB20.50039538
112CAMK10.49580276
113FGFR30.49459551
114PRKCE0.49031866
115HIPK20.48801705
116ERBB30.48601896
117LIMK10.47891842
118IRAK20.46944216
119PRKCI0.46654045
120AKT30.45849359
121ROCK10.44606534
122FRK0.43724445
123RPS6KA30.43346827
124TRPM70.43297074
125ICK0.41932115
126SGK20.41525599
127RAF10.40116755
128PDGFRB0.39886346
129FGR0.39233151
130GRK10.39119098
131MST1R0.39091328
132TNIK0.38186842
133PRPF4B0.38170998
134BRSK10.37822783
135OBSCN0.37612621
136MAPKAPK50.37212611
137DYRK1A0.36951493
138WNK10.36512898
139PAK40.35920524

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.01657216
2Synaptic vesicle cycle_Homo sapiens_hsa047212.71731268
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26157497
4Long-term potentiation_Homo sapiens_hsa047202.04475246
5Nicotine addiction_Homo sapiens_hsa050332.03499335
6Circadian entrainment_Homo sapiens_hsa047132.01505914
7Olfactory transduction_Homo sapiens_hsa047402.00153802
8GABAergic synapse_Homo sapiens_hsa047271.94542646
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.90278279
10Insulin secretion_Homo sapiens_hsa049111.85993983
11Glutamatergic synapse_Homo sapiens_hsa047241.80333937
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80020150
13Amphetamine addiction_Homo sapiens_hsa050311.74727715
14Morphine addiction_Homo sapiens_hsa050321.70991397
15Dopaminergic synapse_Homo sapiens_hsa047281.70691917
16Gastric acid secretion_Homo sapiens_hsa049711.67508283
17Cholinergic synapse_Homo sapiens_hsa047251.65095495
18Salivary secretion_Homo sapiens_hsa049701.64717168
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60939352
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59117080
21Nitrogen metabolism_Homo sapiens_hsa009101.57287983
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54951975
23Type II diabetes mellitus_Homo sapiens_hsa049301.49671603
24Renin secretion_Homo sapiens_hsa049241.43956763
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42326026
26Oxytocin signaling pathway_Homo sapiens_hsa049211.41612725
27Sulfur metabolism_Homo sapiens_hsa009201.37600579
28Cocaine addiction_Homo sapiens_hsa050301.35669513
29GnRH signaling pathway_Homo sapiens_hsa049121.30135502
30Glioma_Homo sapiens_hsa052141.29839798
31Gap junction_Homo sapiens_hsa045401.26859915
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25564193
33Long-term depression_Homo sapiens_hsa047301.23844838
34Collecting duct acid secretion_Homo sapiens_hsa049661.22675866
35Estrogen signaling pathway_Homo sapiens_hsa049151.20720804
36Protein export_Homo sapiens_hsa030601.17777237
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16239976
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13895820
39Axon guidance_Homo sapiens_hsa043601.09874051
40Dilated cardiomyopathy_Homo sapiens_hsa054141.07943304
41Taste transduction_Homo sapiens_hsa047421.06320774
42Serotonergic synapse_Homo sapiens_hsa047261.05564136
43Calcium signaling pathway_Homo sapiens_hsa040201.04600435
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03514416
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01524167
46cAMP signaling pathway_Homo sapiens_hsa040240.99325722
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98502385
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97842182
49Dorso-ventral axis formation_Homo sapiens_hsa043200.97796058
50Vibrio cholerae infection_Homo sapiens_hsa051100.95323648
51ErbB signaling pathway_Homo sapiens_hsa040120.94405200
52Circadian rhythm_Homo sapiens_hsa047100.93697762
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92361904
54Melanogenesis_Homo sapiens_hsa049160.92013610
55Mineral absorption_Homo sapiens_hsa049780.91229267
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90350019
57Bile secretion_Homo sapiens_hsa049760.90149987
58VEGF signaling pathway_Homo sapiens_hsa043700.89031940
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87595447
60mTOR signaling pathway_Homo sapiens_hsa041500.86579689
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.84328847
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.83659020
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.81857085
64Sphingolipid metabolism_Homo sapiens_hsa006000.81715842
65Thyroid hormone synthesis_Homo sapiens_hsa049180.78878254
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78536884
67Renal cell carcinoma_Homo sapiens_hsa052110.75042136
68Pancreatic secretion_Homo sapiens_hsa049720.74181449
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73977985
70Cardiac muscle contraction_Homo sapiens_hsa042600.73441162
71Endometrial cancer_Homo sapiens_hsa052130.72205535
72Insulin signaling pathway_Homo sapiens_hsa049100.70422894
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69864194
74Glucagon signaling pathway_Homo sapiens_hsa049220.67888875
75Prion diseases_Homo sapiens_hsa050200.67206063
76Folate biosynthesis_Homo sapiens_hsa007900.64804707
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64714412
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63735116
79Choline metabolism in cancer_Homo sapiens_hsa052310.63418452
80Endocytosis_Homo sapiens_hsa041440.62430432
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61964955
82MAPK signaling pathway_Homo sapiens_hsa040100.59968072
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.59875490
84Butanoate metabolism_Homo sapiens_hsa006500.59713949
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58661202
86Amoebiasis_Homo sapiens_hsa051460.58081273
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57943093
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57913807
89Inositol phosphate metabolism_Homo sapiens_hsa005620.56779857
90Rap1 signaling pathway_Homo sapiens_hsa040150.56729773
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56706211
92Phototransduction_Homo sapiens_hsa047440.56361149
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56241649
94Arginine biosynthesis_Homo sapiens_hsa002200.55477057
95Alzheimers disease_Homo sapiens_hsa050100.55442053
96Insulin resistance_Homo sapiens_hsa049310.54833316
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53173558
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52694746
99Focal adhesion_Homo sapiens_hsa045100.52499399
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.52228800
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.51277702
102Non-small cell lung cancer_Homo sapiens_hsa052230.50200832
103Ras signaling pathway_Homo sapiens_hsa040140.49504433
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49500070
105Lysosome_Homo sapiens_hsa041420.47708719
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47415299
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.46682281
108Type I diabetes mellitus_Homo sapiens_hsa049400.46516015
109Prolactin signaling pathway_Homo sapiens_hsa049170.46293496
110beta-Alanine metabolism_Homo sapiens_hsa004100.45936043
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45072044
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44662729
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44279607
114Arginine and proline metabolism_Homo sapiens_hsa003300.43263158
115Steroid biosynthesis_Homo sapiens_hsa001000.42656063
116Oxidative phosphorylation_Homo sapiens_hsa001900.42655500
117Fatty acid metabolism_Homo sapiens_hsa012120.42012505
118AMPK signaling pathway_Homo sapiens_hsa041520.41419372
119Tight junction_Homo sapiens_hsa045300.41285432
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40710717
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40630887
122Proteoglycans in cancer_Homo sapiens_hsa052050.40516038
123Fatty acid elongation_Homo sapiens_hsa000620.38708246
124Oocyte meiosis_Homo sapiens_hsa041140.38670783
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37956083
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37469304
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36797949
128Fatty acid biosynthesis_Homo sapiens_hsa000610.36688308
129Propanoate metabolism_Homo sapiens_hsa006400.35709532

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