

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 5.76980641 |
| 2 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.36021195 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.26962583 |
| 4 | vocalization behavior (GO:0071625) | 5.18286941 |
| 5 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.17131164 |
| 6 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.96851887 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.93122561 |
| 8 | synaptic vesicle maturation (GO:0016188) | 4.80179770 |
| 9 | synaptic vesicle exocytosis (GO:0016079) | 4.71413613 |
| 10 | glutamate receptor signaling pathway (GO:0007215) | 4.71290829 |
| 11 | neuronal action potential propagation (GO:0019227) | 4.66183718 |
| 12 | neuromuscular process controlling posture (GO:0050884) | 4.57183724 |
| 13 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.52185431 |
| 14 | synaptic transmission, glutamatergic (GO:0035249) | 4.40412330 |
| 15 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.37608534 |
| 16 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.35800338 |
| 17 | synaptic vesicle endocytosis (GO:0048488) | 4.33798030 |
| 18 | gamma-aminobutyric acid transport (GO:0015812) | 4.31598269 |
| 19 | cerebellar granule cell differentiation (GO:0021707) | 4.28906872 |
| 20 | neuromuscular process controlling balance (GO:0050885) | 4.21342220 |
| 21 | positive regulation of synapse maturation (GO:0090129) | 4.17707398 |
| 22 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.11013699 |
| 23 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.10830525 |
| 24 | glutamate secretion (GO:0014047) | 4.10583516 |
| 25 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.10299127 |
| 26 | protein localization to synapse (GO:0035418) | 4.10225536 |
| 27 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 4.08292832 |
| 28 | exploration behavior (GO:0035640) | 4.05752776 |
| 29 | neuron-neuron synaptic transmission (GO:0007270) | 4.04168998 |
| 30 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.02472896 |
| 31 | cerebellar Purkinje cell differentiation (GO:0021702) | 4.00929218 |
| 32 | potassium ion homeostasis (GO:0055075) | 4.00407613 |
| 33 | dendritic spine morphogenesis (GO:0060997) | 3.98314413 |
| 34 | long-term memory (GO:0007616) | 3.96854060 |
| 35 | neurotransmitter secretion (GO:0007269) | 3.95940205 |
| 36 | cellular potassium ion homeostasis (GO:0030007) | 3.94675246 |
| 37 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.93994289 |
| 38 | potassium ion import (GO:0010107) | 3.92310612 |
| 39 | response to pheromone (GO:0019236) | 3.89990276 |
| 40 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.85759073 |
| 41 | chemosensory behavior (GO:0007635) | 3.73246803 |
| 42 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.73058892 |
| 43 | transmission of nerve impulse (GO:0019226) | 3.72425219 |
| 44 | regulation of postsynaptic membrane potential (GO:0060078) | 3.71451017 |
| 45 | detection of calcium ion (GO:0005513) | 3.67982640 |
| 46 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.66059738 |
| 47 | L-amino acid import (GO:0043092) | 3.65200748 |
| 48 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.64827106 |
| 49 | regulation of vesicle fusion (GO:0031338) | 3.63447450 |
| 50 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.63235432 |
| 51 | regulation of synaptic vesicle transport (GO:1902803) | 3.61632805 |
| 52 | sodium ion export (GO:0071436) | 3.61608821 |
| 53 | layer formation in cerebral cortex (GO:0021819) | 3.60326211 |
| 54 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.59195380 |
| 55 | neuron cell-cell adhesion (GO:0007158) | 3.56275916 |
| 56 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.55901153 |
| 57 | neuromuscular process (GO:0050905) | 3.51398146 |
| 58 | proline biosynthetic process (GO:0006561) | 3.51069353 |
| 59 | regulation of synapse structural plasticity (GO:0051823) | 3.50984961 |
| 60 | postsynaptic membrane organization (GO:0001941) | 3.49468673 |
| 61 | positive regulation of neurotransmitter transport (GO:0051590) | 3.48832536 |
| 62 | positive regulation of membrane potential (GO:0045838) | 3.45994461 |
| 63 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.45970790 |
| 64 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.44479074 |
| 65 | cell migration in hindbrain (GO:0021535) | 3.40963954 |
| 66 | auditory behavior (GO:0031223) | 3.39614538 |
| 67 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.37990772 |
| 68 | positive regulation of dendritic spine development (GO:0060999) | 3.35975263 |
| 69 | regulation of synaptic plasticity (GO:0048167) | 3.34872908 |
| 70 | glycine transport (GO:0015816) | 3.32834442 |
| 71 | signal release (GO:0023061) | 3.27662557 |
| 72 | regulation of respiratory system process (GO:0044065) | 3.26171126 |
| 73 | signal complex assembly (GO:0007172) | 3.23680772 |
| 74 | cell differentiation in hindbrain (GO:0021533) | 3.22170898 |
| 75 | regulation of synapse maturation (GO:0090128) | 3.21898362 |
| 76 | presynaptic membrane organization (GO:0097090) | 3.21586116 |
| 77 | axon ensheathment in central nervous system (GO:0032291) | 3.21142434 |
| 78 | central nervous system myelination (GO:0022010) | 3.21142434 |
| 79 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.19708939 |
| 80 | synaptic vesicle transport (GO:0048489) | 3.19055833 |
| 81 | establishment of synaptic vesicle localization (GO:0097480) | 3.19055833 |
| 82 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.17912773 |
| 83 | membrane depolarization (GO:0051899) | 3.17111612 |
| 84 | membrane depolarization during action potential (GO:0086010) | 3.15796976 |
| 85 | neurotransmitter transport (GO:0006836) | 3.15462990 |
| 86 | synaptic transmission (GO:0007268) | 3.13827224 |
| 87 | dendritic spine organization (GO:0097061) | 3.12801961 |
| 88 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.12354612 |
| 89 | presynaptic membrane assembly (GO:0097105) | 3.11834931 |
| 90 | dendrite morphogenesis (GO:0048813) | 3.09850921 |
| 91 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.09462110 |
| 92 | amino acid import (GO:0043090) | 3.09235950 |
| 93 | regulation of neurotransmitter secretion (GO:0046928) | 3.07777080 |
| 94 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 3.07480178 |
| 95 | prepulse inhibition (GO:0060134) | 3.07163803 |
| 96 | regulation of ARF protein signal transduction (GO:0032012) | 3.05834401 |
| 97 | righting reflex (GO:0060013) | 3.04452942 |
| 98 | adult walking behavior (GO:0007628) | 3.04022750 |
| 99 | long term synaptic depression (GO:0060292) | 3.02456674 |
| 100 | regulation of synaptic transmission (GO:0050804) | 3.01695187 |
| 101 | axonal fasciculation (GO:0007413) | 3.01248846 |
| 102 | learning (GO:0007612) | 3.00645642 |
| 103 | membrane hyperpolarization (GO:0060081) | 3.00591719 |
| 104 | negative regulation of protein oligomerization (GO:0032460) | 2.97492841 |
| 105 | neuron recognition (GO:0008038) | 2.96615220 |
| 106 | negative regulation of dendrite development (GO:2000171) | 2.95863305 |
| 107 | neurotransmitter uptake (GO:0001504) | 2.94324223 |
| 108 | cerebellar Purkinje cell layer development (GO:0021680) | 2.93820386 |
| 109 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.93648245 |
| 110 | neuronal ion channel clustering (GO:0045161) | 2.92871988 |
| 111 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.92260850 |
| 112 | insulin secretion (GO:0030073) | 2.91706649 |
| 113 | regulation of neurotransmitter levels (GO:0001505) | 2.91143308 |
| 114 | response to auditory stimulus (GO:0010996) | 2.90926758 |
| 115 | long-term synaptic potentiation (GO:0060291) | 2.90873933 |
| 116 | regulation of exocytosis (GO:0017157) | 2.90658320 |
| 117 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.90092150 |
| 118 | regulation of respiratory gaseous exchange (GO:0043576) | 2.86897281 |
| 119 | regulation of neurotransmitter transport (GO:0051588) | 2.86774635 |
| 120 | regulation of dendritic spine development (GO:0060998) | 2.85528171 |
| 121 | cell communication by electrical coupling (GO:0010644) | 2.85242824 |
| 122 | mating behavior (GO:0007617) | 2.83054528 |
| 123 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.82193444 |
| 124 | behavioral defense response (GO:0002209) | 2.81354677 |
| 125 | behavioral fear response (GO:0001662) | 2.81354677 |
| 126 | mechanosensory behavior (GO:0007638) | 2.80812790 |
| 127 | proline transport (GO:0015824) | 2.80552038 |
| 128 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.79469052 |
| 129 | cellular sodium ion homeostasis (GO:0006883) | 2.79424571 |
| 130 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.76841361 |
| 131 | activation of protein kinase A activity (GO:0034199) | 2.76552672 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.05708465 |
| 2 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 3.04702687 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.80311582 |
| 4 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.79943253 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.75636164 |
| 6 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.69481417 |
| 7 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.69162333 |
| 8 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.67247961 |
| 9 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.64630890 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.59430509 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.59430509 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.52793483 |
| 13 | * DROSHA_22980978_ChIP-Seq_HELA_Human | 2.52409896 |
| 14 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.35266534 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.29570375 |
| 16 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.28205598 |
| 17 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.27657190 |
| 18 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.25547505 |
| 19 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.22387671 |
| 20 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.20955687 |
| 21 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 2.19353523 |
| 22 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.18255531 |
| 23 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.18215957 |
| 24 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.17507468 |
| 25 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.16759840 |
| 26 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.11594132 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.02295369 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.95011351 |
| 29 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.85069531 |
| 30 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.81909355 |
| 31 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.76313499 |
| 32 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.66807451 |
| 33 | KDM2B_26808549_Chip-Seq_K562_Human | 1.65566175 |
| 34 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.65157154 |
| 35 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.63098164 |
| 36 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.61940951 |
| 37 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.57336459 |
| 38 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.57002647 |
| 39 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.54254238 |
| 40 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.50752999 |
| 41 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.49937480 |
| 42 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.48622060 |
| 43 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.47697137 |
| 44 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.38395919 |
| 45 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.33732452 |
| 46 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.31382133 |
| 47 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.27996113 |
| 48 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.27024622 |
| 49 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.26605451 |
| 50 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.26416790 |
| 51 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.26267840 |
| 52 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.25452940 |
| 53 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.24298184 |
| 54 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.21435565 |
| 55 | AR_19668381_ChIP-Seq_PC3_Human | 1.20447890 |
| 56 | * TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.20150462 |
| 57 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.19468807 |
| 58 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.18605042 |
| 59 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.18206032 |
| 60 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.17908615 |
| 61 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.17408879 |
| 62 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.17182106 |
| 63 | P300_19829295_ChIP-Seq_ESCs_Human | 1.15734255 |
| 64 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.13289746 |
| 65 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.12491893 |
| 66 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.11328285 |
| 67 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.10660193 |
| 68 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.09482250 |
| 69 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.09414354 |
| 70 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.09338742 |
| 71 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.09214502 |
| 72 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.08984007 |
| 73 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.08306181 |
| 74 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07358287 |
| 75 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.05969563 |
| 76 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.05845310 |
| 77 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.05833202 |
| 78 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.04259403 |
| 79 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.04033835 |
| 80 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.03620820 |
| 81 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.02238879 |
| 82 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.02118001 |
| 83 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.00429869 |
| 84 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99739610 |
| 85 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.98307304 |
| 86 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.97703976 |
| 87 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.97703976 |
| 88 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.97703976 |
| 89 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.97627666 |
| 90 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.97292574 |
| 91 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.96932148 |
| 92 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.95201082 |
| 93 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.94561254 |
| 94 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93680224 |
| 95 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.93672118 |
| 96 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.93084312 |
| 97 | * STAT3_23295773_ChIP-Seq_U87_Human | 0.92051562 |
| 98 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.91172055 |
| 99 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.90984825 |
| 100 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.90967735 |
| 101 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.90585708 |
| 102 | * MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.90394511 |
| 103 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.90091397 |
| 104 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.89279284 |
| 105 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.89111439 |
| 106 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.88890056 |
| 107 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.88609419 |
| 108 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.88329294 |
| 109 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88157140 |
| 110 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.87128340 |
| 111 | * POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.85126997 |
| 112 | * TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85126997 |
| 113 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.85014796 |
| 114 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.84718868 |
| 115 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.84604886 |
| 116 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.84405936 |
| 117 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.84404909 |
| 118 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.84282414 |
| 119 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.83743345 |
| 120 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.83587763 |
| 121 | * TCF4_23295773_ChIP-Seq_U87_Human | 0.82720999 |
| 122 | * RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.82503334 |
| 123 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.82365435 |
| 124 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.82323045 |
| 125 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.81714157 |
| 126 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.81714157 |
| 127 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.81572027 |
| 128 | KDM2B_26808549_Chip-Seq_REH_Human | 0.81387127 |
| 129 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.81144086 |
| 130 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.80799470 |
| 131 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.80621301 |
| 132 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.80484429 |
| 133 | * KLF4_19829295_ChIP-Seq_ESCs_Human | 0.79997184 |
| 134 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.79767876 |
| 135 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.79412418 |
| 136 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.77812060 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.46718561 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 4.01142862 |
| 3 | MP0009046_muscle_twitch | 3.91123986 |
| 4 | MP0003880_abnormal_central_pattern | 3.72740735 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.28951006 |
| 6 | MP0009745_abnormal_behavioral_response | 3.22381384 |
| 7 | MP0002064_seizures | 3.09427308 |
| 8 | MP0002572_abnormal_emotion/affect_behav | 2.93323640 |
| 9 | MP0004270_analgesia | 2.86634573 |
| 10 | MP0002822_catalepsy | 2.80431669 |
| 11 | MP0002272_abnormal_nervous_system | 2.71771252 |
| 12 | MP0005423_abnormal_somatic_nervous | 2.54014826 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.39108379 |
| 14 | MP0001486_abnormal_startle_reflex | 2.36423914 |
| 15 | MP0008569_lethality_at_weaning | 2.34046457 |
| 16 | MP0005171_absent_coat_pigmentation | 2.25579088 |
| 17 | MP0003123_paternal_imprinting | 2.21941460 |
| 18 | MP0002734_abnormal_mechanical_nocicepti | 2.11310282 |
| 19 | MP0002067_abnormal_sensory_capabilities | 2.03035027 |
| 20 | MP0001440_abnormal_grooming_behavior | 1.99981713 |
| 21 | MP0002184_abnormal_innervation | 1.99212339 |
| 22 | MP0001501_abnormal_sleep_pattern | 1.97449576 |
| 23 | MP0002733_abnormal_thermal_nociception | 1.96531902 |
| 24 | MP0001970_abnormal_pain_threshold | 1.92681544 |
| 25 | MP0004233_abnormal_muscle_weight | 1.89472654 |
| 26 | MP0003283_abnormal_digestive_organ | 1.86099656 |
| 27 | MP0004145_abnormal_muscle_electrophysio | 1.78319386 |
| 28 | MP0002735_abnormal_chemical_nociception | 1.77866666 |
| 29 | MP0004142_abnormal_muscle_tone | 1.77088978 |
| 30 | MP0000778_abnormal_nervous_system | 1.73619856 |
| 31 | MP0000955_abnormal_spinal_cord | 1.72549443 |
| 32 | MP0002736_abnormal_nociception_after | 1.71839241 |
| 33 | MP0004924_abnormal_behavior | 1.70567821 |
| 34 | MP0005386_behavior/neurological_phenoty | 1.70567821 |
| 35 | MP0004811_abnormal_neuron_physiology | 1.62426150 |
| 36 | MP0005645_abnormal_hypothalamus_physiol | 1.61038501 |
| 37 | MP0003879_abnormal_hair_cell | 1.56304304 |
| 38 | MP0002557_abnormal_social/conspecific_i | 1.54467230 |
| 39 | MP0004885_abnormal_endolymph | 1.51577063 |
| 40 | MP0002066_abnormal_motor_capabilities/c | 1.50603895 |
| 41 | MP0002638_abnormal_pupillary_reflex | 1.44783188 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.42895135 |
| 43 | MP0003633_abnormal_nervous_system | 1.40936823 |
| 44 | MP0006072_abnormal_retinal_apoptosis | 1.37176911 |
| 45 | MP0001502_abnormal_circadian_rhythm | 1.30493592 |
| 46 | MP0002909_abnormal_adrenal_gland | 1.29771114 |
| 47 | MP0005646_abnormal_pituitary_gland | 1.27202295 |
| 48 | MP0003690_abnormal_glial_cell | 1.26439795 |
| 49 | MP0000920_abnormal_myelination | 1.25202607 |
| 50 | MP0003121_genomic_imprinting | 1.23404356 |
| 51 | MP0002152_abnormal_brain_morphology | 1.20638952 |
| 52 | MP0003329_amyloid_beta_deposits | 1.18142820 |
| 53 | MP0001177_atelectasis | 1.17817315 |
| 54 | MP0003631_nervous_system_phenotype | 1.16396817 |
| 55 | MP0009780_abnormal_chondrocyte_physiolo | 1.16366706 |
| 56 | MP0001485_abnormal_pinna_reflex | 1.14457783 |
| 57 | MP0003137_abnormal_impulse_conducting | 1.13273720 |
| 58 | MP0001905_abnormal_dopamine_level | 1.12169617 |
| 59 | MP0004858_abnormal_nervous_system | 1.11150088 |
| 60 | MP0000751_myopathy | 1.07131466 |
| 61 | MP0003045_fibrosis | 1.06628128 |
| 62 | MP0002249_abnormal_larynx_morphology | 1.05900667 |
| 63 | MP0002009_preneoplasia | 1.05348592 |
| 64 | MP0000569_abnormal_digit_pigmentation | 1.04387672 |
| 65 | MP0004147_increased_porphyrin_level | 1.03993499 |
| 66 | MP0010234_abnormal_vibrissa_follicle | 1.00603513 |
| 67 | MP0010386_abnormal_urinary_bladder | 1.00059743 |
| 68 | MP0001984_abnormal_olfaction | 0.98699242 |
| 69 | MP0003787_abnormal_imprinting | 0.98230832 |
| 70 | MP0001963_abnormal_hearing_physiology | 0.96880252 |
| 71 | MP0005535_abnormal_body_temperature | 0.94576951 |
| 72 | MP0004742_abnormal_vestibular_system | 0.93292048 |
| 73 | MP0002653_abnormal_ependyma_morphology | 0.92920840 |
| 74 | MP0008874_decreased_physiological_sensi | 0.89067390 |
| 75 | MP0008995_early_reproductive_senescence | 0.88994239 |
| 76 | MP0005551_abnormal_eye_electrophysiolog | 0.88517285 |
| 77 | MP0010030_abnormal_orbit_morphology | 0.88296353 |
| 78 | MP0004133_heterotaxia | 0.88081225 |
| 79 | MP0001986_abnormal_taste_sensitivity | 0.87838347 |
| 80 | MP0003119_abnormal_digestive_system | 0.86558920 |
| 81 | MP0004043_abnormal_pH_regulation | 0.86539910 |
| 82 | MP0008872_abnormal_physiological_respon | 0.86470853 |
| 83 | MP0002752_abnormal_somatic_nervous | 0.84477428 |
| 84 | MP0002229_neurodegeneration | 0.84101618 |
| 85 | MP0002837_dystrophic_cardiac_calcinosis | 0.83992441 |
| 86 | MP0002090_abnormal_vision | 0.83409326 |
| 87 | MP0003632_abnormal_nervous_system | 0.82640201 |
| 88 | MP0003075_altered_response_to | 0.81492896 |
| 89 | MP0009278_abnormal_bone_marrow | 0.80131722 |
| 90 | MP0003890_abnormal_embryonic-extraembry | 0.79431025 |
| 91 | MP0002069_abnormal_eating/drinking_beha | 0.79236224 |
| 92 | MP0003172_abnormal_lysosome_physiology | 0.79234995 |
| 93 | MP0003195_calcinosis | 0.78806113 |
| 94 | MP0003634_abnormal_glial_cell | 0.78245609 |
| 95 | MP0002876_abnormal_thyroid_physiology | 0.77301398 |
| 96 | MP0003861_abnormal_nervous_system | 0.76319208 |
| 97 | MP0001944_abnormal_pancreas_morphology | 0.76056162 |
| 98 | MP0001188_hyperpigmentation | 0.73988880 |
| 99 | MP0005253_abnormal_eye_physiology | 0.72718613 |
| 100 | MP0008877_abnormal_DNA_methylation | 0.72497135 |
| 101 | MP0000639_abnormal_adrenal_gland | 0.72375866 |
| 102 | MP0006276_abnormal_autonomic_nervous | 0.71848517 |
| 103 | MP0000631_abnormal_neuroendocrine_gland | 0.71279542 |
| 104 | MP0010769_abnormal_survival | 0.70450750 |
| 105 | MP0002928_abnormal_bile_duct | 0.69821356 |
| 106 | MP0010768_mortality/aging | 0.69572413 |
| 107 | MP0002693_abnormal_pancreas_physiology | 0.69408651 |
| 108 | MP0000026_abnormal_inner_ear | 0.68829892 |
| 109 | MP0005394_taste/olfaction_phenotype | 0.68788359 |
| 110 | MP0005499_abnormal_olfactory_system | 0.68788359 |
| 111 | MP0001529_abnormal_vocalization | 0.68216457 |
| 112 | MP0001943_abnormal_respiration | 0.67957208 |
| 113 | MP0004215_abnormal_myocardial_fiber | 0.67454075 |
| 114 | MP0002089_abnormal_postnatal_growth/wei | 0.67155298 |
| 115 | MP0000013_abnormal_adipose_tissue | 0.65705781 |
| 116 | MP0000579_abnormal_nail_morphology | 0.64954748 |
| 117 | MP0005623_abnormal_meninges_morphology | 0.64801671 |
| 118 | MP0010770_preweaning_lethality | 0.64314791 |
| 119 | MP0002082_postnatal_lethality | 0.64314791 |
| 120 | MP0000015_abnormal_ear_pigmentation | 0.64279847 |
| 121 | MP0008057_abnormal_DNA_replication | 0.63921165 |
| 122 | MP0005167_abnormal_blood-brain_barrier | 0.62868098 |
| 123 | MP0001765_abnormal_ion_homeostasis | 0.61092033 |
| 124 | MP0002078_abnormal_glucose_homeostasis | 0.60327120 |
| 125 | MP0003122_maternal_imprinting | 0.59014392 |
| 126 | MP0004085_abnormal_heartbeat | 0.57812466 |
| 127 | MP0001348_abnormal_lacrimal_gland | 0.56407605 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.39790832 |
| 2 | Myokymia (HP:0002411) | 6.33477931 |
| 3 | Annular pancreas (HP:0001734) | 5.24742658 |
| 4 | Focal seizures (HP:0007359) | 4.88721675 |
| 5 | Hypoglycemic seizures (HP:0002173) | 4.83762963 |
| 6 | Progressive cerebellar ataxia (HP:0002073) | 4.79365267 |
| 7 | Action tremor (HP:0002345) | 4.71753312 |
| 8 | Visual hallucinations (HP:0002367) | 4.65920050 |
| 9 | Atonic seizures (HP:0010819) | 4.57398732 |
| 10 | Febrile seizures (HP:0002373) | 4.52018070 |
| 11 | Hyperinsulinemic hypoglycemia (HP:0000825) | 4.44399743 |
| 12 | Epileptic encephalopathy (HP:0200134) | 4.24604665 |
| 13 | Gaze-evoked nystagmus (HP:0000640) | 3.83597110 |
| 14 | Absence seizures (HP:0002121) | 3.80546814 |
| 15 | Dysdiadochokinesis (HP:0002075) | 3.79266219 |
| 16 | Hypoglycemic coma (HP:0001325) | 3.73643599 |
| 17 | Broad-based gait (HP:0002136) | 3.40924671 |
| 18 | Abnormality of the lower motor neuron (HP:0002366) | 3.38775983 |
| 19 | Dialeptic seizures (HP:0011146) | 3.37414028 |
| 20 | Limb dystonia (HP:0002451) | 3.35820369 |
| 21 | Papilledema (HP:0001085) | 3.35717724 |
| 22 | Dysmetria (HP:0001310) | 3.24607919 |
| 23 | Increased circulating renin level (HP:0000848) | 3.20082169 |
| 24 | Ketoacidosis (HP:0001993) | 3.11241511 |
| 25 | Impaired smooth pursuit (HP:0007772) | 3.10758053 |
| 26 | Spastic gait (HP:0002064) | 3.08297907 |
| 27 | Dysmetric saccades (HP:0000641) | 3.05406262 |
| 28 | Genetic anticipation (HP:0003743) | 3.03142866 |
| 29 | Intention tremor (HP:0002080) | 2.98780196 |
| 30 | Hemiplegia (HP:0002301) | 2.95296029 |
| 31 | Cerebral hypomyelination (HP:0006808) | 2.93572182 |
| 32 | Generalized tonic-clonic seizures (HP:0002069) | 2.92779952 |
| 33 | Symptomatic seizures (HP:0011145) | 2.92450738 |
| 34 | Scanning speech (HP:0002168) | 2.85750270 |
| 35 | Turricephaly (HP:0000262) | 2.84416407 |
| 36 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.80020409 |
| 37 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.80020409 |
| 38 | Poor eye contact (HP:0000817) | 2.78614745 |
| 39 | Alacrima (HP:0000522) | 2.68460883 |
| 40 | Fetal akinesia sequence (HP:0001989) | 2.66703970 |
| 41 | Concave nail (HP:0001598) | 2.66608794 |
| 42 | Hemiparesis (HP:0001269) | 2.66273233 |
| 43 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.64714312 |
| 44 | Tetraplegia (HP:0002445) | 2.61996981 |
| 45 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.60606074 |
| 46 | Impaired social interactions (HP:0000735) | 2.58550213 |
| 47 | Abnormal social behavior (HP:0012433) | 2.58550213 |
| 48 | Neurofibrillary tangles (HP:0002185) | 2.57126527 |
| 49 | Akinesia (HP:0002304) | 2.54070061 |
| 50 | Hypomagnesemia (HP:0002917) | 2.52209330 |
| 51 | Sleep apnea (HP:0010535) | 2.49766163 |
| 52 | Truncal ataxia (HP:0002078) | 2.49272671 |
| 53 | Status epilepticus (HP:0002133) | 2.47808020 |
| 54 | Bradykinesia (HP:0002067) | 2.47501526 |
| 55 | Hyperthyroidism (HP:0000836) | 2.39297782 |
| 56 | Abnormality of binocular vision (HP:0011514) | 2.37380527 |
| 57 | Diplopia (HP:0000651) | 2.37380527 |
| 58 | Rib fusion (HP:0000902) | 2.35109102 |
| 59 | Abnormality of the corticospinal tract (HP:0002492) | 2.33726177 |
| 60 | Large for gestational age (HP:0001520) | 2.32649505 |
| 61 | Narrow nasal bridge (HP:0000446) | 2.32278305 |
| 62 | Hyperglycemia (HP:0003074) | 2.32230070 |
| 63 | Anteriorly placed anus (HP:0001545) | 2.31776940 |
| 64 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.31434359 |
| 65 | Craniofacial dystonia (HP:0012179) | 2.30509451 |
| 66 | Hepatoblastoma (HP:0002884) | 2.30485527 |
| 67 | Clumsiness (HP:0002312) | 2.28895358 |
| 68 | Short chin (HP:0000331) | 2.27253913 |
| 69 | Obstructive sleep apnea (HP:0002870) | 2.26909641 |
| 70 | Depression (HP:0000716) | 2.25473785 |
| 71 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.25471881 |
| 72 | Coronal craniosynostosis (HP:0004440) | 2.20578208 |
| 73 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.19757690 |
| 74 | Polyphagia (HP:0002591) | 2.19263708 |
| 75 | Anxiety (HP:0000739) | 2.18078775 |
| 76 | Supranuclear gaze palsy (HP:0000605) | 2.16910042 |
| 77 | Clonus (HP:0002169) | 2.15335837 |
| 78 | Aqueductal stenosis (HP:0002410) | 2.14161829 |
| 79 | Ankle clonus (HP:0011448) | 2.13361464 |
| 80 | Postural instability (HP:0002172) | 2.12509300 |
| 81 | Amblyopia (HP:0000646) | 2.11193244 |
| 82 | Abnormality of the aortic arch (HP:0012303) | 2.09650616 |
| 83 | Late onset (HP:0003584) | 2.09335292 |
| 84 | Abnormal eating behavior (HP:0100738) | 2.08242192 |
| 85 | Decreased lacrimation (HP:0000633) | 2.06311566 |
| 86 | Abnormality of magnesium homeostasis (HP:0004921) | 2.05896537 |
| 87 | Delusions (HP:0000746) | 2.05026987 |
| 88 | Lower limb muscle weakness (HP:0007340) | 2.04456678 |
| 89 | Muscular hypotonia of the trunk (HP:0008936) | 2.01272436 |
| 90 | Facial hemangioma (HP:0000329) | 2.00442602 |
| 91 | Spastic tetraparesis (HP:0001285) | 1.97824722 |
| 92 | Stereotypic behavior (HP:0000733) | 1.94582887 |
| 93 | Cerebral inclusion bodies (HP:0100314) | 1.93339515 |
| 94 | Urinary urgency (HP:0000012) | 1.92721071 |
| 95 | Horizontal nystagmus (HP:0000666) | 1.92478673 |
| 96 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.92470454 |
| 97 | Rigidity (HP:0002063) | 1.92085711 |
| 98 | Epileptiform EEG discharges (HP:0011182) | 1.91785339 |
| 99 | CNS hypomyelination (HP:0003429) | 1.90854789 |
| 100 | Congenital hip dislocation (HP:0001374) | 1.89134787 |
| 101 | Ketosis (HP:0001946) | 1.89133818 |
| 102 | Pointed chin (HP:0000307) | 1.88541009 |
| 103 | Limb ataxia (HP:0002070) | 1.87002447 |
| 104 | Hyperventilation (HP:0002883) | 1.86910531 |
| 105 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.85654162 |
| 106 | Gait ataxia (HP:0002066) | 1.85565526 |
| 107 | Alopecia of scalp (HP:0002293) | 1.85183064 |
| 108 | Thickened helices (HP:0000391) | 1.84553276 |
| 109 | Mutism (HP:0002300) | 1.84279487 |
| 110 | Male infertility (HP:0003251) | 1.82880233 |
| 111 | Abnormality of the periventricular white matter (HP:0002518) | 1.82280788 |
| 112 | Choreoathetosis (HP:0001266) | 1.82254716 |
| 113 | Incomplete penetrance (HP:0003829) | 1.81821934 |
| 114 | Torticollis (HP:0000473) | 1.81595329 |
| 115 | EEG with generalized epileptiform discharges (HP:0011198) | 1.81420895 |
| 116 | Rectal fistula (HP:0100590) | 1.80928706 |
| 117 | Rectovaginal fistula (HP:0000143) | 1.80928706 |
| 118 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.80910009 |
| 119 | Ventricular fibrillation (HP:0001663) | 1.75434770 |
| 120 | Hamartoma (HP:0010566) | 1.73755720 |
| 121 | Excessive salivation (HP:0003781) | 1.73463126 |
| 122 | Drooling (HP:0002307) | 1.73463126 |
| 123 | Focal dystonia (HP:0004373) | 1.71902765 |
| 124 | Impaired vibratory sensation (HP:0002495) | 1.70402143 |
| 125 | Hypsarrhythmia (HP:0002521) | 1.70134364 |
| 126 | Intestinal fistula (HP:0100819) | 1.69027344 |
| 127 | Split foot (HP:0001839) | 1.68726661 |
| 128 | Postural tremor (HP:0002174) | 1.67902231 |
| 129 | Abnormality of the labia minora (HP:0012880) | 1.67065161 |
| 130 | Short humerus (HP:0005792) | 1.65532012 |
| 131 | Intestinal atresia (HP:0011100) | 1.65489122 |
| 132 | Orthostatic hypotension (HP:0001278) | 1.64069073 |
| 133 | Choroideremia (HP:0001139) | 1.62613206 |
| 134 | Specific learning disability (HP:0001328) | 1.62440775 |
| 135 | Abnormality of the astrocytes (HP:0100707) | 1.62279209 |
| 136 | Astrocytoma (HP:0009592) | 1.62279209 |
| 137 | Lower limb asymmetry (HP:0100559) | 1.61932006 |
| 138 | Hypercortisolism (HP:0001578) | 1.61766820 |
| 139 | Increased IgM level (HP:0003496) | 1.60663841 |
| 140 | Abnormality of saccadic eye movements (HP:0000570) | 1.60661464 |
| 141 | Generalized myoclonic seizures (HP:0002123) | 1.60412461 |
| 142 | Hypochromic microcytic anemia (HP:0004840) | 1.60159132 |
| 143 | Anophthalmia (HP:0000528) | 1.60144802 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 3.71543051 |
| 2 | DDR2 | 3.70194350 |
| 3 | NTRK3 | 3.67246522 |
| 4 | ICK | 3.30040595 |
| 5 | MAP3K9 | 3.03249939 |
| 6 | FRK | 2.66191810 |
| 7 | PINK1 | 2.61704510 |
| 8 | TYRO3 | 2.61665135 |
| 9 | MAP3K6 | 2.42500823 |
| 10 | PRPF4B | 2.42275952 |
| 11 | DAPK1 | 2.34737467 |
| 12 | FGFR2 | 2.30380003 |
| 13 | UHMK1 | 2.22660146 |
| 14 | MAPK15 | 2.03569460 |
| 15 | MAP3K4 | 2.01004844 |
| 16 | NTRK2 | 1.91725907 |
| 17 | PAK6 | 1.89086908 |
| 18 | DAPK2 | 1.88722385 |
| 19 | FGR | 1.80280525 |
| 20 | MINK1 | 1.79496756 |
| 21 | MARK1 | 1.73268059 |
| 22 | STK38 | 1.63084674 |
| 23 | PRKD2 | 1.59931994 |
| 24 | CAMKK1 | 1.52033520 |
| 25 | SIK2 | 1.47030398 |
| 26 | CAMKK2 | 1.45421036 |
| 27 | PRKD3 | 1.45326229 |
| 28 | RIPK1 | 1.35511778 |
| 29 | RIPK4 | 1.33763046 |
| 30 | BMX | 1.32971687 |
| 31 | MATK | 1.31697701 |
| 32 | MAP2K7 | 1.30409690 |
| 33 | CDK5 | 1.25106789 |
| 34 | NTRK1 | 1.20202726 |
| 35 | MAP3K11 | 1.19869991 |
| 36 | PHKG2 | 1.17998552 |
| 37 | PHKG1 | 1.17998552 |
| 38 | KSR2 | 1.16711366 |
| 39 | CDC42BPA | 1.16625785 |
| 40 | PAK3 | 1.12008112 |
| 41 | LATS2 | 1.07089899 |
| 42 | CAMK2B | 1.06150415 |
| 43 | PDGFRA | 1.05888279 |
| 44 | IRAK2 | 1.02463221 |
| 45 | AKT3 | 1.01540801 |
| 46 | CDK19 | 1.00314929 |
| 47 | KSR1 | 0.99010056 |
| 48 | CAMK2A | 0.98919124 |
| 49 | PRKCG | 0.97361115 |
| 50 | MAP2K4 | 0.96178002 |
| 51 | YES1 | 0.95186061 |
| 52 | LIMK1 | 0.95157036 |
| 53 | TAOK1 | 0.93561782 |
| 54 | PASK | 0.91899410 |
| 55 | SGK1 | 0.90678133 |
| 56 | RAF1 | 0.89055351 |
| 57 | MARK2 | 0.88886362 |
| 58 | CDK15 | 0.84954488 |
| 59 | CDK18 | 0.82746227 |
| 60 | TNIK | 0.81427898 |
| 61 | STK11 | 0.79965384 |
| 62 | ALK | 0.78189058 |
| 63 | TNK2 | 0.76573255 |
| 64 | CASK | 0.75276084 |
| 65 | CDK11A | 0.75227743 |
| 66 | WNK1 | 0.74935721 |
| 67 | DYRK1B | 0.74146462 |
| 68 | CAMK2G | 0.72065406 |
| 69 | TAOK2 | 0.71039828 |
| 70 | CDK14 | 0.70418186 |
| 71 | MAP3K13 | 0.68706885 |
| 72 | MAPK13 | 0.68674273 |
| 73 | CAMK1 | 0.68380801 |
| 74 | TESK1 | 0.68239523 |
| 75 | GRK5 | 0.68233005 |
| 76 | CSK | 0.67745417 |
| 77 | FES | 0.63412477 |
| 78 | ARAF | 0.63294674 |
| 79 | PKN1 | 0.62619606 |
| 80 | CAMK2D | 0.61425762 |
| 81 | PLK2 | 0.61048302 |
| 82 | PRKCH | 0.60852415 |
| 83 | ROCK2 | 0.58704854 |
| 84 | DMPK | 0.58683800 |
| 85 | SGK494 | 0.56998259 |
| 86 | SGK223 | 0.56998259 |
| 87 | CAMK1G | 0.56654903 |
| 88 | RPS6KA3 | 0.55767091 |
| 89 | MAPK10 | 0.55712250 |
| 90 | LMTK2 | 0.55403452 |
| 91 | MAP3K1 | 0.55167873 |
| 92 | HIPK2 | 0.55000601 |
| 93 | CAMK4 | 0.53092082 |
| 94 | PRKCZ | 0.53083478 |
| 95 | SGK3 | 0.52302746 |
| 96 | CSNK1G2 | 0.52299595 |
| 97 | MAP3K12 | 0.51274919 |
| 98 | PRKCE | 0.48942000 |
| 99 | SGK2 | 0.48879952 |
| 100 | PRKAA1 | 0.48687523 |
| 101 | RPS6KC1 | 0.48559215 |
| 102 | RPS6KL1 | 0.48559215 |
| 103 | OXSR1 | 0.46484825 |
| 104 | INSRR | 0.46400731 |
| 105 | MAP2K6 | 0.45868032 |
| 106 | NEK6 | 0.44801873 |
| 107 | DAPK3 | 0.44488174 |
| 108 | FGFR3 | 0.44126479 |
| 109 | MAPK12 | 0.44007318 |
| 110 | DYRK1A | 0.43592011 |
| 111 | PRKG1 | 0.42727654 |
| 112 | PDK1 | 0.41696494 |
| 113 | ROCK1 | 0.40394027 |
| 114 | PRKACA | 0.39734010 |
| 115 | PTK2B | 0.39229746 |
| 116 | PRKCA | 0.38389217 |
| 117 | BRSK1 | 0.37940894 |
| 118 | RPS6KB1 | 0.37081183 |
| 119 | PNCK | 0.36499589 |
| 120 | PDPK1 | 0.35765543 |
| 121 | RPS6KA6 | 0.34614297 |
| 122 | CCNB1 | 0.32299229 |
| 123 | FYN | 0.32048479 |
| 124 | BMPR2 | 0.31992567 |
| 125 | PTK2 | 0.31695968 |
| 126 | STK38L | 0.31346205 |
| 127 | MAP3K2 | 0.30751952 |
| 128 | PRKCB | 0.28970008 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.06736740 |
| 2 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.77716832 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.71210482 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 2.68323313 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.64615669 |
| 6 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.61733742 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.61250717 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.50419112 |
| 9 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.50323456 |
| 10 | Olfactory transduction_Homo sapiens_hsa04740 | 2.49550886 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.43978457 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.16919310 |
| 13 | Long-term depression_Homo sapiens_hsa04730 | 2.10409941 |
| 14 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.98193061 |
| 15 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.97648788 |
| 16 | Taste transduction_Homo sapiens_hsa04742 | 1.90328669 |
| 17 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.89700050 |
| 18 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.78934232 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.74588884 |
| 20 | Insulin secretion_Homo sapiens_hsa04911 | 1.70396631 |
| 21 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.67920335 |
| 22 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.63653134 |
| 23 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.58330352 |
| 24 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.58206340 |
| 25 | Gap junction_Homo sapiens_hsa04540 | 1.56335404 |
| 26 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.53009138 |
| 27 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.46605918 |
| 28 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.46157002 |
| 29 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.44906386 |
| 30 | Cocaine addiction_Homo sapiens_hsa05030 | 1.44493213 |
| 31 | Renin secretion_Homo sapiens_hsa04924 | 1.44377197 |
| 32 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.42082406 |
| 33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.37287562 |
| 34 | Circadian rhythm_Homo sapiens_hsa04710 | 1.34826633 |
| 35 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.29055832 |
| 36 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.28089288 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.26554761 |
| 38 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.26479077 |
| 39 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.23930076 |
| 40 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.18006140 |
| 41 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.16894468 |
| 42 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.13037051 |
| 43 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.08004448 |
| 44 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.05897569 |
| 45 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.03574095 |
| 46 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.02932849 |
| 47 | Axon guidance_Homo sapiens_hsa04360 | 0.99463667 |
| 48 | Melanogenesis_Homo sapiens_hsa04916 | 0.99297433 |
| 49 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.97497539 |
| 50 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.95471490 |
| 51 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.94204192 |
| 52 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.92401365 |
| 53 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.90624084 |
| 54 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.88612779 |
| 55 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.88608767 |
| 56 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.88176458 |
| 57 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.87394312 |
| 58 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.87146138 |
| 59 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.87079364 |
| 60 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.84708176 |
| 61 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.84509723 |
| 62 | Glioma_Homo sapiens_hsa05214 | 0.83562831 |
| 63 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.83338078 |
| 64 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.82919748 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.82560143 |
| 66 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.82321325 |
| 67 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.81183556 |
| 68 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.80150979 |
| 69 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.77324627 |
| 70 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.74922340 |
| 71 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.74784292 |
| 72 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.70306705 |
| 73 | Phototransduction_Homo sapiens_hsa04744 | 0.70248288 |
| 74 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.67228434 |
| 75 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.62841661 |
| 76 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.57766271 |
| 77 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.57336762 |
| 78 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.55104561 |
| 79 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.53570596 |
| 80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.53043031 |
| 81 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.52434734 |
| 82 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.51030517 |
| 83 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.50661787 |
| 84 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.49536595 |
| 85 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.49301197 |
| 86 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.49199490 |
| 87 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.48934054 |
| 88 | Endocytosis_Homo sapiens_hsa04144 | 0.48856836 |
| 89 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.47077787 |
| 90 | Mineral absorption_Homo sapiens_hsa04978 | 0.45053152 |
| 91 | Alzheimers disease_Homo sapiens_hsa05010 | 0.43589695 |
| 92 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.43321717 |
| 93 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.42663176 |
| 94 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.42168235 |
| 95 | Colorectal cancer_Homo sapiens_hsa05210 | 0.41541076 |
| 96 | Tight junction_Homo sapiens_hsa04530 | 0.41368009 |
| 97 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.40722073 |
| 98 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.39638593 |
| 99 | Bile secretion_Homo sapiens_hsa04976 | 0.39041059 |
| 100 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.38353953 |
| 101 | ABC transporters_Homo sapiens_hsa02010 | 0.38302819 |
| 102 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.36965383 |
| 103 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.36944424 |
| 104 | Endometrial cancer_Homo sapiens_hsa05213 | 0.36183504 |
| 105 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.34514262 |
| 106 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.34076211 |
| 107 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.33709821 |
| 108 | Alcoholism_Homo sapiens_hsa05034 | 0.32114625 |
| 109 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.31416627 |
| 110 | Adherens junction_Homo sapiens_hsa04520 | 0.30466489 |
| 111 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.29773909 |
| 112 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.29307267 |
| 113 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.29134340 |
| 114 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.29007886 |
| 115 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.28732722 |
| 116 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.28568369 |
| 117 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.28448454 |
| 118 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.28229358 |
| 119 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.27337548 |
| 120 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.26493307 |
| 121 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.25268208 |
| 122 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.24299117 |
| 123 | Prion diseases_Homo sapiens_hsa05020 | 0.19815325 |
| 124 | Histidine metabolism_Homo sapiens_hsa00340 | 0.18250424 |

