WT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular epithelial cell development (GO:0072310)9.64999020
2regulation of cardioblast differentiation (GO:0051890)9.31830804
3endocardial cushion development (GO:0003197)8.98940929
4* glomerulus development (GO:0032835)8.97688857
5parturition (GO:0007567)8.06910621
6regulation of gonadotropin secretion (GO:0032276)7.98140279
7seminiferous tubule development (GO:0072520)7.94676781
8mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)7.81523021
9response to follicle-stimulating hormone (GO:0032354)7.65622909
10negative regulation of macrophage differentiation (GO:0045650)7.41054225
11gonadal mesoderm development (GO:0007506)7.36194878
12embryonic foregut morphogenesis (GO:0048617)7.22481808
13cardiac right ventricle morphogenesis (GO:0003215)7.20078450
14cardiac muscle adaptation (GO:0014887)7.07461534
15cardiac muscle hypertrophy in response to stress (GO:0014898)7.07461534
16muscle hypertrophy in response to stress (GO:0003299)7.07461534
17* cellular response to gonadotropin stimulus (GO:0071371)7.03791398
18SMAD protein signal transduction (GO:0060395)6.63772970
19epithelial cell fate commitment (GO:0072148)6.44849783
20mesenchymal cell differentiation involved in renal system development (GO:2001012)6.36654434
21mesenchymal cell differentiation involved in kidney development (GO:0072161)6.36654434
22regulation of cardiac muscle cell contraction (GO:0086004)5.97640644
23atrial septum morphogenesis (GO:0060413)5.89484251
24regulation of chromatin binding (GO:0035561)5.46728295
25labyrinthine layer development (GO:0060711)5.34617554
26cell differentiation involved in metanephros development (GO:0072202)5.33152536
27cardiac muscle hypertrophy (GO:0003300)5.28834730
28* mesenchymal to epithelial transition (GO:0060231)5.26209600
29lymph vessel development (GO:0001945)5.12450591
30hemoglobin metabolic process (GO:0020027)5.09882963
31regulation of apoptotic process involved in morphogenesis (GO:1902337)5.06673499
32* response to gonadotropin (GO:0034698)5.06464059
33short-chain fatty acid metabolic process (GO:0046459)5.00005018
34* mesonephros development (GO:0001823)4.99257369
35striated muscle hypertrophy (GO:0014897)4.95992864
36endoderm formation (GO:0001706)4.88811615
37fusion of sperm to egg plasma membrane (GO:0007342)4.88658796
38embryonic skeletal joint morphogenesis (GO:0060272)4.72259999
39* metanephros development (GO:0001656)4.68034329
40urogenital system development (GO:0001655)4.67035683
41muscle hypertrophy (GO:0014896)4.63800372
42biotin metabolic process (GO:0006768)4.62530888
43cell proliferation involved in metanephros development (GO:0072203)4.60413609
44regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.58836186
45regulation of actin filament-based movement (GO:1903115)4.57838823
46embryonic digestive tract morphogenesis (GO:0048557)4.55310127
47face development (GO:0060324)4.52602913
48proximal/distal pattern formation (GO:0009954)4.52184580
49* kidney mesenchyme development (GO:0072074)4.49734271
50detection of temperature stimulus involved in sensory perception (GO:0050961)4.43747653
51detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.43747653
52protein prenylation (GO:0018342)4.37247906
53prenylation (GO:0097354)4.37247906
54pattern specification involved in kidney development (GO:0061004)4.34272100
55male sex determination (GO:0030238)4.25226572
56diterpenoid biosynthetic process (GO:0016102)4.24369671
57* positive regulation of male gonad development (GO:2000020)4.18882698
58* sex determination (GO:0007530)4.15291128
59cornea development in camera-type eye (GO:0061303)4.13650585
60outer ear morphogenesis (GO:0042473)4.10395319
61vitamin A metabolic process (GO:0006776)4.08519511
62* regulation of male gonad development (GO:2000018)4.05686509
63positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.95070904
64regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.94745541
65positive regulation of cardiac muscle cell proliferation (GO:0060045)3.93160479
66* negative regulation of metanephros development (GO:0072217)3.92326407
67cell proliferation involved in kidney development (GO:0072111)3.89922958
68gastrulation with mouth forming second (GO:0001702)3.89373432
69* metanephric mesenchyme development (GO:0072075)3.88048764
70ventricular septum development (GO:0003281)3.86253997
71* branching involved in ureteric bud morphogenesis (GO:0001658)3.85771693
72* cell differentiation involved in kidney development (GO:0061005)3.83155532
73paraxial mesoderm development (GO:0048339)3.81845688
74cell-cell junction maintenance (GO:0045217)3.77609815
75signal transduction involved in regulation of gene expression (GO:0023019)3.76222911
76respiratory tube development (GO:0030323)3.71021781
77positive regulation vascular endothelial growth factor production (GO:0010575)3.67357711
78striated muscle adaptation (GO:0014888)3.63248766
79positive regulation of cardiac muscle tissue growth (GO:0055023)3.62289159
80regulation of stem cell maintenance (GO:2000036)3.60793801
81cardiac muscle tissue development (GO:0048738)3.60093548
82protein-chromophore linkage (GO:0018298)3.59999689
83* regulation of mesonephros development (GO:0061217)3.55312281
84plasma membrane fusion (GO:0045026)3.53072371
85nephron tubule formation (GO:0072079)3.48233907
86regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.48016193
87short-term memory (GO:0007614)3.47759578
88* positive regulation of mesonephros development (GO:0061213)3.47718456
89ubiquinone biosynthetic process (GO:0006744)3.46880466
90smooth muscle tissue development (GO:0048745)3.45991159
91lung vasculature development (GO:0060426)3.43874685
92regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.41490714
93facial nerve structural organization (GO:0021612)3.41147552
94* mesonephric tubule development (GO:0072164)3.40455778
95mesenchyme morphogenesis (GO:0072132)3.39575776
96mesenchymal cell differentiation (GO:0048762)3.39414276
97galactose catabolic process (GO:0019388)3.38350243
98nephron tubule morphogenesis (GO:0072078)3.38316106
99nephron epithelium morphogenesis (GO:0072088)3.38316106
100virion attachment to host cell (GO:0019062)3.35159353
101adhesion of symbiont to host cell (GO:0044650)3.35159353
102regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.34556338
103detection of temperature stimulus (GO:0016048)3.34410848
104* mesonephric epithelium development (GO:0072163)3.31397853
105* ureteric bud development (GO:0001657)3.31313378
106fibroblast migration (GO:0010761)3.30613521
107embryonic heart tube development (GO:0035050)3.30439604
108endothelium development (GO:0003158)3.29511773
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.27032554
110response to BMP (GO:0071772)3.26825634
111cellular response to BMP stimulus (GO:0071773)3.26825634
112head development (GO:0060322)3.20656013
113neural crest cell development (GO:0014032)3.20138158
114adhesion of symbiont to host (GO:0044406)3.19739826
115* skeletal muscle organ development (GO:0060538)3.19132767
116mesenchymal cell development (GO:0014031)3.18374099
117endoderm development (GO:0007492)3.17596100
118cranial nerve structural organization (GO:0021604)3.17315386
119uterus development (GO:0060065)3.16990164
120ubiquinone metabolic process (GO:0006743)3.16260025
121heart valve morphogenesis (GO:0003179)3.14091265
122mesenchymal cell proliferation (GO:0010463)3.13385783
123terpenoid biosynthetic process (GO:0016114)3.11623787
124* diaphragm development (GO:0060539)3.11481105
125embryonic camera-type eye development (GO:0031076)3.10497154
126* positive regulation of heart growth (GO:0060421)3.09635129
127sex differentiation (GO:0007548)3.09611523
128* male gonad development (GO:0008584)3.08264793
129cardiac septum development (GO:0003279)3.06606088
130embryonic digestive tract development (GO:0048566)3.06515294
131organ induction (GO:0001759)3.06217572
132regulation of vascular endothelial growth factor production (GO:0010574)3.05843967
133poly(A)+ mRNA export from nucleus (GO:0016973)3.05553088
134regulation of receptor binding (GO:1900120)3.04369603
135positive regulation of odontogenesis (GO:0042482)3.01670479
136lymphangiogenesis (GO:0001946)3.00783440
137cell junction maintenance (GO:0034331)2.99071572
138response to parathyroid hormone (GO:0071107)2.98801925
139DNA ligation (GO:0006266)2.98729824
140regulation of meiosis I (GO:0060631)2.96899390
141regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.96238800
142metanephric tubule development (GO:0072170)2.93557848
143metanephric nephron tubule development (GO:0072234)2.93557848
144renal filtration (GO:0097205)2.92994348
145anatomical structure regression (GO:0060033)2.90819840
146* negative regulation of kidney development (GO:0090185)2.90524066
147negative regulation of circadian rhythm (GO:0042754)2.90182706
148anterograde axon cargo transport (GO:0008089)2.89879158
149regulation of non-canonical Wnt signaling pathway (GO:2000050)2.89832434
150renal tubule morphogenesis (GO:0061333)2.89674311
151epithelial tube formation (GO:0072175)2.89641951
152negative regulation of axon guidance (GO:1902668)2.89224265
153* negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.83911730
154respiratory system process (GO:0003016)2.83585835
155nephron epithelium development (GO:0072009)2.83447052
156columnar/cuboidal epithelial cell differentiation (GO:0002065)2.83402999
157* adrenal gland development (GO:0030325)2.83338804
158regulation of DNA endoreduplication (GO:0032875)2.81355271
159enteric nervous system development (GO:0048484)2.81102423
160muscle adaptation (GO:0043500)2.80612868
161* kidney epithelium development (GO:0072073)2.80194600
162negative regulation of androgen receptor signaling pathway (GO:0060766)2.77733218
163synaptonemal complex assembly (GO:0007130)2.77133041
164* regulation of kidney development (GO:0090183)2.76304977
165positive regulation of cardiac muscle tissue development (GO:0055025)2.75750626
166mesodermal cell differentiation (GO:0048333)2.73686274
167peptidyl-proline hydroxylation (GO:0019511)2.73595774
168atrioventricular valve morphogenesis (GO:0003181)2.73578327
169* mesenchyme development (GO:0060485)2.73380941
170* positive regulation of metanephros development (GO:0072216)2.71593072
171midgut development (GO:0007494)2.71003687
172vascular endothelial growth factor signaling pathway (GO:0038084)2.70356018
173otic vesicle formation (GO:0030916)2.69814785
174metanephric nephron epithelium development (GO:0072243)2.69782804
175* metanephric epithelium development (GO:0072207)2.69782804
176DNA methylation involved in gamete generation (GO:0043046)2.68239577
177positive regulation of gastrulation (GO:2000543)2.66784592
178protein heterotrimerization (GO:0070208)2.65131524
179morphogenesis of an epithelial sheet (GO:0002011)2.64442803
180nephron tubule development (GO:0072080)2.62959226
181embryonic skeletal system morphogenesis (GO:0048704)2.61541014
182* positive regulation of kidney development (GO:0090184)2.59151879
183stem cell development (GO:0048864)2.58136843
184forelimb morphogenesis (GO:0035136)2.55686237
185glomerular visceral epithelial cell development (GO:0072015)11.0888092
186cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.3713019
187* glomerular basement membrane development (GO:0032836)10.1179097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.95100218
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.73741231
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.46494101
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65471704
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25404132
6* POU5F1_16153702_ChIP-ChIP_HESCs_Human3.12961360
7* PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.07287360
8PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.96718969
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.87097508
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.76484872
11IGF1R_20145208_ChIP-Seq_DFB_Human2.70199890
12* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.65210033
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.55246612
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54159561
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54159561
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54159561
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50639194
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.49388493
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.48656075
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39980250
21* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.33772299
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.33655151
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32046772
24SALL4_18804426_ChIP-ChIP_XEN_Mouse2.30768071
25* WT1_19549856_ChIP-ChIP_CCG9911_Human2.29453627
26* CBX2_27304074_Chip-Seq_ESCs_Mouse2.26761865
27* RNF2_27304074_Chip-Seq_NSC_Mouse2.24492649
28EP300_21415370_ChIP-Seq_HL-1_Mouse2.12837680
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11078549
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.10060218
31* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98744740
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97085745
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.89945865
34* MYC_18940864_ChIP-ChIP_HL60_Human1.87227139
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.86728738
36* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.83013837
37* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79372228
38* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79372228
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.78026654
40SCL_19346495_ChIP-Seq_HPC-7_Human1.75812033
41CLOCK_20551151_ChIP-Seq_293T_Human1.75294717
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.74955859
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74464376
44EWS_26573619_Chip-Seq_HEK293_Human1.73406804
45* TP53_20018659_ChIP-ChIP_R1E_Mouse1.72857626
46* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69832243
47GATA1_19941826_ChIP-Seq_K562_Human1.67563651
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67275444
49ZNF263_19887448_ChIP-Seq_K562_Human1.66644067
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66089484
51* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63522825
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.62078118
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60337820
54ISL1_27105846_Chip-Seq_CPCs_Mouse1.59599291
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58903351
56LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56868481
57* EZH2_27304074_Chip-Seq_ESCs_Mouse1.55301832
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55170659
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53381764
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52406485
61* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48640621
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48179161
63FUS_26573619_Chip-Seq_HEK293_Human1.47406144
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45587952
65* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44929575
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43919247
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43550051
68* RING1B_27294783_Chip-Seq_NPCs_Mouse1.43517930
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37524026
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36625376
71* RNF2_27304074_Chip-Seq_ESCs_Mouse1.36455430
72BRD4_25478319_ChIP-Seq_HGPS_Human1.35993494
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35792498
74KDM5A_27292631_Chip-Seq_BREAST_Human1.35765324
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35484608
76AR_21909140_ChIP-Seq_LNCAP_Human1.32731439
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32724496
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.32005824
79FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.31972507
80EZH2_22144423_ChIP-Seq_EOC_Human1.31533089
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30982042
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.30944145
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30699441
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28655555
85* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28627512
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.28184155
87* NCOR1_26117541_ChIP-Seq_K562_Human1.24677927
88* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.24335587
89PHF8_20622853_ChIP-Seq_HELA_Human1.23859102
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.22888763
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.22616380
92* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22040953
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.21583852
94* NANOG_16153702_ChIP-ChIP_HESCs_Human1.21130683
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18655386
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17360370
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15987904
98TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14999875
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.14715572
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12884632
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12105533
102GBX2_23144817_ChIP-Seq_PC3_Human1.11639247
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10297096
104* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09135259
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.08923538
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08536703
107XRN2_22483619_ChIP-Seq_HELA_Human1.07254294
108GATA4_21415370_ChIP-Seq_HL-1_Mouse1.04929704
109SOX9_26525672_Chip-Seq_HEART_Mouse1.04542110
110GATA1_22025678_ChIP-Seq_K562_Human1.03995878
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03764576
112ESET_19884257_ChIP-Seq_ESCs_Mouse1.03756101
113NFYB_21822215_ChIP-Seq_K562_Human1.03333922
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03214648
115SOX17_20123909_ChIP-Seq_XEN_Mouse1.02390046
116* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01545781
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00654402
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00654402
119CDX2_22108803_ChIP-Seq_LS180_Human1.00497372
120HNFA_21074721_ChIP-Seq_CACO-2_Human0.98785078
121* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98742377
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98535762
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98004707
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97027217
125GATA6_21074721_ChIP-Seq_CACO-2_Human0.96760885
126SA1_22415368_ChIP-Seq_MEFs_Mouse0.96484525
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96177362
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.95898578
129MYC_18555785_ChIP-Seq_MESCs_Mouse0.94891408
130E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94673514
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94068368
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.93423666
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93404690
134CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92951594
135FOXP3_21729870_ChIP-Seq_TREG_Human0.92739254
136EOMES_21245162_ChIP-Seq_HESCs_Human0.92633046
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.92394520
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.92090239
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92057595
140IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92051884
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91889417
142GABP_19822575_ChIP-Seq_HepG2_Human0.91773815
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91281151
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91051435
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91005587
146SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90939277
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90541654
148GATA2_19941826_ChIP-Seq_K562_Human0.90132244
149VDR_23849224_ChIP-Seq_CD4+_Human0.88037226
150TTF2_22483619_ChIP-Seq_HELA_Human0.87524097
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87347114
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85794267
153EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84722225
154MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84544812
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84294622
156* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83976403
157* TBL1_22424771_ChIP-Seq_293T_Human0.83808731
158* EZH2_27294783_Chip-Seq_ESCs_Mouse0.83574958
159* RING1B_27294783_Chip-Seq_ESCs_Mouse0.81531080
160EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81463912
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80877981
162NFI_21473784_ChIP-Seq_ESCs_Mouse0.80169141
163TP63_17297297_ChIP-ChIP_HaCaT_Human0.79213150
164DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77450607
165TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76720099
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76669082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003942_abnormal_urinary_system3.77281530
2MP0003123_paternal_imprinting3.42139904
3MP0005623_abnormal_meninges_morphology3.37062823
4MP0004272_abnormal_basement_membrane3.30599669
5MP0001879_abnormal_lymphatic_vessel3.12142630
6MP0000534_abnormal_ureter_morphology3.05964792
7MP0003941_abnormal_skin_development3.00836210
8MP0003315_abnormal_perineum_morphology2.74041608
9MP0010368_abnormal_lymphatic_system2.67405318
10MP0005377_hearing/vestibular/ear_phenot2.65327968
11MP0003878_abnormal_ear_physiology2.65327968
12MP0010386_abnormal_urinary_bladder2.61887647
13MP0008995_early_reproductive_senescence2.59202237
14MP0003221_abnormal_cardiomyocyte_apopto2.57501181
15MP0002249_abnormal_larynx_morphology2.50762133
16MP0003385_abnormal_body_wall2.44717930
17MP0010030_abnormal_orbit_morphology2.27625990
18MP0001727_abnormal_embryo_implantation2.15674829
19MP0009053_abnormal_anal_canal2.12767101
20MP0000537_abnormal_urethra_morphology2.07746920
21MP0002132_abnormal_respiratory_system2.06100863
22MP0003195_calcinosis2.03052231
23MP0001764_abnormal_homeostasis2.01642337
24MP0005503_abnormal_tendon_morphology2.00414932
25MP0000516_abnormal_urinary_system1.99356522
26MP0005367_renal/urinary_system_phenotyp1.99356522
27MP0005410_abnormal_fertilization1.96512793
28MP0003122_maternal_imprinting1.92484170
29MP0003121_genomic_imprinting1.88943342
30MP0000049_abnormal_middle_ear1.86742613
31MP0009250_abnormal_appendicular_skeleto1.83740142
32MP0005310_abnormal_salivary_gland1.80242868
33MP0002282_abnormal_trachea_morphology1.76724589
34MP0002160_abnormal_reproductive_system1.74801343
35MP0008877_abnormal_DNA_methylation1.69276462
36MP0002127_abnormal_cardiovascular_syste1.68133328
37MP0003786_premature_aging1.67899307
38* MP0003115_abnormal_respiratory_system1.67383794
39MP0000678_abnormal_parathyroid_gland1.66643188
40MP0004084_abnormal_cardiac_muscle1.65283057
41MP0009384_cardiac_valve_regurgitation1.44130738
42MP0009278_abnormal_bone_marrow1.42761242
43MP0003938_abnormal_ear_development1.42701376
44MP0008057_abnormal_DNA_replication1.42317345
45MP0002938_white_spotting1.40437082
46MP0001542_abnormal_bone_strength1.39817990
47* MP0000639_abnormal_adrenal_gland1.39433857
48* MP0002210_abnormal_sex_determination1.35446757
49MP0003567_abnormal_fetal_cardiomyocyte1.33027374
50MP0003119_abnormal_digestive_system1.32948633
51MP0002009_preneoplasia1.30973741
52MP0005646_abnormal_pituitary_gland1.30107937
53MP0003937_abnormal_limbs/digits/tail_de1.29841009
54MP0002932_abnormal_joint_morphology1.28673122
55MP0008058_abnormal_DNA_repair1.27713033
56MP0003935_abnormal_craniofacial_develop1.26466231
57* MP0002135_abnormal_kidney_morphology1.26252412
58* MP0003936_abnormal_reproductive_system1.26026694
59MP0000767_abnormal_smooth_muscle1.26004791
60MP0009379_abnormal_foot_pigmentation1.22312129
61MP0008007_abnormal_cellular_replicative1.20479095
62MP0001661_extended_life_span1.20124086
63MP0006138_congestive_heart_failure1.19303869
64MP0001188_hyperpigmentation1.15187359
65MP0003656_abnormal_erythrocyte_physiolo1.13893686
66MP0005409_darkened_coat_color1.12860857
67MP0001286_abnormal_eye_development1.12405046
68MP0000566_synostosis1.12281973
69MP0003828_pulmonary_edema1.11057096
70MP0002109_abnormal_limb_morphology1.10172931
71MP0004019_abnormal_vitamin_homeostasis1.08754055
72MP0002233_abnormal_nose_morphology1.07997255
73MP0005220_abnormal_exocrine_pancreas1.07132112
74MP0010094_abnormal_chromosome_stability1.05526627
75MP0005508_abnormal_skeleton_morphology1.05409919
76* MP0001119_abnormal_female_reproductive1.04307673
77MP0004147_increased_porphyrin_level1.03713018
78MP0002114_abnormal_axial_skeleton1.03312263
79MP0003755_abnormal_palate_morphology1.01102730
80* MP0002128_abnormal_blood_circulation1.00403939
81MP0004036_abnormal_muscle_relaxation0.99537302
82MP0002084_abnormal_developmental_patter0.97871106
83* MP0001145_abnormal_male_reproductive0.97709480
84* MP0005389_reproductive_system_phenotype0.95214865
85MP0001915_intracranial_hemorrhage0.93546092
86MP0006054_spinal_hemorrhage0.93128940
87MP0003279_aneurysm0.92282950
88MP0002108_abnormal_muscle_morphology0.92000056
89MP0002115_abnormal_skeleton_extremities0.91924111
90MP0005058_abnormal_lysosome_morphology0.91299721
91MP0002697_abnormal_eye_size0.89877274
92MP0005171_absent_coat_pigmentation0.88879415
93* MP0000653_abnormal_sex_gland0.87947566
94MP0008932_abnormal_embryonic_tissue0.87941170
95MP0005248_abnormal_Harderian_gland0.87814207
96MP0005388_respiratory_system_phenotype0.87080300
97MP0002133_abnormal_respiratory_system0.87080300
98* MP0001614_abnormal_blood_vessel0.86368878
99MP0002177_abnormal_outer_ear0.86308832
100MP0003984_embryonic_growth_retardation0.85174556
101MP0001958_emphysema0.84905924
102* MP0002925_abnormal_cardiovascular_devel0.84872407
103MP0002088_abnormal_embryonic_growth/wei0.84775619
104MP0001853_heart_inflammation0.83415136
105MP0000538_abnormal_urinary_bladder0.83098888
106MP0004233_abnormal_muscle_weight0.82962588
107MP0005197_abnormal_uvea_morphology0.82936092
108MP0000163_abnormal_cartilage_morphology0.82247676
109MP0002116_abnormal_craniofacial_bone0.81705085
110MP0003077_abnormal_cell_cycle0.80608791
111* MP0002085_abnormal_embryonic_tissue0.80382654
112MP0003787_abnormal_imprinting0.79881382
113MP0001293_anophthalmia0.79623886
114MP0004134_abnormal_chest_morphology0.78696210
115MP0005380_embryogenesis_phenotype0.77708954
116MP0001672_abnormal_embryogenesis/_devel0.77708954
117MP0002295_abnormal_pulmonary_circulatio0.77679552
118MP0000428_abnormal_craniofacial_morphol0.77613170
119MP0005647_abnormal_sex_gland0.77219733
120MP0009697_abnormal_copulation0.76526063
121MP0004197_abnormal_fetal_growth/weight/0.76390490
122* MP0003943_abnormal_hepatobiliary_system0.76035848
123MP0010630_abnormal_cardiac_muscle0.75757350
124MP0001544_abnormal_cardiovascular_syste0.74793146
125MP0005385_cardiovascular_system_phenoty0.74793146
126MP0001340_abnormal_eyelid_morphology0.73944893
127MP0000432_abnormal_head_morphology0.73364642
128MP0004957_abnormal_blastocyst_morpholog0.73191880
129* MP0001784_abnormal_fluid_regulation0.73063461
130* MP0001929_abnormal_gametogenesis0.72354493
131MP0002086_abnormal_extraembryonic_tissu0.71387002
132MP0006036_abnormal_mitochondrial_physio0.70738976
133MP0008438_abnormal_cutaneous_collagen0.70647075
134MP0006276_abnormal_autonomic_nervous0.66967264
135MP0005332_abnormal_amino_acid0.64451200
136MP0001730_embryonic_growth_arrest0.63660257
137* MP0003698_abnormal_male_reproductive0.63443962
138MP0005275_abnormal_skin_tensile0.63298590
139MP0001501_abnormal_sleep_pattern0.63162273
140MP0002168_other_aberrant_phenotype0.63061511
141* MP0001697_abnormal_embryo_size0.62742407
142MP0003045_fibrosis0.61699796
143MP0005535_abnormal_body_temperature0.61351424
144MP0004085_abnormal_heartbeat0.61290107
145MP0002332_abnormal_exercise_endurance0.60169234
146MP0001545_abnormal_hematopoietic_system0.59783123
147MP0005397_hematopoietic_system_phenotyp0.59783123
148MP0005376_homeostasis/metabolism_phenot0.58961010
149MP0004484_altered_response_of0.54443668
150MP0003186_abnormal_redox_activity0.53637602
151MP0004145_abnormal_muscle_electrophysio0.52785950
152MP0000749_muscle_degeneration0.52771395
153MP0004808_abnormal_hematopoietic_stem0.52706951
154MP0005595_abnormal_vascular_smooth0.52202189

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)7.35958412
2Degeneration of the lateral corticospinal tracts (HP:0002314)7.35958412
3* Testicular neoplasm (HP:0010788)7.31144273
4Shoulder girdle muscle weakness (HP:0003547)5.64880394
5Abnormality of the corticospinal tract (HP:0002492)5.46615806
6* Mesangial abnormality (HP:0001966)5.33878051
7* Focal segmental glomerulosclerosis (HP:0000097)5.10897912
8Abnormality of the lower motor neuron (HP:0002366)5.00470302
9Abnormality of the vocal cords (HP:0008777)4.85091030
10Diaphragmatic weakness (HP:0009113)4.80494253
11Osteomalacia (HP:0002749)4.74775533
12Hypoalbuminemia (HP:0003073)4.74258204
13Abnormal albumin level (HP:0012116)4.74258204
14Diastasis recti (HP:0001540)4.50273717
15Gonadotropin excess (HP:0000837)4.21358660
16* Stage 5 chronic kidney disease (HP:0003774)4.20801462
17Stridor (HP:0010307)4.17337302
18Upper motor neuron abnormality (HP:0002127)3.84213071
19* Glomerulosclerosis (HP:0000096)3.74096631
20Hepatoblastoma (HP:0002884)3.60805221
21Dry hair (HP:0011359)3.50508090
22Impaired vibration sensation in the lower limbs (HP:0002166)3.49669345
23Renal dysplasia (HP:0000110)3.46959359
24* Gonadal dysgenesis (HP:0000133)3.44554483
25Urinary bladder sphincter dysfunction (HP:0002839)3.37521195
26Bulbar palsy (HP:0001283)3.35970182
27Complete atrioventricular canal defect (HP:0001674)3.33563523
28Amyotrophic lateral sclerosis (HP:0007354)3.33308651
29Shawl scrotum (HP:0000049)3.32326589
30Atrophy/Degeneration involving motor neurons (HP:0007373)3.31131277
31Urethral obstruction (HP:0000796)3.28152392
32Abnormal pancreas size (HP:0012094)3.24295763
33Volvulus (HP:0002580)3.18728831
34Nephritis (HP:0000123)3.18160083
35Rimmed vacuoles (HP:0003805)3.14125099
36Renal duplication (HP:0000075)3.13774413
37Pulmonary artery stenosis (HP:0004415)3.06165370
38Male infertility (HP:0003251)3.02508136
39* Hypoplastic left heart (HP:0004383)3.01674530
40Urinary urgency (HP:0000012)2.95073132
41Supernumerary spleens (HP:0009799)2.92799337
42Bicornuate uterus (HP:0000813)2.92046490
43Potter facies (HP:0002009)2.90594456
44Facial shape deformation (HP:0011334)2.90594456
45* Male pseudohermaphroditism (HP:0000037)2.88613622
46Midline defect of the nose (HP:0004122)2.87498800
47* Primary adrenal insufficiency (HP:0008207)2.85208078
48* Embryonal renal neoplasm (HP:0011794)2.80248262
49Degeneration of anterior horn cells (HP:0002398)2.80027065
50Abnormality of the anterior horn cell (HP:0006802)2.80027065
51* Nephroblastoma (Wilms tumor) (HP:0002667)2.78313979
52* Female pseudohermaphroditism (HP:0010458)2.75371418
53Atrioventricular canal defect (HP:0006695)2.75216748
54Preauricular pit (HP:0004467)2.74199993
55Periauricular skin pits (HP:0100277)2.74199993
56Proximal placement of thumb (HP:0009623)2.71090512
57Metaphyseal dysplasia (HP:0100255)2.67576423
58Tubular atrophy (HP:0000092)2.66358227
59Ankle contracture (HP:0006466)2.63211610
60Biconcave vertebral bodies (HP:0004586)2.58299035
61Sex reversal (HP:0012245)2.57735036
62Abnormal sex determination (HP:0012244)2.57735036
63Beaking of vertebral bodies (HP:0004568)2.57473117
64Hypoplasia of the uterus (HP:0000013)2.54757641
65Clumsiness (HP:0002312)2.53882678
66Rectal prolapse (HP:0002035)2.53577473
67Deviation of the thumb (HP:0009603)2.49438820
68Tachypnea (HP:0002789)2.47362039
69Hypoproteinemia (HP:0003075)2.46623617
70Coronal craniosynostosis (HP:0004440)2.46532234
71Abnormality of the fingertips (HP:0001211)2.39019784
72Abnormality of the lacrimal duct (HP:0011481)2.38520005
73Intestinal atresia (HP:0011100)2.36096020
74* Nephrotic syndrome (HP:0000100)2.35336108
75* Hypoplastic heart (HP:0001961)2.32004456
76Enlarged kidneys (HP:0000105)2.31418040
77Arthropathy (HP:0003040)2.30323964
78Vitreoretinal degeneration (HP:0000655)2.29842950
79Broad toe (HP:0001837)2.29683582
80Metaphyseal cupping (HP:0003021)2.28669104
81Renal hypoplasia (HP:0000089)2.28298806
82Papilledema (HP:0001085)2.27734372
8311 pairs of ribs (HP:0000878)2.27108816
84Abnormality of the aortic arch (HP:0012303)2.26654532
85Corneal erosion (HP:0200020)2.25590601
86Preaxial foot polydactyly (HP:0001841)2.25046878
87Hand muscle atrophy (HP:0009130)2.24597643
88Occipital encephalocele (HP:0002085)2.23846062
89Abnormality of male internal genitalia (HP:0000022)2.22517576
90Abnormality of the nasolacrimal system (HP:0000614)2.21282417
91Limb-girdle muscle weakness (HP:0003325)2.21040265
92Spastic paraplegia (HP:0001258)2.17676951
93Vertebral compression fractures (HP:0002953)2.13512818
94* Ovarian neoplasm (HP:0100615)2.12980714
95* Abnormal lung lobation (HP:0002101)2.12934542
96Broad metatarsal (HP:0001783)2.11824773
97Glomerulonephritis (HP:0000099)2.08050155
98Nonprogressive disorder (HP:0003680)2.07953402
99Morphological abnormality of the middle ear (HP:0008609)2.07279206
100Vaginal atresia (HP:0000148)2.04703960
101Spinal cord lesions (HP:0100561)2.04559667
102Syringomyelia (HP:0003396)2.04559667
103Selective tooth agenesis (HP:0001592)2.04541537
104* Abnormal ventriculo-arterial connection (HP:0011563)2.03546856
105* Transposition of the great arteries (HP:0001669)2.03546856
106* Abnormal connection of the cardiac segments (HP:0011545)2.03546856
107Aplasia/Hypoplasia of the tibia (HP:0005772)2.01999192
108Tongue fasciculations (HP:0001308)2.01856130
109Aplastic anemia (HP:0001915)2.01536051
110Broad palm (HP:0001169)2.00521289
111Underdeveloped supraorbital ridges (HP:0009891)1.99634504
112Azoospermia (HP:0000027)1.99155489
113* Germ cell neoplasia (HP:0100728)1.97957619
114Genital tract atresia (HP:0001827)1.97384548
115Colon cancer (HP:0003003)1.96961188
116Broad thumb (HP:0011304)1.96655844
117Patent foramen ovale (HP:0001655)1.94499986
118Short 4th metacarpal (HP:0010044)1.94487749
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94487749
120Paraplegia (HP:0010550)1.93758958
121Pterygium (HP:0001059)1.93426874
122Fibular hypoplasia (HP:0003038)1.93241445
123Chorioretinal atrophy (HP:0000533)1.92102491
124Pulmonic stenosis (HP:0001642)1.90887431
125Spastic gait (HP:0002064)1.90683316
126Nasolacrimal duct obstruction (HP:0000579)1.89623843
127Impaired proprioception (HP:0010831)1.89041608
128Absent eyebrow (HP:0002223)1.88916148
129Abnormality of the nasal septum (HP:0000419)1.88414766
130Coarctation of aorta (HP:0001680)1.87950753
131Sprengel anomaly (HP:0000912)1.87420374
132Hydroureter (HP:0000072)1.87116737
133Broad finger (HP:0001500)1.85004808
134Lower limb muscle weakness (HP:0007340)1.83061661
135Lymphangioma (HP:0100764)1.82717373
136Delayed epiphyseal ossification (HP:0002663)1.80910152
137* Proteinuria (HP:0000093)1.79048133
138Abnormality of the calcaneus (HP:0008364)1.78423273
139Pancreatic islet-cell hyperplasia (HP:0004510)1.77932493
140Abnormal spermatogenesis (HP:0008669)1.77925911
141Irregular epiphyses (HP:0010582)1.77686049
142Ridged nail (HP:0001807)1.75766925
143Meckel diverticulum (HP:0002245)1.75590485
144Skin pits (HP:0100276)1.75090178
145Patellar aplasia (HP:0006443)1.73605115
146Broad phalanges of the hand (HP:0009768)1.73122012
147Testicular atrophy (HP:0000029)1.72980810
148Infertility (HP:0000789)1.72770874
149Truncus arteriosus (HP:0001660)1.72495682
150Adrenal hypoplasia (HP:0000835)1.72309780
151Bifid tongue (HP:0010297)1.71847257
152Abnormality of the ileum (HP:0001549)1.71764467
153Spinal muscular atrophy (HP:0007269)1.70042284
154Abnormality of the radial head (HP:0003995)1.69929356
155Aplasia/hypoplasia of the uterus (HP:0008684)1.69541781
156Protrusio acetabuli (HP:0003179)1.69408138
157Calcaneovalgus deformity (HP:0001848)1.68554211
158Partial duplication of thumb phalanx (HP:0009944)1.68483049
159Hyperventilation (HP:0002883)1.67008487
160Abnormal neuron morphology (HP:0012757)1.66791740
161Abnormality of the motor neurons (HP:0002450)1.66791740
162Chronic hepatic failure (HP:0100626)1.65909332
163Proximal tubulopathy (HP:0000114)1.65188555
164Impaired vibratory sensation (HP:0002495)1.64990020
165Upper limb amyotrophy (HP:0009129)1.61990195
166Distal upper limb amyotrophy (HP:0007149)1.61990195
167Broad forehead (HP:0000337)1.60759745
168Muscle fibrillation (HP:0010546)1.59640061
169Neonatal short-limb short stature (HP:0008921)1.59114034
170Nausea (HP:0002018)1.55005492
171* Tetralogy of Fallot (HP:0001636)1.54647951
172Abnormality of DNA repair (HP:0003254)1.53933266
173Myopathic facies (HP:0002058)1.51591135
174Thin bony cortex (HP:0002753)1.51456345
175Urinary incontinence (HP:0000020)1.51085743
176Abnormality of the pupil (HP:0000615)1.48029755
177Flattened epiphyses (HP:0003071)1.47208257
178Mask-like facies (HP:0000298)1.43835254
179Ankle clonus (HP:0011448)1.43582096
180Hypoplastic pelvis (HP:0008839)1.42289142
181Morphological abnormality of the pyramidal tract (HP:0002062)1.41319953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.71719465
2EPHB23.56497845
3BMPR23.28643704
4MYLK3.26755526
5MKNK13.14642659
6TIE13.07786171
7LATS12.98754234
8AKT32.84544394
9SRPK12.72315211
10TGFBR12.58155467
11MKNK22.42936530
12PRKD32.29480811
13STK392.26953765
14CDK192.17070291
15EIF2AK32.09337737
16PASK2.08162119
17RPS6KA22.08054021
18MAP3K62.03740144
19NEK92.02665036
20CDK71.82949295
21PDK21.79950916
22PAK41.79801069
23PLK41.78009045
24WNK11.69837132
25MAP2K21.68610036
26YES11.66182369
27EEF2K1.64889800
28RIPK41.57873393
29PRPF4B1.50685839
30CAMKK21.47558688
31ERBB31.47081570
32CASK1.45489274
33SGK21.45259718
34NUAK11.44463026
35TGFBR21.43332466
36STK38L1.41036923
37PDGFRA1.36560811
38CSNK1G11.36275269
39TAOK21.34385180
40CLK11.31077393
41MAP3K11.30541248
42OXSR11.29607085
43BRD41.28472154
44CDK121.28279108
45TYRO31.21404622
46RPS6KB21.19522370
47TNK21.19396095
48STK31.19198484
49EPHB11.18659883
50FRK1.17891201
51PLK21.14409082
52PTK2B1.13882859
53WEE11.10963504
54KDR1.10917937
55CDC71.08153471
56CDK81.05005166
57PAK11.04715034
58ACVR1B1.03443040
59PINK11.02670433
60PLK30.99256928
61CDK90.98942220
62BRSK10.98685483
63SGK10.98408468
64PRKAA20.96278621
65MARK30.95478356
66RPS6KA10.95373466
67NEK60.94703183
68MAPKAPK50.90304705
69MATK0.87952256
70ATR0.87400815
71CHEK20.87360274
72MUSK0.85802768
73BMPR1B0.83346497
74MELK0.83259821
75CHUK0.83177802
76WNK30.82852201
77CDK40.81754771
78DYRK1A0.80727023
79PLK10.79748203
80MINK10.79636424
81CDK30.79136861
82STK40.78042698
83CCNB10.77426966
84PKN20.75974724
85FER0.73100316
86SGK30.72780525
87AURKA0.72771426
88MARK20.70833975
89ILK0.70801659
90SGK4940.70392160
91SGK2230.70392160
92BRSK20.70272589
93PTK60.69982010
94PRKD20.69745904
95TNIK0.67743321
96ERN10.66270485
97FGFR10.65800274
98NEK20.64456348
99PTK20.63701767
100PAK20.61332247
101MAPK130.60904318
102EIF2AK10.60794213
103MAP3K20.60793822
104RPS6KC10.60774623
105RPS6KL10.60774623
106DYRK30.59086982
107IKBKB0.58586711
108BRAF0.58261185
109GRK10.57070790
110RPS6KA60.56982965
111ATM0.56901696
112ICK0.55647077
113NTRK30.54959265
114AURKB0.53311024
115TRIB30.52862060
116CAMK40.51796123
117RAF10.50301082
118BMX0.50157010
119TRPM70.49834170
120CSNK1G30.48632726
121EIF2AK20.48544566
122VRK10.48165258
123ZAK0.47226589
124RIPK10.46903606
125KSR20.46244164
126TTK0.44822405
127MAP2K40.44434379
128PIM10.43651995
129CHEK10.43174853
130* RPS6KA30.42432010
131MAP3K40.41909841
132BUB10.41348473
133TEC0.41001428
134NLK0.40949459
135MAP2K70.39836729
136RPS6KB10.39511871
137GSK3A0.38551784
138PRKDC0.38011954
139CDK10.37308574
140PRKAA10.37212044
141RET0.36908055
142MTOR0.36553047
143PRKACB0.36330682
144MAPK30.35900163
145CAMK2B0.35670868
146TSSK60.35598878
147ROCK10.34430435
148PRKCE0.33950657
149CSNK2A10.33914418
150RPS6KA50.33450476
151MAPK140.33288096
152IRAK10.32923572
153MAPK10.32723522
154KSR10.32594606
155CDK20.31762621

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.75834128
2Base excision repair_Homo sapiens_hsa034103.10468443
3ECM-receptor interaction_Homo sapiens_hsa045122.98322839
4DNA replication_Homo sapiens_hsa030302.97353565
5Propanoate metabolism_Homo sapiens_hsa006402.87513819
6Mismatch repair_Homo sapiens_hsa034302.79296938
7Homologous recombination_Homo sapiens_hsa034402.64154104
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62038039
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.48061329
10Small cell lung cancer_Homo sapiens_hsa052222.45383608
11TGF-beta signaling pathway_Homo sapiens_hsa043502.27005321
12Cell cycle_Homo sapiens_hsa041102.22440897
13Nucleotide excision repair_Homo sapiens_hsa034202.17482625
14Hedgehog signaling pathway_Homo sapiens_hsa043402.07659663
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04618965
16Spliceosome_Homo sapiens_hsa030402.02651289
17Basal cell carcinoma_Homo sapiens_hsa052172.00955858
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.99090009
19Fanconi anemia pathway_Homo sapiens_hsa034601.98845840
20Focal adhesion_Homo sapiens_hsa045101.86998666
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81882658
22Hippo signaling pathway_Homo sapiens_hsa043901.81282735
23Pyruvate metabolism_Homo sapiens_hsa006201.80909702
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76595055
25Axon guidance_Homo sapiens_hsa043601.76174973
26Basal transcription factors_Homo sapiens_hsa030221.75860667
27mTOR signaling pathway_Homo sapiens_hsa041501.72824462
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69757709
29RNA degradation_Homo sapiens_hsa030181.68872441
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63301150
31Thyroid cancer_Homo sapiens_hsa052161.59330116
32RNA polymerase_Homo sapiens_hsa030201.59048379
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52206873
34Adherens junction_Homo sapiens_hsa045201.47820605
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46975424
36mRNA surveillance pathway_Homo sapiens_hsa030151.44965812
37Protein digestion and absorption_Homo sapiens_hsa049741.43473613
38Prostate cancer_Homo sapiens_hsa052151.40379542
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38154728
40RNA transport_Homo sapiens_hsa030131.38101098
41Ovarian steroidogenesis_Homo sapiens_hsa049131.37521054
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35927713
43Notch signaling pathway_Homo sapiens_hsa043301.32971362
44Galactose metabolism_Homo sapiens_hsa000521.28714757
45Amoebiasis_Homo sapiens_hsa051461.28482209
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24223667
47PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22918416
48Complement and coagulation cascades_Homo sapiens_hsa046101.21307829
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18230995
50Pathways in cancer_Homo sapiens_hsa052001.17518532
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16581178
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12996241
53Pyrimidine metabolism_Homo sapiens_hsa002401.12650555
54MicroRNAs in cancer_Homo sapiens_hsa052061.11799287
55Dilated cardiomyopathy_Homo sapiens_hsa054141.10588118
56Wnt signaling pathway_Homo sapiens_hsa043101.10467548
57* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10088805
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08505943
59Purine metabolism_Homo sapiens_hsa002301.07747224
60Lysine degradation_Homo sapiens_hsa003101.07307366
61N-Glycan biosynthesis_Homo sapiens_hsa005101.05167510
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04866041
63Proteoglycans in cancer_Homo sapiens_hsa052051.04053765
64Carbon metabolism_Homo sapiens_hsa012001.03802899
65HTLV-I infection_Homo sapiens_hsa051661.01123499
66Sulfur relay system_Homo sapiens_hsa041220.99814215
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99263630
68Tight junction_Homo sapiens_hsa045300.98557643
69Herpes simplex infection_Homo sapiens_hsa051680.97875046
70Protein export_Homo sapiens_hsa030600.97652304
71Folate biosynthesis_Homo sapiens_hsa007900.95978619
72Dorso-ventral axis formation_Homo sapiens_hsa043200.93563408
73Arginine and proline metabolism_Homo sapiens_hsa003300.93551573
74Arachidonic acid metabolism_Homo sapiens_hsa005900.89615050
75Renin-angiotensin system_Homo sapiens_hsa046140.89361680
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88806942
77Fatty acid elongation_Homo sapiens_hsa000620.88589997
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88381643
79Viral myocarditis_Homo sapiens_hsa054160.87117781
80Non-homologous end-joining_Homo sapiens_hsa034500.81178535
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.80914428
82Linoleic acid metabolism_Homo sapiens_hsa005910.79025390
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78137848
84Oocyte meiosis_Homo sapiens_hsa041140.77879982
85Butanoate metabolism_Homo sapiens_hsa006500.77393810
86Melanoma_Homo sapiens_hsa052180.77021589
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75697564
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74602253
89Chemical carcinogenesis_Homo sapiens_hsa052040.74285996
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.73956660
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73590124
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69095083
93Peroxisome_Homo sapiens_hsa041460.68650133
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67447469
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66449409
96Endometrial cancer_Homo sapiens_hsa052130.65824379
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.65538923
98Pentose phosphate pathway_Homo sapiens_hsa000300.64852572
99Bladder cancer_Homo sapiens_hsa052190.63806873
100Rap1 signaling pathway_Homo sapiens_hsa040150.63446829
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63006446
102Melanogenesis_Homo sapiens_hsa049160.62183093
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61468833
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59822674
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58855291
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58806506
107p53 signaling pathway_Homo sapiens_hsa041150.57868884
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56962531
109Glutathione metabolism_Homo sapiens_hsa004800.56918414
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55708145
111One carbon pool by folate_Homo sapiens_hsa006700.52388982
112Fatty acid metabolism_Homo sapiens_hsa012120.52328186
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.52307362
114Retinol metabolism_Homo sapiens_hsa008300.51933065
115ABC transporters_Homo sapiens_hsa020100.51847162
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51592943
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.51540815
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.50307481
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50158950
120Pancreatic cancer_Homo sapiens_hsa052120.49835486
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48620245
122Metabolic pathways_Homo sapiens_hsa011000.48618201
123Steroid biosynthesis_Homo sapiens_hsa001000.47690447
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47437632
125Colorectal cancer_Homo sapiens_hsa052100.47384105
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45542696
127Ribosome_Homo sapiens_hsa030100.45345951
128Selenocompound metabolism_Homo sapiens_hsa004500.43917328
129Sulfur metabolism_Homo sapiens_hsa009200.42860377
130Vitamin digestion and absorption_Homo sapiens_hsa049770.42123216
131Fatty acid degradation_Homo sapiens_hsa000710.41608516
132Choline metabolism in cancer_Homo sapiens_hsa052310.41476131
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40731848
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37174990
135Ether lipid metabolism_Homo sapiens_hsa005650.37152102
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36430669
137Viral carcinogenesis_Homo sapiens_hsa052030.36262768
138AMPK signaling pathway_Homo sapiens_hsa041520.35643456
139Insulin resistance_Homo sapiens_hsa049310.33402457
140Epstein-Barr virus infection_Homo sapiens_hsa051690.31877586
141Acute myeloid leukemia_Homo sapiens_hsa052210.31807140
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.31591335
143Ras signaling pathway_Homo sapiens_hsa040140.31285823
144cAMP signaling pathway_Homo sapiens_hsa040240.30709440
145Sphingolipid metabolism_Homo sapiens_hsa006000.30244706
146Calcium signaling pathway_Homo sapiens_hsa040200.29827207
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29676703
148Toxoplasmosis_Homo sapiens_hsa051450.29580081
149Influenza A_Homo sapiens_hsa051640.29356824
150Chronic myeloid leukemia_Homo sapiens_hsa052200.28261381
151Non-small cell lung cancer_Homo sapiens_hsa052230.26733213
152Hepatitis B_Homo sapiens_hsa051610.26452224
153Platelet activation_Homo sapiens_hsa046110.26223152
154Renin secretion_Homo sapiens_hsa049240.24423616
155Mineral absorption_Homo sapiens_hsa049780.23829678

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