WTAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.93154523
2DNA replication checkpoint (GO:0000076)4.80348916
3metaphase plate congression (GO:0051310)4.67522715
4DNA double-strand break processing (GO:0000729)4.53496879
5proteasome assembly (GO:0043248)4.43252363
6transcription elongation from RNA polymerase III promoter (GO:0006385)4.42298244
7termination of RNA polymerase III transcription (GO:0006386)4.42298244
8purine nucleobase biosynthetic process (GO:0009113)4.34772483
9ribosome biogenesis (GO:0042254)4.28701975
10regulation of cytokine secretion involved in immune response (GO:0002739)4.27790286
11ribosome assembly (GO:0042255)4.26051405
12rRNA modification (GO:0000154)4.25506757
13regulation of heat generation (GO:0031650)4.19903610
14regulation of vitamin D biosynthetic process (GO:0060556)4.15882296
15regulation of double-strand break repair via homologous recombination (GO:0010569)4.15711058
16maturation of SSU-rRNA (GO:0030490)4.13369288
17transcription from RNA polymerase I promoter (GO:0006360)4.06717118
18regulation of spindle organization (GO:0090224)4.05320870
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.99582748
20GMP metabolic process (GO:0046037)3.99215319
21maturation of 5.8S rRNA (GO:0000460)3.99060876
22CENP-A containing nucleosome assembly (GO:0034080)3.98959118
23termination of RNA polymerase I transcription (GO:0006363)3.98150485
24positive regulation of heat generation (GO:0031652)3.96248314
25transcription elongation from RNA polymerase I promoter (GO:0006362)3.96183205
267-methylguanosine mRNA capping (GO:0006370)3.93095205
27kinetochore assembly (GO:0051382)3.89630158
28regulation of chronic inflammatory response (GO:0002676)3.89410673
29RNA capping (GO:0036260)3.88100773
307-methylguanosine RNA capping (GO:0009452)3.88100773
31establishment of chromosome localization (GO:0051303)3.87978309
32ribonucleoprotein complex biogenesis (GO:0022613)3.83049897
33regulation of fever generation (GO:0031620)3.80956025
34nucleobase biosynthetic process (GO:0046112)3.80514526
35tryptophan catabolic process (GO:0006569)3.78807196
36indole-containing compound catabolic process (GO:0042436)3.78807196
37indolalkylamine catabolic process (GO:0046218)3.78807196
38chromatin remodeling at centromere (GO:0031055)3.77406177
39kinetochore organization (GO:0051383)3.74623511
40positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.74027740
41DNA deamination (GO:0045006)3.71947036
42transcription initiation from RNA polymerase I promoter (GO:0006361)3.69548569
43protein K6-linked ubiquitination (GO:0085020)3.66497366
44protein localization to kinetochore (GO:0034501)3.64021455
45kynurenine metabolic process (GO:0070189)3.62446529
46DNA replication initiation (GO:0006270)3.58900803
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53791373
48regulation of transcription from RNA polymerase I promoter (GO:0006356)3.53028572
49rRNA processing (GO:0006364)3.52214814
50platelet dense granule organization (GO:0060155)3.51239182
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50882657
52protein localization to chromosome, centromeric region (GO:0071459)3.48862425
53spliceosomal snRNP assembly (GO:0000387)3.47827016
54ribosomal large subunit biogenesis (GO:0042273)3.46666448
55DNA replication-independent nucleosome assembly (GO:0006336)3.46361242
56DNA replication-independent nucleosome organization (GO:0034724)3.46361242
57transcription elongation from RNA polymerase II promoter (GO:0006368)3.46010328
58branching involved in labyrinthine layer morphogenesis (GO:0060670)3.45048556
59microtubule depolymerization (GO:0007019)3.43529457
60rRNA methylation (GO:0031167)3.42605237
61rRNA metabolic process (GO:0016072)3.42582480
62histone exchange (GO:0043486)3.41383267
63inner cell mass cell proliferation (GO:0001833)3.41216891
64spindle checkpoint (GO:0031577)3.40290110
65DNA-templated transcription, elongation (GO:0006354)3.38574403
66negative regulation of DNA-dependent DNA replication (GO:2000104)3.37174743
67positive regulation of chemokine biosynthetic process (GO:0045080)3.32519108
68positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.32162794
69regulation of histone H3-K27 methylation (GO:0061085)3.31579071
70lung-associated mesenchyme development (GO:0060484)3.31166896
71positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.30483756
72regulation of T-helper 1 cell differentiation (GO:0045625)3.27832817
73positive regulation of chromosome segregation (GO:0051984)3.26721911
74regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.24338904
75somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.19978042
76somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.19978042
77isotype switching (GO:0045190)3.19978042
78transcription-coupled nucleotide-excision repair (GO:0006283)3.19210645
79positive regulation of viral transcription (GO:0050434)3.16486768
80regulation of interferon-alpha production (GO:0032647)3.15933995
81ribosomal small subunit biogenesis (GO:0042274)3.14684382
82regulation of mitotic spindle organization (GO:0060236)3.14242935
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14170776
84negative regulation of interleukin-12 production (GO:0032695)3.13939968
85tryptophan metabolic process (GO:0006568)3.13384591
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.10804945
87meiosis I (GO:0007127)3.09447439
88DNA-dependent DNA replication (GO:0006261)3.09268277
89spliceosomal complex assembly (GO:0000245)3.08379850
90folic acid metabolic process (GO:0046655)3.06927057
91regulation of exit from mitosis (GO:0007096)3.04038949
92attachment of spindle microtubules to kinetochore (GO:0008608)3.03624094
93telomere maintenance via semi-conservative replication (GO:0032201)3.02613191
94ribosomal small subunit assembly (GO:0000028)3.00827957
95regulation of chemokine biosynthetic process (GO:0045073)3.00361274
96mitotic spindle checkpoint (GO:0071174)2.99797860
97telomere maintenance via recombination (GO:0000722)2.99007542
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98280475
99meiotic chromosome segregation (GO:0045132)2.97908784
100regulation of vitamin metabolic process (GO:0030656)2.97374958
101viral mRNA export from host cell nucleus (GO:0046784)2.95003441
102pseudouridine synthesis (GO:0001522)2.94932787
103DNA strand elongation involved in DNA replication (GO:0006271)2.94814793
104RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94384542
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94318881
106DNA-templated transcription, termination (GO:0006353)2.93569291
107regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.93300833
108regulation of immunoglobulin secretion (GO:0051023)2.89021779
109positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.86683554
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85409295
111DNA strand elongation (GO:0022616)2.83806764
112regulation of chromosome segregation (GO:0051983)2.83274940
113negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.82005790
114negative regulation of DNA-templated transcription, elongation (GO:0032785)2.82005790
115mitotic recombination (GO:0006312)2.81365875
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80862314
117neural tube formation (GO:0001841)2.80068307
118blastocyst development (GO:0001824)2.78931225
119replication fork processing (GO:0031297)2.78450515
120cellular component biogenesis (GO:0044085)2.78157780
121keratinocyte development (GO:0003334)2.78104621
122double-strand break repair via homologous recombination (GO:0000724)2.76949622
123regulation of DNA methylation (GO:0044030)2.76917840
124recombinational repair (GO:0000725)2.76203877
125regulation of mononuclear cell migration (GO:0071675)2.76192590
126male meiosis I (GO:0007141)2.76051024
127mitotic nuclear envelope disassembly (GO:0007077)2.75266843
128mitotic G2/M transition checkpoint (GO:0044818)2.74663321
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74635336
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.74255514
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74255514
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74255514
133negative regulation of sister chromatid segregation (GO:0033046)2.74255514
134negative regulation of chromosome segregation (GO:0051985)2.73222928
135folic acid transport (GO:0015884)2.72428947
136mitotic sister chromatid segregation (GO:0000070)2.71786696
137regulation of interleukin-8 biosynthetic process (GO:0045414)2.71388537
138protein K11-linked deubiquitination (GO:0035871)2.66550275
139positive regulation of interferon-beta production (GO:0032728)2.65338837
140response to lipoprotein particle (GO:0055094)2.62100866
141regulation of MHC class II biosynthetic process (GO:0045346)2.60992585
142indolalkylamine metabolic process (GO:0006586)2.60650960
143amine catabolic process (GO:0009310)2.58485469
144cellular biogenic amine catabolic process (GO:0042402)2.58485469
145regulation of B cell apoptotic process (GO:0002902)2.57093867
146negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.56270187
147synapsis (GO:0007129)2.55796035
148adenosine metabolic process (GO:0046085)2.54096622
149positive regulation of nitric oxide biosynthetic process (GO:0045429)2.53967049
150negative regulation of mast cell activation (GO:0033004)2.52868413
151lactate metabolic process (GO:0006089)2.51674881
152mitotic G2 DNA damage checkpoint (GO:0007095)2.51253193
153regulation of mitotic spindle checkpoint (GO:1903504)2.50576452
154regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50576452
155positive regulation of interferon-alpha production (GO:0032727)2.46818360
156DNA catabolic process, exonucleolytic (GO:0000738)2.45192030
157positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.44792381
158purine nucleotide salvage (GO:0032261)2.43021036
159positive regulation of prostaglandin secretion (GO:0032308)2.42352734
160histone H2A acetylation (GO:0043968)2.41975259
161glial cell proliferation (GO:0014009)2.41328895
162positive regulation of NF-kappaB import into nucleus (GO:0042346)2.39655862
163regulation of meiosis I (GO:0060631)2.38497146
164response to peptidoglycan (GO:0032494)2.38384795
165regulation of nitric oxide biosynthetic process (GO:0045428)2.37076370
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36302468
167regulation of T-helper cell differentiation (GO:0045622)2.36089741
168positive regulation of protein autophosphorylation (GO:0031954)2.35133276
169B cell activation involved in immune response (GO:0002312)2.35016260
170positive regulation of interleukin-12 production (GO:0032735)2.34770595
171negative regulation of nitric oxide biosynthetic process (GO:0045019)2.33826066
172negative regulation of lipid storage (GO:0010888)2.33774608
173response to pheromone (GO:0019236)2.29764243
174purine-containing compound salvage (GO:0043101)2.28958534
175nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.28628102
176regulation of inflammatory response to antigenic stimulus (GO:0002861)2.28579644
177regulation of prostaglandin secretion (GO:0032306)2.28457239
178regulation of glutamate secretion (GO:0014048)2.26110692
179regulation of amino acid transport (GO:0051955)2.25643028
180response to protozoan (GO:0001562)2.25635073
181protein prenylation (GO:0018342)2.25418630
182prenylation (GO:0097354)2.25418630
183DNA replication-dependent nucleosome organization (GO:0034723)2.25326784
184DNA replication-dependent nucleosome assembly (GO:0006335)2.25326784
185respiratory chain complex IV assembly (GO:0008535)2.24656903
186negative regulation of growth of symbiont in host (GO:0044130)2.24514149
187negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.24514149
188modulation of growth of symbiont involved in interaction with host (GO:0044144)2.24514149
189regulation of growth of symbiont in host (GO:0044126)2.24514149
190sphingosine metabolic process (GO:0006670)2.24116070
191positive regulation of glycoprotein biosynthetic process (GO:0010560)2.23680994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.08983644
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.15060350
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.16322269
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89723359
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.78535370
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.58445337
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42038094
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.30256065
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.20477047
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15828996
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.06947841
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95097883
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92217646
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91723812
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82307056
16ZNF274_21170338_ChIP-Seq_K562_Hela2.79658417
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72135600
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65411583
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60128360
20VDR_22108803_ChIP-Seq_LS180_Human2.55429697
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45983830
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.42351065
23* VDR_23849224_ChIP-Seq_CD4+_Human2.41335999
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41211789
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.36211365
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33778652
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29128085
28EWS_26573619_Chip-Seq_HEK293_Human2.28468487
29IRF8_22096565_ChIP-ChIP_GC-B_Human2.25296948
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.24743729
31IGF1R_20145208_ChIP-Seq_DFB_Human2.24124539
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19876294
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19654122
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10212784
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09887776
36P300_19829295_ChIP-Seq_ESCs_Human2.02986381
37NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02239401
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00918586
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00180233
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99141139
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95514765
42FOXP3_21729870_ChIP-Seq_TREG_Human1.91736355
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91297263
44* XRN2_22483619_ChIP-Seq_HELA_Human1.89700906
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88561170
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88192306
47ELK1_19687146_ChIP-ChIP_HELA_Human1.84302419
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83465535
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.83344634
50FUS_26573619_Chip-Seq_HEK293_Human1.82172398
51GBX2_23144817_ChIP-Seq_PC3_Human1.82064107
52* AR_21909140_ChIP-Seq_LNCAP_Human1.81484728
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81241670
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.80330217
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77752079
56TTF2_22483619_ChIP-Seq_HELA_Human1.76320045
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76105901
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75838135
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.73040943
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72177096
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68690470
62DCP1A_22483619_ChIP-Seq_HELA_Human1.67283186
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66973793
64TAF15_26573619_Chip-Seq_HEK293_Human1.66267719
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.58841479
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58425568
67GABP_19822575_ChIP-Seq_HepG2_Human1.56050677
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54370469
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54254587
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53854833
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52808214
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.51734844
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51170083
74ER_23166858_ChIP-Seq_MCF-7_Human1.50721234
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.49888708
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48474015
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48234654
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.48007614
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46191930
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44725369
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.44293654
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43065993
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43059834
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41839527
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40677195
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40571370
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40571370
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40571370
89NANOG_19829295_ChIP-Seq_ESCs_Human1.39351854
90SOX2_19829295_ChIP-Seq_ESCs_Human1.39351854
91MYC_18940864_ChIP-ChIP_HL60_Human1.39272179
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.38922666
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37603798
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35896953
95CBP_20019798_ChIP-Seq_JUKART_Human1.35896953
96P53_22387025_ChIP-Seq_ESCs_Mouse1.35168179
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33367237
98BCAT_22108803_ChIP-Seq_LS180_Human1.33030769
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32610039
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30854616
101P300_18555785_Chip-Seq_ESCs_Mouse1.30089685
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.29293545
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.29004962
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28739733
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27290274
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26009664
107AR_25329375_ChIP-Seq_VCAP_Human1.25964900
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25911319
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25756978
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.25699575
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25447322
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25301089
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25145594
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24100503
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24092473
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23518656
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22528218
118THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22420371
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22059240
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21463411
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21221821
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.21107659
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19849883
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.19158783
125STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19010466
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.18442744
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18384899
128IRF1_19129219_ChIP-ChIP_H3396_Human1.18291363
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17578475
130KDM5A_27292631_Chip-Seq_BREAST_Human1.17540119
131* CDX2_22108803_ChIP-Seq_LS180_Human1.15645197
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15194450
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14665191
134VDR_24787735_ChIP-Seq_THP-1_Human1.13561993
135GATA3_26560356_Chip-Seq_TH2_Human1.12823555
136SMAD4_21799915_ChIP-Seq_A2780_Human1.12339390
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11844086
138SOX2_18555785_Chip-Seq_ESCs_Mouse1.11030245
139SALL1_21062744_ChIP-ChIP_HESCs_Human1.09950062
140NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09616386
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09164165
142OCT4_18555785_Chip-Seq_ESCs_Mouse1.07173143
143KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05858016
144NMYC_18555785_Chip-Seq_ESCs_Mouse1.05852787
145* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05516321
146TCF4_22108803_ChIP-Seq_LS180_Human1.05393670
147ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05359986
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04683617
149TP53_22573176_ChIP-Seq_HFKS_Human1.04467865
150PU1_27457419_Chip-Seq_LIVER_Mouse1.04361297
151KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03439589
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03313013
153TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02277098
154CIITA_25753668_ChIP-Seq_RAJI_Human1.01728769
155PIAS1_25552417_ChIP-Seq_VCAP_Human1.00724545
156SMAD4_21741376_ChIP-Seq_EPCs_Human1.00379758
157SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99290104
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97562927
159NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96571853
160* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94978448
161ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94004437
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93758283
163EGR1_19374776_ChIP-ChIP_THP-1_Human0.92765702
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92705666
165SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90382530
166SPI1_23547873_ChIP-Seq_NB4_Human0.88950655
167TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88076569
168TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86549425
169BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85607051
170SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85538677
171* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81897296
172* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80193229
173PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75711617
174NFE2_27457419_Chip-Seq_LIVER_Mouse0.72902803
175* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72814929
176* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70210432
177NANOG_16153702_ChIP-ChIP_HESCs_Human0.70159972
178* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.70097985
179* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.69502777
180SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68972036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.73268921
2MP0003136_yellow_coat_color4.43899641
3MP0003195_calcinosis4.17556821
4MP0003718_maternal_effect4.14452853
5MP0003111_abnormal_nucleus_morphology3.87696590
6MP0006054_spinal_hemorrhage3.81180722
7MP0003303_peritoneal_inflammation3.78805775
8MP0010094_abnormal_chromosome_stability3.31025123
9MP0002254_reproductive_system_inflammat3.27339180
10MP0004957_abnormal_blastocyst_morpholog3.23469883
11MP0003077_abnormal_cell_cycle3.04140349
12MP0004381_abnormal_hair_follicle2.96450883
13MP0006292_abnormal_olfactory_placode2.89565497
14MP0003315_abnormal_perineum_morphology2.78899893
15MP0008057_abnormal_DNA_replication2.77943286
16MP0009785_altered_susceptibility_to2.76916304
17MP0001188_hyperpigmentation2.73831011
18MP0002148_abnormal_hypersensitivity_rea2.73669252
19MP0008260_abnormal_autophagy2.70219825
20MP0008058_abnormal_DNA_repair2.69254075
21MP0006082_CNS_inflammation2.62246152
22MP0008007_abnormal_cellular_replicative2.53202072
23MP0009764_decreased_sensitivity_to2.41539964
24MP0005167_abnormal_blood-brain_barrier2.35841372
25MP0003786_premature_aging2.18871838
26MP0008932_abnormal_embryonic_tissue2.15674564
27MP0002139_abnormal_hepatobiliary_system2.05539167
28MP0002837_dystrophic_cardiac_calcinosis2.04624847
29MP0005409_darkened_coat_color1.93298914
30MP0002102_abnormal_ear_morphology1.86477887
31MP0000015_abnormal_ear_pigmentation1.80120670
32MP0001835_abnormal_antigen_presentation1.77669402
33MP0004510_myositis1.73699821
34MP0003787_abnormal_imprinting1.73460356
35MP0005000_abnormal_immune_tolerance1.69425019
36MP0002396_abnormal_hematopoietic_system1.67921041
37MP0005647_abnormal_sex_gland1.60102711
38MP0006072_abnormal_retinal_apoptosis1.59174803
39MP0003938_abnormal_ear_development1.57520046
40MP0003806_abnormal_nucleotide_metabolis1.54531536
41MP0000566_synostosis1.54313942
42MP0009333_abnormal_splenocyte_physiolog1.52941505
43MP0005395_other_phenotype1.52767206
44MP0002277_abnormal_respiratory_mucosa1.51855173
45MP0000350_abnormal_cell_proliferation1.48579719
46MP0009697_abnormal_copulation1.47943674
47MP0001501_abnormal_sleep_pattern1.44985420
48MP0005310_abnormal_salivary_gland1.43264734
49MP0001790_abnormal_immune_system1.42180177
50MP0005387_immune_system_phenotype1.42180177
51MP0008877_abnormal_DNA_methylation1.42006640
52MP0003937_abnormal_limbs/digits/tail_de1.40608517
53MP0001764_abnormal_homeostasis1.40480279
54MP0003646_muscle_fatigue1.39934195
55MP0002210_abnormal_sex_determination1.37331572
56MP0001730_embryonic_growth_arrest1.34660415
57MP0005075_abnormal_melanosome_morpholog1.33959604
58MP0002452_abnormal_antigen_presenting1.33873331
59MP0002138_abnormal_hepatobiliary_system1.33428851
60MP0002332_abnormal_exercise_endurance1.32233903
61MP0002419_abnormal_innate_immunity1.31764698
62MP0000372_irregular_coat_pigmentation1.30308298
63MP0009379_abnormal_foot_pigmentation1.30100825
64MP0002723_abnormal_immune_serum1.29513260
65MP0005174_abnormal_tail_pigmentation1.29066326
66MP0003656_abnormal_erythrocyte_physiolo1.29021817
67MP0002160_abnormal_reproductive_system1.27333312
68MP0005253_abnormal_eye_physiology1.27165435
69MP0002009_preneoplasia1.26976599
70MP0005025_abnormal_response_to1.26335636
71MP0002095_abnormal_skin_pigmentation1.23679657
72MP0001800_abnormal_humoral_immune1.22900387
73MP0005451_abnormal_body_composition1.21425716
74MP0005248_abnormal_Harderian_gland1.21111787
75MP0002638_abnormal_pupillary_reflex1.19838811
76MP0005408_hypopigmentation1.19175422
77MP0000490_abnormal_crypts_of1.18965020
78MP0001845_abnormal_inflammatory_respons1.17163271
79MP0001119_abnormal_female_reproductive1.14699831
80MP0001919_abnormal_reproductive_system1.14555334
81MP0005389_reproductive_system_phenotype1.14013067
82MP0008995_early_reproductive_senescence1.12908957
83* MP0001672_abnormal_embryogenesis/_devel1.12721616
84* MP0005380_embryogenesis_phenotype1.12721616
85MP0008004_abnormal_stomach_pH1.11298830
86MP0002132_abnormal_respiratory_system1.11262486
87MP0001145_abnormal_male_reproductive1.10045566
88MP0003567_abnormal_fetal_cardiomyocyte1.09156998
89MP0003123_paternal_imprinting1.09102136
90MP0008469_abnormal_protein_level1.05458366
91MP0000653_abnormal_sex_gland1.04387193
92MP0001929_abnormal_gametogenesis1.02683814
93MP0001819_abnormal_immune_cell1.02378118
94MP0003186_abnormal_redox_activity1.02270981
95MP0002085_abnormal_embryonic_tissue1.02156898
96MP0002420_abnormal_adaptive_immunity1.02066356
97MP0002090_abnormal_vision1.01528981
98MP0003436_decreased_susceptibility_to1.01466964
99MP0003121_genomic_imprinting0.99842660
100MP0003941_abnormal_skin_development0.97882186
101MP0002405_respiratory_system_inflammati0.97778909
102MP0010307_abnormal_tumor_latency0.97445390
103MP0010352_gastrointestinal_tract_polyps0.97422734
104MP0001286_abnormal_eye_development0.95194697
105MP0003724_increased_susceptibility_to0.95061718
106MP0004043_abnormal_pH_regulation0.94544500
107MP0002177_abnormal_outer_ear0.94241620
108MP0005266_abnormal_metabolism0.94076383
109MP0000343_altered_response_to0.93833293
110MP0002019_abnormal_tumor_incidence0.93063122
111MP0000313_abnormal_cell_death0.92928680
112MP0005410_abnormal_fertilization0.92555455
113MP0005379_endocrine/exocrine_gland_phen0.91154597
114MP0009765_abnormal_xenobiotic_induced0.90684011
115MP0001697_abnormal_embryo_size0.89743075
116MP0003699_abnormal_female_reproductive0.88963358
117MP0001661_extended_life_span0.88402988
118MP0000647_abnormal_sebaceous_gland0.87404100
119MP0003984_embryonic_growth_retardation0.86777035
120MP0010678_abnormal_skin_adnexa0.86488648
121MP0002088_abnormal_embryonic_growth/wei0.86130206
122MP0005671_abnormal_response_to0.85180854
123* MP0002080_prenatal_lethality0.84579730
124MP0003221_abnormal_cardiomyocyte_apopto0.84318831
125MP0000627_abnormal_mammary_gland0.84165475
126MP0001853_heart_inflammation0.83906858
127MP0003828_pulmonary_edema0.83802117
128MP0010155_abnormal_intestine_physiology0.81270012
129MP0005377_hearing/vestibular/ear_phenot0.79443385
130MP0003878_abnormal_ear_physiology0.79443385
131MP0003763_abnormal_thymus_physiology0.77854340
132MP0003075_altered_response_to0.77848704
133MP0000569_abnormal_digit_pigmentation0.76799599
134MP0003448_altered_tumor_morphology0.76601910
135MP0008873_increased_physiological_sensi0.74540292
136MP0005367_renal/urinary_system_phenotyp0.73944255
137MP0000516_abnormal_urinary_system0.73944255
138MP0000716_abnormal_immune_system0.73593392
139MP0000428_abnormal_craniofacial_morphol0.73574615
140MP0005166_decreased_susceptibility_to0.72929974
141MP0009046_muscle_twitch0.72474926
142MP0001542_abnormal_bone_strength0.72432600
143MP0004808_abnormal_hematopoietic_stem0.72155902
144MP0003936_abnormal_reproductive_system0.71944379
145MP0009763_increased_sensitivity_to0.71837596
146MP0002693_abnormal_pancreas_physiology0.71356257
147MP0002398_abnormal_bone_marrow0.71273407
148MP0002751_abnormal_autonomic_nervous0.70484978
149MP0005551_abnormal_eye_electrophysiolog0.69885573
150MP0003172_abnormal_lysosome_physiology0.69695147
151MP0001545_abnormal_hematopoietic_system0.68753039
152MP0005397_hematopoietic_system_phenotyp0.68753039
153MP0006036_abnormal_mitochondrial_physio0.68480101
154MP0002163_abnormal_gland_morphology0.68440442
155MP0000858_altered_metastatic_potential0.68274085
156MP0002168_other_aberrant_phenotype0.68255614
157MP0000613_abnormal_salivary_gland0.68181828
158MP0001191_abnormal_skin_condition0.67888301
159MP0002092_abnormal_eye_morphology0.67736622
160MP0002938_white_spotting0.67700255
161MP0005084_abnormal_gallbladder_morpholo0.66517874
162MP0002722_abnormal_immune_system0.66354769
163MP0000689_abnormal_spleen_morphology0.65912675
164MP0000432_abnormal_head_morphology0.65721271
165MP0001293_anophthalmia0.64810890
166MP0002086_abnormal_extraembryonic_tissu0.64167866
167MP0000703_abnormal_thymus_morphology0.62367231
168MP0000383_abnormal_hair_follicle0.62234730
169MP0003755_abnormal_palate_morphology0.60919588
170MP0000465_gastrointestinal_hemorrhage0.60494272

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.98733011
2Breast hypoplasia (HP:0003187)4.95442368
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.28411964
4Impulsivity (HP:0100710)4.18412401
5Abnormality of secondary sexual hair (HP:0009888)4.10505029
6Abnormality of the axillary hair (HP:0100134)4.10505029
7Aplasia/Hypoplasia of the patella (HP:0006498)3.99911824
8Patellar aplasia (HP:0006443)3.93346745
9Chromsome breakage (HP:0040012)3.93277403
10Carpal bone hypoplasia (HP:0001498)3.91689961
11Abnormality of B cell number (HP:0010975)3.57327537
12Sex reversal (HP:0012245)3.55577091
13Abnormal sex determination (HP:0012244)3.55577091
14Stomatitis (HP:0010280)3.55193523
15B lymphocytopenia (HP:0010976)3.52979002
16Meckel diverticulum (HP:0002245)3.52067473
17Thyroiditis (HP:0100646)3.45867188
18Hyperglycinemia (HP:0002154)3.25251814
19Abnormality of the ileum (HP:0001549)3.23389956
20Intestinal atresia (HP:0011100)3.22511585
21Absent radius (HP:0003974)3.20681469
22Disinhibition (HP:0000734)3.18014889
23Abnormality of the preputium (HP:0100587)3.16766107
24Hematochezia (HP:0002573)3.12160071
25Capillary hemangiomas (HP:0005306)3.06425731
26Absent forearm bone (HP:0003953)3.05359182
27Aplasia involving forearm bones (HP:0009822)3.05359182
28Volvulus (HP:0002580)2.95205776
29Abnormality of chromosome stability (HP:0003220)2.90838685
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89053517
31Combined immunodeficiency (HP:0005387)2.86545333
32Rough bone trabeculation (HP:0100670)2.78881507
33Agnosia (HP:0010524)2.78756294
34Prostate neoplasm (HP:0100787)2.77363274
35Severe combined immunodeficiency (HP:0004430)2.75314024
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.73415329
37Retrobulbar optic neuritis (HP:0100654)2.73237660
38Optic neuritis (HP:0100653)2.73237660
39Horseshoe kidney (HP:0000085)2.69759858
40Reticulocytopenia (HP:0001896)2.66161650
41Aplasia/Hypoplasia involving the musculature (HP:0001460)2.60522209
42Secondary amenorrhea (HP:0000869)2.55665112
43True hermaphroditism (HP:0010459)2.54890109
44Absent thumb (HP:0009777)2.53135220
45Bone marrow hypocellularity (HP:0005528)2.47567849
46Inappropriate behavior (HP:0000719)2.47204146
47Abnormal spermatogenesis (HP:0008669)2.46619268
48Triphalangeal thumb (HP:0001199)2.45926511
49Cerebral hypomyelination (HP:0006808)2.44684173
50Abnormality of the labia minora (HP:0012880)2.43897688
51Abnormality of the anterior horn cell (HP:0006802)2.41895344
52Degeneration of anterior horn cells (HP:0002398)2.41895344
53Vacuolated lymphocytes (HP:0001922)2.38996430
54Abnormality of midbrain morphology (HP:0002418)2.36736749
55Molar tooth sign on MRI (HP:0002419)2.36736749
56Aplasia/hypoplasia of the uterus (HP:0008684)2.36272194
57Abnormality of liposaccharide metabolism (HP:0010968)2.36000678
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.36000678
59Abnormality of glycolipid metabolism (HP:0010969)2.36000678
60Clubbing of toes (HP:0100760)2.33132694
61Facial hemangioma (HP:0000329)2.31917530
62Abolished electroretinogram (ERG) (HP:0000550)2.31639932
63Supernumerary spleens (HP:0009799)2.27588280
64Parakeratosis (HP:0001036)2.25881913
65Abnormal trabecular bone morphology (HP:0100671)2.23090871
66Duodenal stenosis (HP:0100867)2.21220117
67Small intestinal stenosis (HP:0012848)2.21220117
68Stomach cancer (HP:0012126)2.20508579
69Colon cancer (HP:0003003)2.19632793
70Congenital, generalized hypertrichosis (HP:0004540)2.18004290
71Hypoplasia of the radius (HP:0002984)2.17868201
72Mutism (HP:0002300)2.17470454
73Abnormal number of erythroid precursors (HP:0012131)2.17122421
74Oral leukoplakia (HP:0002745)2.16879655
75Aplasia/Hypoplasia of the earlobes (HP:0009906)2.16138578
76Abnormality of cells of the erythroid lineage (HP:0012130)2.15433610
77Rhabdomyosarcoma (HP:0002859)2.15186199
78Hyperglycinuria (HP:0003108)2.15042291
79Nephronophthisis (HP:0000090)2.15012218
80Short thumb (HP:0009778)2.14832239
81Methylmalonic acidemia (HP:0002912)2.14205475
82Macrocytic anemia (HP:0001972)2.13705327
83Azoospermia (HP:0000027)2.12860603
84Prolonged neonatal jaundice (HP:0006579)2.12674855
85Ureteral duplication (HP:0000073)2.12279750
86Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10952500
87Ectopic kidney (HP:0000086)2.10654117
88Orchitis (HP:0100796)2.10430549
89Pancreatic fibrosis (HP:0100732)2.10207007
90Glioma (HP:0009733)2.09571817
91Entropion (HP:0000621)2.09405177
92Pancreatic cysts (HP:0001737)2.06722441
93Adactyly (HP:0009776)2.06215237
94Keratoconjunctivitis (HP:0001096)2.06002651
95Hypothermia (HP:0002045)2.05925086
96Myelodysplasia (HP:0002863)2.04270243
97Neoplasm of the adrenal cortex (HP:0100641)2.04094809
98Autoimmune thrombocytopenia (HP:0001973)2.03359750
99Erythroderma (HP:0001019)2.02132075
100Neoplasm of the pancreas (HP:0002894)2.01900097
101Premature ovarian failure (HP:0008209)2.00848444
102Aplasia/Hypoplasia of the breasts (HP:0010311)1.99854427
103Breast aplasia (HP:0100783)1.99461981
104Nausea (HP:0002018)1.98660539
105Breast carcinoma (HP:0003002)1.95772320
106Type 2 muscle fiber atrophy (HP:0003554)1.94406971
107Aplasia/Hypoplasia of the ulna (HP:0006495)1.94005712
108Sparse eyelashes (HP:0000653)1.92667904
109Hypoproteinemia (HP:0003075)1.92567885
110Premature graying of hair (HP:0002216)1.92550747
111Keratoconjunctivitis sicca (HP:0001097)1.92153468
112Pendular nystagmus (HP:0012043)1.92112151
113Microretrognathia (HP:0000308)1.91586709
114Renal cortical cysts (HP:0000803)1.91463327
115Abnormality of the renal cortex (HP:0011035)1.88990772
116Cleft eyelid (HP:0000625)1.86774369
117Sloping forehead (HP:0000340)1.86332824
118Albinism (HP:0001022)1.85286262
1193-Methylglutaconic aciduria (HP:0003535)1.85221578
120Abnormal lung lobation (HP:0002101)1.84465256
121Concave nail (HP:0001598)1.83943474
122Ependymoma (HP:0002888)1.83912397
123Sparse lateral eyebrow (HP:0005338)1.82673531
124Abnormality of the umbilical cord (HP:0010881)1.82365375
125Muscle fiber atrophy (HP:0100295)1.82345627
126Abnormal biliary tract physiology (HP:0012439)1.82158865
127Bile duct proliferation (HP:0001408)1.82158865
128Pallor (HP:0000980)1.80968250
129Pancreatic islet-cell hyperplasia (HP:0004510)1.80852886
130Tracheoesophageal fistula (HP:0002575)1.80198877
131Methylmalonic aciduria (HP:0012120)1.79395164
132Split foot (HP:0001839)1.79385316
133Pustule (HP:0200039)1.78980632
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.78573785
135Abnormality of the septum pellucidum (HP:0007375)1.78229144
136Abnormality of the renal medulla (HP:0100957)1.78206289
137Abnormality of the duodenum (HP:0002246)1.77159088
138Abnormality of the clitoris (HP:0000056)1.77141793
139Abnormality of eosinophils (HP:0001879)1.76515692
140Type I transferrin isoform profile (HP:0003642)1.75202841
141Astrocytoma (HP:0009592)1.74367286
142Abnormality of the astrocytes (HP:0100707)1.74367286
143Gonadotropin excess (HP:0000837)1.73743194
144Absent speech (HP:0001344)1.73742591
145Aplastic anemia (HP:0001915)1.73562923
146Fair hair (HP:0002286)1.71501728
147Abnormal rod and cone electroretinograms (HP:0008323)1.71020934
148Small hand (HP:0200055)1.70993468
149Abnormality of the columella (HP:0009929)1.69692984
150Medulloblastoma (HP:0002885)1.69553836
151Congenital stationary night blindness (HP:0007642)1.69317215
152Clitoromegaly (HP:0000057)1.68449271
153Limb hypertonia (HP:0002509)1.68166696
154Adrenal hypoplasia (HP:0000835)1.68005735
155Eosinophilia (HP:0001880)1.67446105
156Medial flaring of the eyebrow (HP:0010747)1.66078139
157Oligodactyly (HP:0012165)1.65397218
158Leukocytosis (HP:0001974)1.64984710
159Oligodactyly (hands) (HP:0001180)1.64836619
160CNS hypomyelination (HP:0003429)1.64542404
161Abnormality of male internal genitalia (HP:0000022)1.64534521
162Anal stenosis (HP:0002025)1.64214978
163Progressive macrocephaly (HP:0004481)1.63957141
164Intrahepatic cholestasis (HP:0001406)1.63477139
165IgG deficiency (HP:0004315)1.63304193
166Chronic obstructive pulmonary disease (HP:0006510)1.63270066
167Obstructive lung disease (HP:0006536)1.63270066
168Abnormality of the prostate (HP:0008775)1.63108926
169Myositis (HP:0100614)1.61939619
170Ascites (HP:0001541)1.61867245
171Congenital hepatic fibrosis (HP:0002612)1.61067962
172Autoimmune hemolytic anemia (HP:0001890)1.60700386
173Progressive inability to walk (HP:0002505)1.60477047
174Dyskinesia (HP:0100660)1.59459670
175Abnormality of the vasculature of the conjunctiva (HP:0008054)1.58421884
176Abnormality of T cell number (HP:0011839)1.55139403
177Aplasia/Hypoplasia of the tibia (HP:0005772)1.54479571
178Constricted visual fields (HP:0001133)1.54392579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.21830837
2FRK3.91571183
3BUB13.87624485
4WEE13.85010390
5MKNK13.76194134
6SRPK13.74122197
7TRIM283.19538211
8ERBB32.86495219
9WNK32.86285180
10CASK2.80753618
11TLK12.73027276
12EIF2AK12.67360214
13STK162.52155000
14PLK42.47932633
15EPHA22.45132470
16MAP4K22.39924175
17BMPR1B2.35333627
18IRAK32.23964972
19BRSK22.22454947
20AKT32.21242233
21SIK32.06577836
22NME22.03759469
23ADRBK22.03744254
24EIF2AK31.90975272
25BCR1.88336037
26ACVR1B1.72632325
27MAPK131.72486089
28PLK11.72376843
29GRK71.69510484
30PLK31.67400760
31VRK11.65015664
32TTK1.61211222
33NEK21.61206706
34ZAK1.60091797
35PLK21.58819240
36CDC71.57333337
37EIF2AK21.54190070
38MAP3K41.50047754
39DYRK31.49391498
40STK38L1.47597684
41TSSK61.34834046
42CSNK1G21.29582326
43BLK1.28329028
44CHEK21.19934487
45MATK1.17866997
46CSNK1A1L1.15959538
47IRAK41.15231154
48PNCK1.13057609
49BRAF1.12854127
50AURKB1.12591771
51MUSK1.12241640
52LATS21.11950875
53NLK1.05437498
54NUAK11.02457262
55BRSK10.98525861
56TAOK10.95793482
57AURKA0.94804094
58TGFBR20.93671930
59CDK70.92741436
60CDK30.90519528
61STK30.90500899
62PIM10.86549135
63DYRK20.84415345
64FER0.82894415
65NEK60.81502677
66PAK10.81250096
67STK240.80082332
68RPS6KA40.79771798
69PKN10.79515303
70CDK40.79503077
71PINK10.74412377
72PRKCI0.72816843
73PAK30.72727515
74TBK10.72329082
75PIM20.72048382
76MAP2K70.71587659
77NEK10.70767236
78TESK20.70031758
79STK390.69161097
80TGFBR10.68655120
81CSNK1G10.68227853
82FGR0.67356301
83LATS10.66915736
84DDR20.66780431
85YES10.63224458
86ARAF0.62552991
87MST40.62128403
88CHEK10.57471612
89DYRK1A0.56623110
90STK40.56178332
91INSRR0.55894281
92OXSR10.55775859
93IRAK10.55329041
94CSNK2A10.53816621
95RPS6KA50.53685771
96IKBKB0.53503092
97ATR0.52355796
98IRAK20.52158398
99PRKCE0.51275332
100TAF10.49100942
101MAP3K80.48904087
102MAP3K50.47177519
103BRD40.46907983
104EPHA30.45858006
105GRK10.45790794
106MARK30.45144293
107* CDK20.44827420
108NME10.44571362
109BMPR20.43201843
110ATM0.43169623
111TYK20.43052695
112RPS6KB20.42420187
113CSNK2A20.42130322
114ABL10.41811839
115TAOK30.41684147
116CAMKK20.41516300
117NEK90.40288887
118TXK0.40115968
119ABL20.38108381
120PHKG10.37993852
121PHKG20.37993852
122EGFR0.37893668
123MAP3K140.36905995
124CSNK1G30.36666109
125PIK3CG0.35980986
126CDK10.35768143
127CDK60.32316215
128MELK0.31062465
129IKBKE0.30547405
130TEC0.29852914
131PRKAA20.29800599
132TNIK0.29266334
133ERBB40.28372155
134RAF10.28217092
135CCNB10.27444022
136CSNK1A10.27167744
137CLK10.27020981
138STK100.26936737
139FGFR20.26559000
140CSNK1E0.24407162
141CHUK0.20578367
142LYN0.19611890
143CDK80.18137156

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.77237481
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.01289364
3Vitamin B6 metabolism_Homo sapiens_hsa007503.44462433
4DNA replication_Homo sapiens_hsa030303.17666975
5Homologous recombination_Homo sapiens_hsa034403.04682216
6Proteasome_Homo sapiens_hsa030503.01871921
7Ribosome_Homo sapiens_hsa030103.00445479
8Spliceosome_Homo sapiens_hsa030402.97242244
9Fanconi anemia pathway_Homo sapiens_hsa034602.93085616
10RNA transport_Homo sapiens_hsa030132.90414073
11Basal transcription factors_Homo sapiens_hsa030222.84318055
12Pyrimidine metabolism_Homo sapiens_hsa002402.68307993
13Mismatch repair_Homo sapiens_hsa034302.64979786
14Cell cycle_Homo sapiens_hsa041102.63054115
15Rheumatoid arthritis_Homo sapiens_hsa053232.47411133
16Legionellosis_Homo sapiens_hsa051342.42584972
17Nucleotide excision repair_Homo sapiens_hsa034202.24225324
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21932563
19Base excision repair_Homo sapiens_hsa034102.06506813
20p53 signaling pathway_Homo sapiens_hsa041151.97113956
21Type I diabetes mellitus_Homo sapiens_hsa049401.95402952
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82981321
23African trypanosomiasis_Homo sapiens_hsa051431.76213844
24Regulation of autophagy_Homo sapiens_hsa041401.73052671
25Purine metabolism_Homo sapiens_hsa002301.68786393
26RNA degradation_Homo sapiens_hsa030181.67382847
27Steroid biosynthesis_Homo sapiens_hsa001001.67104247
28TNF signaling pathway_Homo sapiens_hsa046681.58009391
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54836901
30Pertussis_Homo sapiens_hsa051331.49030303
31One carbon pool by folate_Homo sapiens_hsa006701.47510994
32Malaria_Homo sapiens_hsa051441.43020625
33Non-homologous end-joining_Homo sapiens_hsa034501.41744707
34Osteoclast differentiation_Homo sapiens_hsa043801.34058841
35Collecting duct acid secretion_Homo sapiens_hsa049661.30964176
36mRNA surveillance pathway_Homo sapiens_hsa030151.30537375
37Staphylococcus aureus infection_Homo sapiens_hsa051501.27577638
38Folate biosynthesis_Homo sapiens_hsa007901.27266742
39Epstein-Barr virus infection_Homo sapiens_hsa051691.24581664
40Propanoate metabolism_Homo sapiens_hsa006401.16151171
41Tuberculosis_Homo sapiens_hsa051521.14107254
42Leishmaniasis_Homo sapiens_hsa051401.12764761
43Tryptophan metabolism_Homo sapiens_hsa003801.11235315
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09827972
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09775997
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07579018
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06531983
48Herpes simplex infection_Homo sapiens_hsa051681.01526418
49Butanoate metabolism_Homo sapiens_hsa006500.98225739
50Salmonella infection_Homo sapiens_hsa051320.96145340
51Oocyte meiosis_Homo sapiens_hsa041140.95970572
52Vitamin digestion and absorption_Homo sapiens_hsa049770.92808576
53Lysosome_Homo sapiens_hsa041420.91590716
54Sphingolipid metabolism_Homo sapiens_hsa006000.91470482
55Arachidonic acid metabolism_Homo sapiens_hsa005900.89229547
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.88838729
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88743134
58Pentose phosphate pathway_Homo sapiens_hsa000300.88667902
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88150553
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85687698
61Protein export_Homo sapiens_hsa030600.84957509
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.84190669
63Sulfur metabolism_Homo sapiens_hsa009200.82962300
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82608431
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76954514
66Systemic lupus erythematosus_Homo sapiens_hsa053220.74885936
67Primary immunodeficiency_Homo sapiens_hsa053400.74401353
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.73412792
69Caffeine metabolism_Homo sapiens_hsa002320.72658262
70Antigen processing and presentation_Homo sapiens_hsa046120.72260220
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71932823
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67591695
73Sulfur relay system_Homo sapiens_hsa041220.67042850
74Phototransduction_Homo sapiens_hsa047440.64754290
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.64657358
76Other glycan degradation_Homo sapiens_hsa005110.64470805
77Circadian rhythm_Homo sapiens_hsa047100.64342773
78Ether lipid metabolism_Homo sapiens_hsa005650.62810787
79MicroRNAs in cancer_Homo sapiens_hsa052060.62339274
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60422760
81Peroxisome_Homo sapiens_hsa041460.59991754
82Viral carcinogenesis_Homo sapiens_hsa052030.59389273
83Measles_Homo sapiens_hsa051620.57937504
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56638071
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56333223
86Thyroid cancer_Homo sapiens_hsa052160.55317488
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.54717837
88Mineral absorption_Homo sapiens_hsa049780.54028089
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52511317
90Shigellosis_Homo sapiens_hsa051310.52264905
91Toxoplasmosis_Homo sapiens_hsa051450.51856020
92HTLV-I infection_Homo sapiens_hsa051660.50432854
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48973478
94Graft-versus-host disease_Homo sapiens_hsa053320.48519604
95Fatty acid elongation_Homo sapiens_hsa000620.47059531
96Autoimmune thyroid disease_Homo sapiens_hsa053200.43896952
97Hematopoietic cell lineage_Homo sapiens_hsa046400.43806873
98Allograft rejection_Homo sapiens_hsa053300.43640794
99Hepatitis C_Homo sapiens_hsa051600.43267536
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42080011
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41513794
102FoxO signaling pathway_Homo sapiens_hsa040680.41380291
103Linoleic acid metabolism_Homo sapiens_hsa005910.40798475
104Nitrogen metabolism_Homo sapiens_hsa009100.39076526
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37891004
106Prostate cancer_Homo sapiens_hsa052150.37524062
107Huntingtons disease_Homo sapiens_hsa050160.37406668
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36868055
109Asthma_Homo sapiens_hsa053100.35299831
110Small cell lung cancer_Homo sapiens_hsa052220.34740844
111Chemokine signaling pathway_Homo sapiens_hsa040620.32425510
112Hepatitis B_Homo sapiens_hsa051610.32336530
113Influenza A_Homo sapiens_hsa051640.32149548
114Oxidative phosphorylation_Homo sapiens_hsa001900.32094975
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.30137933
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30031703
117Phagosome_Homo sapiens_hsa041450.27038598
118Selenocompound metabolism_Homo sapiens_hsa004500.25748769
119Metabolic pathways_Homo sapiens_hsa011000.25122430
120TGF-beta signaling pathway_Homo sapiens_hsa043500.24186582
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23804125
122Apoptosis_Homo sapiens_hsa042100.22902372
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20861900
124Glutathione metabolism_Homo sapiens_hsa004800.18923726
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18213518
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.18092064
127Pathways in cancer_Homo sapiens_hsa052000.18058203
128Renal cell carcinoma_Homo sapiens_hsa052110.17658245
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17553027
130Notch signaling pathway_Homo sapiens_hsa043300.16044054
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.15855981
132Basal cell carcinoma_Homo sapiens_hsa052170.14446903
133Wnt signaling pathway_Homo sapiens_hsa043100.14282508
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13253007
135Hippo signaling pathway_Homo sapiens_hsa043900.13107864
136Acute myeloid leukemia_Homo sapiens_hsa052210.12449309
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12239770
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11762541
139Hedgehog signaling pathway_Homo sapiens_hsa043400.10155023

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