ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.31143066
2	behavioral response to nicotine (GO:0035095)	4.30469002
3	L-fucose catabolic process (GO:0042355)	3.99547658
4	fucose catabolic process (GO:0019317)	3.99547658
5	L-fucose metabolic process (GO:0042354)	3.99547658
6	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.84101733
7	protein polyglutamylation (GO:0018095)	3.73350495
8	cell wall macromolecule metabolic process (GO:0044036)	3.68961319
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.55235713
10	cellular ketone body metabolic process (GO:0046950)	3.51297175
11	regulation of cilium movement (GO:0003352)	3.51275538
12	positive regulation of meiosis (GO:0045836)	3.49325909
13	epithelial cilium movement (GO:0003351)	3.45608211
14	regulation of meiosis I (GO:0060631)	3.36934240
15	retinal cone cell development (GO:0046549)	3.36879579
16	behavioral response to ethanol (GO:0048149)	3.34346060
17	positive regulation of meiotic cell cycle (GO:0051446)	3.34238751
18	photoreceptor cell maintenance (GO:0045494)	3.28312605
19	tachykinin receptor signaling pathway (GO:0007217)	3.25583783
20	neural tube formation (GO:0001841)	3.20692590
21	detection of light stimulus involved in visual perception (GO:0050908)	3.17446994
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.17446994
23	tryptophan catabolic process (GO:0006569)	3.14528197
24	indole-containing compound catabolic process (GO:0042436)	3.14528197
25	indolalkylamine catabolic process (GO:0046218)	3.14528197
26	mannosylation (GO:0097502)	3.14100513
27	ketone body metabolic process (GO:1902224)	3.13302406
28	cullin deneddylation (GO:0010388)	3.12342441
29	indolalkylamine metabolic process (GO:0006586)	3.11080589
30	axoneme assembly (GO:0035082)	3.10118069
31	kynurenine metabolic process (GO:0070189)	3.08495344
32	gamma-aminobutyric acid transport (GO:0015812)	3.07044703
33	auditory receptor cell stereocilium organization (GO:0060088)	3.04089275
34	piRNA metabolic process (GO:0034587)	3.04020757
35	cilium morphogenesis (GO:0060271)	3.01933719
36	proteasome assembly (GO:0043248)	3.01731633
37	cilium movement (GO:0003341)	2.99646943
38	cornea development in camera-type eye (GO:0061303)	2.97038248
39	preassembly of GPI anchor in ER membrane (GO:0016254)	2.94830246
40	DNA deamination (GO:0045006)	2.92372260
41	protein deneddylation (GO:0000338)	2.92344100
42	inner ear receptor stereocilium organization (GO:0060122)	2.90785611
43	organic cation transport (GO:0015695)	2.90768925
44	C4-dicarboxylate transport (GO:0015740)	2.88821154
45	retinal ganglion cell axon guidance (GO:0031290)	2.84506562
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.83035903
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.83035903
48	NADH dehydrogenase complex assembly (GO:0010257)	2.83035903
49	adult feeding behavior (GO:0008343)	2.82849013
50	nonmotile primary cilium assembly (GO:0035058)	2.82806981
51	protein neddylation (GO:0045116)	2.80931680
52	platelet dense granule organization (GO:0060155)	2.80908162
53	protein complex biogenesis (GO:0070271)	2.79485376
54	cilium organization (GO:0044782)	2.77741508
55	negative regulation of telomere maintenance (GO:0032205)	2.75958774
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75505026
57	respiratory chain complex IV assembly (GO:0008535)	2.75299735
58	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.74897230
59	tryptophan metabolic process (GO:0006568)	2.74315374
60	positive regulation of mitochondrial fission (GO:0090141)	2.73453565
61	water-soluble vitamin biosynthetic process (GO:0042364)	2.73355862
62	reflex (GO:0060004)	2.71789870
63	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.71559855
64	cilium assembly (GO:0042384)	2.71401144
65	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70379358
66	cilium or flagellum-dependent cell motility (GO:0001539)	2.70224510
67	DNA double-strand break processing (GO:0000729)	2.69504462
68	acrosome reaction (GO:0007340)	2.66209548
69	negative regulation of systemic arterial blood pressure (GO:0003085)	2.65110452
70	sulfation (GO:0051923)	2.63686804
71	protein K11-linked deubiquitination (GO:0035871)	2.63641576
72	protein localization to cilium (GO:0061512)	2.62559126
73	exogenous drug catabolic process (GO:0042738)	2.60361176
74	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.59025948
75	sperm motility (GO:0030317)	2.58917815
76	dopamine transport (GO:0015872)	2.58192149
77	protein-cofactor linkage (GO:0018065)	2.57972108
78	presynaptic membrane assembly (GO:0097105)	2.56299655
79	photoreceptor cell development (GO:0042461)	2.55760292
80	neurotransmitter metabolic process (GO:0042133)	2.55381509
81	proline transport (GO:0015824)	2.54807171
82	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.54544175
83	fatty acid elongation (GO:0030497)	2.53999895
84	rhodopsin mediated signaling pathway (GO:0016056)	2.53203647
85	adenosine metabolic process (GO:0046085)	2.52624574
86	GPI anchor metabolic process (GO:0006505)	2.51266308
87	resolution of meiotic recombination intermediates (GO:0000712)	2.50636649
88	reciprocal DNA recombination (GO:0035825)	2.50157821
89	reciprocal meiotic recombination (GO:0007131)	2.50157821
90	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.49661009
91	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.49029763
92	regulation of neurotransmitter uptake (GO:0051580)	2.48771331
93	pyrimidine nucleobase catabolic process (GO:0006208)	2.48456366
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.48322398
95	embryonic epithelial tube formation (GO:0001838)	2.47788991
96	somite development (GO:0061053)	2.47431739
97	postsynaptic membrane organization (GO:0001941)	2.46855937
98	limb bud formation (GO:0060174)	2.45963637
99	peptidyl-histidine modification (GO:0018202)	2.45939367
100	intraciliary transport (GO:0042073)	2.45856641

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.05462188
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.12744994
3	VDR_22108803_ChIP-Seq_LS180_Human	3.10044310
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67995108
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65231979
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.63524242
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57493740
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47780655
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.41931873
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.40329462
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31218172
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.26611020
13	FUS_26573619_Chip-Seq_HEK293_Human	2.18307267
14	P300_19829295_ChIP-Seq_ESCs_Human	2.16391433
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.11551644
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.09065655
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.08086901
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.04757609
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04577746
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99207664
21	EWS_26573619_Chip-Seq_HEK293_Human	1.97456293
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.85055127
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80203995
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.74485101
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74485101
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72435502
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71720863
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.70923799
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.69745574
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66962049
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64370866
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.63085332
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58822631
34	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.58367496
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57627130
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56597255
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.55336475
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53214777
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52808637
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51564074
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.51507220
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.51507220
43	AR_25329375_ChIP-Seq_VCAP_Human	1.45324264
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42219305
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40685746
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40253341
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38529165
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38137443
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.37369887
50	STAT3_23295773_ChIP-Seq_U87_Human	1.37280059
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37228144
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36944161
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.36284739
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35752091
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32888523
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31161044
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30449880
58	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30413376
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.28209832
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26109655
61	TCF4_23295773_ChIP-Seq_U87_Human	1.25985244
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23506071
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22399645
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21927690
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21895935
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21895935
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21609283
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20681066
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20346637
70	NCOR_22424771_ChIP-Seq_293T_Human	1.20090961
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.19258957
72	AR_20517297_ChIP-Seq_VCAP_Human	1.19002718
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17332193
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17332193
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15663155
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13633824
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12957832
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11569480
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10998494
80	CDX2_22108803_ChIP-Seq_LS180_Human	1.10900817
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10494485
82	VDR_23849224_ChIP-Seq_CD4+_Human	1.07452492
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06921795
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06737133
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03545430
86	JUN_21703547_ChIP-Seq_K562_Human	1.02369942
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02217003
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02128242
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01499290
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01339143
91	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98866367
92	REST_21632747_ChIP-Seq_MESCs_Mouse	0.97413120
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96691878
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96564112
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96434101
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96229054
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95522891
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95380459
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95259131
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94147847

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.39717818
2	MP0002102_abnormal_ear_morphology	2.85389712
3	MP0005551_abnormal_eye_electrophysiolog	2.54700674
4	MP0001968_abnormal_touch/_nociception	2.53420196
5	MP0006072_abnormal_retinal_apoptosis	2.42457101
6	MP0006276_abnormal_autonomic_nervous	2.41518945
7	MP0003195_calcinosis	2.27318532
8	MP0002234_abnormal_pharynx_morphology	2.25655908
9	MP0005645_abnormal_hypothalamus_physiol	2.14959328
10	MP0005253_abnormal_eye_physiology	2.12732304
11	MP0002876_abnormal_thyroid_physiology	2.01644148
12	MP0002736_abnormal_nociception_after	2.00627848
13	MP0002837_dystrophic_cardiac_calcinosis	2.00607775
14	MP0003646_muscle_fatigue	1.95191296
15	MP0005167_abnormal_blood-brain_barrier	1.90599322
16	MP0001529_abnormal_vocalization	1.85439504
17	MP0005503_abnormal_tendon_morphology	1.84318231
18	MP0003011_delayed_dark_adaptation	1.83450809
19	MP0003136_yellow_coat_color	1.77710638
20	MP0005410_abnormal_fertilization	1.75788930
21	MP0000372_irregular_coat_pigmentation	1.75723815
22	MP0001501_abnormal_sleep_pattern	1.74432297
23	MP0001984_abnormal_olfaction	1.73105174
24	MP0005646_abnormal_pituitary_gland	1.70759820
25	MP0008877_abnormal_DNA_methylation	1.70665675
26	MP0009046_muscle_twitch	1.64814017
27	MP0005084_abnormal_gallbladder_morpholo	1.64444196
28	MP0008872_abnormal_physiological_respon	1.60957514
29	MP0002638_abnormal_pupillary_reflex	1.60328664
30	MP0009745_abnormal_behavioral_response	1.57197186
31	MP0004885_abnormal_endolymph	1.52833691
32	MP0002751_abnormal_autonomic_nervous	1.49353640
33	MP0003718_maternal_effect	1.48151330
34	MP0005187_abnormal_penis_morphology	1.47124501
35	MP0002272_abnormal_nervous_system	1.41122349
36	MP0001986_abnormal_taste_sensitivity	1.40387871
37	MP0002163_abnormal_gland_morphology	1.39649670
38	MP0004043_abnormal_pH_regulation	1.39380950
39	MP0000427_abnormal_hair_cycle	1.38554669
40	MP0004133_heterotaxia	1.37509273
41	MP0002733_abnormal_thermal_nociception	1.36383258
42	MP0004142_abnormal_muscle_tone	1.35571574
43	MP0008058_abnormal_DNA_repair	1.35422849
44	MP0002938_white_spotting	1.33776351
45	MP0008875_abnormal_xenobiotic_pharmacok	1.30875718
46	MP0008775_abnormal_heart_ventricle	1.30082945
47	MP0001486_abnormal_startle_reflex	1.29570141
48	MP0000049_abnormal_middle_ear	1.25392709
49	MP0001919_abnormal_reproductive_system	1.21170655
50	MP0000631_abnormal_neuroendocrine_gland	1.18514944
51	MP0000647_abnormal_sebaceous_gland	1.18323955
52	MP0002282_abnormal_trachea_morphology	1.17751652
53	MP0001970_abnormal_pain_threshold	1.15523020
54	MP0002160_abnormal_reproductive_system	1.14710923
55	MP0005195_abnormal_posterior_eye	1.13818247
56	MP0002557_abnormal_social/conspecific_i	1.12922668
57	MP0002735_abnormal_chemical_nociception	1.12677654
58	MP0002254_reproductive_system_inflammat	1.10354022
59	MP0005389_reproductive_system_phenotype	1.07187402
60	MP0002653_abnormal_ependyma_morphology	1.07103192
61	MP0004147_increased_porphyrin_level	1.06839543
62	MP0002572_abnormal_emotion/affect_behav	1.06610917
63	MP0001485_abnormal_pinna_reflex	1.06099201
64	MP0002752_abnormal_somatic_nervous	1.05945736
65	MP0005379_endocrine/exocrine_gland_phen	1.05303193
66	MP0001764_abnormal_homeostasis	1.05069990
67	MP0002928_abnormal_bile_duct	1.03979264
68	MP0000778_abnormal_nervous_system	1.02826347
69	MP0004742_abnormal_vestibular_system	1.02633896
70	MP0004215_abnormal_myocardial_fiber	1.02585811
71	MP0006292_abnormal_olfactory_placode	1.02569397
72	MP0009780_abnormal_chondrocyte_physiolo	1.00962470
73	MP0003698_abnormal_male_reproductive	1.00222136
74	MP0002138_abnormal_hepatobiliary_system	1.00119701
75	MP0010030_abnormal_orbit_morphology	0.97896500
76	MP0008789_abnormal_olfactory_epithelium	0.97542458
77	MP0004085_abnormal_heartbeat	0.94162293
78	MP0003806_abnormal_nucleotide_metabolis	0.92952650
79	MP0000516_abnormal_urinary_system	0.87440584
80	MP0005367_renal/urinary_system_phenotyp	0.87440584
81	MP0002184_abnormal_innervation	0.86684276
82	MP0003119_abnormal_digestive_system	0.86582928
83	MP0001929_abnormal_gametogenesis	0.85279770
84	MP0000026_abnormal_inner_ear	0.84563186
85	MP0001963_abnormal_hearing_physiology	0.83701522
86	MP0003937_abnormal_limbs/digits/tail_de	0.82947516
87	MP0001270_distended_abdomen	0.82733097
88	MP0003137_abnormal_impulse_conducting	0.81786892
89	MP0005391_vision/eye_phenotype	0.80876172
90	MP0000230_abnormal_systemic_arterial	0.80139447
91	MP0009697_abnormal_copulation	0.79678498
92	MP0003950_abnormal_plasma_membrane	0.78206093
93	MP0005360_urolithiasis	0.77367177
94	MP0002909_abnormal_adrenal_gland	0.76215172
95	MP0002210_abnormal_sex_determination	0.75851294
96	MP0005332_abnormal_amino_acid	0.75050530
97	MP0001905_abnormal_dopamine_level	0.74835279
98	MP0003283_abnormal_digestive_organ	0.74652453
99	MP0002734_abnormal_mechanical_nocicepti	0.74609906
100	MP0003787_abnormal_imprinting	0.72913483

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.06699461
2	Abnormality of midbrain morphology (HP:0002418)	4.06699461
3	Pancreatic cysts (HP:0001737)	4.01835864
4	Congenital stationary night blindness (HP:0007642)	3.90671246
5	True hermaphroditism (HP:0010459)	3.78665318
6	Pancreatic fibrosis (HP:0100732)	3.69752083
7	Nephronophthisis (HP:0000090)	3.52581294
8	Medial flaring of the eyebrow (HP:0010747)	3.13617729
9	Abnormality of the renal medulla (HP:0100957)	2.99369659
10	Thyroid-stimulating hormone excess (HP:0002925)	2.99082064
11	Abnormality of the renal cortex (HP:0011035)	2.95542737
12	Attenuation of retinal blood vessels (HP:0007843)	2.95000641
13	Chronic hepatic failure (HP:0100626)	2.83986155
14	Type II lissencephaly (HP:0007260)	2.82895195
15	Abnormal drinking behavior (HP:0030082)	2.79769218
16	Polydipsia (HP:0001959)	2.79769218
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.77386655
18	Tubular atrophy (HP:0000092)	2.72500797
19	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.72364215
20	Hypoplasia of the fovea (HP:0007750)	2.72364215
21	3-Methylglutaconic aciduria (HP:0003535)	2.68802128
22	Nephrogenic diabetes insipidus (HP:0009806)	2.66522567
23	Keratoconus (HP:0000563)	2.62407073
24	Increased corneal curvature (HP:0100692)	2.62407073
25	Lissencephaly (HP:0001339)	2.60782684
26	Pendular nystagmus (HP:0012043)	2.57596893
27	Bilateral microphthalmos (HP:0007633)	2.57283166
28	Progressive inability to walk (HP:0002505)	2.56072593
29	Acute necrotizing encephalopathy (HP:0006965)	2.54187051
30	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.53886373
31	Polyuria (HP:0000103)	2.51976386
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.50916078
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.48398203
34	Congenital primary aphakia (HP:0007707)	2.45521571
35	Abolished electroretinogram (ERG) (HP:0000550)	2.43425847
36	Gait imbalance (HP:0002141)	2.41547229
37	Intestinal atresia (HP:0011100)	2.40517624
38	Acute encephalopathy (HP:0006846)	2.40032746
39	Optic nerve hypoplasia (HP:0000609)	2.39328435
40	Inability to walk (HP:0002540)	2.38467492
41	Disproportionate short-trunk short stature (HP:0003521)	2.38342039
42	Cystic liver disease (HP:0006706)	2.36812308
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36429349
44	Hypothermia (HP:0002045)	2.34191445
45	Progressive macrocephaly (HP:0004481)	2.33184124
46	Mitochondrial inheritance (HP:0001427)	2.30294898
47	Cerebellar dysplasia (HP:0007033)	2.29835920
48	Sclerocornea (HP:0000647)	2.26152014
49	Optic disc pallor (HP:0000543)	2.26114187
50	Decreased circulating renin level (HP:0003351)	2.25183956
51	Short tibia (HP:0005736)	2.23537881
52	Abnormality of the fovea (HP:0000493)	2.22878795
53	Bony spicule pigmentary retinopathy (HP:0007737)	2.18832043
54	Hepatocellular necrosis (HP:0001404)	2.15933170
55	Increased CSF lactate (HP:0002490)	2.14764882
56	Genital tract atresia (HP:0001827)	2.14160326
57	Gaze-evoked nystagmus (HP:0000640)	2.10436151
58	Vaginal atresia (HP:0000148)	2.07762363
59	Renal cortical cysts (HP:0000803)	2.05726243
60	Unilateral renal agenesis (HP:0000122)	2.05222914
61	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04849175
62	Anencephaly (HP:0002323)	2.03969000
63	Congenital hepatic fibrosis (HP:0002612)	2.03343201
64	Abnormal biliary tract physiology (HP:0012439)	2.02928531
65	Bile duct proliferation (HP:0001408)	2.02928531
66	Hyperglycinuria (HP:0003108)	2.02652320
67	Methylmalonic aciduria (HP:0012120)	2.00882849
68	Hepatic necrosis (HP:0002605)	1.99908454
69	Abnormal urine output (HP:0012590)	1.99797421
70	Large for gestational age (HP:0001520)	1.99046962
71	Hyperventilation (HP:0002883)	1.97207496
72	Hypoproteinemia (HP:0003075)	1.97146013
73	Stomach cancer (HP:0012126)	1.95803032
74	Hyperglycinemia (HP:0002154)	1.94887605
75	Delayed CNS myelination (HP:0002188)	1.94556897
76	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93762386
77	Abnormal protein N-linked glycosylation (HP:0012347)	1.93762386
78	Abnormal protein glycosylation (HP:0012346)	1.93762386
79	Abnormal glycosylation (HP:0012345)	1.93762386
80	Concave nail (HP:0001598)	1.93726480
81	Postaxial foot polydactyly (HP:0001830)	1.93448816
82	Occipital encephalocele (HP:0002085)	1.92501078
83	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91509997
84	Decreased central vision (HP:0007663)	1.91130485
85	Methylmalonic acidemia (HP:0002912)	1.89712421
86	Abnormality of macular pigmentation (HP:0008002)	1.89491762
87	Febrile seizures (HP:0002373)	1.89437596
88	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.84093360
89	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83420685
90	Severe muscular hypotonia (HP:0006829)	1.83028506
91	Postaxial hand polydactyly (HP:0001162)	1.81054414
92	Bifid tongue (HP:0010297)	1.80768407
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.80397493
94	Abnormality of glycine metabolism (HP:0010895)	1.80397493
95	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.80311161
96	Abnormality of the labia minora (HP:0012880)	1.80126368
97	Male pseudohermaphroditism (HP:0000037)	1.74839311
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.72033049
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.72033049
100	Narrow forehead (HP:0000341)	1.71698448

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.71040402
2	ADRBK2	3.73233890
3	MAP4K2	2.66599644
4	WNK3	2.64196849
5	TRIM28	2.62869651
6	MAP3K4	2.51564713
7	TLK1	2.42137262
8	BMPR1B	2.34582258
9	ZAK	2.21628782
10	GRK1	2.14281788
11	BCR	2.11689589
12	CASK	1.96547536
13	PLK2	1.86670102
14	PINK1	1.82323681
15	TAOK3	1.81625164
16	MAP2K7	1.75347364
17	NUAK1	1.72385535
18	ERBB3	1.58219030
19	OXSR1	1.53083588
20	MAPK13	1.52917686
21	EPHA4	1.52780637
22	MAP3K12	1.42904319
23	BMPR2	1.40079481
24	STK16	1.39925089
25	BCKDK	1.39841437
26	FLT3	1.34092370
27	PRKCE	1.32960665
28	WNK4	1.27104836
29	ADRBK1	1.25810837
30	ACVR1B	1.25770610
31	INSRR	1.20428562
32	TNIK	1.18323411
33	CSNK1G3	1.17720166
34	TIE1	1.15617087
35	CSNK1A1L	1.15131665
36	CSNK1G1	1.14593435
37	PAK3	1.11952196
38	STK38L	1.11877804
39	LIMK1	1.09615902
40	GRK5	1.08136026
41	MKNK2	1.07548755
42	MKNK1	1.06208575
43	CSNK1G2	1.04748500
44	DYRK2	1.02459725
45	PRKCG	0.99392123
46	MAPKAPK3	0.97267381
47	SRPK1	0.97002702
48	MARK1	0.96618462
49	TXK	0.95591300
50	CDK19	0.92967290
51	FGFR2	0.87162718
52	STK39	0.86738552
53	FER	0.85137266
54	TGFBR1	0.85127948
55	PLK3	0.83673828
56	DAPK2	0.80890699
57	NME1	0.80441783
58	MST4	0.79612670
59	VRK1	0.78082784
60	EPHA3	0.76319601
61	PTK2B	0.71898354
62	BRSK2	0.71625424
63	MAPKAPK5	0.70775126
64	PLK4	0.70409430
65	VRK2	0.68566459
66	CAMK2A	0.68334240
67	GRK7	0.66962205
68	PAK6	0.61297943
69	MUSK	0.61277284
70	TGFBR2	0.60321252
71	CAMKK2	0.58813586
72	AKT3	0.57955449
73	PHKG1	0.55256858
74	PHKG2	0.55256858
75	DAPK1	0.51182683
76	MAP2K6	0.50746747
77	DYRK3	0.50458067
78	EPHB2	0.50422467
79	MYLK	0.49787037
80	PRKCI	0.48860792
81	CSNK1A1	0.47789370
82	MAP2K4	0.44834159
83	TEC	0.44760091
84	TSSK6	0.44423365
85	ERBB2	0.42578609
86	MARK3	0.40153861
87	SIK3	0.40126664
88	SIK2	0.40060211
89	PRKACA	0.38834736
90	CAMK1	0.37826082
91	STK3	0.37563560
92	EIF2AK3	0.36393166
93	PIK3CA	0.35249410
94	PNCK	0.35087711
95	NEK2	0.34671750
96	PLK1	0.34233440
97	PRKCA	0.31609415
98	RPS6KA5	0.31199094
99	CSNK1D	0.31187130
100	IGF1R	0.30748396

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.04662056
2	Phototransduction_Homo sapiens_hsa04744	2.90386701
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68340862
4	Protein export_Homo sapiens_hsa03060	2.63967413
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.39210991
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25666991
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24272472
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.24239260
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.20461276
10	Butanoate metabolism_Homo sapiens_hsa00650	2.07365521
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.06980365
12	Parkinsons disease_Homo sapiens_hsa05012	1.88720128
13	RNA polymerase_Homo sapiens_hsa03020	1.88488930
14	Propanoate metabolism_Homo sapiens_hsa00640	1.88213193
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77314059
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74635165
17	Olfactory transduction_Homo sapiens_hsa04740	1.74061522
18	Proteasome_Homo sapiens_hsa03050	1.67901963
19	Nicotine addiction_Homo sapiens_hsa05033	1.66705222
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.63807891
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.59659916
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55294076
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.50639918
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.48825944
25	Regulation of autophagy_Homo sapiens_hsa04140	1.45390812
26	Homologous recombination_Homo sapiens_hsa03440	1.44151302
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.38657030
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38479638
29	Basal transcription factors_Homo sapiens_hsa03022	1.37199613
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.35977382
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34409487
32	Huntingtons disease_Homo sapiens_hsa05016	1.32524664
33	Morphine addiction_Homo sapiens_hsa05032	1.31903625
34	Fatty acid elongation_Homo sapiens_hsa00062	1.31395259
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27738852
36	Taste transduction_Homo sapiens_hsa04742	1.27690704
37	Peroxisome_Homo sapiens_hsa04146	1.27585474
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23690795
39	Alzheimers disease_Homo sapiens_hsa05010	1.22726520
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.18423867
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18270402
42	Retinol metabolism_Homo sapiens_hsa00830	1.17903417
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17826417
44	GABAergic synapse_Homo sapiens_hsa04727	1.15986751
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08623631
46	Caffeine metabolism_Homo sapiens_hsa00232	1.04438167
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03026587
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.01458313
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.00269808
50	Sulfur metabolism_Homo sapiens_hsa00920	0.99724072
51	RNA degradation_Homo sapiens_hsa03018	0.99580405
52	Purine metabolism_Homo sapiens_hsa00230	0.92937872
53	Circadian rhythm_Homo sapiens_hsa04710	0.91892304
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89525091
55	Serotonergic synapse_Homo sapiens_hsa04726	0.88648513
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88225158
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87634367
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.87069166
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.82322516
60	Circadian entrainment_Homo sapiens_hsa04713	0.80477401
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78159741
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77505413
63	Metabolic pathways_Homo sapiens_hsa01100	0.76724538
64	Mineral absorption_Homo sapiens_hsa04978	0.76317110
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73425514
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72617426
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72002057
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69205046
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68603541
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67633729
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63894763
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63699379
73	Salivary secretion_Homo sapiens_hsa04970	0.62892710
74	ABC transporters_Homo sapiens_hsa02010	0.62125884
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.61493455
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60060251
77	Glutathione metabolism_Homo sapiens_hsa00480	0.58456737
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57142407
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.56262934
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53971449
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53203894
82	One carbon pool by folate_Homo sapiens_hsa00670	0.52745372
83	Insulin secretion_Homo sapiens_hsa04911	0.50940533
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.50914125
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.50597637
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50295276
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49471193
88	Mismatch repair_Homo sapiens_hsa03430	0.49451037
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49231139
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47971818
91	Nucleotide excision repair_Homo sapiens_hsa03420	0.45221306
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45134163
93	Fatty acid degradation_Homo sapiens_hsa00071	0.44640757
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44190781
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.41870352
96	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40462852
97	Long-term depression_Homo sapiens_hsa04730	0.36469175
98	Base excision repair_Homo sapiens_hsa03410	0.35578802
99	Histidine metabolism_Homo sapiens_hsa00340	0.33094034
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.28770210

WTAPP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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