ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.74481248
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.50601578
3	positive regulation of gastrulation (GO:2000543)	4.44340448
4	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.38908431
5	neurofilament cytoskeleton organization (GO:0060052)	4.14552559
6	neuron cell-cell adhesion (GO:0007158)	4.01999344
7	gamma-aminobutyric acid transport (GO:0015812)	3.96877103
8	neuron fate specification (GO:0048665)	3.94457729
9	regulation of meiosis I (GO:0060631)	3.91306005
10	piRNA metabolic process (GO:0034587)	3.90302944
11	retinal cone cell development (GO:0046549)	3.83120802
12	nucleobase catabolic process (GO:0046113)	3.73466911
13	neurotransmitter-gated ion channel clustering (GO:0072578)	3.55211982
14	protein localization to cilium (GO:0061512)	3.54283482
15	multicellular organism reproduction (GO:0032504)	3.51225204
16	regulation of acrosome reaction (GO:0060046)	3.45847613
17	DNA methylation involved in gamete generation (GO:0043046)	3.40852196
18	behavioral response to ethanol (GO:0048149)	3.40447564
19	epithelial cilium movement (GO:0003351)	3.37725825
20	somite rostral/caudal axis specification (GO:0032525)	3.33021301
21	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.28456807
22	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.26644673
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.26069221
24	neuron fate determination (GO:0048664)	3.22991782
25	sulfation (GO:0051923)	3.20103864
26	base-excision repair, AP site formation (GO:0006285)	3.17226267
27	regulation of female gonad development (GO:2000194)	3.12978688
28	protein neddylation (GO:0045116)	3.10778078
29	postsynaptic membrane organization (GO:0001941)	3.10527409
30	axonal fasciculation (GO:0007413)	3.10173724
31	synaptic vesicle maturation (GO:0016188)	3.09202732
32	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.03832357
33	glutamate receptor signaling pathway (GO:0007215)	3.02624452
34	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.99954034
35	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.99068009
36	synaptic transmission, glutamatergic (GO:0035249)	2.97361976
37	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.96194398
38	positive regulation of amino acid transport (GO:0051957)	2.94427328
39	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.92745785
40	detection of light stimulus involved in sensory perception (GO:0050962)	2.90444429
41	detection of light stimulus involved in visual perception (GO:0050908)	2.90444429
42	vocalization behavior (GO:0071625)	2.87381591
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.85907909
44	ATP synthesis coupled proton transport (GO:0015986)	2.85907909
45	neuronal action potential propagation (GO:0019227)	2.78784370
46	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.78500807
47	synaptic transmission, cholinergic (GO:0007271)	2.78346972
48	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.77703079
49	centriole replication (GO:0007099)	2.77508937
50	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.76808470
51	neuron recognition (GO:0008038)	2.75915786
52	limb development (GO:0060173)	2.75652915
53	appendage development (GO:0048736)	2.75652915
54	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.75238146
55	dopamine biosynthetic process (GO:0042416)	2.73908030
56	neuron-neuron synaptic transmission (GO:0007270)	2.72266645
57	presynaptic membrane assembly (GO:0097105)	2.71957950
58	dendritic spine morphogenesis (GO:0060997)	2.71931748
59	transmission of nerve impulse (GO:0019226)	2.71341297
60	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.69562987
61	protein-cofactor linkage (GO:0018065)	2.68954655
62	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.68205428
63	synapse assembly (GO:0007416)	2.65215769
64	cilium movement (GO:0003341)	2.65099992
65	cornea development in camera-type eye (GO:0061303)	2.63649557
66	acrosome assembly (GO:0001675)	2.61652832
67	neuron maturation (GO:0042551)	2.60522177
68	centriole assembly (GO:0098534)	2.60163978
69	neuronal action potential (GO:0019228)	2.59813120
70	cAMP catabolic process (GO:0006198)	2.59607750
71	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.58015367
72	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.58015367
73	positive regulation of synapse assembly (GO:0051965)	2.57434477
74	regulation of hexokinase activity (GO:1903299)	2.56474326
75	regulation of glucokinase activity (GO:0033131)	2.56474326
76	sequestering of actin monomers (GO:0042989)	2.54751832
77	meiotic cell cycle (GO:0051321)	2.53869521
78	positive regulation of meiosis (GO:0045836)	2.52383893
79	rhodopsin mediated signaling pathway (GO:0016056)	2.50861820
80	neurotransmitter secretion (GO:0007269)	2.50070905
81	kynurenine metabolic process (GO:0070189)	2.47932219
82	forebrain neuron differentiation (GO:0021879)	2.47916349
83	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.47231056
84	regulation of synaptic transmission, GABAergic (GO:0032228)	2.47132539
85	protein localization to synapse (GO:0035418)	2.46852815
86	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.46073038
87	spinal cord motor neuron differentiation (GO:0021522)	2.44662687
88	primitive streak formation (GO:0090009)	2.43342345
89	fucose catabolic process (GO:0019317)	2.43010906
90	L-fucose metabolic process (GO:0042354)	2.43010906
91	L-fucose catabolic process (GO:0042355)	2.43010906
92	protein complex biogenesis (GO:0070271)	2.42321958
93	protein deneddylation (GO:0000338)	2.41826373
94	photoreceptor cell development (GO:0042461)	2.41796828
95	retinal ganglion cell axon guidance (GO:0031290)	2.40320418
96	cullin deneddylation (GO:0010388)	2.40104685
97	platelet dense granule organization (GO:0060155)	2.38710406
98	limb bud formation (GO:0060174)	2.38532655
99	glycine transport (GO:0015816)	2.38351007
100	magnesium ion transport (GO:0015693)	2.36825633

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.64511216
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.07812838
3	TAF15_26573619_Chip-Seq_HEK293_Human	3.03080033
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.94830562
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79074962
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.70078701
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69290285
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55797255
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42662569
10	VDR_22108803_ChIP-Seq_LS180_Human	2.38246575
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.37464654
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22239979
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.20556141
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20447110
15	FUS_26573619_Chip-Seq_HEK293_Human	2.18021328
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.17448477
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10913674
18	EWS_26573619_Chip-Seq_HEK293_Human	2.06634330
19	RNF2_27304074_Chip-Seq_NSC_Mouse	1.90868582
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.90316029
21	P300_19829295_ChIP-Seq_ESCs_Human	1.85936068
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84233502
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.80255654
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.76686426
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72288254
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71554430
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.70289524
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.69739155
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69597681
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.69083290
31	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.65668218
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59493765
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.58867474
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55541863
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51116641
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49442392
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48913560
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.48551683
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46337344
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46045410
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.44755135
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44755135
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41549361
44	HTT_18923047_ChIP-ChIP_STHdh_Human	1.41485013
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41383739
46	AR_25329375_ChIP-Seq_VCAP_Human	1.41025760
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39843931
48	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.39359451
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38779966
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38550101
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37682581
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37338591
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37335267
54	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36204323
55	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.34561623
56	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.34481558
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.34363041
58	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33358824
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33240207
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.33009674
61	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27357793
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25733648
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25733648
64	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.23769247
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22229845
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.21242622
67	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.21000113
68	STAT3_23295773_ChIP-Seq_U87_Human	1.20663333
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.18730544
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18502883
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18338032
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18338032
73	TCF4_23295773_ChIP-Seq_U87_Human	1.17268619
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16542594
75	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.16174752
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14311945
77	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.13530647
78	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.13530647
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.12225381
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12146425
81	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.11794947
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11347497
83	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.11198494
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11080797
85	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.08596382
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07577812
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06637686
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.05869741
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04828975
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03932123
91	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.03513979
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02952308
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02145394
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02145394
95	AR_21572438_ChIP-Seq_LNCaP_Human	1.02050081
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01683232
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98519740
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98447401
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98141905
100	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.97458648

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	2.93668931
2	MP0003121_genomic_imprinting	2.91127480
3	MP0003880_abnormal_central_pattern	2.82277945
4	MP0008877_abnormal_DNA_methylation	2.68078853
5	MP0001529_abnormal_vocalization	2.63023475
6	MP0003787_abnormal_imprinting	2.59800369
7	MP0002102_abnormal_ear_morphology	2.47576689
8	MP0003718_maternal_effect	2.40895442
9	MP0006292_abnormal_olfactory_placode	2.39705390
10	MP0004133_heterotaxia	2.32899214
11	MP0003890_abnormal_embryonic-extraembry	2.32818657
12	MP0004270_analgesia	2.31236122
13	MP0002272_abnormal_nervous_system	2.29225369
14	MP0006276_abnormal_autonomic_nervous	2.24372185
15	MP0005646_abnormal_pituitary_gland	2.21416529
16	MP0005645_abnormal_hypothalamus_physiol	2.19376829
17	MP0009745_abnormal_behavioral_response	2.10788417
18	MP0002822_catalepsy	2.10358319
19	MP0002735_abnormal_chemical_nociception	2.03679612
20	MP0003635_abnormal_synaptic_transmissio	2.02465588
21	MP0004859_abnormal_synaptic_plasticity	1.98128995
22	MP0008789_abnormal_olfactory_epithelium	1.96161546
23	MP0005423_abnormal_somatic_nervous	1.95706207
24	MP0001968_abnormal_touch/_nociception	1.92374520
25	MP0000631_abnormal_neuroendocrine_gland	1.86629935
26	MP0001501_abnormal_sleep_pattern	1.86013196
27	MP0005551_abnormal_eye_electrophysiolog	1.84312925
28	MP0004142_abnormal_muscle_tone	1.80758325
29	MP0005394_taste/olfaction_phenotype	1.76392105
30	MP0005499_abnormal_olfactory_system	1.76392105
31	MP0002557_abnormal_social/conspecific_i	1.68862870
32	MP0001984_abnormal_olfaction	1.67402665
33	MP0002572_abnormal_emotion/affect_behav	1.67100124
34	MP0002736_abnormal_nociception_after	1.66549416
35	MP0006072_abnormal_retinal_apoptosis	1.59703224
36	MP0008995_early_reproductive_senescence	1.58289938
37	MP0002734_abnormal_mechanical_nocicepti	1.57795174
38	MP0002064_seizures	1.56849919
39	MP0001486_abnormal_startle_reflex	1.55433274
40	MP0002063_abnormal_learning/memory/cond	1.54637870
41	MP0002638_abnormal_pupillary_reflex	1.51048005
42	MP0005386_behavior/neurological_phenoty	1.46945104
43	MP0004924_abnormal_behavior	1.46945104
44	MP0002733_abnormal_thermal_nociception	1.44125088
45	MP0000778_abnormal_nervous_system	1.43255645
46	MP0009046_muscle_twitch	1.40721044
47	MP0002277_abnormal_respiratory_mucosa	1.39888410
48	MP0002184_abnormal_innervation	1.37650345
49	MP0002067_abnormal_sensory_capabilities	1.37547104
50	MP0001970_abnormal_pain_threshold	1.36580745
51	MP0010386_abnormal_urinary_bladder	1.35548085
52	MP0001485_abnormal_pinna_reflex	1.28838426
53	MP0002234_abnormal_pharynx_morphology	1.19916145
54	MP0005253_abnormal_eye_physiology	1.19669256
55	MP0004885_abnormal_endolymph	1.17773809
56	MP0000049_abnormal_middle_ear	1.15923003
57	MP0001986_abnormal_taste_sensitivity	1.15245871
58	MP0002882_abnormal_neuron_morphology	1.12187570
59	MP0002160_abnormal_reproductive_system	1.11577248
60	MP0003195_calcinosis	1.08543643
61	MP0008875_abnormal_xenobiotic_pharmacok	1.08219190
62	MP0001440_abnormal_grooming_behavior	1.07608364
63	MP0002876_abnormal_thyroid_physiology	1.07234363
64	MP0000566_synostosis	1.05506952
65	MP0002928_abnormal_bile_duct	1.05276870
66	MP0000955_abnormal_spinal_cord	1.03721203
67	MP0002909_abnormal_adrenal_gland	1.01962319
68	MP0002751_abnormal_autonomic_nervous	1.01521090
69	MP0002138_abnormal_hepatobiliary_system	1.00096918
70	MP0000427_abnormal_hair_cycle	0.98575285
71	MP0002752_abnormal_somatic_nervous	0.96773682
72	MP0001502_abnormal_circadian_rhythm	0.96641119
73	MP0004742_abnormal_vestibular_system	0.96335812
74	MP0005084_abnormal_gallbladder_morpholo	0.94568196
75	MP0001905_abnormal_dopamine_level	0.91800795
76	MP0005187_abnormal_penis_morphology	0.90702733
77	MP0002837_dystrophic_cardiac_calcinosis	0.89482349
78	MP0001293_anophthalmia	0.88488675
79	MP0000026_abnormal_inner_ear	0.87281986
80	MP0003119_abnormal_digestive_system	0.86012596
81	MP0002210_abnormal_sex_determination	0.84973973
82	MP0003879_abnormal_hair_cell	0.84682968
83	MP0005389_reproductive_system_phenotype	0.83870987
84	MP0005410_abnormal_fertilization	0.83315432
85	MP0003646_muscle_fatigue	0.83284876
86	MP0002139_abnormal_hepatobiliary_system	0.82626422
87	MP0004043_abnormal_pH_regulation	0.82442516
88	MP0002229_neurodegeneration	0.82293223
89	MP0001929_abnormal_gametogenesis	0.82126563
90	MP0003011_delayed_dark_adaptation	0.81819202
91	MP0005085_abnormal_gallbladder_physiolo	0.81383890
92	MP0004811_abnormal_neuron_physiology	0.80949130
93	MP0003698_abnormal_male_reproductive	0.80714956
94	MP0001324_abnormal_eye_pigmentation	0.80560525
95	MP0002066_abnormal_motor_capabilities/c	0.78751488
96	MP0002069_abnormal_eating/drinking_beha	0.78133643
97	MP0005195_abnormal_posterior_eye	0.78071749
98	MP0000653_abnormal_sex_gland	0.76853813
99	MP0003283_abnormal_digestive_organ	0.76307240
100	MP0005647_abnormal_sex_gland	0.76057746

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligodactyly (hands) (HP:0001180)	3.63685660
2	Medial flaring of the eyebrow (HP:0010747)	3.48401343
3	3-Methylglutaconic aciduria (HP:0003535)	3.28413406
4	Pancreatic cysts (HP:0001737)	3.27452096
5	Gait imbalance (HP:0002141)	3.21478184
6	Polyphagia (HP:0002591)	3.13538756
7	Focal motor seizures (HP:0011153)	3.04443219
8	Pancreatic fibrosis (HP:0100732)	2.99932945
9	Congenital primary aphakia (HP:0007707)	2.93926493
10	Congenital stationary night blindness (HP:0007642)	2.91679973
11	Myokymia (HP:0002411)	2.90891365
12	Nephrogenic diabetes insipidus (HP:0009806)	2.90016741
13	Nephronophthisis (HP:0000090)	2.80475600
14	Volvulus (HP:0002580)	2.79630769
15	Abnormality of the labia minora (HP:0012880)	2.73202467
16	True hermaphroditism (HP:0010459)	2.72809074
17	Abnormal ciliary motility (HP:0012262)	2.71312092
18	Genital tract atresia (HP:0001827)	2.64328261
19	Molar tooth sign on MRI (HP:0002419)	2.64187296
20	Abnormality of midbrain morphology (HP:0002418)	2.64187296
21	Limb dystonia (HP:0002451)	2.55592621
22	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.52215366
23	Hypoplasia of the fovea (HP:0007750)	2.52215366
24	Focal seizures (HP:0007359)	2.51800391
25	Febrile seizures (HP:0002373)	2.51218128
26	Vaginal atresia (HP:0000148)	2.50712075
27	Abnormal respiratory motile cilium physiology (HP:0012261)	2.48503272
28	Hyperglycinemia (HP:0002154)	2.47820558
29	Progressive cerebellar ataxia (HP:0002073)	2.45568971
30	Attenuation of retinal blood vessels (HP:0007843)	2.43553944
31	Supernumerary spleens (HP:0009799)	2.42743905
32	Drooling (HP:0002307)	2.40464053
33	Abnormal eating behavior (HP:0100738)	2.39570111
34	Anterior segment dysgenesis (HP:0007700)	2.39149484
35	Lissencephaly (HP:0001339)	2.32979786
36	Limb hypertonia (HP:0002509)	2.31328091
37	Abnormality of the renal medulla (HP:0100957)	2.31326335
38	Oligodactyly (HP:0012165)	2.28731971
39	Inability to walk (HP:0002540)	2.26983235
40	Chronic hepatic failure (HP:0100626)	2.23764242
41	Abnormality of the fovea (HP:0000493)	2.22931070
42	Anencephaly (HP:0002323)	2.22758486
43	Optic nerve hypoplasia (HP:0000609)	2.22563819
44	Septo-optic dysplasia (HP:0100842)	2.20933341
45	Renal cortical cysts (HP:0000803)	2.20260382
46	Abnormality of the renal cortex (HP:0011035)	2.19806050
47	Sclerocornea (HP:0000647)	2.18113007
48	Pachygyria (HP:0001302)	2.17369337
49	Excessive salivation (HP:0003781)	2.16285364
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13332973
51	Hypsarrhythmia (HP:0002521)	2.10303942
52	Abolished electroretinogram (ERG) (HP:0000550)	2.10056334
53	Broad-based gait (HP:0002136)	2.08110405
54	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.07837902
55	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.07837902
56	Generalized tonic-clonic seizures (HP:0002069)	2.07714397
57	Hypothermia (HP:0002045)	2.07634933
58	Hyperventilation (HP:0002883)	2.07254222
59	Pendular nystagmus (HP:0012043)	2.07144166
60	Intestinal atresia (HP:0011100)	2.04509872
61	EEG with generalized epileptiform discharges (HP:0011198)	2.03937216
62	Rhinitis (HP:0012384)	2.03908848
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03665830
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03665830
65	Cystic liver disease (HP:0006706)	2.01346850
66	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.00784715
67	Epileptiform EEG discharges (HP:0011182)	2.00640472
68	Spastic tetraplegia (HP:0002510)	2.00594455
69	Abnormal respiratory epithelium morphology (HP:0012253)	2.00373650
70	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00373650
71	Abnormal mitochondria in muscle tissue (HP:0008316)	1.99370739
72	Atonic seizures (HP:0010819)	1.99370049
73	Split foot (HP:0001839)	1.99088288
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97881818
75	Specific learning disability (HP:0001328)	1.97092756
76	Type II lissencephaly (HP:0007260)	1.94909146
77	Congenital, generalized hypertrichosis (HP:0004540)	1.94284404
78	Aplasia/Hypoplasia of the lens (HP:0008063)	1.94108134
79	Optic disc pallor (HP:0000543)	1.92759047
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.92563808
81	Gaze-evoked nystagmus (HP:0000640)	1.92302889
82	Short tibia (HP:0005736)	1.91072003
83	Hemiparesis (HP:0001269)	1.90080829
84	Mutism (HP:0002300)	1.89173022
85	Postaxial foot polydactyly (HP:0001830)	1.88528761
86	Retinal dysplasia (HP:0007973)	1.87576577
87	Thyroid-stimulating hormone excess (HP:0002925)	1.87538877
88	Amyotrophic lateral sclerosis (HP:0007354)	1.87063930
89	Postaxial hand polydactyly (HP:0001162)	1.87040311
90	Acute necrotizing encephalopathy (HP:0006965)	1.86547641
91	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.86215692
92	Methylmalonic acidemia (HP:0002912)	1.83127120
93	Poor coordination (HP:0002370)	1.82422888
94	Acute encephalopathy (HP:0006846)	1.81886244
95	Impaired vibration sensation in the lower limbs (HP:0002166)	1.81831631
96	Dialeptic seizures (HP:0011146)	1.77488931
97	Renal Fanconi syndrome (HP:0001994)	1.76563349
98	Epileptic encephalopathy (HP:0200134)	1.76217905
99	Occipital encephalocele (HP:0002085)	1.74486004
100	Absent septum pellucidum (HP:0001331)	1.73238871

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.67948202
2	WNK3	2.70526577
3	FRK	2.62908387
4	BCR	2.56336143
5	MAPK13	2.54809099
6	CDK19	2.54612932
7	MAP3K4	2.53450284
8	MAP4K2	2.30430760
9	PINK1	2.24201596
10	TAOK3	2.22812699
11	ADRBK2	2.16367980
12	MAP2K7	2.11717761
13	MUSK	1.97360412
14	BMPR1B	1.81527302
15	ERBB3	1.67857454
16	GRK1	1.66238149
17	CASK	1.64941167
18	OXSR1	1.62282146
19	CSNK1G2	1.55937247
20	ZAK	1.55409047
21	DYRK2	1.55324338
22	STK38L	1.52715967
23	TRIM28	1.48643028
24	TXK	1.46785912
25	CSNK1G3	1.44687498
26	NTRK2	1.43581128
27	MINK1	1.41441463
28	DYRK3	1.38483430
29	VRK1	1.29361828
30	PHKG1	1.29110952
31	PHKG2	1.29110952
32	UHMK1	1.24740208
33	PRKCE	1.21725476
34	CAMK2A	1.20465699
35	PRKD3	1.20058794
36	PAK3	1.15602887
37	NTRK3	1.14085168
38	CSNK1A1L	1.12021326
39	ADRBK1	1.11523376
40	EPHA4	1.11497346
41	CSNK1G1	1.10797893
42	PRKCG	1.10114009
43	BCKDK	1.07845111
44	CDK3	1.06346105
45	BUB1	1.03794643
46	TGFBR1	1.00537681
47	STK24	0.98001755
48	PLK2	0.97087440
49	TIE1	0.90557509
50	ACVR1B	0.87845460
51	EPHA3	0.85046007
52	WNK4	0.81157703
53	CDK5	0.80320808
54	PIK3CA	0.78776471
55	PRKACA	0.77203347
56	INSRR	0.77091000
57	PRKCZ	0.71929092
58	NEK6	0.71711657
59	PRKG1	0.71451695
60	MKNK2	0.68345079
61	CAMK2B	0.65690927
62	TAF1	0.65154950
63	NUAK1	0.65094292
64	TLK1	0.64135323
65	AURKA	0.63084724
66	CDK9	0.62512479
67	CSNK1E	0.59971208
68	PKN1	0.59955787
69	STK39	0.59765791
70	CSNK1D	0.54749707
71	CDC7	0.54635884
72	PLK3	0.54371275
73	CDK14	0.51819618
74	DYRK1A	0.51334877
75	PRKACB	0.51269500
76	PRKCA	0.50152700
77	TNIK	0.49411599
78	CSNK1A1	0.47737040
79	CAMKK2	0.46671217
80	DYRK1B	0.45839230
81	KIT	0.45695872
82	PNCK	0.45222148
83	CDK8	0.44997679
84	STK38	0.44991265
85	PRKACG	0.41096357
86	TAOK1	0.40762090
87	CDK18	0.40324265
88	STK11	0.38808253
89	KDR	0.38699674
90	DAPK2	0.38678067
91	CAMK2D	0.38006158
92	EGFR	0.37490601
93	CDK11A	0.36829672
94	CHEK2	0.36555798
95	PRKCI	0.36486651
96	MAPK15	0.35219118
97	CDK15	0.35162912
98	CAMK4	0.34105070
99	RPS6KA4	0.33019402
100	CCNB1	0.31524923

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.80615176
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.23527944
3	Phototransduction_Homo sapiens_hsa04744	2.85491611
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.84548965
5	GABAergic synapse_Homo sapiens_hsa04727	2.45073596
6	Parkinsons disease_Homo sapiens_hsa05012	2.37574841
7	Taste transduction_Homo sapiens_hsa04742	2.12050470
8	Basal transcription factors_Homo sapiens_hsa03022	2.10298498
9	Morphine addiction_Homo sapiens_hsa05032	1.97267621
10	Protein export_Homo sapiens_hsa03060	1.91747848
11	Amphetamine addiction_Homo sapiens_hsa05031	1.84618294
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84040826
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81889108
14	Olfactory transduction_Homo sapiens_hsa04740	1.81518611
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.81326864
16	Caffeine metabolism_Homo sapiens_hsa00232	1.81120605
17	Cocaine addiction_Homo sapiens_hsa05030	1.78953973
18	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.78466863
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.75569256
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.74885862
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.74577999
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.73828740
23	Circadian entrainment_Homo sapiens_hsa04713	1.73120772
24	Alzheimers disease_Homo sapiens_hsa05010	1.64991225
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60443817
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.55525893
27	Butanoate metabolism_Homo sapiens_hsa00650	1.49360020
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.48804485
29	Huntingtons disease_Homo sapiens_hsa05016	1.47981622
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.47960917
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47391596
32	Serotonergic synapse_Homo sapiens_hsa04726	1.41989685
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.32451502
34	Renin secretion_Homo sapiens_hsa04924	1.21824891
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17649441
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.16871931
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.15450721
38	Oocyte meiosis_Homo sapiens_hsa04114	1.13489326
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06814594
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06535761
41	Insulin secretion_Homo sapiens_hsa04911	1.03020196
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01815070
43	Circadian rhythm_Homo sapiens_hsa04710	0.99004750
44	Salivary secretion_Homo sapiens_hsa04970	0.94306584
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90835995
46	Long-term depression_Homo sapiens_hsa04730	0.89581653
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.88329397
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.86944828
49	Calcium signaling pathway_Homo sapiens_hsa04020	0.86306153
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83468480
51	Axon guidance_Homo sapiens_hsa04360	0.80815366
52	RNA degradation_Homo sapiens_hsa03018	0.78819698
53	Cholinergic synapse_Homo sapiens_hsa04725	0.77813878
54	Propanoate metabolism_Homo sapiens_hsa00640	0.77092189
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76960988
56	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.76878929
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74964148
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.74770757
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.74036091
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73910699
61	Regulation of autophagy_Homo sapiens_hsa04140	0.72788389
62	Homologous recombination_Homo sapiens_hsa03440	0.72033901
63	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.68891447
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67363540
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66735210
66	Gap junction_Homo sapiens_hsa04540	0.64499418
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62491791
68	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59787349
69	Gastric acid secretion_Homo sapiens_hsa04971	0.58656901
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58340422
71	Base excision repair_Homo sapiens_hsa03410	0.56953946
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56602980
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56548465
74	ABC transporters_Homo sapiens_hsa02010	0.55765914
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55115117
76	Retinol metabolism_Homo sapiens_hsa00830	0.52370382
77	RNA polymerase_Homo sapiens_hsa03020	0.51614495
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49382668
79	Long-term potentiation_Homo sapiens_hsa04720	0.48771414
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47856627
81	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.47346991
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46850356
83	Vibrio cholerae infection_Homo sapiens_hsa05110	0.46439951
84	Peroxisome_Homo sapiens_hsa04146	0.46419952
85	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44383089
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.43987915
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43571979
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42387938
89	Pancreatic secretion_Homo sapiens_hsa04972	0.42058248
90	Metabolic pathways_Homo sapiens_hsa01100	0.41327943
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36776605
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36648013
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35500092
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35353271
95	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.33109874
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31136238
97	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30607818
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.29528567
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.29509151
100	Alcoholism_Homo sapiens_hsa05034	0.27177257

WTH3DI

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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