WTIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of apical/basal cell polarity (GO:0035089)5.28846817
2behavioral response to nicotine (GO:0035095)4.96963244
3paraxial mesoderm development (GO:0048339)4.85992042
4tryptophan catabolic process (GO:0006569)4.76305968
5indole-containing compound catabolic process (GO:0042436)4.76305968
6indolalkylamine catabolic process (GO:0046218)4.76305968
7* regulation of gene silencing by RNA (GO:0060966)4.74223535
8* regulation of posttranscriptional gene silencing (GO:0060147)4.74223535
9* regulation of gene silencing by miRNA (GO:0060964)4.74223535
10polarized epithelial cell differentiation (GO:0030859)4.65834527
11kynurenine metabolic process (GO:0070189)4.59051696
12indolalkylamine metabolic process (GO:0006586)4.43432819
13establishment or maintenance of monopolar cell polarity (GO:0061339)4.41973626
14establishment of monopolar cell polarity (GO:0061162)4.41973626
15heterochromatin organization (GO:0070828)4.10594957
16positive regulation of SMAD protein import into nucleus (GO:0060391)4.09104350
17tryptophan metabolic process (GO:0006568)3.92554928
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.92446571
19regulation of SMAD protein import into nucleus (GO:0060390)3.86391964
20pre-miRNA processing (GO:0031054)3.76623620
21signal peptide processing (GO:0006465)3.76005737
22cilium or flagellum-dependent cell motility (GO:0001539)3.74213196
23anterior/posterior axis specification, embryo (GO:0008595)3.70622475
24fucose catabolic process (GO:0019317)3.69104008
25L-fucose metabolic process (GO:0042354)3.69104008
26L-fucose catabolic process (GO:0042355)3.69104008
27detection of light stimulus involved in visual perception (GO:0050908)3.61731237
28detection of light stimulus involved in sensory perception (GO:0050962)3.61731237
29notochord development (GO:0030903)3.57147689
30negative regulation of translation, ncRNA-mediated (GO:0040033)3.55912487
31regulation of translation, ncRNA-mediated (GO:0045974)3.55912487
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.55912487
33formation of translation preinitiation complex (GO:0001731)3.55151372
34gamma-aminobutyric acid transport (GO:0015812)3.52508637
35regulation of translational fidelity (GO:0006450)3.43347895
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42810172
37positive regulation of developmental pigmentation (GO:0048087)3.38409939
38regulation of pigment cell differentiation (GO:0050932)3.38345524
39protein localization to kinetochore (GO:0034501)3.38106899
40hippo signaling (GO:0035329)3.37124006
41indole-containing compound metabolic process (GO:0042430)3.37053518
42* regulation of hippo signaling (GO:0035330)3.35531929
43reflex (GO:0060004)3.29478865
44basement membrane organization (GO:0071711)3.28797426
45planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27824663
46cellular ketone body metabolic process (GO:0046950)3.26558963
47trophectodermal cell differentiation (GO:0001829)3.26373903
48DNA replication-dependent nucleosome organization (GO:0034723)3.24429659
49DNA replication-dependent nucleosome assembly (GO:0006335)3.24429659
50nuclear pore organization (GO:0006999)3.23189376
51interkinetic nuclear migration (GO:0022027)3.18379468
52apoptotic process involved in morphogenesis (GO:0060561)3.17637526
53epithelial cell-cell adhesion (GO:0090136)3.17110572
54photoreceptor cell maintenance (GO:0045494)3.13465750
55protein K48-linked deubiquitination (GO:0071108)3.12611467
56behavioral response to ethanol (GO:0048149)3.11519504
57sulfation (GO:0051923)3.10957184
58nuclear pore complex assembly (GO:0051292)3.09524981
59embryonic camera-type eye development (GO:0031076)3.05285983
60DNA unwinding involved in DNA replication (GO:0006268)3.05070017
61nodal signaling pathway (GO:0038092)3.04426251
62neural tube formation (GO:0001841)3.04187527
63regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02489537
64embryonic process involved in female pregnancy (GO:0060136)3.02140837
65monoubiquitinated protein deubiquitination (GO:0035520)3.00672497
66protein heterotrimerization (GO:0070208)3.00390554
67amine catabolic process (GO:0009310)3.00324771
68cellular biogenic amine catabolic process (GO:0042402)3.00324771
69serotonin metabolic process (GO:0042428)2.99772142
70snRNA transcription (GO:0009301)2.97625561
71NAD biosynthetic process (GO:0009435)2.96267321
72regulation of establishment of cell polarity (GO:2000114)2.94693905
73ketone body metabolic process (GO:1902224)2.93700371
74neuronal action potential (GO:0019228)2.92490198
75establishment of protein localization to Golgi (GO:0072600)2.91302642
76histone arginine methylation (GO:0034969)2.90514721
77primary amino compound metabolic process (GO:1901160)2.90074280
78negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88313621
79proline biosynthetic process (GO:0006561)2.86410340
80chromatin assembly (GO:0031497)2.85804035
81negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.84672597
82adherens junction assembly (GO:0034333)2.84395819
83peptidyl-arginine omega-N-methylation (GO:0035247)2.84302278
84regulation of integrin activation (GO:0033623)2.82565367
85membrane depolarization during action potential (GO:0086010)2.81402344
86maternal placenta development (GO:0001893)2.81384176
87tachykinin receptor signaling pathway (GO:0007217)2.81229424
88histone H4-K12 acetylation (GO:0043983)2.81190528
89mitotic sister chromatid segregation (GO:0000070)2.79248878
90regulation of establishment or maintenance of cell polarity (GO:0032878)2.77074266
91auditory receptor cell stereocilium organization (GO:0060088)2.77001174
92oxidative demethylation (GO:0070989)2.76060041
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75285949
94regulation of sarcomere organization (GO:0060297)2.74943983
95kidney morphogenesis (GO:0060993)2.74713169
96pericardium development (GO:0060039)2.74577223
97cilium movement (GO:0003341)2.74067241
98mitotic nuclear envelope disassembly (GO:0007077)2.73579897
99establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.72785615
100response to pheromone (GO:0019236)2.72177710
101appendage development (GO:0048736)2.71958351
102limb development (GO:0060173)2.71958351
103benzene-containing compound metabolic process (GO:0042537)2.71610870
104regulation of mesoderm development (GO:2000380)2.69090116
105axoneme assembly (GO:0035082)2.68806130
106negative regulation of Rho protein signal transduction (GO:0035024)2.68569658
107thyroid hormone metabolic process (GO:0042403)2.68396520
108cAMP catabolic process (GO:0006198)2.67569582
109regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.65533986
110regulation of action potential (GO:0098900)2.64883201
111epithelial cilium movement (GO:0003351)2.64039602
112negative regulation of chondrocyte differentiation (GO:0032331)2.63778088
113regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.63748388
114urinary tract smooth muscle contraction (GO:0014848)2.63491027
115wound healing, spreading of epidermal cells (GO:0035313)2.63298989
116endocardial cushion development (GO:0003197)2.62359624
117positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.62184534
118detection of mechanical stimulus involved in sensory perception (GO:0050974)2.61280201
119embryonic placenta development (GO:0001892)2.61105638
120nonmotile primary cilium assembly (GO:0035058)2.60135424
121negative regulation of systemic arterial blood pressure (GO:0003085)2.59435045
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.58829060
123convergent extension (GO:0060026)2.58207735
124cilium morphogenesis (GO:0060271)2.57907511
125drug catabolic process (GO:0042737)2.57317136
126spinal cord motor neuron differentiation (GO:0021522)2.57154358
127regulation of telomere maintenance via telomerase (GO:0032210)2.56802713
128nuclear envelope disassembly (GO:0051081)2.56645290
129membrane disassembly (GO:0030397)2.56645290
130UDP-N-acetylglucosamine metabolic process (GO:0006047)2.56588201
131bone trabecula formation (GO:0060346)2.56549886
132folic acid-containing compound biosynthetic process (GO:0009396)2.56482154
133protein K11-linked deubiquitination (GO:0035871)2.56408474
134sister chromatid segregation (GO:0000819)2.56164504
135cilium organization (GO:0044782)2.56069304
136protein K63-linked deubiquitination (GO:0070536)2.54853463
137regulation of tight junction assembly (GO:2000810)2.54425180
138positive regulation of fatty acid oxidation (GO:0046321)2.54201136
139negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53836878
140regulation of sister chromatid cohesion (GO:0007063)2.53390926
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53103439
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.53103439
143cell migration involved in gastrulation (GO:0042074)2.53078979
144anatomical structure regression (GO:0060033)2.52619969
145inner ear receptor stereocilium organization (GO:0060122)2.51806230
146cell-substrate junction assembly (GO:0007044)2.51447225
147protein localization to chromosome, centromeric region (GO:0071459)2.51116765
148establishment or maintenance of apical/basal cell polarity (GO:0035088)2.50778916
149establishment or maintenance of bipolar cell polarity (GO:0061245)2.50778916
150lung-associated mesenchyme development (GO:0060484)2.50602685
151cellular response to sterol (GO:0036315)2.50434059
152aromatic amino acid family catabolic process (GO:0009074)2.49995565
153cyclic nucleotide catabolic process (GO:0009214)2.49984936
154cornea development in camera-type eye (GO:0061303)2.49686194
155cilium assembly (GO:0042384)2.49435928
156apoptotic process involved in development (GO:1902742)2.48101044
157intestinal epithelial cell development (GO:0060576)2.46312081
158cardiovascular system development (GO:0072358)2.45689671
159intracellular estrogen receptor signaling pathway (GO:0030520)2.45383586
160lipid translocation (GO:0034204)2.45313805
161phospholipid translocation (GO:0045332)2.45313805
162endosome to melanosome transport (GO:0035646)2.45107208
163endosome to pigment granule transport (GO:0043485)2.45107208
164smooth muscle contraction (GO:0006939)2.44916626
165endodermal cell differentiation (GO:0035987)2.44288936
166negative regulation of protein localization to cell surface (GO:2000009)2.44176970
167focal adhesion assembly (GO:0048041)2.43867215
168cell-substrate adherens junction assembly (GO:0007045)2.43867215
169negative regulation of sodium ion transport (GO:0010766)2.43546172
170cellular response to ATP (GO:0071318)2.43059460
171spliceosomal tri-snRNP complex assembly (GO:0000244)2.42965313
172peptidyl-arginine methylation (GO:0018216)2.42434151
173peptidyl-arginine N-methylation (GO:0035246)2.42434151
174negative regulation of cartilage development (GO:0061037)2.42157058
175positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.41129503
176mitotic G1 DNA damage checkpoint (GO:0031571)2.40537053
177positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.39634202
178hemidesmosome assembly (GO:0031581)2.39107524
179membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38750556
180retinal cone cell development (GO:0046549)2.37613165
181positive regulation of CREB transcription factor activity (GO:0032793)2.37587644
182peristalsis (GO:0030432)2.36919329
183regulation of stem cell maintenance (GO:2000036)2.36770756
184transcription from mitochondrial promoter (GO:0006390)2.35959971
185branching involved in mammary gland duct morphogenesis (GO:0060444)2.35424111
186embryonic foregut morphogenesis (GO:0048617)2.35279507
187outer ear morphogenesis (GO:0042473)2.34705593
188DNA duplex unwinding (GO:0032508)2.34473237
189viral transcription (GO:0019083)2.34347605
190lung morphogenesis (GO:0060425)2.33310623
191DNA geometric change (GO:0032392)2.32721796
192mRNA stabilization (GO:0048255)2.31697515
193RNA stabilization (GO:0043489)2.31697515
194labyrinthine layer blood vessel development (GO:0060716)2.31259522
195regulation of G0 to G1 transition (GO:0070316)2.30969857
196translational termination (GO:0006415)2.28245792
197apoptotic cell clearance (GO:0043277)2.27460327
198histone H4-K8 acetylation (GO:0043982)2.26977803
199histone H4-K5 acetylation (GO:0043981)2.26977803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.13684819
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.83959410
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.83959410
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.83959410
5EZH2_22144423_ChIP-Seq_EOC_Human3.72921766
6GBX2_23144817_ChIP-Seq_PC3_Human3.37297515
7ZNF274_21170338_ChIP-Seq_K562_Hela3.18081023
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.17539572
9VDR_22108803_ChIP-Seq_LS180_Human3.12442034
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.11684046
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.96059588
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.95475649
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85930907
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.81459673
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77182973
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.69969578
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69207279
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55667869
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.50434565
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43764109
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41122141
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.39206515
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32704958
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31036012
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25535094
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.24695694
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21334129
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.20566591
29STAT3_1855785_ChIP-Seq_MESCs_Mouse2.14441327
30TCF3_18692474_ChIP-Seq_MESCs_Mouse2.09931878
31IGF1R_20145208_ChIP-Seq_DFB_Human2.09614528
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.05113832
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.00033260
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97514434
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97446119
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95026417
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94396483
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94289140
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92861577
40TAF15_26573619_Chip-Seq_HEK293_Human1.92793042
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.91827949
42P300_19829295_ChIP-Seq_ESCs_Human1.88718989
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87324732
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86747796
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.86451628
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84923782
47* STAT3_23295773_ChIP-Seq_U87_Human1.84550801
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84510707
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81332019
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.80388650
51DROSHA_22980978_ChIP-Seq_HELA_Human1.78493560
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.78392238
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77995868
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77910806
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77203143
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.77023612
57ER_23166858_ChIP-Seq_MCF-7_Human1.76817463
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74173748
59FUS_26573619_Chip-Seq_HEK293_Human1.72974306
60AR_21572438_ChIP-Seq_LNCaP_Human1.72012390
61SMAD4_21799915_ChIP-Seq_A2780_Human1.70920927
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.68698291
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.66908821
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65937418
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63526471
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63526471
67* EWS_26573619_Chip-Seq_HEK293_Human1.62549562
68BCAT_22108803_ChIP-Seq_LS180_Human1.62417015
69* TCF4_23295773_ChIP-Seq_U87_Human1.61989700
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60124173
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60117657
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57937785
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57842440
74TP53_16413492_ChIP-PET_HCT116_Human1.57720369
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.57702440
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55473932
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54412554
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52711390
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52077444
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51897638
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.50984744
82ZNF263_19887448_ChIP-Seq_K562_Human1.49434786
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48348214
84AR_25329375_ChIP-Seq_VCAP_Human1.46777682
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.44506151
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.44398000
87AR_21909140_ChIP-Seq_LNCAP_Human1.43299824
88CBP_20019798_ChIP-Seq_JUKART_Human1.41843402
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41843402
90MYC_22102868_ChIP-Seq_BL_Human1.41574811
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41160245
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40963604
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40718861
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40303623
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40134600
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.40044311
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.39827242
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39504150
99AHR_22903824_ChIP-Seq_MCF-7_Human1.39332727
100XRN2_22483619_ChIP-Seq_HELA_Human1.39047197
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37930962
102RACK7_27058665_Chip-Seq_MCF-7_Human1.36769977
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36421357
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36242422
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34930231
106ATF3_27146783_Chip-Seq_COLON_Human1.34585180
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34121012
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.33914827
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33908765
110SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32536463
111CLOCK_20551151_ChIP-Seq_293T_Human1.32210538
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31957137
113NANOG_18692474_ChIP-Seq_MEFs_Mouse1.31937065
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31916482
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.31299170
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31257180
117TCF4_22108803_ChIP-Seq_LS180_Human1.30657489
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.30392252
119REST_21632747_ChIP-Seq_MESCs_Mouse1.29856694
120CBX2_27304074_Chip-Seq_ESCs_Mouse1.29112229
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29107174
122RUNX2_22187159_ChIP-Seq_PCA_Human1.27655060
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.26222462
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.25848651
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25644570
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25452976
127E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25187152
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.24225326
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23974908
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23621686
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22006566
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21809185
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21747687
134SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21404895
135NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20653192
136* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19059764
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18301805
138MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17927880
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17448069
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16918105
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16591048
142ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15806883
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15650000
144POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15120768
145EED_16625203_ChIP-ChIP_MESCs_Mouse1.14756192
146TP53_22127205_ChIP-Seq_IMR90_Human1.14579272
147RXR_22108803_ChIP-Seq_LS180_Human1.13900211
148IRF1_19129219_ChIP-ChIP_H3396_Human1.13739687
149JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12943324
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12578654
151* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12527647
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12095134
153SOX2_21211035_ChIP-Seq_LN229_Gbm1.11881941
154KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11442022
155PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11314377
156JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10755051
157P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10525244
158FLI1_21867929_ChIP-Seq_TH2_Mouse1.10437639
159KDM2B_26808549_Chip-Seq_REH_Human1.10374454
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10008663
161RNF2_27304074_Chip-Seq_NSC_Mouse1.07162929
162SMAD3_21741376_ChIP-Seq_ESCs_Human1.06344170
163SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06161180
164NFE2_27457419_Chip-Seq_LIVER_Mouse1.05780849
165EZH2_27304074_Chip-Seq_ESCs_Mouse1.05125072
166NANOG_19829295_ChIP-Seq_ESCs_Human1.04952386
167SOX2_19829295_ChIP-Seq_ESCs_Human1.04952386
168SMAD3_21741376_ChIP-Seq_HESCs_Human1.04935415
169TP53_22573176_ChIP-Seq_HFKS_Human1.04465146
170EZH2_27294783_Chip-Seq_NPCs_Mouse1.04379629
171KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04156388
172ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04106381
173* LXR_22292898_ChIP-Seq_THP-1_Human1.03373952
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03103156
175* CJUN_26792858_Chip-Seq_BT549_Human1.02338215
176SMAD4_21741376_ChIP-Seq_HESCs_Human1.01873292
177CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01645000
178KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01562310
179WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00891371
180TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00859850
181KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00580412
182CDX2_22108803_ChIP-Seq_LS180_Human0.99514251
183AR_19668381_ChIP-Seq_PC3_Human0.99445548
184KDM2B_26808549_Chip-Seq_DND41_Human0.99047384
185SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98494125
186CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98249570
187EZH2_27294783_Chip-Seq_ESCs_Mouse0.97722042
188NANOG_16153702_ChIP-ChIP_HESCs_Human0.97481402
189E2F1_21310950_ChIP-Seq_MCF-7_Human0.97298007
190CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97195844
191EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97092589
192NANOG_18555785_Chip-Seq_ESCs_Mouse0.97018017
193* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96702779
194POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95161088
195VDR_21846776_ChIP-Seq_THP-1_Human0.95106216
196TTF2_22483619_ChIP-Seq_HELA_Human0.93122080
197CHD1_26751641_Chip-Seq_LNCaP_Human0.92859539
198TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92026393
199CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90663943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.26012146
2MP0003705_abnormal_hypodermis_morpholog3.98256824
3MP0003646_muscle_fatigue3.88090628
4MP0010030_abnormal_orbit_morphology3.38401231
5MP0008438_abnormal_cutaneous_collagen3.01894446
6MP0003195_calcinosis2.95767910
7MP0010352_gastrointestinal_tract_polyps2.86548619
8MP0004272_abnormal_basement_membrane2.66032731
9MP0004043_abnormal_pH_regulation2.64961277
10MP0005623_abnormal_meninges_morphology2.60239933
11MP0001501_abnormal_sleep_pattern2.51212650
12MP0005551_abnormal_eye_electrophysiolog2.48446378
13MP0003136_yellow_coat_color2.28460172
14MP0001968_abnormal_touch/_nociception2.17653762
15MP0004957_abnormal_blastocyst_morpholog2.17197348
16MP0003283_abnormal_digestive_organ2.15840303
17MP0009046_muscle_twitch2.15654123
18MP0002102_abnormal_ear_morphology2.06876936
19MP0003566_abnormal_cell_adhesion2.05497649
20MP0003941_abnormal_skin_development2.04396518
21MP0005275_abnormal_skin_tensile2.01986788
22MP0002837_dystrophic_cardiac_calcinosis1.98554769
23MP0000427_abnormal_hair_cycle1.97469591
24MP0000537_abnormal_urethra_morphology1.96097824
25MP0002653_abnormal_ependyma_morphology1.95033890
26MP0003119_abnormal_digestive_system1.93085994
27MP0003123_paternal_imprinting1.84473557
28MP0009053_abnormal_anal_canal1.80801335
29MP0002736_abnormal_nociception_after1.79848546
30MP0009745_abnormal_behavioral_response1.79438865
31MP0005076_abnormal_cell_differentiation1.75521097
32MP0004197_abnormal_fetal_growth/weight/1.74804428
33MP0003045_fibrosis1.74688188
34MP0004145_abnormal_muscle_electrophysio1.74464376
35MP0005645_abnormal_hypothalamus_physiol1.69447015
36MP0004130_abnormal_muscle_cell1.67589438
37MP0002084_abnormal_developmental_patter1.66603114
38MP0002085_abnormal_embryonic_tissue1.63746534
39MP0005167_abnormal_blood-brain_barrier1.63658020
40MP0005174_abnormal_tail_pigmentation1.63454794
41MP0004133_heterotaxia1.63418339
42MP0001672_abnormal_embryogenesis/_devel1.61754534
43MP0005380_embryogenesis_phenotype1.61754534
44MP0002938_white_spotting1.60956039
45MP0000383_abnormal_hair_follicle1.60767600
46MP0004142_abnormal_muscle_tone1.57956790
47MP0002086_abnormal_extraembryonic_tissu1.57178102
48MP0010386_abnormal_urinary_bladder1.57134664
49MP0001730_embryonic_growth_arrest1.55365420
50MP0003111_abnormal_nucleus_morphology1.54475483
51MP0003279_aneurysm1.54226835
52MP0008057_abnormal_DNA_replication1.53829645
53MP0005670_abnormal_white_adipose1.53623812
54MP0005646_abnormal_pituitary_gland1.53254295
55MP0005023_abnormal_wound_healing1.52523689
56MP0008872_abnormal_physiological_respon1.52173175
57MP0002876_abnormal_thyroid_physiology1.49796834
58MP0003984_embryonic_growth_retardation1.49248699
59MP0005253_abnormal_eye_physiology1.48670933
60MP0002088_abnormal_embryonic_growth/wei1.48024706
61MP0005377_hearing/vestibular/ear_phenot1.46565244
62MP0003878_abnormal_ear_physiology1.46565244
63MP0003385_abnormal_body_wall1.46163284
64MP0003077_abnormal_cell_cycle1.45739449
65MP0001485_abnormal_pinna_reflex1.45257249
66MP0001849_ear_inflammation1.45023029
67MP0006276_abnormal_autonomic_nervous1.44988796
68MP0004147_increased_porphyrin_level1.44660374
69MP0001697_abnormal_embryo_size1.43603270
70MP0002234_abnormal_pharynx_morphology1.42336607
71MP0002735_abnormal_chemical_nociception1.41939420
72MP0003567_abnormal_fetal_cardiomyocyte1.41714515
73MP0003890_abnormal_embryonic-extraembry1.41444200
74MP0001486_abnormal_startle_reflex1.41226997
75MP0000350_abnormal_cell_proliferation1.40151281
76MP0002272_abnormal_nervous_system1.39957541
77MP0001293_anophthalmia1.38937349
78MP0000762_abnormal_tongue_morphology1.38683348
79MP0005171_absent_coat_pigmentation1.38671001
80MP0003942_abnormal_urinary_system1.37615762
81MP0005257_abnormal_intraocular_pressure1.37248905
82MP0000230_abnormal_systemic_arterial1.36254167
83MP0010234_abnormal_vibrissa_follicle1.35028882
84MP0002249_abnormal_larynx_morphology1.34556687
85MP0000631_abnormal_neuroendocrine_gland1.33963294
86MP0009278_abnormal_bone_marrow1.33924336
87MP0008877_abnormal_DNA_methylation1.32845049
88MP0002572_abnormal_emotion/affect_behav1.32480041
89MP0000733_abnormal_muscle_development1.32446882
90MP0002932_abnormal_joint_morphology1.31510985
91MP0003755_abnormal_palate_morphology1.31346519
92MP0002111_abnormal_tail_morphology1.31142834
93MP0005508_abnormal_skeleton_morphology1.30995613
94MP0000534_abnormal_ureter_morphology1.30540745
95MP0000538_abnormal_urinary_bladder1.28840598
96MP0000428_abnormal_craniofacial_morphol1.28776601
97MP0005503_abnormal_tendon_morphology1.26515950
98MP0003935_abnormal_craniofacial_develop1.25777363
99MP0003937_abnormal_limbs/digits/tail_de1.25597125
100MP0008961_abnormal_basal_metabolism1.25331218
101MP0003122_maternal_imprinting1.24668187
102MP0001984_abnormal_olfaction1.24448493
103MP0008932_abnormal_embryonic_tissue1.24091299
104MP0002282_abnormal_trachea_morphology1.24075224
105MP0001986_abnormal_taste_sensitivity1.23912817
106MP0004264_abnormal_extraembryonic_tissu1.23523608
107MP0004233_abnormal_muscle_weight1.23463025
108MP0010094_abnormal_chromosome_stability1.22726854
109MP0003693_abnormal_embryo_hatching1.22624608
110MP0003115_abnormal_respiratory_system1.21455745
111MP0001970_abnormal_pain_threshold1.20916574
112MP0002697_abnormal_eye_size1.20282132
113MP0002733_abnormal_thermal_nociception1.18527186
114MP0002064_seizures1.18501350
115MP0000049_abnormal_middle_ear1.18471687
116MP0003137_abnormal_impulse_conducting1.16961823
117MP0000516_abnormal_urinary_system1.16450514
118MP0005367_renal/urinary_system_phenotyp1.16450514
119MP0000432_abnormal_head_morphology1.15924493
120MP0001958_emphysema1.15097519
121MP0002080_prenatal_lethality1.14589849
122MP0002928_abnormal_bile_duct1.14162404
123MP0002925_abnormal_cardiovascular_devel1.13466662
124MP0000750_abnormal_muscle_regeneration1.12716287
125MP0010368_abnormal_lymphatic_system1.11807138
126MP0002557_abnormal_social/conspecific_i1.11250807
127MP0002168_other_aberrant_phenotype1.11206482
128MP0003121_genomic_imprinting1.10973121
129MP0006292_abnormal_olfactory_placode1.10768432
130MP0008775_abnormal_heart_ventricle1.10154574
131MP0005386_behavior/neurological_phenoty1.09117851
132MP0004924_abnormal_behavior1.09117851
133MP0001915_intracranial_hemorrhage1.08690029
134MP0002067_abnormal_sensory_capabilities1.07206615
135MP0004885_abnormal_endolymph1.07120809
136MP0004185_abnormal_adipocyte_glucose1.06811560
137MP0006072_abnormal_retinal_apoptosis1.05237593
138MP0002092_abnormal_eye_morphology1.05048761
139MP0002638_abnormal_pupillary_reflex1.04839728
140MP0003635_abnormal_synaptic_transmissio1.02407309
141MP0004215_abnormal_myocardial_fiber1.00089464
142MP0001664_abnormal_digestion0.99278485
143MP0009250_abnormal_appendicular_skeleto0.98868466
144MP0002796_impaired_skin_barrier0.98094030
145MP0002063_abnormal_learning/memory/cond0.97885203
146MP0003950_abnormal_plasma_membrane0.97587244
147MP0003091_abnormal_cell_migration0.97222158
148MP0004085_abnormal_heartbeat0.96815950
149MP0008007_abnormal_cellular_replicative0.96594351
150MP0002116_abnormal_craniofacial_bone0.95654182
151MP0002138_abnormal_hepatobiliary_system0.95216692
152MP0002060_abnormal_skin_morphology0.93324330
153MP0010630_abnormal_cardiac_muscle0.92634146
154MP0005195_abnormal_posterior_eye0.91348177
155MP0003252_abnormal_bile_duct0.91302225
156MP0002114_abnormal_axial_skeleton0.89741485
157MP0004084_abnormal_cardiac_muscle0.89545297
158MP0004858_abnormal_nervous_system0.88741489
159MP0000026_abnormal_inner_ear0.88071929
160MP0003879_abnormal_hair_cell0.87868662
161MP0005410_abnormal_fertilization0.87145505
162MP0002877_abnormal_melanocyte_morpholog0.87040674
163MP0002233_abnormal_nose_morphology0.87040172
164MP0000767_abnormal_smooth_muscle0.86884416
165MP0010307_abnormal_tumor_latency0.85993447
166MP0005501_abnormal_skin_physiology0.85488373
167MP0003453_abnormal_keratinocyte_physiol0.85285703
168MP0001614_abnormal_blood_vessel0.84839939
169MP0006054_spinal_hemorrhage0.84426054
170MP0005595_abnormal_vascular_smooth0.82950095
171MP0003828_pulmonary_edema0.82946750
172MP0002752_abnormal_somatic_nervous0.81787313
173MP0003718_maternal_effect0.81352240
174MP0002160_abnormal_reproductive_system0.81018846
175MP0000266_abnormal_heart_morphology0.80702795
176MP0002332_abnormal_exercise_endurance0.79886248
177MP0002184_abnormal_innervation0.79754138
178MP0009703_decreased_birth_body0.79533156
179MP0000470_abnormal_stomach_morphology0.79046245
180MP0005620_abnormal_muscle_contractility0.78580819
181MP0005448_abnormal_energy_balance0.77340816
182MP0009384_cardiac_valve_regurgitation0.77203457
183MP0001963_abnormal_hearing_physiology0.75080360
184MP0003880_abnormal_central_pattern0.73755006
185MP0005395_other_phenotype0.73344823
186MP0000778_abnormal_nervous_system0.73158668
187MP0001756_abnormal_urination0.73137792
188MP0005085_abnormal_gallbladder_physiolo0.72834658

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)5.03503788
2Genetic anticipation (HP:0003743)4.81865449
3Protrusio acetabuli (HP:0003179)4.51939496
4Hyperventilation (HP:0002883)4.31199355
5Pancreatic fibrosis (HP:0100732)4.29122227
6True hermaphroditism (HP:0010459)3.98174485
7Premature rupture of membranes (HP:0001788)3.91647650
8Molar tooth sign on MRI (HP:0002419)3.90919828
9Abnormality of midbrain morphology (HP:0002418)3.90919828
10Congenital stationary night blindness (HP:0007642)3.89755662
11Gaze-evoked nystagmus (HP:0000640)3.78573160
12Progressive cerebellar ataxia (HP:0002073)3.77551927
13Nephronophthisis (HP:0000090)3.60238836
14Shallow orbits (HP:0000586)3.55252423
15Attenuation of retinal blood vessels (HP:0007843)3.51935714
16Cerebral aneurysm (HP:0004944)3.49184364
17Cystic liver disease (HP:0006706)3.43690244
18Abnormality of the renal cortex (HP:0011035)3.42956188
19Protruding tongue (HP:0010808)3.39371139
20Abnormality of the renal medulla (HP:0100957)3.32958236
21Clumsiness (HP:0002312)3.32815639
22Chronic hepatic failure (HP:0100626)3.30557742
23Type II lissencephaly (HP:0007260)3.13970462
24Tubular atrophy (HP:0000092)3.12256185
25Ulnar bowing (HP:0003031)3.11689764
26Selective tooth agenesis (HP:0001592)3.10633932
27Rib fusion (HP:0000902)3.10323215
28Ependymoma (HP:0002888)2.98501457
29Short humerus (HP:0005792)2.98472031
30Ankle contracture (HP:0006466)2.97067804
31Aplasia/hypoplasia of the humerus (HP:0006507)2.96443226
32Medial flaring of the eyebrow (HP:0010747)2.90702395
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.83176538
34Keratoconus (HP:0000563)2.81199771
35Increased corneal curvature (HP:0100692)2.81199771
36Inability to walk (HP:0002540)2.72960015
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.68473309
38Missing ribs (HP:0000921)2.67382989
39Abnormality of alanine metabolism (HP:0010916)2.63710885
40Hyperalaninemia (HP:0003348)2.63710885
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63710885
42Polydipsia (HP:0001959)2.63133872
43Abnormal drinking behavior (HP:0030082)2.63133872
44Large for gestational age (HP:0001520)2.61356779
45Cerebellar dysplasia (HP:0007033)2.61269732
46Decreased circulating renin level (HP:0003351)2.60413950
47Genu recurvatum (HP:0002816)2.60201101
48Abnormality of the astrocytes (HP:0100707)2.58812219
49Astrocytoma (HP:0009592)2.58812219
50Congenital sensorineural hearing impairment (HP:0008527)2.56623584
51Renal duplication (HP:0000075)2.55118938
52Increased connective tissue (HP:0009025)2.53582850
53Fused cervical vertebrae (HP:0002949)2.50116050
54Patellar aplasia (HP:0006443)2.48040647
55Febrile seizures (HP:0002373)2.47761704
56Bony spicule pigmentary retinopathy (HP:0007737)2.47598065
57Abolished electroretinogram (ERG) (HP:0000550)2.44006258
58Shawl scrotum (HP:0000049)2.42586524
59Trismus (HP:0000211)2.42092140
60Congenital hepatic fibrosis (HP:0002612)2.41607928
61Sclerocornea (HP:0000647)2.39628671
62Fair hair (HP:0002286)2.39211723
63Gait imbalance (HP:0002141)2.38900817
64Broad-based gait (HP:0002136)2.38715707
65Hypoplastic ischia (HP:0003175)2.34040968
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.33818404
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.33375247
68Atrophic scars (HP:0001075)2.32639689
69Congenital primary aphakia (HP:0007707)2.31692337
70Aplasia/Hypoplasia of the patella (HP:0006498)2.31132178
71Bladder diverticulum (HP:0000015)2.30052603
72Multiple enchondromatosis (HP:0005701)2.29162203
73Chorioretinal atrophy (HP:0000533)2.28862358
74Furrowed tongue (HP:0000221)2.24452307
75Short 4th metacarpal (HP:0010044)2.23720379
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23720379
77Absent speech (HP:0001344)2.23076661
78Progressive inability to walk (HP:0002505)2.20088155
79Birth length less than 3rd percentile (HP:0003561)2.19893053
80Bulbous nose (HP:0000414)2.15392453
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14723211
82Turricephaly (HP:0000262)2.13842615
83Anencephaly (HP:0002323)2.13718159
84Rectovaginal fistula (HP:0000143)2.13093625
85Rectal fistula (HP:0100590)2.13093625
86Bowed forearm bones (HP:0003956)2.12577938
87Bowing of the arm (HP:0006488)2.12577938
88Lissencephaly (HP:0001339)2.11925413
89Genital tract atresia (HP:0001827)2.11274119
90Vertebral fusion (HP:0002948)2.11087923
91Broad thumb (HP:0011304)2.10733148
92Abnormality of the ischium (HP:0003174)2.10309334
93Pendular nystagmus (HP:0012043)2.10211105
94Hypoplasia of the pons (HP:0012110)2.09091225
95Abnormality of the renal collecting system (HP:0004742)2.08758098
96Vaginal atresia (HP:0000148)2.08429492
97Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07873502
98Vertebral hypoplasia (HP:0008417)2.07873502
99Polyuria (HP:0000103)2.06549272
100Broad metatarsal (HP:0001783)2.06238780
101Blue sclerae (HP:0000592)2.05686009
102Nephrogenic diabetes insipidus (HP:0009806)2.05612916
103Metaphyseal cupping (HP:0003021)2.05341064
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.03833825
105Absent/shortened dynein arms (HP:0200106)2.03833825
106Abnormality of the pons (HP:0007361)2.03828217
107Coronal craniosynostosis (HP:0004440)2.03404902
108Distal upper limb amyotrophy (HP:0007149)2.03263365
109Upper limb amyotrophy (HP:0009129)2.03263365
110Wrist flexion contracture (HP:0001239)2.01392639
111Cervical subluxation (HP:0003308)2.00922558
112Mitral valve prolapse (HP:0001634)2.00865524
113Abnormality of dentin (HP:0010299)1.99881376
114Difficulty climbing stairs (HP:0003551)1.99207616
115Vaginal fistula (HP:0004320)1.98616173
116Poor coordination (HP:0002370)1.98055138
117Duplicated collecting system (HP:0000081)1.97917730
118Absent radius (HP:0003974)1.97162290
119Neoplasm of striated muscle (HP:0009728)1.97018373
120Decreased central vision (HP:0007663)1.95566405
121Stomach cancer (HP:0012126)1.95294187
122Renal cortical cysts (HP:0000803)1.94981032
123Rhabdomyosarcoma (HP:0002859)1.94887252
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.94249947
125Postaxial foot polydactyly (HP:0001830)1.94109196
126Abnormal ciliary motility (HP:0012262)1.93639664
127Hand muscle atrophy (HP:0009130)1.92729330
128Short foot (HP:0001773)1.92540058
129Widely spaced teeth (HP:0000687)1.92458426
130Abnormality of the 4th metacarpal (HP:0010012)1.91831070
131Aortic dissection (HP:0002647)1.90733805
132Preaxial foot polydactyly (HP:0001841)1.89769809
133Short 1st metacarpal (HP:0010034)1.89744242
134Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89744242
135Esophageal atresia (HP:0002032)1.88403498
136Congenital, generalized hypertrichosis (HP:0004540)1.87987703
137Soft skin (HP:0000977)1.87986190
138Colon cancer (HP:0003003)1.87651498
139Spinal rigidity (HP:0003306)1.85737777
140Focal seizures (HP:0007359)1.85716665
141Generalized hypopigmentation of hair (HP:0011358)1.85577747
142Abnormality of the lower motor neuron (HP:0002366)1.85549582
143Dialeptic seizures (HP:0011146)1.85381977
144Neoplasm of the oral cavity (HP:0100649)1.84996151
145Glioma (HP:0009733)1.84630388
146Neonatal short-limb short stature (HP:0008921)1.84059734
147Broad toe (HP:0001837)1.83913863
148Short phalanx of the thumb (HP:0009660)1.83829366
149Abnormal rod and cone electroretinograms (HP:0008323)1.83691272
150Mildly elevated creatine phosphokinase (HP:0008180)1.83142164
151Aneurysm (HP:0002617)1.82664243
152Aplasia involving forearm bones (HP:0009822)1.82421934
153Absent forearm bone (HP:0003953)1.82421934
154Small hand (HP:0200055)1.82310547
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82031301
156Peritonitis (HP:0002586)1.80140996
157Abnormality of the calcaneus (HP:0008364)1.80045719
158Atresia of the external auditory canal (HP:0000413)1.79900749
159Abnormality of the fetal cardiovascular system (HP:0010948)1.79699219
160Abnormal umbilical cord blood vessels (HP:0011403)1.79699219
161Single umbilical artery (HP:0001195)1.79699219
162Bowel diverticulosis (HP:0005222)1.78840452
163Fragile skin (HP:0001030)1.78618438
164Concave nail (HP:0001598)1.77819280
165Camptodactyly of toe (HP:0001836)1.77369529
166Intestinal fistula (HP:0100819)1.77035635
167Vertebral clefting (HP:0008428)1.76807839
168Short 5th finger (HP:0009237)1.76278229
169Deviation of the thumb (HP:0009603)1.76112899
170Hemiparesis (HP:0001269)1.75861902
171Bile duct proliferation (HP:0001408)1.75618983
172Abnormal biliary tract physiology (HP:0012439)1.75618983
173Mesomelia (HP:0003027)1.74845300
174Achilles tendon contracture (HP:0001771)1.74757819
175Lymphangioma (HP:0100764)1.74206988
176Breast hypoplasia (HP:0003187)1.73250155
177Supernumerary ribs (HP:0005815)1.72773131
178Radial bowing (HP:0002986)1.72623605
179Adenoma sebaceum (HP:0009720)1.72577630
180Angiofibromas (HP:0010615)1.72577630
181Abnormality of the 1st metacarpal (HP:0010009)1.72229327
182Abnormality of the labia minora (HP:0012880)1.71743758
183Highly arched eyebrow (HP:0002553)1.71167194
184Amelogenesis imperfecta (HP:0000705)1.70450406
185Male pseudohermaphroditism (HP:0000037)1.70429478
186Deviation of the hallux (HP:0010051)1.70384403
187Bilateral microphthalmos (HP:0007633)1.69887758
188Broad phalanges of the hand (HP:0009768)1.69332458
189Fibroma (HP:0010614)1.69004692
190Central scotoma (HP:0000603)1.67833541
191Carpal synostosis (HP:0009702)1.67480948
192Hip contracture (HP:0003273)1.66820875
193Preaxial hand polydactyly (HP:0001177)1.65647899
194Abnormality of the pubic bones (HP:0003172)1.64197318
195Tubulointerstitial fibrosis (HP:0005576)1.63655875
196Tubulointerstitial abnormality (HP:0001969)1.62988080
197Severe muscular hypotonia (HP:0006829)1.61485645
198Impaired smooth pursuit (HP:0007772)1.60475805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.85665177
2CDK124.00345235
3ACVR1B3.70846775
4BMPR1B3.48225578
5EPHA23.19032172
6LATS22.92581219
7DDR22.92372895
8ADRBK22.89747778
9ICK2.71509432
10TRIB32.58239134
11PKN22.42661124
12LATS12.40819239
13PDGFRA2.37458731
14ZAK2.22917646
15PAK42.11214636
16GRK12.07999591
17TTN2.07627762
18INSRR2.06682749
19WNK42.02539061
20MAP3K102.02016236
21TYRO31.95470943
22PINK11.94345611
23TAOK31.86441300
24BMX1.81466837
25ERN11.79357021
26TTK1.75264985
27CDK71.71041652
28RPS6KB21.68803140
29EPHB21.65664784
30WNK31.63308256
31CASK1.59132682
32DAPK21.56449068
33ADRBK11.56231148
34RIPK11.54106190
35STK38L1.53482548
36NEK11.51710671
37MAP4K21.49744055
38NUAK11.49728804
39NEK21.49605003
40STK391.47183800
41CDC71.44890706
42MAPK131.40083735
43MTOR1.39959000
44BUB11.39652472
45MKNK21.38314755
46WEE11.38191702
47NTRK31.34456356
48MET1.33110057
49OXSR11.31739315
50EEF2K1.30923141
51PTK21.29853203
52PIK3CG1.27203594
53PAK21.22324284
54MAP3K41.19129123
55PTK61.13994825
56PTK2B1.13805613
57PLK11.12708779
58STK101.08514627
59MAP3K81.07332141
60CDK61.05989304
61MATK1.01500873
62STK31.01102565
63CHEK21.00662633
64MAPKAPK30.97522527
65CAMK1D0.94472660
66MAP3K70.94027750
67TGFBR20.93341770
68LRRK20.93147210
69CDK40.91795437
70FER0.91303816
71ALK0.91237842
72CAMK10.90635012
73FGFR10.90587020
74TRPM70.90168496
75PIK3CA0.90128104
76AKT30.88418592
77MAP3K110.88257606
78TGFBR10.87080652
79CAMK1G0.85678302
80MUSK0.84387288
81NME20.84222860
82SCYL20.82752931
83PRKAA20.82511189
84TNIK0.82331999
85PAK30.81571616
86AURKB0.81180683
87FGFR20.80923816
88ILK0.77844242
89MYLK0.77574962
90PRKCE0.77497725
91PRKD30.77295311
92TXK0.77287169
93PAK10.73930053
94PRKCI0.73807612
95DYRK30.73708676
96MOS0.73083047
97AURKA0.72575082
98CHEK10.71573672
99MAP3K30.71521459
100PRKCG0.70993592
101OBSCN0.70403951
102TNK20.69784631
103NLK0.69089850
104DYRK1B0.68755267
105AKT20.68717058
106FLT30.68228833
107MARK10.67315368
108RPS6KA40.66555808
109SGK20.66014011
110MAPK150.66013786
111TEC0.64353611
112SIK20.63537715
113RPS6KA60.61967762
114WNK10.61106913
115KIT0.61033982
116GSK3A0.59938187
117PRKD20.59344006
118PRKAA10.58565856
119TIE10.58227440
120CDK20.57958128
121CHUK0.57458650
122PASK0.57024573
123CAMK40.56982304
124MAP2K60.56703331
125TESK10.56311747
126MAP3K60.55731929
127TAOK20.55548676
128CAMKK20.54565644
129CAMK2A0.54454265
130FGR0.54450053
131CDC42BPA0.51724801
132PDGFRB0.51069199
133MAP2K20.50723561
134MAP2K30.50516745
135DMPK0.50453240
136STK110.49589675
137TESK20.48877510
138RPS6KC10.47500787
139RPS6KL10.47500787
140PIM10.47363770
141MAP2K10.47123537
142NTRK20.46882535
143DAPK30.46741219
144PRKG20.46586288
145SIK10.46228165
146PNCK0.46141539
147GRK60.45199533
148TLK10.44942702
149ATR0.44628175
150ERBB20.44471580
151SGK2230.43665091
152SGK4940.43665091
153PKN10.43473999
154CSNK1E0.41606528
155CSK0.41344425
156RPS6KA50.40368762
157INSR0.40068299
158ATM0.40040492
159TSSK60.39344467
160BRD40.38643108
161PHKG20.38604711
162PHKG10.38604711
163KDR0.38604685
164MAPKAPK50.38284478
165CSNK1A1L0.36129463
166MAPK10.35883111
167MELK0.34868257
168MAP2K70.34776486
169ITK0.34255970
170PRKACA0.34163886
171STK380.34119501
172CSNK1D0.33794134
173PRKCH0.33701200
174IRAK10.33526386
175IKBKB0.33079694
176GRK70.31268462
177CSNK1A10.30958179
178MKNK10.29273706
179NME10.28931958
180EPHA40.28249098
181PRKG10.26845794
182BRSK20.26844777
183PRKCQ0.25777588
184PRKCZ0.24869026

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.73026126
2Mismatch repair_Homo sapiens_hsa034302.67283983
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61824680
4Basal cell carcinoma_Homo sapiens_hsa052172.61398394
5* Hippo signaling pathway_Homo sapiens_hsa043902.60079706
6RNA transport_Homo sapiens_hsa030132.58379232
7Nitrogen metabolism_Homo sapiens_hsa009102.49671922
8ABC transporters_Homo sapiens_hsa020102.42314514
9DNA replication_Homo sapiens_hsa030302.41543908
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40521017
11Nicotine addiction_Homo sapiens_hsa050332.39722265
12Linoleic acid metabolism_Homo sapiens_hsa005912.36649375
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35740514
14ECM-receptor interaction_Homo sapiens_hsa045122.29645261
15Hedgehog signaling pathway_Homo sapiens_hsa043402.28165989
16Adherens junction_Homo sapiens_hsa045202.23715538
17Tryptophan metabolism_Homo sapiens_hsa003802.23252638
18Spliceosome_Homo sapiens_hsa030402.21802645
19Butanoate metabolism_Homo sapiens_hsa006502.20409993
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14671723
21Bladder cancer_Homo sapiens_hsa052192.11196028
22Ribosome_Homo sapiens_hsa030102.07686879
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05572462
24Taste transduction_Homo sapiens_hsa047422.04628249
25One carbon pool by folate_Homo sapiens_hsa006702.00768960
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99252183
27TGF-beta signaling pathway_Homo sapiens_hsa043501.95479811
28Cell cycle_Homo sapiens_hsa041101.92917025
29mRNA surveillance pathway_Homo sapiens_hsa030151.92421514
30Focal adhesion_Homo sapiens_hsa045101.88831244
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84574109
32Small cell lung cancer_Homo sapiens_hsa052221.83838408
33Morphine addiction_Homo sapiens_hsa050321.77137130
34Tight junction_Homo sapiens_hsa045301.76335230
35Base excision repair_Homo sapiens_hsa034101.75701123
36p53 signaling pathway_Homo sapiens_hsa041151.74371109
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73922981
38Proteoglycans in cancer_Homo sapiens_hsa052051.72202758
39MicroRNAs in cancer_Homo sapiens_hsa052061.67964240
40Ether lipid metabolism_Homo sapiens_hsa005651.58836701
41Notch signaling pathway_Homo sapiens_hsa043301.57471325
42Circadian entrainment_Homo sapiens_hsa047131.52588542
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.51970417
44Olfactory transduction_Homo sapiens_hsa047401.51389670
45Nucleotide excision repair_Homo sapiens_hsa034201.50783799
46mTOR signaling pathway_Homo sapiens_hsa041501.47876025
47Ovarian steroidogenesis_Homo sapiens_hsa049131.44835313
48Glutamatergic synapse_Homo sapiens_hsa047241.44403531
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.44301644
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.42761784
51Calcium signaling pathway_Homo sapiens_hsa040201.42155558
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40921533
53Glycerolipid metabolism_Homo sapiens_hsa005611.40336984
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36806844
55Histidine metabolism_Homo sapiens_hsa003401.36528571
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33949325
57Serotonergic synapse_Homo sapiens_hsa047261.33768220
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32979928
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32204806
60Salivary secretion_Homo sapiens_hsa049701.32102737
61Insulin secretion_Homo sapiens_hsa049111.29998120
62Thyroid cancer_Homo sapiens_hsa052161.28943047
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28240072
64Central carbon metabolism in cancer_Homo sapiens_hsa052301.27261886
65GABAergic synapse_Homo sapiens_hsa047271.26439676
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24325132
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24301973
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.23885784
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23585490
70Dorso-ventral axis formation_Homo sapiens_hsa043201.20029159
71Wnt signaling pathway_Homo sapiens_hsa043101.18651886
72Pathways in cancer_Homo sapiens_hsa052001.17290770
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15545152
74Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13382831
75Chemical carcinogenesis_Homo sapiens_hsa052041.08463525
76PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06787781
77Chronic myeloid leukemia_Homo sapiens_hsa052201.06673405
78Retinol metabolism_Homo sapiens_hsa008301.04841233
79Amoebiasis_Homo sapiens_hsa051461.04698608
80Biosynthesis of amino acids_Homo sapiens_hsa012301.03775572
81HTLV-I infection_Homo sapiens_hsa051661.02944382
82beta-Alanine metabolism_Homo sapiens_hsa004101.02482595
83Caffeine metabolism_Homo sapiens_hsa002321.02473182
84Protein digestion and absorption_Homo sapiens_hsa049741.01763198
85Melanoma_Homo sapiens_hsa052180.98981287
86Homologous recombination_Homo sapiens_hsa034400.97902402
87Viral carcinogenesis_Homo sapiens_hsa052030.96952659
88RNA polymerase_Homo sapiens_hsa030200.95908050
89Colorectal cancer_Homo sapiens_hsa052100.93421559
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92784643
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91597313
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89266626
93Oxytocin signaling pathway_Homo sapiens_hsa049210.88748811
94Arachidonic acid metabolism_Homo sapiens_hsa005900.88382768
95Fanconi anemia pathway_Homo sapiens_hsa034600.87381743
96Gastric acid secretion_Homo sapiens_hsa049710.87002290
97Lysine degradation_Homo sapiens_hsa003100.86326541
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85999031
99Endometrial cancer_Homo sapiens_hsa052130.84790160
100Long-term depression_Homo sapiens_hsa047300.84355148
101Fructose and mannose metabolism_Homo sapiens_hsa000510.83595720
102Cholinergic synapse_Homo sapiens_hsa047250.83490346
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83102230
104Rap1 signaling pathway_Homo sapiens_hsa040150.82246037
105Sulfur relay system_Homo sapiens_hsa041220.82183838
106cAMP signaling pathway_Homo sapiens_hsa040240.80632339
107Prostate cancer_Homo sapiens_hsa052150.80126551
108Dilated cardiomyopathy_Homo sapiens_hsa054140.79479412
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79112507
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77899364
111Oocyte meiosis_Homo sapiens_hsa041140.77740682
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76029389
113Systemic lupus erythematosus_Homo sapiens_hsa053220.75842094
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75634014
115HIF-1 signaling pathway_Homo sapiens_hsa040660.74036555
116Renin secretion_Homo sapiens_hsa049240.72412580
117RNA degradation_Homo sapiens_hsa030180.71786966
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71471935
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69591782
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.69331382
121Galactose metabolism_Homo sapiens_hsa000520.68657052
122VEGF signaling pathway_Homo sapiens_hsa043700.67523241
123Viral myocarditis_Homo sapiens_hsa054160.67429382
124Circadian rhythm_Homo sapiens_hsa047100.67124486
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66420385
126Dopaminergic synapse_Homo sapiens_hsa047280.65750385
127Arginine and proline metabolism_Homo sapiens_hsa003300.62588404
128AMPK signaling pathway_Homo sapiens_hsa041520.61848900
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61694692
130Melanogenesis_Homo sapiens_hsa049160.61396452
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.60766778
132Selenocompound metabolism_Homo sapiens_hsa004500.59683495
133Peroxisome_Homo sapiens_hsa041460.59055481
134Type II diabetes mellitus_Homo sapiens_hsa049300.59046117
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58974615
136Cocaine addiction_Homo sapiens_hsa050300.57726027
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.57113365
138Pancreatic secretion_Homo sapiens_hsa049720.55331248
139Renal cell carcinoma_Homo sapiens_hsa052110.54753317
140Carbon metabolism_Homo sapiens_hsa012000.53258025
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52842117
142Basal transcription factors_Homo sapiens_hsa030220.52398071
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51832682
144Propanoate metabolism_Homo sapiens_hsa006400.51714198
145Sphingolipid metabolism_Homo sapiens_hsa006000.51464779
146Bile secretion_Homo sapiens_hsa049760.51027535
147Fatty acid biosynthesis_Homo sapiens_hsa000610.50771866
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50746188
149Cyanoamino acid metabolism_Homo sapiens_hsa004600.50562934
150Vitamin digestion and absorption_Homo sapiens_hsa049770.49793212
151Pyrimidine metabolism_Homo sapiens_hsa002400.49172378
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48242922
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47930810
154Shigellosis_Homo sapiens_hsa051310.47860948
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47693568
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46803799
157Acute myeloid leukemia_Homo sapiens_hsa052210.46422989
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45982472
159Glutathione metabolism_Homo sapiens_hsa004800.45976833
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45504667
161Fat digestion and absorption_Homo sapiens_hsa049750.44867258
162Pancreatic cancer_Homo sapiens_hsa052120.44701277
163Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42063353
164Proteasome_Homo sapiens_hsa030500.40314366
165Axon guidance_Homo sapiens_hsa043600.40134924
166Glioma_Homo sapiens_hsa052140.39664820
167Mineral absorption_Homo sapiens_hsa049780.39318768
168Non-small cell lung cancer_Homo sapiens_hsa052230.38567635
169Regulation of autophagy_Homo sapiens_hsa041400.38317511
170MAPK signaling pathway_Homo sapiens_hsa040100.38308180
171Ras signaling pathway_Homo sapiens_hsa040140.38099060
172Apoptosis_Homo sapiens_hsa042100.37924316
173Amphetamine addiction_Homo sapiens_hsa050310.37539457
174Epstein-Barr virus infection_Homo sapiens_hsa051690.36853212
175Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36821694
176Cardiac muscle contraction_Homo sapiens_hsa042600.36519611
177Prion diseases_Homo sapiens_hsa050200.35323299
178Purine metabolism_Homo sapiens_hsa002300.35171826
179Gap junction_Homo sapiens_hsa045400.34082200
180Insulin signaling pathway_Homo sapiens_hsa049100.33301259

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